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https://www.readbyqxmd.com/read/28925409/metabolic-and-genomic-adaptations-to-winter-fattening-in-a-primate-species-the-grey-mouse-lemur-microcebus-murinus
#1
J Terrien, M Gaudubois, D Champeval, V Zaninotto, L Roger, J F Riou, F Aujard
AIM: To understand the mechanisms underlying the development of metabolic changes leading to obesity remains a major world health issue. Among such mechanisms, seasonality is quite underestimated although it corresponds to the manifestation of extreme metabolic flexibility in response to a changing environment. Nevertheless, the changes induced by such flexibility are far to be understood, especially at the level of insulin signaling, genomic stability or inflammation. METHODS: Here, we investigated the metabolic regulations displayed by a seasonal primate species, the grey mouse lemur (Microcebus murinus) that exhibits pronounced changes in body mass during the 6-month winter season: a fattening period followed by a spontaneous fat loss, without ever reaching pathological stages...
August 14, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28923316/different-combinations-of-maternal-and-postnatal-diet-are-reflected-in-changes-of-hepatic-parenchyma-and-hepatic-tnf-alpha-expression-in-male-rat-offspring
#2
Željka Perić Kačarević, Anđela Grgić, Darija Šnajder, Nikola Bijelić, Tatjana Belovari, Olga Cvijanović, Valerija Blažičević, Radivoje Radić
Obesity is related to increased TNF-alpha production in different tissues. TNF-alpha is connected to mitochondrial dysfunction in the liver and also development of fatty infiltration of the liver. Also, postnatal change from normal to high-fat diet causes a significant increase in TNF-alpha serum levels. The aim of this research was to determine how maternal diet and switching male offspring to a different dietary regime after lactation influences rat liver. Ten female Sprague Dawley rats at nine weeks of age were randomly divided in two groups and fed either standard laboratory chow or high-fat diet during six weeks, and then mated with the same male subject...
September 15, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28917996/poor-efficacy-of-tnf-inhibitors-in-non-radiographic-axial-spondyloarthritis-in-the-absence-of-objective-signs-a-bicentric-retrospective-study
#3
Céline Vidal, Cédric Lukas, Bernard Combe, Francis Berenbaum, Yves Marie Pers, Christian Jorgensen, Jérémie Sellam, Jacques Morel
OBJECTIVE: To compare BASDAI 50 response rate to TNFi in axial spondyloarthritis (axSpA) depending on the presence or not of objective signs of axSpA and to look for predictive factors of TNFi efficacy. METHODS: Patients diagnosed with axSpA according to ASAS criteria "clinical arm" and treated between January 2001 and September 2015 with TNFi were included. First group included patients with at least one objective sign such as arthritis, dactylitis, enthesitis, uveitis, inflammatory bowel disease, elevated C-reactive protein or radiological sacroiliitis, and second group included non-radiographic axSpA (nr-axSpA) patients without any objective sign corresponding to patients with inflammatory back pain and either a good response to NSAID or a SpA family history...
September 13, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28911649/long-chain-bases-from-sea-cucumber-mitigate-endoplasmic-reticulum-stress-and-inflammation-in-obesity-mice
#4
Shiwei Hu, Jinhui Wang, Jingfeng Wang, Changhu Xue, Yuming Wang
Endoplasmic reticulum (ER) stress and inflammation can induce hyperglycemia. Long-chain bases (LCBs) from sea cucumber exhibit antihyperglycemic activities. However, their effects on ER stress and inflammation are unknown. We investigated the effects of LCBs on ER stress and inflammatory response in high-fat, fructose diet-induced obesity mice. Reactive oxygen species and free fatty acids were measured. Inflammatory cytokines in serum and their mRNA expressions in epididymal adipose tissues were investigated...
July 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28904916/prevalence-of-metabolic-syndrome-in-psoriasis-and-levels-of-interleukin-6-and-tumor-necrosis-factor-%C3%AE-in-psoriasis-patients-with-metabolic-syndrome-indian-tertiary-care-hospital-study
#5
Surjit Singh, Sunil Dogra, Nusrat Shafiq, Anil Bhansali, Samir Malhotra
BACKGROUND: Psoriasis is a chronic inflammatory multisystem disease, found to be associated with metabolic syndrome (MS) and increased levels of cytokines. To evaluate the prevalence of MS in psoriasis and to determine the levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in psoriasis patients with MS. METHODS: Observational study on 334 psoriasis patients and 230 controls. MS was diagnosed by the presence of three or more criteria of original, revised, and modified National Cholesterol Education Program's Adult Treatment Panel III (NCEP ATP III)...
July 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28903160/safety-of-systemic-agents-for-the-treatment-of-pediatric-psoriasis
#6
Inge M G J Bronckers, Marieke M B Seyger, Dennis P West, Irene Lara-Corrales, Megha Tollefson, Wynnis L Tom, Marcia Hogeling, Leah Belazarian, Claus Zachariae, Emmanuel Mahé, Elaine Siegfried, Sandra Philipp, Zsuzsanna Szalai, Ruth Ann Vleugels, Kristen Holland, Ruth Murphy, Eulalia Baselga, Kelly Cordoro, Jo Lambert, Alex Alexopoulos, Ulrich Mrowietz, Wietske Kievit, Amy S Paller
Importance: Use of systemic therapies for moderate to severe psoriasis in children is increasing, but comparative data on their use and toxicities are limited. Objective: To assess patterns of use and relative risks of systemic agents for moderate to severe psoriasis in children. Design, Setting, and Participants: A retrospective review was conducted at 20 centers in North America and Europe, and included all consecutive children with moderate to severe psoriasis who used systemic medications or phototherapy for at least 3 months from December 1, 1990, to September 16, 2014...
September 13, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28902432/c1q-tnf-related-protein-9-improves-the-anti-contractile-effects-of-perivascular-adipose-tissue-via-the-ampk-enos-pathway-in-diet-induced-obese-mice
#7
Fang Han, Yang Zhang, Mingxia Shao, Qingjie Mu, Xiaotong Jiao, Ningning Hou, Xiaodong Sun
The anti-contractile property of perivascular adipose tissue (PVAT) is abolished through an endothelium-dependent pathway in obesity. C1q/tumor necrosis factor-related protein (CTRP)9 improved endothelial function by promoting endothelium-dependent vasodilatation. The aims of this study were to investigate whether CTRP9 improves the anti-contractile effect of PVAT and protects against PVAT dysfunction in obese mice. The mice were treated with a high-fat diet with or without CTRP9 treatment. Thoracic aortas with or without PVAT (PVAT+ or PVAT-) were prepared, and concentration-dependent responses to phenylephrine were measured...
September 13, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28901460/tumor-necrosis-factor%C3%A2-%C3%AE-and-interleukin%C3%A2-6-suppress-microrna%C3%A2-1275-transcription-in-human-adipocytes-through-nuclear-factor%C3%A2-%C3%AE%C2%BAb
#8
Yu-Feng Zhou, Zi-Yi Fu, Xiao-Hui Chen, Yan Cui, Chen-Bo Ji, Xi-Rong Guo
Obesity is a confirmed risk factor for hyperlipidemia, type‑II diabetes, hypertension, and cardiovascular disease. MicroRNAs (miRs) have emerged as an important field of study within energy metabolism and obesity. A previous study demonstrated miR‑1275 to be markedly down‑regulated during maturation of human preadipocytes. It has been reported that miR‑1275 dysregulates expression in several types of cancer and infections. Little is currently known about the regulation of miR‑1275 transcription. The aim of the current study was to explore the mechanism underlying the expression of miR‑1275 in mature human adipocytes...
August 29, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28895012/biologic-agents-are-associated-with-excessive-weight-gain-in-children-with-inflammatory-bowel-disease
#9
Leonard Haas, Rachel Chevalier, Brittny T Major, Felicity Enders, Seema Kumar, Jeanne Tung
BACKGROUND: Children with active inflammatory bowel disease (IBD) are frequently underweight. Anti-tumor necrosis factor (anti-TNF) agents may induce remission and restore growth. However, its use in other autoimmune diseases has been associated with excess weight gain. Our aim was to examine whether children with IBD could experience excess weight gain. METHODS: A centralized diagnostic index identified pediatric IBD patients evaluated at our institution who received anti-TNF therapy for at least 1 year between August 1998 and December 2013...
September 11, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28894050/compounds-of-psoriasis-with-obesity-and-overweight
#10
Agnieszka Owczarczyk-Saczonek, Waldemar Placek
Many epidemiological studies have confirmed the relationship of obesity and psoriasis, and it is believed that obesity is an independent risk factor for its development and is associated with a worse prognosis. Furthermore, the reduction of body weight, using low-calorie diet combined with exercise, reduces the severity of psoriasis.Visceral adipose tissue is the largest endocrine organ, producing proinflammatory cytokines (TNF-α, IL-6, IL-17) and adipokines (adiponectin, omentin, chemerin). They participate in the development of dyslipidemia, insulin resistance, diabetes, and consequently of the cardiovascular diseases...
August 24, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28892456/nobiletin-attenuates-the-inflammatory-response-through-heme-oxygenase-1-induction-in-the-crosstalk-between-adipocytes-and-macrophages
#11
Seulgi Namkoong, Jeehye Sung, Jinwoo Yang, Youngmin Choi, Heon Sang Jeong, Junsoo Lee
Crosstalk between adipocytes and macrophages has been suggested to play a crucial role in metabolic disorders such as obesity, insulin resistance, and type 2 diabetes. The objective of this study was to evaluate the effect of nobiletin on the interaction between adipocytes and macrophages. The results showed that nobiletin significantly and dose-dependently inhibited the secretion of inflammatory mediators, such as nitric oxide (NO), tumor necrosis factor (TNF-α), and monocyte chemoattractant protein (MCP)-1, in a coculture of adipocytes and macrophages...
September 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28891395/effects-of-catechins-and-caffeine-on-the-development-of-atherosclerosis-in-mice
#12
Litong Liu, Izumi Nagai, Ying Gao, Yoshibumi Matsushima, Yoshichika Kawai, Kazutoshi Sayama
Atherosclerosis is one of the diseases related to metabolic syndrome which is caused by obesity. Previous reports have shown that green tea and its components have anti-obesity effect. We examined whether catechins and caffeine can prevent the development of atherosclerosis by oral administration, singly or in combination to the atherosclerosis model mice. Results demonstrated that the number of atherosclerotic regions in the aorta was significantly reduced by the combined treatment, and the atherosclerotic area was also improved...
September 11, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28890700/dietary-capsaicin-improves-glucose-homeostasis-and-alters-the-gut-microbiota-in-obese-diabetic-ob-ob-mice
#13
Jun-Xian Song, Hui Ren, Yuan-Feng Gao, Chong-You Lee, Su-Fang Li, Feng Zhang, Long Li, Hong Chen
Background: The effects of capsaicin on obesity and glucose homeostasis are still controversial and the mechanisms underlying these effects remain largely unknown. This study aimed to investigate the potential relationship between the regulation of obesity and glucose homeostasis by dietary capsaicin and the alterations of gut microbiota in obese diabetic ob/ob mice. Methods: The ob/ob mice were subjected to a normal, low-capsaicin (0.01%), or high-capsaicin (0.02%) diet for 6 weeks, respectively. Obesity phenotypes, glucose homeostasis, the gut microbiota structure and composition, short-chain fatty acids, gastrointestinal hormones, and pro-inflammatory cytokines were measured...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28889804/metabolic-and-inflammatory-markers-associations-with-individual-depressive-symptoms
#14
F Lamers, Y Milaneschi, P de Jonge, E J Giltay, B W J H Penninx
BACKGROUND: Literature has shown that obesity, metabolic syndrome and inflammation are associated with depression, however, evidence suggests that these associations are specific to atypical depression. Which of the atypical symptoms are driving associations with obesity-related outcomes and inflammation is unknown. We evaluated associations between individual symptoms of depression (both atypical and non-atypical) and body mass index (BMI), metabolic syndrome components and inflammatory markers...
September 11, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28889199/oral-delivery-of-staphylococcal-nuclease-by-lactococcus-lactis-prevents-type-1-diabetes-mellitus-in-nod-mice
#15
Junchao Lang, Xiaoke Wang, Kunfeng Liu, Dongmei He, Pancong Niu, Rongyue Cao, Liang Jin, Jie Wu
Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the self-destruction of insulin-producing β cells. Recently, studies have revealed that neutrophils contribute to the early pathological injury to the pancreas, predominantly via the formation of neutrophil extracellular traps (NETs). To determine whether early intervention targeting NETs with staphylococcal nuclease (SNase) can delay the onset of T1DM, non-obese diabetic (NOD) mice were orally administered recombinant Lactococcus lactis (L...
September 9, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28889156/oxidative-damage-and-associated-inflammatory-risk-factors-in-obese-emirati-women-body-mass-index-versus-waist-circumference
#16
Salah Gariballa, Juma Alkaabi, Javed Yasin, Awad Al Essa
OBJECTIVES: To establish whether body mass index (BMI) or waist circumference (WC) is a better predictor of cardio metabolic risk factors that are associated with increased visceral fat among obese women from the United Arab Emirates (UAE). METHODS: In this  cross-sectional study, 333 obese subjects visiting community health centers in Al Ain city, UAE, were recruited between 2012 and 2015. After a written consent subjects had anthropometric, clinical and biochemical measurements...
September 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28888461/a-high-fat-high-sucrose-diet-enriched-in-blue-mussels-protects-against-systemic-inflammation-metabolic-dysregulation-and-weight-gain-in-c57bl-6-mice
#17
Hitesh B Vaidya, Surendiran Gangadaran, Sukhinder K Cheema
High fat-high sucrose (HF-HS) diet, known as the western diet, has been shown to induce the onset of obesity via increasing metabolic inflammation, insulin resistance and adipose tissue dysfunction. Hyperleptinemia, hyperglycemia and dyslipidemia are also the primary observations of obesogenic diet induced obesity. We have previously reported anti-adipogenic and insulin sensitizing effects of blue mussels (BM) using 3T3-L1 cells. BM is a rich source of omega-3 polyunsaturated fatty acids, phytosterols and other micronutrients that has been shown to elicit benefits under obese conditions using in-vitro cell culture models...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28887432/maternal-pregravid-obesity-remodels-the-dna-methylation-landscape-of-cord-blood-monocytes-disrupting-their-inflammatory-program
#18
Suhas Sureshchandra, Randall M Wilson, Maham Rais, Nicole E Marshall, Jonathan Q Purnell, Kent L Thornburg, Ilhem Messaoudi
Prepregnancy maternal obesity is associated with adverse outcomes for the offspring, including increased incidence of neonatal bacterial sepsis and necrotizing enterocolitis. We recently reported that umbilical cord blood (UCB) monocytes from babies born to obese mothers generate a reduced IL-6/TNF-α response to TLR 1/2 and 4 ligands compared to those collected from lean mothers. These observations suggest altered development of the offspring's immune system, which in turn results in dysregulated function...
September 8, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28887124/impaired-insulin-signaling-upon-loss-of-ovarian-function-is-associated-with-a-reduction-of-tristetraprolin-and-an-increased-stabilization-of-chemokine-in-adipose-tissue
#19
Eun-Kyung Choi, Monisha Rajasekaran, Ok-Joo Sul, Yeonsoo Joe, Hyun-Taeg Chung, Rina Yu, Hye-Seon Choi
Loss of ovarian function can activate inflammation and lead to insulin resistance (IR). IR is also a core feature of obesity and obesity-associated metabolic dysfunction. Tristetraprolin/zinc finger protein 36 (TTP) interferes with TNF-α production by destabilizing TNF-α mRNA, and mice deficient in TTP develop a complex syndrome of inflammatory disease (Carballo et al., 1998; Taylor et al., 1999). We hypothesized that ovariectomy (OVX) might also prime inflammation by reducing tristetraprolin/zinc finger protein 36 (TTP) levels...
September 5, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28883756/sodium-butyrate-has-context-dependent-actions-on-dipeptidyl-peptidase-4-and-other-metabolic-parameters
#20
Eun-Sol Lee, Dong-Sung Lee, Prakash Raj Pandeya, Youn-Chul Kim, Dae-Gil Kang, Ho-Sub Lee, Byung-Chul Oh, Dae Ho Lee
Sodium butyrate (SB) has various metabolic actions. However, its effect on dipeptidyl peptidase 4 (DPP-4) needs to be studied further. We aimed to evaluate the metabolic actions of SB, considering its physiologically relevant concentration. We evaluated the effect of SB on regulation of DPP-4 and its other metabolic actions, both in vitro (HepG2 cells and mouse mesangial cells) and in vivo (high fat diet [HFD]-induced obese mice). Ten-week HFD-induced obese C57BL/6J mice were subjected to SB treatment by adding SB to HFD which was maintained for an additional 16 weeks...
September 2017: Korean Journal of Physiology & Pharmacology
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