keyword
https://read.qxmd.com/read/38503153/therapeutic-effects-of-epigallocatechin-3-gallate-for-inflammatory-bowel-disease-a-preclinical-meta-analysis
#1
JOURNAL ARTICLE
Feng Wei, Delin Li, Xiaodong Chen, Yubing Li, Yuting Zeng, Yilin Cai, Youtao Zeng, Yu Chen, Xiao Ma, Jinhao Zeng
BACKGROUND: Epigallocatechin-3-gallate (EGCG), the primary active compound in green tea, is recognized for its significant anti-inflammatory properties and potential pharmacological effects on inflammatory bowel disease (IBD). However, comprehensive preclinical evidence supporting the use of EGCG in treating IBD is currently insufficient. PURPOSE: To evaluate the efficacy of EGCG in animal models of IBD and explore potential underlying mechanisms, serving as a groundwork for future clinical investigations...
February 2, 2024: Phytomedicine
https://read.qxmd.com/read/37969979/virofree-associates-with-the-modulation-of-gut-microbiomes-and-alleviation-of-dss-induced-ibd-symptoms-in-mice
#2
JOURNAL ARTICLE
Wei-Sheng Lin, Wan-Chen Cheng, Min-Hsiung Pan
Inflammatory bowel disease (IBD) is a chronic, nonspecific inflammation of the intestines that primarily comprises Crohn's disease and ulcerative colitis. The incidence and prevalence of IBD have been increasing globally, highlighting the significance of research and prophylactic interventions. Virofree, a mixture of various botanical extracts (including grapes, cherries, olive leaves, marigolds, green tea, and others), has shown significant potential in disease prevention. This study examined the effects of Virofree on intestinal inflammation and the gut microbiota in mice using a dextran sulfate sodium (DSS)-induced model...
November 7, 2023: ACS Omega
https://read.qxmd.com/read/37701897/oxidative-stress-hormones-and-effects-of-natural-antioxidants-on-intestinal-inflammation-in-inflammatory-bowel-disease
#3
REVIEW
Dipak Kumar Sahoo, Romy M Heilmann, Biswaranjan Paital, Ashish Patel, Virendra Kumar Yadav, David Wong, Albert E Jergens
Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal (GI) disorder characterized by intestinal inflammation. The etiology of IBD is multifactorial and results from a complex interplay between mucosal immunity, environmental factors, and host genetics. Future therapeutics for GI disorders, including IBD, that are driven by oxidative stress require a greater understanding of the cellular and molecular mechanisms mediated by reactive oxygen species (ROS). In the GI tract, oxidative stressors include infections and pro-inflammatory responses, which boost ROS generation by promoting the production of pro-inflammatory cytokines...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37242530/the-potential-of-epigallocatechin-3-gallate-egcg-as-complementary-medicine-for-the-treatment-of-inflammatory-bowel-disease
#4
JOURNAL ARTICLE
Sabrina Schnur, Fabian Hans, Annika Dehne, Janina Osti, Malte-Ole Schneemann, Marc Schneider, Marius Hittinger
Complementary and alternative medicine has the potential to enrich conventional therapy to improve the treatment of various diseases. Patients that suffer from inflammatory bowel disease, which requires a constant need for medication, have to deal with the adverse effects of repeated application. Natural products such as Epigallocatechin-3-gallate (EGCG) possess the potential to improve symptoms of inflammatory diseases. We investigated the efficacy of EGCG on an inflamed co-culture model simulating IBD and compared it to the efficacies of four commonly applied active pharmaceutical ingredients...
May 14, 2023: Pharmaceuticals
https://read.qxmd.com/read/36656397/cxcr4-as-possible-druggable-target-linking-inflammatory-bowel-disease-and-parkinson-s-disease
#5
JOURNAL ARTICLE
Nitu Dogra, Ruchi Jakhmola-Mani, Angamba Meetei Potshangbam, Shilpa Buch, Deepshikha Pande Katare
Parkinson's disease (PD) is a chronic, progressive, and second most prevalent neurological disorder affecting the motor system. It has been found that people suffering with inflammatory bowel disease (IBD) are at 22% more risk for PD. In the current study, we have established a molecular link between gut and brain. The microarray gene expression datasets of Homo sapiens were obtained from Gene Expression Omnibus Database. Major genes involved in gut-brain connection were found to be CXCR4, LRRK2, APOE, SNCA, IL6, HIF-1α, ABCA1 etc...
January 19, 2023: Metabolic Brain Disease
https://read.qxmd.com/read/35779147/green-tea-egcg-effectively-alleviates-experimental-colitis-in-middle-aged-male-mice-by-attenuating-multiple-aspects-of-oxi-inflammatory-stress-and-cell-cycle-deregulation
#6
JOURNAL ARTICLE
Bhawna Diwan, Rohit Sharma
Age-dependent increased risk of inflammatory bowel diseases such as ulcerative colitis is being increasingly realized, and yet therapies targeting this disorder within the purview of aging are limited. The present study attempted to assess the efficacy of green tea epigallocatechin gallate (EGCG) consumption in preventing the severity and progression of dextran sulphate sodium (DSS)-induced ulcerative colitis in 18 months old middle-aged male mice. Acute colitis was induced in animals using DSS and protective effects of EGCG consumption were examined...
July 2, 2022: Biogerontology
https://read.qxmd.com/read/35329893/herb-drug-interaction-in-inflammatory-diseases-review-of-phytomedicine-and-herbal-supplements
#7
REVIEW
Annemarie Lippert, Bertold Renner
Many people worldwide use plant preparations for medicinal purposes. Even in industrialized regions, such as Europe, where conventional therapies are accessible for the majority of patients, there is a growing interest in and usage of phytomedicine. Plant preparations are not only used as alternative treatment, but also combined with conventional drugs. These combinations deserve careful contemplation, as the complex mixtures of bioactive substances in plants show a potential for interactions. Induction of CYP enzymes and pGP by St John's wort may be the most famous example, but there is much more to consider...
March 12, 2022: Journal of Clinical Medicine
https://read.qxmd.com/read/34656857/-green-nanotherapeutics-from-tea-leaves-for-orally-targeted-prevention-and-alleviation-of-colon-diseases
#8
JOURNAL ARTICLE
Menghang Zu, Dengchao Xie, Brandon S B Canup, Nanxi Chen, Yajun Wang, Ruxin Sun, Zhan Zhang, Yuming Fu, Fangyin Dai, Bo Xiao
Although synthesized nanotherapeutics (NTs) are attractive for the oral treatment of colon diseases, their clinical translations are constrained by the unsatisfactory therapeutic outcomes, potential adverse effects, and high cost of mass production. Here, we report the development of tea leaf-derived natural NTs with desirable particle sizes (140.0 nm) and negative surface charge (-14.6 mV). These natural exosome-like NTs were found to contain large amounts of lipids, some functional proteins, and many bioactive small molecules...
December 2021: Biomaterials
https://read.qxmd.com/read/34493333/gut-microbiota-from-green-tea-polyphenol-dosed-mice-improves-intestinal-epithelial-homeostasis-and-ameliorates-experimental-colitis
#9
JOURNAL ARTICLE
Zhenhua Wu, Shimeng Huang, Tiantian Li, Na Li, Dandan Han, Bing Zhang, Zhenjiang Zech Xu, Shiyi Zhang, Jiaman Pang, Shilan Wang, Guolong Zhang, Jiangchao Zhao, Junjun Wang
BACKGROUND: Alteration of the gut microbiota may contribute to the development of inflammatory bowel disease (IBD). Epigallocatechin-3-gallate (EGCG), a major bioactive constituent of green tea, is known to be beneficial in IBD alleviation. However, it is unclear whether the gut microbiota exerts an effect when EGCG attenuates IBD. RESULTS: We first explored the effect of oral or rectal EGCG delivery on the DSS-induced murine colitis. Our results revealed that anti-inflammatory effect and colonic barrier integrity were enhanced by oral, but not rectal, EGCG...
September 7, 2021: Microbiome
https://read.qxmd.com/read/33917379/gastroprotective-effects-of-polyphenols-against-various-gastro-intestinal-disorders-a-mini-review-with-special-focus-on-clinical-evidence
#10
REVIEW
Hui-Fang Chiu, Kamesh Venkatakrishnan, Oksana Golovinskaia, Chin-Kun Wang
Polyphenols are classified as an organic chemical with phenolic units that display an array of biological functions. However, polyphenols have very low bioavailability and stability, which make polyphenols a less bioactive compound. Many researchers have indicated that several factors might affect the efficiency and the metabolism (biotransformation) of various polyphenols, which include the gut microbiota, structure, and physical properties as well as its interactions with other dietary nutrients (macromolecules)...
April 6, 2021: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/33635174/therapeutic-implications-of-functional-tea-ingredients-for-ameliorating-inflammatory-bowel-disease-a-focused-review
#11
JOURNAL ARTICLE
Yina Huang, Keyu Xing, Liang Qiu, Qinglong Wu, Hua Wei
Inflammatory bowel disease (IBD) is a chronic gastro-intestinal disorders of unknown etiology. There are several drugs approved for treating IBD patients with active disease, including first-line use of aminosalicylates, and secondary choices of immunomodulators and other therapies. These medications might manage disease symptoms, but have also shown significant side-effects in IBD patients. Tea is the second largest beverage in the world and its main active ingredients including tea polyphenols, polysaccharides and tea pigments have been shown promising anti-inflammatory and antioxidant properties...
February 26, 2021: Critical Reviews in Food Science and Nutrition
https://read.qxmd.com/read/32750449/green-tea-polyphenols-mitigate-the-plant-lectins-induced-liver-inflammation-and-immunological-reaction-in-c57bl-6-mice-via-nlrp3-and-nrf2-signaling-pathways
#12
JOURNAL ARTICLE
Dongxu Wang, Man Zhang, Taotao Wang, Tiantian Liu, Yuanxin Guo, Daniel Granato
Plant-derived dietary lectins have been reported to be involved in the pathogenesis of several inflammatory diseases, including hepatitis, inflammatory bowel disease, diabetes, and celiac disease. In this present study, we aimed to assess whether green tea polyphenols (GTPs) exerts protective effects against plant lectins-induced liver inflammation and immunological reaction in mice. The C57BL/6 mice received intragastric GTPs (200 mg/kg b.w.) once per day for 7 consecutive days prior to plant lectins stimulation (50 mg/kg b...
October 2020: Food and Chemical Toxicology
https://read.qxmd.com/read/32256476/amelioration-of-alcohol-induced-gastric-ulcers-through-the-administration-of-lactobacillus-plantarum-apsulloc-331261-isolated-from-green-tea
#13
JOURNAL ARTICLE
Haryung Park, Donghyun Cho, Eunchong Huang, Ju Yeon Seo, Wan Gi Kim, Svetoslav Dimitrov Todorov, Yosep Ji, Wilhelm Heinrich Holzapfel
Gastric inflammation is an indication of gastric ulcers and possible other underlying gastric malignancies. Epidemiological studies have revealed that several Asian countries, including South Korea, suffer from a high incidence of gastric diseases derived from high levels of stress, alcoholic consumption, pyloric infection and usage of non-steroidal anti-inflammatory drugs (NSAIDs). Clinical treatments of gastric ulcers are generally limited to proton pump inhibitors that neutralize the stomach acid, and the application of antibiotics for Helicobacter pylori eradication, both of which are known to have a negative effect on the gut microbiota...
2020: Frontiers in Microbiology
https://read.qxmd.com/read/31362373/low-dose-epigallocatechin-gallate-alleviates-experimental-colitis-by-subduing-inflammatory-cells-and-cytokines-and-improving-intestinal-permeability
#14
JOURNAL ARTICLE
Yong Du, Huihua Ding, Kamala Vanarsa, Sanam Soomro, Sahar Baig, John Hicks, Chandra Mohan
BACKGROUND: In this study, we investigate the impact of epigallocatechin gallate (EGCG), the most abundant and potent catechin in green tea, on a mouse model of inflammatory bowel disease (IBD) and the underlying mechanisms of action. METHODS: C57BL/6J mice were subjected to dextran sulfate sodium (DSS)-induced IBD-like disease and then randomly divided into three groups: Model group (MD), low-dose EGCG group (LE, 20 mg/kg/d), and high-dose EGCG group (HE, 50 mg/kg/d)...
July 29, 2019: Nutrients
https://read.qxmd.com/read/30935522/green-tea-a-possibility-in-the-therapeutic-approach-of-inflammatory-bowel-diseases-green-tea-and-inflammatory-bowel-diseases
#15
REVIEW
Sandra Maria Barbalho, Henrique Bosso, Letícia M Salzedas-Pescinini, Ricardo de Alvares Goulart
OBJECTIVE: this review aimed to investigate the effects of green tea polyphenols (GTP) in Ulcerative colitis and Crohn´s Disease. MATERIALS AND METHODS: The databases used were MEDLINE-and EMBASE (October 2009 to September 2018). Studies that reported the use of green tea and its effects on IBD were included. RESULTS: Ten articles were included in this review. DISCUSSION: GTP play a role in reducing TNF-α, Interleukin 1β (IL-1β), IL-6, IL-8, and 17; downregulate cyclooxygenase-mediated I kappa B kinase and transcription of NFκB...
April 2019: Complementary Therapies in Medicine
https://read.qxmd.com/read/30410970/green-tea-catechin-dramatically-promotes-rnai-mediated-by-low-molecular-weight-polymers
#16
JOURNAL ARTICLE
Wanwan Shen, Qingwei Wang, Yang Shen, Xiao Gao, Lei Li, Yang Yan, Hui Wang, Yiyun Cheng
Cytosolic delivery is the major challenge that limits the clinical translation of siRNA-based therapeutics. Although thousands of polymers have been developed for siRNA delivery, the efficiency-toxicity correlation is unsatisfactory. Here, we report a facile strategy to fabricate core-shell-structured nanoparticles with robust siRNA delivery efficiency. The nanoparticle is prepared by entropy-driven complexation of siRNA with a green tea catechin to yield a negatively charged core, followed by coating low-molecular-weight polymers to form the shell...
October 24, 2018: ACS Central Science
https://read.qxmd.com/read/29532213/treatment-of-inflammatory-bowel-disease-via-green-tea-polyphenols-possible-application-and-protective-approaches
#17
REVIEW
Sajid Ur Rahman, Yu Li, Yingying Huang, Lei Zhu, Shibin Feng, Jinjie Wu, Xichun Wang
Inflammatory bowel disease (IBD) is a collection of inflammatory conditions of colon and small intestine which affect millions of individuals worldwide and the prevalence amount is on the rise. The organ failure as well as loss of tissue function is because of the inflammatory reaction which is the major contributor of tissue healing leading to lifelong debilitation. To stop the tough consequences of inflammation every patient pursues alternative therapy to relieve symptoms. Green tea polyphenols (GTPs) play significant roles in down regulating signaling pathways because GTPs exert effective antioxidant properties and regulate Toll-like receptor 4 (TLR4) expression via certain receptor, inhibited endotoxin-mediated tumor necrosis factor alpha (TNF-α) production by blocking transcription nuclear factor-kappa B (NF-kB) activation and upstream of mediated I kappa B kinase complex pathway activities, as well as intrusion with the flow of cytokines and synthesis of cyclooxygenase-2 (COX-2)...
April 2018: Inflammopharmacology
https://read.qxmd.com/read/29383023/of-mice-and-men-a-novel-dietary-supplement-for-the-treatment-of-ulcerative-colitis
#18
JOURNAL ARTICLE
Shiran Shapira, Ari Leshno, Daniel Katz, Nitsan Maharshak, Gil Hevroni, Maayan Jean-David, Sarah Kraus, Lior Galazan, Ilan Aroch, Dina Kazanov, Aharon Hallack, Stewart Becker, Mark Umanski, Menachem Moshkowitz, Iris Dotan, Nadir Arber
BACKGROUND: Curcumin, green tea polyphenols and selenium possess anti-inflammatory and anti-oxidant properties. Individually they have demonstrated some efficacy in animal models and human subjects with inflammatory bowel disease (IBD). To evaluate the efficacy and safety of Coltect [Curcumin (500 mg), green tea (250 mg) and selenium (100 µg)] in vivo and in patients with ulcerative colitis (UC). METHODS: Each component was compared to placebo in a DSS mice colitis model...
2018: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/28322293/tea-polyphenols-inhibit-the-growth-and-virulence-properties-of-fusobacterium-nucleatum
#19
JOURNAL ARTICLE
Amel Ben Lagha, Bruno Haas, Daniel Grenier
Fusobacterium nucleatum plays a key role in creating the pathogenic subgingival biofilm that initiates destructive periodontitis. It is also a common resident of the human gastrointestinal tract and has been associated with inflammatory bowel disease. The aim of the present study was to investigate the effects of green and black tea extracts as well as two of their bioactive components, EGCG and theaflavins, on the growth and virulence properties of F. nucleatum. The tea extracts and components displayed various degrees of antibacterial activity that may involve damage to the bacterial cell membrane and the chelation of iron...
March 21, 2017: Scientific Reports
https://read.qxmd.com/read/27769076/the-role-of-dietary-supplements-in-inflammatory-bowel-disease-a-systematic-review
#20
REVIEW
Roberta E Rossi, Tara Whyand, Charles D Murray, Mark I Hamilton, Dario Conte, Martyn E Caplin
Inflammatory bowel diseases (IBD) are chronic immune disorders of unclear aetiology. Dietary deficiencies may be a potential pathogenic factor in their development. Patients often take food supplements without knowledge of any evidence base. We have therefore assessed the evidence for food supplementation in the management of IBD. A PubMed search was performed for the terms Inflammatory bowel disease; nutritional deficiencies; dietary supplements; curcumin; green tea; vitamin D/other vitamins; folic acid; iron; zinc; probiotics; andrographis paniculata; and boswellia serrate...
December 2016: European Journal of Gastroenterology & Hepatology
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