keyword
MENU ▼
Read by QxMD icon Read
search

obesity lymphocyte

keyword
https://www.readbyqxmd.com/read/28714549/increased-level-of-dna-damage-in-some-organs-of-obese-zucker-rats-by-%C3%AE-h2ax-analysis
#1
Alessia Azzarà, Anna Chiaramonte, Erika Filomeni, Barbara Pinto, Stefano Mazzoni, Simona Piaggi, Maria Angela Guzzardi, Fabrizio Bruschi, Patricia Iozzo, Roberto Scarpato
In a recent study, we showed that lymphocytes of obese Italian children/adolescents displayed levels of double strand breaks (DSB), assayed as serine 139-phosphorylated histone H2AX (γ-H2AX), about eightfold higher than normal weight controls, and that 30% of this damage-generated micronuclei. These findings suggested that obese children could be at increased risk of obesity-mediated cancer later in life. We therefore aimed to assess the level of γ-H2AX in a genetic animal model of obesity (Zucker rat) to identify a genotoxic/carcinogenic risk in some organs...
July 17, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/28711285/anti-il-21-monoclonal-antibody-combined-with-liraglutide-effectively-reverses-established-hyperglycemia-in-mouse-models-of-type-1-diabetes
#2
Anna K Rydén, Nikole R Perdue, Philippe P Pagni, Claire B Gibson, Sowbarnika S Ratliff, Rikke K Kirk, Travis J Friesen, Claus Haase, Ken Coppieters, Matthias G von Herrath, Tamar E Boursalian
Immunotherapy for type 1 diabetes (T1D) has previously focused on suppressing the autoimmune response against pancreatic beta cells to preserve endogenous insulin production and regulate glucose levels. With increased attention toward combination therapy strategies, studies indicate the multifunctional cytokine interleukin-21 (IL-21) may be a suitable target as an immuno-modulatory arm, while glucagon-like peptide-1 receptor (GLP-1R) agonists may be appropriate as a beta cell protective arm in combination therapy for T1D...
July 12, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28707376/immunosenescence-induced-by-plasma-from-individuals-with-obesity-caused-cell-signaling-dysfunction-and-inflammation
#3
Mariana Migliorini Parisi, Lucas Kich Grun, Patrícia Lavandoski, Letícia Biscaino Alves, Ivi Juliana Bristot, Rita Mattiello, Cláudio Corá Mottin, Fábio Klamt, Marcus Herbert Jones, Alexandre Vontobel Padoin, Fátima Costa Rodrigues Guma, Florencia María Barbé-Tuana
OBJECTIVE: To evaluate the consequences of plasma from individuals with obesity on parameters associated with immunosenescence in unrelated healthy peripheral blood mononuclear cells (PBMC). METHODS: Freshly isolated PBMC were incubated in media supplemented with 10% of plasma from individuals with obesity or control subjects for the first 4 hours of 24 to 120 hours of culture. RESULTS: Plasma from individuals with obesity modulated the phenotype of healthy PBMC, leading to a higher rate of apoptosis, lower amounts of phospho-γH2AX and -p53, and mitochondrial dysfunction...
July 14, 2017: Obesity
https://www.readbyqxmd.com/read/28699612/relationship-between-immune-parameters-and-non-alcoholic-fatty-liver-disease-in-obese-children
#4
Jun-Qi Shi, Wen-Xia Shen, Xiang-Zhi Wang, Ke Huang, Chao-Chun Zou
OBJECTIVE: To investigate the relationship between immune parameters and non-alcoholic fatty liver disease (NAFLD) in obese children. DESIGN: Case-control study. SETTING: Zhejiang Province, China on July to September 2015. PARTICIPANTS: A total of 117 obese children and 209 healthy non-obese children were studied as the obese and control groups. Depending on the severity of NAFLD, the obese group was divided into subgroups 1 (without NAFLD), 2 (with simple fatty liver) and 3 (with steatohepatitis)...
July 11, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28696349/the-cell-surface-markers-expression-in-postmenopausal-women-and-relation-to-obesity-and-bone-status
#5
Mira Horváthová, Silvia Ilavská, Kornélia Štefíková, Michaela Szabová, Zora Krivošíková, Eva Jahnová, Jana Tulinská, Viera Spustová, Martin Gajdoš
The age-related changes and hormonal deprivation in postmenopausal women are associated with the immune response alteration. The excessive fat accumulation, local and systemic inflammation may lead to dysregulation in immune function and relevant health problems, including obesity and osteoporosis. We analyzed the expression of cell surface markers in the venous blood specimens, stained with fluorophores-conjugated monoclonal antibodies and analysed by multicolour flow cytometry. The significant changes of cytotoxic, naive, and memory T-lymphocytes, plasmacytoid dendritic cells (DCs) were in postmenopausal women versus fertile women...
July 11, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28690599/gut-dysbiosis-and-adaptive-immune-response-in-diet-induced-obesity-vs-systemic-inflammation
#6
Jana Pindjakova, Claudio Sartini, Oriana Lo Re, Francesca Rappa, Berengere Coupe, Benjamin Lelouvier, Valerio Pazienza, Manlio Vinciguerra
A mutual interplay exists between adaptive immune system and gut microbiota. Altered gut microbial ecosystems are associated with the metabolic syndrome, occurring in most obese individuals. However, it is unknown why 10-25% of obese individuals are metabolically healthy, while normal weight individuals can develop inflammation and atherosclerosis. We modeled these specific metabolic conditions in mice fed with a chow diet, an obesogenic but not inflammatory diet-mimicking healthy obesity, or Paigen diet-mimicking inflammation in the lean subjects...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28684145/glp-1-receptor-agonist-liraglutide-ameliorates-hepatosteatosis-induced-by-anti-cd3-antibody-in-female-mice
#7
Arata Itoh, Junichiro Irie, Hirotsune Tagawa, Yukie Kusumoto, Mari Kato, Nana Kobayashi, Kumiko Tanaka, Rieko Kikuchi, Masataka Fujita, Yuya Nakajima, Yuehong Wu, Satoru Yamada, Toshihide Kawai, William M Ridgway, Hiroshi Itoh
AIMS: Hepatosteatosis is mainly induced by obesity and metabolic disorders, but various medications also induce hepatosteatosis. The administration of anti-CD3 antibody was shown to induce hepatosteatosis, but changes in lipid and glucose metabolism remain unclear. We investigated the mechanism of hepatosteatosis induced by anti-CD3 antibody and the effects of glucagon-like peptide-1 (GLP-1) receptor agonist that was recently shown to affect immune function in metabolic disorders. METHODS: Anti-CD3 antibody was administered to female BALB/c and C...
June 1, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28679588/adipocyte-mtorc1-deficiency-promotes-adipose-tissue-inflammation-and-nlrp3-inflammasome-activation-via-oxidative-stress-and-de-novo-ceramide-synthesis
#8
Patricia Chimin, Maynara L Andrade, Thiago Belchior, Vivian A Paschoal, Juliana Magdalon, Alex S Yamashita, Erique Castro, Angela Castoldi, Adriano B Chaves-Filho, Marcos Y Yoshinaga, Sayuri Miyamoto, Niels O Camara, William T Festuccia
Mechanistic Target of Rapamycin complex 1 (mTORC1) activity is increased in adipose tissue of obese, insulin resistant mice, but its role in the regulation of tissue inflammation is unknown. We investigated herein the effects of adipocyte mTORC1 deficiency on adipose tissue inflammation and glucose homeostasis. For this, mice with adipocyte raptor deletion and controls fed a chow or a high-fat diet were evaluated for body mass, adiposity, glucose homeostasis and adipose tissue inflammation. Despite reducing adiposity, adipocyte mTORC1 deficiency promoted hepatic steatosis, insulin resistance and adipose tissue inflammation (increased infiltration of macrophages, neutrophils and B lymphocytes, crown-like structure density, TNF-α, IL-6 and MCP1 expression, IL-1β protein content, lipid peroxidation and de novo ceramide synthesis)...
July 5, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28649243/distinct-blood-and-visceral-adipose-tissue-regulatory-t-cell-and-innate-lymphocyte-profiles-characterize-obesity-and-colorectal-cancer
#9
Gloria Donninelli, Manuela Del Cornò, Marina Pierdominici, Beatrice Scazzocchio, Rosaria Varì, Barbara Varano, Ilenia Pacella, Silvia Piconese, Vincenzo Barnaba, Massimo D'Archivio, Roberta Masella, Lucia Conti, Sandra Gessani
Visceral adipose tissue (VAT) is a main site where metabolic and immunologic processes interplay to regulate, at local and systemic level, the inflammatory status and immune response. Obesity-associated inflammation and immune dysfunctions are inextricably linked to tumor but, in spite of intense efforts, the mechanisms underpinning this association remain elusive. In this report, we characterized the profile of VAT-associated and circulating innate lymphocyte and regulatory T (Treg) cell subsets underlying inflammatory conditions, such as obesity and colorectal cancer (CRC)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28642328/leukocyte-diversity-in-resolving-and-nonresolving-mechanisms-of-cardiac-remodeling
#10
REVIEW
Bochra Tourki, Ganesh Halade
In response to myocardial infarction (MI), time-dependent leukocyte infiltration is critical to program the acute inflammatory response. Post-MI leukocyte density, residence time in the infarcted area, and exit from the infarcted injury predict resolving or nonresolving inflammation. Overactive or unresolved inflammation is the primary determinant in heart failure pathology post-MI. Here, our review describes supporting evidence that the acute inflammatory response also guides the generation of healing and regenerative mediators after cardiac damage...
June 22, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28630652/verification-of-b-lymphocyte-activating-factor-s-involvement-in-the-exacerbation-of-insulin-resistance-as-well-as-an-autoimmune-response-in-patients-with-nonalcoholic-steatohepatitis-and-patients-with-hcv-related-chronic-liver-disease
#11
Takashi Himoto, Koji Fujita, Takako Nomura, Joji Tani, Asahiro Morishita, Hirohito Yoneyama, Reiji Haba, Tsutomu Masaki
BACKGROUND: Ten to forty percent of nonalcoholic steatohepatitis (NASH) and HCV-related chronic liver disease (CLD-C) patients have antinuclear antibodies (ANAs). However, the relationship between autoimmune response and insulin resistance remains uncertain among those patients. The primary purpose of this study was to investigate whether or not ANA status was associated with the development of insulin resistance and obesity in NASH and CLD-C patients. METHODS: Degrees of hepatic fibrosis and steatosis were evaluated by the classification proposed by Brunt et al...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28619429/vitamin-d-and-multiple-sclerosis-an-update
#12
REVIEW
Charles Pierrot-Deseilligny, Jean-Claude Souberbielle
The most recent findings linking exposure to sun and vitamin D insufficiency to multiple sclerosis (MS) are reviewed. Due to insufficient sunshine and changing lifestyles, hypovitaminosis D is widespread in temperate countries. Numerous epidemiological studies have strongly suggested that sunshine and vitamin D insufficiency contributes to MS risk in these countries. Moreover, several large genetic studies in MS patients have recently stated unequivocally that diverse abnormalities involving vitamin D metabolism are related to the risk of the disease...
May 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28618839/sphingosine-kinase-and-sphingosine-1-phosphate-in-liver-pathobiology
#13
Timothy Rohrbach, Michael Maceyka, Sarah Spiegel
Over 20 years ago, sphingosine-1-phosphate (S1P) was discovered to be a bioactive signaling molecule. Subsequent studies later identified two related kinases, sphingosine kinase 1 and 2, which are responsible for the phosphorylation of sphingosine to S1P. Many stimuli increase sphingosine kinase activity and S1P production and secretion. Outside the cell, S1P can bind to and activate five S1P-specific G protein-coupled receptors (S1PR1-5) to regulate many important cellular and physiological processes in an autocrine or paracrine manner...
June 15, 2017: Critical Reviews in Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28615667/il-6-secretion-in-osteoarthritis-patients-is-mediated-by-chondrocyte-synovial-fibroblast-cross-talk-and-is-enhanced-by-obesity
#14
Mark J Pearson, Dietmar Herndler-Brandstetter, Mohammad A Tariq, Thomas A Nicholson, Ashleigh M Philp, Hannah L Smith, Edward T Davis, Simon W Jones, Janet M Lord
Increasing evidence suggests that inflammation plays a central role in driving joint pathology in certain patients with osteoarthritis (OA). Since many patients with OA are obese and increased adiposity is associated with chronic inflammation, we investigated whether obese patients with hip OA exhibited differential pro-inflammatory cytokine signalling and peripheral and local lymphocyte populations, compared to normal weight hip OA patients. No differences in either peripheral blood or local lymphocyte populations were found between obese and normal-weight hip OA patients...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28611026/map4k4-impairs-energy-metabolism-in-endothelial-cells-and-promotes-insulin-resistance-in-obesity
#15
Rachel J Roth Flach, Marina T DiStefano, Laura V Danai, Ozlem Senol-Cosar, Joseph C Yawe, Mark Kelly, Lorena Garcia Menendez, Michael P Czech
The blood vasculature responds to insulin, influencing hemodynamic changes in the periphery, which promotes tissue nutrient and oxygen delivery and thus metabolic function. The lymphatic vasculature regulates fluid and lipid homeostasis, and impaired lymphatic function can contribute to atherosclerosis and obesity. Recent studies have suggested a role for endothelial cell (EC) Mitogen activated protein kinase kinase kinase kinase 4 (Map4k4) in developmental angiogenesis and lymphangiogenesis as well as atherosclerosis...
June 13, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28583511/blood-count-values-and-ratios-for-predicting-sleep-apnea-in-obese-children
#16
Ibrahim Erdim, Omer Erdur, Fatih Oghan, Fatih Mete, Mustafa Celik
OBJECTIVES: To detect whether the mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are contributing factors in the diagnosis and severity of sleep apnea in obese children. INTRODUCTION: Obesity is a public health problem, and its prevalence increases daily. Although PSG is the gold standard test in the investigation of sleep apnea, the application of this test requires equipment, personnel, time, and cost. There is no simple laboratory test for diagnosing and determining the severity of sleep apnea...
July 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28559653/clinical-characteristics-of-patients-less-than-forty-years-old-with-coronary-artery-disease-in-taiwan-a-cross-sectional-study
#17
Wei-Che Tsai, Keng-Yi Wu, Gen-Min Lin, Sy-Jou Chen, Wei-Shiang Lin, Shih-Ping Yang, Shu-Meng Cheng, Chin-Sheng Lin
BACKGROUND: Coronary artery disease (CAD) rarely occurs in young adults. Our objective was to investigate the baseline characteristics and outcomes of young patients with CAD. METHODS: We retrospectively enrolled patients aged < 40 years of age who underwent coronary angiography in a tertiary hospital in Taiwan between 2002 and 2015. The baseline characteristics and in-hospital outcomes of patients with acute coronary syndrome (ACS) and occlusive CAD (stenotic lesions > 50%) were compared with those of patients without ACS and non-occlusive CAD, respectively...
May 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28535403/the-predictive-effect-of-inflammatory-markers-and-lipid-accumulation-product-index-on-clinical-symptoms-associated-with-polycystic-ovary-syndrome-in-nonobese-adolescents-and-younger-aged-women
#18
Esra Nur Tola, Serenat Eris Yalcin, Nadiye Dugan
OBJECTIVE(S): The aim of our study is to analyse the inflammatory markers and lipid accumulation product (LAP) index in nonobese adolescents and younger aged women with polycystic ovary syndrome (PCOS) compared with age and body mass index (BMI)-matched healthy controls and to determine whether the investigated parameters are potential markers for the etiopathogenesis of PCOS. We also aim to determine whether these inflammatory markers are predictive for developing some clinical implications, such as cardiovascular disease (CVD) and insulin resistance (IR), associated with PCOS...
July 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28500380/association-of-t-lymphocyte-immune-imbalance-and-il-10-gene-polymorphism-with-the-risk-of-obstructive-sleep-apnea-in-children-with-obesity
#19
Miao-Shang Su, Li Xu, Kang Xu, Ji-Shan Zheng
PURPOSE: The purpose of this study is to determine the role of T lymphocyte immune imbalance and interleukin (IL)-10 gene polymorphism in the development of obstructive sleep apnea (OSA) in obese children. METHODS: One hundred obese children at high-risk and low-risk for OSA based upon a sleep questionnaire were selected. Peripheral blood T lymphocyte subsets were measured by flow cytometry, and plasma IFN-γ, IL-4, and IL-10 cytokines were detected by ELISA. The relationships between OSA and the above variables were analyzed...
May 12, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28491871/the-imbalance-of-b-lymphocyte-subsets-in-subjects-with-different-glucose-tolerance-relationship-with-metabolic-parameter-and-disease-status
#20
Chao Deng, Yufei Xiang, Tingting Tan, Zhihui Ren, Chuqing Cao, Bingwen Liu, Gan Huang, Xiangbing Wang, Zhiguang Zhou
B lymphocytes are involved in inflammation and are related to insulin resistance in obesity and type 2 diabetes (T2D). This study investigated the phenotype and frequency of B-lymphocyte subsets in subjects recently diagnosed with T2D (n = 60), impaired glucose regulation (IGR, n = 73), and normal glucose tolerance (NGT, n = 169) by flow cytometry. T2D subjects had an increased percentage of CD19(+)CD23(+) (B-2) cells and a decreased percentage of CD19(+)CD23(-) (B-1) cells attributing to CD19(+)CD23(-)CD5(-) (B-1b) cells, but not CD19(+)CD23(-)CD5(+) (B-1a) cells, compared to NGT and IGR subjects...
2017: Journal of Diabetes Research
keyword
keyword
110681
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"