keyword
https://read.qxmd.com/read/38529479/inhibitory-effect-of-p22077-on-airway-inflammation-in-rats-with-copd-and-its-mechanism
#21
JOURNAL ARTICLE
Di Zeng, Wenbo Zhang, Xiaoju Chen, Guochun Ou, Yuewei Huang, Chengxiu Yu
PURPOSE: Here, we studied the pharmacological effect of P22077 on airway inflammation induced by lipopolysaccharide and cigarette smoke and explored the therapeutic mechanism of P22077 in COPD model RAT. PATIENTS AND METHODS: The COPD model was established by lipopolysaccharide combined with fumigation; animals were treated with vehicle or P22077. Serum, bronchoalveolar lavage fluid (BALF), and lung tissues were collected for analysis. RESULTS: Our results showed that P22077 treatment significantly improved the airway inflammation of COPD model RAT and reduced the recruitment of leukocytes in BALF, and hypersecretion of interleukin-18 (IL-18), interleukin-1β (IL-1β) in BALF and serum...
2024: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/38529362/efficacy-and-predictive-factors-of-oral-spironolactone-treatment-in-chronic-central-serous-chorioretinopathy
#22
JOURNAL ARTICLE
Sheng Gao, Yun Zhang, Meixia Zhang
PURPOSE: To evaluate the efficacy of spironolactone in the treatment of chronic central serous chorioretinopathy (CSC) and identify imaging characteristics that can predict the benefit of spironolactone treatment. METHODS: Patients with chronic CSC were treated with spironolactone (20 mg/tid) and followed for 6 months. The primary outcome measure was complete resolution of the subretinal fluid (SRF), and the best-corrected visual acuity (BCVA), the SRF area, the central macular thickness (CMT), the subfoveal choroidal thickness (SFCT), and the density of the choriocapillaris vessel and adverse events were secondary outcome measures...
2024: Journal of Ophthalmology
https://read.qxmd.com/read/38527603/contribution-of-fetal-blood-sampling-to-determining-the-prognosis-of-congenital-cytomegalovirus-infections-a-case-cohort-study-in-switzerland
#23
JOURNAL ARTICLE
Léo Pomar, Agathe Contier, Milos Stojanov, Cécile Guenot, Joanna Sichitiu, Anita C Truttmann, Yvan Vial, David Baud
BACKGROUND: Cytomegalovirus is responsible for the most common congenital infection, affecting 0.5-1% of live births in Europe. Congenital CMV infection can be diagnosed during pregnancy by viral DNA amplification in the amniotic fluid, but the prognosis of fetuses without severe brain abnormalities remains difficult to establish based on prenatal imaging alone. OBJECTIVES: To identify predictors of moderate to severe symptomatic CMV infection among fetal blood parameters, and to propose an algorithm based on these parameters and on prenatal imaging that would provide the best positive and negative predictive values...
March 23, 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38527011/natalizumab-promotes-anti-inflammatory-and-repair-effects-in-multiple-sclerosis
#24
JOURNAL ARTICLE
Ragnhild Reehorst Lereim, Petra Nytrova, Astrid Guldbrandsen, Eva Kubala Havrdova, Kjell-Morten Myhr, Harald Barsnes, Frode S Berven
BACKGROUND: Multiple sclerosis is an inflammatory and degenerative disease of the central nervous system leading to demyelination and axonal loss. Relapsing-remitting multiple sclerosis (RRMS) is commonly treated by anti-inflammatory drugs, where one of the most effective drugs to date is the monoclonal antibody natalizumab. METHODS: The cerebrospinal fluid (CSF) proteome was analyzed in 56 patients with RRMS before and after natalizumab treatment, using label-free mass spectrometry and a subset of the changed proteins were verified by parallel reaction monitoring in a new cohort of 20 patients, confirming the majority of observed changes...
2024: PloS One
https://read.qxmd.com/read/38526139/diammonium-glycyrrhizinate-inhibited-inflammatory-response-and-modulated-serum-metabolism-in-poly-i-c-induced-pneumonia-model-mice
#25
JOURNAL ARTICLE
Yan Meng, Xuanlin Cai, Shan Cong, Jiao Sun, Wenjing Du, Xiumin Ma, Huantian Cui, Li Luo, Li Wang
Currently, the coronavirus disease 2019 (COVID-19) is becoming a serious threat to human health worldwide. Therefore, there is a great need to develop effective drugs against viral pneumonia. Diammonium glycyrrhizinate (DG), derived from Glycyrrhiza glabra L., has been demonstrated with significant anti-inflammatory properties. However, the therapeutic effects and mechanisms of DG on pneumonia require further clarification. In this study, mice received intratracheal injection of polyinosinic-polycytidylic acid (poly(I:C)) to induce pneumonia and were treated with DG...
March 25, 2024: Shock
https://read.qxmd.com/read/38525737/circulating-mirnas-as-novel-clinical-biomarkers-in-temporal-lobe-epilepsy
#26
REVIEW
Lorenza Guarnieri, Nicola Amodio, Francesca Bosco, Sara Carpi, Martina Tallarico, Luca Gallelli, Vincenzo Rania, Rita Citraro, Antonio Leo, Giovambattista De Sarro
Temporal lobe epilepsy (TLE) represents the most common form of refractory focal epilepsy. The identification of innovative clinical biomarkers capable of categorizing patients with TLE, allowing for improved treatment and outcomes, still represents an unmet need. Circulating microRNAs (c-miRNAs) are short non-coding RNAs detectable in body fluids, which play crucial roles in the regulation of gene expression. Their characteristics, including extracellular stability, detectability through non-invasive methods, and responsiveness to pathological changes and/or therapeutic interventions, make them promising candidate biomarkers in various disease settings...
March 17, 2024: Non-Coding RNA
https://read.qxmd.com/read/38525233/cytokine-secretion-in-stem-cells-of-cattle-infected-with-bovine-leukaemia-virus
#27
JOURNAL ARTICLE
Maria Szczotka, Jacek Kuźmak
INTRODUCTION: Bovine leukaemia virus (BLV) is a Deltaretrovirus responsible for enzootic bovine leukosis, the most common neoplastic disease of cattle. It deregulates the immune system, favouring secondary infections and changes in the blood and lymphatic tissues. Blood homeostasis depends on functional haematopoietic stem cells (HSCs). Bone marrow is populated by these cells, which express CD34+ and CD35+ surface antigens and produce and release cytokines involved in the maintenance of haematopoiesis...
March 2024: Journal of Veterinary Research
https://read.qxmd.com/read/38525136/pulmonary-toxicity-assessment-of-polypropylene-polystyrene-and-polyethylene-microplastic-fragments-in-mice
#28
JOURNAL ARTICLE
Isaac Kwabena Danso, Jong-Hwan Woo, Seung Hoon Baek, Kilsoo Kim, Kyuhong Lee
UNLABELLED: Polypropylene (PP), polystyrene (PS), and polyethylene (PE) plastics are commonly used in household items such as electronic housings, food packaging, bottles, bags, toys, and roofing membranes. The presence of inhalable microplastics in indoor air has become a topic of concern as many people spent extended periods of time indoors during the COVID-19 pandemic lockdown restrictions, however, the toxic effects on the respiratory system are not properly understood. We examined the toxicity of PP, PS, and PE microplastic fragments in the pulmonary system of C57BL/6 mice...
April 2024: Toxicological Research
https://read.qxmd.com/read/38524642/durvalumab-plus-carboplatin-etoposide-treatment-in-a-patient-with-small-cell-lung-cancer-on-hemodialysis-a-case-report-and-literature-review
#29
JOURNAL ARTICLE
Futoshi Ushijima, Tetsunari Hase, Yuki Yamashita, Hangsoo Kim, Tomoya Shimokata, Chiaki Kondo, Tomonori Sato, Tomoya Baba, Shohei Watanabe, Keisuke Futamura, Yuichi Ando, Masashi Mizuno, Makoto Ishii
Little is known about the efficacy and safety of durvalumab plus carboplatin-etoposide treatment in patients with extensive-disease (ED) small-cell lung cancer (SCLC) on hemodialysis. Here, we present a case of a 67-year-old man with pleuroperitoneal communication on continuous ambulatory peritoneal dialysis who was diagnosed with ED-SCLC based on a cytological analysis of the peritoneal fluid. He was switched from peritoneal dialysis to hemodialysis and received durvalumab (1500 mg/body on day 1) plus carboplatin (area under the concentration-time curve = 5, 125 mg on day 1) and etoposide (50 mg/m2 on days 1 and 3) as first-line therapy...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38524135/biomarkers-and-computational-models-for-predicting-efficacy-to-tumor-ici-immunotherapy
#30
REVIEW
Yurong Qin, Miaozhe Huo, Xingwu Liu, Shuai Cheng Li
Numerous studies have shown that immune checkpoint inhibitor (ICI) immunotherapy has great potential as a cancer treatment, leading to significant clinical improvements in numerous cases. However, it benefits a minority of patients, underscoring the importance of discovering reliable biomarkers that can be used to screen for potential beneficiaries and ultimately reduce the risk of overtreatment. Our comprehensive review focuses on the latest advancements in predictive biomarkers for ICI therapy, particularly emphasizing those that enhance the efficacy of programmed cell death protein 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) inhibitors and cytotoxic T-lymphocyte antigen-4 (CTLA-4) inhibitors immunotherapies...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38523682/csf-findings-in-chinese-patients-with-nmdar-lgi1-and-gababr-antibody-associated-encephalitis
#31
JOURNAL ARTICLE
Shan Qiao, Haiyun Li, Caisan Cui, Chong Zhang, Aihua Wang, Wenjing Jiang, Shanchao Zhang
PURPOSE: CSF inflammation in subtypes of antibody-defined autoimmune encephalitis (AE) ranges in intensity from moderate to severe. In a retrospective, cross-sectional study, we characterized CSF findings in Chinese patients with anti-N-methyl-D-aspartate receptor encephalitis (NMDAR-E), anti-leucine-rich glioma-inactivated 1 encephalitis (LGI1-E), and anti-gamma aminobutyric acid-B receptor encephalitis (GABABR-E). PATIENTS AND METHODS: The AE cases, including 102 NMDAR-E, 68 LGI1-E and 15 GABABR-E, were included...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38523058/hormone-replacement-therapy-and-periodontitis-progression-in-postmenopausal-women-a-prospective-cohort-study
#32
JOURNAL ARTICLE
Ying Man, Cui Zhang, Cheng Cheng, Laiqi Yan, Min Zong, Feifei Niu
OBJECTIVE: This study aimed to investigate the responses of periodontal environment to hormone replacement therapy (HRT) in postmenopausal women with or without periodontitis. BACKGROUND: HRT is a common and effective strategy for controlling menopausal symptoms, while the changes of periodontal environment under it, particularly in postmenopausal women with periodontitis, remain unclear. METHODS: As a prospective cohort study, a total of 97 postmenopausal women receiving HRT were screened, including 47 with and 50 without periodontitis...
March 24, 2024: Journal of Periodontal Research
https://read.qxmd.com/read/38522489/numerical-study-of-drop-dynamics-for-inkjet-based-3d-printing-of-pharmaceutical-tablets
#33
JOURNAL ARTICLE
Tanu Mehta, Hossain Aziz, Koyel Sen, Venkatraman Nagarajan, Anson W K Ma, Bodhisattwa Chaudhuri
Interest in 3D printing has been growing rapidly especially in pharmaceutical industry due to its multiple advantages such as manufacturing versatility, personalization of medicine, scalability, and cost effectiveness. Inkjet based 3D printing gained special attention after FDA's approval of Spritam® manufactured by Aprecia pharmaceuticals in 2015. The precision and printing efficiency of 3D printing is strongly influenced by the dynamics of ink/binder jetting, which further depends on the ink's fluid properties...
March 22, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38520923/towards-optimal-design-of-patient-isolation-units-in-emergency-rooms-to-prevent-airborne-virus-transmission-from-computational-fluid-dynamics-to-data-driven-modeling
#34
JOURNAL ARTICLE
Jong Hyeon Lee, Jae Woo Shim, Min Hyuk Lim, Changhoon Baek, Byoungjun Jeon, Minwoo Cho, Sungwoo Park, Dong Hyun Choi, Byeong Soo Kim, Dan Yoon, Young Gyun Kim, Seung Yeon Cho, Kyung-Min Lee, Myoung-Souk Yeo, Hangman Zo, Sang Do Shin, Sungwan Kim
BACKGROUND: Patient isolation units (PIUs) can be an effective method for effective infection control. Computational fluid dynamics (CFD) is commonly used for PIU design; however, optimizing this design requires extensive computational resources. Our study aims to provide data-driven models to determine the PIU settings, thereby promoting a more rapid design process. METHOD: Using CFD simulations, we evaluated various PIU parameters and room conditions to assess the impact of PIU installation on ventilation and isolation...
March 16, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38520402/pacemaking-in-the-lymphatic-system
#35
JOURNAL ARTICLE
Michael J Davis, Scott D Zawieja
Lymphatic collecting vessels exhibit spontaneous phasic contractions that are critical for lymph propulsion and tissue fluid homeostasis. This rhythmic activity is driven by action potentials conducted across the lymphatic muscle cell (LMC) layer to produce entrained contractions. The contraction frequency of a lymphatic collecting vessel displays exquisite mechanosensitivity, with a dynamic range from <1 to >20 contractions per minute. A myogenic pacemaker mechanism intrinsic to the LMCs was initially postulated to account for pressure-dependent chronotropy...
March 23, 2024: Journal of Physiology
https://read.qxmd.com/read/38520031/antibacterial-activity-of-the-antimicrobial-peptide-pmap-36-in-combination-with-tetracycline-against-porcine-extraintestinal-pathogenic-escherichia-coli-in-vitro-and-in-vivo
#36
JOURNAL ARTICLE
Qi Tao, Yi Lu, Qian Liu, Runqiu Chen, Yating Xu, Gang Li, Xiaoxiang Hu, Chao Ye, Lianci Peng, Rendong Fang
The increase in the emergence of antimicrobial resistance has led to great challenges in controlling porcine extraintestinal pathogenic Escherichia coli (ExPEC) infections. Combinations of antimicrobial peptides (AMPs) and antibiotics can synergistically improve antimicrobial efficacy and reduce bacterial resistance. In this study, we investigated the antibacterial activity of porcine myeloid antimicrobial peptide 36 (PMAP-36) in combination with tetracycline against porcine ExPEC PCN033 both in vitro and in vivo...
March 22, 2024: Veterinary Research
https://read.qxmd.com/read/38519033/survival-and-expression-of-rpos-and-grxb-of-cronobacter-sakazakii-in-powdered-infant-formula-under-simulated-gastric-conditions-of-newborns
#37
JOURNAL ARTICLE
Devita Kireina, Valeria R Parreira, Lawrence Goodridge, Jeffrey M Farber
Cronobacter sakazakii can cause severe illnesses in infants, predominantly in preterm newborns, with consumption of contaminated powdered infant formula (PIF) being the major vehicle of infection. Using a dynamic human gastrointestinal simulator called the SHIME, this study examined the effects of gastric acidity and gastric digestion time of newborns on the survival and expression of stress genes of C. sakazakii. Individual strains, inoculated at 7 log CFU/mL into reconstituted PIF, were exposed to gastric pH values of 4...
March 20, 2024: Journal of Food Protection
https://read.qxmd.com/read/38518684/non-tuberculous-mycobacterial-isolates-from-panama-a-retrospective-5-year-analysis-2017-2021
#38
JOURNAL ARTICLE
Prudencio González, Juan Domínguez, Pedro Del Cid, Samantha Rosas, Ariel Magallón-Tejada
BACKGROUND: The genus Mycobacterium includes well-known bacteria such as M. tuberculosis causing tuberculosis and M. leprae causing leprosy. Additionally, various species collectively termed non-tuberculous mycobacteria (NTM) can cause infections in humans and animals, affecting individuals across all age groups and health conditions. However, information on NTM infection prevalence in Panama is limited. METHODS: This study conducted a retrospective analysis of clinical records from 2017 to 2021, specifically focusing on patients with NTM isolates...
March 5, 2024: Journal of Infection and Public Health
https://read.qxmd.com/read/38517856/endoplasmic-reticulum-stress-drives-macrophages-to-produce-il-33-to-favor-th2-polarization-in-the-airways
#39
JOURNAL ARTICLE
Yuan Xiao, Huangping Zhang, Yu Liu, Lihua Mo, Yun Liao, Qinmiao Huang, Liteng Yang, Caijie Zhou, Jiangqi Liu, Xizhuo Sun, Haiqiong Yu, Pingchang Yang
Interleukin (IL)-33 is a key driver of T helper 2 (Th2) cell polarization. Endoplasmic reticulum (ER) stress plays a role in the skewed T cell activation. The objective of this project is to elucidate the role of IL-33 derived from macrophages in inducing Th2 polarization in the airways. In this study, bronchoalveolar lavage fluids (BALF) were collected from patients with asthma and healthy control subjects. Macrophages were isolated from the BALF by flow cytometry cell sorting. An asthmatic mouse model was established using the ovalbumin/alum protocol...
March 22, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38517820/effect-of-orthodontics-combined-with-fibre-reinforced-composite-resin-bonded-fixed-partial-denture-on-anterior-dentition-defects-with-minimal-vertical-intermaxillary-space
#40
JOURNAL ARTICLE
Shi-Lei Han, Na Li
BACKGROUND: Prosthodontics are often performed to treat patients with malocclusion and dentition defects. However, single prosthodontics cannot properly correct the disharmony of teeth, dental arch and other parts affected by malocclusion, and some patients may have difficulty in recovering the occlusal function due to poor prosthodontics. OBJECTIVE: This study aims to investigate the effect of orthodontics combined with fibre-reinforced composite resin-bonded fixed partial denture (FRC-RBFPD) on anterior dentition defects with minimal vertical intermaxillary space...
February 29, 2024: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
keyword
keyword
110684
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.