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https://www.readbyqxmd.com/read/28813914/data-sample-size-needed-for-analysis-of-kinematic-and-muscle-synergies-in-healthy-and-stroke-populations
#1
Navid Lambert-Shirzad, H F Machiel Van der Loos
Multiple studies have suggested the central nervous system (CNS) generates motions by using modular control of muscles and joints (synergies). However, the synergies reported by these studies are task dependent and might not reflect the true control strategies adopted by the CNS. Studying exploratory motions (EMs) can reveal biomechanical constraints and motor control strategies in healthy and clinical populations. The first logical step to consider EMs in study of motor synergies is to determine how much data is required to reliably and fully profile the motion patterns of an individual...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813883/development-of-a-series-wrapping-cam-mechanism-for-energy-transfer-in-wearable-arm-support-applications
#2
Jeremiah S Schroeder, Joel C Perry
An estimated 17 million individuals suffer a stroke each year with over 5 million resulting in permanent disability. For many of these, the provision of gravity support to the impaired upper limb can provide significant and immediate improvement in arm mobility. This added mobility has the potential to improve arm function and user independence overall, but, so far, wearable arm supports have found only limited uptake by end-users. The reasons are unclear, but it is hypothesized that device uptake is strongly affected by aspects of arm support implementation such as added weight and volume and the effectiveness of the support provided...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813799/toward-emg-controlled-force-field-generation-for-training-and-rehabilitation-from-movement-data-to-muscle-geometry
#3
Nicola Lotti, Vittorio Sanguinati
EMG signals are often used to control prostheses or assistive devices, but have been rarely used in rehabilitation. We propose a novel approach to personalised rehabilitation, based on EMG-driven force field adaptation. As a step toward this direction, here we show how EMG activity and movement data during a robot-assisted motor task can be used to estimate muscle geometry. We compare three different models of muscle geometry, characterised by (i) constant moment arms (CM); (ii) a normative model, based on polynomial functions of joint angles with fixed coefficients (normative polynomial, NP); and (iii) a person-adaptive model, in which the same polynomial model is fitted to individual subjects data (fitted polynomial, FP)...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813696/effects-of-standardized-home-training-in-patients-with-cognitive-impairment-following-geriatric-rehabilitation-a-randomized-controlled-pilot-study
#4
Klaus Hauer, Phoebe Ullrich, Ilona Dutzi, Rainer Beurskens, Sylvia Kern, Jürgen Bauer, Michael Schwenk
BACKGROUND: Post-ward geriatric rehabilitation programs have hardly been developed and validated, which leaves a substantial gap in rehabilitative care in older adults and hinders full exploitation of maintained, but often unrecognized rehabilitation potentials. Geriatric rehabilitation patients with cognitive impairment represent a highly vulnerable population which is often affected by a lack of an ongoing support at the intersection between ward-based and post-ward rehabilitation. OBJECTIVE: To determine the effect of a standardized home-based training program in geriatric patients with cognitive impairment following ward-based rehabilitation...
August 17, 2017: Gerontology
https://www.readbyqxmd.com/read/28813621/improvement-of-an-in-vitro-model-to-assess-delivered-dose-and-particle-size-for-a-vibrating-mesh-nebulizer-during-mechanical-ventilation
#5
Nani Kadrichu, Derek Daniher
BACKGROUND: In an in vitro model of mechanical ventilation with gravity-dependent filter position we observed artificially high delivered doses resulting from liquid droplet collection and precipitation of aerosolized drug. We sequentially modified the model to obtain accurate reproducible measurements of delivered dose and particle size at endotracheal tube exit. METHODS: Stepwise changes in the model included (1) altering the endotracheal tube position to a gravity-independent position, (2) adding fluid traps, (3) humidifying air near the test lung, and (4) simplifying test lung and filters...
August 16, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28813603/modeling-optical-spectra-of-large-organic-systems-using-real-time-propagation-of-semiempirical-effective-hamiltonians
#6
Soumen Ghosh, Amity Andersen, Laura Gagliardi, Christopher J Cramer, Niranjan Govind
We present an implementation of a time-dependent semiempirical method (INDO/S) in NWChem using real-time (RT) propagation to address, in principle, the entire spectrum of valence electronic excitations. Adopting this model, we study the UV-visible spectra of medium-sized systems like P3B2, f-coronene, and in addition much larger systems like ubiquitin in the gas phase and the betanin chromophore in the presence of two explicit solvents (water and methanol). RT-INDO/S provides qualitatively and indeed often quantitatively accurate results when compared with RT- TDDFT or experimental spectra...
August 16, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28813440/invasive-australian-acacia-seed-banks-size-and-relationship-with-stem-diameter-in-the-presence-of-gall-forming-biological-control-agents
#7
Matthys Strydom, Ruan Veldtman, Mzabalazo Z Ngwenya, Karen J Esler
Australian Acacia are invasive in many parts of the world. Despite significant mechanical and biological efforts to control their invasion and spread, soil-stored seed banks prevent their effective and sustained removal. In response South Africa has had a strong focus on employing seed reducing biological control agents to deal with Australian Acacia invasion, a programme that is considered as being successful. To provide a predictive understanding for their management, seed banks of four invasive Australian acacia species (Acacia longifolia, A...
2017: PloS One
https://www.readbyqxmd.com/read/28813235/temporary-hearing-threshold-shift-in-healthy-volunteers-with-hearing-protection-caused-by-acoustic-noise-exposure-during-3-t-multisequence-mr-neuroimaging
#8
Chao Jin, Huan Li, Xianjun Li, Miaomiao Wang, Congcong Liu, Jianxin Guo, Jian Yang
Purpose To determine whether a single 51-minute exposure to acoustic noise during 3-T multisequence magnetic resonance (MR) neuroimaging could affect the hearing threshold of healthy adults with earplugs and sponge mats as hearing protection. Materials and Methods With earplugs and motion-refraining sponge mats as hearing protection, 26 healthy young adults underwent 3-T MR neuroimaging imaging that included T1-weighted three-dimensional gradient-echo sequence, T2-weighted fast spin-echo sequence, diffusion-tensor imaging, diffusion-kurtosis imaging, T2*-weighted three-dimensional multiecho gradient-echo sequence, and blood oxygen level-dependent imaging...
August 16, 2017: Radiology
https://www.readbyqxmd.com/read/28813182/impact-of-selection-bias-on-treatment-effect-size-estimates-in-randomized-trials-of-oral-health-interventions-a-meta-epidemiological-study
#9
H Saltaji, S Armijo-Olivo, G G Cummings, M Amin, B R da Costa, C Flores-Mir
Emerging evidence suggests that design flaws of randomized controlled trials can result in over- or underestimation of the treatment effect size (ES). The objective of this study was to examine associations between treatment ES estimates and adequacy of sequence generation, allocation concealment, and baseline comparability among a sample of oral health randomized controlled trials. For our analysis, we selected all meta-analyses that included a minimum of 5 oral health randomized controlled trials and used continuous outcomes...
August 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28813148/chitosan-coated-cinnamon-oregano-loaded-solid-lipid-nanoparticles-to-augment-5-fluorouracil-cytotoxicity-for-colorectal-cancer-extracts-standardization-nanoparticles-optimization-and-cytotoxicity-evaluation
#10
Kamel M Kamel, Islam A Khalil, Mostafa E Rateb, Hosieny Elgendy, Seham Elhawary
This study aimed to coat lipid-based-nanocarriers with chitosan to encapsulate nutraceuticals, minimize opsonization and facilitate passive-targeting. Phase-one was concerned with standardization according to WHO. Qualitative-analysis using LC-HRMS/MS investigated the active-constituents especially reported cytotoxic-agents. Cinnamaldehyde and rosmarinic acid was selected to be quantified using HPLC. Phase-two was aimed to encapsulate both extracts in solid lipid nanoparticles (core) and chitosan (shell) to gain the advantages of both materials properties...
August 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28813143/effect-of-structure-and-disorder-on-the-charge-transport-in-defined-self-assembled-monolayers-of-organic-semiconductors
#11
Thomas Schmaltz, Bastian Gothe, Andreas Krause, Susanne Leitherer, Hans-Georg Steinrück, Michael Thoss, Timothy Clark, Marcus Halik
Self-assembled monolayer field-effect transistors (SAMFETs) are not only a promising new type of organic electronic device but also allow uniquely detailed analyses of structure-property correlations. The influence of the morphology on the charge transport is particularly pronounced, due to the confined monolayer of 2D-π-stacked organic semiconductor molecules. The morphology, in turn, is governed by relatively weak van-der-Waals interactions and is thus prone to dynamic structural fluctuations. Accordingly, combining electronic and physical characterization and time-averaged X-ray analyses with the dynamic information available at atomic resolution from simulations, allows us to characterize self-assembled monolayer (SAM-) based devices in unprecedented detail...
August 16, 2017: ACS Nano
https://www.readbyqxmd.com/read/28813136/targeting-of-cellular-organelles-by-fluorescent-plasmid-dna-nanoparticles
#12
Diana Costa, Carolina Costa, Margarida Vaz Caldeira, Luisa Maria Cortes, João A Queiroz, Carla Cruz
The development of a suitable delivery system and the targeting of intracellular organelles are both essential for the success of drug and gene therapies. The conception of fluorescent ligands, displaying targeting specificity together with low toxicity, is an emerging and reliable tool to develop innovative delivery systems. Biocompatible BSA or pDNA/ligand nanoparticles were synthesized by a co-precipitation method and were shown to display adequate sizes and morphology for delivery purposes, and positive surface charges...
August 16, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28813021/enhanced-cell-growth-of-adipocyte-derived-mesenchymal-stem-cells-using-chemically-defined-serum-free-media
#13
Myung-Suk Lee, Christine Youn, Jeong Hyun Kim, Byoung Jun Park, Jongchan Ahn, Sungyoul Hong, Young-Deug Kim, Young Kee Shin, Sang Gyu Park
The multipotency and anti-inflammatory effects of mesenchymal stem cells (MSCs) make them attractive for cell therapy in regenerative medicine. A large number of MSCs is required for efficient therapy owing to the low homing efficiency of MSCs to target sites. Furthermore, owing to limitations in obtaining sufficient amounts of MSCs, in vitro expansion of MSCs that preserves their differentiation and proliferative potential is essential. The animal factor included in culture media also limits clinical application...
August 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28813020/nine-new-triterpene-glycosides-magnumosides-a%C3%A2-a%C3%A2-b%C3%A2-b%C3%A2-c%C3%A2-c%C3%A2-and-c%C3%A2-from-the-vietnamese-sea-cucumber-neothyonidium-massinium-magnum-structures-and-activities-against-tumor-cells-independently-and-in-synergy-with-radioactive-irradiation
#14
Alexandra S Silchenko, Anatoly I Kalinovsky, Sergey A Avilov, Vladimir I Kalinin, Pelageya V Andrijaschenko, Pavel S Dmitrenok, Ekaterina A Chingizova, Svetlana P Ermakova, Olesya S Malyarenko, Tatyana N Dautova
Nine new sulfated triterpene glycosides, magnumosides A₁ (1), A₂ (2), A₃ (3), A₄ (4), B₁ (5), B₂ (6), C₁ (7), C₂ (8) and C₄ (9) as well as a known colochiroside B₂ (10) have been isolated from the tropical Indo-West Pacific sea cucumber Neothynidium (=Massinium) magnum (Phyllophoridae, Dendrochirotida) collected in the Vietnamese shallow waters. The structures of new glycosides were elucidated by 2D NMR spectroscopy and mass-spectrometry. All the isolated new glycosides were characterized by the non-holostane type lanostane aglycones having 18(16)-lactone and 7(8)-double bond and differed from each other by the side chains and carbohydrate moieties structures...
August 16, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28812918/tyrosine-kinase-inhibitors-for-advanced-or-metastatic-thyroid-cancer-a-meta-analysis-of-randomized-controlled-trials
#15
Jen-Wei Liu, Chiehfeng Chen, El-Wui Loh, Chun-Cheng Chu, Mu-Yi Wang, Hsin-Ju Ouyang, Ya-Ting Chang, Wei-Zhan Zhuang, Ching-Wen Chou, Der-Jr Huang, Chia-Hwa Lee, Yun Yen, Ka-Wai Tam
BACKGROUND AND AIMS: Radioiodine-refractory advanced or metastatic thyroid cancer has poor prognosis. We conducted a meta-analysis of randomized controlled trials to evaluate the effectiveness and safety of tyrosine kinase inhibitors (TKIs) for advanced or metastatic thyroid cancer treatment. METHODS: Studies published until April 2017 were selected. The pooled effect size was calculated through meta-analysis by using random effects models. Outcomes were overall survival (OS), progression-free survival (PFS), objective response rate (RR), and adverse events (AEs)...
August 16, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28812882/aberrantly-large-single-channel-conductance-of-polyhistidine-arm-containing-protein-nanopores
#16
Avinash Kumar Thakur, Motahareh Ghahari Larimi, Kristin Gooden, Liviu Movileanu
There have been only a few studies reporting on the impact of polyhistidine affinity tags on the structure, function, and dynamics of proteins. Because of their relatively short size, they are often assumed to have little or no effect on the conformation and activity of a protein. Here, using membrane protein design and single-molecule electrophysiology, we determined that the presence of a hexahistidine arm at the N-terminus of a truncated FhuA-based protein nanopore, leaving the C-terminus untagged, produces an unusual increase in the unitary conductance up to ~8 nS in 1 M KCl...
August 16, 2017: Biochemistry
https://www.readbyqxmd.com/read/28812868/light-and-strong-hierarchical-porous-sic-foam-for-efficient-electromagnetic-interference-shielding-and-thermal-insulation-at-elevated-temperatures
#17
Caiyun Liang, Zhenfeng Wang, Lina Wu, Xiaochen Zhang, Huan Wang, Zhijiang Wang
A novel light but strong SiC foam with hierarchical porous architecture are fabricated by using dough as raw material via carbonization and followed carbothermal reduction with silicon source. A significant synergistic effect is achieved by embedding meso and nano pores in micro-sized porous skeleton, which endows the SiC foam with high-performance electromagnetic interference shielding (EMI), thermal insulation and mechanical properties. The micro-sized skeleton withstands the high stress. The meso- and nano-sized pores enhance the multiple reflection of the incident electromagnetic waves and elongate the path of heat transfer...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28812750/synthesis-and-characterization-of-fe-iii-%C3%AE-oh-zn-ii-complexes-effects-of-a-second-coordination-sphere-and-increase-in-the-chelate-ring-size-on-the-hydrolysis-of-a-phosphate-diester-and-dna
#18
Graciela Aparecida Dos Santos Silva, André Luiz Amorim, Bernardo de Souza, Philipe Gabriel, Hernán Terenzi, Ebbe Nordlander, Ademir Neves, Rosely A Peralta
The synthesis and characterization of three ligands and their respective heterobinuclear Fe(III)Zn(II) complexes were carried out, with the goal of mimicking the active site of purple acid phosphatases (PAPs). The ligand 2-hydroxy-3-(((2-hydroxy-5-methyl-3-(((2-(pyridin-2-yl)ethyl)(pyridin-2-ylmethyl)amino)methyl)benzyl)(pyridin-2ylmethyl)amino)methyl)-5-methylbenzaldehyde (H2L(2)) was synthesized and its complex (Fe(III)Zn(II)L(2)) was used as a basis for comparison with similar complexes previously published in the literature...
August 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28812734/human-behaviour-as-a-long-term-ecological-driver-of-non-human-evolution
#19
REVIEW
Alexis P Sullivan, Douglas W Bird, George H Perry
Due to our intensive subsistence and habitat-modification strategies-including broad-spectrum harvesting and predation, widespread landscape burning, settlement construction, and translocation of other species-humans have major roles as ecological actors who influence fundamental trophic interactions. Here we review how the long-term history of human-environment interaction has shaped the evolutionary biology of diverse non-human, non-domesticated species. Clear examples of anthropogenic effects on non-human morphological evolution have been documented in modern studies of substantial changes to body size or other major traits in terrestrial and aquatic vertebrates, invertebrates, and plants in response to selective human harvesting, urbanized habitats, and human-mediated translocation...
February 21, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812727/exceptionally-preserved-cambrian-loriciferans-and-the-early-animal-invasion-of-the-meiobenthos
#20
Thomas H P Harvey, Nicholas J Butterfield
Microscopic animals that live among and between sediment grains (meiobenthic metazoans) are key constituents of modern aquatic ecosystems, but are effectively absent from the fossil record. We describe an assemblage of microscopic fossil loriciferans (Ecdysozoa, Loricifera) from the late Cambrian Deadwood Formation of western Canada. The fossils share a characteristic head structure and minute adult body size (~300 μm) with modern loriciferans, indicating the early evolution and subsequent conservation of an obligate, permanently meiobenthic lifestyle...
January 30, 2017: Nature ecology & evolution
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