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https://www.readbyqxmd.com/read/29760679/hematocrit-values-predict-carotid-intimal-media-thickness-in-obese-patients-with-non-alcoholic-fatty-liver-disease-a-cross-sectional-study
#1
Giovanni Tarantino, Luigi Barrea, Domenico Capone, Vincenzo Citro, Teresa Mosca, Silvia Savastano
Background: Literature data suggest with some criticism that full-fledged cardiovascular (CV) events (acute or chronic) are likely predicted by blood components, which are reported to be associated with the presence/severity of non-alcoholic fatty liver disease (NAFLD). This study was aimed at determining which marker(s) derived from blood count, such as white blood cells, neutrophils, neutrophil/lymphocyte ratio, platelet count, hemoglobin, mean corpuscular volume, hematocrit values were associated with ear or subclinical atherosclerosis, in obese patients of various classes suffering from NAFLD...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29760351/leptin-aggravates-reflux-esophagitis-by-increasing-tissue-levels-of-macrophage-migration-inhibitory-factor-in-rats
#2
Tsugihiro Murata, Kiyotaka Asanuma, Nobuyuki Ara, Katsunori Iijima, Waku Hatta, Shin Hamada, Naoki Asano, Tomoyuki Koike, Akira Imatani, Atsushi Masamune, Tooru Shimosegawa
Leptin, produced primarily by the adipose tissue, acts as a pro-inflammatory modulator, thereby contributing to the development of obesity-related disease. Although high levels of leptin in the obese are closely related to gastroesophageal reflux disease, the mechanism by which leptin influences esophageal inflammation remains unknown. Macrophage migration inhibitory factor (MIF) is produced by immune cells, such as T lymphocytes and macrophages, and MIF is known to induce the production of tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β) and interleukin 6 (IL-6)...
2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29758052/decreased-circulating-t-regulatory-lymphocytes-in-obese-patients-undergoing-bariatric-surgery
#3
Claudia Agabiti-Rosei, Valentina Trapletti, Silvia Piantoni, Paolo Airò, Angela Tincani, Carolina De Ciuceis, Claudia Rossini, Francesco Mittempergher, Amin Titi, Nazario Portolani, Stefano Caletti, Maria Antonietta Coschignano, Enzo Porteri, Guido A M Tiberio, Paola Pileri, Leonardo Solaini, Rajesh Kumar, Silvia Ministrini, Enrico Agabiti Rosei, Damiano Rizzoni
OBJECTIVE: It has been previously demonstrated that T lymphocytes may be involved in the development of hypertension and microvascular remodeling, and that circulating T effector lymphocytes may be increased in hypertension. In particular, Th1 and Th 17 lymphocytes may contribute to the progression of hypertension and microvascular damage while T-regulatory (Treg) lymphocytes seem to be protective in this regard. However, no data is available about patients with severe obesity, in which pronounced microvascular alterations were observed...
2018: PloS One
https://www.readbyqxmd.com/read/29746485/adiponectin-and-the-steatosis-marker-chi3l1-decrease-following-switch-to-raltegravir-compared-to-continued-pi-nnrti-based-antiretroviral-therapy
#4
Obiageli Offor, Netanya Utay, David Reynoso, Anoma Somasunderam, Judith Currier, Jordan Lake
BACKGROUND: People with HIV are at for metabolic syndrome (MetS) and fatty liver disease, but the role of Antiretroviral therapy (ART) is poorly understood. MetS and fatty liver disease been associated with changes in adiponectin, soluble ST2 (sST2), chitinase 3-like 1 (Chi3L1), hyaluronic acid (HA), tissue inhibitor of metalloproteinase-1 (TIMP-1), lysyl oxidase-like-2 (LOXL2) and transforming growth factor β (TGF-β) concentrations in HIV-uninfected populations. Protease (PI) and non-nucleoside reverse transcriptase inhibitors (NNRTI) may contribute to these comorbidities, but the effects of switching from PI- or NNRTI to raltegravir (RAL) on these biomarkers is unknown...
2018: PloS One
https://www.readbyqxmd.com/read/29740897/intracellular-free-magnesium-concentration-in-healthy-horses
#5
J C Winter, G Sponder, R Merle, J R Aschenbach, H Gehlen
Equine metabolic syndrome (EMS) is a worldwide disease in horses that parallels human diabetes mellitus type 2. In both diseases, patients show an altered peripheral insulin sensitivity as a key feature. In humans, multiple studies have demonstrated the beneficial effect of magnesium supplementation on insulin sensitivity. However, serum magnesium levels vary and are therefore not a reliable indicator of the patients' magnesium status. Determining the intracellular free magnesium concentration appears to be a more sensitive diagnostic indicator...
May 9, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29738416/design-and-protocol-of-estrogenic-regulation-of-muscle-apoptosis-erma-study-with-47-to-55-year-old-women-s-cohort-novel-results-show-menopause-related-differences-in-blood-count
#6
Vuokko Kovanen, Pauliina Aukee, Katja Kokko, Taija Finni, Ina M Tarkka, Tuija Tammelin, Urho M Kujala, Sarianna Sipilä, Eija K Laakkonen
OBJECTIVE: The multidisciplinary Estrogenic Regulation of Muscle Apoptosis (ERMA) study was designed to reveal how hormonal differences over the menopausal stages affect the physiological and psychological functioning of middle-aged women. This paper describes the protocol and nonrespondent analysis of ERMA and novel findings on menopausal differences in blood count variables and their association with female sex hormones. METHODS: Women aged 47 to 55 years were assigned to pre, early peri, late peri, and postmenopausal groups based on follicle-stimulating hormone (FSH) and bleeding diary...
May 7, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29722811/obesity-following-art-initiation-is-common-and-influenced-by-both-traditional-and-hiv-art-specific-risk-factors
#7
David R Bakal, Lara E Coelho, Paula M Luz, Jesse L Clark, Raquel B De Boni, Sandra W Cardoso, Valdilea G Veloso, Jordan E Lake, Beatriz Grinsztejn
Background: Obesity rates are increasing among HIV-infected individuals, but risk factors for obesity development on ART remain unclear. Objectives: In a cohort of HIV-infected adults in Rio de Janeiro, Brazil, we aimed to determine obesity rates before and after ART initiation and to analyse risk factors for obesity on ART. Methods: We retrospectively analysed data from individuals initiating ART between 2000 and 2015. BMI was calculated at baseline (time of ART initiation)...
May 2, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29707204/loss-of-zbtb32-in-nod-mice-does-not-significantly-alter-t-cell-responses
#8
William D Coley, Yongge Zhao, Charles J Benck, Yi Liu, Chie Hotta-Iwamura, M Jubayer Rahman, Kristin V Tarbell
Background : We previously identified the transcriptional regulator Zbtb32 as a factor that can promote T cell tolerance in the Non-Obese Diabetic (NOD) mouse, a model of Type 1 diabetes. Antigen targeted to DCIR2 + dendritic cells (DCs) in vivo inhibited both diabetes and effector T cell expansion in NOD mice. Furthermore, Zbtb32 was preferentially induced in autoreactive CD4 T cells stimulated by these tolerogenic DCIR2 + DCs, and overexpression of Zbtb32 in islet-specific T cells inhibited the diabetes development by limiting T cell proliferation and cytokine production...
2018: F1000Research
https://www.readbyqxmd.com/read/29695802/obesity-exacerbates-colitis-associated-cancer-via-il-6-regulated-macrophage-polarisation-and-ccl-20-ccr-6-mediated-lymphocyte-recruitment
#9
Claudia M Wunderlich, P Justus Ackermann, Anna Lena Ostermann, Petra Adams-Quack, Merly C Vogt, My-Ly Tran, Alexei Nikolajev, Ari Waisman, Christoph Garbers, Sebastian Theurich, Jan Mauer, Nadine Hövelmeyer, F Thomas Wunderlich
Colorectal cancer (CRC) is one of the most lethal cancers worldwide in which the vast majority of cases exhibit little genetic risk but are associated with a sedentary lifestyle and obesity. Although the mechanisms underlying CRC and colitis-associated colorectal cancer (CAC) remain unclear, we hypothesised that obesity-induced inflammation predisposes to CAC development. Here, we show that diet-induced obesity accelerates chemically-induced CAC in mice via increased inflammation and immune cell recruitment...
April 25, 2018: Nature Communications
https://www.readbyqxmd.com/read/29694329/correlation-of-platelet-to-lymphocyte-and-neutrophil-to-lymphocyte-ratio-with-hormonal-and-metabolic-parameters-in-women-with-pcos
#10
Vasilios Pergialiotis, Eftihios Trakakis, Christos Parthenis, Erifili Hatziagelaki, Charalampos Chrelias, Nikolaos Thomakos, Nikolaos Papantoniou
Background The purpose of our study is to evaluate the association of platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) with hormonal and metabolic parameters in patients with polycystic ovarian syndrome (PCOS) in order to assess whether these ratios may become useful tools during the evaluation of the severity of low grade inflammation. Methods The present study is based in secondary outcomes from a prospectively collected patient database. A total of 266 women with PCOS participated in this study and blood a complete blood count examination (CBC) that was used for the calculation of PLR and NLR was available in 182 patients...
April 25, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29680668/anti-il-7-receptor-%C3%AE-treatment-ameliorates-newly-established-sj%C3%A3-gren-s-like-exocrinopathy-in-non-obese-diabetic-mice
#11
Jing Zhou, Qing Yu
The levels of interleukin (IL)-7 and its receptor are elevated in the salivary glands of patients with Sjögren's syndrome (SS). Our previous study indicates that IL-7 plays a critical pathogenic role in the development and onset of SS in a mouse model of this disease. The present study aims at determining whether IL-7 also plays a role in sustaining SS pathologies after the disease onset, by using the non-obese diabetic (NOD) model. Intraperitoneal administration of a blocking antibody against the IL-7 receptor α chain (IL-7Rα) to female NOD mice aged 10 weeks, which exhibited newly onset clinical SS, for the duration of 3 weeks significantly ameliorated characteristic SS pathologies including hyposalivation and leukocyte infiltration of the submandibular glands (SMGs)...
April 19, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29673675/the-association-between-in-vitro-fertilization-outcome-and-the-inflammatory-markers-of-complete-blood-count-among-nonobese-unexplained-infertile-couples
#12
Esra Nur Tola
OBJECTIVE(S): The purpose of our study was to evaluate whether the inflammatory parameters of complete blood count (CBC), including white blood cell (WBC), neutrophil-to-lymphocyte-ratio (NLR), platelet-to-lymphocyte-ratio (PLR), and mean platelet volume (MPV), had potential roles in the etiopathogenesis of unexplained infertility (UI) among nonobese women. We also aimed to investigate whether there could be an association between these markers and in vitro fertilization (IVF) success among nonobese women with UI...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29576354/aged-garlic-extract-supplementation-modifies-inflammation-and-immunity-of-adults-with-obesity-a-randomized-double-blind-placebo-controlled-clinical-trial
#13
Changjie Xu, Anne E Mathews, Camila Rodrigues, Brandon J Eudy, Cheryl A Rowe, Alison O'Donoughue, Susan S Percival
BACKGROUND: Obesity is a serious global health issue and often results in low-grade systemic inflammation, increasing the risk for several chronic diseases. If obesity-induced inflammation could be reduced, fewer complications and co-morbidities might occur. OBJECTIVE: To investigate whether daily supplementation with aged garlic extract (AGE) could reduce chronic inflammation and improve immune function in adults with obesity. METHODS: Fifty-one healthy adults with obesity (mean age 45...
April 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29560551/impaired-natural-killer-cell-subset-phenotypes-in-human-obesity
#14
Ina Bähr, Janine Jahn, Alexander Zipprich, Inge Pahlow, Julia Spielmann, Heike Kielstein
Obesity is associated with alterations in functionality of immune cells, like macrophages and natural killer (NK) cells, leading to an increased risk for severe infections and several cancer types. This study aimed to examine immune cell populations and functional NK cell parameters focusing on NK cell subset phenotypes in normal-weight and obese humans. Therefore, peripheral blood mononuclear cells (PBMCs) were isolated from normal-weight and obese individuals and analyzed by flow cytometry. Results show no significant changes in the frequency of monocytes, B lymphocytes, or NKT cells but a significantly increased frequency of T lymphocytes in obesity...
March 20, 2018: Immunologic Research
https://www.readbyqxmd.com/read/29559978/human-body-composition-and-immunity-visceral-adipose-tissue-produces-il-15-and-muscle-strength-inversely-correlates-with-nk-cell-function-in-elderly-humans
#15
Ahmad Al-Attar, Steven R Presnell, Jody L Clasey, Douglas E Long, R Grace Walton, Morgan Sexton, Marlene E Starr, Philip A Kern, Charlotte A Peterson, Charles T Lutz
Natural killer (NK) lymphocyte-mediated cytotoxicity and cytokine secretion control infections and cancers, but these crucial activities decline with age. NK cell development, homeostasis, and function require IL-15 and its chaperone, IL-15 receptor alpha (IL-15Rα). Macrophages and dendritic cells (DC) are major sources of these proteins. We had previously postulated that additional IL-15 and IL-15Rα is made by skeletal muscle and adipose tissue. These sources may be important in aging, when IL-15-producing immune cells decline...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29520270/a-novel-role-for-c5a-in-b-1-cell-homeostasis
#16
Katharina Bröker, Julia Figge, Albert F Magnusen, Rudolf A Manz, Jörg Köhl, Christian M Karsten
B-1 cells constitute a unique subpopulation of lymphocytes residing mainly in body cavities like the peritoneal cavity (PerC) but are also found in spleen and bone marrow (BM). As innate-like B cells, they mediate first line immune defense through low-affinity natural IgM (nIgM) antibodies. PerC B-1 cells can egress to the spleen and differentiate into nIgM antibody-secreting plasma cells that recognize conserved exogenous and endogenous cellular structures. Homing to and homeostasis within the PerC are regulated by the chemokine CXCL13 released by PerC macrophages and stroma cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29519750/de-novo-hdac8-mutation-causes-rett-related-disorder-with-distinctive-facial-features-and-multiple-congenital-anomalies
#17
Tomoko Saikusa, Munetsugu Hara, Kazuhiro Iwama, Kotaro Yuge, Chihiro Ohba, Jun-Ichiro Okada, Tadashi Hisano, Yushiro Yamashita, Nobuhiko Okamoto, Hirotomo Saitsu, Naomichi Matsumoto, Toyojiro Matsuishi
We present a unique 11-year-old girl showing clinical features of Rett-related disorder with distinctive facial features and multiple congenital anomalies including ocular hypertelorism, arched eyebrows, a broad nose, dental anomalies, congenital heart disease, truncal obesity, and epilepsy. A novel de novo mutation in histone deacetylase 8 (HDAC8) (c.652G > T, p.Gly218Cys) was confirmed by whole exome sequencing and Sanger sequencing. X-chromosome inactivation analysis on DNA isolated from peripheral blood lymphocytes revealed a completely skewed pattern associated with an inactive maternal allele...
May 2018: Brain & Development
https://www.readbyqxmd.com/read/29515042/cd8-t-cells-in-beige-adipogenesis-and-energy-homeostasis
#18
Maria Moysidou, Sevasti Karaliota, Elisavet Kodela, Maria Salagianni, Yassemi Koutmani, Antonia Katsouda, Konstantia Kodella, Panagiotis Tsakanikas, Styliani Ourailidou, Evangelos Andreakos, Nikolaos Kostomitsopoulos, Dimitris Skokos, Antonios Chatzigeorgiou, Kyoung-Jin Chung, Stefan Bornstein, Mark W Sleeman, Triantafyllos Chavakis, Katia P Karalis
Although accumulation of lymphocytes in the white adipose tissue (WAT) in obesity is linked to insulin resistance, it remains unclear whether lymphocytes also participate in the regulation of energy homeostasis in the WAT. Here, we demonstrate enhanced energy dissipation in Rag1-/- mice, increased catecholaminergic input to subcutaneous WAT, and significant beige adipogenesis. Adoptive transfer experiments demonstrated that CD8+ T cell deficiency accounts for the enhanced beige adipogenesis in Rag1-/- mice...
March 8, 2018: JCI Insight
https://www.readbyqxmd.com/read/29496744/loss-of-ocab-prevents-age-induced-fat-accretion-and-insulin-resistance-by-altering-b-lymphocyte-transition-and-promoting-energy-expenditure
#19
Sophie Carter, Stéphanie Miard, Alexandre Caron, Sandrine Sallé-Lefort, Philippe St-Pierre, Fernando Forato Anhê, Emilie Lavoie-Charland, Pascale Blais-Lecours, Marie-Claude Drolet, Julie S Lefebvre, Julie Lacombe, Yves Deshaies, Jacques Couet, Mathieu Laplante, Mathieu Ferron, Yohan Bossé, André Marette, Denis Richard, David Marsolais, Frédéric Picard
The current demographic shift toward an aging population has led to a robust increase in the prevalence of age-associated metabolic disorders. Interestingly, recent studies have demonstrated that the etiology of obesity-related insulin resistance developed upon aging differs from that induced by high-calorie diets. Whereas the role of adaptive immunity on the changes in energy metabolism driven by nutritional challenges has gained attention in the past years, its impact upon aging remains mostly unknown. Here, we found that follicular B2 lymphocytes and expression levels of the B cell-specific transcriptional coactivator OcaB increase with age in spleen and in intra-abdominal epididymal white adipose tissue (eWAT), concomitantly with higher circulating levels of immunoglobulin G (IgG) and impaired glucose homeostasis...
March 1, 2018: Diabetes
https://www.readbyqxmd.com/read/29482037/biology-and-function-of-adipose-tissue-macrophages-dendritic-cells-and-b-cells
#20
REVIEW
Stoyan Ivanov, Johanna Merlin, Man Kit Sam Lee, Andrew J Murphy, Rodolphe R Guinamard
The increasing incidence of obesity and its socio-economical impact is a global health issue due to its associated co-morbidities, namely diabetes and cardiovascular disease [1-5]. Obesity is characterized by an increase in adipose tissue, which promotes the recruitment of immune cells resulting in low-grade inflammation and dysfunctional metabolism. Macrophages are the most abundant immune cells in the adipose tissue of mice and humans. The adipose tissue also contains other myeloid cells (dendritic cells (DC) and neutrophils) and to a lesser extent lymphocyte populations, including T cells, B cells, Natural Killer (NK) and Natural Killer T (NKT) cells...
April 2018: Atherosclerosis
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