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https://www.readbyqxmd.com/read/29346039/evaluation-of-a-french-regional-telemedicine-network-dedicated-to-neurological-emergencies-a-14-year-study
#1
Elisabeth Medeiros de Bustos, Eric Berthier, Didier Chavot, Benjamin Bouamra, Thierry Moulin
BACKGROUND: Equality in healthcare between urban and rural areas is problematic in France. Telemedicine networks are expected to improve equality in expertise assessment. We aimed to evaluate the use and impact of a regional rural French telemedicine network, dedicated to medical and surgical neurological emergencies, on interhospital patient transfers. METHODS: Eight community hospital emergency departments were remotely connected to the only university hospital in Franche-Comté, France...
January 18, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29345578/searching-for-new-targets-and-treatments-in-the-battle-against-squamous-cell-carcinoma-of-the-head-and-neck-with-specific-focus-on-tumours-of-the-tongue
#2
Nicola Sgaramella, Xiaolian Gu, Linda Boldrup, Philip J Coates, Robin Fahraeus, Luigi Califano, Gianpaolo Tartaro, Giuseppe Colella, Lena Norberg Spaak, Adrian Strom, Torben Wilms, Lorenzo Lo Muzio, Giovanni Dell'Aversana Orabona, Mario Santagata, Lotta Loljung, Riccardo Rossiello, Karin Danielsson, Klas Strindlund, Sandra Lillqvist, Karin Nylander
Squamous cell carcinoma of the head and neck, SCCHN, is a heterogeneous group of tumours not only concerning site of origin but also regarding aetiology. The 5-year survival for the whole group of SCCHN tumours has not significantly improved over the last 20-25 years. Apart from tumour spread to lymph nodes, N status, gains and losses of specific chromosomes are the only factors shown to be independent prognostic markers for these tumours. Worldwide an increasing number of people ? 40 years are seen being affected by tongue SCC, the most common tumour within the SCCHN group...
January 16, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29343621/impact-of-stainless-steel-exposure-on-the-oxidation-of-polysorbate-80-in-histidine-placebo-and-active-monoclonal-antibody-formulation
#3
Ganapathy Gopalrathnam, Anant Navanithan Sharma, Steven Witt Dodd, Lihua Huang
Rapid oxidation of polysorbate 80 in histidine buffer was observed upon brief exposure to stainless steel. LC/MS analysis indicates degradation of both polyoxyethylene sorbitan and polyoxyethylene head groups and unsaturated fatty acid chains, with further confirmation by RP-HPLC data. Both Fe2+ and Fe3+ were shown to induce polysorbate 80 oxidation. The degree of oxidation in polysorbate 20 and polysorbate 80 are comparable for the head groups and saturated fatty acid esters. However, the same phenomenon was not observed with placebo or drug product when containing an active at a threshold concentration, formulated in sodium citrate, in combination with histidine and sodium citrate, or with Na2 EDTA...
January 17, 2018: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/29342168/reduction-in-musca-domestica-fecundity-by-dsrna-mediated-gene-knockdown
#4
Neil D Sanscrainte, Hanayo Arimoto, Christy M Waits, Lucy Y Li, Dana Johnson, Chris Geden, James J Becnel, Alden S Estep
House flies (Musca domestica) are worldwide agricultural pests with estimated control costs at $375 million annually in the U.S. Non-target effects and widespread resistance challenge the efficacy of traditional chemical control. Double stranded RNA (dsRNA) has been suggested as a biopesticide for M. domestica but a phenotypic response due to the induction of the RNAi pathway has not been demonstrated in adults. In this study female house flies were injected with dsRNA targeting actin-5C or ribosomal protein (RP) transcripts RPL26 and RPS6...
2018: PloS One
https://www.readbyqxmd.com/read/29342153/the-impact-of-optic-nerve-and-related-characteristics-on-disc-area-measurements-derived-from-different-imaging-techniques
#5
Michael Yapp, George Rennie, Michael P Hennessy, Michael Kalloniatis, Barbara Zangerl
PURPOSE: Optic nerve head (ONH) assessment and its interpretation in healthy patients and those with glaucoma remains a pivotal topic specifically considering rapid advancements in imaging technologies. We undertook a large-scale, mixed cohort, comparative study to assess the correlation of optic disc measurements between different imaging modalities and investigated the impact of patient and disc associated parameters. METHODS: ONH sizes were obtained from one randomly selected eye of each of 209 patients using stereophotography, confocal scanning laser ophthalmoscopy and two different optical coherence tomographers (OCT)...
2018: PloS One
https://www.readbyqxmd.com/read/29340715/postural-control-and-the-relation-with-cervical-sensorimotor-control-in-patients-with-idiopathic-adult-onset-cervical-dystonia
#6
J De Pauw, R Mercelis, A Hallemans, G Van Gils, S Truijen, P Cras, W De Hertogh
Cervical dystonia (CD) is a movement disorder characterized by involuntary muscle contractions leading to an abnormal head posture or movements of the neck. Dysfunctions in somatosensory integration are present and previous data showed enlarged postural sway in stance. Postural control during quiet sitting and the correlation with cervical sensorimotor control were investigated. Postural control during quiet sitting was measured via body sway parameters in 23 patients with CD, regularly receiving botulinum toxin treatment and compared with 36 healthy controls...
January 16, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29339401/the-impact-of-preload-reduction-with-head-up-tilt-testing-on-longitudinal-and-transverse-left-ventricular-mechanics-a-study-utilizing-deformation-volume-analysis
#7
Caroline Schneider, Lynsey Forsythe, John Somauroo, Keith George, David Oxborough
BACKGROUND: Left ventricular (LV) function is dependent on load, intrinsic contractility and relaxation with a variable impact on specific mechanics. Strain (ε) imaging allows the assessment of cardiac function; however, the direct relationship between volume and strain is currently unknown. The aim of this study was to establish the impact of preload reduction through head-up tilt (HUT) testing on simultaneous left ventricular (LV) longitudinal and transverse function and their respective contribution to volume change...
March 2018: Echo Research and Practice
https://www.readbyqxmd.com/read/29338614/the-two-mutations-of-actin-myosin-interface-and-their-effect-on-the-dynamics-structures-and-functions-of-skeletal-muscle-actin
#8
Faeze Sadat Mohajer, Sepideh Parvizpour, Jafar Razmara, Mohd Shahir Shamsir
Congenital myopathy is a broad category of muscular diseases with symptoms appearing at the time of birth. One type of congenital myopathy is Congenital Fiber Type Disproportion (CFTD), a severely debilitating disease. The G48D and G48C mutations in the D-loop and the actin-myosin interface are the two causes of CFTD. These mutations have been shown to significantly affect the structure and function of muscle fibers. To the author's knowledge, the effects of these mutations have not yet been studied. In this work, the power stroke structure of the head domain of myosin and the wild and mutated types of actin were modeled...
January 17, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29338279/the-chondrocoracoideus-muscle-a-rare-anatomical-variant-of-the-pectoral-area
#9
Dionysios Venieratos, Alexandros Samolis, Maria Piagkou, Stergios Douvetzemis, Alexandrina Kourotzoglou, Kontantinos Natsis
OBJECTIVE: The study adds important information regarding the descriptive anatomy of a very rarely reported unilateral chondrocoracoideus muscle (of Wood). Additionally it highlights the concomitant muscular and neural alterations. CASE REPORT: The current case presents the occurrence of a chondrocoracoideus muscle situated left-sided, as an extension of the abdominal portion of the pectoralis major muscle (PM). The chondrocoracoideus coexisted with a contralateral atypical PM, partially blended with the clavicular fibers of the deltoid muscle...
November 2017: Acta Medica Academica
https://www.readbyqxmd.com/read/29336770/limit-crystalloid-resuscitation-after-traumatic-brain-injury
#10
Ara Ko, Megan Y Harada, Galinos Barmparas, Eric J T Smith, Kurtis Birch, Zachary R Barnard, Dorothy A Yim, Eric J Ley
Patients with traumatic brain injury (TBI) are often resuscitated with crystalloids in the emergency department (ED) to maintain cerebral perfusion. The purpose of this study was to evaluate whether crystalloid resuscitation volume impacts mortality in TBI patients. This was a retrospective study of trauma patients with head abbreviated injury scale score ≥2, who received crystalloids during ED resuscitation between 2004 and 2013. Clinical characteristics and volume of crystalloids received in the ED were collected...
December 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29336625/the-clavien-dindo-classification-in-pancreatic-surgery-a-clinical-and-economic-validation
#11
Patrick Téoule, Felix Bartel, Emrullah Birgin, Felix Rückert, Torsten J Wilhelm
BACKGROUND/AIMS: In 2004 P. A. Clavien and D. Dindo published the well-known grading system of postoperative complications. It is established in several surgical disciplines. The aim of this study was to assess its validity in pancreatic surgery. The impact of complication grade on economic resources was investigated as well. METHODS: From a prospective database, we retrospectively evaluated all patients who underwent pancreatic resection between January 2009 and December 2014 at our department...
January 16, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29336127/popularity-and-harms-of-aural-foreign-bodies-a-descriptive-study-of-patients-in-baqiyatallah-university-hospital-tehran-iran
#12
Abolfazl Taheri, Sina Navaei Mehmandari, Mojtaba Shahidi, Hamidreza Mehdizadeh, Seyyed Mohammad Javad Mirlohi, Nasrin Mohammadi Aref, Mahsa Alborzi Avanaki, Mohammad Hossein Khosravi
OBJECTIVE: To evaluate the prevalence of external ear complications among Iranian aural foreign body users attending to otolaryngology clinic of our hospital. METHODS: In this cross-sectional study patients attending to Otolaryngology clinics of Baqiyatallah hospital were enrolled regardless of their age, gender and reason of attending. Patients between 15 and 60 years of age were included in the present study. Those with positive history of chronic ear diseases, ear surgery, congenital ear disorders, trauma to ear or head and neck region or shock wave trauma were excluded from the study...
December 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/29334834/mild-jugular-compression-collar-ameliorated-changes-in-brain-activation-of-working-memory-after-one-soccer-season-in-female-high-school-athletes
#13
Weihong Yuan, Jonathan Dudley, Kim Barber-Foss, Jonathan D Ellis, Staci Thomas, Ryan T Galloway, Christopher DiCesare, James Leach, Janet Adams, Thomas Maloney, Brooke Gadd, David Smith, Jeff Epstein, Dustin R Grooms, Kelsey Logan, David R Howell, Mekibib Altaye, Gregory D Myer
Recent neuroimaging studies have suggested that repetitive sub-concussive head impacts, even after only one sport season, may lead to pre- to post-season structural and functional alterations in male high school football athletes. However, data on female atheletes is limited. In the current investigation, we aimed to (1) assess the longitudinal pre- to post-season changes in fMRI of working memory and working memory performance, (2) quantify the association between the pre- to post-season change in fMRI of working memory and the exposure to head impact and working memory performance, and (3) assess whether wearing a neck collar designed to reduce intracranial slosh via mild compression of the jugular veins can ameliorate the changes in fMRI brain activation observed in the non-collar group after a full soccer season...
January 15, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29334542/medial-buttressing-in-orbital-blowout-fractures
#14
Sathyadeepak Ramesh, Christine Bokman, Hamzah Mustak, Christopher Lo, Robert Goldberg, Daniel Rootman
PURPOSE: To study whether ethmoidectomy predisposes the orbit to medial wall fracture with lesser trauma. METHODS: An interventional cadaver study of 5 heads (10 orbits); the left or right orbit was randomized to undergo endoscopic complete ethmoidectomy with the fellow orbit as control. Fractures were induced with direct globe trauma, and heads underwent CT scanning. Energy to induce fracture, peak orbital pressure at time of fracture, fracture pattern, and volume of herniated tissue were measured and analyzed...
January 12, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29334486/re-poli-et-al-is-the-optic-nerve-head-structure-impacted-by-a-diagnostic-lumbar-puncture-in-humans
#15
Javier García-Montesinos, Francisco J Muñoz-Negrete, Elisabet De Dompablo, Gema Rebolleda
No abstract text is available yet for this article.
January 12, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29334484/reply-garc%C3%A3-a-montesinos-et-al-is-the-optic-nerve-head-structure-impacted-by-a-diagnostic-lumbar-puncture-in-humans
#16
Muriel Poli, Philippe Denis, Eric Sellem, Serge Aho-Glele, Alain M Bron
No abstract text is available yet for this article.
January 12, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29331949/bibliometric-analysis-of-military-trauma-publications-2000-2016
#17
Mark L Vickers, C P Coorey, G J Milinovich, L Eriksson, M Assoum, M C Reade
INTRODUCTION: Bibliometric tools can be used to identify the authors, topics and research institutions that have made the greatest impact in a field of medicine. The aim of this research was to analyse military trauma publications over the last 16 years of armed conflict in order to highlight the most important lessons that have translated into civilian practice and military doctrine as well as identify emerging areas of importance. METHODS: A systematic search of research published between January 2000 and December 2016 was conducted using the Thompson Reuters Web of Science database...
January 13, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29330955/intrinsic-constraints-on-the-diversification-of-neotropical-cichlid-adductor-mandibulae-size
#18
Jessica Arbour, Hernán López-Fernández
The diversification of functional traits may be constrained by intrinsic factors, such as structural, mechanical, developmental, or physiological limitations. We explored the biomechanical and constructional constraints on the size of the major jaw closing muscles, the adductor mandibulae complex (AM), in a diverse clade of freshwater fish - the Neotropical cichlids. Using phylogenetic comparative methods, we contrasted patterns of size variation and diversification rates of three AM divisions with variables describing head size and biomechanical coefficients describing force and velocity transmission...
February 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29330861/validity-evidence-as-a-key-marker-of-quality-of-technical-skill-assessment-in-otl-hns
#19
Mathilde Labbé, Meredith Young, Lily H P Nguyen
OBJECTIVE: Quality monitoring of assessment practices should be a priority in all residency programs. Validity evidence is one of the main hallmarks of assessment quality and should be collected to support the interpretation and use of assessment data. Our objective was to identify, synthesize, and present the validity evidence reported supporting different technical skill assessment tools in otolaryngology-head and neck surgery (OTL-HNS). METHODS: We performed a secondary analysis of data generated through a systematic review of all published tools for assessing technical skills in OTL-HNS (n = 16)...
January 13, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29330718/spect-ct-adds-distinct-lymph-node-basins-and-influences-radiologic-findings-and-surgical-approach-for-sentinel-lymph-node-biopsy-in-head-and-neck-melanoma
#20
Becky B Trinh, Brandon C Chapman, Ana Gleisner, Jennifer J Kwak, Rustain Morgan, Martin D McCarter, Csaba Gajdos, Nicole Kounalakis
BACKGROUND: Planar lymphoscintigraphy (PL) has a lower detection rate of sentinel lymph nodes (SLNs) in head and neck melanoma compared with other sites. We assessed situations when single-photon emission computed tomography/computed tomography (SPECT/CT) identified nodes not seen by PL. We also evaluated the impact of SPECT/CT on surgical approach and oncologic outcomes. METHODS: Patients who underwent SLN biopsy (SLNB) for head and neck melanoma with PL and SPECT/CT between November 2011 and December 2016 were included...
January 12, 2018: Annals of Surgical Oncology
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