Neng Jin, Jin Wu, Shuming Ye, Jing Xue, Tao Meng, Liang Hu, Shangshang Jiang, Hanyang Xu, Yue Yu, Danyou Hu, Guiyang Zhang
Hypoxia, chronic inflammation, and elevated reactive oxygen species (ROS) production induced by hyperglycemia pose formidable challenges to the healing of diabetic chronic wounds, often resulting in impaired recovery. Currently, sustainable and eco-friendly therapeutic approaches targeting this multifaceted problem remain uncharted. Herein, we develop a unique three-functional covalent organic framework (COF)-modified microalgae gel designed for the preparation and treatment of chronic diabetic wounds. The gel comprises an oxygen-releasing basic fibroblast growth factor (bFGF) microalgae matrix, augmented by an ROS-responsive COF...
April 2, 2024: ACS Applied Materials & Interfaces