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https://www.readbyqxmd.com/read/27913177/effect-of-trunnion-roughness-and-length-on-the-modular-taper-junction-strength-under-typical-intraoperative-assembly-forces
#1
S Y Jauch-Matt, A W Miles, H S Gill
Modular hip implants are at risk of fretting-induced postoperative complications most likely initiated by micromotion between adjacent implant components. A stable fixation between ball head and stem-neck taper is critical to avoid excessive interface motions. Therefore, the aim of this study was to identify the effect of trunnion roughness and length on the modular taper strength under typical intraoperative assembly forces. Custom-made Titanium trunnions (standard/mini taper, smooth/grooved surface finish) were assembled with modular Cobalt-chromium heads by impaction with peak forces ranging from 2kN to 6kN...
November 29, 2016: Medical Engineering & Physics
https://www.readbyqxmd.com/read/27913065/hpv-status-cancer-stem-cell-marker-expression-hypoxia-gene-signatures-and-tumour-volume-identify-good-prognosis-subgroups-in-patients-with-hnscc-after-primary-radiochemotherapy-a-multicentre-retrospective-study-of-the-german-cancer-consortium-radiation-oncology
#2
Annett Linge, Fabian Lohaus, Steffen Löck, Alexander Nowak, Volker Gudziol, Chiara Valentini, Cläre von Neubeck, Martin Jütz, Inge Tinhofer, Volker Budach, Ali Sak, Martin Stuschke, Panagiotis Balermpas, Claus Rödel, Anca-Ligia Grosu, Amir Abdollahi, Jürgen Debus, Ute Ganswindt, Claus Belka, Steffi Pigorsch, Stephanie E Combs, David Mönnich, Daniel Zips, Frank Buchholz, Daniela E Aust, Gustavo B Baretton, Howard D Thames, Anna Dubrovska, Jan Alsner, Jens Overgaard, Mechthild Krause, Michael Baumann
OBJECTIVE: To investigate the impact of the tumour volume, HPV status, cancer stem cell (CSC) marker expression and hypoxia gene signatures, as potential markers of radiobiological mechanisms of radioresistance, in a contemporary cohort of patients with locally advanced head and neck squamous cell carcinoma (HNSCC), who received primary radiochemotherapy (RCTx). MATERIALS AND METHODS: For 158 patients with locally advanced HNSCC of the oral cavity, oropharynx or hypopharynx who were treated at six DKTK partner sites, the impact of tumour volume, HPV DNA, p16 overexpression, p53 expression, CSC marker expression and hypoxia-associated gene signatures on outcome of primary RCTx was retrospectively analyzed...
November 29, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27910469/the-fast-reciprocating-magnetic-probe-system-on-the-j-text-tokamak
#3
Fuming Li, Zhipeng Chen, Ge Zhuang, Hai Liu, Lizhi Zhu
The fast reciprocating magnetic probe (FRMP) system is newly developed on the Joint Texas Experimental Tokamak (J-TEXT) to measure the local magnetic fluctuations at the plasma edge. The magnetic probe array in the FRMP consists of four 2-dimensional magnetic probes arranged at different radial locations to detect local poloidal and radial magnetic fields. These probes are protected by a graphite and boron nitride casing to improve the frequency response of each probe; they are mounted on the head of a movable rod, which is oriented along radial direction at the top of the torus...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27909582/ebola-research-funding-a-systematic-analysis-1997-2015
#4
Joseph Ra Fitchett, Amos Lichtman, Damilola T Soyode, Ariel Low, Jimena Villar de Onis, Michael G Head, Rifat Atun
BACKGROUND: The latest outbreak of Ebola in West Africa overwhelmed the affected countries, with the impact on health extending far beyond Ebola-related deaths that have exceeded 11 000. The need to promptly mobilise resources to control emerging infections is widely recognized. Yet, data on research funding for emerging infections remains inadequately documented. METHODS: We defined research investment as all funding flows for Ebola and/or Marburg virus from 1997 to April 2015 whose primary purpose was to advance knowledge and new technologies to prevent or cure disease...
December 2016: Journal of Global Health
https://www.readbyqxmd.com/read/27908072/perceptual-attributes-for-the-comparison-of-head-related-transfer-functions
#5
Laurent S R Simon, Nick Zacharov, Brian F G Katz
The benefit of using individual head-related transfer functions (HRTFs) in binaural audio is well documented with regards to improving localization precision. However, with the increased use of binaural audio in more complex scene renderings, cognitive studies, and virtual and augmented reality simulations, the perceptual impact of HRTF selection may go beyond simple localization. In this study, the authors develop a list of attributes which qualify the perceived differences between HRTFs, providing a qualitative understanding of the perceptual variance of non-individual binaural renderings...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27904726/the-influence-of-arthroscopic-remplissage-for-engaging-hill-sachs-lesions-combined-with-bankart-repair-on-redislocation-and-shoulder-function-compared-with-bankart-repair-alone
#6
Sang-Hun Ko, Jae-Ryong Cha, Chae-Chil Lee, Il-Yeong Hwang, Chang-Gyu Choe, Min-Seok Kim
BACKGROUND: Recurrence of glenohumeral dislocation after arthroscopic Bankart repair can be associated with a large osseous defect in the posterosuperior part of the humeral head. Our hypothesis is that remplissage is more effective to prevent recurrence of glenohumeral instability without a severe motion deficit. METHODS: Engaging Hill-Sachs lesions were observed in 48 of 737 patients (6.5%). Twenty-four patients underwent arthroscopic Bankart repair combined with remplissage (group I) and the other 24 patients underwent arthroscopic Bankart repair alone (group II)...
December 2016: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/27904516/serum-pregnancy-associated-plasma-protein-a-levels-in-the-first-second-and-third-trimester-of-pregnancy-relation-to-newborn-anthropometric-parameters-and-maternal-tobacco-smoking
#7
Magdalena Chełchowska, Joanna Gajewska, Joanna Mazur, Jadwiga Ambroszkiewicz, Tomasz M Maciejewski, Jerzy Leibschang
INTRODUCTION: The purpose of this study was to evaluate the associations of the first, second and third trimester serum pregnancy-associated plasma protein A (PAPP-A) concentrations with neonatal anthropometric parameters. The effect of tobacco smoking during pregnancy on PAPP-A level was also studied. MATERIAL AND METHODS: One hundred and fifty healthy pregnant women were divided into smoking and tobacco-abstinent groups. Serum PAPP-A level was measured with the KRYPTOR rapid random-access immunoassay analyzer...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27904451/the-ratio-of-weight-loss-to-planning-target-volume-significantly-impacts-setup-errors-in-nasopharyngeal-cancer-patients-undergoing-helical-tomotherapy-with-daily-megavoltage-computed-tomography
#8
Wei-Hsien Hou, Chun-Wei Wang, Chiao-Ling Tsai, Feng-Ming Hsu, Jason Chia-Hsien Cheng
BACKGROUND: Changes in head and neck anatomy during radiation therapy (RT) produce setup uncertainties of nasopharyngeal cancer (NPC) irradiation. We retrospectively analyzed image guidance data to identify clinical predictors of setup errors. PATIENTS AND METHODS: The data of 217 NPC patients undergoing definitive RT on a helical tomotherapy (HT) unit were analyzed. Factors including tumor stage, body mass index, weight loss, and planning target volume (PTV) were assessed as predictors of daily megavoltage computed tomography (MVCT) setup displacements, which were automatically registered using software...
December 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27902671/prehospital-transport-for-pediatric-trauma-a-comparison-of-private-transport-and-emergency-medical-services
#9
Yea-Chyi Lin, York Tien Lee, Jasmine Xun Yi Feng, Li Wei Chiang, Shireen Anne Nah
OBJECTIVES: We describe the demographics of pediatric patients with trauma transferred using private transport (PT) versus emergency medical services (EMS) and evaluate the potential impact on their treatment and outcome. METHODS: We accessed data from our national trauma registry, a prospectively collected database. Data were extracted on all patients with trauma admitted to our institution between January 2011 and June 2013, with injury severity score (ISS) higher than 8...
November 29, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27900145/the-sensitivity-and-specificity-of-clinical-measures-of-sport-concussion-three-tests-are-better-than-one
#10
Jacob E Resch, Cathleen N Brown, Julianne Schmidt, Stephen N Macciocchi, Damond Blueitt, C Munro Cullum, Michael S Ferrara
CONTEXT: A battery of clinical measures of neurocognition, balance and symptoms has been recommended for the management of sport concussion (SC) but is based on variable evidence. OBJECTIVE: To examine the sensitivity and specificity of a battery of tests to assess SC in college athletes. DESIGN: Cross-sectional. SETTING: Research laboratory. PATIENTS OR OTHER PARTICIPANTS: Division 1 athletes diagnosed with a SC (n=40) who were 20...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27899112/a-comparison-of-intimate-partner-violence-and-associated-physical-injuries-between-cohabitating-and-married-women-a-5-year-medical-chart-review
#11
Janet Yuen-Ha Wong, Anna Wai-Man Choi, Daniel Yee-Tak Fong, Edmond Pui Hang Choi, John Kit-Shing Wong, Fung Ling So, Chu-Leung Lau, Chak-Wah Kam
BACKGROUND: Cohabitation, referring to a co-residential romantic relationship between two intimate partners without a marriage license, has become widely accepted in contemporary societies. It has been found that cohabitating women have a higher risk of experiencing intimate partner violence (IPV) than married women. However, as yet, no studies have investigated the level and pattern of IPV-associated physical injuries and its mental health impact on cohabitating women. Therefore, we aim to compare IPV-associated physical injuries between cohabitating and married women by conducting a review of 5-year medical records from the emergency departments of two major public hospitals in Hong Kong...
November 29, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27898190/primary-ewing-s-sarcoma-of-the-sinonasal-tract-in-adults-a-challenging-disease
#12
Davide Lombardi, Davide Mattavelli, Luca O Redaelli De Zinis, Remo Accorona, Maria L Morassi, Fabio Facchetti, Vittorio Ferrari, Davide Farina, Rossella Bertulli, Piero Nicolai
BACKGROUND: Sinonasal localization of Ewing's sarcoma in adults is an exceedingly rare event. METHODS: The clinical records of 5 patients with primary sinonasal Ewing's sarcoma treated from 1992 to 2012 were retrospectively analyzed. All pathologic slides were reviewed by 2 experienced pathologists. All patients underwent multimodality treatments. RESULTS: Median age was 36 years (range, 25-52 years). At referral, 2 patients had the original diagnosis changed by review of the histologic slides...
November 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/27896468/evaluation-of-major-trauma-in-elderly-patients-a%C3%A2-single-trauma-center-analysis
#13
Samo Kocuvan, Drago Brilej, Domen Stropnik, Rolf Lefering, Radko Komadina
BACKGROUND: The objective of the study was to gather information about elderly major trauma patients admitted to one particular Slovenian trauma centre in Celje and examine this group of polytrauma patients, specifically with respect to mechanisms of injury, injury severity and distribution of injuries. Further on, to identify morbidity and mortality rates and compare these to the younger population and, finally, to determine the factors that have the most impact on treatment results...
November 28, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27895714/early-detection-and-personalized-treatment-in-oral-cancer-the-impact-of-omics-approaches
#14
REVIEW
Ilda Patrícia Ribeiro, Leonor Barroso, Francisco Marques, Joana Barbosa Melo, Isabel Marques Carreira
BACKGROUND: Oral cancer is one of the most common malignant lesions of the head and neck. This cancer is an aggressive and lethal disease with no significant improvements in the overall survival in the last decades. Moreover, the incidence of oral HPV-positive tumors is rising, especially in young people. This oral neoplasm develops through numerous molecular imbalances that affect key genes and signaling pathways; however, the molecular mechanisms involved in the pathogenesis and progression of oral tumors are still to be fully determined...
2016: Molecular Cytogenetics
https://www.readbyqxmd.com/read/27893451/rotating-and-translating-anthropomorphic-head-voxel-models-to-establish-an-horizontal-frankfort-plane-for-dental-cbct-monte-carlo-simulations-a-dose-comparison-study
#15
A Stratis, G Zhang, R Jacobs, R Bogaerts, H Bosmans
In order to carry out Monte Carlo (MC) dosimetry studies, voxel phantoms, modeling human anatomy, and organ-based segmentation of CT image data sets are applied to simulation frameworks. The resulting voxel phantoms preserve patient CT acquisition geometry; in the case of head voxel models built upon head CT images, the head support with which CT scanners are equipped introduces an inclination to the head, and hence to the head voxel model. In dental cone beam CT (CBCT) imaging, patients are always positioned in such a way that the Frankfort line is horizontal, implying that there is no head inclination...
December 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27893005/transforming-head-and-neck-surgeon-into-thyroid-expert-the-2016-hayes-martin-lecture
#16
Ashok R Shaha
With the rapid rise in the incidence of thyroid cancer, the number of thyroidectomies has increased remarkably in the last 10 years. Thyroidectomy accounts for approximately 40% of the workload in head and neck fellowship. The decision making in thyroid surgery is quite complex, especially when patients present with recurrent or advanced thyroid cancer. The complications of thyroid surgery can be very serious in relation to quality of life. Some of these complications can be avoided with meticulous surgical technique...
November 17, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27892728/a-phase-i-ii-study-of-nab-paclitaxel-cisplatin-and-cetuximab-with-concurrent-radiation-therapy-for-locally-advanced-squamous-cell-cancer-of-the-head-and-neck
#17
Stephen G Chun, Randall Hughes, Baran D Sumer, Larry L Myers, John M Truelson, Saad A Khan, Tsung-Wei Ma, Yang Xie, John S Yordy, Susan Cooley, Jean Wu, Hak Choy, Lucien A Nedzi
Nab-paclitaxel might impact efficacy of radiation for head and neck (H&N) cancer. Nab-paclitaxel, cisplatin, cetuximab, and radiation were evaluated in patients with locally advanced head and neck cancer in this phase I/II trial. Median follow-up was 24 months for 34 patients. The maximum tolerated dose of nab-paclitaxel was 20 mg/m(2) with 20 mg/m(2) cisplatin and 250 mg/m(2) cetuximab. The 2-year progression-free survival (PFS) was 60% (95% confidence interval (CI) 0.42, 0.78), local control 71% (95% CI 0...
November 28, 2016: Cancer Investigation
https://www.readbyqxmd.com/read/27891785/editorial-brain-malformation-surveillance-in-the-zika-era
#18
EDITORIAL
Edwin Trevathan
The current surveillance systems for congenital microcephaly are necessary to monitor the impact of Zika virus (ZIKV) on the developing human brain, as well as the ZIKV prevention efforts. However, these congenital microcephaly surveillance systems are insufficient. Abnormalities of neuronal differentiation, development and migration may occur among infants with normal head circumference who have intrauterine exposure to ZIKV. Therefore, surveillance for congenital microcephaly does not ascertain many of the infants seriously impacted by congenital ZIKV infection...
November 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27890566/management-of-interruptions-to-fractionated-radiotherapy-treatments-four-and-a-half-years-of-experience
#19
J M de la Vega, B Ríos, J Torres Del Río, R Guerrero, I Castillo, D Guirado
BACKGROUND AND PURPOSE: The study objective was to report our four-and-a half years experience (March 1 2011-August 15 2015) of a program to manage interruptions in fractionated radiotherapy treatments. METHODS: A program was developed, based on a specific database, to manage treatment interruptions. Benefits of the program were analyzed in reference to previously published data. Analysis was also performed of two measures to reduce OTT prolongation and improve treatment outcomes: working on public holidays and conducting treatment unit maintenance on Saturdays...
November 24, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27889306/return-to-sporting-activity-after-total-hip-arthroplasty-a-survey-of-members-of-the-british-hip-society
#20
Benjamin M Bradley, Stephen J Moul, Fintan J Doyle, Matthew J Wilson
BACKGROUND: Total hip arthroplasty is increasingly performed in younger, more active patients. Thirty-five percent of patients are involved in sports preoperatively, and a desire to return to sporting activity is now a major expectation. Sporting activity potentially risks premature failure of the implant, and there is no consensus or guidelines among British or European surgeons performing total hip arthroplasty in sporting patients. METHODS: The current practice of British Hip Society members was explored through a Web-based survey...
September 28, 2016: Journal of Arthroplasty
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