Kevin Englebert, Anaelle Taquin, Abdulkader Azouz, Valérie Acolty, Sylvie Vande Velde, Marie Vanhollebeke, Hadrien Innes, Louis Boon, Tibor Keler, Oberdan Leo, Stanislas Goriely, Muriel Moser, Guillaume Oldenhove
Adipose tissue homeostasis relies on the interplay between several regulatory lineages, such as type 2 innate lymphoid cells (ILC2s), T helper 2 (Th2) cells, regulatory T cells, eosinophils, and type 2 macrophages. Among them, ILC2s are numerically the dominant source of type 2 cytokines and are considered as major regulators of adiposity. Despite the overlap in immune effector molecules and sensitivity to alarmins (thymic stromal lymphopoietin and interleukin-33) between ILC2s and resident memory Th2 lymphocytes, the role of the adaptive axis of type 2 immunity remains unclear...
February 20, 2024: Cell Reports