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https://www.readbyqxmd.com/read/28513622/human-milk-insulin-is-related-to-maternal-plasma-insulin-and-bmi-but-other-components-of-human-milk-do-not-differ-by-bmi
#1
B E Young, Z Patinkin, C Palmer, B de la Houssaye, L A Barbour, T Hernandez, J E Friedman, N F Krebs
BACKGROUND/OBJECTIVES: The impact of maternal BMI and insulin sensitivity on bioactive components of human milk (HM) is not well understood. As the prevalence of obesity and diabetes rises, it is increasingly critical that we understand how maternal BMI and hormones associated with metabolic disease relate to concentrations of bioactive components in HM. SUBJECTS/METHODS: This longitudinal cohort design followed 48 breastfeeding mothers through the first four months of lactation, collecting fasting morning HM samples at 2-weeks and 1, 2, 3 and 4-months, and fasting maternal blood at 2-weeks and 4-months...
May 17, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28508444/increased-adipose-tissue-expression-of-il-18r-and-its-ligand-il-18-associates-with-inflammation-and-insulin-resistance-in-obesity
#2
Rasheed Ahmad, Reeby Thomas, Shihab Kochumon, Sardar Sindhu
INTRODUCTION: The proinflammatory cytokine IL-18 is involved in the pathogenesis of metabolic syndrome. While the changes in IL-18 are known, IL-18R expression and relationship with IL-18 and other inflammatory markers in the adipose tissue in obesity/type-2 diabetes (T2D) remain unclear. METHODS: We, therefore, determined the adipose tissue expression of IL-18R and IL-18 mRNA/protein in lean, overweight, and obese individuals with and without T2D, 15 each, using qRT-PCR, immunohistochemistry, and confocal microscopy...
May 15, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28508193/neutrophil-depletion-improves-diet-induced-non-alcoholic-fatty-liver-disease-in-mice
#3
Rongying Ou, Jia Liu, Mingfen Lv, Jingying Wang, Jinmeng Wang, Li Zhu, Liang Zhao, Yunsheng Xu
PURPOSE: Non-alcoholic fatty liver disease is highly associated with morbidity and mortality in population. Although studies have already demonstrated that the immune response plays a pivotal role in the development of non-alcoholic fatty liver disease, the comprehensive regulation is unclear. Therefore, present study was carried out to investigate the non-alcoholic fatty liver disease development under neutrophil depletion. METHODS: To achieve the aim of the study, C57BL/6 J mice were fed with high fat diet for 6 weeks before treated with neutrophil deplete antibody 1A8 or isotype control (200 μg/ mouse every week) for another 4 weeks...
April 6, 2017: Endocrine
https://www.readbyqxmd.com/read/28507607/gene-variants-in-the-fto-gene-are-associated-with-adiponectin-and-tnf-alpha-levels-in-gestational-diabetes-mellitus
#4
Renata Saucedo, Jorge Valencia, Claudia Gutierrez, Lourdes Basurto, Marcelino Hernandez, Edgardo Puello, Guadalupe Rico, Gloria Vega, Arturo Zarate
BACKGROUND: Obesity may have a role in the development of gestational diabetes mellitus (GDM). Single-nucleotide-polymorphisms (SNPs) of the FTO (fat mass and obesity associated) gene have been associated with obesity. The aim of this study was to investigate SNPs rs8050136, rs9939609, and rs1421085 of the FTO gene in women with GDM and their associations with maternal pre-pregnancy weight and body mass index, gestational weight gain and mediators of insulin resistance in GDM like leptin, adiponectin, ghrelin and tumor necrosis factor-alpha (TNF-alpha), compared with healthy pregnant controls...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28507343/non-alcoholic-fatty-liver-disease-vascular-inflammation-and-insulin-resistance-are-exacerbated-by-trail-deletion-in-mice
#5
Siân P Cartland, Hanis H Harith, Scott W Genner, Lei Dang, Victoria C Cogger, Melissa Vellozzi, Belinda A Di Bartolo, Shane R Thomas, Leon A Adams, Mary M Kavurma
Non-alcoholic fatty liver disease (NAFLD) incorporates steatosis, non-alcoholic steato-hepatitis (NASH) and liver cirrhosis, associating with diabetes and cardiovascular disease (CVD). TNF-related apoptosis-inducing ligand (TRAIL) is protective of CVD. We aimed to determine whether TRAIL protects against insulin resistance, NAFLD and vascular injury. Twelve-week high fat diet (HFD)-fed Trail (-/-) mice had increased plasma cholesterol, insulin and glucose compared to wildtype. Insulin tolerance was impaired with TRAIL-deletion, with reduced p-Akt, GLUT4 expression and glucose uptake in skeletal muscle...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28505082/supervised-clustering-of-adipokines-and-hormonal-receptors-predict-prognosis-in-a-population-of-obese-women-with-type-1-endometrial-cancer
#6
Jennifer Uzan, Enora Laas, Issam Abd Alsamad, Dounia Skalli, Dhouha Mansouri, Bassam Haddad, Cyril Touboul
Obesity is a major risk factor for endometrial cancer (EC). Yet, its impact on prognosis is controversial. Obesity is associated with metabolic and hormonal dysregulation as well as adipokines increase. The aim of this study was to characterize the expression of biological factors related to obesity within the tumor and evaluate their impact on prognosis. One hundred and thirty-six patients, including 55 obese patients, with endometrioid type I EC operated by total hysterectomy were included in this retrospective study conducted in a Tertiary teaching hospital between 2000 and 2013...
May 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28503098/absence-of-4-1bb-reduces-obesity-induced-atrophic-response-in-skeletal-muscle
#7
Ngoc Hoan Le, Chu-Sook Kim, Thai Hien Tu, Byung-Sam Kim, Taesun Park, Jung Han Yoon Park, Tsuyoshi Goto, Teruo Kawada, Tae Youl Ha, Rina Yu
Obesity-induced inflammation causes skeletal muscle atrophy accompanied by disruption of oxidative metabolism and is implicated in metabolic complications such as insulin resistance and type 2 diabetes. We previously reported that 4-1BB, a member of the tumor necrosis factor receptor superfamily, participated in obesity-induced skeletal muscle inflammation. Here, we show that the absence of 4-1BB in obese mice fed a high-fat diet led to a decrease in expression of atrophic factors (MuRF1 and Atrogin-1) with suppression of NF-κB activity, and that this was accompanied by increases in mitochondrial oxidative metabolic genes/proteins (e...
2017: Journal of Inflammation
https://www.readbyqxmd.com/read/28500724/grape-seed-proanthocyanidin-extract-ameliorates-inflammation-and-adiposity-by-modulating-gut-microbiota-in-high-fat-diet-mice
#8
Wen Liu, Shaoqian Zhao, Jiqiu Wang, Juan Shi, Yingkai Sun, Weiqing Wang, Guang Ning, Jie Hong, Ruixin Liu
SCOPE: Obesity and associated metabolic complications is a worldwide public health issue. Gut microbiota has been recently linked to obesity and its related inflammation. In this study, we have explored the anti-inflammatory effect of grape seed proanthocyanindin extract (GSPE) in the high-fat diet (HFD)-induced obesity and identified the contribution of the gut microbiota to GSPE effects on metabolism. METHODS AND RESULTS: Mice were fed a normal diet and a high-fat diet with or without GSPE (300mg/kg body weight/day) by oral gavage for 7 weeks...
May 12, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28497325/the-effect-of-pressure-controlled-inverse-ratio-ventilation-on-lung-protection-in-obese-patients-undergoing-gynecological-laparoscopic-surgery
#9
Lili Xu, Jianjun Shen, Min Yan
SPECIFIC AIM: To examine the effects of pressure-controlled inverse ratio ventilation (PCIRV) and volume-control ventilation (VCV) on arterial oxygenation, pulmonary function, hemodynamics, levels of surfactant protein A (SP-A), and tumor necrosis factor-α (TNF-α) in obese patients undergoing gynecological laparoscopic surgery. METHODS: Sixty patients, body mass index (BMI) ≥30 kg/m(2), scheduled for elective gynecological laparoscopic surgery were enrolled in the study...
May 11, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28489922/contribution-of-thrombin-reactive-brain-pericytes-to-blood-brain-barrier-dysfunction-in-an-in-vivo-mouse-model-of-obesity-associated-diabetes-and-an-in-vitro-rat-model
#10
Takashi Machida, Fuyuko Takata, Junichi Matsumoto, Tomoyuki Miyamura, Ryosuke Hirata, Ikuya Kimura, Yasufumi Kataoka, Shinya Dohgu, Atsushi Yamauchi
Diabetic complications are characterized by the dysfunction of pericytes located around microvascular endothelial cells. The blood-brain barrier (BBB) exhibits hyperpermeability with progression of diabetes. Therefore, brain pericytes at the BBB may be involved in diabetic complications of the central nervous system (CNS). We hypothesized that brain pericytes respond to increased brain thrombin levels in diabetes, leading to BBB dysfunction and diabetic CNS complications. Mice were fed a high-fat diet (HFD) for 2 or 8 weeks to induce obesity...
2017: PloS One
https://www.readbyqxmd.com/read/28489469/significant-se-selectin-levels-reduction-after-6-months-of-anti-tnf-%C3%AE-therapy-in-non-diabetic-patients-with-moderate-to-severe-psoriasis
#11
Fernanda Genre, Susana Armesto, Alfonso Corrales, Raquel López-Mejías, Sara Remuzgo-Martínez, Trinitario Pina, Begoña Ubilla, Verónica Mijares, José Luis Martín-Varillas, Javier Rueda-Gotor, Virginia Portilla, Trinidad Dierssen-Sotos, Marcos Antonio González-López, María Del Carmen González-Vela, Ricardo Blanco, Javier Llorca, José Luis Hernández, Miguel Ángel González-Gay
PURPOSE: Psoriasis patients have high risk of atherosclerosis, characterized by endothelial dysfunction. We aimed to study the association of the endothelial activation biomarkers monocyte chemoattractant protein 1 (MCP-1), soluble (s) E-selectin and P-selectin with disease activity and severity in psoriasis patients treated with anti-TNF-α therapy. Also, to evaluate the relationship of metabolic syndrome features with these biomarkers and the effect of anti-TNF-α therapy on these molecules...
May 10, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28487013/placental-pim-1-expression-is-increased-in-obesity-and-regulates-cytokine-and-toll-like-receptor-mediated-inflammation
#12
Stella Liong, Gillian Barker, Martha Lappas
INTRODUCTION: Obesity is a growing epidemic, and as a consequence the number of obese pregnancies has also increased. Pregnancy is characterised by maternal and placental inflammation which is intensified with maternal obesity. The proviral integration site for Moloney murine leukemic virus (Pim)-1 protein is a serine/threonine kinase involved in a wide range of inflammatory diseases. In relation to obesity, however, its role has not been elucidated in human placenta. The aims were to determine the placental expression of Pim-1 with pre-existing maternal obesity and its role in regulating placental inflammation associated with obesity...
May 2017: Placenta
https://www.readbyqxmd.com/read/28484748/tangeretin-improves-glucose-uptake-in-a-coculture-of-hypertrophic-adipocytes-and-macrophages-by-attenuating-inflammatory-changes
#13
Hye-Sun Shin, Seong-Il Kang, Hee-Chul Ko, Deok-Bae Park, Se-Jae Kim
Obesity is characterized by a state of chronic low-grade inflammation and insulin resistance, which are aggravated by the interaction between hypertrophic adipocytes and macrophages. In this study, we investigated the effects of tangeretin on inflammatory changes and glucose uptake in a coculture of hypertrophic adipocytes and macrophages. Tangeretin decreased nitric oxide production and the expression of interleukin (IL)-6, IL-1β, tumor necrosis factor-α, inducible nitric oxide synthase, and cyclooxygenase-2 in a coculture of 3T3-L1 adipocytes and RAW 264...
March 2017: Balsaeng'gwa Saengsig
https://www.readbyqxmd.com/read/28480767/evaluation-of-tumor-necrosis-factor-alpha-serum-level-in-obese-and-lean-women-with-clomiphene-citrate-resistant-polycystic-ovary-disease
#14
Emaduldin Seyam, Momen Hasan, Eissa M Khalifa, Ahmad Ramadan, Enas Hefzy
OBJECTIVE: The aim of this work was to investigate the level of the serum level of tumor necrosis factor alpha (TNF-α) as an inflammatory biomarker in lean and obese women with polycystic ovary disease (PCOD), who are resistant to clomiphene citrate (CCR-PCOD). PATIENTS AND DESIGN: It is a case-controlled study, where 150 (n = 150) PCOD women (study group), who are resistant to clomiphene citrate (CCR-PCOD) had been recruited, in addition to 100 (n = 100) women with PCOD, who are not resistant to clomiphene citrate (NCCR-PCOD) as the first control group, and another 100 women (n = 100) fertile women with normal reproductive health, as the second control group...
May 8, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28480505/cardamom-supplementation-improves-inflammatory-and-oxidative-stress-biomarkers-in-hyperlipidemic-overweight-and-obese-pre-diabetic-women-a-randomized-double-blind-clinical-trial
#15
Shiva Kazemi, Fatemeh Yaghooblou, Fereydoun Siassi, Abbas Rahimi, Mahsa Ghavipour, Fariba Koohdani, Gity Sotoudeh
BACKGROUND: Several preclinical studies have shown that spices may decrease the risk of chronic diseases. However, it has been suggested that more clinical trials be carried out to strengthen this preclinical evidence. The purpose of the present study was to evaluate the effects of cardamom (Elettaria Cardamomum) supplementation on inflammation and oxidative stress in hyperlipidemic, overweight, and obese pre-diabetic women. METHODS: This randomized, placebo-controlled, double-blind clinical trial was conducted on 80 pre-diabetic subjects...
May 8, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28479226/bifidobacterium-adolescentis-im38-ameliorates-high-fat-diet-induced-colitis-in-mice-by-inhibiting-nf-%C3%AE%C2%BAb-activation-and-lipopolysaccharide-production-by-gut-microbiota
#16
Su-Min Lim, Dong-Hyun Kim
Gut microbiota play essential roles in the regulation of human metabolism via symbiotic interactions with the host. Prolonged consumption of high-fat diet (HFD) elevates the Firmicutes to Bacteroidetes ratio and lipopolysaccharide (LPS) production by gut microbiota, thereby increasing the probability of developing metabolic and immune disorders such as obesity and colitis. The use of probiotics with anti-inflammatory properties has been suggested to counteract this effect. Here, we tested whether Bifidobacterium adolescentis IM38, which inhibited nuclear factor-kappa B (NF-κB) activation in Caco-2 cells and peritoneal macrophages and inhibited Escherichia coli LPS production, exerted an anticolitic effect in mice with HFD-induced obesity...
April 19, 2017: Nutrition Research
https://www.readbyqxmd.com/read/28475745/impact-of-visceral-obesity-and-metabolic-syndrome-on-the-postoperative-immune-inflammatory-and-endocrine-response-following-surgery-for-esophageal-adenocarcinoma
#17
S L Doyle, A M Mongan, C L Donohoe, G P Pidgeon, M Sherlock, J V Reynolds, J Lysaght
Visceral obesity and metabolic syndrome (MetSyn) represent a constellation of inflammation, insulin resistance, and hyperglycemia and are established risk factors for gastrointestinal cancer. However, their impact on the immune and inflammatory response after major upper gastrointestinal oncologic surgery is unknown. In 125 consecutive patients who underwent esophagectomy, C-reactive protein (CRP) and CRP:albumin levels were recorded preoperatively and on days 1, 3, 7, and 14 postoperatively. In a subset of 30 patients, circulating levels of IL-6, IL-8, IL-10, IL-12p70, IFN-γ, TNF-α, TGF-β, and cortisol were measured...
June 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28473444/role-of-adipose-tissue-endothelial-adam17-in-age-related-coronary-microvascular-dysfunction
#18
Huijuan Dou, Attila Feher, Alec C Davila, Maritza J Romero, Vijay S Patel, Vinayak M Kamath, Monika Beck Gooz, R Daniel Rudic, Rudolf Lucas, David J Fulton, Neal L Weintraub, Zsolt Bagi
OBJECTIVE: A disintegrin and metalloproteinase ADAM17 (tumor necrosis factor-α [TNF]-converting enzyme) regulates soluble TNF levels. We tested the hypothesis that aging-induced activation in adipose tissue (AT)-expressed ADAM17 contributes to the development of remote coronary microvascular dysfunction in obesity. APPROACH AND RESULTS: Coronary arterioles (CAs, ≈90 µm) from right atrial appendages and mediastinal AT were examined in patients (aged: 69±11 years, BMI: 30...
May 4, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28471828/nonalcoholic-fatty-liver-disease-can-be-predicted-by-retinal-vascular-changes-in-patients-with-obesity-without-hypertension-or-diabetes
#19
Maria E Romero-Ibarguengoitia, Arturo Herrera-Rosas, Alfredo A Domínguez-Mota, Jinny T Camas-Benitez, María F Serratos-Canales, Mireya León-Hernández, Antonio González-Chávez, Eduardo López-Ortiz, Srinivas Mummidi, Ranvidranth Duggirala, Juan C López-Alvarenga
OBJECTIVE: To evaluate the utility of predicting nonalcoholic fatty liver disease (NAFLD) and obesity by retinal vascular changes (RVC) found in fundoscopy and to determine whether this is related to a low-grade inflammatory process. METHODS: We carried out a cross-sectional analysis that included 152 (ages 18-45 years) patients divided into four groups: NAFLD and BMI less than 25, absence of NAFLD and BMI less than 25, NAFLD and BMI more than 30, and absence of NAFLD and BMI more than 30...
May 3, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28459555/ameliorative-effect-of-ecklonia-cava-polyphenol-extract-on-renal-inflammation-associated-with-aberrant-energy-metabolism-and-oxidative-stress-in-high-fat-diet-induced-obese-mice
#20
Hyeyoon Eo, Ji Eun Park, You-Jin Jeon, Yunsook Lim
Immoderate fat accumulation causes both oxidative stress and inflammation, which can induce kidney damage in obesity. Previously, Ecklonia cava has shown anti-inflammatory and antioxidative effects. Our group aimed to investigate whether E. cava polyphenol extract (ECPE) improves renal damage in high fat diet (HFD)-induced obese mice through regulation of not only energy metabolism but also oxidative stress and inflammation. After obesity induction by HFD, the mice were treated with different dosages of ECPE (100 or 500 mg/kg/day) by gavage for 12 weeks...
May 5, 2017: Journal of Agricultural and Food Chemistry
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