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https://www.readbyqxmd.com/read/28721028/frailty-in-community-dwelling-older-adults-association-with-adverse-outcomes
#1
Sergio Sánchez-García, Carmen García-Peña, Antoni Salvà, Rosalinda Sánchez-Arenas, Víctor Granados-García, Juan Cuadros-Moreno, Laura Bárbara Velázquez-Olmedo, Ángel Cárdenas-Bahena
BACKGROUND: The study of frailty is important to identify the additional needs of medical long-term care and prevent adverse outcomes in community dwelling older adults. This study aimed to determine the prevalence of frailty and its association with adverse outcomes in community dwelling older adults. METHODS: A cross-sectional study was carried out from April to September 2014. The population sample was 1,252 older adults (≥60 years) who were beneficiaries of the Mexican Institute of Social Security (IMSS) in Mexico City...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28721027/frequency-of-frailty-and-its-association-with-cognitive-status-and-survival-in-older-chileans
#2
Cecilia Albala, Lydia Lera, Hugo Sanchez, Barbara Angel, Carlos Márquez, Patricia Arroyo, Patricio Fuentes
BACKGROUND: Age-associated brain physiologic decline and reduced mobility are key elements of increased age-associated vulnerability. OBJECTIVE: To study the frequency of frailty phenotype and its association with mental health and survival in older Chileans. METHODS: Follow-up of ALEXANDROS cohorts designed to study disability associated with obesity in community-dwelling people 60 years and older living in Santiago, Chile. At baseline, 2,098 (67% women) of 2,372 participants were identified as having the frailty phenotype: weak handgrip dynamometry, unintentional weight loss, fatigue/exhaustion, five chair-stands/slow walking speed and difficulty walking (low physical activity)...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28710665/physical-exercise-reduces-pyruvate-carboxylase-pcb-and-contributes-to-hyperglycemia-reduction-in-obese-mice
#3
Vitor Rosetto Muñoz, Rafael Calais Gaspar, Barbara Moreira Crisol, Guilherme Pedron Formigari, Marcella Ramos Sant'Ana, José Diego Botezelli, Rodrigo Stellzer Gaspar, Adelino S R da Silva, Dennys Esper Cintra, Leandro Pereira de Moura, Eduardo Rochete Ropelle, José Rodrigo Pauli
The present study evaluated the effects of exercise training on pyruvate carboxylase protein (PCB) levels in hepatic tissue and glucose homeostasis control in obese mice. Swiss mice were distributed into three groups: control mice (CTL), fed a standard rodent chow; diet-induced obesity (DIO), fed an obesity-inducing diet; and a third group, which also received an obesity-inducing diet, but was subjected to an exercise training protocol (DIO + EXE). Protocol training was carried out for 1 h/d, 5 d/wk, for 8 weeks, performed at an intensity of 60% of exhaustion velocity...
July 14, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28679623/high-but-not-low-exercise-volume-shifts-the-balance-of-renin-angiotensin-system-towards-ace2-mas-receptor-axis-in-skeletal-muscle-in-obese-rats
#4
Eliete Dalla Corte Frantz, Isabele Gomes Giori, Marcus Vinícius Machado, D'Angelo Carlo Magliano, Fernanda Marques Freitas, Mariana Sodré Boêta Andrade, Aline Bomfim Vieira, Antonio Claudio Lucas Claudio Lucas da Nóbrega, Eduardo Tibirica
Metabolic Syndrome (MS) is a cluster of metabolic risk factors which is linked to central obesity, elevated blood pressure, insulin resistance (IR) and dyslipidemia, where the rennin-angiotensin system (RAS) may provide a link among them. This study aimed to evaluate volume exercise effects comparing low versus high volume of chronic aerobic exercise on RAS axes in skeletal muscle in a diet-induced obesity (DIO) rat model. For this, male Wistar-Kyoto rats were fed a standard chow diet (SC) or a high-fat diet (HF) for 32 weeks...
July 5, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28667436/comparison-of-quality-of-life-among-community-dwelling-older-adults-with-the-frailty-phenotype
#5
Sergio Sánchez-García, Katia Gallegos-Carrillo, María Claudia Espinel-Bermudez, Svetlana V Doubova, Rosalinda Sánchez-Arenas, Carmen García-Peña, Antoni Salvà, Silvia C Briseño-Fabian
PURPOSE: To compare the perception of the quality of life (QOL) of community-dwelling older adults with the phenotype of frailty. METHODS: Cross-sectional analysis of baseline data of the "Cohort of Obesity, Sarcopenia and Frailty of Mexican Older Adults" (COSFOMA). Operationalization of frailty was carried out using the phenotype as follows: weight loss, self-report of exhaustion, low physical activity, slow gait, and weakness. QOL was measured using two scales: World Health Organization Quality of Life of Older Adults (WHOQOL-OLD), which is a specific instrument for the elderly population, and Short Form-36 Health Survey (SF-36), a generic instrument to evaluate the QOL related to health...
June 30, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28634968/adapting-the-chester-step-test-to-predict-peak-oxygen-uptake-in-children
#6
Albane Bertha Rosa Maggio, Philippe Vuistiner, Antoinette Crettenand, René Tabin, Xavier Eric Martin, Maurice Beghetti, Nathalie Jacqueline Farpour-Lambert, Olivier Deriaz
AIM OF THE STUDY: Maximal exercise testing may be difficult to perform in clinical practice, especially in obese children who have low cardiorespiratory fitness and exercise tolerance. We aimed to elaborate a model predicting peak oxygen consumption (VO2) in lean and obese children with use of the submaximal Chester step test. METHODS: We performed a maximal step test, which consisted of 2-minute stages with increasing intensity to exhaustion, in 169 lean and obese children (age range: 7-16 years)...
June 21, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28625227/a-brief-review-of-salient-factors-influencing-adult-eating-behaviour
#7
Christine Emilien, James H Hollis
A better understanding of the factors that influence eating behaviour is of importance as our food choices are associated with the risk of developing chronic diseases such as obesity, CVD, type 2 diabetes or some forms of cancer. In addition, accumulating evidence suggests that the industrial food production system is a major contributor to greenhouse gas emission and may be unsustainable. Therefore, our food choices may also contribute to climate change. By identifying the factors that influence eating behaviour new interventions may be developed, at the individual or population level, to modify eating behaviour and contribute to society's health and environmental goals...
June 19, 2017: Nutrition Research Reviews
https://www.readbyqxmd.com/read/28602121/frailty-and-risk-of-cardiovascular-diseases-in-older-persons-the-age-gene-environment-susceptibility-reykjavik-study
#8
Nicola Veronese, Kristin Sigeirsdottir, Gudny Eiriksdottir, Elisa Marques, Didier Chalhoub, Caroline Phillips, Lenore Launer, Stefania Maggi, Vilmundur Gudnason, Tamara B Harris
Frailty is a risk factor for cardiovascular diseases (CVD), but the studies available have not considered the presence of sub-clinical atherosclerotic disease as potential confounders. We investigated the association between frailty and the onset of CVD independently of sub-clinical atherosclerotic disease. For this reason, a sample of 3818 older participants participating in the Age, Gene/Environment SusceptibilityReykjavik Study (AGESReykjavik) without CVD at baseline was followed for a median of 8...
June 10, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28599692/early-detection-of-chronic-obstructive-pulmonary-disease-in-apparently-healthy-attendants-of-tertiary-care-hospital-and-assessment-of-its-severity
#9
Tahira Zubair, Amanullah Abbassi, Osama Ahsan Khan
OBJECTIVE: Early detection of Chronic Obstructive Pulmonary Disease in apparently healthy attendants of tertiary care hospital and assessment of its severity. STUDY DESIGN: Cross-sectional, observational study. PLACE AND DURATION OF STUDY: Study was conducted from January 2015 to July 2015 at Dow University Hospital, Ojha campus. METHODOLOGY: Ascreening method was designed for apparently healthy individuals including attendants of patients, hospital staff, faculty and students, belonging to age group 18-60 years after excluding severe obesity and already diagnosed respiratory and cardiovascular diseases by means of history...
May 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28594107/mirnas-in-nutrition-obesity-and-cancer-the-biology-of-mirnas-in-metabolic-disorders-and-its-relationship-with-cancer-development
#10
Verónica Del Carmen Martínez-Jiménez, Alejandro Méndez-Mancilla, Diana Patricia Portales-Pérez
SCOPE: The scope of this review is to explain how metabolic disorders originated by a deficient nutrition can develop into a neoplasic process by the alteration of epigenetic mechanisms like miRNAs. Obesity is a proinflammatory state with a wide impact on health around the world that is associated with neoplastic diseases. Epigenetic mechanisms have a central role in the obesogenic environment, which participates on the development of comorbidities such as cancer. METHODS AND RESULTS: We made an exhaustive review of the most recent reports about metabolic disorders with nutrition and their relationship with miRNAs, and their risk of developing into oncogenic processes...
June 8, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28590147/screening-of-cardiovascular-risk-factors-in-patients-with-schizophrenia-and-patients-treated-with-antipsychotic-drugs-are-we-equally-exhaustive-as-with-the-general-population
#11
Miguel Castillo-Sánchez, Mireia Fàbregas-Escurriola, Daniel Bergè-Baquero, MªIsabel Fernández-SanMartín, Albert Goday-Arno
Many studies have previously shown increased cardiovascular risk factors related to schizophrenia independently from the use of antipsychotic drugs. However, a poorer effort in clinical detection and management of cardiovascular risk in patients with severe mental illness could also explain these results. To test this hypothesis, we analyzed the differences in screening and incidence of cardiovascular risk factors between schizophrenia, non-schizophrenic patients on treatment with antipsychotic drugs (NS-TAD) and the general population...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28557192/the-quebec-experience-in-promoting-healthy-lifestyles-and-preventing-obesity-how-can-we-do-better
#12
REVIEW
Y Le Bodo, C Blouin, N Dumas, P De Wals, J Laguë
Over the last years, many actions have been implemented in the Canadian province of Quebec to prevent health issues related to diet, physical activity and obesity. As a new public health programme is being launched, the 'How can we do better?' project aimed to identify priority areas for further action. An exhaustive search led to identify 166 interventions rolled out in Quebec between 2006 and 2014. We compared it with evidence-based recommendations. Findings were challenged during a 2-d deliberative forum gathering 25 key stakeholders...
May 30, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28524250/one-plant-many-uses-a-review-of-the-pharmacological-applications-of-morinda-citrifolia
#13
REVIEW
Mylena Andréa Oliveira Torres, Isadora de Fátima Braga Magalhães, Renata Mondêgo-Oliveira, Joicy Cortez de Sá, Alessandra Lima Rocha, Ana Lucia Abreu-Silva
Morinda citrifolia, also known as noni, is commonly used in popular medicine in Brazil. Many parts of the noni tree are utilized in such practices, including the roots, leaves and seeds. Through a search of online databases, the present article reviews 92 research studies on the biological actions of M. citrifolia. The paper will discuss the therapeutic effects of noni and its compounds in a variety of forms of presentation, focusing on studies that support its traditional use. A large and diverse number of properties were identified, which were divided into immunostimulatory, antitumor, antidiabetic, anti-obesity, antibacterial and anti-septic, antifungal, antiviral, leishmanicidal, antiinflammatory, antinociceptive and analgesic, antioxidant, neuroprotective, wound healing, antiallergic, antiangiogenic, antiemetic and anti-nausea, anti-gastric ulcer and oesophagitis, anthelmintic, antimutagenic, antipsychotic, anxiolytic, photoprotective, anti-wrinkle and periodontal tissue regeneration activities...
May 19, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28474869/improvements-in-chilean-patients-with-obesity-following-a-5-month-multidisciplinary-exercise-program-a-feasibility-study
#14
Pedro Delgado-Floody, Felipe Caamaño-Navarrete, Javier Gonzalez-Rivera, Johannes Fleckenstein, Winfried Banzer, Cristian Martinez Salazar
OBJECTIVE: To determine the effects of a multidisciplinary exercise program on physical fitness, metabolic profile and nutritional status of obese patients. METHODS: Seventeen women and four men (n=21, age 18 to 60 years), with severe obesity (BMI = 35-40 kg/m2, n=7), morbid obesity (BMI = 40-50 kg/m2, n=9), and super obesity (BMI > 50 kg/m2, n=5), took part in a physical exercise program with nutritional and psychological support. The intermittent physical exercise program was applied three times per week (1 hour/session), with 4-8 exercises with weights...
April 26, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28457682/-quality-of-life-measures-in-sle-an-update
#15
H Devilliers, N Vernier, G Muller, A Turcu, M Samson, P Bielefeld, J-F Besancenot
Systemic lupus erythematosus (SLE) is a chronic disease that considerably hampers patient's daily living. Qualitative studies with patients' interviews have been conducted to describe the experiences and perspectives of adults living with SLE. Among existing generic and disease-specific quality of life (QOL) questionnaires, none succeeded to exhaustively measure patient's preoccupations. However, these tools are useful to quantify the burden of the disease. Social precariousness, socioeconomic status and education level are intimately correlated to QOL measures, either generic or disease-specific...
April 27, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28425847/form-ul-ation-of-adipocytes-by-lipids
#16
Kfir Lapid, Jonathan M Graff
Lipids have the potential to serve as bio-markers, which allow us to analyze and to identify cells under various experimental settings, and to serve as a clinical diagnostic tool. For example, diagnosis according to specific lipids that are associated with diabetes and obesity. The rapid development of mass-spectrometry techniques enables identification and profiling of multiple types of lipid species. Together, lipid profiling and data interpretation forge the new field of lipidomics. Lipidomics can be used to characterize physiologic and pathophysiological processes in adipocytes, since lipid metabolism is at the core of adipocyte physiology and energy homeostasis...
March 1, 2017: Adipocyte
https://www.readbyqxmd.com/read/28400989/serum-leptin-concentration-is-associated-with-incident-frailty-in-older-adults
#17
Alberto Lana, Ana Valdés-Bécares, Antonio Buño, Fernando Rodríguez-Artalejo, Esther Lopez-Garcia
Obesity has been associated with higher risk of frailty in older adults, but the pathophysiological mechanisms are unclear. No previous study has examined the association between leptin, an adipokine, and the risk of frailty in older adults, and whether this association could be explained by insulin resistance or chronic inflammation. Data were taken from 1,573 individuals without diabetes mellitus, aged ≥60 years, from the Seniors-ENRICA cohort. In 2008-2010, leptin, the homeostasis model assessment of insulin resistance (HOMA-IR) and C-reactive protein (CRP) were measured...
April 2017: Aging and Disease
https://www.readbyqxmd.com/read/28355342/association-of-weight-control-behaviors-with-body-mass-index-and-weight-based-self-evaluation
#18
Sabrina Chapuis-de-Andrade, Rafael M de Araujo, Diogo R Lara
OBJECTIVE: To determine the frequency of weight control behaviors (WCBs) and their correlation with body mass index (BMI) and weight-based self-evaluation. METHODS: Data were collected by the Brazilian Internet Study on Temperament and Psychopathology (BRAINSTEP) from 27,501 volunteers (30.4% men, mean age 28.9±8.7 years). RESULTS: The most prevalent WCBs for men and women were exhaustive physical exercise and prolonged fasting, respectively...
March 23, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28333140/metabolic-and-molecular-insights-into-an-essential-role-of-nicotinamide-phosphoribosyltransferase
#19
Li Q Zhang, Leon Van Haandel, Min Xiong, Peixin Huang, Daniel P Heruth, Charlie Bi, Roger Gaedigk, Xun Jiang, Ding-You Li, Gerald Wyckoff, Dmitry N Grigoryev, Li Gao, Linheng Li, Min Wu, J Steven Leeder, Shui Qing Ye
Nicotinamide phosphoribosyltransferase (NAMPT) is a pleiotropic protein implicated in the pathogenesis of acute respiratory distress syndrome, aging, cancer, coronary heart diseases, diabetes, nonalcoholic fatty liver disease, obesity, rheumatoid arthritis, and sepsis. However, the underlying molecular mechanisms of NAMPT in these physiological and pathological processes are not fully understood. Here, we provide experimental evidence that a Nampt gene homozygous knockout (Nampt(-/-)) resulted in lethality at an early stage of mouse embryonic development and death within 5-10 days in adult mice accompanied by a 25...
March 23, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28329052/acute-coronary-syndrome-in-women-rising-hospitalizations-in-middle-aged-french-women-2004-14
#20
Amélie Gabet, Nicolas Danchin, Yves Juillière, Valérie Olié
Aims: We aimed to analyse trends in annual incidence of hospitalized acute coronary syndrome (ACS) in France from 2004 to 2014. Methods and results: Primary diagnosis of ACS and subtypes on admissions were selected in national and exhaustive French Hospitalization Database from 2004 to 2014. Age-standardized rates were computed using standardization on the census of the 2010 European population and mean annual percent changes were estimated by using Poisson regression model...
March 11, 2017: European Heart Journal
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