keyword
MENU ▼
Read by QxMD icon Read
search

Hair cycle

keyword
https://www.readbyqxmd.com/read/28711498/promotion-of-hair-growth-by-newly-synthesized-ceramide-mimetic-compound
#1
Bu-Mahn Park, Soon-Sun Bak, Kyung-Oh Shin, Minhee Kim, Daehwan Kim, Sang-Hun Jung, Sekyoo Jeong, Young Kwan Sung, Hyunjong Kim
Based on the crucial roles of ceramides in skin barrier function, use of ceramides or their structural mimetic compounds, pseudoceramides, as cosmetic ingredients are getting more popular. While currently used pseudoceramides are intended to substitute the structural roles of ceramides in stratum corneum, development of bioactive pseudoceramides has been repeatedly reported. In this study, based on the potential involvement of sphingolipids in hair cycle regulation, we investigated the effects of newly synthesized pseudoceramide, bis-oleamido isopropyl alcohol (BOI), on hair growth using cultured human hair follicles and animal models...
July 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28709434/integrating-multi-omics-analyses-of-nonomuraea-dietziae-to-reveal-the-role-of-soybean-oil-in-4-oh-meleu-4-csa-overproduction
#2
Huanhuan Liu, Di Huang, Lina Jin, Cheng Wang, Shaoxiong Liang, Jianping Wen
BACKGROUND: Nonomuraea dietziae is a promising microorganism to mediate the region-specific monooxygenation reaction of cyclosporine A (CsA). The main product [(4'-OH)MeLeu](4)-CsA possesses high anti-HIV/HCV and hair growth-stimulating activities while avoiding the immunosuppressive effect of CsA. However, the low conversion efficiency restricts the clinical application. In this study, the production of [(4'-OH)MeLeu](4)-CsA was greatly improved by 55.6% from 182.8 to 284.4 mg/L when supplementing soybean oil into the production medium, which represented the highest production of [(4'-OH)MeLeu](4)-CsA so far...
July 14, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28700789/hair-repigmentation-during-immunotherapy-treatment-with-an-anti-programmed-cell-death-1-and-anti-programmed-cell-death-ligand-1-agent-for-lung-cancer
#3
Noelia Rivera, Aram Boada, M Isabel Bielsa, M Teresa Fernández-Figueras, Enric Carcereny, M Teresa Moran, Carlos Ferrándiz
Importance: New targeted therapies for cancer have been released in recent years, opening new horizons in the treatment of patients with cancer. However, their related adverse events (AE) are not fully characterized. Hair repigmentation (HR) is a nondescribed effect secondary to anti-programmed cell death 1 (anti-PD-1) and anti-programmed cell death ligand 1 (anti-PD-L1 ) therapy for treatment of lung cancer (LC), in opposition to the vitiligo reactions that develop during melanoma treatment...
July 12, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28695824/a-multi-scale-model-for-hair-follicles-reveals-heterogeneous-domains-driving-rapid-spatiotemporal-hair-growth-patterning
#4
Qixuan Wang, Ji Won Oh, Hye-Lim Lee, Anukriti Dhar, Tao Peng, Raul Ramos, Christian Fernando Guerrero-Juarez, Xiaojie Wang, Ran Zhao, Xiaoling Cao, Jonathan Le, Melisa A Fuentes, Shelby C Jocoy, Antoni R Rossi, Brian Vu, Kim Pham, Xiaoyang Wang, Nanda Maya Mali, Jung Min Park, June-Hyug Choi, Hyunsu Lee, Julien Legrand, Eve Kandyba, Jung Chul Kim, Moonkyu Kim, John Foley, Zhengquan Yu, Krzysztof Kobielak, Bogi Andersen, Kiarash Khosrotehrani, Qing Nie, Maksim V Plikus
The control principles behind robust cyclic regeneration of hair follicles (HFs) remain unclear. Using multi-scale modeling we show that coupling inhibitors and activators with physical growth of HFs is sufficient to drive periodicity and excitability of hair regeneration. Model simulations and experimental data reveal that mouse skin behaves as a heterogeneous regenerative field, composed of anatomical domains where HFs have distinct cycling dynamics. Interactions between fast-cycling chin and ventral HFs and slow-cycling dorsal HFs produce bilaterally symmetric patterns...
July 11, 2017: ELife
https://www.readbyqxmd.com/read/28695384/carbonic-anhydrase-inhibitors-induce-developmental-toxicity-during-zebrafish-embryogenesis-especially-in-the-inner-ear
#5
Hiroko Matsumoto, Shoko Fujiwara, Hisako Miyagi, Nobuhiro Nakamura, Yasuhiro Shiga, Toshihiro Ohta, Mikio Tsuzuki
In vertebrates, carbonic anhydrases (CAs) play important roles in ion transport and pH regulation in many organs, including the eyes, kidneys, central nervous system, and inner ear. In aquatic organisms, the enzyme is inhibited by various chemicals present in the environment, such as heavy metals, pesticides, and pharmaceuticals. In this study, the effects of CA inhibitors, i.e., sulfonamides [ethoxyzolamide (EZA), acetazolamide (AZA), and dorzolamide (DZA)], on zebrafish embryogenesis were investigated. In embryos treated with the sulfonamides, abnormal development, such as smaller otoliths, an enlarged heart, an irregular pectoral fin, and aberrant swimming behavior, was observed...
July 10, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/28670518/hair-follicle-generation-by-injections-of-adult-human-follicular-epithelial-and-dermal-papilla-cells-into-nude-mice
#6
Mohammadali Nilforoushzadeh, Elham Rahimi Jameh, Fariba Jaffary, Ehsan Abolhasani, Gelavizh Keshtmand, Hajar Zarkob, Parvaneh Mohammadi, Nasser Aghdami
OBJECTIVE: Dermal papilla and hair epithelial stem cells regulate hair formation and the growth cycle. Damage to or loss of these cells can cause hair loss. Although several studies claim to reconstitute hairs using rodent cells in an animal model, additional research is needed to develop a stable human hair follicle reconstitution protocol. In this study, we have evaluated hair induction by injecting adult cultured human dermal papilla cells and a mixture of hair epithelial and dermal papilla cells in a mouse model...
July 2017: Cell Journal
https://www.readbyqxmd.com/read/28668474/dermal-blimp1-acts-downstream-of-epidermal-tgf%C3%AE-and-wnt-%C3%AE-catenin-to-regulate-hair-follicle-formation-and-growth
#7
Stephanie B Telerman, Emanuel Rognoni, Inês Sequeira, Angela Oliveira Pisco, Beate M Lichtenberger, Oliver Culley, Priyalakshmi Viswanathan, Ryan R Driskell, Fiona M Watt
Blimp1 is a transcriptional repressor that regulates cell growth and differentiation in multiple tissues, including skin. While in the epidermis Blimp1 is important for keratinocyte and sebocyte differentiation, its role in dermal fibroblast is unclear. Here we show that Blimp1 is dynamically regulated in dermal papilla (DP) cells during hair follicle (HF) morphogenesis and the postnatal hair cycle, preceding dermal Wnt/β-catenin activation. Blimp1 ablation in E12.5 mouse dermal fibroblasts delayed HF morphogenesis and growth and prevented new HF formation following wounding...
June 28, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28652426/transcriptome-analysis-of-skin-from-smp30-gnl-knockout-mice-reveals-the-effect-of-ascorbic-acid-deficiency-on-skin-and-hair
#8
Koji Wakame, Ken-Ichi Komatsu, Akifumi Nakata, Keisuke Sato, Akira Takaguri, Hirofumi Masutomi, Takayuki Nagashima, Hironobu Uchiyama
BACKGROUND/AIM: Senescence marker protein-30/gluconolactonase knockout mice (SMP-30/GNL-KO) are a very useful model for clarifying the involvement of vitamin C (VC) in aging-related diseases. In this study, the effects of VC deficiency on skin and hair growth were investigated using SMP-30/GNL-KO mice by RNA sequencing. MATERIALS AND METHODS: SMP-30/GNL-KO mice were given water containing 1.5 g/l VC until up to 8 weeks after birth to maintain a VC concentration in their organs and plasma equivalent to that in wild-type mice...
July 2017: In Vivo
https://www.readbyqxmd.com/read/28650975/defective-glucocorticoid-receptor-signaling-and-keratinocyte-autonomous-defects-contribute-to-skin-phenotype-of-mouse-embryos-lacking-the-hsp90-co-chaperone-p23
#9
Marta Madon-Simon, Iwona Grad, Pilar Bayo, Paloma Pérez, Didier Picard
p23 is a small acidic protein with intrinsic molecular chaperone activity. It is best known as a co-chaperone of the major cytosolic molecular chaperone Hsp90. p23 binds the N-terminus of Hsp90 and stabilizes the ATP-bound and N-terminally closed Hsp90 dimer. It is in this configuration that many Hsp90 clients are most stably bound. Considering the important role of p23 in the Hsp90 cycle, it came as a surprise that it is not absolutely essential for viability in the budding yeast or for mouse development. Mice without p23 develop quite normally until birth and then all die perinatally because of immature lungs...
2017: PloS One
https://www.readbyqxmd.com/read/28634657/longitudinal-perceptions-of-the-side-effects-of-chemotherapy-in-patients-with-gynecological-cancer
#10
Hui-Chun Hsu, Su-Yu Tsai, Shang-Liang Wu, Shiow-Roug Jeang, Mei-Yao Ho, Wen-Shiung Liou, An-Jen Chiang, Tsung-Hsien Chang
PURPOSE: This study aimed to assess the incidence and difference of side effects among six courses of chemotherapy (C/T) in gynecological cancer patients. METHODS: The study period was from Sep. 2010 to Dec. 2011 at the Kaohsiung Veterans General Hospital in Taiwan. The treating protocols, courses, and drugs of C/T in patient were considered according to the different malignant cancers and clinical conditions. The patient data of age, marriage status, education, religion, and experiences of C/T were collected...
June 21, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28630424/characterization-of-slow-cycling-corneal-limbal-epithelial-cells-identifies-putative-stem-cell-markers
#11
R Sartaj, C Zhang, P Wan, Z Pasha, V Guaiquil, A Liu, J Liu, Y Luo, E Fuchs, M I Rosenblatt
In order to identify reliable markers of corneal epithelial stem cells, we employed an inducible transgenic "pulse-chase" murine model (K5Tta × TRE-H2BGFP) to localize, purify, and characterize slow cycling cells in the cornea. The retention of GFP labeling in slowly dividing cells allowed for localization of these cells to the corneal limbus and their subsequent purification by FACS. Transcriptome analysis from slow cycling cells identified differentially expressed genes when comparing to GFP(-) faster-dividing cells...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28627318/effects-of-gamma-rays-on-the-regeneration-of-murine-hair-follicles-in-the-natural-hair-cycle
#12
Kimihiko Sugaya
PURPOSE: This review evaluates the effects of γ-rays on the regeneration of murine hair follicles in the natural hair cycle. A series of studies were performed to investigate this issue, in which the whole bodies of C57BL/10JHir mice in the 1st telogen phase of the hair cycle were irradiated with γ-rays. RESULTS: The dermis of the irradiated skin showed a decrease in hair follicle density and induction of curved hair follicles along with the presence of white hairs and hypopigmented hair bulbs in the 2nd and 3rd anagen phases...
July 7, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28626889/from-basal-cell-morphogenesis-to-the-alopecia-induced-by-hedgehog-inhibitors-connecting-the-dots
#13
REVIEW
C Dessinioti, C Antoniou, A J Stratigos
The deciphering of the hedgehog (Hh) signaling pathway implicated in the tumorigenesis of basal cell carcinoma (BCC), led to the development of targeted drug therapies, e.g. the hedgehog pathway inhibitors (HPI), vismodegib and sonidegib. In the skin, physiologic Hh signaling is activated in growing hair follicles, where it is required for proliferation of the epithelium of hair follicles during morphogenesis and for their postnatal growth. The effects of HPI treatment leading to the regression of BCC and the development of alopecia, underpin the central role of the Hh pathway in BCC formation as well as hair cycling...
June 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28624120/histologic-features-of-chronic-cutaneous-lupus-erythematosus-of-the-scalp-using-horizontal-sectioning-emphasis-on-follicular-findings
#14
Hye Jin Chung, Lynne J Goldberg
BACKGROUND: Chronic cutaneous lupus erythematosus (CCLE) often affects the scalp resulting in scarring alopecia. While histopathologic findings of CCLE have been well described, there is little written on the morphologic changes to the hair follicles in this condition. OBJECTIVE: We aim to determine the histopathologic findings of hair follicles in CCLE of the scalp. METHODS: We conducted a retrospective study of 33 transversely sectioned skin biopsy specimens of CCLE of the scalp at the Skin Pathology Laboratory at Boston University between April 2005 and March 2015...
August 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28607955/wound-healing-protects-against-chemotherapy-induced-alopecia-in-young-rats-via-up-regulating-interleukin-1%C3%AE-mediated-signaling
#15
Olivera Stojadinovic, Tongyu C Wikramanayake, Alexandra C Villasante Fricke, Natalie C Yin, Liang Liang, Eleanor Hinde, Julia Escandon, Marjana Tomic-Canic, David M Ansell, Ralf Paus, Joaquin J Jimenez
Wound healing is a complex process regulated by various cell types and a plethora of mediators. While interactions between wounded skin and the hair follicles (HFs) could induce HF neogenesis or promote wound healing, it remains unknown whether the wound healing-associated signaling milieu can be manipulated to protect against alopecia, such as chemotherapy-induced alopecia (CIA). Utilizing a well-established neonatal rat model of CIA, we show here that skin wounding protects from alopecia caused by several clinically relevant chemotherapeutic regimens, and that protection is dependent on the time of wounding and hair cycle stage...
May 2017: Heliyon
https://www.readbyqxmd.com/read/28602615/pten-mediates-activation-of-core-clock-protein-bmal1-and-accumulation-of-epidermal-stem-cells
#16
Chiara Zagni, Luciana O Almeida, Tarek Balan, Marco T Martins, Luciana K Rosselli-Murai, Petros Papagerakis, Rogerio M Castilho, Cristiane H Squarize
Tissue integrity requires constant maintenance of a quiescent, yet responsive, population of stem cells. In the skin, hair follicle stem cells (HFSCs) that reside within the bulge maintain tissue homeostasis in response to activating cues that occur with each new hair cycle or upon injury. We found that PTEN, a major regulator of the PI3K-AKT pathway, controlled HFSC number and size in the bulge and maintained genomically stable pluripotent cells. This regulatory function is central for HFSC quiescence, where PTEN-deficiency phenotype is in part regulated by BMAL1...
July 11, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28599846/planar-cell-polarity-dependent-and-independent-functions-in-the-emergence-of-tissue-scale-hair-follicle-patterns
#17
Maureen Cetera, Liliya Leybova, Frank W Woo, Michael Deans, Danelle Devenport
Hair follicles of the mammalian epidermis display local order and global alignment, a complex pattern instructed by the core planar cell polarity (PCP) pathway. Here we address the contributions of core PCP genes, Van Gogh-like and Frizzled, to the establishment, local refinement, and global order of embryonic and postnatal hair follicles. We find that, similar to Fz6 mutants, the disordered hair patterns of Vangl2 mutants are refined over time and eventually corrected. In both mutants, we find that tissue-level reorientation occurs through locally coordinated follicle rotation at stereotyped locations...
August 1, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28594472/gel-network-shampoo-formulation-and-hair-health-benefits
#18
Jennifer M Marsh, Mark Brown, Tim Felts, Howard Hutton, Mike Vatter, Shane Whitaker, Fred Wireko, Peter Styczynski, Chuiying Li, Ian Henry
OBJECTIVE: The objective of this work was to create a shampoo formula that contains a stable ordered gel network structure that delivers fatty alcohols inside hair. METHODS: X-ray diffraction (SAXS and WAXS), SEM and DSC have been used to confirm formation of the ordered Lβ gel network with fatty alcohol (cetyl and stearyl alcohol) and an anionic surfactant (SLE1S). Micro autoradiography and extraction methods using GC-MS were used to confirm penetration of fatty alcohols into hair and cyclic fatigue testing was used to measure hair strength...
June 8, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28584752/body-to-scalp-evolving-trends-in-body-hair-transplantation
#19
REVIEW
Kuldeep Saxena, Sandeep S Savant
Follicular unit extraction (FUE) is becoming an increasingly popular method for hair restoration. As FUE leaves behind no linear scars, it is more suitable to harvest from various body areas including beard, chest, and extremities in hirsute individuals. Body hair characteristics such as thickness, length, and hair cycle may not completely match to that of the scalp hair. The techniques of harvesting body hairs are more time consuming, requiring higher degree of skill than regular scalp FUE. Body hair transplantation can be successfully used either alone or in combination with scalp hair in advanced grades of baldness, for improving the cosmetic appearance of hairlines and in scarring alopecia when there is paucity of donor scalp hair...
May 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28580147/the-quantification-of-reproductive-hormones-in-the-hair-of-captive-adult-brown-bears-and-their-application-as-indicators-of-sex-and-reproductive-state
#20
Marc Cattet, Gordon B Stenhouse, David M Janz, Luciene Kapronczai, Joy Anne Erlenbach, Heiko T Jansen, O Lynne Nelson, Charles T Robbins, John Boulanger
Recognizing the potential value of steroid hormone measurements to augment non-invasive genetic sampling, we developed procedures based on enzyme-linked immunoassays to quantify reproductive steroid hormone concentrations in brown bear (Ursus arctos) hair. Then, using 94 hair samples collected from eight captive adult bears over a 2-year period, we evaluated (i) associations between hair concentrations of testosterone, progesterone, estradiol and cortisol; (ii) the effect of collecting by shaving vs. plucking; and (iii) the utility of reproductive hormone profiles to differentiate sex and reproductive state...
2017: Conservation Physiology
keyword
keyword
110667
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"