keyword
https://read.qxmd.com/read/38493212/tumor-infiltrating-immune-cells-and-survival-in-head-and-neck-squamous-cell-carcinoma-a-retrospective-computational-study
#1
JOURNAL ARTICLE
Lei Zhang, Wei-Quan Wang, Jun-Hong Chen, Jia Feng, Ya-Zhou Liao, You Zou, Rong Liu
The immune infiltration profiles of the tumor microenvironment have effects on the prognosis of head and neck squamous cell carcinoma (HNSCC). Whereas, HNSCC is a heterogeneous group of tumors, but past work has not taken this into consideration. Herein, we investigate the associations between survival and the function of immune cells in different tumorigenic sites of HNSCC. 1149 samples of HNSCC were collected from publicly accessible databases. Based on gene expression data, CIBERSORTx was applied to determine the proportion of 22 immune cell subpopulations...
March 16, 2024: Scientific Reports
https://read.qxmd.com/read/38493083/performance-of-cone-beam-computed-tomography-cbct-in-comparison-to-conventional-computed-tomography-ct-and-magnetic-resonance-imaging-mri-for-the-detection-of-bone-invasion-in-oral-squamous-cell-cancer-oscc-a-prospective-study
#2
JOURNAL ARTICLE
Anton Straub, Christian Linz, Constantin Lapa, Stefan Hartmann, Alexander C Kübler, Urs D A Müller-Richter, Julian Faber, Thorsten Bley, Joachim Brumberg, Olivia Kertels, Roman C Brands
BACKGROUND: Oral squamous carcinoma (OSCC) is often diagnosed at late stages and bone erosion or invasion of the jawbone is frequently present. Computed tomography (CT) and magnetic resonance imaging (MRI) are known to have high diagnostic sensitivities, specificities, and accuracies in detecting these bone affections in patients suffering from OSCC. To date, the existing data regarding the impact of cone-beam computed tomography (CBCT) have been weak. Therefore, this study aimed to investigate whether CBCT is a suitable tool to detect bone erosion or invasion in patients with OSCC...
March 16, 2024: BMC Oral Health
https://read.qxmd.com/read/38492812/radiation-therapy-quality-assurance-analysis-of-alliance-a021501-preoperative-mfolfirinox-or-mfolfirinox-plus-hypofractionated-radiation-therapy-for-borderline-resectable-adenocarcinoma-of-the-pancreas
#3
JOURNAL ARTICLE
Leila T Tchelebi, Diana Segovia, Koren Smith, Qian Shi, T J Fitzgerald, Michael D Chuong, Tyler J Zemla, Eileen M O'Reilly, Jeffrey Meyerhardt, Eugene J Koay, Jessica Leif, Ardaman Shergill, Matthew Hg Katz, Joseph M Herman
BACKGROUND: Alliance A021501 is the first randomized trial to evaluate stereotactic body radiation therapy (SBRT) for borderline resectable pancreatic ductal adenocarcinoma (PDAC) after neoadjuvant chemotherapy. In this post hoc study, we reviewed the quality of radiation therapy (RT) delivered. METHODS: SBRT (6.6 Gy x 5) was intended, although hypofractionated RT (5 Gy x 5) (HIGRT) was permitted if SBRT specifications could not be met. Institutional credentialing through the National Cancer Institute-funded Imaging and Radiation Oncology Core (IROC) was required...
March 14, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38492046/nursing-and-allied-health-workforce-in-australian-public-rheumatology-departments-is-inadequate-a-cross-sectional-observational-study
#4
JOURNAL ARTICLE
Glen A Whittaker, Catherine L Hill, Linda A Bradbury, Janet R Millner, Harrison Cliffe, Daniel R Bonanno, Sia Kazantzis, Hylton B Menz
Rheumatological conditions are complex and impact many facets of daily life. Management of people with rheumatological conditions can be optimised through multidisciplinary care. However, the current access to nursing and allied health professionals in Australia is unknown. A cross-sectional study of nursing and allied health professionals in Australian public rheumatology departments for adult and paediatric services was conducted. The heads of Australian public rheumatology departments were invited to report the health professionals working within their departments, referral pathways, and barriers to greater multidisciplinary care...
March 16, 2024: Rheumatology International
https://read.qxmd.com/read/38491169/global-oral-health-policies-and-recommendations-for-children-with-special-health-care-needs-and-their-applicability-and-effectiveness-during-the%C3%A2-covid-19-pandemic-a-systematic-review
#5
JOURNAL ARTICLE
Mousumi Goswami, Bhawna Saxena, Shivya Tuli, Bakhtawar Shakil, Supriya Bhatara, Sanjesh Padha
AIM: This systematic review aims to assess effectiveness of oral health policies, recommendations and guidelines in safeguarding oral health of children with special healthcare needs during COVID-19. BACKGROUND: This systematic review evaluated the adaptation of global oral health policies for children with special healthcare needs (SHCN) during the COVID-19 pandemic, to provide evidence-based insights to inform policymakers and healthcare providers amid the ongoing global health crisis...
March 15, 2024: Evidence-based Dentistry
https://read.qxmd.com/read/38491112/picture-analysis-of-billboards-and-infographic-graphics-advertising-covid-19-on-promoting-preventive-behaviors-and-taking-vaccination-against-the-coronavirus-disease-pandemic
#6
JOURNAL ARTICLE
Fereshteh Mohamadpour, Ardalan Askarian, Mehrdad Askarian
Today, advertising science is a tool that helps advertisers to design their advertising to meet the needs of the audience. In this regard, knowing and understanding the audience is one of the most important points that advertisers should pay attention to before advertising in order to better attract the audience. This study has been done with the aim of billboards and infographics analysis related to promoting preventive behaviors and vaccination against the Coronavirus disease pandemic and investigating the opinion of the general adult population of Iran...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38490961/stop-stunting-a-misguided-campaign-by-well-meaning-nutritionists
#7
JOURNAL ARTICLE
Michael Hermanussen, Christiane Scheffler
OBJECTIVE: "Stop stunting" is the central focus of the national Indonesian campaign to improve child health. We provide an autoethnographic statement on the currently practiced strategy that commits 23 ministries and an estimated $3.9 billion per year to coordinating nutrition interventions that are supposed to address the underlying causes of stunting. METHODS: We visited six community health posts (posyandus) in West Timor and in Java and participated in routine child health examinations...
March 15, 2024: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://read.qxmd.com/read/38490942/quantitative-analysis-of-the-protective-performance-of-bicycle-helmet-with-multi-direction-impact-protection-system-in-oblique-impact-tests
#8
JOURNAL ARTICLE
Yong Han, Hao Yang, He Wu, Di Pan, Bing-Yu Wang
PURPOSE: The current study aimed to assess the protective performance of helmets equipped with a multi-directional impact protection system (MIPS) under various oblique impact loads. METHODS: Initially, a finite element model of a bicycle helmet with MIPS was developed based on the scanned geometric parameters of an actual bicycle helmet. Subsequently, the validity of model was confirmed using the KASK WG11 oblique impact test method. Three different impact angles (30°, 45°, and 60°) and 2 varying impact speeds (5 m/s and 8 m/s) were employed in oblique tests to evaluate protective performance of MIPS in helmets, focusing on injury assessment parameters such as peak linear acceleration (PLA) and peak angular acceleration (PAA) of the head...
March 7, 2024: Chinese Journal of Traumatology
https://read.qxmd.com/read/38490776/vibratory-impact-of-3-different-ambulance-suspension-systems-on-the-simulated-neonate-and-health-care-provider-during-normal-driving-conditions
#9
JOURNAL ARTICLE
Trevor Pier, Justin S Misuraca, Maria J Mandt
OBJECTIVE: Patients and health care providers experience varying degrees of vibration during interfacility ground transport. The impact of vibration on term and preterm neonates may result in physiologic instability and increased risk of intracranial hemorrhage, whereas the impact on health care providers has been shown to include an increase in perceived and physiologic stress levels and may contribute to chronic back and neck pain. This study aimed to evaluate 3 common ambulance suspension systems and the corresponding vibratory impact produced during typical interfacility driving conditions on adult caregiver and neonatal patient mannequins...
2024: Air Medical Journal
https://read.qxmd.com/read/38490501/biceps-rerouting-augmentation-technique-restores-biomechanics-improves-healing-and-has-many-advantages-for-repair-of-large-and-massive-rotator-cuff-tears
#10
EDITORIAL
Yang-Soo Kim, Sung-Hyun Cho
The biceps rerouting (BR) augmentation technique has emerged as a useful option for the repair of rotator cuff tears (RCTs) when the torn tendon does not cover the footprint or can only be reduced under excessive tension. BR offers several advantages over traditional methods. It is an all-inside joint procedure, eliminating the need for skin incisions other than those for the arthroscopic portal, thus reducing operative time and infection risk. It does not lead to donor site morbidity, (unlike superior capsular reconstruction...
March 13, 2024: Arthroscopy
https://read.qxmd.com/read/38489823/performance-of-the-impact-and-crash-prognostic-models-for-traumatic-brain-injury-in-a-contemporary-multicenter-cohort-a-track-tbi-study
#11
JOURNAL ARTICLE
John K Yue, Young M Lee, Xiaoying Sun, Thomas A van Essen, Mahmoud M Elguindy, Patrick J Belton, Dana Pisică, Ana Mikolic, Hansen Deng, John H Kanter, Michael A McCrea, Yelena G Bodien, Gabriela G Satris, Justin C Wong, Vardhaan S Ambati, Ramesh Grandhi, Ava M Puccio, Pratik Mukherjee, Alex B Valadka, Phiroz E Tarapore, Michael C Huang, Anthony M DiGiorgio, Amy J Markowitz, Esther L Yuh, David O Okonkwo, Ewout W Steyerberg, Hester F Lingsma, David K Menon, Andrew I R Maas, Sonia Jain, Geoffrey T Manley
OBJECTIVE: The International Mission on Prognosis and Analysis of Clinical Trials in Traumatic Brain Injury (IMPACT) and Corticosteroid Randomization After Significant Head Injury (CRASH) prognostic models for mortality and outcome after traumatic brain injury (TBI) were developed using data from 1984 to 2004. This study examined IMPACT and CRASH model performances in a contemporary cohort of US patients. METHODS: The prospective 18-center Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) study (enrollment years 2014-2018) enrolled subjects aged ≥ 17 years who presented to level I trauma centers and received head CT within 24 hours of TBI...
March 15, 2024: Journal of Neurosurgery
https://read.qxmd.com/read/38489566/linking-type-and-extent-of-head-trauma-to-cavum-septum-pellucidum-in-older-adults-with-and-without-alzheimer-disease-and-related-dementias
#12
JOURNAL ARTICLE
Breton M Asken, Jeremy A Tanner, Lawren Vandevrede, Alexandra Apple, Marianne Chapleau, Leslie S Gaynor, Courtney Lane-Donovan, Steven Lenio, Golnaz Yadollahikhales, Shannon Lee, Eva Gontrum, Marguerite Knudtson, Leonardo Iaccarino, Renaud La Joie, Yann Cobigo, Adam M Staffaroni, Kaitlin B Casaletto, Raquel C Gardner, Lea T Grinberg, Maria Luisa Gorno-Tempini, Howard J Rosen, William W Seeley, Bruce L Miller, Joel Kramer, Gil D Rabinovici
BACKGROUND AND OBJECTIVES: Cavum septum pellucidum (CSP) is a common but nonspecific MRI finding in individuals with prior head trauma. The type and extent of head trauma related to CSP, CSP features specific to head trauma, and the impact of brain atrophy on CSP are unknown. We evaluated CSP cross-sectionally and longitudinally in healthy and clinically impaired older adults who underwent detailed lifetime head trauma characterization. METHODS: This is an observational cohort study of University of California, San Francisco Memory and Aging Center participants (healthy controls [HCs], those with Alzheimer disease or related dementias [ADRDs], subset with traumatic encephalopathy syndrome [TES])...
April 9, 2024: Neurology
https://read.qxmd.com/read/38488300/a-multi-sectoral-community-development-intervention-has-a-positive-impact-on-diet-quality-and-growth-in-school-age-children-in-rural-nepal
#13
JOURNAL ARTICLE
Laurie C Miller, Sumanta Neupane, Neena Joshi, Mahendra Lohani
Poor diet quality (diet diversity and animal-source food [ASF] consumption) during childhood negatively affects growth, development, behaviour and physiologic function in later life. Relatively less is known about the impact of poor diet on the growth of school-age children compared to children <5 years of age, especially in low/middle-income countries. A better understanding of delivery strategies for effective interventions to improve diet and hence growth in school-age children is needed. A 36-month longitudinal controlled impact evaluation in rural Nepal assessed the nutrition and growth of children <5 years of age in families assigned via community clusters to full package intervention (community development, training in nutrition [during pregnancy and for children <5 years] and livestock husbandry), partial package (training only) or control (no inputs)...
March 15, 2024: Maternal & Child Nutrition
https://read.qxmd.com/read/38487814/analyzing-gender-gap-in-agricultural-productivity-evidence-from-ethiopia
#14
JOURNAL ARTICLE
Takele Abdisa, Abule Mehare, Mekonnen B Wakeyo
Women make up more than 50% of the agricultural labor force but contribute less than 30% to agricultural productivity. Agriculture is the main source of livelihood in Ethiopia but by contributes more than 35% to GDP, 90% to forex earnings, and 70% to employment sources. So Improving economic well-being ensuring sustainable development, and reducing poverty is impossible by ignoring the role of women. Consequently, the main objective of the study is to investigate the gender gap in agricultural productivity using national Panel data of 3474 households which were collected in 2017 and 2019 by the Policy Studies Institute for AGP II baseline study and midline evaluation...
March 2024: Journal of agriculture and food research
https://read.qxmd.com/read/38487725/neck-management-in-metastatic-cutaneous-squamous-cell-carcinoma-of-the-head-and-neck
#15
JOURNAL ARTICLE
Ning Xu, Qiang Sun
OBJECTIVE: Optimal neck management remains unclear in head and neck cutaneous squamous cell carcinoma (HNcSCC) with parotid metastasis. Our goal was to compare the impact of different cervical treatments on HNcSCC with parotid metastasis. METHODS: Patients were retrospectively included. The primary outcome variables were regional control (RC) and disease-specific survival (DSS). The impacts of observation, elective neck irradiation (ENI), and elective neck dissection (END) were analyzed using the Cox model and presented as hazard ratios (HRs) and 95% confidence intervals (CIs)...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38486679/symptom-reduction-in-mal-de-d%C3%A3-barquement-syndrome-with-attenuation-of-the-velocity-storage-contribution-in-the-central-vestibular-pathways
#16
JOURNAL ARTICLE
Jun Maruta, Catherine Cho, Theodore Raphan, Sergei B Yakushin
BACKGROUND: The velocity storage mechanism of the central vestibular system is closely associated with the vestibulo-ocular reflex (VOR), but also contributes to the sense of orientation in space and the perception of self-motion. We postulate that mal de débarquement syndrome (MdDS) is a consequence of inappropriate sensory adaptation of velocity storage. The premise that a maladapted velocity storage may be corrected by spatial readaptation of the VOR has recently been translated into the development of the first effective treatment for MdDS...
2024: Front Rehabil Sci
https://read.qxmd.com/read/38486655/presentation-clinical-outcome-and-quality-of-life-of-patients-treated-for-head-and-neck-skin-cancer-at-the-university-college-hospital-ibadan
#17
JOURNAL ARTICLE
Afieharo I Michael, Ebere O Ugwu, Olayinka A Olawoye, Samuel A Ademola, Odunayo M Oluwatosin
INTRODUCTION: Patients with head and neck skin cancer experience adverse functional, psychosocial, and financial impacts as a result of the disease and/or its treatment. This study aimed at evaluating the pattern of presentation, clinical outcomes, and quality of life of patients with head and neck skin cancer. MATERIALS AND METHODS: A retrospective cross-sectional study of patients with head and neck skin cancer presenting to the Department of Plastic, Reconstructive & Aesthetic Surgery of the University College Hospital, Ibadan, from January 2017 to December 2021...
2024: Journal of the West African College of Surgeons
https://read.qxmd.com/read/38486428/paid-family-leave-and-the-fight-against-hunger-evidence-from-new-york
#18
JOURNAL ARTICLE
Jiyoon Kim, Otto Lenhart
We examine the effects of New York's paid family leave (PFL) policy, introduced in January 2018, on food security. While researchers evaluating PFL policies in the past have mostly focused on employment and health outcomes, we believe that an improved understanding of potential impacts on food security is pivotal as it is directly related to the health and well-being of mothers and new-borns during the postnatal months. Our analysis uses two primary data sets-Current Population Survey Food Security Supplement (CPS-FSS) and Panel Study of Income Dynamics...
March 14, 2024: Health Economics
https://read.qxmd.com/read/38486047/structure-activity-relationships-of-serotonergic-5-meo-dmt-derivatives-insights-into-psychoactive-and-thermoregulatory-properties
#19
JOURNAL ARTICLE
Pol Puigseslloses, Núria Nadal-Gratacós, Gabriel Ketsela, Nicola Weiss, Xavier Berzosa, Roger Estrada-Tejedor, Mohammad Nazmul Islam, Marion Holy, Marco Niello, David Pubill, Jordi Camarasa, Elena Escubedo, Harald H Sitte, Raúl López-Arnau
Recent studies have sparked renewed interest in the therapeutic potential of psychedelics for treating depression and other mental health conditions. Simultaneously, the novel psychoactive substances (NPS) phenomenon, with a huge number of NPS emerging constantly, has changed remarkably the illicit drug market, being their scientific evaluation an urgent need. Thus, this study aims to elucidate the impact of amino-terminal modifications to the 5-MeO-DMT molecule on its interactions with serotonin receptors and transporters, as well as its psychoactive and thermoregulatory properties...
March 14, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38485905/unraveling-the-impact-of-blood-transfusion-on-transcription-factors-regulating-t-helper-1-2-17-and-regulatory-t-cells
#20
JOURNAL ARTICLE
Samad Valizadeh, Azita Chegini, Faranak Behnaz, Ali Akbar Pourfatollah, Shahram Samiee, Ronak Karbalaeifar
T helper 1 (TH1) and TH2 lymphocytes are the most important components of the immune system affected by blood transfusion. This study aimed`` to evaluate the effect of blood transfusion on gene expression of transcription factors related to the development of TH1, TH2, TH17 and regulatory T cells (Tregs). In this cross-sectional study, 20 patients diagnosed with abdominal aortic aneurysms requiring surgical repair were studied from January 2018 to August 2020. We utilized real-time PCR to evaluate the expression of transcription factor genes associated with TH1, TH2, TH17, and Treg, namely T-box-expressed-in-T-cells (T-bet), GATA-binding protein 3 (GATA-3), retinoid-related orphan receptor (RORγt), and fork head box protein 3 (Foxp3), respectively...
February 11, 2024: Iranian Journal of Allergy, Asthma, and Immunology
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