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https://www.readbyqxmd.com/read/29775627/acquisition-of-tumorigenic-potential-and-therapeutic-resistance-in-cd133-subpopulation-of-prostate-cancer-cells-exhibiting-stem-cell-like-characteristics
#1
Rajnee Kanwal, Sanjeev Shukla, Ethan Walker, Sanjay Gupta
The role of CD133 (Prominin-1) as a cancer stem cell marker may be useful for therapeutic approaches and prognostication in prostate cancer patients. We investigated the stem-cell-related function and biological features of a subpopulation of CD133+ cells isolated from established primary human prostate cancer cell lines. The CD133+ cells sorted from human prostate cancer 22Rv1 exhibited high clonogenic and tumorigenic capabilities, sphere forming capacity and serially reinitiated transplantable tumors in NOD-SCID mice...
May 15, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29771846/educational-exposure-to-transgender-patient-care-in-otolaryngology-training
#2
Benjamin B Massenburg, Shane D Morrison, Vania Rashidi, Craig Miller, David W Grant, Christopher S Crowe, Nathalia Velasquez, Justin R Shinn, Jacob E Kuperstock, Deepa J Galaiya, Scott R Chaiet, Amit D Bhrany
OBJECTIVE: Gender dysphoria is estimated to occur in over 1 million people in the United States. With decreasing stigma regarding the transgender population, it is likely more patients will seek medical and surgical gender transition as parts of their treatment. However, otolaryngologists may lack training in gender-confirming surgery. This study aims to determine the current state of transgender-related education in the United States otolaryngology training programs and to evaluate trainee perceptions regarding the importance of such training...
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29766598/dying-at-home-in-rural-residential-aged-care-a-mixed-methods-study-in-the-snowy-monaro-region-australia
#3
Suzanne Rainsford, Christine B Phillips, Nicholas J Glasgow, Roderick D MacLeod, Robert B Wiles
Residential aged care (RAC) is a significant provider of end-of-life care for people aged 65 years and older. Rural residents perceive themselves as different to their urban counterparts. Most studies describing place of death (PoD) in RAC are quantitative and reflect an urban voice. Using a mixed-methods design, this paper examines the PoD of 80 RAC residents (15 short-stay residents who died in RAC during respite or during an attempted step-down transition from hospital to home, and 65 permanent residents), within the rural Snowy Monaro region, Australia, who died between 1 February 2015 and 31 May 2016...
May 16, 2018: Health & Social Care in the Community
https://www.readbyqxmd.com/read/29764635/ten-year-experience-with-student-pharmacist-research-within-a-health-system-and-education-center
#4
Elizabeth Landrum Michalets, Charlene Williams, Irene Park
INTRODUCTION: Skills gained from research experience allow student pharmacists to evolve as practitioners, innovators and perpetual learners in an increasingly complex healthcare environment. Data published regarding pharmacy resident research are focused on external dissemination rates and research programs. Little is published regarding student research. METHODS: This descriptive study was a five-year before and after comparison between the existing co-curricular model and a new longitudinal, 12-month research advanced pharmacy practice experience (L-APPE) model for student pharmacist research...
March 2018: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29762799/integrated-behavioral-health-care-in-family-medicine-residencies-a-cera-survey
#5
Christine Jacobs, Jay A Brieler, Joanne Salas, Renée M Betancourt, Peter F Cronholm
BACKGROUND AND OBJECTIVES: Behavioral health integration (BHI) in primary care settings is critical to mental health care in the United States. Family medicine resident experience in BHI in family medicine residency (FMR) continuity clinics is essential preparation for practice. We surveyed FMR program directors to characterize the status of BHI in FMR training. METHODS: Using the Council of Academic Family Medicine Educational Research Alliance (CERA) 2017 survey, FMR program directors (n=478, 261 respondents, 54...
May 2018: Family Medicine
https://www.readbyqxmd.com/read/29762655/longitudinal-physical-activity-patterns-among-older-adults-a-latent-transition-analysis
#6
Stephen J Mooney, Spruha Joshi, Magdalena Cerdá, Gary J Kennedy, John R Beard, Andrew G Rundle
Most epidemiologic studies of physical activity measure either total energy expenditure or engagement in a single activity type, such as walking. These approaches may gloss over important nuances in activity patterns. We performed a latent transition analysis to identify patterns of activity types as well as neighborhood and individual determinants of changes in those activity patterns over two years in a cohort of 2,023 older adult residents of New York City, NY, surveyed between 2011 and 2013. We identified seven latent classes: 1) Mostly Inactive, 2) Walking, 3) Exercise, 4) Household Activities and Walking, 5) Household Activities and Exercise, 6) Gardening and Household Activities, and 7) Gardening, Household Activities, and Exercise...
May 14, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29758627/time-fractional-characterization-of-brine-reaction-and-precipitation-in-porous-media
#7
Jianping Xu, Guancheng Jiang
Brine reaction and precipitation in porous media sometimes occur in the presence of a strong fluid flowing field, which induces the mobilization of the precipitated salts and distorts their spatial distribution. It is interesting to investigate how the distribution responds to such mobilization. We view these precipitates as random walkers in the complex inner space of the porous media, where they make stochastic jumps among locations and possibly wait between successive transitions. In consideration of related experimental results, the waiting time of the precipitates at a particular position is allowed to range widely from short sojourn to permanent residence...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29756328/serum-derived-carcinoembryonic-antigen-cea-activates-fibroblasts-to-induce-a-local-re-modeling-of-the-extracellular-matrix-that-favors-the-engraftment-of-cea-expressing-tumor-cells
#8
Aws Abdul-Wahid, Marzena Cydzik, Nicholas W Fischer, Aaron Prodeus, John E Shively, Anne Martel, Samira Alminawi, Zeina Ghorab, Neil L Berinstein, Jean Gariépy
Elevated levels of the carcinoembryonic antigen (CEA; CEACAM5) in the serum of colorectal cancer (CRC) patients represent a clinical biomarker that correlates with disease recurrence. However, a mechanistic role for soluble CEA (sCEA) in tumor progression and metastasis remains to be established. In this study, we report that sCEA acts as a paracrine factor, activating human fibroblasts by signalling through both the STAT3 and AKT1-mTORC1 pathways, promoting their transition to a cancer-associated fibroblast (CaF) phenotype...
May 14, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29756061/anaesthesiology-trainees-and-their-needs-a-romanian-perspective-results-from-a-european-survey
#9
Liana Valeanu, Mihai Stefan, Diogo Sobreira Fernandes, Michela Rauseo, Bernardo Matias, Cornelia Predoi, Serban Bubenek, Daniela Filipescu
Anaesthesiology training is going through continuous transformations worldwide. Recent data from a European Survey on anaesthesiology postgraduate trainees and their concerns have been published for the first time, following an initiative by the European Society of Anaesthesiology. Among the responders of this survey, 10.8% were represented by Romanian trainees. The main needs of the Romanian anaesthesiology trainees who completed the questionnaire were, in descending order educational contents/EDAIC, technical skills, exchange programmes, residency workload, residency costs and autonomy transition...
April 2018: Romanian Journal of Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/29747875/young-adults-opioid-use-trajectories-from-nonmedical-prescription-opioid-use-to-heroin-drug-injection-drug-treatment-and-overdose
#10
Honoria Guarino, Pedro Mateu-Gelabert, Jennifer Teubl, Elizabeth Goodbody
INTRODUCTION: Recent research has begun to explore the transition from nonmedical use of prescription opioids (POs) to heroin and injection drug use, adding to earlier literature identifying factors that influence the transition from intranasal to injection use of heroin. However, little research has explored how these transitions are embedded within young people's broader opioid use trajectories - individual pathways that may also include experiences of nonfatal overdose and drug treatment...
May 1, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29743615/human-intestinal-pro-inflammatory-cd11c-high-ccr2-cx3cr1-macrophages-but-not-their-tolerogenic-cd11c-ccr2-cx3cr1-counterparts-are-expanded-in-inflammatory-bowel-disease
#11
D Bernardo, A C Marin, S Fernández-Tomé, A Montalban-Arques, A Carrasco, E Tristán, L Ortega-Moreno, I Mora-Gutiérrez, A Díaz-Guerra, R Caminero-Fernández, P Miranda, F Casals, M Caldas, M Jiménez, S Casabona, F De la Morena, M Esteve, C Santander, M Chaparro, J P Gisbert
Although macrophages (Mϕ) maintain intestinal immune homoeostasis, there is not much available information about their subset composition, phenotype and function in the human setting. Human intestinal Mϕ (CD45+ HLA-DR+ CD14+ CD64+ ) can be divided into subsets based on the expression of CD11c, CCR2 and CX3CR1. Monocyte-like cells can be identified as CD11chigh CCR2+ CX3CR1+ cells, a phenotype also shared by circulating CD14+ monocytes. On the contrary, their Mϕ-like tissue-resident counterparts display a CD11c- CCR2- CX3CR1- phenotype...
May 9, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29737995/imaging-the-ordering-of-a-weakly-adsorbed-two-dimensional-condensate-ambient-pressure-microscopy-and-spectroscopy-of-co-2-molecules-on-rutile-tio-2-110
#12
Rebecca C E Hamlyn, Mausumi Mahapatra, David C Grinter, Fang Xu, Si Luo, Robert M Palomino, Shyam Kattel, Iradwikanari Waluyo, Ping Liu, Dario J Stacchiola, Sanjaya D Senanayake, José A Rodriguez
Disorder-Order transitions in a weakly adsorbed two-dimensional film have been identified for the first time using ambient-pressure scanning tunneling microscopy (AP-STM) and X-ray photoelectron spectroscopy (AP-XPS). As of late, great effort has been devoted to the capture, activation and conversion of carbon dioxide (CO2), a ubiquitous greenhouse gas and by-product of many chemical processes. The high stability and non-polar nature of CO2 leads to weak bonding with well-defined surfaces of metals and oxides...
May 8, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29734721/commuting-mode-choice-in-a-high-density-city-do-land-use-density-and-diversity-matter-in-hong-kong
#13
Yi Lu, Guibo Sun, Chinmoy Sarkar, Zhonghua Gou, Yang Xiao
Hong Kong is a densely populated and transit-oriented Chinese city, which provides an ideal urban environment with which to study the various successful facets of land use policy as a model for potential replication to curb increasing car use in other Chinese cities. We examine the commuting mode choice of 203,900 households living in 4768 street blocks in Hong Kong from 2011 census. A street block is the smallest planning unit, made up of one or more housing estates with a homogenous built environment and socioeconomic status...
May 4, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29734002/the-plastid-envelope-chloroplast-manganese-transporter1-is-essential-for-manganese-homeostasis-in-arabidopsis
#14
Marion Eisenhuta, Natalie Hoecker, Sidsel Birkelund Schmidt, Rubek Merina Basgaran, Samantha Flachbart, Peter Jahns, Tabea Eser, Stefan Geimer, Søren Husted, Andreas P M Weber, Dario Leister, Anja Schneider
The transition metal manganese (Mn) is indispensable for photoautotrophic growth, since photosystem II (PSII) employs an inorganic Mn4 CaO5 cluster for water splitting. Here, we show that the Arabidopsis membrane protein CHLOROPLAST MANGANESE TRANSPORTER 1 (CMT1) is involved in chloroplast Mn homeostasis. CMT1 is the closest homolog of -the previously characterized thylakoid Mn transporter- PHOTOSYNTHESIS AFFECTED MUTANT71 (PAM71). In contrast to PAM71, CMT1 resides at the chloroplast envelope and is ubiquitously expressed...
May 4, 2018: Molecular Plant
https://www.readbyqxmd.com/read/29733062/actitud-del-personal-m%C3%A3-dico-de-un-servicio-de-pediatr%C3%A3-a-ante-la-muerte-de-los-pacientes
#15
Luz María Sánchez-Sánchez, Edreí Daniel López-Córdova, Pedro Siller-Gómez
Introducción: Los médicos de hospitales de tercer nivel requie-ren alta competencia emocional, ya que enfrentan las de-mandas de enfermos terminales y sus fami-liares. Objetivo: Evaluar la actitud de médicos de un servicio de pediatría ante la muerte de los pacientes. Método: Médicos adscritos y residentes de pediatría contestaron anónimamente el Cuestionario de Actitudes ante la Muerte (CAM). Se utilizaron frecuencias absolutas, porcentajes, medias, desviaciones estándar, t de Student y chi cuadrado...
2018: Gaceta Médica de México
https://www.readbyqxmd.com/read/29725587/do-programs-for-runaway-and-homeless-youth-work-a-qualitative-exploration-from-the-perspectives-of-youth-clients-in-diverse-settings
#16
Marya Gwadz, Robert M Freeman, Alexandra H Kutnick, Elizabeth Silverman, Amanda S Ritchie, Charles M Cleland, Noelle R Leonard, Aradhana Srinagesh, Jamie Powlovich, James Bolas
Runaway and homeless youth (RHY) comprise a large population of young people who reside outside the control and protection of parents and guardians and who experience numerous traumas and risk factors, but few buffering resources. Specialized settings have developed to serve RHY, but little is known about their effects. The present cross-sectional qualitative descriptive study, grounded in the positive youth development approach and the Youth Program Quality Assessment model, addressed this gap in the literature...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29723424/core-entrustable-professional-activities-in-clinical-pharmacology-for-entering-residency-value-of-interprofessional-health-care-teams-in-medication-prescribing-and-medication-error-prevention
#17
Lawrence J Cohen, Vera S Donnenberg, Peter H Wiernik, William C Newman, Nduka Amankulor
In recent years, health care has been increasingly delivered by interprofessional teams in the inpatient, outpatient, and transition-of-care arenas. For many reasons, effective communication between patient-centered care teams and patients is critically important in order to optimize care, ensure patient safety, and prevent medical and medication misadventures. In rapid-paced, high-stress medical environments, it is especially important to carefully evaluate the causes of all misadventures in a manner that avoids assigning blame and identifies the root causes and, through team activity, leads to development of remedies that reduce the likelihood of future misadventures...
May 3, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29720659/chromatin-analysis-in-human-early-development-reveals-epigenetic-transition-during-zga
#18
Jingyi Wu, Jiawei Xu, Bofeng Liu, Guidong Yao, Peizhe Wang, Zili Lin, Bo Huang, Xuepeng Wang, Tong Li, Senlin Shi, Nan Zhang, Fuyu Duan, Jia Ming, Xiangyang Zhang, Wenbin Niu, Wenyan Song, Haixia Jin, Yihong Guo, Shanjun Dai, Linli Hu, Lanlan Fang, Qiujun Wang, Yuanyuan Li, Wei Li, Jie Na, Wei Xie, Yingpu Sun
Upon fertilization, drastic chromatin reorganization occurs during preimplantation development 1 . However, the global chromatin landscape and its molecular dynamics in this period remain largely unexplored in humans. Here we investigate chromatin states in human preimplantation development using an improved assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) 2 . We find widespread accessible chromatin regions in early human embryos that overlap extensively with putative cis-regulatory sequences and transposable elements...
May 2, 2018: Nature
https://www.readbyqxmd.com/read/29717401/modelling-mortality-and-discharge-of-hospitalized-stroke-patients-using-a-phase-type-recovery-model
#19
Bruce Jones, Sally McClean, David Stanford
We model the length of in-patient hospital stays due to stroke and the mode of discharge using a phase-type stroke recovery model. The model allows for three different types of stroke: haemorrhagic (the most severe, caused by ruptured blood vessels that cause brain bleeding), cerebral infarction (less severe, caused by blood clots) and transient ischemic attack or TIA (the least severe, a mini-stroke caused by a temporary blood clot). A four-phase recovery process is used, where the initial phase depends on the type of stroke, and transition from one phase to the next depends on the age of the patient...
May 1, 2018: Health Care Management Science
https://www.readbyqxmd.com/read/29717381/parental-support-and-youth-occupational-attainment-help-or-hindrance
#20
Anna Manzoni
Although several concerns surround the transition to adulthood and youth increasingly rely on parental support, our knowledge about the implications of parental support for youth development and transition to adulthood is limited. This study fills this gap by conceptualizing development within a life course perspective that links social inequality and early life course transitions. It draws on a subsample of youth observed between age 18 and 28 from the Transition to Adulthood supplement of the Panel Study of Income Dynamics 2005-2015 (N = 7,542; 53% female, 51...
May 2, 2018: Journal of Youth and Adolescence
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