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https://www.readbyqxmd.com/read/28196391/pentoxifylline-treatment-of-very-low-birth-weight-neonates-with-nosocomial-sepsis
#1
Şahin Hamilçıkan, Emrah Can, Övgü Büke, Meltem Erol, Özlem Bostan Gayret
Objective The objective of this study was to assess the result of intravenous pentoxifylline as an adjunct to antibiotic therapy on mortality and morbidity in very low birth weight (VLBW) preterm neonates with nosocomial sepsis. Methods For the 18 VLBW preterm neonates, as an adjunct therapy to antibiotics regimens, pentoxifylline (5 mg/kg/h for 6 hours) was administered to premature infants with sepsis on 3 successive days. Clinical and laboratory parameters were recorded before and after treatment. Results Following pentoxifylline therapy, the immature-to-total neutrophil ratio and C-reactive protein (CRP) levels were significantly decreased, while the blood pH and base excess were significantly increased (p < 0...
February 14, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28155332/reducing-antibiotic-exposure-in-suspected-neonatal-sepsis
#2
Christopher Henry Grant, Andrew Arnott, Tim Brook, Alice Horne, William Hurst, Sarah Kelly, Christina Lang, Madeleine Payne, Hannah Pert, Sarah Sparrow, Pakaye Anne Dokubo, Natalie Bee, Ruth Gibbs, Julie-Clare Becher
Prolonged antibiotic therapy is associated with antimicrobial resistance and increased mortality in preterm infants. We evaluated the impact of an automatic stop order (ASO) and C-reactive protein (CRP) on the duration of antibiotics and level of intervention in infants screened for early-onset sepsis who had negative cultures. We introduced an ASO for low-risk infants, then, consequently, for all infants treated for suspected sepsis. We subsequently introduced a single CRP measurement at 36 hours. Between 2011 and 2014, 4 time periods were studied, at baseline and after each intervention...
January 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28131458/biomarkers-for-the-diagnosis-of-neonatal-sepsis-and-necrotizing-entercolitis-clinical-practice-guidelines
#3
Margaret Gilfillan, Vineet Bhandari
Sepsis and necrotizing enterocolitis are major contributors to morbidity and mortality in neonates, especially in those born preterm. While therapeutic interventions are available for both (for e.g. antibiotics), a major dilemma is early diagnosis so that these interventions can be done in a timely manner. As clinical evaluation alone is unreliable in identifying infants in the early stages of neonatal sepsis or necrotizing enterocolitis, there is a need to find specific biomarkers associated with these conditions to improve diagnostic capabilities...
January 25, 2017: Early Human Development
https://www.readbyqxmd.com/read/28045978/cord-blood-acute-phase-reactants-predict-early-onset-neonatal-sepsis-in-preterm-infants
#4
Leena B Mithal, Hannah L Palac, Ram Yogev, Linda M Ernst, Karen K Mestan
BACKGROUND: Early onset sepsis (EOS) is a major cause of morbidity and mortality in preterm infants, yet diagnosis remains inadequate resulting in missed cases or prolonged empiric antibiotics with adverse consequences. Evaluation of acute phase reactant (APR) biomarkers in umbilical cord blood at birth may improve EOS detection in preterm infants with intrauterine infection. METHODS: In this nested case-control study, infants (29.7 weeks gestation, IQR: 27.7-32...
2017: PloS One
https://www.readbyqxmd.com/read/27925621/presepsin-for-the-detection-of-early-onset-sepsis-in-preterm-newborns
#5
Paolo Montaldo, Roberto Rosso, Alfredo Santantonio, Giovanni Chello, Paolo Giliberti
BACKGROUND: Early-onset sepsis (EOS) is responsible for an important fraction of neonatal morbidity and mortality all over the world. The aim of this study was to assess whether presepsin (P-SEP) can be a more accurate biomarker of EOS compared with pro-calcitonin (PCT) and C-reactive protein (CRP). STUDY DESIGN: Consecutive preterm neonates (<34 wk gestational age, admitted to Neonatal Intensive Care Unit by 6 h of age and undergoing sepsis evaluation) were recruited as part of a case-matched control study...
December 7, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27908399/serum-copper-concentrations-in-hospitalized-newborns
#6
Ricardo González-Tarancón, Luisa Calvo-Ruata, Maite Aramendía, Carmen Ortega, Elena García-González, Luis Rello
BACKGROUND: Low serum Cu and ceruloplasmin (Cp) concentrations in newborns can be the first indication of a severe Cu deficient intake or, alternatively, of genetic diseases affecting Cu metabolism. However, Cu and Cp concentrations can also be influenced by other variables that render their quantitative results difficult to interpret. Therefore, it is necessary to identify these variables and stratify Cu and Cp concentrations according to these altering factors. METHODS: Serum Cu and Cp concentrations for 564 hospitalized newborns (0-12days of life) are stratified according to their age, prematurity (birth weight or gestational age), type of feeding and inflammatory state (assessed by the serum high sensitivity C-reactive protein (hs-CRP) level) to identify potential correlations...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27631399/aggressive-posterior-retinopathy-of-prematurity-is-associated-with-multiple-infectious-episodes-and-thrombocytopenia
#7
Pia Lundgren, Linnea Lundberg, Gunnel Hellgren, Gerd Holmström, Anna-Lena Hård, Lois E Smith, Agneta Wallin, Boubou Hallberg, Ann Hellström
BACKGROUND: The most severe form of rapidly progressing retinopathy of prematurity (ROP) is termed aggressive posterior ROP (APROP). APROP frequently causes severe visual impairment in affected preterm infants despite timely and appropriate laser treatment. OBJECTIVES: We investigated the postnatal characteristics associated with APROP development in a national Swedish cohort. METHODS: This retrospective, 1:1 matched case-control study included all infants that developed APROP in zone 1 (n = 9) between 2008 and 2012...
2017: Neonatology
https://www.readbyqxmd.com/read/27547966/an-elevation-of-serum-ferritin-level-might-increase-clinical-risk-for-the-persistence-of-patent-ductus-arteriosus-sepsis-and-bronchopulmonary-dysplasia-in-erythropoietin-treated-very-low-birth-weight-infants
#8
Masayuki Ochiai, Hiroaki Kurata, Hirosuke Inoue, Koichi Tanaka, Yuki Matsushita, Junko Fujiyoshi, Yoshifumi Wakata, Kiyoko Kato, Tomoaki Taguchi, Hidetoshi Takada
BACKGROUND: The substantial risk of iron overload is not routinely monitored in most of the neonatal intensive care units (NICUs) in Japan; however, blood transfusion is an essential strategy for successfully treating preterm low-birth-weight infants. OBJECTIVE: The aim of this study was to investigate the iron status and clinical features of infants with a birth weight of <1,500 g, i.e. very-low-birth-weight infants (VLBWIs). METHODS: This prospective observational study enrolled 176 (82...
2017: Neonatology
https://www.readbyqxmd.com/read/27478518/comparison-between-pathogen-associated-laboratory-and-clinical-parameters-in-early-onset-sepsis-of-the-newborn
#9
Bernhard Resch, Renoldner B, Hofer N
OBJECTIVES: To identify laboratory and clinical characteristics of different pathogens associated with early-onset sepsis (EOS) of the newborn. METHODS: Newborns with EOS were retrospectively analyzed regarding laboratory and clinical parameters associated with the identified pathogen. RESULTS: We identified 125 newborns having diagnosis of culture proven EOS between 1993 and 2011. One hundred cases had diagnosis of group B streptococci (GBS) infection (80%), 11 had Escherichia coli (8...
2016: Open Microbiology Journal
https://www.readbyqxmd.com/read/27187184/hyperoxia-mediated-lc3b-activation-contributes-to-the-impaired-transdifferentiation-of-type-ii-alveolar-epithelial-cells-aeciis-to-type-i-cells-aecis
#10
Liang Zhang, Shuang Zhao, Lijie Yuan, Hongmin Wu, Hong Jiang, Gang Luo
Life-saving mechanical ventilation can also cause lung injury through the overproduction of reactive oxygen species (ROS), leading to bronchopulmonary dysplasia (BPD)-like symptoms in preterm infants. It is reported that the autophagic protein microtubule-associated protein-1 light chain (LC)-3B can confer protection against hyperoxia-induced DNA damage in lung alveolar epithelium. However, its role in the transdifferentiation of type II alveolar epithelial cells (AECIIs) to type I cells (AECIs) is unclear and requires further investigation...
September 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27048042/combination-of-selected-biochemical-markers-and-cervical-length-in-the-prediction-of-impending-preterm-delivery-in-symptomatic-patients
#11
M Hadži-Legal, A Daneva Markova, M Stefanovic, M Tanturovski
The pathophysiology of preterm delivery (PTD) is complex and multifactorial.It occurs in 8-12% of all deliveries, and the rate of PTD has increased during the past years in spite of intensive efforts towards early detection and prompt treatment. Fifty-eight pregnant women were eligible to join the study if they attended the University Clinic for Gynecology and Obstetrics, Skopje and were admitted to Department of High Risk pregnancy Unit with symptoms of preterm labor (PTL) (symptoms of uterine activity judged by the assessing physician to be indicative of PTL) at 24...
2016: Clinical and Experimental Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27004493/predictive-factors-of-iron-depletion-in-late-preterm-infants-at-the-postnatal-age-of-6-weeks
#12
M D Akkermans, L Uijterschout, M Abbink, P Vos, L Rövekamp-Abels, B Boersma, J B van Goudoever, F Brus
BACKGROUND/OBJECTIVES: Late preterm infants (born ⩾32 weeks of gestation) are at risk for developing iron deficiency and iron deficiency anaemia, and this may lead to impaired neurodevelopment. In the Netherlands, there is no guideline for standardised iron supplementation in these infants. Individualised iron supplementation has been suggested (that is, treating those infants with the highest risk), but risk factors for deprived iron stores in this specific group of infants are not well documented...
August 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27002899/inflammation-lipids-and-aortic-intima-media-thickness-in-newborns-following-chorioamnionitis
#13
Anthony R Rafferty, Lorraine McGrory, Michael Cheung, Sheryle Rogerson, Diana Ziannino, Jan Pyman, Peter G Davis, David Burgner
AIM: This study investigated whether chorioamnionitis was associated with increased inflammation, dyslipidaemia and adverse cardiovascular phenotypes in the immediate postnatal period. METHODS: This prospective case-control study included preterm infants (30(+0) -35(+6) weeks gestational age, GA) whose mothers did not have pregnancy-related conditions that may influence outcomes. Chorioamnionitis was diagnosed by placental histology, and infants were divided retrospectively into cases (chorioamnionitis-exposed) and controls (unexposed)...
July 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/26882580/early-onset-sepsis
#14
REVIEW
Kyrsten Johnson, Stephen Messier
Early onset sepsis (EOS) is a worrisome, life-threatening condition in newborns with onset during the first week of life. Evaluation can be challenging due to the dynamic nature of the condition as the infant transitions to life ex-utero. Symptoms/signs can be nonspecific, thus, a high index of suspicion is warranted for subtle changes in condition including poor feeding, respiratory distress, or decreased activity. Common risk factors include chorioamnionitis, maternal fever, group B strep (GBS) colonization and preterm delivery...
January 2016: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/26865074/c-reactive-protein-increases-with-gestational-age-during-pregnancy-among-chinese-women
#15
Zuguo Mei, Hongtian Li, Mary K Serdula, Rafael C Flores-Ayala, Linlin Wang, Jian-Meng Liu, Laurence M Grummer-Strawn
OBJECTIVE: To examine the concentration of C-reactive protein (CRP) in relation to gestational weeks during pregnancy among Chinese women. METHODS: From a randomized control trial of prenatal supplementation with folic acid, iron-folic acid, and multiple micronutrients in China, we examined 834 pregnant women with CRP measured initially between 5 and 20 weeks and at follow-up between 28 and 32 weeks gestation. We calculated and plotted CRP geometric means by gestational weeks...
July 2016: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/26806147/preterm-labor-and-neonatal-sepsis-caused-by-intrauterine-helicobacter-cinaedi-infection
#16
Yohei Maki, Seishi Furukawa, Yuki Kodama, Kaeko Sumiyoshi, Emi Kino, Hiroshi Sameshima
Helicobacter cinaedi is a rare pathogen but known to cause bacteremia, cellulitis and enterocolitis. Recently, cases of involving various organs are increasingly reported such as endocarditis, meningitis, and kidney cyst infection. We report a case of intrauterine H. cinaedi infection leading preterm birth and neonatal sepsis. A 29-year-old pregnant women who was no underlying disease hospitalized due to threatened preterm labor at 22 weeks of gestation. Clinical findings showed uterine tenderness, fever, leukocytosis and elevated C-reactive protein...
June 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/26753490/interleukin-6-and-c-reactive-protein-levels-in-the-amniotic-fluid-as-indicators-of-preterm-delivery-in-turkish-women
#17
M Öz, B Polat, E Özgü, K D Seçkin, C Taşin, N Danişman
OBJECTIVE: The aim of this study was to determine the value of amniotic fluid interleukin-6 (IL-6) and C-reactive protein (CRP) levels in the prediction of preterm delivery in singleton pregnancies without any known risk factors for preterm delivery in Turkish women. MATERIALS AND METHODS: Patients in the present perinatology department who underwent mid-trimester genetic amniocentesis due to evidence of increased risk of aneuploidy in their prenatal serum screening tests were included in the study...
2015: Clinical and Experimental Obstetrics & Gynecology
https://www.readbyqxmd.com/read/26720209/presepsin-soluble-cd14-subtype-reference-ranges-of-a-new-sepsis-marker-in-term-and-preterm-neonates
#18
Lorenza Pugni, Carlo Pietrasanta, Silvano Milani, Claudia Vener, Andrea Ronchi, Mariella Falbo, Milena Arghittu, Fabio Mosca
OBJECTIVE: Presepsin (soluble CD14 subtype) has been shown to be beneficial as a sepsis marker in adults. Nevertheless, very few data are available in neonates. The aim of the present study was to determine reference ranges of presepsin in term and preterm neonates. METHODS: Healthy term neonates and preterm neonates without clinical signs of infection admitted to the Neonatal Unit were consecutively enrolled. Presepsin concentrations in whole blood were measured using a point-of-care assay system located in the Unit...
2015: PloS One
https://www.readbyqxmd.com/read/26701838/bird-s-eye-view-of-a-neonatologist-clinical-approach-to-emergency-neonatal-infection
#19
REVIEW
Fu-Kuei Huang, Hsiu-Lin Chen, Peng-Hong Yang, Hung-Chih Lin
Though the incidence of neonatal infection in term and near-term infants is relatively low, incidence of infection in preterm very low birth weight infants is as high as 20-30% and may result in neurodevelopmental impairment or mortality. Pediatricians should be familiar with recognition and emergency management of life-threatening neonatal infections, such as congenital pneumonia, early onset sepsis, late onset sepsis, bacterial and fungal meningitis, disseminated neonatal herpes simplex virus (HSV), and HSV meningoencephalitis...
2016: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/26671826/inflammation-high-sensitivity-c-reactive-protein-and-persistent-patent-ductus-arteriosus-in-preterm-infants
#20
Macarena Hillman, Leonardo Meinarde, Alina Rizzotti, Eduardo Cuestas
No abstract text is available yet for this article.
January 2016: Revista Española de Cardiología
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