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https://www.readbyqxmd.com/read/28634657/longitudinal-perceptions-of-the-side-effects-of-chemotherapy-in-patients-with-gynecological-cancer
#1
Hui-Chun Hsu, Su-Yu Tsai, Shang-Liang Wu, Shiow-Roug Jeang, Mei-Yao Ho, Wen-Shiung Liou, An-Jen Chiang, Tsung-Hsien Chang
PURPOSE: This study aimed to assess the incidence and difference of side effects among six courses of chemotherapy (C/T) in gynecological cancer patients. METHODS: The study period was from Sep. 2010 to Dec. 2011 at the Kaohsiung Veterans General Hospital in Taiwan. The treating protocols, courses, and drugs of C/T in patient were considered according to the different malignant cancers and clinical conditions. The patient data of age, marriage status, education, religion, and experiences of C/T were collected...
June 21, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28630424/characterization-of-slow-cycling-corneal-limbal-epithelial-cells-identifies-putative-stem-cell-markers
#2
R Sartaj, C Zhang, P Wan, Z Pasha, V Guaiquil, A Liu, J Liu, Y Luo, E Fuchs, M I Rosenblatt
In order to identify reliable markers of corneal epithelial stem cells, we employed an inducible transgenic "pulse-chase" murine model (K5Tta × TRE-H2BGFP) to localize, purify, and characterize slow cycling cells in the cornea. The retention of GFP labeling in slowly dividing cells allowed for localization of these cells to the corneal limbus and their subsequent purification by FACS. Transcriptome analysis from slow cycling cells identified differentially expressed genes when comparing to GFP(-) faster-dividing cells...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28627318/effects-of-gamma-rays-on-the-regeneration-of-murine-hair-follicles-in-the-natural-hair-cycle
#3
Kimihiko Sugaya
PURPOSE: This review evaluates the effects of γ-rays on the regeneration of murine hair follicles in the natural hair cycle. A series of studies were performed to investigate this issue, in which the whole bodies of C57BL/10JHir mice in the 1(st) telogen phase of the hair cycle were irradiated with γ-rays. RESULTS: The dermis of the irradiated skin showed a decrease in hair follicle density and induction of curved hair follicles along with the presence of white hairs and hypopigmented hair bulbs in the 2(nd) and 3(rd) anagen phases...
June 19, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28626889/from-basal-cell-morphogenesis-to-the-alopecia-induced-by-hedgehog-inhibitors-connecting-the-dots
#4
REVIEW
C Dessinioti, C Antoniou, A J Stratigos
The deciphering of the hedgehog (Hh) signaling pathway implicated in the tumorigenesis of basal cell carcinoma (BCC), led to the development of targeted drug therapies, e.g. the hedgehog pathway inhibitors (HPI), vismodegib and sonidegib. In the skin, physiologic Hh signaling is activated in growing hair follicles, where it is required for proliferation of the epithelium of hair follicles during morphogenesis and for their postnatal growth. The effects of HPI treatment leading to the regression of BCC and the development of alopecia, underpin the central role of the Hh pathway in BCC formation as well as hair cycling...
June 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28624120/histologic-features-of-chronic-cutaneous-lupus-erythematosus-of-the-scalp-using-horizontal-sectioning-emphasis-on-follicular-findings
#5
Hye Jin Chung, Lynne J Goldberg
BACKGROUND: Chronic cutaneous lupus erythematosus (CCLE) often affects the scalp resulting in scarring alopecia. While histopathologic findings of CCLE have been well described, there is little written on the morphologic changes to the hair follicles in this condition. OBJECTIVE: We aim to determine the histopathologic findings of hair follicles in CCLE of the scalp. METHODS: We conducted a retrospective study of 33 transversely sectioned skin biopsy specimens of CCLE of the scalp at the Skin Pathology Laboratory at Boston University between April 2005 and March 2015...
June 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28607955/wound-healing-protects-against-chemotherapy-induced-alopecia-in-young-rats-via-up-regulating-interleukin-1%C3%AE-mediated-signaling
#6
Olivera Stojadinovic, Tongyu C Wikramanayake, Alexandra C Villasante Fricke, Natalie C Yin, Liang Liang, Eleanor Hinde, Julia Escandon, Marjana Tomic-Canic, David M Ansell, Ralf Paus, Joaquin J Jimenez
Wound healing is a complex process regulated by various cell types and a plethora of mediators. While interactions between wounded skin and the hair follicles (HFs) could induce HF neogenesis or promote wound healing, it remains unknown whether the wound healing-associated signaling milieu can be manipulated to protect against alopecia, such as chemotherapy-induced alopecia (CIA). Utilizing a well-established neonatal rat model of CIA, we show here that skin wounding protects from alopecia caused by several clinically relevant chemotherapeutic regimens, and that protection is dependent on the time of wounding and hair cycle stage...
May 2017: Heliyon
https://www.readbyqxmd.com/read/28602615/pten-mediates-activation-of-core-clock-protein-bmal1-and-accumulation-of-epidermal-stem-cells
#7
Chiara Zagni, Luciana O Almeida, Tarek Balan, Marco T Martins, Luciana K Rosselli-Murai, Petros Papagerakis, Rogerio M Castilho, Cristiane H Squarize
Tissue integrity requires constant maintenance of a quiescent, yet responsive, population of stem cells. In the skin, hair follicle stem cells (HFSCs) that reside within the bulge maintain tissue homeostasis in response to activating cues that occur with each new hair cycle or upon injury. We found that PTEN, a major regulator of the PI3K-AKT pathway, controlled HFSC number and size in the bulge and maintained genomically stable pluripotent cells. This regulatory function is central for HFSC quiescence, where PTEN-deficiency phenotype is in part regulated by BMAL1...
June 5, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28599846/planar-cell-polarity-dependent-and-independent-functions-in-the-emergence-of-tissue-scale-hair-follicle-patterns
#8
Maureen Cetera, Liliya Leybova, Frank W Woo, Michael Deans, Danelle Devenport
Hair follicles of the mammalian epidermis display local order and global alignment, a complex pattern instructed by the core planar cell polarity (PCP) pathway. Here we address the contributions of core PCP genes, Van Gogh-like and Frizzled, to the establishment, local refinement, and global order of embryonic and postnatal hair follicles. We find that, similar to Fz6 mutants, the disordered hair patterns of Vangl2 mutants are refined over time and eventually corrected. In both mutants, we find that tissue-level reorientation occurs through locally coordinated follicle rotation at stereotyped locations...
June 7, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28594472/gel-network-shampoo-formulation-and-hair-health-benefits
#9
Jennifer M Marsh, Mark Brown, Tim Felts, Howard Hutton, Mike Vatter, Shane Whitaker, Fred Wireko, Peter Styczynski, Chuiying Li, Ian Henry
OBJECTIVE: The objective of this work was to create a shampoo formula that contains a stable ordered gel network structure that delivers fatty alcohols inside hair. METHODS: X-ray diffraction (SAXS and WAXS), SEM and DSC have been used to confirm formation of the ordered Lβ gel network with fatty alcohol (cetyl and stearyl alcohol) and an anionic surfactant (SLE1S). Micro autoradiography and extraction methods using GC-MS were used to confirm penetration of fatty alcohols into hair and cyclic fatigue testing was used to measure hair strength...
June 8, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28584752/body-to-scalp-evolving-trends-in-body-hair-transplantation
#10
REVIEW
Kuldeep Saxena, Sandeep S Savant
Follicular unit extraction (FUE) is becoming an increasingly popular method for hair restoration. As FUE leaves behind no linear scars, it is more suitable to harvest from various body areas including beard, chest, and extremities in hirsute individuals. Body hair characteristics such as thickness, length, and hair cycle may not completely match to that of the scalp hair. The techniques of harvesting body hairs are more time consuming, requiring higher degree of skill than regular scalp FUE. Body hair transplantation can be successfully used either alone or in combination with scalp hair in advanced grades of baldness, for improving the cosmetic appearance of hairlines and in scarring alopecia when there is paucity of donor scalp hair...
May 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28580147/the-quantification-of-reproductive-hormones-in-the-hair-of-captive-adult-brown-bears-and-their-application-as-indicators-of-sex-and-reproductive-state
#11
Marc Cattet, Gordon B Stenhouse, David M Janz, Luciene Kapronczai, Joy Anne Erlenbach, Heiko T Jansen, O Lynne Nelson, Charles T Robbins, John Boulanger
Recognizing the potential value of steroid hormone measurements to augment non-invasive genetic sampling, we developed procedures based on enzyme-linked immunoassays to quantify reproductive steroid hormone concentrations in brown bear (Ursus arctos) hair. Then, using 94 hair samples collected from eight captive adult bears over a 2-year period, we evaluated (i) associations between hair concentrations of testosterone, progesterone, estradiol and cortisol; (ii) the effect of collecting by shaving vs. plucking; and (iii) the utility of reproductive hormone profiles to differentiate sex and reproductive state...
2017: Conservation Physiology
https://www.readbyqxmd.com/read/28577456/dna-decontamination-of-fingerprint-brushes
#12
Bianca Szkuta, Roland A H van Oorschot, Kaye N Ballantyne
Genetic profiling of DNA collected from fingerprints that have been exposed to various enhancement techniques is routine in many forensic laboratories. As a result of direct contact with fingermark residues during treatment, there is concern around the DNA contamination risk of dusting fingermarks with fingerprint brushes. Previous studies have demonstrated the potential for cross-contamination between evidentiary items through various mechanisms, highlighting the risk of using the same fingerprint brush to powder multiple surfaces within and between crime-scenes...
May 22, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28574382/dermal-adipose-tissue-in-hair-follicle-cycling-possible-applications-in-alopecia
#13
U Wollina, Naser M Abdel, I Kruglikov
Cross-talk between the hair follicles (HFs) in different stages of their cycling and adjacent adipose tissue is a new important topic which is of both theoretical and practical interest. Objective - to analyze available data on possible interrelationship of dermal adipose tissue and hair follicle cycling. Experimental results obtained in rodents clearly demonstrate that HFs cycling is connected to adjacent dermal adipose tissue. Recently uncovered adipocyte-myofibroblast transition can be significantly involved in miniaturization of HFs and be an important pathophysiological step in androgenetic alopecia...
April 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28572727/organic-effects-of-associating-paclitaxel-with-a-lipid-based-nanoparticle-system-on-a-nonhuman-primate-cebus-apella
#14
Danielle Cristinne Azevedo Feio, Nayara Cristina Lima de Oliveira, Edmundo Luis Rodrigues Pereira, Aleksandra Tiemi Morikawa, José Augusto Pereira Carneiro Muniz, Raquel Carvalho Montenegro, Ana Paula Negreiros Nunes Alves, Patrícia Danielle Lima de Lima, Raul Cavalcante Maranhão, Rommel Rodríguez Burbano
Lipid-based nanoparticle systems have been used as vehicles for chemotherapeutic agents in experimental cancer treatments. Those systems have generally been credited with attenuating the severe toxicity of chemotherapeutic agents. This study aimed to investigate the effects of associating paclitaxel (PTX) with a lipid-based nanoparticle system on a nonhuman primate, Cebus apella, documenting the toxicity as measured by serum biochemistry, which is a detailed analysis of blood and tissue. Eighteen C. apella were studied: three animals were treated with cholesterol-rich nanoemulsion (LDE) only, without PTX, administered intravenously every 3 weeks, during six treatment cycles; six animals were treated with PTX associated with LDE at the same administration scheme, three with lower (175 mg/m(2)) and three with higher (250 mg/m(2)) PTX doses; and six animals were treated with commercial PTX, three with the lower and three with the higher doses...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28566005/solid-state-fermentation-and-composting-as-alternatives-to-treat-hair-waste-a-life-cycle-assessment-comparative-approach
#15
Eva Catalán, Dimitrios Komilis, Antoni Sánchez
One of the wastes associated with leather production in tannery industries is the hair residue generated during the dehairing process. Hair wastes are mainly dumped or managed through composting but recent studies propose the treatment of hair wastes through solid-state fermentation (SSF) to obtain proteases and compost. These enzymes are suitable for its use in an enzymatic dehairing process, as an alternative to the current chemical dehairing process. In the present work, two different scenarios for the valorization of the hair waste are proposed and assessed by means of life-cycle assessment: composting and SSF for protease production...
May 1, 2017: Waste Management & Research
https://www.readbyqxmd.com/read/28556372/plant-plant-interactions-influence-developmental-phase-transitions-grain-productivity-and-root-system-architecture-in-arabidopsis-via-auxin-and-pft1-med25-signaling
#16
Edith Muñoz-Parra, Ramón Pelagio-Flores, Javier Raya-González, Guadalupe Salmerón-Barrera, León Francisco Ruiz-Herrera, Eduardo Valencia-Cantero, José López-Bucio
Transcriptional regulation of gene expression influences plant growth, environmental interactions, and plant-plant communication. Here, we report that population density is a key factor for plant productivity and a major root architectural determinant in Arabidopsis thaliana. When grown in soil at varied densities from 1 to 32 plants, high number of individuals decreased stem growth and accelerated senescence, which negatively correlated with total plant biomass and seed production at the completion of the life cycle...
May 27, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28551652/successful-treatment-of-pituitary-germinoma-with-etoposide-cisplatin-vincristine-methotrexate-and-bleomycin-chemotherapy-without-radiotherapy
#17
Amina Scherz, Katrin Feller, Sabina Berezowska, Vera Genitsch, Martin Zweifel
We report on the case of a 25-year-old man with pituitary germinoma. The patient had noticed polydipsia, reduced sexual function, and loss of body hair. Laboratory investigations confirmed panhypopituitarism including diabetes insipidus. Magnetic resonance imaging of the brain showed a 14×8.4 mm enhancing lesion of the pituitary stalk and histopathology of the neurosurgical biopsy confirmed pituitary germinoma. The patient was treated with 3 cycles of chemotherapy, consisting of 150 mg/m(2) etoposide and 75 mg/m(2) cisplatin, with the administration of intrathecal 12...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28549064/chemomechanical-regulation-of-myosin-ic-cross-bridges-deducing-the-elastic-properties-of-an-ensemble-from-single-molecule-mechanisms
#18
Florian Berger, A J Hudspeth
Myosin Ic is thought to be the principal constituent of the motor that adjusts mechanical responsiveness during adaptation to prolonged stimuli by hair cells, the sensory receptors of the inner ear. In this context myosin molecules operate neither as filaments, as occurs in muscles, nor as single or few molecules, as characterizes intracellular transport. Instead, myosin Ic molecules occur in a complex cluster in which they may exhibit cooperative properties. To better understand the motor's remarkable function, we introduce a theoretical description of myosin Ic's chemomechanical cycle based on experimental data from recent single-molecule studies...
May 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28543886/human-hairless-protein-roles-in-skin-hair-and-emerging-connections-to-brain-and-other-cancers
#19
Anas Maatough, G Kerr Whitfield, Lemlem Brook, David Hsieh, Patricia Palade, Jui-Cheng Hsieh
The mammalian hairless protein (HR) is a 130 kDa nuclear transcription factor that is essential for proper skin and hair follicle function. Previous studies have focused on the role of HR in skin maintenance and hair cycling. However, hairless gene (HR) is also expressed in brain and other tissues, where its role remains poorly understood. HR has been reported to contain functional domains that potentially serve in DNA binding, histone demethylation, nuclear translocation signal, and protein-protein interactions...
May 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28536317/-hair-follicle-stem-cells
#20
Shun Sawatsubashi
The hair follicle is a complex miniorgan of the skin and undergoes cycles of growth(anagen), apoptosis-mediated regression(catagen)and rest(telogen). Regeneration of the new hair shaft dependent on the activation of hair follicle stem cells(HFSCs), harboured in the bulge region. Using a hair follicle model, some molecular players that control the balance between HFSC maintenance and ageing-associated HFSC dysfunction have been identified. Here, we reviewed and discussed the recent findings of molecular characterization of HFSCs biology and pathology...
2017: Clinical Calcium
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