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https://www.readbyqxmd.com/read/29789348/gestational-low-protein-intake-enhances-whole-kidney-mir-192-and-mir-200-family-expression-and-epithelial-to-mesenchymal-transition-in-rat-adult-male-offspring
#1
Letícia B Sene, Victor Hugo Gonçalves Rizzi, José A R Gontijo, Patricia A Boer
Studies have shown that adult offspring of mothers fed a protein-restricted diet during pregnancy present a pronounced reduction of nephron number associated with decreased fractional urinary sodium excretion and arterial hypertension. Additionally, recent advances in our understanding of the molecular pathways that govern the association of gestational nutritional restriction, intrauterine growth retardation and inflammation with impaired nephrogenesis, nephron underdosing and kidney fibrosis point to the epithelial to mesenchymal transition (EMT) as a common factor...
May 22, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29784613/cryoglobulinemic-glomerulonephritis-associated-with-nodal-and-renal-infiltration-by-t-cell-lymphoma-of-t-follicular-helper-phenotype-a-case-report
#2
Jennifer Li, Marille Umakanathan, Chow Heok P'ng, Winny Varikatt, Fiona Kwok, Ming-Wei Lin, Mirna Vucak-Dzumhur
We present a unique case of cryoglobulinemic glomerulonephritis associated with nodal and renal infiltration by T-cell lymphoma of T-follicular helper phenotype. The patient presented with transient neurologic symptoms, severe nephritic syndrome with nephrotic-range proteinuria, and acute kidney injury. He had elevated double-stranded DNA levels, low complement levels, detectable cryoglobulin, and detectable immunoglobulin M (IgM) paraprotein. The kidney biopsy showed cryoglobulinemic glomerulonephritis with a membranoproliferative pattern and diffuse interstitial infiltrates on light microscopy; IgM, C3 but weak IgG, C1q, and negative C4d staining on immunofluorescence; and deposits with organized substructures on electron microscopy...
May 18, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29781524/tgf-%C3%AE-signalling-in-renal-fibrosis-from-smads-to-non-coding-rnas
#3
Patrick Ming-Kuen Tang, Ying-Ying Zhang, Thomas Shiu-Kwong Mak, Philip Chiu-Tsun Tang, Xiao-Ru Huang, Hui-Yao Lan
Transforming growth factor-β (TGF-β) is the key player in tissue fibrosis. However, antifibrotic therapy targeting this multifunctional protein may interfere other physiological processes to cause side effects. Thus, precise therapeutic targets are needed to be identified by further understanding the underlying mechanisms of TGF-β1 signalling during fibrogenesis. Equilibrium of Smad signalling is crucial for TGF-β-mediated renal fibrosis, where Smad3 is pathogenic but Smad2 and Smad7 are protective. The activation of TGF-β1/Smad signalling triggers extracellular matrix deposition, and local myofibroblast generation and activation...
May 21, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29775762/aortic-vascular-calcification-is-inversely-associated-with-the-trabecular-bone-score-in-patients-receiving-dialysis
#4
Jasna Aleksova, Samantha Kurniawan, Mirna Vucak-Dzumhur, Peter Kerr, Peter R Ebeling, Frances Milat, Grahame J Elder
INTRODUCTION: Progressive chronic kidney disease (CKD) confers a marked increase in risk for vascular calcification, cardiovascular disease, fracture and mortality, with likely contributing factors including dysregulated bone metabolism and mineral homeostasis. In general population studies, increased vascular calcification is directly related to mortality and inversely related to bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA). In patients with CKD, abnormalities in turnover, mineralization and bone volume, reduce the ability of DXA to predict fracture...
May 15, 2018: Bone
https://www.readbyqxmd.com/read/29750148/expression-and-regulation-profile-of-mature-microrna-in-the-pig-relevance-to-xenotransplantation
#5
REVIEW
Zongpei Song, David K C Cooper, Zhiming Cai, Lisha Mou
The pig is an important source of meat production and provides a valuable model for certain human diseases. MicroRNA (miRNA), which is noncoding RNA and regulates gene expression at the posttranscriptional level, plays a critical role in various biological processes. Studies on identification and function of mature miRNAs in multiple pig tissues are increasing, yet the literature is limited. Therefore, we reviewed current research to determine the miRNAs expressed in specific pig tissues that are involved in carcass values (including muscle and adipocytes), reproduction (including pituitary, testis, and ovary), and development of some solid organs (e...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29739062/new-molecular-and-epigenetic-expressions-as-novel-biomarkers-in-critically-ill-polytrauma-patients-with-acute-kidney-injury-aki
#6
REVIEW
Mihaela V Ivan, Alexandru F Rogobete, Ovidiu H Bedreag, Marius Papurica, Sonia E Popovici, Anca Dinu, Mihai Sandesc, Andrei Beceanu, Lavinia M Bratu, Calin M Popoiu, Dorel Sandesc, Ovidiu Boruga, Lazar Fulger
BACKGROUND: A high percentage of the critically ill polytrauma patients develop acute kidney injury (AKI) secondary to trauma and are therefore prone to high morbidity and mortality rates. One of the main objectives in these cases is the fast detection of the condition and continuous rigorous monitoring of the patients. Currently the panel of biomarkers available for monitoring and for the prognosis of AKI is limited. Numerous studies have proven the importance of microRNAs in this field...
May 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29739042/potential-value-of-urinary-exosome-derived-let-7c-5p-in-the-diagnosis-and-progression-of-type-ii-diabetic-nephropathy
#7
Weite Li, Shuo Yang, Rui Qiao, Jie Zhang
BACKGROUND: Diabetic nephropathy (DN) is a leading cause of death worldwide. Reliable biomarkers are demanded for the non-invasive diagnosis of DN. This study aims to investigate whether miRNA in urinary exosomes could serve as a potential biomarker in the diagnosis and progression of DN. METHODS: Urine samples were collected from fifteen healthy controls, twenty type II diabetes without DN and twenty-eight type II patients with DN who underwent kidney biopsy. Differential centrifugation was used to isolate exosomes from urine samples and exosomes were confirmed by electron microscopy, nanoparticle tracking analysis (NTA), and western blot...
May 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29725042/reduced-autophagy-by-a-microrna-mediated-signaling-cascade-in-diabetes-induced-renal-glomerular-hypertrophy
#8
Supriya Deshpande, Maryam Abdollahi, Mei Wang, Linda Lanting, Mitsuo Kato, Rama Natarajan
Autophagy plays a key role in the pathogenesis of kidney diseases, however its role in diabetic nephropathy (DN), and particularly in kidney glomerular mesangial cells (MCs) is not very clear. Transforming Growth Factor- β1 (TGF-β), a key player in the pathogenesis of DN, regulates expression of various microRNAs (miRNAs), some of which are known to regulate the expression of autophagy genes. Here we demonstrate that miR-192, induced by TGF-β signaling, plays an important role in regulating autophagy in DN...
May 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29721069/release-of-micrornas-into-body-fluids-from-ten-organs-of-mice-exposed-to-cigarette-smoke
#9
Alberto Izzotti, Mariagrazia Longobardi, Sebastiano La Maestra, Rosanna T Micale, Alessandra Pulliero, Anna Camoirano, Marta Geretto, Francesco D'Agostini, Roumen Balansky, Mark Steven Miller, Vernon E Steele, Silvio De Flora
Purpose : MicroRNAs are small non-coding RNAs that regulate gene expression, thereby playing a role in a variety of physiological and pathophysiological states. Exposure to cigarette smoke extensively downregulates microRNA expression in pulmonary cells of mice, rats, and humans. Cellular microRNAs are released into body fluids, but a poor parallelism was previously observed between lung microRNAs and circulating microRNAs. The purpose of the present study was to validate the application of this epigenetic biomarker by using less invasive collection procedures...
2018: Theranostics
https://www.readbyqxmd.com/read/29717107/exendin-4-ameliorates-high-glucose-induced-fibrosis-by-inhibiting-the-secretion-of-mir-192-from-injured-renal-tubular-epithelial-cells
#10
Yijie Jia, Zongji Zheng, Meiping Guan, Qian Zhang, Yang Li, Ling Wang, Yaoming Xue
Extracellular vesicles (EVs), which contain microRNA (miRNA), constitute a novel means of cell communication that may contribute to the inevitable expansion of renal fibrosis during diabetic kidney disease (DKD). Exendin-4 is effective for treating DKD through its action on GLP1R. However, the effect of exendin-4 on EV miRNA expression and renal cell communication during the development of DKD remains unknown. In this study, we found that EVs derived from HK-2 cells pre-treated with exendin-4 and high glucose (Ex-HG), which were taken up by normal HK-2 cells, resulted in decreased levels of FN and Col-I compared with EVs from HK-2 cells pre-treated with HG alone...
May 1, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29713834/the-phenotypic-effects-of-exosomes-secreted-from-distinct-cellular-sources-a-comparative-study-based-on-mirna-composition
#11
Scott Ferguson, Sera Kim, Christine Lee, Michael Deci, Juliane Nguyen
Exosomes are nano-sized vesicles composed of lipids, proteins, and nucleic acids. Their molecular landscape is diverse, and exosomes derived from different cell types have distinct biological activities. Since exosomes are now being utilized as delivery vehicles for exogenous therapeutic cargoes, their intrinsic properties and biological effects must be understood. We performed miRNA profiling and found substantial differences in the miRNA landscape of prostate cancer (PC3) and human embryonic kidney (HEK) 293 exosomes with little correlation in abundance of common miRNAs (R2  = 0...
April 30, 2018: AAPS Journal
https://www.readbyqxmd.com/read/29707000/microrna-and-microvascular-complications-of-diabetes
#12
REVIEW
F Barutta, S Bellini, R Mastrocola, G Bruno, G Gruden
In the last decade, miRNAs have received substantial attention as potential players of diabetes microvascular complications, affecting the kidney, the retina, and the peripheral neurons. Compelling evidence indicates that abnormally expressed miRNAs have pivotal roles in key pathogenic processes of microvascular complications, such as fibrosis, apoptosis, inflammation, and angiogenesis. Moreover, clinical research into innovative both diagnostic and prognostic tools suggests circulating miRNAs as possible novel noninvasive markers of diabetes microvascular complications...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29699633/mir-17-92-ameliorates-renal-ischemia-reperfusion-injury
#13
Turun Song, Mianzhi Chen, Zhengsheng Rao, Yang Qiu, Jinpeng Liu, Yamei Jiang, Zhongli Huang, Xianding Wang, Tao Lin
There is limited information on the role of miR-17-92 in renal tubular pathophysiology. Therefore, the present study was performed to determine whether miR-17-92 plays a role in ischemia-reperfusion injury (IRI)-induced acute kidney injury. We originally demonstrated that miR-17-92 is up-regulated following IRI in vivo. To explore the roles of miR-17-92 in the IRI process, we first generated a renal proximal tubule-specific miR-17-92 deletion (PT-miR-17-92-/- ) knockout mouse model with Cre driven by the Kap promoter...
May 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29699373/evaluating-the-oncogenic-and-tumor-suppressor-role-of-xpo5-in-different-tissue-tumor-types
#14
Munazza Khan, Zafaruddin Khan, Yaser Uddin, Sadaf Mustafa, Irfan Shaukat, Jianbo Pan, Naseruddin Höti
The miRNAs nuclear export protein XPO5 has been previously studied in several individual malignancies. In our recent study we have demonstrated that excess levels of XPO5 enhanced the proliferation of prostate cancer cells. Similarly, there are studies to support the inhibitory role of XPO5 in cancers. In order to evaluate discrepancies in the expression levels of XPO5 in differential tumor types, we quantified the expression of XPO5 using gene expression RNA-seq data for several tumor types which were independently confirmed by immunohistochemistry in multiple organs cancer tissue microarray (TMAs) experiment...
April 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29695508/ankyrin-repeat-and-single-kh-domain-1-ankhd1-drives-renal-cancer-cell-proliferation-via-binding-to-and-altering-a-subset-of-mirnas
#15
Maria Fragiadaki, Martin P Zeidler
Clear cell Renal Cell Carcinoma (ccRCC) represents the most common kidney cancer worldwide. Increased cell proliferation associated with abnormal microRNA (miRNA) regulation are hallmarks of carcinogenesis. Ankyrin repeat and single KH domain 1 (ANKHD1) is a highly conserved protein found to interact with core cancer pathways in Drosophila, however its involvement in RCC is completely unexplored. Quantitative PCR studies coupled with large-scale genomics data analyses demonstrated that ANKHD1 is significantly upregulated in kidneys of RCC patients when compared to healthy controls...
April 25, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29687157/hnmda-heterogeneous-network-based-mirna-disease-association-prediction
#16
Li-Hong Peng, Chuan-Neng Sun, Na-Na Guan, Jian-Qiang Li, Xing Chen
Recently, accumulating evidences have shown that microRNAs (miRNAs) could play key roles in the development and progression of multiple important human diseases. Nonetheless, due to the shortcoming of being expensive and time-consuming existing in experimental approaches, computational methods are needed for the prediction of potential miRNA-disease associations. In our study, we proposed a computational model named Heterogeneous Network-based MiRNA-Disease Association prediction (HNMDA) for the latent miRNA-disease association prediction by integrating known miRNA-disease associations, miRNA functional similarity, disease semantic similarity and Gaussian interaction profile kernel similarity...
April 23, 2018: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/29673975/tlr-2-il-10-and-il-17-mediated-immunity-in-experimental-chemotherapy-murine-model-of-systemic-candidiasis-cyclophosphamides-impact-and-roles
#17
Parvin Dehghan, Sepideh Tolouie, Behzad Baradaran, Sanam Nami, Hamid Morovati
The majority of immune components such as Toll-like receptor (TLR)-2, interleukin (IL)-17, neutrophils, and IL-10 play pivotal roles in immunity to Candida albicans (C. albicans) through identifying and launching inflammatory and regulatory responses. Chemotherapy is one of the most potent risk factors for systemic candidiasis through inducing immunosuppression (mostly cyclophosphamide induced immunosuppression) and there is a sensible lack of study around the immunity to C. albicans in such a situation. In this study, following the establishment of infection and immunosuppression in Balb/c mice model, the mRNA/protein levels of TLR-2, IL-10, IL-17, and Myeloperoxidase (MPO) in serum/kidney were measured using Real-time PCR and ELISA respectively...
April 16, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29669307/long-non-coding-rna-neat1-plays-an-important-role-in-sepsis-induced-acute-kidney-injury-by-targeting-mir-204-and-modulating-the-nf-%C3%AE%C2%BAb-pathway
#18
REVIEW
Yi Chen, Jialing Qiu, Bin Chen, Youping Lin, Yulan Chen, Guojin Xie, Junming Qiu, Huasheng Tong, Dongxin Jiang
This study aimed to explore the role of long non-coding RNA NEAT1 in sepsis-induced acute kidney injury (AKI). The expression levels of NEAT1 in sepsis-induced AKI patients were detected. The rat mesangial cells (RMCs) were treated with lipopolysaccharide (LPS) to induce cell injury. Then, the effects of NEAT1 suppression on the cell viability, apoptosis, cytokines expression, and oxidative stress in the LPS-stimulated RMCs were tested. The regulatory miRNA of NEAT1, as well as the target genes of this miRNA, were investigated...
April 15, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29651410/analysis-of-micrornas-expression-profiles-in-madin-darby-bovine-kidney-cells-infected-with-caprine-parainfluenza-virus-type-3
#19
Jizong Li, Li Mao, Wenliang Li, Fei Hao, Chunyan Zhong, Xing Zhu, Xinqin Ji, Leilei Yang, Wenwen Zhang, Maojun Liu, Jieyuan Jiang
Caprine parainfluenza virus type 3 (CPIV3) is a newly emerging pathogenic respiratory agent infecting both young and adult goats, and it was identified in eastern China in 2013. Cellular microRNAs (miRNAs) have been reported to be important modulators of the intricate virus-host interactions. In order to elucidate the role of miRNAs in madin-darby bovine kidney (MDBK) cells during CPIV3 infection. In this study, we performed high-throughput sequencing technology to analyze small RNA libraries in CPIV3-infected and mock-infected MDBK cells...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29625048/cell-of-origin-patterns-dominate-the-molecular-classification-of-10-000-tumors-from-33-types-of-cancer
#20
Katherine A Hoadley, Christina Yau, Toshinori Hinoue, Denise M Wolf, Alexander J Lazar, Esther Drill, Ronglai Shen, Alison M Taylor, Andrew D Cherniack, Vésteinn Thorsson, Rehan Akbani, Reanne Bowlby, Christopher K Wong, Maciej Wiznerowicz, Francisco Sanchez-Vega, A Gordon Robertson, Barbara G Schneider, Michael S Lawrence, Houtan Noushmehr, Tathiane M Malta, Joshua M Stuart, Christopher C Benz, Peter W Laird
We conducted comprehensive integrative molecular analyses of the complete set of tumors in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and representing 33 types of cancer. We performed molecular clustering using data on chromosome-arm-level aneuploidy, DNA hypermethylation, mRNA, and miRNA expression levels and reverse-phase protein arrays, of which all, except for aneuploidy, revealed clustering primarily organized by histology, tissue type, or anatomic origin. The influence of cell type was evident in DNA-methylation-based clustering, even after excluding sites with known preexisting tissue-type-specific methylation...
April 5, 2018: Cell
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