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https://www.readbyqxmd.com/read/29923313/establishment-of-an-in-vitro-organoid-model-of-dermal-papilla-of-human-hair-follicle
#1
Abhishak C Gupta, Shikha Chawla, Ashok Hegde, Divya Singh, Balaji Bandyopadhyay, Chandrasekharan C Lakshmanan, Gurpreet Kalsi, Sourabh Ghosh
Human hair dermal papilla (DP) cells are specialized mesenchymal cells that play a pivotal role in hair regeneration and hair cycle activation. The current study aimed to first develop three-dimensional (3D) DP spheroids (DPS) with or without a silk-gelatin (SG) microenvironment, which showed enhanced DP-specific gene expression, resulting in enhanced extracellular matrix (ECM) production compared with a monolayer culture. We tested the feasibility of using this DPS model for drug screening by using minoxidil, which is a standard drug for androgenic alopecia...
June 19, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29922313/cellular-patterning-of-arabidopsis-roots-under-low-phosphate-conditions
#2
George Janes, Daniel von Wangenheim, Sophie Cowling, Ian Kerr, Leah Band, Andrew P French, Anthony Bishopp
Phosphorus is a crucial macronutrient for plants playing a critical role in many cellular signaling and energy cycling processes. In light of this, phosphorus acquisition efficiency is an important target trait for crop improvement, but it also provides an ecological adaptation for growth of plants in low nutrient environments. Increased root hair density has been shown to improve phosphorus uptake and plant health in a number of species. In several plant families, including Brassicaceae, root hair bearing cells are positioned on the epidermis according to their position in relation to cortex cells, with hair cells positioned in the cleft between two underlying cortex cells...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29915875/differential-expression-of-mir-let7a-in-hair-follicle-cycle-of-liaoning-cashmere-goats-and-identification-of-its-targets
#3
Tao Ma, Jianping Li, Qian Jiang, Sufang Wu, Huaizhi Jiang, Qiaoling Zhang
In order to improve the production and quality of Chinese cashmere, the research of hair follicle development has aroused more and more attention; the regulation mechanism of miRNA in hair follicle development has become a hot spot. A survey of transcriptome profiling screened 10 hair follicle-related miRNAs that were differentially expressed, including miR-let7a. In this study, the expression of miR-let7a was lower in anagen of hair follicle of cashmere goats than that in catagen of hair follicle of cashmere goats (p < 0...
June 18, 2018: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/29909529/expression-and-localization-of-vegfr-2-in-hair-follicles-during-induced-hair-growth-in-mice
#4
Xian-Jie Wu, Jing Jing, Zhong-Fa Lu, Min Zheng
Recently, VEGFR-2 has been detected not only in vascular and lymphatic endothelial cells but also in some non-vascular endothelial cells, particularly human hair follicles, sebaceous glands, and sweat glands. In addition, VEGFR-2 has been confirmed to play direct roles in hair follicle keratinocyte regulation beyond simply angiogenesis. To elucidate whether VEGFR-2 activation plays a role in hair follicle cycling regulation, immunofluorescence of VEGFR-2 expression was performed during hair cycling of the dorsum of the mouse induced by hair plucking...
June 16, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29890355/combined-laparoscopic-and-vaginal-cervicovaginal-reconstruction-using-acellular-porcine-small-intestinal-submucosa-sis-graft-in-a-patient-with-mayer-rokitansky-k%C3%A3-ster-hauser-syndrome-u5ac4v4
#5
Xuyin Zhang, Yan Ding, Keqin Hua, Songping Liu, Nan Jia
OBJECTIVE: To introduce a creation that combines laparoscopic and Wharton-Sheares-George cervicovaginal reconstruction using SIS graft in a patient with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome who had a rudimentary cavity (U5aC4V4). DESIGN: Video article introducing a new surgical technique. SETTING: University hospital. PATIENT(S): A 24-year-old patient had primary amenorrhea and irregular lower abdominal pain for 9 years...
June 8, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29870121/developing-product-environmental-footprint-category-rules-pefcr-for-shampoos-the-basis-for-comparable-life-cycle-assessments
#6
Laura Golsteijn, Lindsay Lessard, Jean-Florent Campion, Alexandre Capelli, Virginie D'Enfert, Henry King, Joachim Kremer, Michael Krugman, Hélène Orliac, Severine Roullet Furnemont, Werner Schuh, Mark Stalmans, Natasha Williams O'Hanlon, Manuela Coroama
In 2013, the European Commission launched the Environmental Footprint Rules pilot phase. This initiative aims at setting specific rules for life cycle assessment (LCA: raw material sourcing, production, logistics, use- and disposal phase) studies within one product category, so called product environmental footprint category rules (PEFCR), as well as for organisations, so called organisational environmental footprint sector rules (OEFSR). Such specific rules for measuring environmental performance throughout the life cycle should facilitate the comparability between LCA studies, and provide principles for communicating the environmental performance, such as transparency, reliability, completeness, and clarity...
June 5, 2018: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/29867341/characterization-of-lgr6-cells-as-an-enriched-population-of-hair-cell-progenitors-compared-to-lgr5-cells-for-hair-cell-generation-in-the-neonatal-mouse-cochlea
#7
Yanping Zhang, Luo Guo, Xiaoling Lu, Cheng Cheng, Shan Sun, Wen Li, Liping Zhao, Chuijin Lai, Shasha Zhang, Chenjie Yu, Mingliang Tang, Yan Chen, Renjie Chai, Huawei Li
Hair cell (HC) loss is irreversible because only very limited HC regeneration has been observed in the adult mammalian cochlea. Wnt/β-catenin signaling regulates prosensory cell proliferation and differentiation during cochlear development, and Wnt activation promotes the proliferation of Lgr5+ cochlear HC progenitors in newborn mice. Similar to Lgr5 , Lgr6 is also a Wnt downstream target gene. Lgr6 is reported to be present in adult stem cells in the skin, nail, tongue, lung, and mammary gland, and this protein is very important for adult stem cell maintenance in rapidly proliferating organs...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29864939/balance-between-fibroblast-growth-factor-10-and-secreted-frizzled-relate-protein-1-controls-the-development-of-hair-follicle-by-competitively-regulating-%C3%AE-catenin-signaling
#8
Haihua Zhang, Weixiao Nan, Shiyong Wang, Huazhe Si, Guangyu Li
Growth of hairs depends on the regular development of hair follicles which are hypothesized to be regulated by fibroblast growth factor 10 (FGF10) and secreted frizzled-relate protein-1 (sFRP1). In the current study, the effect of FGF10 or sFRP1 on hair follicle cells was assessed and the possible mechanism mediating the interaction between FGF10 and sFRP1 in hair follicle cells was explored. Out root sheath (ORS) and dermal papilla (DP) cells were isolated from mink skin tissues and subjected to administrations of FGF10 (50 ng/ml) or sFRP1 (10 ng/ml)...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29850524/mir-195-5p-regulates-hair-follicle-inductivity-of-dermal-papilla-cells-by-suppressing-wnt-%C3%AE-catenin-activation
#9
Ningxia Zhu, Keng Huang, Yang Liu, Huan Zhang, En Lin, Yang Zeng, Haihong Li, Yanming Xu, Bozhi Cai, Yanping Yuan, Yu Li, Changmin Lin
Dermal papilla (DP) cells play a vital role in hair follicle (HF) development and postnatal hair cycling. However, the abilities are lost on further culture. Recent studies have demonstrated significant influences of posttranscriptional regulation by microRNA (miRNA) on HF development. The current study aims to investigate how miRNAs regulate Wnt/ β -catenin to control HF inductivity of DP cells by performing microarray analysis in early- and late-passage DP cells and transfecting with miRNAs inhibitor or mimic...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29805107/mouse-intestinal-krt15-crypt-cells-are-radio-resistant-and-tumor-initiating
#10
Véronique Giroux, Julien Stephan, Priya Chatterji, Ben Rhoades, E Paul Wileyto, Andres J Klein-Szanto, Christopher J Lengner, Kathryn E Hamilton, Anil K Rustgi
Two principal stem cell pools orchestrate the rapid cell turnover in the intestinal epithelium. Rapidly cycling Lgr5+ stem cells are intercalated between the Paneth cells at the crypt base (CBCs) and injury-resistant reserve stem cells reside above the crypt base. The intermediate filament Keratin 15 (Krt15) marks either stem cells or long-lived progenitor cells that contribute to tissue repair in the hair follicle or the esophageal epithelium. Herein, we demonstrate that Krt15 labels long-lived and multipotent cells in the small intestinal crypt by lineage tracing...
June 5, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29801644/thermal-equilibrium-of-nellore-cattle-in-tropical-conditions-an-investigation-of-circadian-pattern
#11
Cíntia Carol de Melo Costa, Alex Sandro Campos Maia, Tami M Brown-Brandl, Marcos Chiquitelli Neto, Vinicius de França Carvalho Fonsêca
The aim of this work was to evaluate the diurnal patterns of physiological responses and the thermal regulation of adult Nellore bulls. Six 30-mo-old Nellore bulls (669 ± 65 kg BW) were randomly assigned to four 6-h periods in a Latin Square design such that measurements of each animal cover a 24-h cycle. Meteorological variables (air temperature, relative humidity, local solar irradiance, ultraviolet radiation, wind speed and black globe temperature) were recorded at regular one-minute intervals with an automated weather station...
May 2018: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29797272/development-of-hair-fibres
#12
Duane P Harland, Jeffrey E Plowman
The growth of hairs occurs during the anagen phase of the follicle cycle. Hair growth begins with basement membrane-bound stem cells (mother cells) around the dermal papilla neck which continuously bud off daughter cells which further divide as a transient amplifying population. Division ceases as cell line differentiation begins, which entails changes in cell junctions, cell shape and position, and cell-line specific cytoplasmic expression of keratin and trichohyalin. As the differentiating cells migrate up the bulb, nuclear function ceases in cortex, cuticle and inner root sheath (IRS) layers...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29797270/introduction-to-hair-development
#13
Duane P Harland
The anagen phase of the hair follicle cycle is when the follicle is configured to grow hair. In short hairs (e.g., mouse underhairs and human eye lashes) anagen phase is short, but in the wool of sheep and in human scalp hair anagen is a prolonged state lasting for years. In this chapter we describe the morphological and biological divisions within the anagen follicle.
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29797264/the-follicle-cycle-in-brief
#14
Jeffrey E Plowman, Duane P Harland
This chapter presents a very succinct overview of the cyclic biology of the hair follicle as it transitions from the quiescent telogen stage to the anagen stage in which hairs are actively produced before regressing through the catagen stage to telogen.
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29790053/innovative-sludge-pretreatment-technology-for-impurity-separation-using-micromesh
#15
Xiaojie Mei, Xiaomeng Han, Lili Zang, Zhichao Wu
In order to reduce the impacts on sludge treatment facilities caused by impurities such as fibers, hairs, plastic debris, and coarse sand, an innovative primary sludge pretreatment technology, sludge impurity separator (SIS), was proposed in this study. Non-woven micromesh with pore size of 0.40 mm was used to remove the impurities from primary sludge. Results of lab-scale tests showed that impurity concentration, aeration intensity, and channel gap were the key operation parameters, of which the optimized values were below 25 g/L, 0...
May 23, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29787625/a-bald-statement-current-approaches-to-manipulate-miniaturisation-focus-only-on-promoting-hair-growth
#16
Nikolaos Pantelireis, Claire A Higgins
Hair plays a large part in communication and society with its role changing through time and across cultures. Most people don't leave the house before combing their hair or shaving their beard and for many hair loss or irregular hair growth can have a significant impact on their psychological health. Somewhat unsurprisingly, according to GMR Data today's global hair care industry is worth an estimated $87 Billion in 2018, with hair loss estimated at $2.8 Billion. Considering that no current hair loss related products can completely reverse hair loss, it is reasonable to believe this market could expand significantly with the discovery of a comprehensive therapy...
May 22, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29783073/methylation-analysis-of-cmtm3-and-dusp1-gene-promoters-in-high-quality-brush-hair-in-the-yangtze-river-delta-white-goat
#17
Wang Qiang, Haiyan Guo, Yongjun Li, Jianfei Shi, Xiuyuan Yin, Jingwen Qu
The Yangtze River delta white goat is the only goat breed that produces high-quality brush hair, which is specifically used in top-grade writing brushes. Previous studies have indicated that the CMTM3 and DUSP1 genes are involved in the growth and cycle of high-quality brush hair, and these genes are thought to be involved in the formation of high-quality brush hair traits. In this study, we investigated the relationship between methylation of CMTM3 and DUSP1 and such traits. The results indicated that the relative expression levels of the CMTM3 and DUSP1 genes were higher in non-high-quality brush hair than in high-quality brush hair...
May 18, 2018: Gene
https://www.readbyqxmd.com/read/29769361/convergence-of-biannual-moulting-strategies-across-birds-and-mammals
#18
REVIEW
Roxanne S Beltran, Jennifer M Burns, Greg A Breed
Birds and mammals have developed numerous strategies for replacing worn feathers and hair. Moulting usually occurs on an annual basis; however, moults that take place twice per year (biannual moults) also occur. Here, we review the forces driving the evolution of various moult strategies, focusing on the special case of the complete biannual moult as a convergence of selection pressures across birds and mammals. Current evidence suggests that harsh environmental conditions or seasonality (e.g. larger variation in temperatures) drive evolution of a biannual moult...
May 16, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29766830/impact-of-sphingolipid-mediators-on-determination-of-cochlear-survival-in-ototoxicity
#19
Keiji Tabuchi, Akira Hara
BACKGROUND AND OBJECTIVE: Sphingolipid metabolites, including ceramide, sphingosine, and their phosphorylates (ceramide-1-phosphonate [C1P] and sphingosine-1-phosphate [S1P]), regulate diverse cellular processes including apoptosis, the cell cycle, and cellular differentiation. Recent studies have shown that these sphingolipid metabolites are generated in response to ototoxic agents and play important roles in determining the fate of cochlear hair cells in ototoxic injury. METHODS: This review summarizes the current knowledge on the roles of sphingolipid mediators in cochlear ototoxicity...
May 15, 2018: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/29766701/new-multi-targeting-strategy-in-hair-growth-promotion-in-vitro-and-in-vivo-studies
#20
Barbara Marzani, Daniela Pinto, Elisabetta Sorbellini, Fabio Rinaldi
BACKGROUND: Considering the importance of hair in our modern society and the impact of hair loss, the efforts of researchers are addressed to better understand the mechanisms behind the hair cycle regulation and dysregulation. Because hair loss is multifactorial, differenced and new approaches are required. In particular we addressed our attention to two recently identified targets in hair cycling and growth control: olfactory receptor and autophagy. The aim of the study was to evaluate: the possible pro-autophagic effect of N1-methylspermidine (a spermidine analogue) in vitro and, in a double blind clinical trial, the safety and efficacy of topical daily application of a lotion containing N1-methylspermidine and Sandalore®...
June 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
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