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https://www.readbyqxmd.com/read/28929716/-developing-an-algorithm-based-on-health-and-social-sources-to-stratify-general-population-in-different-levels-of-health-socio-sanitary-frailty-and-disability
#1
Laura Andreoni, Antonio Giampiero Russo
OBJECTIVES: to describe an innovative algorithm to classify the general population, in homogeneous groups of severity and complexity of disease and real needs, by using three dimensions: health, frailty, and disability. DESIGN: retrospective cohort study. SETTING AND PARTICIPANTS: the study includes the population covered by the Agency for health protection of Metropolitan Area of Milan (3,4 million of habitants). We identified two cohorts of residents: the first at 01...
May 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28927380/financial-burden-of-survivors-of-medically-managed-myocardial-infarction-and-its-association-with-selected-social-determinants-and-quality-of-life-in-a-lower-middle-income-country
#2
P K B Mahesh, M W Gunathunga, S Jayasinghe, S M Arnold, D S V Mallawarachchi, S K Perera, U A D Wijesinghe
BACKGROUND: Burden from ischemic heart disease is rising in Sri Lanka due to the demographic and epidemiological transitions. Documented literature is scarce on quality of life, financial burden and its determinants in relation to myocardial infarction (MI). This study was done to describe the financial burden among the survivors of MI managed only with drugs (i.e. those who did not undergo Percutaneous Coronary Intervention or Coronary Artery Bypass Graft) and its association with selected social determinants (SDHs) and quality of life (QOL)...
September 19, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28924488/trion-valley-coherence-in-monolayer-semiconductors
#3
Kai Hao, Lixiang Xu, Fengcheng Wu, Philipp Nagler, Kha Tran, Xin Ma, Christian Schüller, Tobias Korn, Allan H MacDonald, Galan Moody, Xiaoqin Li
The emerging field of valleytronics aims to exploit the valley pseudospin of electrons residing near Bloch band extrema as an information carrier. Recent experiments demonstrating optical generation and manipulation of exciton valley coherence (the superposition of electron-hole pairs at opposite valleys) in monolayer transition metal dichalcogenides (TMDs) provide a critical step towards control of this quantum degree of freedom. The charged exciton (trion) in TMDs is an intriguing alternative to the neutral exciton for control of valley pseudospin because of its long spontaneous recombination lifetime, its robust valley polarization, and its coupling to residual electronic spin...
June 2017: 2d Materials
https://www.readbyqxmd.com/read/28922608/j-si-h-coupling-constants-of-activated-si-h-bonds
#4
Petra Meixner, Kilian Batke, Andreas Fischer, Dominik Schmitz, Georg Eickerling, Marcel Kalter, Klaus Ruhland, Klaus Eichele, José E Barquera-Lozada, Nicola P M Casati, Fabio Montisci, Piero Macchi, Wolfgang Scherer
We outline in this combined experimental and theoretical NMR study that sign and magnitude of J(Si,H) coupling constants provide reliable indicators to evaluate the extent of the oxidative addition of Si-H bonds in hydrosilane complexes. In combination with experimental electron density studies and MO analyses a simple structure-property relationship emerges: positive J(Si,H) coupling constants are observed in cases where M → L π-back-donation (M = transition metal; L = hydrosilane ligand) dominates. The corresponding complexes are located close to the terminus of the respective oxidative addition trajectory...
September 18, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28912950/quality-improvement-regarding-handoff
#5
Scott Studeny, Lauren Burley, Kelsey Cowen, Melanie Akers, Kelly O'Neill, Susan L Flesher
BACKGROUND AND OBJECTIVES: Previous studies have emphasized the importance of effectual communication during patient handoffs. The objectives of this study were to (1) implement a resident-driven quality improvement project to improve handoffs by including key elements that are necessary for a safe and effective handoff. We chose to use the IPASS (illness severity, patient summary, action items, situation awareness and contingency planning, synthesis by receiver) mnemonic as our standardized handoff model; (2) Consider balancing measures in an effort to be aware of any negative effects of our interventions on resident satisfaction with the system...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28911627/assessment-of-the-pharmacokinetics-removal-rate-of-hemodialysis-and-safety-of-lactulose-in-hemodialysis-patients
#6
Cheng-Jui Lin, Chi-Feng Pan, Sy-Yeuan Ju, Hsuan-Kai Tzeng, Shen-Wei Chen, Jhu-Ting Syu, Chih-Jen Wu
Lactulose is often used to treat hepatic encephalopathy or constipation, and also exhibits benefits to chronic renal insufficiency due to reduce nitrogen-related products in serum. The present study investigated the pharmacokinetics of lactulose, its removal rate through dialysis, and safety by administering lactulose 6.5 g (Lagnos Jelly Divided Pack 16.05 g) orally to six hemodialysis patients who resided in Taiwan. As a result, the means of maximum plasma concentrations (Cmax) and Time to reach Cmax (Tmax) were 3090 ± 970 ng/mL and 6...
October 2016: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28904399/semaphorin-3%C3%A2-c-drives-epithelial-to-mesenchymal-transition-invasiveness-and-stem-like-characteristics-in-prostate-cells
#7
Kevin J Tam, Daniel H F Hui, Wilson W Lee, Mingshu Dong, Tabitha Tombe, Ivy Z F Jiao, Shahram Khosravi, Ario Takeuchi, James W Peacock, Larissa Ivanova, Igor Moskalev, Martin E Gleave, Ralph Buttyan, Michael E Cox, Christopher J Ong
Prostate cancer (PCa) is among the most commonly-occurring cancers worldwide and a leader in cancer-related deaths. Local non-invasive PCa is highly treatable but limited treatment options exist for those with locally-advanced and metastatic forms of the disease underscoring the need to identify mechanisms mediating PCa progression. The semaphorins are a large grouping of membrane-associated or secreted signalling proteins whose normal roles reside in embryogenesis and neuronal development. In this context, semaphorins help establish chemotactic gradients and direct cell movement...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28903578/mental-health-services-use-trends-in-canadian-veterans-a-population-based-retrospective-cohort-study-in-ontario
#8
Alyson L Mahar, Alice B Aiken, Heidi Cramm, Marlo Whitehead, Patti Groome, Paul Kurdyak
OBJECTIVE: A substantial evidence base in the peer-reviewed literature exists investigating mental illness in the military, but relatively less is documented about mental illness in veterans. This study uses provincial, administrative data to study the use of mental health services by Canadian veterans in Ontario. METHOD: This was a retrospective cohort study of Canadian Armed Forces and Royal Canadian Mounted Police veterans who were released between 1990 and 2013 and resided in Ontario...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28901665/kansas-nurse-leader-residency-programme-advancing-leader-knowledge-and-skills
#9
Qiuhua Shen, Jill Peltzer, Cynthia Teel, Janet Pierce
AIMS: To evaluate the effectiveness of the Kansas Nurse Leader Residency (KNLR) programme in improving nurses' leadership knowledge and skills and its acceptability, feasibility and fidelity. BACKGROUND: The Future of Nursing Report (Institute of Medicine, 2011) calls for nurses to lead change and advance health. The 6-month KNLR programme was developed by the Kansas Action Coalition to support nurses' leadership development. METHODS: Nurses (n = 36) from four nursing specialties (acute care, long-term care, public health and school health) participated in the programme...
September 12, 2017: Journal of Nursing Management
https://www.readbyqxmd.com/read/28900753/fertility-treatment-for-the-transgender-community-a-public-opinion-study
#10
Randi H Goldman, Daniel J Kaser, Stacey A Missmer, Leslie V Farland, Scout, Rachel K Ashby, Elizabeth S Ginsburg
PURPOSE: The purposes of this study were to evaluate public opinion regarding fertility treatment and gamete cryopreservation for transgender individuals and identify how support varies by demographic characteristics. METHODS: This is a cross-sectional web-based survey study completed by a representative sample of 1111 US residents aged 18-75 years. Logistic regression was used to calculate odd ratios (ORs) and 95% confidence intervals (CIs) of support for/opposition to fertility treatments for transgender people by demographic characteristics, adjusting a priori for age, gender, race, and having a biological child...
September 12, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28898986/building-a-new-transfusion-service
#11
John R Hess, Brenda K Hayden, Virginia G Cruz-Cody, Max J Louzon, Erin E Tuott, Nina E Sen, Roxann Gary, Patrick J Ramos, Jennifer A Daniel-Johnson, Ryan A Metcalf, Monica B Pagano
Objectives: For over 60 years, Harborview Medical Center (HMC) in Seattle has received its blood components and pretransfusion testing from a centralized transfusion service operated by the regional blood supplier. In 2011, a hospital-based transfusion service (HBTS) was activated. Methods: After 5 years of operation, we evaluated the effects of the HBTS by reviewing records of hospital blood use, quality system events, blood product delivery times, and costs. Furthermore, the effects of in-house expertise on laboratory medicine resident and medical laboratory scientist student training, as well as regulatory and accrediting agency concerns, were reviewed...
August 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28894084/tbx3-dependent-amplifying-stem-cell-progeny-drives-interfollicular-epidermal-expansion-during-pregnancy-and-regeneration
#12
Ryo Ichijo, Hiroki Kobayashi, Saori Yoneda, Yui Iizuka, Hirokazu Kubo, Shigeru Matsumura, Satsuki Kitano, Hitoshi Miyachi, Tetsuya Honda, Fumiko Toyoshima
The skin surface area varies flexibly in response to body shape changes. Skin homeostasis is maintained by stem cells residing in the basal layer of the interfollicular epidermis. However, how the interfollicular epidermal stem cells response to physiological body shape changes remains elusive. Here, we identify a highly proliferative interfollicular epidermal basal cell population in the rapidly expanding abdominal skin of pregnant mice. These cells express Tbx3 that is necessary for their propagation to drive skin expansion...
September 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28891876/impact-of-a-nurse-residency-program-on-transition-to-specialty-practice
#13
Susan A Boyer, Krystal K Valdez-Delgado, Jody L Huss, Amber J Barker, Elizabeth A Mann-Salinas
A nurse residency program can support transition for new-to-specialty nurses but requires commitment of time and resources. This implementation project used a specialty residency program shown to be effective in a Burn Center, and translated it into the Emergency Department and Maternal Child Health area located within the same medical treatment facility. Preceptor survey responses and leadership assessment of program suitability provided data related to intervention impact. The evidence pertaining to developing specialty knowledge, skills, competency, and clinical reasoning validated program efficacy...
September 2017: Journal for Nurses in Professional Development
https://www.readbyqxmd.com/read/28890948/green-environment-and-incident-depression-in-south-africa-a-geospatial-analysis-and-mental-health-implications-in-a-resource-limited-setting
#14
Andrew Tomita, Alain M Vandormael, Diego Cuadros, Enrico Di Minin, Vuokko Heikinheimo, Frank Tanser, Rob Slotow, Jonathan K Burns
BACKGROUND: Unprecedented levels of habitat transformation and rapid urbanisation are changing the way individuals interrelate with the natural environment in developing countries with high economic disparities. Although the potential benefit of green environments for mental health has been recognised, population-level evidence to this effect is scarce. We investigated the effect of green living environment in potentially countering incident depression in a nationally representative survey in South Africa...
July 2017: The Lancet. Planetary health
https://www.readbyqxmd.com/read/28888975/solvent-responsive-floating-liquid-crystalline-molecularly-imprinted-polymers-for-gastroretentive-controlled-drug-release-system
#15
Li-Ping Zhang, Xiao-Lin Wang, Qian-Qian Pang, Yan-Ping Huang, Lei Tang, Meng Chen, Zhao-Sheng Liu
Liquid crystalline-molecularly imprinted polymer (LC-MIP) particles were first found to possess the floating behavior on the aqueous medium. Combined with molecular recognition, the LC-MIP was fabricated as a novel class of the controlled-release gastric retentive DDS. The LC-MIP was made using co-polymerization of methacrylic acid, 4-methyl phenyl dicyclohexyl ethylene (LC monomer with vinyl group), and ethylene glycol dimethacrylate with S-amlodipine (S-AML) as model template drug. The optimum condition of the preparation of LC-MIP has been obtained relying on release behaviors of S-AML from the LC-MIP...
September 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28888420/transition-to-residency-the-successful-development-and-implementation-of-a-nonclinical-elective-in-perioperative-management
#16
Heather McDonald, Nada Gawad, Isabelle Raîche, Fraser D Rubens
OBJECTIVE: Few medical school programs in Canada address challenges related to the significant increase in responsibility for patient care between medical school and residency. This is particularly important in surgery and anesthesia due to the high-acuity care required during the perioperative period. The purpose of this study was to develop and assess a program that would help students transition to surgical and anesthesia residencies, in terms of knowledge acquisition, clinical decision-making skills, and subjective preparedness...
September 6, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28888403/transitioning-from-a-level-ii-to-level-i-trauma-center-increases-resident-patient-exposure
#17
Brian Carpenter, Lena Levine, Tim Niacaris, Sumihiro Suzuki
Increased patient exposure has been shown to improve residency training as determined by better patient outcomes. The transition of John Peter Smith Hospital from a level II to a level I trauma center in 2009 provided a unique opportunity to investigate the direct effects of increased patient exposure on residency training in a relatively controlled setting. We evaluated the effect of the transition to a level I trauma center on residency training. In 2014, we examined the annual facility reports and separated the data into 2 groups: level II (2001 to 2008) and level I (2010 to 2013)...
September 6, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28887842/seasonally-induced-alterations-of-some-facial-signs-in-caucasian-women-impact-of-a-daily-application-of-a-photo-protective-product
#18
Frederic Flament, Brigitte Gautier, Amelie-Marie Benize, Aude Charbonneau, Matthieu Cassier
OBJECTIVES: These were two-fold: i) to record through standardized pictures, the possible changes in 14 facial signs induced, in a 6-month period, by the periodical shift from winter to summer in a group of 42 Caucasian women residing in Paris and ii) to appraise the preventive effects of a strong photo-protective product, daily applied to their face by an additional group (N=40) of women of same age-range and presenting same severities of facial signs in winter. METHODS: Facial signs (structural and pigmentation-related) were graded in blind by a panel of 12 experts from photographs taken under standard conditions...
September 8, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28882683/structured-operative-autonomy-an-institutional-approach-to-enhancing-surgical-resident-education-without-impacting-patient-outcomes
#19
Brandon M Wojcik, Zhi Ven Fong, Madhukar S Patel, David C Chang, Dustin R Long, Haytham Ma Kaafarani, Emil Petrusa, John T Mullen, Keith D Lillemoe, Roy Phitayakorn
BACKGROUND: Though barriers to granting surgical residents autonomy in the operating room are well described, few have proposed practical strategies to overcome them. Our department adopted a multidisciplinary approach to develop a rotation that aimed to grant chief residents structured operative autonomy. In this study, we assess the feasibility of implementation, impact on patient safety and educational benefit to residents following the program's pilot year. STUDY DESIGN: During a one-month rotation, chief residents began cases alone using their own operative block time...
September 4, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28877372/desquamation-takes-center-stage-at-the-origin-of-proliferative-inflammatory-atrophy-epithelial-mesenchymal-transition-and-stromal-growth-in-benign-prostate-hyperplasia
#20
Danilo Ferrucci, Manoel F Biancardi, Umar Nishan, Rafaela Rosa-Ribeiro, Hernandes F Carvalho
In this commentary we propose a relationship between desquamation, initially described as the collective detachment and deletion of epithelial cell in the prostate gland after castration, and proliferative inflammatory atrophy (PIA) and stromal growth in benign prostate hyperplasia (BPH). First, in response to diverse stimuli, including inflammatory mediators, epithelial cells desquamate and leave a large surface of the luminal side of the basement membrane (BM) exposed. Basal cells are activated into intermediate-type cells, which change morphology to cover and remodel the exposed BM (simple atrophy) to a new physiological demand (such as in the hypoandrogen environment, simulated by surgical and/or chemical castration) and/or to support re-epithelialization (under normal androgen levels)...
September 6, 2017: Cell Biology International
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