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https://www.readbyqxmd.com/read/29928919/the-psychoactive-substance-of-cannabis-%C3%AE-9-tetrahydrocannabinol-thc-negatively-regulates-cftr-in-airway-cells
#1
Sheng-Wei Chang, Jack Wellmerling, Xiaoli Zhang, Rachael E Rayner, Wissam Osman, Sara Mertz, Amal O Amer, Mark E Peeples, Prosper N Boyaka, Estelle Cormet-Boyaka
BACKGROUND: Marijuana consumption is on the rise in the US but the health benefits of cannabis smoking are controversial and the impact of cannabis components on lung homeostasis is not well-understood. Lung function requires a fine regulation of the ion channel CFTR, which is responsible for fluid homeostasis and mucocilliary clearance. The goal of this study was to assess the effect that exposure to Δ9-tetrahydrocannabinol (THC), the psychoactive substance present in marijuana, has on CFTR expression and function...
June 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29928682/integration-of-sensors-in-gastrointestinal-organoid-culture-for-biological-analysis
#2
REVIEW
Ge-Ah Kim, Nicholas J Ginga, Shuichi Takayama
The gastrointestinal (GI) tract regulates physiologic responses in complex ways beyond facilitating nutrient entry into the circulatory system. Because of the anatomic location of the GI tract, studying in vivo physiology of the human gut, including host cell interaction with the microbiota, is limited. GI organoids derived from human stem cells are gaining interest as they recapitulate in vivo cellular phenotypes and functions. An underdeveloped capability that would further enhance the utility of these miniature models of the GI tract is to use sensors to quantitatively characterize the organoid systems with high spatiotemporal resolution...
2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29927776/critical-care-management-of-anti-n-methyl-d-asparate-receptor-encephalitis
#3
Ron R Neyens, George E Gaskill, Julio A Chalela
OBJECTIVES: Anti-N-methyl-D-asparate receptor encephalitis is considered an immune-mediated form of encephalitis with paraneoplastic and nonparaneoplastic forms. Delay in recognition is common and patients typically present to the ICU without a diagnosis or with complications following a delayed diagnosis. The aim of this review is to provide a focused overview for the ICU clinician regarding presentation, diagnosis, and critical care management. DATA SOURCES, STUDY SELECTION, AND DATA EXTRACTION: PubMed database search with manual review of articles involving anti-N-methyl-D-asparate receptor encephalitis...
June 20, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29926273/gut-immunoglobulin-alpha-anti-glycan-binding-profiles-as-a-research-tool-for-local-disease-detection
#4
Joseph J Otto, Crystal L Daniels, Lindsay N Schambeau, Brittany N Williams, Jana M Rocker, Lewis K Pannell
A promising approach capitalizing on the specific and highly sensitive characteristics of the body's own immune system is demonstrated in the context of revealing pancreatic ductal adenocarcinoma cancer (PDAC). IgA from a local biofluid called gastrointestinal lavage fluid (GLF) is used to investigate glycan reactivity to show the potential of this approach. IgA antibody responses, just as with IgG, result in amplification of a small signal which aids in detecting changes from a healthy state. IgA from GLF was screened against glycan arrays containing 609 glycan structures to investigate differential binding patterns associated with the disease...
June 2018: Glycoconjugate Journal
https://www.readbyqxmd.com/read/29926230/estimating-mean-circulatory-filling-pressure-in-clinical-practice-a-systematic-review-comparing-three-bedside-methods-in-the-critically-ill
#5
REVIEW
Marije Wijnberge, Daniko P Sindhunata, Michael R Pinsky, Alexander P Vlaar, Else Ouweneel, Jos R Jansen, Denise P Veelo, Bart F Geerts
The bedside hemodynamic assessment of the critically ill remains challenging since blood volume, arterial-venous interaction and compliance are not measured directly. Mean circulatory filling pressure (Pmcf ) is the blood pressure throughout the vascular system at zero flow. Animal studies have shown Pmcf provides information on vascular compliance, volume responsiveness and enables the calculation of stressed volume. It is now possible to measure Pmcf at the bedside. We performed a systematic review of the current Pmcf measurement techniques and compared their clinical applicability, precision, accuracy and limitations...
June 20, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29926195/performance-evaluation-of-a-robot-assisted-catheter-operating-system-with-haptic-feedback
#6
Yu Song, Shuxiang Guo, Xuanchun Yin, Linshuai Zhang, Hideyuki Hirata, Hidenori Ishihara, Takashi Tamiya
In this paper, a novel robot-assisted catheter operating system (RCOS) has been proposed as a method to reduce physical stress and X-ray exposure time to physicians during endovascular procedures. The unique design of this system allows the physician to apply conventional bedside catheterization skills (advance, retreat and rotate) to an input catheter, which is placed at the master side to control another patient catheter placed at the slave side. For this purpose, a magnetorheological (MR) fluids-based master haptic interface has been developed to measure the axial and radial motions of an input catheter, as well as to provide the haptic feedback to the physician during the operation...
June 20, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29925814/antioxidant-peptides-from-goat-milk-fermented-by-lactobacillus-casei-l61-preparation-optimization-and-stability-evaluation-in-simulated-gastrointestinal-fluid
#7
Guowei Shu, Xiaoyu Shi, Li Chen, Jianbo Kou, Jiangpeng Meng, He Chen
Antioxidant peptides are currently the focus of many studies, since they eliminate free radicals in the human body without harmful effects. In the present study, Lactobacillus casei L61 was used as a starter culture to ferment goat milk because of its high capacity to produce antioxidant peptides. An optimal nutrients formula (casein, casein peptone, glucose, soybean peptone, inulin, calcium lactate, and cysteine) was investigated by Plackett⁻Burman (P⁻B) and Box⁻Behnken (B⁻B) designs for response surface methodology (RSM)...
June 20, 2018: Nutrients
https://www.readbyqxmd.com/read/29925386/the-transcription-factor-crem-drives-an-inflammatory-phenotype-of-t-cells-in-oligoarticular-juvenile-idiopathic-arthritis
#8
Kim Ohl, Helge Nickel, Halima Moncrieffe, Patricia Klemm, Anja Scheufen, Dirk Föll, Viktor Wixler, Angela Schippers, Norbert Wagner, Lucy R Wedderburn, Klaus Tenbrock
BACKGROUND: Inflammatory effector T cells trigger inflammation despite increased numbers of Treg cells in the synovial joint of patients suffering from juvenile idiopathic arthritis (JIA). The cAMP response element (CREM)α is known to play a major role in regulation of T cells in SLE, colitis, and EAE. However, its role in regulation of effector T cells within the inflammatory joint is unknown. METHODS: CREM expression was analyzed in synovial fluid cells from oligoarticular JIA patients by flow cytometry...
June 20, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29925237/peripheral-protein-unfolding-drives-membrane-bending
#9
Hew Ming Helen Siaw, Gokul Raghunath, R Brian Dyer
Dynamic modulation of lipid membrane curvature can be achieved by a number of peripheral protein binding mechanisms such as hy-drophobic insertion of amphipathic helices and membrane scaffolding. Recently, an alternative mechanism was proposed in which crowding of peripherally bound proteins induces membrane curvature through steric pressure generated by lateral collisions. This effect was enhanced using intrinsically disordered proteins that possess high hydrodynamic radii, prompting us to explore whether membrane bending can be triggered by the folding-unfolding transition of surface-bound proteins...
June 20, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29925126/-preliminary-study-of-the-arm-equilibrium-pressure-to-predict-the-effect-of-fluid-challenge-on-urine-output-in-oliguric-intensive-care-unit-patients
#10
Z Y Xie, Z Y Zhang, Y Zhu, Z Wang
Objective: To evaluate whether arm equilibrium pressure (Parm) is helpful to predict the effect of fluid load in improving oliguria in intensive care unit(ICU) patients. Methods: Hemodynamically stable patients [mean artery pressure (MAP)>65 mmHg (1 mmHg=0.133 kPa), heart rate (HR)<120 beats/min, lactic acid<2 mmol/L] with urine output (UO)<0.5 ml·kg(-1)·h(-1) for 3 consecutive hours were enrolled. The fluid loading was performed by infusion of ringer's lactate 500 ml within 30 minute after baseline hemodynamic data were recorded...
June 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29924630/in-search-of-the-spherical-femoroplasty-cam-overresection-leads-to-inferior-functional-scores-before-and-after-revision-hip-arthroscopic-surgery
#11
Yosif Mansor, Itay Perets, Mary R Close, Brian H Mu, Benjamin G Domb
BACKGROUND: Femoroplasty performed for the treatment of cam-type femoroacetabular impingement (FAI) has become a common procedure. Underresection may result in residual FAI. Conversely, overresection may disrupt the labral seal, which is responsible for chondroprotective fluid dynamics of the hip. Hypothesis/Purpose: It was hypothesized that cam overresection negatively affects hip function. The purpose was to examine the effect of the accuracy of previous femoroplasty on hips presenting for revision hip arthroscopic surgery...
June 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29923969/clinical-symptoms-laboratory-and-microbial-patterns-of-suspected-neonatal-sepsis-cases-in-a-children-s-referral-hospital-in-northwestern-iran
#12
Majid Mahallei, Mohammad Ahangarzadeh Rezaee, Bahareh Mehramuz, Shayan Beheshtirooy, Babak Abdinia
Sepsis is the systemic response to infection manifested as hyperthermia or hypothermia, tachycardia, tachypnea, and shock. This condition represents a major life-threatening factor in all age groups, particularly in neonatal period. The present study aimed to examine the results of blood, cerebrospinal fluid (CSF), and urine culture tests in suspected neonatal sepsis cases in northwestern Iran.This descriptive-analytical study was conducted on suspected neonatal sepsis cases hospitalized in Tabriz Children's Hospital...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923422/anti-inflammatory-and-anti-fibrotic-treatment-in-a-rodent-model-of-acute-lung-injury-induced-by-sulfur-dioxide
#13
Elisabeth Wigenstam, Linda Elfsmark, Lina Ågren, Christine Akfur, Anders Bucht, Sofia Jonasson
CONTEXT: Inhalation of sulfur dioxide (SO2 ) affects the lungs and exposure to high concentrations can be lethal. The early pulmonary response after inhaled SO2 involves tissue injury, acute neutrophilic lung inflammation and airway hyperresponsiveness (AHR). In rats, long-term pulmonary fibrosis is evident 14 days post-exposure as indicated by analysis of collagen deposition in lung tissue. Early treatment with a single dose of dexamethasone (DEX,10 mg/kg) significantly attenuates the acute inflammatory response in airways...
June 20, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29922678/stem-cell-cytoskeletal-responses-to-pulsatile-flow-in-heart-valve-tissue-engineering-studies
#14
Glenda Castellanos, Sana Nasim, Denise M Almora, Sasmita Rath, Sharan Ramaswamy
Heart valve replacement options remain exceedingly limited for pediatric patients because they cannot accommodate somatic growth. To overcome this shortcoming, heart valve tissue engineering using human bone marrow stem cells (HBMSCs) has been considered a potential solution to the treatment of critical congenital valvular defects. The mechanical environments during in vitro culture are key regulators of progenitor cell fate. Here, we report on alterations in HBMSCs, specifically in their actin cytoskeleton and their nucleus under fluid-induced shear stresses of relevance to heart valves...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29922273/neutrophil-elastase-subverts-the-immune-response-by-cleaving-toll-like-receptors-and-cytokines-in-pneumococcal-pneumonia
#15
Hisanori Domon, Kosuke Nagai, Tomoki Maekawa, Masataka Oda, Daisuke Yonezawa, Wataru Takeda, Takumi Hiyoshi, Hikaru Tamura, Masaya Yamaguchi, Shigetada Kawabata, Yutaka Terao
Excessive activation of neutrophils results in the release of neutrophil elastase (NE), which leads to lung injury in severe pneumonia. Previously, we demonstrated a novel immune subversion mechanism involving microbial exploitation of this NE ability, which eventually promotes disruption of the pulmonary epithelial barrier. In the present study, we investigated the effect of NE on host innate immune response. THP-1-derived macrophages were stimulated with heat-killed Streptococcus pneumoniae or lipopolysaccharide in the presence or absence of NE followed by analysis of toll-like receptor (TLR) and cytokine expression...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29922258/serological-and-pathogenic-analyses-of-fowl-adenovirus-serotype-4-fadv-4-strain-in-muscovy-ducks
#16
Xianglong Yu, Zhenzhong Wang, Hao Chen, Xiaoyu Niu, Yanguo Dou, Jing Yang, Yi Tang, Youxiang Diao
Hydropericardium hepatitis syndrome (HHS) is a lethal disease caused by Fowl adenovirus serotype 4(FAdV-4) that mainly infects 3- to 6-week-old broiler chicks. In 2015, an infectious disease characterized similar symptom to HHS in broilers outbroke in commercial duck flocks in Shandong province. FAdV-4 was isolated from naturally infected ducks and determined by polymerase chain reaction (PCR) amplification and DNA sequence analysis. In order to investigate the effect of FAdV-4 infection on muscovy ducks, we determined and characterized the FAdV-4 Isolate, and assessed its pathogenicity...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29922241/primary-human-microglia-are-phagocytically-active-and-respond-to-borrelia-burgdorferi-with-upregulation-of-chemokines-and-cytokines
#17
Jacob R Greenmyer, Robert A Gaultney, Catherine A Brissette, John A Watt
The Lyme disease causing bacterium Borrelia burgdorferi has an affinity for the central nervous system (CNS) and has been isolated from human cerebral spinal fluid by 18 days following Ixodes scapularis tick bite. Signaling from resident immune cells of the CNS could enhance CNS penetration by B. burgdorferi and activated immune cells through the blood brain barrier resulting in multiple neurological complications, collectively termed neuroborreliosis. The ensuing symptoms of neurological impairment likely arise from a glial-driven, host inflammatory response to B...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29922162/multi-walled-carbon-nanotubes-augment-allergic-airway-eosinophilic-inflammation-by-promoting-cysteinyl-leukotriene-production
#18
Sophia Carvalho, Maria Ferrini, Lou Herritt, Andrij Holian, Zeina Jaffar, Kevan Roberts
Multi-walled carbon nanotubes (MWCNT) have been reported to promote lung inflammation and fibrosis. The commercial demand for nanoparticle-based materials has expanded rapidly and as demand for nanomaterials grows, so does the urgency of establishing an appreciation of the degree of health risk associated with their increased production and exposure. In this study, we examined whether MWCNT inhalation elicited pulmonary eosinophilic inflammation and influenced the development of allergic airway inflammatory responses...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29922085/the-effect-of-passive-leg-raising-maneuver-on-hemodynamic-stability-during-anesthesia-induction-for-adult-cardiac-surgery
#19
Solmaz Fakhari, Eissa Bilehjani, Haleh Farzin, Hojjat Pourfathi, Mohsen Chalabianlou
Introduction: Some cardiac patients do not tolerate the intravenous fluid load commonly administered before anesthesia induction. This study investigated preinduction passive leg-raising maneuver (PLRM) as an alternative method to fluid loading before cardiac anesthesia. Methods and materials: During a 6-month period, 120 adult elective heart surgery patients were enrolled in this study and allocated into 2 groups: PLRM group vs control group (n=60). Anesthesia was induced using midazolam, fentanyl, and cisatracurium...
2018: Integrated Blood Pressure Control
https://www.readbyqxmd.com/read/29921975/viscoelastic-optical-nonlocality-of-low-loss-epsilon-near-zero-nanofilms
#20
Domenico de Ceglia, Michael Scalora, Maria A Vincenti, Salvatore Campione, Kyle Kelley, Evan L Runnerstrom, Jon-Paul Maria, Gordon A Keeler, Ting S Luk
Optical nonlocalities are elusive and hardly observable in traditional plasmonic materials like noble and alkali metals. Here we report experimental observation of viscoelastic nonlocalities in the infrared optical response of epsilon-near-zero nanofilms made of low-loss doped cadmium-oxide. The nonlocality is detectable thanks to the low damping rate of conduction electrons and the virtual absence of interband transitions at infrared wavelengths. We describe the motion of conduction electrons using a hydrodynamic model for a viscoelastic fluid, and find excellent agreement with experimental results...
June 19, 2018: Scientific Reports
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