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Chronic wound care treatments

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https://www.readbyqxmd.com/read/28635188/the-financial-and-quality-of-life-cost-to-patients-living-with-a-chronic-wound-in-the-community
#1
Suzanne Kapp, Nick Santamaria
Chronic wounds are associated with financial and personal costs. The system level expense associated with chronic wounds has been established, however, the out-of-pocket cost incurred by individuals who self-fund has not been the focus of extensive investigation. Recently, there has been renewed interest in evaluating quality of life, in line with the shift to patient enablement and self-care in chronic disease management. The objectives of this research were to describe the out-of-pocket wound treatment costs and the quality of life of people who have chronic wounds...
June 20, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28616815/-prevention-of-nosocomial-infections-and-antibiotic-resistance-in-nursing-homes
#2
REVIEW
Markus Bleckwenn, Judith Hammerschmidt, Claudia Rösing, Manuela Klaschik
BACKGROUND: Nosocomial infections and multidrug-resistant organisms are an increasing problem in nursing homes worldwide; therefore, new approaches for infection control need to be developed. OBJECTIVES: This article gives an overview of infections in nursing homes, their medical treatment and previous measures for infection prevention. MATERIALS AND METHODS: The article is based on a selective literature search including the literature database PubMed...
June 14, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28612149/35-year-experience-with-surgical-treatment-of-hidradenitis-suppurativa
#3
Richard E Burney
BACKGROUND: Hidradenitis suppurativa is a painful and disfiguring chronic inflammatory condition affecting both men and women. Medical treatments, such as antibiotics and immunosuppressive agents, are often ineffective. Over time, patients can suffer from recurrent abscesses, chronic purulent drainage, scarring, and contractures that can only be corrected by surgical excision. There is no agreement, however, on the best way for the surgeon to manage this condition. The purpose of this review is to describe the results of surgical treatment of this condition in a large cohort of patients managed by local excision of hidradenitis, healing by secondary intention and reoperation as needed...
June 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28597990/temporal-dynamics-of-relative-abundances-and-bacterial-succession-in-chronic-wound-communities
#4
Craig D Tipton, Marilyn E Mathew, Richard A Wolcott, Randall D Wolcott, Tigga Kingston, Caleb D Phillips
Polymicrobial bacterial infection is an important factor contributing to wound chronicity. Consequently, clinicians frequently adopt a biofilm-based wound care approach, in which wounds are treated utilizing DNA sequencing information about microbial communities. While more successful than treatment not using community information, there is little information about temporal dynamics of wound communities and optimal approaches over the course of treatment. To characterize these dynamics, temporal analysis over three sampling points was conducted for 167 chronic wounds...
June 8, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28594320/silver-containing-foam-dressings-with-safetac-a-review-of-the-scientific-and-clinical-data
#5
Phil Davies, Sara McCarty, Kristina Hamberg
Background Topical antimicrobials, such as silver dressings, are progressively being used alongside systemic antibiotics to provide adjunctive, antimicrobial therapy to wounds that are clinically infected or at risk of infection. To help improve wound management, dressings that use Safetac soft silicone technology in combination with a silver-impregnated foam dressing material were developed by Mölnlycke Health Care (Gothenburg, Sweden). The range comprises Mepilex Ag, Mepilex Border Ag and Mepilex Transfer Ag...
June 1, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28576257/management-of-the-chronic-burn-wound
#6
REVIEW
Stephen Tyler Elkins-Williams, William A Marston, Charles Scott Hultman
This article reviews the current evidence in using hyperbaric oxygen therapy (HBOT) in burn wounds. There is also separate consideration of diabetic foot burns and a protocol for use of HBOT in a specific case. The challenges of using HBOT in an acute burn care setting are reviewed. Next the pathophysiology of Marjolin ulcers is reviewed. The current thinking in diagnosis, treatment, and prevention of Marjolin ulcers is discussed. Finally, a background in using topical growth factors (tGF) is provided, followed by a summary of the current evidence of tGF in burn wounds...
July 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28576256/negative-pressure-wound-therapy-for-burns
#7
REVIEW
Neel A Kantak, Riyam Mistry, David E Varon, Eric G Halvorson
Negative pressure wound therapy (NPWT) has become a widely used treatment for acute and chronic wounds. NPWT is indicated for a variety of complex wounds, and some studies validate its use for certain aspects of burn care. Although further research is needed to explore the benefits for burns, NPWT has proven beneficial in its use as a dressing that bolsters skin grafts, promotes integration of bilaminate dermal substitutes, promotes re-epithelialization of skin graft donor sites, and potentially reduces the zone of stasis...
July 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28544150/a-randomized-clinical-trial-of-a-human-acellular-dermal-matrix-demonstrated-superior-healing-rates-for-chronic-diabetic-foot-ulcers-over-conventional-care-and-an-active-acellular-dermal-matrix-comparator
#8
Shawn Cazzell, Dean Vayser, Hau Pham, Jodi Walters, Alexander Reyzelman, Brian Samsell, Kimberly Dorsch, Mark Moore
This study compared the efficacy and safety of a human acellular dermal matrix (ADM), D-ADM, with a conventional care arm and an active comparator human ADM arm, GJ-ADM, for the treatment of chronic diabetic foot ulcers. The study design was a prospective, randomized controlled trial that enrolled 168 diabetic foot ulcer subjects in 13 centers across 9 states. Subjects in the ADM arms received one application but could receive one additional application of ADM if deemed necessary. Screen failures and early withdrawals left 53 subjects in the D-ADM arm, 56 in the conventional care arm, and 23 in the GJ-ADM arm (2:2:1 ratio)...
May 24, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28537645/use-of-an-ovine-collagen-dressing-with-intact-extracellular-matrix-to-improve-wound-closure-times-and-reduce-expenditures-in-a-us-military-veteran-hospital-outpatient-wound-center
#9
Daniel T Ferreras, Sean Craig, Rebecca Malcomb
A novel, comprehensive decision-making and treatment algorithm was established within a US government-run military veteran hospital in an attempt to standardize the process of outpatient wound care and streamline costs. All patients were systematically evaluated and treated using the comprehensive algorithm over a span of nine months. After three months of adherence to the algorithm, the algorithm was modified to include ovine-based collagen extracellular matrix (CECM) dressings as a first-line conventional treatment strategy for all appropriate wounds...
May 24, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28530768/perioperative-management-of-rheumatoid-medications-in-orthopedic-surgery
#10
Kunal Sindhu, Brian Cohen, Joseph A Gil
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disorder known to cause progressive joint destruction. Over time, untreated RA can lead to pain and increasing disability, making orthopedic intervention necessary. The treatment of RA revolves around a variety of medications that blunt the overall immune response. However, this may increase the risk of infection and impair wound healing. Given the nature of this disease, orthopedists frequently encounter patients with RA in the operative setting. To optimize surgical outcomes, orthopedists must carefully manage and pay special attention to the adverse side effects of the complicated medication regimens of these patients perioperatively...
May 20, 2017: Orthopedics
https://www.readbyqxmd.com/read/28513987/dermatological-diseases-in-palliative-care-patients-a-prospective-study-of-271-patients
#11
Lenche Neloska, Katerina Damevska, Andjelka Kuzmanova, Lidija Pavleska, Milenko Kostov, Biljana Petreska Zovic
BACKGROUND: Numerous risk factors place palliative care patients at an increased risk of skin infections, dermatitis, and pressure sores. Furthermore, worsening of chronic skin disorders can be expected, as well as the development of treatment-induced and malignancy-related dermatoses. The objective of the present study was to investigate the prevalence and treatment of dermatological conditions in patients receiving hospital-based palliative care. METHODS: Two hundred seventy-one palliative patients were enrolled...
June 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28504325/therapeutic-ultrasound-for-venous-leg-ulcers
#12
REVIEW
Nicky Cullum, Zhenmi Liu
BACKGROUND: Venous leg ulcers are a type of chronic, recurring, complex wound that is more common in people aged over 65 years. Venous ulcers pose a significant burden to patients and healthcare systems. While compression therapy (such as bandages or stockings) is an effective first-line treatment, ultrasound may have a role to play in healing venous ulcers. OBJECTIVES: To determine whether venous leg ulcers treated with ultrasound heal more quickly than those not treated with ultrasound...
May 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28497520/nitrous-oxide-for-procedural-analgesia-at-home-in-a-child-with-epidermolysis-bullosa
#13
Pablo Ingelmo, Andrew Wei, Gonzalo Rivera
Epidermolysis bullosa comprises a range of conditions characterized by fragile skin with painful blistering induced by minor trauma and friction. The Dowling-Meara variant is a severe form characterized by disseminated painful blistering requiring lifelong skin and wound care. The natural history of the disease is characterized by a chronic course that tends to improve with advancing age. Various multimodal analgesic strategies have been proposed for painful procedures in children with epidermolysis bullosa...
July 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28493644/the-quality-of-life-of-people-who-have-chronic-wounds-and-who-self-treat
#14
Suzanne Kapp, Charne MiIller, Nick Santamaria
AIM: The aim of this study was to investigate the effect of chronic wounds on the physical, emotional, social, lifestyle and financial domains of quality of life among people who self-treat their wounds. BACKGROUND: Patient centered models of care have received increased attention over recent decades because of the potential to contribute positively to the patient's health and well-being. A contemporary understanding of the effect of chronic wounds on quality of life may assist care providers and healthcare systems to respond to patient needs and improve patient outcomes...
May 11, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28485879/evidence-for-silver-in-wound-care-meta-analysis-of-clinical-studies-from-2000-2015
#15
Joachim Dissemond, Johannes Georg Böttrich, Horst Braunwarth, Jörg Hilt, Patricia Wilken, Karl-Christian Münter
BACKGROUND: Given that the scientific evidence for silver in wound care is generally considered insufficient, there is uncertainty among users regarding its clinical use. MATERIAL AND METHODS: A group of experts evaluated the clinical studies on silver in wound management published from 2000-2015. RESULTS: Overall, 851 articles were identified, 173 of which were included and categorized. There were 31 randomized controlled trials (RCTs) and eight cohort studies...
May 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28472912/controlled-delivery-of-bioactive-molecules-for-the-treatment-of-chronic-wounds
#16
J Anjana, V K Rajan, R Biswas, R Jayakumar
A cut or break on the surface of the skin is usually referred to as a wound. Any wound has a potential to heal by itself through a complex cascade of events. However, some wounds show delayed healing due to their underlying physiology and are referred to as chronic wounds like diabetic ulcers, venous ulcers, pressure ulcers and chronic infected ulcers. Extensive care has to be taken for the management of chronic wounds and these have become a major concern in the current medical scenario. The use of bioactive molecules or in other words the molecules that can actively interact with the wound environment and help in wound healing are gaining much importance...
May 3, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28448264/use-of-ovine-based-collagen-extracellular-matrix-and-gentian-violet-methylene-blue-antibacterial-foam-dressings-to-help-improve-clinical-outcomes-in-lower-extremity-wounds-a-retrospective-cohort-study
#17
Eric L Lullove
Dressings that provide broad spectrum metalloprotease reduction along with inherent aspects of an extracellular matrix may contribute to improved wound healing outcomes and shorter treatment times. OBJECTIVE: The author performed a retrospective case series analysis to determine the clinical outcomes of regular debridement with the use of ovine-based collagen extracellular matrix dressings and gentian violet/methylene blue polyurethane antibacterial foam dressings in treating 53 patients with 53 chronic lower extremity wounds (diabetic foot ulcers [DFUs], venous leg ulcers, and heel pressure ulcers)...
April 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28438822/efficacy-and-safety-of-topical-sevoflurane-in-the-treatment-of-chronic-skin-ulcers
#18
F Dámaso Fernández-Ginés, Manuel Cortiñas-Sáenz, Héctor Mateo-Carrasco, Ana Navajas-Gómez de Aranda, Estrella Navarro-Muñoz, Rocío Rodríguez-Carmona, Carmen Fernández-Sánchez, Francisco Sierra-García, José Antonio Morales-Molina
PURPOSE: Results of efficacy and safety assessments of topical sevoflurane use in patients with long-term treatment-refractory vascular ulcers are reported. METHODS: Patients were randomly assigned to receive sevoflurane instillations (1 mL per cm(2) of ulcer area 1-4 times daily) plus standard wound care (ulcer cleaning, debridement, and dressing changes) or standard care only. Topical sevoflurane was initiated during hospitalization, with self- or nurse-administered instillations continued after discharge...
May 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28426572/nonhealing-ulcers-in-patients-with-tophaceous-gout-a-systematic-review
#19
Gretl Lam, Frank L Ross, Ernest S Chiu
GENERAL PURPOSE: To provide information from a review of the literature about chronic ulcers associated with tophaceous gout. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After participating in this educational activity, the participant should be better able to:1. Identify the pathophysiology of tophaceous gout, its presentation, phases, and common comorbidities...
May 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28424334/glycosaminoglycan-based-hydrogels-capture-inflammatory-chemokines-and-rescue-defective-wound-healing-in-mice
#20
Nadine Lohmann, Lucas Schirmer, Passant Atallah, Elke Wandel, Ruben A Ferrer, Carsten Werner, Jan C Simon, Sandra Franz, Uwe Freudenberg
Excessive production of inflammatory chemokines can cause chronic inflammation and thus impair cutaneous wound healing. Capturing chemokine signals using wound dressing materials may offer powerful new treatment modalities for chronic wounds. Here, a modular hydrogel based on end-functionalized star-shaped polyethylene glycol (starPEG) and derivatives of the glycosaminoglycan (GAG) heparin was customized for maximal chemokine sequestration. The material is shown to effectively scavenge the inflammatory chemokines MCP-1 (monocyte chemoattractant protein-1), IL-8 (interleukin-8), and MIP-1α (macrophage inflammatory protein-1α) and MIP-1β (macrophage inflammatory protein-1β) in wound fluids from patients suffering from chronic venous leg ulcers and to reduce the migratory activity of human monocytes and polymorphonuclear neutrophils...
April 19, 2017: Science Translational Medicine
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