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green tea and bowel diseases

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https://www.readbyqxmd.com/read/27769076/the-role-of-dietary-supplements-in-inflammatory-bowel-disease-a-systematic-review
#1
Roberta E Rossi, Tara Whyand, Charles D Murray, Mark I Hamilton, Dario Conte, Martyn E Caplin
Inflammatory bowel diseases (IBD) are chronic immune disorders of unclear aetiology. Dietary deficiencies may be a potential pathogenic factor in their development. Patients often take food supplements without knowledge of any evidence base. We have therefore assessed the evidence for food supplementation in the management of IBD. A PubMed search was performed for the terms Inflammatory bowel disease; nutritional deficiencies; dietary supplements; curcumin; green tea; vitamin D/other vitamins; folic acid; iron; zinc; probiotics; andrographis paniculata; and boswellia serrate...
December 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27694921/tea-polyphenols-inhibit-the-activation-of-nf-%C3%AE%C2%BAb-and-the-secretion-of-cytokines-and-matrix-metalloproteinases-by-macrophages-stimulated-with-fusobacterium-nucleatum
#2
Amel Ben Lagha, Daniel Grenier
Fusobacterium nucleatum has been associated with both periodontal disease and inflammatory bowel disease. This Gram-negative bacterium possesses a high inflammatory potential that may contribute to the disease process. We hypothesized that green and black tea polyphenols attenuate the inflammatory response of monocytes/macrophages mediated by F. nucleatum. We first showed that the tea extracts, EGCG and theaflavins reduce the NF-κB activation induced by F. nucleatum in monocytes. Since NF-κB is a key regulator of genes coding for inflammatory mediators, we tested the effects of tea polyphenols on secretion of IL-1β, IL-6, TNF-α, and CXCL8 by macrophages...
October 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27366027/favorable-results-from-the-use-of-herbal-and-plant-products-in-inflammatory-bowel-disease-evidence-from-experimental-animal-studies
#3
REVIEW
John K Triantafillidis, Aikaterini Triantafyllidi, Constantinos Vagianos, Apostolos Papalois
The use of herbal therapy for inflammatory bowel disease is increasing worldwide. The aim of this study was to review the available literature on the efficacy of herbal therapy in experimental colitis. All relevant studies published in Medline and Embase up to June 2015 have been reviewed. The results of bowel histology and serum parameters have been recorded. A satisfactory number of published experimental studies, and a quite large one of both herbal and plant products tested in different studies have been reported...
July 2016: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/26968114/epigallocatechin-3-gallate-inhibition-of-myeloperoxidase-and-its-counter-regulation-by-dietary-iron-and-lipocalin-2-in-murine-model-of-gut-inflammation
#4
Beng San Yeoh, Rodrigo Aguilera Olvera, Vishal Singh, Xia Xiao, Mary J Kennett, Bina Joe, Joshua D Lambert, Matam Vijay-Kumar
Green tea-derived polyphenol (-)-epigallocatechin-3-gallate (EGCG) has been extensively studied for its antioxidant and anti-inflammatory properties in models of inflammatory bowel disease, yet the underlying molecular mechanism is not completely understood. Herein, we demonstrate that EGCG can potently inhibit the proinflammatory enzyme myeloperoxidase in vitro in a dose-dependent manner over a range of physiologic temperatures and pH values. The ability of EGCG to mediate its inhibitory activity is counter-regulated by the presence of iron and lipocalin 2...
April 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/26585821/antioxidants-and-vascular-health
#5
REVIEW
Alessandra Bielli, Maria Giovanna Scioli, Donatella Mazzaglia, Elena Doldo, Augusto Orlandi
Oxygen free radicals and other reactive oxygen species (ROS) are common products of normal aerobic cellular metabolism, but high levels of ROS lead to oxidative stress and cellular damage. Increased production of ROS favors vascular dysfunction, inducing altered vascular permeability and inflammation, accompanied by the loss of vascular modulatory function, the imbalance between vasorelaxation and vasoconstriction, and the aberrant expression of inflammatory adhesion molecules. Inflammatory stimuli promote oxidative stress generated from the increased activity of mitochondrial nicotinamide adenine dinucleotide phosphate oxidase, particularly of the Nox4 isoform, with the consequent impairment of mitochondrial β-oxidation...
December 15, 2015: Life Sciences
https://www.readbyqxmd.com/read/26251571/gallic-acid-attenuates-dextran-sulfate-sodium-induced-experimental-colitis-in-balb-c-mice
#6
Ashok Kumar Pandurangan, Nooshin Mohebali, Mohd Esa Norhaizan, Chung Yeng Looi
Gallic acid (GA) is a polyhydroxy phenolic compound that has been detected in various natural products, such as green tea, strawberries, grapes, bananas, and many other fruits. In inflammatory bowel disease, inflammation is promoted by oxidative stress. GA is a strong antioxidant; thus, we evaluated the cytoprotective and anti-inflammatory role of GA in a dextran sulfate sodium (DSS)-induced mouse colitis model. Experimental acute colitis was induced in male BALB/c mice by administering 2.5% DSS in the drinking water for 7 days...
2015: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/25997469/metabolomics-and-proteomics-and-what-to-do-with-all-these-omes-insights-from-nutrigenomic-investigations-in-new-zealand
#7
REVIEW
Matthew Barnett, Wayne Young, Janine Cooney, Nicole Roy
BACKGROUND/AIMS: Nutrigenomics New Zealand has invested considerable effort researching the role of nutrient-gene interactions in human inflammatory bowel disease (IBD). This research has utilised a number of 'omics' techniques, including proteomics and metabolomics. METHODS: Mouse models of intestinal inflammation have been used to investigate the mechanisms underlying IBD and to test foods or food components for potential beneficial effects. Proteomics combining two-dimensional gel electrophoresis with liquid chromatography-mass spectrometry (LC-MS) analysis of peptides, and metabolomics using both gas chromatography-MS and LC-MS have been combined with transcriptomics and microbiome analyses to comprehensively assess samples derived from these models...
2014: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/25986932/a-review-of-the-efficacy-of-dietary-polyphenols-in-experimental-models-of-inflammatory-bowel-diseases
#8
REVIEW
Derek A Martin, Bradley W Bolling
Crohn's disease and ulcerative colitis presently have no cure and are treated with anti-inflammatory drugs or monoclonal antibodies targeting pro-inflammatory cytokines. A variety of rodent models have been used to model chronic and acute colitis. Dietary polyphenols in foods and botanicals are of considerable interest for prevention and treatment of colitis. Many dietary polyphenols have been utilized for prevention of colitis in rodent models. Berries, green tea polyphenols, curcumin, and stilbenes have been the most extensively tested polyphenols in rodent models of colitis...
June 2015: Food & Function
https://www.readbyqxmd.com/read/25601607/the-role-of-dietary-polyphenols-in-the-management-of-inflammatory-bowel-disease
#9
REVIEW
Mohammad H Farzaei, Roja Rahimi, Mohammad Abdollahi
Inflammatory bowel disease (IBD) is an idiopathic chronic, relapsing inflammation of the bowel which is caused by dysregulation of the mucosal immune system. Polyphenols as the secondary plant metabolites universally present in vegetables and fruits and are the most abundant antioxidants in the human diet. There is evidence demonstrating the beneficial health effects of dietary polyphenols. This review criticizes the potential of commonly used polyphenols including apple polyphenol, bilberry anthocyanin, curcumin, epigallocatechin-3-gallate (EGCG) and green tea polyphenols, naringenin, olive oil polyphenols, pomegranate polyphenols and ellagic acid, quercetin, as well as resveratrol specifically in IBD with an emphasis on cellular mechanisms and pharmaceutical aspects...
2015: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/23846486/a-pilot-study-to-evaluate-the-safety-and-efficacy-of-an-oral-dose-of-epigallocatechin-3-gallate-rich-polyphenon-e-in-patients-with-mild-to-moderate-ulcerative-colitis
#10
RANDOMIZED CONTROLLED TRIAL
Gerald W Dryden, Allan Lam, Karen Beatty, Hassan H Qazzaz, Craig J McClain
BACKGROUND: Green tea and its main polyphenolic component, (-)-epigallocatechin-3-gallate (EGCG), exert powerful anti-inflammatory effects that are protective against both inflammatory diseases and cancer. Research with animal and human cell lines provide plausible support for these claims. Poor absorption results in low systemic bioavailability of EGCG after oral administration but high colonic mucosal exposure. METHODS: Patients with mild to moderate ulcerative colitis (UC) were randomized to daily doses of oral Polyphenon E (400 mg or 800 mg of total EGCG daily, administered in split doses) or placebo in a double-blinded, placebo-controlled pilot study...
August 2013: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/23761791/green-tea-polyphenols-and-sulfasalazine-have-parallel-anti-inflammatory-properties-in-colitis-models
#11
Helieh S Oz, Theresa Chen, Willem J S de Villiers
BACKGROUND: There is no cure for autoimmune chronic inflammatory bowel disease (IBD). IBD patients commonly use complementary and alternative medications of which the safety, efficacy, and interaction with standard-of-care therapies are not fully known. Thus the consequences can become life-threatening. Sulfasalazine commonly used in IBD, potentially has severe adverse effects, including infertility, pulmonary fibrosis, lack of response, and ultimately patients may require intestinal resection...
2013: Frontiers in Immunology
https://www.readbyqxmd.com/read/23643524/modulation-of-colonic-inflammation-in-mdr1a-mice-by-green-tea-polyphenols-and-their-effects-on-the-colon-transcriptome-and-proteome
#12
Matthew P G Barnett, Janine M Cooney, Yvonne E M Dommels, Katia Nones, Diane T Brewster, Zaneta Park, Christine A Butts, Warren C McNabb, William A Laing, Nicole C Roy
Animal models are an important tool to understand the complex pathogenesis of inflammatory bowel diseases (IBDs). This study tested the anti-inflammatory potential of a green tea extract rich in polyphenols (GrTP) in the colon of the multidrug resistance targeted mutation (Mdr1a(-/-)) mouse model of IBD. Insights into mechanisms responsible for this reduction in inflammation were gained using transcriptome and proteome analyses. Mice were randomly assigned to an AIN-76A (control) or GrTP-enriched diet. At 21 or 24 weeks of age, a colonic histological injury score was determined for each mouse, colon mRNA transcript levels were assessed using microarrays, and colon protein expression was measured using two-dimensional gel electrophoresis and liquid chromatography-mass spectrometry protein identification...
October 2013: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/22414101/anti-inflammatory-agents-from-plants-progress-and-potential
#13
REVIEW
M C Recio, I Andujar, J L Rios
The identification of substances that can promote the resolution of inflammation in a way that is homeostatic, modulatory, efficient, and well-tolerated by the body is of fundamental importance. Traditional medicines have long provided front-line pharmacotherapy for many millions of people worldwide. Medicinal extracts are a rich source of therapeutic leads for the pharmaceutical industry. The use of medicinal plant therapies to treat chronic illness, including rheumatoid arthritis (RA) and inflammatory bowel disease (IBD), is thus widespread and on the rise...
2012: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/22325177/green-tea-polyphenol-epigallocatechin-3-gallate-shows-therapeutic-antioxidative-effects-in-a-murine-model-of-colitis
#14
Markus Brückner, Sabine Westphal, Wolfram Domschke, Torsten Kucharzik, Andreas Lügering
BACKGROUND AND AIMS: Leukocyte infiltration, up-regulation of proinflammatory cytokines and severe oxidative stress caused by increased amounts of reactive oxygen species are characteristics of inflammatory bowel disease. The catechin (2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol-3-(3,4,5-trihydroxybenzoate), named epigallocatechin-3-gallate, EGCG, has been demonstrated to exert anti-inflammatory and antioxidative properties, reducing reactive oxygen species in the inflamed tissues...
March 2012: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/21881016/pharmaconutrition-for-the-obese-critically-ill-patient
#15
REVIEW
Ryan T Hurt, Thomas H Frazier, Stephen A McClave, Matt C Cave
Obesity is an epidemic that affects approximately 30% of the adult population in the United States. The prevalence of obesity in the critically ill seems to correlate with the rise in obesity in the general population. Delivery of standard enteral nutrition (EN) to patients in the intensive care unit (ICU) has been shown to decrease infectious complications. Obese ICU patients may be at increased risk for infections, ICU length of stay, and ventilation requirements compared to the nonobese. Pharmaconutrition has been shown to decrease many of these negative ICU outcomes...
September 2011: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/21687829/green-tea-polyphenols-mediated-apoptosis-in-intestinal-epithelial-cells-by-a-fadd-dependent-pathway
#16
Helieh S Oz, Jeffrey L Ebersole
Colorectal cancer is the most common malignant complication in patients with chronic inflammatory bowel disease (IBD). In addition, these patients are at risk for developing painful complications during chemotherapy due to cytotoxic effects of drugs currently in use. Past studies have suggested a protective effect of tea consumption on gastrointestinal (GI) malignancies. Green tea polyphenols (GrTP) inhibited carcinogen-induced GI tumors in rodents and induced apoptosis in various carcinoma cell lines. We hypothesized that GrTP and its polyphenolic compounds regulate apoptosis in the intestinal epithelia...
September 2010: Journal of Cancer Therapy
https://www.readbyqxmd.com/read/21603032/emerging-role-of-bioflavonoids-in-gastroenterology-especially-their-effects-on-intestinal-neoplasia
#17
Harald P Hoensch, Reinhard Oertel
Flavonoids, secondary plant products which could be essential for normal physiology in humans and animals, may be the vitamins of the next century. Flavonoids belong to the polyphenols and possess antioxidative, anti-inflammatory, antimutagenic and anticarcinogenic properties. Among the various flavonoid species, tea flavonoids such as apigenin (from camomile) and epigallocatechin gallate (EGCG from green tea) can be used for the prevention of intestinal neoplasia, especially for adenoma and cancer prevention in the gastrointestinal tract...
May 15, 2011: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/21506932/effects-of-antioxidant-polyphenols-on-tnf-alpha-related-diseases
#18
REVIEW
Kiichiro Kawaguchi, Tsukasa Matsumoto, Yoshio Kumazawa
Oxidative stress and inflammatory responses sustained for a long period of time cause many diseases. A proinflammatory cytokine, tumor necrosis factor α (TNF-α), plays a pivotal role in the pathogenesis of chronic and auto-immune diseases. The present review, supplemented by hitherto unpublished data of the authors and their coworkers, shows that the intake of polyphenols contained in natural sources, such as hydroxytyrosol, tyrosol, oleuropein (olives), naringin and hesperidin (Citrus fruits), resveratrol, procyanidins or oligomeric procyanidin (grapes or grape seed extracts), (-)-epigallocatechin gallate (green tea) and quercetin (grapes, green tea) etc...
2011: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/21082353/comparative-evaluation-of-different-doses-of-green-tea-extract-alone-and-in-combination-with-sulfasalazine-in-experimentally-induced-inflammatory-bowel-disease-in-rats
#19
D S Prasad Byrav, B Medhi, K Vaiphei, A Chakrabarti, K L Khanduja
BACKGROUND: The exact etiopathology of inflammatory bowel disease is still unclear. Most of the therapies present are directed towards symptomatic improvement. Surgical therapy in the form of restorative proctocolectomy is reserved for the terminal stage disease, which is unresponsive to medical therapy. The present study was conducted to evaluate the effect of green tea in experimentally induced inflammatory bowel disease. METHODS: A total of 36 animals were included in the study...
May 2011: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/20652470/targeting-of-histamine-producing-cells-by-egcg-a-green-dart-against-inflammation
#20
REVIEW
Esther Melgarejo, Miguel Angel Medina, Francisca Sánchez-Jiménez, José Luis Urdiales
The human body is made of some 250 different cell types. From them, only a small subset of cell types is able to produce histamine. They include some neurons, enterochromaffin-like cells, gastrin-containing cells, mast cells, basophils, and monocytes/macrophages, among others. In spite of the reduced number of these histamine-producing cell types, they are involved in very different physiological processes. Their deregulation is related with many highly prevalent, as well as emergent and rare diseases, mainly those described as inflammation-dependent pathologies, including mastocytosis, basophilic leukemia, gastric ulcer, Crohn disease, and other inflammatory bowel diseases...
September 2010: Journal of Physiology and Biochemistry
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