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https://www.readbyqxmd.com/read/29451559/linking-chromatin-dynamics-cell-fate-plasticity-and-tissue-homeostasis-in-adult-mouse-hair-follicle-stem-cells
#1
Jayhun Lee, Tudorita Tumbar
Cellular plasticity for fate acquisition is associated with distinct chromatin states, which include histone modifications, dynamic association of chromatin factors with the DNA, and global chromatin compaction and nuclear organization. While embryonic stem cell (ESC) plasticity in vitro and its link with chromatin states have been characterized in depth, little is known about tissue stem cell plasticity in vivo , during adult tissue homeostasis. Recently, we reported a distinct globally low level of histone H3 K4/9/27me3 in mouse hair follicle stem cells (HFSCs) during quiescence...
July 2017: Mol Life
https://www.readbyqxmd.com/read/29445029/pantoprazole-an-inhibitor-of-the-organic-cation-transporter-2-does-not-ameliorate-cisplatin-related-ototoxicity-or-nephrotoxicity-in-children-and-adolescents-with-newly-diagnosed-osteosarcoma-treated-with-methotrexate-doxorubicin-and-cisplatin
#2
Elizabeth Fox, Kristin Levin, Yan Zhu, Blair Segers, Naomi Balamuth, Richard Womer, Rochelle Bagatell, Frank Balis
LESSONS LEARNED: Using a randomized crossover design and continuous variables such as change in hearing threshold and biomarkers of acute renal injury as short-term endpoints, it was determined that pantoprazole, an organic cation transporter 2 inhibitor, did not ameliorate cisplatin-associated nephrotoxicity or ototoxicity.Cystatin C is a robust method to estimate glomerular filtration rate in patients with cancer. Using a patient-reported outcome survey, all patients identified tinnitus and subjective hearing loss occurring "at least rarely" after cycle 1, prior to objective high-frequency hearing loss measured by audiograms...
February 14, 2018: Oncologist
https://www.readbyqxmd.com/read/29422543/poly-rc-binding-protein-2-acts-as-a-negative-regulator-of-ires-mediated-translation-of-hr-mrna
#3
Jeong-Ki Kim, Injung Kim, Keonwoo Choi, Jee-Hyun Choi, Eunmin Kim, Hwa-Young Lee, Jongkeun Park, Sungjoo Kim Yoon
During the hair follicle (HF) cycle, HR protein expression is not concordant with the presence of the Hr mRNA transcript, suggesting an elaborate regulation of Hr gene expression. Here we present evidence that the 5' untranslated region (UTR) of the Hr gene has internal ribosome entry site (IRES) activity and this activity is regulated by the binding of poly (rC) binding protein 2 (PCBP2) to Hr mRNA. Overexpression and knockdown of PCBP2 resulted in a decrease in Hr 5' UTR IRES activity and an increase in HR protein expression without changing mRNA levels...
February 9, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29401444/the-competition-between-the-noise-and-shear-motion-sensitivity-of-cochlear-inner-hair-cell-stereocilia
#4
Aritra Sasmal, Karl Grosh
Acoustical excitation of the organ of Corti induces radial fluid flow in the subtectorial space (STS) that excites the hair bundles (HBs) of the sensory inner hair cell of the mammalian cochlea. The inner hair cell HBs are bathed in endolymphatic fluid filling a thin gap in the STS between the tectorial membrane and the reticular lamina. According to the fluctuation dissipation theorem, the fluid viscosity gives rise to mechanical fluctuations that are transduced into current noise. Conversely, the stochastic fluctuations of the mechanically gated channels of the HBs also induce dissipation...
January 23, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29383501/parasites-of-small-indian-mongoose-herpestes-auropunctatus-on-st-kitts-west-indies
#5
Trista Cheng, Brandon Halper, Jennifer Siebert, Luis Cruz-Martinez, Aspinas Chapwanya, Patrick Kelly, Jennifer K Ketzis, Jeffrey Vessell, Liza Köster, Chaoqun Yao
Herpestes auropunctatus, the small Indian mongoose, is an invasive omnivore introduced to the Caribbean, including the island of St. Kitts over 150 years ago. It has played a role in changing native fauna and can carry zoonotic pathogens of public health importance. The aim of the current study was to estimate the prevalence of parasites harbored by mongooses. In total, 87 mongooses trapped from April to July 2015 were examined for parasites using (1) hair plucks (N = 79), ear swabs (N = 79), and general coat and skin examination (N = 87) for mites, ticks, lice, and fleas; (2) dissection of the trachea, bronchi, and lungs for lungworms and flukes (N = 76); (3) a double centrifugation fecal flotation method for parasites of the gastrointestinal tract (N = 75); and (4) PCR of heart homogenates for Toxoplasma gondii (N = 60)...
January 30, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29371649/studies-on-the-proteome-of-human-hair-identification-of-histones-and-deamidated-keratins
#6
Sunil S Adav, Roopa S Subbaiaih, Swat Kim Kerk, Amelia Yilin Lee, Hui Ying Lai, Kee Woei Ng, Siu Kwan Sze, Artur Schmidtchen
Human hair is laminar-fibrous tissue and an evolutionarily old keratinization product of follicle trichocytes. Studies on the hair proteome can give new insights into hair function and lead to the development of novel biomarkers for hair in health and disease. Human hair proteins were extracted by detergent and detergent-free techniques. We adopted a shotgun proteomics approach, which demonstrated a large extractability and variety of hair proteins after detergent extraction. We found an enrichment of keratin, keratin-associated proteins (KAPs), and intermediate filament proteins, which were part of protein networks associated with response to stress, innate immunity, epidermis development, and the hair cycle...
January 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29367194/construction-of-fgf21-knockout-mouse-models-by-the-crispr-cas9-system
#7
Xu Liu, Ping Zhang, Xiao-Feng Zhang, Xing Li, Yu Bai, Ke-Rong Jia, Xiao-Dong Guo, Hao Zhang, Xiao-Yan Ma, Ming Cang, Dong-Jun Liu, Xu-Dong Guo
Fibroblast growth factors (FGFs) are multifunctional signal molecules between cells, regulating the various physiological functions of the organism. FGF21 is a regulatory factor of the FGF family and has been postulated to play important roles in hair follicle development and hair follicle growth cycle. To evaluate the roles of FGF21, we had established a FGF21 knockout mouse model, using the CRISPR/Cas9 technology. We had constructed a FGF21 targeting vector and microinjected it with Cas9 mRNA and gRNA into fertilized ova of FVB mice...
January 20, 2018: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/29361540/unconventional-myosin-viia-promotes-melanoma-progression
#8
Yuqing Liu, Xiaofan Wei, Lizhao Guan, Sidi Xu, Yang Yuan, Danyu Lv, Xiaokun He, Jun Zhan, Yan Kong, Jun Guo, Hongquan Zhang
Unconventional myosin VIIA (Myo7a) is an actin-based motor molecule that normally functions in cochlear hair cells of the inner ear. Mutations of MYO7A/Myo7a have been implicated in inherited deafness in both humans and mice. However, there is limited information about the functions of Myo7a outside of the specialized cells of the ears. Herein, we report a previously-unidentified function of Myo7a by demonstrating that it plays an important role in melanoma progression. We found that silencing Myo7a by RNAi inhibited melanoma cell growth by upregulation of cell cycle regulator p21 and suppressed melanoma cell migration and invasion by downregulation of RhoGDI2 and MMP9...
January 19, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29342156/specialized-attachment-structure-of-the-fish-pathogenic-oomycete-saprolegnia-parasitica
#9
Svetlana Rezinciuc, Jose Vladimir Sandoval-Sierra, Yolanda Ruiz-León, Pieter van West, Javier Diéguez-Uribeondo
The secondary cysts of the fish pathogen oomycete Saprolegnia parasitica possess bundles of long hooked hairs that are characteristic to this economically important pathogenic species. Few studies have been carried out on elucidating their specific role in the S. parasitica life cycle and the role they may have in the infection process. We show here their function by employing several strategies that focus on descriptive, developmental and predictive approaches. The strength of attachment of the secondary cysts of this pathogen was compared to other closely related species where bundles of long hooked hairs are absent...
2018: PloS One
https://www.readbyqxmd.com/read/29331373/establishment-and-characterization-of-five-immortalized-human-scalp-dermal-papilla-cell-lines
#10
Mi Hee Kwack, Jung Min Yang, Gong Hee Won, Moon Kyu Kim, Jung Chul Kim, Young Kwan Sung
Dermal papilla (DP) regulates the growth and cycling of hair follicles. Cultured DP cells are useful for the study of their role in relation to hair growth and regeneration. However, cultivation of human DP cells is tedious and difficult. In addition, cultured DP cells possess a relatively short replicative life span, requiring immortalized human DP cell lines. We previously established an immortalized human DP cell line, SV40T-hTERT-DPC, by introducing human telomerase reverse transcriptase (hTERT) gene into the transformed cell line, SV40T-DPC...
January 10, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29327704/emerging-nonmetabolic-functions-of-skin-fat
#11
REVIEW
Christian F Guerrero-Juarez, Maksim V Plikus
Although the major white adipose depots evolved primarily to store energy, secrete hormones and thermo-insulate the body, multiple secondary depots developed additional specialized and unconventional functions. Unlike any other fat tissue, dermal white adipose tissue (dWAT) evolved a large repertoire of novel features that are central to skin physiology, which we discuss in this Review. dWAT exists in close proximity to hair follicles, the principal appendages of the skin that periodically grow new hairs. Responding to multiple hair-derived signals, dWAT becomes closely connected to cycling hair follicles and periodically cycles itself...
January 12, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29321681/in-vivo-monitoring-of-hair-cycle-stages-via-bioluminescence-imaging-of-hair-follicle-ng2-cells
#12
Yasuhisa Tamura, Kumi Takata, Asami Eguchi, Yosky Kataoka
Hair growth occurs periodically in a cycle that consists of three different phases: growth, regression, and resting. The length of each phase is regulated by both intrinsic and extrinsic factors throughout life, and influenced by physiological and pathological conditions. Elongation of the resting phase and shortening of the growth phase occur during physiological ageing and in baldness, respectively. In vivo discrimination of each phase of the hair cycle can be used to research for regeneration of hair follicles as well as to evaluate the efficacy of hair regrowth treatments in the same individual...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29320989/expression-of-vimentin-in-hair-follicle-growth-cycle-of-inner-mongolian-cashmere-goats
#13
Nai Rile, Zhihong Liu, Lixia Gao, Jingkai Qi, Meng Zhao, Yuchun Xie, Rui Su, Yanjun Zhang, Ruijun Wang, Jie Li, Hongmei Xiao, Jinquan Li
BACKGROUND: The growth of Inner Mongolian Cashmere goat skin hair follicle exhibits a periodic growth pattern. The hair growth cycle is distinguished as telogen, anagen, and catagen stages. The role of vimentin in the growth process of hair follicles is evident. To elucidate the mechanism underlying the vimentin activity in the growth cycle of hair follicles, transcriptome sequencing and liquid chromatography-tandem mass spectrometry were used to obtain the nucleic acid and amino acid sequences of VIIM gene and vimentin...
January 10, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29273100/an-overview-of-the-biology-of-platelet-rich-plasma-and-microneedling-as-potential-treatments-for-alopecia-areata
#14
REVIEW
Lauren C Strazzulla, Lorena Avila, Kristen Lo Sicco, Jerry Shapiro
Platelet-rich plasma and microneedling have been investigated recently as potential therapeutic options for the treatment of hair disorders. Evidence from laboratory studies indicates that these treatments enhance growth factor production that in turn facilitates hair follicle development and cycling. Several small studies and case reports have presented encouraging findings regarding the use of these treatments for alopecia areata. Future investigations will be needed to validate these therapeutic techniques for patients with alopecia areata and further refine which subtypes of the disease these methods are best indicated for...
January 2018: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/29261127/structural-characterization-and-association-of-ovine-dickkopf-1-gene-with-wool-production-and-quality-traits-in-chinese-merino
#15
Fang Mu, Enguang Rong, Yang Jing, Hua Yang, Guangwei Ma, Xiaohong Yan, Zhipeng Wang, Yumao Li, Hui Li, Ning Wang
Dickkopf-1 (DKK1) is an inhibitor of canonical Wnt signaling pathway and regulates hair follicle morphogenesis and cycling. To investigate the potential involvement of DKK1 in wool production and quality traits, we characterized the genomic structure of ovine DKK1, performed polymorphism detection and association analysis of ovine DKK1 with wool production and quality traits in Chinese Merino. Our results showed that ovine DKK1 consists of four exons and three introns, which encodes a protein of 262 amino acids...
December 20, 2017: Genes
https://www.readbyqxmd.com/read/29249248/-what-s-new-in-dermatological-research
#16
P-E Stoebner
This manuscript provides a selection of dermatological research manuscripts published from September 2016 to August 2017. It is not an exhaustive review but rather a selection of manuscripts susceptible to modify the dermatological practice or affording new pathophysiologic mechanisms and new therapeutic approaches. The following areas of interest are concerned: recognition of dermatological images by artificial intelligence, new concepts in atopic dermatitis, wound repair and hair growth cycle. New data concerning melanomagenesis, epidermolysis bullosa simplex and drug eruption are also highlighted...
December 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29215595/the-role-of-vitamin-d-in-non-scarring-alopecia
#17
REVIEW
Agnieszka Gerkowicz, Katarzyna Chyl-Surdacka, Dorota Krasowska, Grażyna Chodorowska
Non-scarring hair loss is a common problem that affects both male and female patients. Since any disturbances in the hair follicle cycle may lead to hair shedding, or alopecia, it is not surprising that the possible role of vitamin D in alopecia was investigated in many studies. Vitamin D has been shown to have many important functions. A growing body of evidence shows that vitamin D and its receptor are responsible for maintaining not only calcium homeostasis but also skin homeostasis. Moreover, vitamin D could also regulate cutaneous innate and adaptive immunity...
December 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29208059/associations-of-the-serum-long-chain-n-3-pufa-and-hair-mercury-with-resting-heart-rate-peak-heart-rate-during-exercise-and-heart-rate-recovery-after-exercise-in-middle-aged-men
#18
Behnam Tajik, Sudhir Kurl, Tomi-Pekka Tuomainen, Kai Savonen, Jyrki K Virtanen
Long-chain n-3 PUFA from fish have been associated with lower risk of CVD. Fish may also contain methylmercury, which may attenuate the inverse associations of the long-chain n-3 PUFA. However, the mechanisms underlying these associations are not fully known. We evaluated the associations of the serum long-chain n-3 PUFA (EPA, DPA and DHA) and hair Hg with resting heart rate (HR), peak HR during cycle ergometer exercise and HR recovery after exercise. A total of 1008 men from the population-based Kuopio Ischaemic Heart Disease Risk Factor Study, aged 42-60 years and free of CVD, were studied...
January 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29200764/various-wavelengths-of-light-emitting-diode-light-regulate-the-proliferation-of-human-dermal-papilla-cells-and-hair-follicles-via-wnt-%C3%AE-catenin-and-the-extracellular-signal-regulated-kinase-pathways
#19
Hong Jin Joo, Kwan Ho Jeong, Jung Eun Kim, Hoon Kang
Background: The human dermal papilla cells (hDPCs) play an important role in regulation of hair cycling and growth. Objective: The aim of this study was to investigate the effect of different wavelengths of light-emitting diode (LED) irradiation on the proliferation of cultured hDPCs and on the growth of human hair follicles (HFs) in vitro. Methods: We examined the effect of LED irradiation on Wnt/β-catenin signaling and mitogen-activated protein kinase (MAPK) pathways in hDPCs...
December 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/29199102/effect-of-repeated-adrenocorticotropic-hormone-administration-on-reproductive-function-and-hair-cortisol-concentration-during-the-estrous-cycle-in-goats
#20
Natsumi Endo, Hiroaki Yamane, Larasati Puji Rahayu, Tomomi Tanaka
Measurement of the cortisol concentration in hair has been used as an index of chronic stress in several species including humans, wildlife and domestic animals. However, how accurately the cortisol concentration in hair reflects the changes in circulating cortisol concentrations has not been well documented. The objective of the present study was to examine the effect of repeated adrenocorticotropic hormone (ACTH) administration on the reproductive function during the estrous cycle and hair cortisol concentrations in goats...
November 30, 2017: General and Comparative Endocrinology
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