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https://www.readbyqxmd.com/read/28526588/adam10-and-%C3%AE-secretase-regulate-sensory-regeneration-in-the-avian-vestibular-organs
#1
Mark E Warchol, Jennifer Stone, Matthew Barton, Jeffrey Ku, Rose Veile, Nicolas Daudet, Michael Lovett
The loss of sensory hair cells from the inner ear is a leading cause of hearing and balance disorders. The mammalian ear has a very limited ability to replace lost hair cells, but the inner ears of non-mammalian vertebrates can spontaneously regenerate hair cells after injury. Prior studies have shown that replacement hair cells are derived from epithelial supporting cells and that the differentiation of new hair cells is regulated by the Notch signaling pathway. The present study examined molecular influences on regeneration in the avian utricle, which has a particularly robust regenerative ability...
May 16, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28510329/isolation-of-stem-cells-and-progenitors-from-mouse-epidermis
#2
Lana Kostic, Egor Sedov, Despina Soteriou, Yahav Yosefzon, Yaron Fuchs
The epidermis consists of several distinct compartments including the interfollicular epidermis (IFE), sweat glands, sebaceous glands (SGs), and the hair follicle (HF). While the IFE and SGs are in a constant state of self-renewal, the HF cycles between phases of growth, destruction, and rest. The hair follicle stem cells (HFSCs) that fuel this perpetual cycle have been well described and are located in a niche termed the bulge. These bulge SCs express markers such as CD34 and Keratin 15 (K15), enabling the isolation of these cells...
May 16, 2017: Current Protocols in Stem Cell Biology
https://www.readbyqxmd.com/read/28500774/the-transcriptional-landscape-of-seasonal-coat-colour-moult-in-the-snowshoe-hare
#3
Mafalda S Ferreira, Paulo C Alves, Colin M Callahan, João P Marques, L Scott Mills, Jeffrey M Good, José Melo-Ferreira
Seasonal coat colour change is an important adaptation to seasonally changing environments but the evolution of this and other circannual traits remains poorly understood. In this study we use gene expression to understand seasonal coat colour moulting in wild snowshoe hares (Lepus americanus). We used hair colour to follow the progression of the moult, simultaneously sampling skin from three moulting stages in hares collected during the peak of the spring moult from white winter to brown summer pelage. Using RNA-sequencing, we tested if patterns of expression were consistent with predictions based on the established phases of the hair growth cycle...
May 13, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28491023/characterization-of-the-transcriptomes-of-lgr5-hair-cell-progenitors-and-lgr5-supporting-cells-in-the-mouse-cochlea
#4
Cheng Cheng, Luo Guo, Ling Lu, Xiaochen Xu, ShaSha Zhang, Junyan Gao, Muhammad Waqas, Chengwen Zhu, Yan Chen, Xiaoli Zhang, Chuanying Xuan, Xia Gao, Mingliang Tang, Fangyi Chen, Haibo Shi, Huawei Li, Renjie Chai
Cochlear supporting cells (SCs) have been shown to be a promising resource for hair cell (HC) regeneration in the neonatal mouse cochlea. Previous studies have reported that Lgr5+ SCs can regenerate HCs both in vitro and in vivo and thus are considered to be inner ear progenitor cells. Lgr5+ progenitors are able to regenerate more HCs than Lgr5- SCs, and it is important to understand the mechanism behind the proliferation and HC regeneration of these progenitors. Here, we isolated Lgr5+ progenitors and Lgr5- SCs from Lgr5-EGFP-CreERT2/Sox2-CreERT2/Rosa26-tdTomato mice via flow cytometry...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28475144/undariopsis-peterseniana-promotes-hair-growth-by-the-activation-of-wnt-%C3%AE-catenin-and-erk-pathways
#5
Jung-Il Kang, Min-Kyoung Kim, Ji-Hyeok Lee, You-Jin Jeon, Eun-Kyoung Hwang, Young-Sang Koh, Jin-Won Hyun, Soon-Young Kwon, Eun-Sook Yoo, Hee-Kyoung Kang
In this study, we investigated the effect and mechanism of Undariopsis peterseniana, an edible brown alga, on hair growth. The treatment of vibrissa follicles with U. peterseniana extract ex vivo for 21 days significantly increased the hair-fiber lengths. The U. peterseniana extract also significantly accelerated anagen initiation in vivo. Moreover, we found that U. peterseniana extract was able to open the KATP channel, which may contribute to increased hair growth. The U. peterseniana extract decreased 5α-reductase activity and markedly increased the proliferation of dermal papilla cells, a central regulator of the hair cycle...
May 5, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28464095/breeding-and-genetics-symposium-resilience-and-lessons-from-studies-in-genetics-of-heat-stress
#6
I Misztal
Production environments are expected to change, mostly to a hotter climate but also possibly more extreme and drier. Can the current generation of farm animals cope with the changes or should it be specifically selected for changing conditions? In general, genetic selection produces animals with a smaller environmental footprint but also with smaller environmental flexibility. Some answers are coming from heat-stress research across species, with heat tolerance partly understood as a greater environmental flexibility...
April 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28463974/the-histological-characteristics-age-related-thickness-change-of-skin-and-expression-of-the-hsps-in-the-skin-during-hair-cycle-in-yak-bos-grunniens
#7
Xue Yang, Yan Cui, Jing Yue, Honghong He, Chuan Yu, Penggang Liu, Jun Liu, Xiandong Ren, Yun Meng
OBJECTIVE: This experiment was conducted to study the histological characteristics, age-related thickness changes, and expression of HSPs in the skin of yak. METHODS: A total of 20 yaks (10 males and 10 females) were used. Different regions of the normal skin of three different ages (newborn, half-year-old and adult) of yaks were harvested for histological study and thickness measurement. Biopsy samples were taken from the scapula regions of the skin from the same five approximately 1-year-old yaks during the hair cycle (telogen, anagen and catagen)...
2017: PloS One
https://www.readbyqxmd.com/read/28462983/alterations-in-metabolic-patterns-have-a-key-role-in-diagnosis-and-progression-of-primrose-syndrome
#8
Alberto Casertano, Paolo Fontana, Raoul C Hennekam, Marco Tartaglia, Rita Genesio, Tina Barbaro Dieber, Lucia Ortega, Lucio Nitsch, Daniela Melis
Primrose syndrome is characterized by unusual facial features, macrocephaly, intellectual disability, enlarged, and calcified external ears, sparse body hair, and distal muscle wasting. Nine patients have been described in the literature. The disorder is due to missense mutations in ZBTB20. Here we describe one newly diagnosed 18-month-old patient and provide 10 year follow-up of an earlier reported patient, highlighting the progression and complexity of the disorder. Metabolic studies showed reduced glucose tolerance with prevalence of amino acids and fatty acids catabolism, ketogenesis, and gluconeogenesis, resulting in a Krebs cycle reversion...
April 30, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28423056/hair-and-stress-a-pilot-study-of-hair-and-cytokine-balance-alteration-in-healthy-young-women-under-major-exam-stress
#9
Eva M J Peters, Yvonne Müller, Wenke Snaga, Herbert Fliege, Anett Reißhauer, Thomas Schmidt-Rose, Heiner Max, Dorothea Schweiger, Matthias Rose, Johannes Kruse
Mouse models show that experimental stress mimicking prolonged life-stress exposure enhances neurogenic inflammation, induces adaptive immunity cytokine-imbalance characterized by a shift to Type 1 T-helper cell cytokines and increases apoptosis of epithelial cells. This affects hair growth in otherwise healthy animals. In this study, we investigate whether a prolonged naturalistic life-stress exposure affects cytokine balance and hair parameters in healthy humans. 33 (18 exam, 15 comparison) female medical students with comparable sociobiological status were analyzed during a stressful final examination period, at three points in time (T) 12 weeks apart...
2017: PloS One
https://www.readbyqxmd.com/read/28413121/characterisation-of-cell-cycle-arrest-and-terminal-differentiation-in-a-maximally-proliferative-human-epithelial-tissue-lessons-from-the-human-hair-follicle-matrix
#10
Talveen S Purba, Lars Brunken, Michael Peake, Asim Shahmalak, Asuncion Chaves, Enrique Poblet, Ralf Paus
Human hair follicle (HF) growth and hair shaft formation require terminal differentiation-associated cell cycle arrest of highly proliferative matrix keratinocytes. However, the regulation of this complex event remains unknown. CIP/KIP family member proteins (p21(CIP1), p27(KIP1) and p57(KIP2)) regulate cell cycle progression/arrest, endoreplication, differentiation and apoptosis. Since they have not yet been adequately characterized in the human HF, we asked whether and where CIP/KIP proteins localise in the human hair matrix and pre-cortex in relation to cell cycle activity and HF-specific epithelial cell differentiation that is marked by keratin 85 (K85) protein expression...
April 2, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/28370423/chronological-changes-in-trichofolliculoma-folliculosebaceous-cystic-hamartoma-is-not-a-very-late-stage-trichofolliculoma
#11
Noriyuki Misago, Shin-Ichi Ansai, Takaya Fukumoto, Takashi Anan, Tetsunori Kimura, Tomokazu Nakao
Some authors have reported that the secondary hair follicles in trichofolliculomas (TF) undergo regressive changes and are subsequently replaced by the developed sebaceous elements, and that folliculosebaceous cystic hamartoma (FSCH) is a TF at a very late stage. In the present study, we revaluated the histopathological features of 40 TF lesions, focusing on their chronological changes. The results of the present study indicate that while the secondary follicles in the TF exhibited the hair cycle, the normal hair cycle was out of control, and tertiary hair follicles randomly developed from the involuting secondary follicles...
March 31, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28345588/macrophages-induce-akt-%C3%AE-catenin-dependent-lgr5-stem-cell-activation-and-hair-follicle-regeneration-through-tnf
#12
Xusheng Wang, Haiyan Chen, Ruiyun Tian, Yiling Zhang, Marina S Drutskaya, Chengmei Wang, Jianfeng Ge, Zhimeng Fan, Deqiang Kong, Xiaoxiao Wang, Ting Cai, Ying Zhou, Jingwen Wang, Jinmei Wang, Shan Wang, Zhihai Qin, Huanhuan Jia, Yue Wu, Jia Liu, Sergei A Nedospasov, Edward E Tredget, Mei Lin, Jianjun Liu, Yuyang Jiang, Yaojiong Wu
Skin stem cells can regenerate epidermal appendages; however, hair follicles (HF) lost as a result of injury are barely regenerated. Here we show that macrophages in wounds activate HF stem cells, leading to telogen-anagen transition (TAT) around the wound and de novo HF regeneration, mostly through TNF signalling. Both TNF knockout and overexpression attenuate HF neogenesis in wounds, suggesting dose-dependent induction of HF neogenesis by TNF, which is consistent with TNF-induced AKT signalling in epidermal stem cells in vitro...
March 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28340702/selective-solid-phase-extraction-of-jwh-synthetic-cannabinoids-by-using-computationally-designed-peptides
#13
Marcello Mascini, Camilla Montesano, German Perez, Joseph Wang, Dario Compagnone, Manuel Sergi
The objective of the present work is to demonstrate a rational way to prepare selective sorbents able to extract simultaneously several structural analogs. For this purpose the binding specificity of two hexapeptides computationally designed (VYWLVW and YYIGGF) versus four synthetic cannabinoids Naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH 018), naphthalen-1-yl-(1-butylindol-3-yl)methanone (JWH 073), (R)-(1-((1-methylpiperidin-2-yl)methyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone (AM 1220) and (R)-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-napthalenylmethanone (WIN 55) was computationally studied and then experimentally tested by solid-phase extraction (SPE) clean-up and ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) analysis...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28340685/research-techniques-made-simple-experimental-methodology-for-single-cell-mass-cytometry
#14
Tiago R Matos, Hongye Liu, Jerome Ritz
Growing recognition of the complexity of interactions within cellular systems has fueled the development of mass cytometry. The precision of time-of-flight mass spectrometry combined with the labeling of specific ligands with mass tags enables detection and quantification of more than 40 markers at a single-cell resolution. The 135 available detection channels allow simultaneous study of additional characteristics of complex biological systems across millions of cells. Cutting-edge mass cytometry by time-of-flight (CyTOF) can profoundly affect our knowledge of cell population heterogeneity and hierarchy, cellular state, multiplexed signaling pathways, proteolysis products, and mRNA transcripts...
April 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28335800/a-new-method-for-in-vitro-feeding-of-rhipicephalus-australis-formerly-rhipicephalus-microplus-larvae-a-valuable-tool-for-tick-vaccine-development
#15
Jos J A Trentelman, Jos A G M Kleuskens, Jos van de Crommert, Theo P M Schetters
BACKGROUND: Rhipicephalus microplus is a hard tick that has a major impact on cattle health in tropical and subtropical regions because it feeds on cattle and is implicated in the transmission of pathogens that cause diseases such as bovine anaplasmosis and babesiosis. Presently, acaricides are used to control tick infestation but this is becoming increasingly less effective due to the emergence of tick strains that are resistant to one or more classes of acaricides. Anti-tick vaccines are a promising alternative to control tick infestation in cattle...
March 23, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28329625/advanced-basal-cell-carcinomas-appear-preferentially-on-the-scalp-of-patients-with-basal-cell-carcinoma-nevus-syndrome
#16
Brittany Urso, Katelyn Updyke, James A Solomon
Basal Cell Carcinoma Nevus Syndrome is a rare condition in which patients need to meet certain major or minor diagnostic criteria or test positive for chromosome 9 or PTCH1 mutations to be diagnosed. The results of an internet based survey of self-identified adults with BCCNS which was launched through SurveyMonkey with access provided by the Basal Cell Carcinoma Nevus Syndrome Life Support Network (www.BCCNS.org). Of 45 respondents, 11 individuals reported having locally advanced BCCs and 6 individuals reported having both locally advanced and metastatic BCCs...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28324846/novel-alk5-inhibitor-tp0427736-reduces-tgf-%C3%AE-%C3%A3-induced-growth-inhibition-in-human-outer-root-sheath-cells-and-elongates-anagen-phase-in-mouse-hair-follicles
#17
Takumi Naruse, Mari Aoki, Natsuko Fujimoto, Seiji Arase, Hajimu Oura, Yasuji Ueda, Akiko Ikeda
BACKGROUND: Androgenic alopecia (AGA) occurs as a result of the contraction of the anagen phase because of the action of androgens on hair follicles. TGF-β production from dermal papillae is enhanced by androgens, and growth inhibition of hair-follicle cells is induced by TGF-β, and the hair cycle progresses from the anagen phase to the catagen phase. We investigated both the in vitro and in vivo potency of the newly identified ALK5 inhibitor TP0427736 {6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole}...
June 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28321536/effect-of-sinapic-acid-on-hair-growth-promoting-in-human-hair-follicle-dermal-papilla-cells-via-akt-activation
#18
Hyunju Woo, Seungjun Lee, Seungbeom Kim, Deokhoon Park, Eunsun Jung
Hair loss known as alopecia is caused by abnormal hair follicle cycling including shortening of the anagen (growth) phase and changing of hair follicle morphology with miniaturization. In accordance with the life extension, the quality of life is considered to be a most important thing. The yearning for healthy and beautiful hair and low self esteem due to hair loss had negative influence on the quality of life with psychosocial maladjustment. The objective of this research was to identify new compound that can be used as a drug to promote hair growth...
March 20, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28321398/unveiling-the-metabolic-changes-on-muscle-cell-metabolism-underlying-p-phenylenediamine-toxicity
#19
Igor Marín de Mas, Silvia Marín, Gisela Pachón, Juan C Rodríguez-Prados, Pedro Vizán, Josep J Centelles, Romà Tauler, Amaya Azqueta, Vitaly Selivanov, Adela López de Ceraín, Marta Cascante
Rhabdomyolysis is a disorder characterized by acute damage of the sarcolemma of the skeletal muscle leading to release of potentially toxic muscle cell components into the circulation, most notably creatine phosphokinase (CK) and myoglobulin, and is frequently accompanied by myoglobinuria. In the present work, we evaluated the toxicity of p-phenylenediamine (PPD), a main component of hair dyes which is reported to induce rhabdomyolysis. We studied the metabolic effect of this compound in vivo with Wistar rats and in vitro with C2C12 muscle cells...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/28317864/targeted-deletion-of-crif1-in-mouse-epidermis-impairs-skin-homeostasis-and-hair-morphogenesis
#20
Jung-Min Shin, Dae-Kyoung Choi, Kyung-Cheol Sohn, Ji-Young Kim, Myung Im, Young Lee, Young-Joon Seo, Minho Shong, Jeung-Hoon Lee, Chang Deok Kim
The epidermis, which consists mainly of keratinocytes, acts as a physical barrier to infections by regulating keratinocyte proliferation and differentiation. Hair follicles undergo continuous cycling to produce new one. Therefore, optimum supply of energy from the mitochondria is essential for maintaining skin homeostasis and hair growth. CRIF1 is a mitochondrial protein that regulates mitoribosome-mediated synthesis and insertion of mitochondrial oxidative phosphorylation polypeptides into the mitochondrial membrane in mammals...
March 20, 2017: Scientific Reports
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