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https://www.readbyqxmd.com/read/29331088/significance-of-circulatory-dpp4-activity-in-metabolic-diseases
#1
REVIEW
Titli Nargis, Partha Chakrabarti
Dipeptidyl peptidase 4 (DPP4), also known as CD26 is a type II transmembrane protein that is released from the cell membrane in a nonclassical secretory mechanism. This exopeptidase selectively degrades varieties of substrates including incretin hormones, growth factors, and cytokines. A significant detectable amount of DPP4 activity can be measured in plasma as well as in different tissues such as intestinal epithelium, vascular endothelium, lymphocytes, monocytes, kidney, liver, adipose, lung, thymus, spleen, prostate, etc...
January 13, 2018: IUBMB Life
https://www.readbyqxmd.com/read/29326816/immune-checkpoint-inhibition-prospects-for-prevention-and-therapy-of-hepatocellular-carcinoma
#2
REVIEW
Caryn L Elsegood, Janina Ee Tirnitz-Parker, John K Olynyk, George Ct Yeoh
The global prevalence of liver cancer is rapidly rising, mostly as a result of the amplified incidence rates of viral hepatitis, alcohol abuse and obesity in recent decades. Treatment options for liver cancer are remarkably limited with sorafenib being the gold standard for advanced, unresectable hepatocellular carcinoma but offering extremely limited improvement of survival time. The immune system is now recognised as a key regulator of cancer development through its ability to protect against infection and chronic inflammation, which promote cancer development, and eliminate tumour cells when present...
November 2017: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/29325323/-platelet-to-lymphocyte-ratio-in-peripheral-blood-and-body-mass-index-novel-independent-prognostic-factors-in-patients-with-melanoma
#3
Y L Qi, Y Zhang, L D Zhao, A X Wang, Z B Wang, Q L Gao
Objective: To investigate whether platelet to lymphocyte ratio (PLR) in peripheral blood and body mass index (BMI) can be independent prognostic factors in patients with melanoma. Methods: Clinical date of 140 patients with melanoma in the Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital from January 1, 2010 to December 31, 2015 were analyzed retrospectively.Receiver operating characteristic (ROC) curve was performed the optimal cut-off value for PLR.The 140 patients were divided into high PLR group and low PLR group...
December 19, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29289901/established-and-suggested-exposures-on-cll-sll-etiology-results-from-the-cll-mcc-spain-study
#4
Yolanda Benavente, Delphine Casabonne, Laura Costas, Claudia Robles, Esther Alonso, Esmeralda de la Banda, Eva Gonzalez-Barca, Rafael Marcos-Gragera, Javier Llorca, Adonina Tardón, José J Monleon, Marta Aymerich, Elías Campo, Eva Gimeno-Vázquez, Gemma Castaño-Vinyals, Nuria Aragonés, Marina Pollán, Manolis Kogevinas, Sílvia de Sanjosé
INTRODUCTION: Chronic Lymphocytic Leukemia (CLL/SLL) is the most common adult leukemia in Western countries. Although it is mostly an indolent disease it is still incurable and with limited knowledge in relation to its etiology. We aim to confirm and quantify established risk factors for CLL/SLL using a multi-center epidemiological population-based case-control study on CLL/SLL as well as to explore new exposures inconclusively associated with CLL/SLL METHODS: Using the framework provided by the large MCC-Spain case-control study, we explored established and suggested risk factors associated with CLL/SLL using data collected through a face-to-face interview...
December 28, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29275470/lipid-inflammatory-mediators-in-cancer-progression-and-therapy
#5
Saraswoti Khadge, John Graham Sharp, Timothy R McGuire, Geoffrey M Thiele, James E Talmadge
Rodent and clinical studies have documented that myeloid cell infiltration of tumors is associated with neutrophilia, lymphocytopenia and poor patient outcomes. This contrasts with lymphocyte infiltration of tumors, which is associated with improved outcomes. Lifestyle parameters such as high fat diet s and omega (ω)-6 polyunsaturated fatty acids (PUFA) intake may influence these inflammatory parameters including extramedullary myelopoiesis that can contribute to a metastatic "niche". While, tumor secretion of growth factors (GFs) and chemokines regulate tumor-immune-cell crosstalk, in this chapter, we also emphasize how lifestyle choices, including, obesity, high-fat and high ω-6 PUFA dietary content, contribute to inflammation and myeloid cell infiltration of tumors...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29247296/decrease-of-perforin-positive-cd3-%C3%AE-%C3%AE-t-cells-in-patients-with-obstructive-sleep-disordered-breathing
#6
Richard Staats, Raquel Rodrigues, André Barros, Leonor Bacelar-Nicolau, Margarida Aguiar, Dina Fernandes, Susana Moreira, André Simões, Bruno Silva-Santos, João Valença Rodrigues, Cristina Barbara, António Bugalho de Almeida, Luis Ferreira Moita
INTRODUCTION: Sleep related breathing disorders (SRBD) cause sleep fragmentation, intermittent hypoxia or a combination of both leading to homeostasis perturbations, including in the immune system. We investigated whether SRBD patients with or without intermittent hypoxia show substantial differences in perforin and granzyme-B positive peripheral blood lymphocytes. METHODS: A total of 87 subjects were included and distributed as follows: 24 controls (C), 19 patients with respiratory effort related arousals due to increased upper airway resistance (UAR) without hypoxic events, 24 obese patients with obstructive sleep apnea (OSA) (oOSA), and 20 without obesity (noOSA)...
December 15, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29223125/tgf-%C3%AE-and-inflammatory-blood-markers-in-prediction-of-intraperitoneal-adhesions
#7
Kamil Torres, Łukasz Pietrzyk, Zbigniew Plewa, Karolina Załuska-Patel, Mariusz Majewski, Elżbieta Radzikowska, Anna Torres
PURPOSE: Intraperitoneal adhesions (IA) develop as a consequence of the healing process in peritoneum injured during surgeries. IA might be formed after all types of surgical interventions regardless the surgical approach with a higher incidence in obese individuals. Here we determine the diagnostic power of TGF-β and blood inflammatory parameters in the prediction of IA in obese patients undergoing second surgical intervention. MATERIALS AND METHODS: Eighty patients were divided into groups according to body mass index (BMI) values and presence of intraperitoneal adhesions (IA)...
December 6, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29218110/downregulation-of-cathepsin-g-reduces-the-activation-of-cd4-t-cells-in-murine-autoimmune-diabetes
#8
Fang Zou, Xiaoyang Lai, Jing Li, Shuihong Lei, Lei Hu
Type 1 diabetes mellitus (T1DM) is an autoimmune disease due to progressive injury of islet cells mediated by T lymphocytes (T cells). Our previous studies have shown that only cathepsin G (CatG), not other proteases, is involved in the antigen presentation of proinsulin, and if the presentation is inhibited, the activation of CD4+ T cells induced by proinsulin is alleviated in T1DM patients, and CatG-specific inhibitor reduces the activation of CD4+ cells induced by proinsulin in T1DM patients. Therefore, we hypothesize that CatG may play an important role in the activation of CD4+ T cells in T1DM...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29217263/the-dietary-inflammatory-index-is-associated-with-elevated-white-blood-cell-counts-in-the-national-health-and-nutrition-examination-survey
#9
Michael D Wirth, Maria Sevoyan, Lorne Hofseth, Nitin Shivappa, Thomas G Hurley, James R Hébert
White blood cells (WBCs) are considered a reliable biomarker of inflammation. Elevations in both WBCs and pro-inflammatory cytokines are associated with several chronic conditions. Diet is a strong moderator of inflammation and WBCs. The purpose of this study was to examine the association between the Dietary Inflammatory Index (DII®) and WBCs using data from the United States National Health and Nutrition Examination Survey (NHANES). NHANES is a cross-sectional study that occurs in two-year cycles. Respondents from five cycles (n=26,046) with available data on diet (collected through a single 24-hour dietary recall [24HR]) and WBCs (derived using the Coulter method) were included...
December 4, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29179679/attenuating-the-rate-of-total-body-fat-accumulation-and-alleviating-liver-damage-by-oral-administration-of-vitamin-d-enriched-edible-mushrooms-in-a-diet-induced-obesity-murine-model-is-mediated-by-an-anti-inflammatory-paradigm-shift
#10
A Drori, D Rotnemer-Golinkin, S Avni, A Drori, O Danay, D Levanon, J Tam, L Zolotarev, Y Ilan
BACKGROUND: Hypovitaminosis D is associated with many features of the metabolic syndrome, including non-alcoholic fatty liver disease. Vitamin D-enriched mushrooms extracts exert a synergistic anti-inflammatory effect. The aim of the present study is to determine the immunomodulatory effect of oral administration of vitamin D-enriched mushrooms extracts on high-fat diet (HFD) animal model of non-alcoholic steatohepatitis (NASH). METHODS: C57BL/6 mice on HFD were orally administered with vitamin D supplement, Lentinula edodes (LE) mushrooms extract, or vitamin D-enriched mushrooms extract for 25 weeks...
November 28, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29159964/blocking-antibodies-induced-by-allergen-specific-immunotherapy-ameliorate-allergic-airway-disease-in-a-human-mouse-chimeric-model
#11
Caterina Vizzardelli, Miriam Gindl, Simone Roos, Christian Möbs, Birgit Nagl, Felix Zimmann, Veronika Sexl, Lukas Kenner, Alina Neunkirchner, Gerhard J Zlabinger, Winfried F Pickl, Wolfgang Pfützner, Barbara Bohle
BACKGROUND: Allergen-specific immunotherapy (AIT) induces specific blocking antibodies (Ab) which are claimed to prevent IgE-mediated reactions to allergens. Additionally, AIT modulates cellular responses to allergens, e.g. by desensitizing effector cells, inducing regulatory T and B lymphocytes and immune deviation. It is still enigmatic which of these mechanisms mediate(s) clinical tolerance. We sought to address the role of AIT-induced blocking Ab separately from cellular responses in a chimeric human/mouse model of respiratory allergy...
November 21, 2017: Allergy
https://www.readbyqxmd.com/read/29150385/igf-1r-mrna-expression-is-increased-in-obese-children
#12
Rafaela Cristina Ricco, Rubens Garcia Ricco, Mariangela Carletti Queluz, Mariana Teresa Sarti de Paula, Patricia Volpon Atique, Rodrigo José Custódio, Hugo Tourinho Filho, Raphael Del Roio Liberatori, Carlos Eduardo Martinelli
OBJECTIVES: Obese children are often taller than age-matched subjects. Reports on GH and IGF-I levels in obese individuals are controversial, with normal and reduced GH-IGF-I levels having been reported in this group of patients. Thus, the aim of this study was to analyse insulin-like growth factor type 1 receptor (IGF-IR) mRNA expression in obese children. METHODS: Forty-seven pre-pubertal children were included in this study: 29 were obese and taller than their target height, and 18 were normal eutrophic controls...
November 11, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29145611/identification-of-novel-potentially-pleiotropic-variants-associated-with-osteoporosis-and-obesity-using-cfdr-method
#13
Yuan Hu, Li-Jun Tan, Xiang-Ding Chen, Zhen Liu, Shi-Shi Min, Qin Zeng, Hui Shen, Hong-Wen Deng
Context: Genome-wide association studies (GWASs) have been successful in identifying loci associated with osteoporosis and obesity. However, the findings just explain a small fraction of the total genetic variance. Objective: The aim of this study was to identify novel pleiotropic genes important in osteoporosis and obesity. Design and Setting: A pleiotropic conditional false discovery rate (cFDR) method was applied to three independent GWAS summary statistics of femoral neck bone mineral density (FN BMD), body mass index (BMI) and waist-hip ratio (WHR)...
November 14, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29098499/functional-role-of-natural-killer-t-cells-in-non-obese-pre-diabetes-model-mice
#14
Mikako Saito, Misako Kaburagi, Keiko Otokuni, Genu Takahashi
Pre-diabetic patients have a high risk of developing diabetes as well as other associated diseases. From the viewpoint of risk assessment and to assist the development of protective therapies, we focused on the functional role of natural killer T (NKT) cells in pre-diabetes. We found that the expression of an NKT cell marker gene, Va14-Ja18, was significantly lower in specific tissues/organs such as adipose tissue and pancreas in non-obese pre-diabetes model mice than in their normal littermates. Subsequently, in the pre-diabetes model mice, Va14-Ja18 was activated with α-galactosylceramide (α-GalCer) and its effect on glucose tolerance was estimated...
November 2, 2017: Cytotechnology
https://www.readbyqxmd.com/read/29097999/clostridium-butyricum-cgmcc0313-1-protects-against-autoimmune-diabetes-by-modulating-intestinal-immune-homeostasis-and-inducing-pancreatic-regulatory-t-cells
#15
Lingling Jia, Kai Shan, Li-Long Pan, Ninghan Feng, Zhuwu Lv, Yajun Sun, Jiahong Li, Chengfei Wu, Hao Zhang, Wei Chen, Julien Diana, Jia Sun, Yong Q Chen
Recent evidence indicates that indigenous Clostridium species induce colonic regulatory T cells (Tregs), and gut lymphocytes are able to migrate to pancreatic islets in an inflammatory environment. Thus, we speculate that supplementation with the well-characterized probiotics Clostridium butyricum CGMCC0313.1 (CB0313.1) may induce pancreatic Tregs and consequently inhibit the diabetes incidence in non-obese diabetic (NOD) mice. CB0313.1 was administered daily to female NOD mice from 3 to 45 weeks of age. The control group received an equal volume of sterile water...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29080225/molecular-correlates-in-urine-for-the-obesity-and-prostatic-inflammation-of-bph-luts-patients
#16
Pradeep Tyagi, Saundra S Motley, Tatsuki Koyama, Mahendra Kashyap, Jeffrey Gingrich, Naoki Yoshimura, Jay H Fowke
PURPOSE: Benign prostatic hyperplasia (BPH) is strongly associated with obesity and prostatic tissue inflammation, but the molecular underpinning of this relationship is not known. Here, we examined the association between urine levels of chemokines/adipokines with histological markers of prostate inflammation, obesity, and lower urinary tract symptoms LUTS in BPH patients. METHODS: Frozen urine specimens from 207 BPH/LUTS patients enrolled in Nashville Men's Health Study were sent for blinded analysis of 11 analytes, namely sIL-1RA, CXC chemokines (CXCL-1, CXCL-8, CXCL-10), CC chemokines (CCL2, CCL3, CCL5), PDGF-BB, interleukins IL-6, IL-17, and sCD40L using Luminex™ xMAP® technology...
October 27, 2017: Prostate
https://www.readbyqxmd.com/read/29073286/differential-adipokine-receptor-expression-on-circulating-leukocyte-subsets-in-lean-and-obese-children
#17
Genoveva Keustermans, Laila B van der Heijden, Berlinda Boer, Rianne Scholman, Roos Nuboer, Gerard Pasterkamp, Berent Prakken, Wilco de Jager, Eric Kalkhoven, Arieke J Janse, Henk S Schipper
BACKGROUND: Childhood obesity prevalence has increased worldwide and is an important risk factor for type 2 diabetes (T2D) and cardiovascular disease (CVD). The production of inflammatory adipokines by obese adipose tissue contributes to the development of T2D and CVD. While levels of circulating adipokines such as adiponectin and leptin have been established in obese children and adults, the expression of adiponectin and leptin receptors on circulating immune cells can modulate adipokine signalling, but has not been studied so far...
2017: PloS One
https://www.readbyqxmd.com/read/29061165/sustained-endocrine-profiles-of-a-girl-with-wagr-syndrome
#18
Yui Takada, Yasunari Sakai, Yuki Matsushita, Kazuhiro Ohkubo, Yuhki Koga, Satoshi Akamine, Michiko Torio, Yoshito Ishizaki, Masafumi Sanefuji, Hiroyuki Torisu, Chad A Shaw, Masayo Kagami, Toshiro Hara, Shouichi Ohga
BACKGROUND: Wilms tumor, aniridia, genitourinary anomalies and mental retardation (WAGR) syndrome is a rare genetic disorder caused by heterozygous deletions of WT1 and PAX6 at chromosome 11p13. Deletion of BDNF is known eto be associated with hyperphagia and obesity in both humans and animal models; however, neuroendocrine and epigenetic profiles of individuals with WAGR syndrome remain to be determined. CASE PRESENTATION: We report a 5-year-old girl with the typical phenotype of WAGR syndrome...
October 23, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/29056000/-the-progress-of-studying-the-mechanisms-of-immune-cells-in-the-regulation-of-non-alcoholic-fatty-liver-diseases
#19
Y Bao
Non-alcoholic fatty liver diseases (NAFLD) are liver diseases which are strongly associated with obesity. The incidence of NAFLD has been gradually increased in recent years. According to different pathology of the liver, NAFLD include three disease states: simple fatty liver, hepatitis (nonalcoholic steatohepatitis, NASH) and fatty liver cirrhosis. The accumulations of fat around the internal organs, which secrete a wide range of adipokines, such as interleukin-6, contribute the development and progress of NAFLD in obesity...
July 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29046031/-innate-lymphoid-cells-and-their-role-in-immune-response-regulation
#20
Bibiana Patricia Ruiz-Sánchez, David Cruz-Zárate, Iris Estrada-García, Isabel Wong-Baeza
Innate lymphoid cells (ILCs) are lymphocytes lacking antigen recognition receptors and become activated in response to cytokines and through microbe-associated molecular pattern (MAMP) receptors. ILCs are found mainly in mucosal tissues and participate in the immune response against infections and in chronic inflammatory conditions. ILCs are divided in ILC-1, ILC-2 and ILC-3, and these cells have analogue functions to those of immune adaptive response lymphocytes Th1, Th2 and Th17. ILC-1 express T-bet, produce IFNγ, protect against infections with intracellular microorganisms and are related to inflammatory bowel disease immunopathology...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
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