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https://www.readbyqxmd.com/read/29713389/establishing-post-mortem-criteria-for-the-metabolic-syndrome-an-autopsy-based-cross-sectional-study
#1
Martin Roest Christensen, Anne Bugge, Mariam Elmegaard Malik, Jørgen Lange Thomsen, Niels Lynnerup, Jørgen Rungby, Jytte Banner
Background: Individuals who suffer from mental illness are more prone to obesity and related co-morbidities, including the metabolic syndrome. Autopsies provide an outstanding platform for the macroscopic, microscopic and molecular-biological investigation of diseases. Autopsy-based findings may assist in the investigation of the metabolic syndrome. To utilise the vast information that an autopsy encompasses to elucidate the pathophysiology behind the syndrome further, we aimed to both develop and evaluate a method for the post mortem definition of the metabolic syndrome...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29693429/ergogenic-effects-of-beetroot-juice-supplementation-during-severe-intensity-exercise-in-obese-adolescents
#2
Letizia Rasica, Simone Porcelli, Mauro Marzorati, Desy Salvadego, Alessandra Vezzoli, Fiorenza Agosti, Alessandra De Col, Gabriella Tringali, Andrew M Jones, Alessandro Sartorio, Bruno Grassi
Previous studies showed a higher O2 cost of exercise, and therefore a reduced exercise tolerance, in obese patients during constant work rate (CWR) exercise compared to healthy subjects. Among the ergogenic effects of dietary nitrate (NO3 -) supplementation in sedentary healthy subjects, a reduced O2 cost and enhanced exercise tolerance have often been demonstrated. The aim of this study was to evaluate the effects of beetroot juice supplementation, rich in NO3 -, on physiological variables associated with exercise tolerance in obese adolescents...
April 25, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29679542/treatments-for-diabetes-mellitus-type-ii-new-perspectives-regarding-the-possible-role-of-calcium-and-camp-interaction
#3
REVIEW
Diego Soares Carvalho, Alexandre Aparecido de Almeida, Aurélio Ferreira Borges, Vannucci Campos
Diabetes mellitus (DM) is among the top ten causes of death worldwide. It is considered to be one of the major global epidemics of the 21st century, with a significant impact on public health budgets. DM is a metabolic disorder with multiple etiologies. Its pathophysiology is marked by dysfunction of pancreatic β-cells which compromises the synthesis and secretion of insulin along with resistance to insulin action in peripheral tissues (muscle and adipose). Subjects presenting insulin resistance in DM type 2 often also exhibit increased insulin secretion and hyperinsulinemia...
April 19, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29575149/exercise-decreases-clk2-in-the-liver-of-obese-mice-and-prevents-hepatic-fat-accumulation
#4
Vitor R Muñoz, Rafael C Gaspar, Gabriel K Kuga, Susana C B R Nakandakari, Igor L Baptista, Rania A Mekary, Adelino S R da Silva, Leandro P de Moura, Eduardo R Ropelle, Dennys E Cintra, José R Pauli
The accumulation of fatty acids in the liver associated with obesity condition is also known as nonalcoholic fatty liver disease (NAFLD). The impaired fat oxidation in obesity condition leads to increased hepatic fat accumulation and increased metabolic syndrome risk. On the other hand, physical exercise has been demonstrated as a potent strategy in the prevention of NAFLD. Also, these beneficial effects of exercise occur through different mechanisms. Recently, the Cdc2-like kinase (CLK2) protein was associated with the suppression of fatty acid oxidation and hepatic ketogenesis...
March 25, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29474207/health-related-fitness-in-preschool-children-with-and-without-motor-delays
#5
Sara King-Dowling, Christine Rodriguez, Cheryl Missiuna, Brian W Timmons, John Cairney
PURPOSE: School-age children with Developmental Coordination Disorder (DCD) have poor health-related fitness (HRF), but little is known about when these deficits emerge. The purpose of this study was to determine if 4- and 5-year old children who meet the criteria for DCD exhibit poorer HRF than typically developing (TD) children, and if this relationship is mediated by vigorous physical activity (VPA) engagement. METHODS: Five-hundred and ninety-two children participated (age 5...
February 23, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29444341/high-fat-diet-induced-obesity-promotes-expansion-of-bone-marrow-adipose-tissue-and-impairs-skeletal-stem-cell-functions-in-mice
#6
Michaela Tencerova, Florence Figeac, Nicholas Ditzel, Hanna Taipaleenmäki, Tina Kamilla Nielsen, Moustapha Kassem
Obesity represents a risk factor for development of insulin resistance and type 2 diabetes. In addition, it has been associated with increased adipocyte formation in the bone marrow (BM) along with increased risk for bone fragility fractures. However, little is known on the cellular mechanisms that link obesity, BM adiposity, and bone fragility. Thus, in an obesity intervention study in C57BL/6J mice fed with a high-fat diet (HFD) for 12 weeks, we investigated the molecular and cellular phenotype of bone marrow adipose tissue (BMAT), BM progenitor cells, and BM microenvironment in comparison to peripheral adipose tissue (AT)...
February 14, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29362939/human-development-index-children-s-health-related-quality-of-life-and-movement-behaviors-a-compositional-data-analysis
#7
Dorothea Dumuid, Carol Maher, Lucy K Lewis, Tyman E Stanford, Josep Antoni Martín Fernández, Julie Ratcliffe, Peter T Katzmarzyk, Tiago V Barreira, Jean-Philippe Chaput, Mikael Fogelholm, Gang Hu, José Maia, Olga L Sarmiento, Martyn Standage, Mark S Tremblay, Catrine Tudor-Locke, Timothy Olds
PURPOSE: Health-related quality of life has been related to physical activity, sedentary behavior, and sleep among children from developed nations. These relationships have rarely been assessed in developing nations, nor have behaviors been considered in their true context, as mutually exclusive and exhaustive parts of the movement behavior composition. This study aimed to explore whether children's health-related quality of life is related to their movement behavior composition and if the relationship differs according to human development index...
January 23, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29357508/early-blood-pressure-response-to-isometric-exercise-is-attenuated-in-obese-individuals-who-have-undergone-bariatric-surgery
#8
Jacqueline K Limberg, Winston Guo, Michael J Joyner, Nisha Charkoudian, Timothy B Curry
Blood pressure (BP) reactivity is predictive of the development of cardiovascular disease. We hypothesized that the BP response at the onset of isometric handgrip exercise would occur earlier and to a lesser degree in individuals who underwent bariatric surgery compared with obese adults and that the reliance on total peripheral resistance (TPR) would be attenuated. Twenty-six individuals (7 nonobese, 11 obese, 8 postbariatric surgery) completed isometric handgrip exercise (40% maximum voluntary contraction) to exhaustion...
April 1, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29300416/the-association-between-bmi-and-different-frailty-domains-a-u-shaped-curve
#9
M L Rietman, D L van der A, S H van Oostrom, H S J Picavet, M E T Dollé, H van Steeg, W M M Verschuren, A M W Spijkerman
OBJECTIVES: Previous studies showed a U-shaped association between BMI and (physical) frailty. We studied the association between BMI and physical, cognitive, psychological, and social frailty. Furthermore, the overlap between and prevalence of these frailty domains was examined. DESIGN: Cross-sectional study. SETTING: The Doetinchem Cohort Study is a longitudinal population-based study starting in 1987-1991 examining men and women aged 20-59 with follow-up examinations every 5 yrs...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29207219/-donor-and-recipient-selection-in-living-donor-kidney-transplantation-eligibility
#10
REVIEW
Marilena Gregorini, Eleonora Francesca Pattonieri, Gianluca Fasoli, Mauro Valente, Edoardo La Porta, Michele Canevari, Fulvia Erasmi, Teresa Rampino
This review is intended to be a guide for the physician to evaluate and prepare a donor / recipient couple for living kidney transplantation. Although it is intended to be exhaustive, it will not be able to respond at all possible and different cases, but it may apply at most of them. Renal transplantation is considered the choice treatment for patients with chronic renal failure and if the kidney transplant is performed pre-emptive it is associated with better organ and patient survival. The main aim of the program is to evaluate the risks of donor and recipient and to ensure the donor safety and well-being...
December 5, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29141620/treatment-of-genu-valgum-in-children-by-means-of-temporary-hemiepiphysiodesis-using-eight-plates-short-term-findings
#11
Dirk Zajonz, Eckehard Schumann, Magdalena Wojan, Fabian B Kübler, Christoph Josten, Ulf Bühligen, Christoph E Heyde
BACKGROUND: Idiopathic genu valgum is a frequently diagnosed growth disorder in adolescence. Whenever the possibilities of conservative therapy have been exhausted, leg straightening by means of hemiepiphysiodesis has become the standard form of treatment. Because of their flexible screw-plate connection, eight-Plates have been reported in the literature to lead to lower complications regarding implant loosening and fracture compared to other implants. The aim of this retrospective survey was to analyse our own patient population who were treated for genu valgum by means of temporary hemiepiphysiodesis near the knee using eight-Plates to modulate growth...
November 15, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29112877/weakness-the-most-frequent-criterion-among-pre-frail-and-frail-older-portuguese
#12
A R Sousa-Santos, C Afonso, P Moreira, P Padrão, A Santos, N Borges, T F Amaral
AIM: In Portugal, the burden of pre-frailty and frailty in community-dwelling older adults is still unknown. The purpose of this study is to estimate the frequency of frailty in a Portuguese sample with ≥ 65years and to evaluate its associated factors. We also intend to identify which criterion has more impact on the diagnosis of frailty. METHODS: 1457 older adults with ≥ 65years from the Nutrition UP 65 study were evaluated in a cross-sectional analysis...
January 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29040163/adipose-tissue-is-enriched-for-activated-and-late-differentiated-cd8-t-cells-and-shows-distinct-cd8-receptor-usage-compared-with-blood-in-hiv-infected-persons
#13
John R Koethe, Wyatt McDonnell, Arion Kennedy, Chike O Abana, Mark Pilkinton, Ian Setliff, Ivelin Georgiev, Louise Barnett, Cindy C Hager, Rita Smith, Spyros A Kalams, Alyssa Hasty, Simon Mallal
BACKGROUND: Adverse viral and medication effects on adipose tissue contribute to the development of metabolic disease in HIV-infected persons, but T cells also have a central role modulating local inflammation and adipocyte function. We sought to characterize potentially proinflammatory T-cell populations in adipose tissue among persons on long-term antiretroviral therapy and assess whether adipose tissue CD8 T cells represent an expanded, oligoclonal population. METHODS: We recruited 10 HIV-infected, non-diabetic, overweight or obese adults on efavirenz, tenofovir, and emtricitabine for >4 years with consistent viral suppression...
February 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28989252/operculina-turpethum-linn-silva-manso-as-a-medicinal-plant-species-a-review-on-bioactive-components-and-pharmacological-properties
#14
REVIEW
Shweta Gupta, Akash Ved
Operculina turpethum (Linn.) (OT) Silva Manso belongs to the family Convolvulaceae. This review incorporates literature for the phytochemical and pharmacological profile of OT herb. Exhaustive literature survey was done using all the details on phytochemistry and pharmacology of OT available. This herb was found to be a potent source of bioactive compounds such as α- and β-turpethein, turpethinic acids (A, B, C, D, and E), coumarins, cycloartenol, lanosta-5-ene, 24-methylene-δ-5-lanosterol, α- and β-rhamnose, β-sitosterol, lupeol, scopoletin, betulin, acrylamide, stigma-5,22dien-3-O-β-D-glucopyranoside, β-sitosterol-β-D-glucoside (H-1), 22,23-dihydro-α-spinosterol-β-D-glucoside (H-2), and salicylic acid (CH-2), which are useful in fevers, edema, ascites, anorexia, constipation, hepatosplenomegaly, hemorrhoids, cervical lymphadenitis, fistulas, constipation, chronic gout, fever, bronchitis, ulcers, hemorrhoids, tumors, obesity, jaundice, herpes, induce lacrimation, and other skin disorders...
July 2017: Pharmacognosy Reviews
https://www.readbyqxmd.com/read/28978986/the-relationship-between-obesity-and-hypertension-an-updated-comprehensive-overview-on-vicious-twins
#15
REVIEW
Massimo Leggio, Mario Lombardi, Elisa Caldarone, Paolo Severi, Stefania D'Emidio, Massimo Armeni, Veronica Bravi, Maria Grazia Bendini, Andrea Mazza
Obesity is a growing global health concern, with a rapid increase being observed in morbid obesity. Obesity is associated with an increased cardiovascular risk and earlier onset of cardiovascular morbidity. The growing obesity epidemic is a major source of unsustainable health costs and morbidity and mortality because of hypertension, type 2 diabetes mellitus, dyslipidemia, certain cancers and major cardiovascular diseases. Similar to obesity, hypertension is a key unfavorable health metric that has disastrous health implications: currently, hypertension is the leading contributor to global disease burden, and the direct and indirect costs of treating hypertension are exponentially higher...
December 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28966617/peripheral-autoimmune-regulator-induces-exhaustion-of-cd4-and-cd8-effector-t-cells-to-attenuate-autoimmune-diabetes-in-non-obese-diabetic-mice
#16
Divakar Kulshrestha, Li-Tzu Yeh, Ming-Wei Chien, Feng-Cheng Chou, Huey-Kang Sytwu
Autoimmune regulator (Aire) is one of the most crucial genes expressed in the thymus, where it orchestrates the promiscuous expression and presentation of tissue-specific antigens during thymocyte selection. The presence of Aire-expressing cells outside the thymus points toward its plausible extrathymic functions; however, the relative contribution of Aire-expressing cells of hematopoietic origin and their role in the modulation of autoimmune diseases are still obscure. Here, we report that non-obese diabetic mice with transgenic Aire expression under the control of the CD11c (integrin alpha X) promoter were significantly protected from autoimmune diabetes compared with their non-transgenic littermates...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28884594/predicting-failure-of-nonoperative-treatment-for-insertional-achilles-tendinosis
#17
James F Stenson, Christopher W Reb, Joseph N Daniel, Sundeep S Saini, Mohammed F Albana
Nonoperative treatment for midportion Achilles tendinosis is well defined by the literature. Multiple modalities are described for the management of insertional Achilles pathology, but no consensus exists regarding efficacy. Surgical intervention for insertional Achilles tendinosis (IAT) is successful greater than 80% of the time. Our objective was to risk stratify patients who would fail nonsurgical management of IAT and thus benefit progressing to surgery. We reviewed the records of 664 patients with IAT...
September 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28869169/-temocillin-and-urinary-tract-infections
#18
M Vallée, F Bruyère, F Roblot, L Brureau
INTRODUCTION: Temocillin is an alternative to treat urinary tract infections with bacteria producing extended spectrum beta-lactamase (ESBL). The objective is to evaluate the use of temocillin in urinary tract infections. MATERIALS AND METHODS: A systematic review of literature was carried out according to PRISMA criteria. All national and international recommendations have been reviewed regarding the indication of the use of temocillin in urology. Data collection on the use of temocillin in urinary tract infection has been performed from the Cochrane, LILACS and the Medline database...
October 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28782491/the-impact-of-cardiovascular-diseases-on-cardiovascular-regulation-during-exercise-in-humans-studies-on-metaboreflex-activation-elicited-by-the-post-exercise-muscle-ischemia-method
#19
REVIEW
Antonio Crisafulli
BACKGROUND: Hemodynamics during dynamic exercise is finely regulated by some neural mechanisms. One of these mechanisms is the metabolic part of the exercise pressor reflex, i.e. the muscle metaboreflex. Hemodynamic response during the metaboreflex is characterised by the recruitment of the reserves in cardiac inotropism, pre-load, after-load and chronotropism. If one of these reserves is exhausted, then the cardiovascular response is achieved by recruiting one of the other reserves, thereby indicating a remarkable plasticity of the control of circulation...
2017: Current Cardiology Reviews
https://www.readbyqxmd.com/read/28721028/frailty-in-community-dwelling-older-adults-association-with-adverse-outcomes
#20
Sergio Sánchez-García, Carmen García-Peña, Antoni Salvà, Rosalinda Sánchez-Arenas, Víctor Granados-García, Juan Cuadros-Moreno, Laura Bárbara Velázquez-Olmedo, Ángel Cárdenas-Bahena
BACKGROUND: The study of frailty is important to identify the additional needs of medical long-term care and prevent adverse outcomes in community dwelling older adults. This study aimed to determine the prevalence of frailty and its association with adverse outcomes in community dwelling older adults. METHODS: A cross-sectional study was carried out from April to September 2014. The population sample was 1,252 older adults (≥60 years) who were beneficiaries of the Mexican Institute of Social Security (IMSS) in Mexico City...
2017: Clinical Interventions in Aging
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