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https://www.readbyqxmd.com/read/29662684/a-comparison-of-combined-oral-contraceptives-containing-chlormadinone-acetate-versus-drospirenone-for-the-treatment-of-acne-and-dysmenorrhea-a-randomized-trial
#1
Unnop Jaisamrarn, Somsook Santibenchakul
Background: Oral contraceptives (OCs), aside from contraceptive efficacy, have been widely known for their non-contraceptive benefits. Different progestogens component of the OCs have been shown to improve the skin, hair, menstrual cycle related disorders and dysmenorrhoeic pain. Thus, we compared the efficacy of OCs containing ethinyl estradiol (EE) and chlormadinone acetate (CMA) versus OCs containing EE and drospirenone (DRSP) for the treatment of acne and dysmenorrhea. Methods: This study was an investigator-blinded, randomized, parallel group study conducted at the Family Planning Clinic, Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand...
2018: Contraception and Reproductive Medicine
https://www.readbyqxmd.com/read/29615452/glutamate-transporter-slc1a3-mediates-inter-niche-stem-cell-activation-during-skin-growth
#2
Bettina Reichenbach, Johanna Classon, Tomomi Aida, Kohichi Tanaka, Maria Genander, Christian Göritz
Tissues contain distinct stem cell niches, but whether cell turnover is coordinated between niches during growth is unknown. Here, we report that in mouse skin, hair growth is accompanied by sebaceous gland and interfollicular epidermis expansion. During hair growth, cells in the bulge and outer root sheath temporarily upregulate the glutamate transporter SLC1A3, and the number of SLC1A3+ basal cells in interfollicular epidermis and sebaceous gland increases. Fate mapping of SLC1A3+ cells in mice revealed transient expression in proliferating stem/progenitor cells in all three niches...
April 3, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29605938/establishment-of-dermal-sheath-cell-line-from-cashmere-goat-and-characterizing-cytokeratin-13-as-its-novel-biomarker
#3
Bing Zhu, Zhili Guo, Muzi Jin, Yujuan Bai, Wenliang Yang, Lihua Hui
OBJECTIVE: To establish a dermal sheath cell line, a dermal papilla cell line and a outer root sheath cell line from Cashmere goat and clarify the similarities and differences among them. RESULTS: We established a dermal sheath cell line, a dermal papilla cell line and a outer root sheath cell line from the pelage skin hair follicles of Cashmere goat. The growth rate of dermal sheath cells was intermediate between that of dermal papilla cells and outer root sheath cells...
March 31, 2018: Biotechnology Letters
https://www.readbyqxmd.com/read/29603400/a-guide-to-studying-human-dermal-adipocytes-in-situ
#4
Carina Nicu, Jennifer Pople, Laura Bonsell, Ranjit Bhogal, David M Ansell, Ralf Paus
Dermal white adipose tissue (DWAT) is a main component of human skin, composed of individual lipid-laden mesenchymal cells known as dermal adipocytes (DAs). Besides their well-known role in lipid storage and release, DAs also promote skin immunity, wound healing and hair follicle cycling and are important players in cutaneous neuro-endocrinology. The ever-growing insights into DWAT functions, albeit mostly in mice, have invited speculation that it may be involved in multiple skin diseases ranging from fibrosis to alopecia and psoriasis, thus designating human DWAT a clinically relevant, but as yet insufficiently investigated skin compartment...
March 30, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29602800/the-microrna-200-family-coordinately-regulates-cell-adhesion-and-proliferation-in-hair-morphogenesis
#5
Jaimee E Hoefert, Glen A Bjerke, Dongmei Wang, Rui Yi
The microRNA (miRNA)-200 (miR-200) family is highly expressed in epithelial cells and frequently lost in metastatic cancer. Despite intensive studies into their roles in cancer, their targets and functions in normal epithelial tissues remain unclear. Importantly, it remains unclear how the two subfamilies of the five-miRNA family, distinguished by a single nucleotide within the seed region, regulate their targets. By directly ligating miRNAs to their targeted mRNA regions, we identify numerous miR-200 targets involved in the regulation of focal adhesion, actin cytoskeleton, cell cycle, and Hippo/Yap signaling...
March 30, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29582573/regulation-of-melanocyte-stem-cell-behavior-by-the-niche-microenvironment
#6
REVIEW
Huirong Li, Ling Hou
Somatic stem cells are regulated by their niches to maintain tissue homeostasis and repair throughout the lifetime of an organism. An excellent example to study stem cell/niche interactions is provided by the regeneration of melanocytes during the hair cycle and in response to various types of injury. These processes are regulated by neighboring stem cells and multiple signaling pathways, including WNT/β-catenin, KITL/KIT, EDNs/EDNRB, TGFβ/TGFβR, α-MSH/MC1R, and Notch signaling. In this review, we highlight recent studies that have advanced our understanding of the molecular crosstalk between melanocyte stem cells and their neighboring cells, which collectively form the niche microenvironment, and we focus on the question of how McSCs/niche interactions shape the responses to genotoxic damages and mechanical injury...
March 26, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29582461/short-anagen-syndrome-case-series-and-literature-review
#7
Kate E Oberlin, Austin J Maddy, María Abril Martínez-Velasco, Norma Elizabeth Vázquez-Herrera, Lawrence A Schachner, Antonella Tosti
BACKGROUND/OBJECTIVES: Short anagen syndrome is a hair cycle disorder usually diagnosed in early childhood and characterized by short hair length due to short duration of the anagen phase. The objective was to review the presentation and demographic characteristics of short anagen syndrome and compare them with the most common differential diagnosis, loose anagen syndrome. METHODS: A retrospective review of eight children with short anagen syndrome was performed at the University of Miami Outpatient Dermatology Clinic...
March 26, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29572801/hair-shaft-growth-in-gelfoam-%C3%A2-histoculture-of-skin-and-isolated-hair-follicles
#8
Robert M Hoffman, Lingna Li, Wenluo Cao
Human scalp skin with abundant hair follicles in various stages of the hair growth cycle was histocultured for up to 40 days on Gelfoam® at the air/liquid interface. The anagen hair follicles within the histoculture scalp skin produced growing hair shafts. Hair follicles could continue their cycle in histoculture; for example, apparent spontaneous catagen induction was observed both histologically and by the actual regression of the hair follicle. In addition, vellus follicles were shown to be viable at day 40 after initiation of culture...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29572789/3d-sponge-matrix-histoculture-an-overview
#9
Robert M Hoffman
Three-dimensional cell culture and tissue culture (histoculture) is much more in vivo-like than 2D culture on plastic. Three-dimensional culture allows investigation of crucial events in tumor biology such as drug response, proliferation and cell cycle progression, cancer cell migration, invasion, metastasis, immune response, and antigen expression that mimic in vivo conditions. Three-dimensional sponge-matrix histoculture maintains the in vivo phenotype, including the formation of differentiated structures of normal and malignant tissues, perhaps due to cells maintaining their natural shape in a sponge-gel matrix such as Gelfoam® ...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29567975/loss-of-idh2-accelerates-age-related-hearing-loss-in-male-mice
#10
Karessa White, Mi-Jung Kim, Chul Han, Hyo-Jin Park, Dalian Ding, Kevin Boyd, Logan Walker, Paul Linser, Zaimary Meneses, Cole Slade, Jonathan Hirst, Katherine Santostefano, Naohiro Terada, Takuya Miyakawa, Masaru Tanokura, Richard Salvi, Shinichi Someya
Isocitrate dehydrogenase (IDH) 2 participates in the TCA cycle and catalyzes the conversion of isocitrate to α-ketoglutarate and NADP+ to NADPH. In the mitochondria, IDH2 also plays a key role in protecting mitochondrial components from oxidative stress by supplying NADPH to both glutathione reductase (GSR) and thioredoxin reductase 2 (TXNRD2). Here, we report that loss of Idh2 accelerates age-related hearing loss, the most common form of hearing impairment, in male mice. This was accompanied by increased oxidative DNA damage, increased apoptotic cell death, and profound loss of spiral ganglion neurons and hair cells in the cochlea of 24-month-old Idh2-/- mice...
March 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29564738/platelet-rich-plasma-therapy-and-reproductive-medicine
#11
EDITORIAL
Adriana Bos-Mikich, Ricardo de Oliveira, Nilo Frantz
Reports on clinical uses of platelet-rich plasma (PRP) have dramatically increased in the last decade. Indications for PRP therapy range from muscle and skeletal injuries to hair re-growth. More recently evidences have shown its positive effects in promoting endometrial and follicular growth and gestation in assisted reproduction cycles. We discuss the putative role of PRP on endometrial receptivity, with a brief history of its applications in research and clinical therapies. Despite its widespread uses in medicine, the mechanisms through which PRP exerts its regenerative effects are only postulated, not based on scientific data...
March 21, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29551177/patient-reported-outcome-assessment-and-objective-evaluation-of-chemotherapy-induced-alopecia
#12
Manon M C Komen, Corina J G van den Hurk, Johan W R Nortier, T van der Ploeg, Carolien H Smorenburg, Jacobus J M van der Hoeven
PURPOSE: Alopecia is one of the most distressing side effects of chemotherapy. Evaluating and comparing the efficacy of potential therapies to prevent chemotherapy-induced alopecia (CIA) has been complicated by the lack of a standardized measurement for hair loss. In this study we investigated the correlation between patient-reported outcome assessments and quantitative measurement with the hair check to assess CIA in clinical practice. METHOD: Scalp cooling efficacy was evaluated by patients by World Health Organisation (WHO) of CIA, Visual Analogue Scale (VAS) and wig use...
April 2018: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29547783/the-plasma-protein-binding-of-the-endogenous-glucocorticosteroids-is-of-vital-importance-for-the-concentrations-in-hair-and-saliva
#13
Aniko Krumbholz, Martin Schönfelder, Hande Hofmann, Detlef Thieme
BACKGROUND: The endogenous glucocorticosteroid cortisol (F) and its metabolite cortisone (E) are known to be involved in stress adaption and anti-inflammatory and immune regulatory effects. The ratios of F to E in the matrices serum, hair and saliva are different. The shift of this ratio by the enzyme activity of 11β-hydroxysteroid-dehydrogenase, which inactivates cortisol, was often discussed. The aim of our study was to calculate the contribution of the plasma protein binding (PPB) to this shift...
February 26, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29547782/a-mixed-composition-particle-highlights-the-formation-mechanism-of-the-weapon-memory-effect-phenomenon
#14
Osnat Israelsohn-Azulay, Yigal Zidon, Tsadok Tsach
A shooting event involved several types of ammunition that were all shot from a single firearm. GSR analysis of samples taken from the suspect's hands, hair and from his clothes was carried out. Mixed compositions particles were found among other GSR particles, attributed to the weapon memory effect. SEM/EDX analysis of these particles highlighted a particle with defined domains containing distinct groups of elements. Some of these elements were absent in the primers mixtures of the ammunition used in the shooting event...
March 6, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29541960/the-role-of-sox9-in-maintaining-the-characteristics-and-pluripotency-of-arbas-cashmere-goat-hair-follicle-stem-cells
#15
Nimantana He, Zhenguo Dong, Dapeng Tai, Hao Liang, Xudong Guo, Ming Cang, Dongjun Liu
In our previous work, we isolated Arbas Cashmere goat hair follicle stem cells (gHFSCs) and explored the pluripotency. In this study, we investigated the expression and putative role of Sox9 in the gHFSCs. Immunofluorescence staining showed that Sox9 is predominantly expressed in the bulge region of the Arbas Cashmere goat hair follicle, and also positively expressed in both nucleus and cytoplasm of the gHFSCs. When the cells were transfected using Sox9-shRNA, cell growth slowed down and the expression of related genes decreased significantly, cell cycle was abnormal, while the expression of terminal differentiation marker loricrin was markedly increased; cells lost the typical morphology of HFSCs; the mRNA and protein expression of gHFSCs markers and stem cell pluripotency associated factors were all significantly decreased; the expression of Wnt signaling pathway genes LEF1, TCF1,c-Myc were significantly changed...
March 14, 2018: Cytotechnology
https://www.readbyqxmd.com/read/29527094/a-discrete-event-simulation-approach-to-identify-rules-that-govern-arbor-remodeling-for-branching-cutaneous-afferents-in-hairy-skin
#16
Hyojung Kang, Rachel L Orlowsky, Gregory J Gerling
In mammals, touch is encoded by sensory receptors embedded in the skin. For one class of receptors in the mouse, the architecture of its Merkel cells, unmyelinated neurites, and heminodes follow particular renewal and remodeling trends over hair cycle stages from ages 4 to 10 weeks. As it is currently impossible to observe such trends across a single animal's hair cycle, this work employs discrete event simulation to identify and evaluate policies of Merkel cell and heminode dynamics. Well matching the observed data, the results show that the baseline model replicates dynamic remodeling behaviors between stages of the hair cycle - based on particular addition and removal polices and estimated probabilities tied to constituent parts of Merkel cells, terminal branch neurites and heminodes...
December 2017: Proceedings of the Winter Simulation Conference
https://www.readbyqxmd.com/read/29511355/real-world-data-on-health-related-quality-of-life-assessment-in-patients-with-breast-cancer-receiving-subcutaneous-trastuzumab
#17
John Syrios, Evelina Pappa, Nikolaos Volakakis, Anastasios Grivas, John Alafis, Sofia Manioudaki, Vasiliki Tzouda, Athanasios Korogiannos, Cleopatra Rapti, Nektarios Koufopoulos, Adamantia Nikolaidou, Eleftheria Kanavou, Athanasios Alexopoulos, Anna Koumarianou
Purpose: Trastuzumab, a humanized anti-human epidermal growth factor receptor 2 (anti-HER2) antibody delivered intravenously, has revolutionized the treatment of patients with breast cancer overexpressing HER2 protein. Recently, a newer subcutaneous formulation was shown to have comparable efficacy to the initial intravenous trastuzumab. In this study, we aimed to evaluate the impact of subcutaneous trastuzumab on the health-related quality of life (HRQoL) of patients diagnosed with early or metastatic HER2-overexpressing breast cancer...
2018: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29477189/adipose-and-hair-function-an-apparent-connection
#18
Nasif Islam, Luis A Garza
Adipose tissue plays essential roles in various aspects of skin physiology, from regulating hair follicle morphogenesis to wound healing. Peroxisome proliferator-activated receptor gamma is important for the maintenance of adipose tissue and has been implicated in some types of hair loss; however, its function during the hair cycle is still unclear. Sardella et al. investigate the role of peroxisome proliferator-activated receptor gamma in hair follicle morphogenesis using a novel global peroxisome proliferator-activated receptor gamma-null mouse...
March 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29466757/quiescent-tissue-stem-cells-evade-immune-surveillance
#19
Judith Agudo, Eun Sook Park, Samuel A Rose, Eziwoma Alibo, Robert Sweeney, Maxime Dhainaut, Koichi S Kobayashi, Ravi Sachidanandam, Alessia Baccarini, Miriam Merad, Brian D Brown
Stem cells are critical for the maintenance of many tissues, but whether their integrity is maintained in the face of immunity is unclear. Here we found that cycling epithelial stem cells, including Lgr5+ intestinal stem cells, as well as ovary and mammary stem cells, were eliminated by activated T cells, but quiescent stem cells in the hair follicle and muscle were resistant to T cell killing. Immune evasion was an intrinsic property of the quiescent stem cells resulting from systemic downregulation of the antigen presentation machinery, including MHC class I and TAP proteins, and is mediated by the transactivator NLRC5...
February 20, 2018: Immunity
https://www.readbyqxmd.com/read/29451559/linking-chromatin-dynamics-cell-fate-plasticity-and-tissue-homeostasis-in-adult-mouse-hair-follicle-stem-cells
#20
Jayhun Lee, Tudorita Tumbar
Cellular plasticity for fate acquisition is associated with distinct chromatin states, which include histone modifications, dynamic association of chromatin factors with the DNA, and global chromatin compaction and nuclear organization. While embryonic stem cell (ESC) plasticity in vitro and its link with chromatin states have been characterized in depth, little is known about tissue stem cell plasticity in vivo , during adult tissue homeostasis. Recently, we reported a distinct globally low level of histone H3 K4/9/27me3 in mouse hair follicle stem cells (HFSCs) during quiescence...
July 2017: Molecular life
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