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aluminium adjuvant

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https://www.readbyqxmd.com/read/28183282/enhanced-and-long-term-immunogenicity-of-a-her-2-neu-multi-epitope-vaccine-conjugated-to-the-carrier-crm197-in-conjunction-with-the-adjuvant-montanide
#1
Joshua Tobias, Joanna Jasinska, Karin Baier, Michael Kundi, Nicholas Ede, Christoph Zielinski, Ursula Wiedermann
BACKGROUND: We previously identified three short single peptides (P4, P6 and P7) representing different B-cell epitopes on the extracellular domain of Her-2/neu for a vaccine that was tested in a phase-I clinical trial. Here we describe the improvement of the multi peptide vaccine by fusing the single peptides to a hybrid peptide P467. METHODS: After coupling to either virosomes or to diphtheria toxoid CRM197 (CRM), the hybrid peptide was tested in different concentrations in combination with either Montanide or Aluminium hydroxide (Alum) in preclinical studies...
February 9, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28027810/first-in-human-safety-and-immunogenicity-investigations-of-three-adjuvanted-reduced-dose-inactivated-poliovirus-vaccines-ipv-al-ssi-compared-to-full-dose-ipv-vaccine-ssi-when-given-as-a-booster-vaccination-to-adolescents-with-a-history-of-ipv-vaccination-at
#2
Line M Lindgren, Pernille N Tingskov, Annette H Justesen, Bettina S Nedergaard, Klaus J Olsen, Lars V Andreasen, Ingrid Kromann, Charlotte Sørensen, Jes Dietrich, Birgit Thierry-Carstensen
BACKGROUND: There is a demand of affordable IPV in the World. Statens Serum Institut (SSI) has developed three reduced dose IPV formulations adsorbed to aluminium hydroxide; 1/3 IPV-Al, 1/5 IPV-Al and 1/10 IPV-Al SSI, and now report the results of the first investigations in humans. METHODS: 240 Danish adolescents, aged 10-15years, and childhood vaccinated with IPV were booster vaccinated with 1/3 IPV-Al, 1/5 IPV-Al, 1/10 IPV-Al or IPV Vaccine SSI. The booster effects (GMTRs) of the three IPV-Al SSI were compared to IPV Vaccine SSI, and evaluated for non-inferiority...
January 23, 2017: Vaccine
https://www.readbyqxmd.com/read/27941323/immunogenicity-and-safety-of-pandemic-influenza-h5n1-vaccines-in-healthy-adults-through-meta-analysis
#3
Qi Guo, Ze Liu, Jingxia Gao, Jian Zhou, Wenzhu Hu, Yina Cun, Weidong Li, Guoyang Liao
BACKGROUND: There are sporadic cases and local outbreaks of H5N1 avian influenza virus worldwide every year. The World Health Organization (WHO) has paid close attention to the avian influenza epidemic trend. Avian influenza vaccines (AIV) are considered to be useful when an epidemic occurs. However, the use of AIV for humans is not yet widespread. METHODS: This study assessed the immunogenicity and safety of pandemic influenza H5N1 vaccines with inactivated whole virus, split virus and subunit virus vaccines for healthy adults...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27913028/active-immunization-with-brucella-abortus-s19-phage-lysate-elicits-serum-igg-that-protects-guinea-pigs-against-virulent-b-%C3%A2-abortus-and-protects-mice-by-passive-immunization
#4
Lata Jain, Mayank Rawat, Saravanan Ramakrishnan, Bablu Kumar
Brucellosis is an economically important zoonosis of worldwide significance. Earlier (Jain et al., 2015) we reported methodology for generation of phage lysate preparations against Brucella abortus S19 using brucellaphage 'ϕLd'. In this study, using a fixed dose (Two mouse PD100) of lysates, the prophylactic efficacies of both plain and alum gel adjuvanted lysates were evaluated in guinea pig by direct virulent challenge and passive mouse protection test (PMPT). Strong humoral and cell mediated immune responses in guinea pigs and protection comparable to S19 vaccine was observed with low dose (1...
January 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/27908630/non-linear-dose-response-of-aluminium-hydroxide-adjuvant-particles-selective-low-dose-neurotoxicity
#5
Guillemette Crépeaux, Housam Eidi, Marie-Odile David, Yasmine Baba-Amer, Eleni Tzavara, Bruno Giros, François-Jérôme Authier, Christopher Exley, Christopher A Shaw, Josette Cadusseau, Romain K Gherardi
Aluminium (Al) oxyhydroxide (Alhydrogel(®)), the main adjuvant licensed for human and animal vaccines, consists of primary nanoparticles that spontaneously agglomerate. Concerns about its safety emerged following recognition of its unexpectedly long-lasting biopersistence within immune cells in some individuals, and reports of chronic fatigue syndrome, cognitive dysfunction, myalgia, dysautonomia and autoimmune/inflammatory features temporally linked to multiple Al-containing vaccine administrations. Mouse experiments have documented its capture and slow transportation by monocyte-lineage cells from the injected muscle to lymphoid organs and eventually the brain...
January 15, 2017: Toxicology
https://www.readbyqxmd.com/read/27845595/cna-loaded-plga-nanoparticles-improve-humoral-response-againsts-aureus-mediated-infections-in-a-mouse-model-subcutaneous-vs-nasal-administration-strategy
#6
Ida Genta, Claudia Colonna, Bice Conti, Paolo Caliceti, Stefano Salmaso, Pietro Speziale, Giampiero Pietrocola, Enrica Chiesa, Tiziana Modena, Rossella Dorati
The aim of this work was the assessment of the "in vivo" immune response of a poly(lactide-co-glycolide)-based nanoparticulate adjuvant for a sub-unit vaccine, namely, a purified recombinant collagen-binding bacterial adhesion fragment (CNA19), against Staphylococcus aureus-mediated infections. "In vivo" immunogenicity studies were performed on mice: immunisation protocols encompassed subcutaneous and intranasal administration of CNA19 formulated as nanoparticles (NPs) and furthermore, CNA19-loaded NPs formulated in a set-up thermosetting chitosan-β-glycerolphosphate (chitosan-β-GP) solution for intranasal route in order to extend antigen exposure to nasal mucosa...
December 2016: Journal of Microencapsulation
https://www.readbyqxmd.com/read/27651089/immune-responses-of-a-meningococcal-a-w-outer-membrane-vesicle-omv-vaccine-with-and-without-aluminium-hydroxide-adjuvant-in-two-different-mouse-strains
#7
Gro Tunheim, Marianne Arnemo, Lisbeth M Naess, Gunnstein Norheim, Luis Garcia, Daniel Cardoso, Aleida Mandiarote, Domingo Gonzalez, Kalpana Sinnadurai, Åse-Karine Fjeldheim, Karin Bolstad, Einar Rosenqvist
Meningococci (Neisseria meningiditis) of serogroups A and W have caused large epidemics of meningitis in sub-Saharan Africa for decades, and affordable and multivalent vaccines, effective in all age groups, are needed. A bivalent serogroup A and W (A + W) meningococcal vaccine candidate consisting of deoxycholate-extracted outer membrane vesicles (OMV) from representative African disease isolates was previously found to be highly immunogenic in outbred mice when formulated with the adjuvant aluminium hydroxide (AH)...
November 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/27551808/vaccine-adjuvants-why-and-how
#8
Dennis Christensen
Novel vaccine strategies include the so-called subunit vaccines, which encompass only the part of the pathogen to which immune recognition results in protection. The high purity of these vaccines make adverse events less likely, but it also makes the vaccines less immunogenic and therefore potentially less effective. Vaccine adjuvants that increase and modulate the immunogenicity of the vaccine are therefore added to solve this problem. Besides aluminum salts, which have been used in vaccines for 90 years, a number of novel vaccine adjuvants have been included in licensed vaccines over the last 30 years...
October 2, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27515230/insight-into-the-cellular-fate-and-toxicity-of-aluminium-adjuvants-used-in-clinically-approved-human-vaccinations
#9
Matthew Mold, Emma Shardlow, Christopher Exley
Aluminium adjuvants remain the most widely used and effective adjuvants in vaccination and immunotherapy. Herein, the particle size distribution (PSD) of aluminium oxyhydroxide and aluminium hydroxyphosphate adjuvants was elucidated in attempt to correlate these properties with the biological responses observed post vaccination. Heightened solubility and potentially the generation of Al(3+) in the lysosomal environment were positively correlated with an increase in cell mortality in vitro, potentially generating a greater inflammatory response at the site of simulated injection...
August 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27506252/transferability-study-of-cho-cell-clustering-assays-for-monitoring-of-pertussis-toxin-activity-in-acellular-pertussis-vaccines
#10
R Isbrucker, A Daas, L Wagner, A Costanzo
Current regulations for acellular pertussis (aP) vaccines require that they are tested for the presence of residual or reversion-derived pertussis toxin (PTx) activity using the mouse histamine sensitisation test (HIST). Although a CHO cell clustering assay can be used by manufacturers to verify if sufficient inactivation of the substance has occurred in-process, this assay cannot be used at present for the final product due to the presence of aluminium adjuvants which interfere with mammalian cell cultures...
2016: Pharmeuropa Bio & Scientific Notes
https://www.readbyqxmd.com/read/27489804/qs-21-enhances-the-early-antibody-response-to-oil-adjuvant-foot-and-mouth-disease-vaccine-in-cattle
#11
Can Çokçalışkan, Tunçer Türkoğlu, Beyhan Sareyyüpoğlu, Ergün Uzunlu, Ayca Babak, Banu B Özbilge, Veli Gülyaz
PURPOSE: One of the most important tools against foot-and-mouth disease, a highly contagious and variable viral disease of cloven-hoofed animals, is vaccination. However, the effectiveness of foot-and-mouth disease vaccines on slowing the spread of the disease is questionable. In contrast, high potency vaccines providing early protection may solve issues with the spread of the disease, escaping mutants, and persistency. To increase the potency of the vaccine, additives such as saponin and aluminium hydroxide are used...
July 2016: Clinical and Experimental Vaccine Research
https://www.readbyqxmd.com/read/27477507/characterization-of-the-immune-response-and-evaluation-of-the-protective-capacity-of-rssna-against-streptococcus-suis-infection-in-pigs
#12
Lidia Gómez-Gascón, Fernando Cardoso-Toset, Carmen Tarradas, Jaime Gómez-Laguna, Alfonso Maldonado, Jens Nielsen, Alfonso Olaya-Abril, Manuel J Rodríguez-Ortega, Inmaculada Luque
The efforts made to develop vaccines against Streptococcus suis have failed because of lack of common antigens cross-reactive against different serotypes of this species. The cell wall-anchored proteins can be good vaccine candidates due to their high expression and accessibility to antibodies, among these, a cell-wall protein, DNA-nuclease (SsnA), present in most of the S. suis serotypes and clinical isolates collected from infected pigs, was selected. An experimental challenge against S. suis serotype 2 in a pig model was used to validate the efficacy of recombinant SsnA combined with aluminium hydroxide plus Quil A as adjuvants, previously tested in mice by our research group with good results...
August 2016: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/27373900/efficacy-safety-and-immunogenicity-of-the-human-papillomavirus-16-18-as04-adjuvanted-vaccine-in-women-older-than-25-years-7-year-follow-up-of-the-phase-3-double-blind-randomised-controlled-viviane-study
#13
Cosette M Wheeler, S Rachel Skinner, M Rowena Del Rosario-Raymundo, Suzanne M Garland, Archana Chatterjee, Eduardo Lazcano-Ponce, Jorge Salmerón, Shelly McNeil, Jack T Stapleton, Céline Bouchard, Mark G Martens, Deborah M Money, Swee Chong Quek, Barbara Romanowski, Carlos S Vallejos, Bram Ter Harmsel, Vera Prilepskaya, Kah Leng Fong, Henry Kitchener, Galina Minkina, Yong Kuei Timothy Lim, Tanya Stoney, Nahida Chakhtoura, Margaret E Cruickshank, Alevtina Savicheva, Daniel Pereira da Silva, Murdo Ferguson, Anco C Molijn, Wim G V Quint, Karin Hardt, Dominique Descamps, Pemmaraju V Suryakiran, Naveen Karkada, Brecht Geeraerts, Gary Dubin, Frank Struyf
BACKGROUND: Although the risk of human papillomavirus (HPV) infection is greatest in young women, women older than 25 years remain at risk. We present data from the VIVIANE study of the HPV 16/18 AS04-adjuvanted vaccine in adult women after 7 years of follow-up. METHODS: In this phase 3, double-blind, randomised controlled trial, healthy women older than 25 years were enrolled (age stratified: 26-35 years, 36-45 years, and ≥46 years). Up to 15% in each age stratum had a history of HPV infection or disease...
October 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27318565/vaccine-induced-modulation-of-gene-expression-in-turbot-peritoneal-cells-a-microarray-approach
#14
Francisco Fontenla, Verónica Blanco-Abad, Belén G Pardo, Iria Folgueira, Manuel Noia, Antonio Gómez-Tato, Paulino Martínez, José M Leiro, Jesús Lamas
We used a microarray approach to examine changes in gene expression in turbot peritoneal cells after injection of the fish with vaccines containing the ciliate parasite Philasterides dicentrarchi as antigen and one of the following adjuvants: chitosan-PVMMA microspheres, Freund́s complete adjuvant, aluminium hydroxide gel or Matrix-Q (Isconova, Sweden). We identified 374 genes that were differentially expressed in all groups of fish. Forty-two genes related to tight junctions and focal adhesions and/or actin cytoskeleton were differentially expressed in free peritoneal cells...
July 2016: Molecular Immunology
https://www.readbyqxmd.com/read/27296693/safety-tolerability-and-immunogenicity-of-a-recombinant-toxic-shock-syndrome-toxin-rtsst-1-variant-vaccine-a-randomised-double-blind-adjuvant-controlled-dose-escalation-first-in-man-trial
#15
Michael Schwameis, Bernhard Roppenser, Christa Firbas, Corina S Gruener, Nina Model, Norbert Stich, Andreas Roetzer, Nina Buchtele, Bernd Jilma, Martha M Eibl
BACKGROUND: Staphylococcal toxic shock syndrome is a superantigen-driven potentially life-threatening disease affecting mainly young and otherwise healthy individuals. Currently, no specific treatment or preventive measure is available. We aimed to assess the safety, tolerability, and immunogenicity of a recombinant detoxified toxic shock syndrome toxin-1 variant (rTSST-1v) vaccine in adult volunteers. METHODS: In this randomised, double-blind, adjuvant-controlled, dose-escalation first-in-human trial, healthy adults aged 18-64 years were enrolled from the Medical University of Vienna, Austria...
September 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27139805/safety-and-immunogenicity-of-an-investigational-maternal-trivalent-group-b-streptococcus-vaccine-in-healthy-women-and-their-infants-a-randomised-phase-1b-2-trial
#16
Shabir A Madhi, Clare L Cutland, Lisa Jose, Anthonet Koen, Niresha Govender, Frederick Wittke, Morounfolu Olugbosi, Ajoke Sobanjo-Ter Meulen, Sherryl Baker, Peter M Dull, Vas Narasimhan, Karen Slobod
BACKGROUND: Maternal group B streptococcus (GBS) serotype-specific capsular antibody concentrations are correlated with susceptibility to neonatal GBS invasive disease. Maternal immunisation against GBS during pregnancy might protect infants across the period of susceptibility to invasive disease, but no licensed vaccine exists. This study assessed the safety and immunogenicity of a CRM197-conjugated trivalent GBS vaccine in non-pregnant and pregnant women, and antibody transfer to their infants...
August 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27139352/aluminium-adjuvanted-vaccines-a-review-of-the-current-state-of-knowledge
#17
REVIEW
Aleksandra Gołoś, Anna Lutyńska
Since decades aluminium formulations such as aluminium hydroxide and aluminium phosphate are widely used as adjuvants in vaccines for human use. They increase immune response induced by the vaccine antigens by mechanisms eg. a depot effect at the injection site, activation of the complement and stimulation of the macrophages. Many studies, both case control ones and those performed in vivo on animal models, confirmed the safety of aluminium adjuvants even in vaccinated infants and children. Although some of the aluminium-adjuvanted vaccines have certain limitations such as no Th1 reactivity and low stability at temperatures below 2ºC, its easy use, safety profile and low manufacturing costs confirm its suitability...
2015: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/27012396/selective-estrogen-receptor-modulators-differentially-alter-the-immune-response-of-gilthead-seabream-juveniles
#18
M C Rodenas, I Cabas, A García-Alcázar, J Meseguer, V Mulero, A García-Ayala
17α-ethynylestradiol (EE2), a synthetic estrogen used in oral contraceptives and hormone replacement therapy, tamoxifen (Tmx), a selective estrogen-receptor modulator used in hormone replacement therapy, and G1, a G protein-coupled estrogen receptor (GPER) selective agonist, differentially increased the hepatic vitellogenin (vtg) gene expression and altered the immune response in adult gilthead seabream (Sparus aurata L.) males. However, no information exists on the effects of these compounds on the immune response of juveniles...
May 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27010263/antibody-response-to-epsilon-toxin-of-clostridium-perfringens-in-captive-red-deer-cervus-elaphus-over-a-13-month-period
#19
Christopher Scala, Nicolas Duffard, Guy Beauchamp, Séverine Boullier, Yann Locatelli
Deer are sensitive to clostridial diseases, and vaccination with clostridial toxoids is the method of choice to prevent these infections in ruminants. The purpose of this study was to evaluate the serologic responses in red deer (Cervus elaphus) over a 13-mo period after vaccination with a multivalent clostridial vaccine, containing an aluminium hydroxide adjuvant. Antibody production to the Clostridium perfringens type D epsilon toxin component of the vaccine was measured using an indirect enzyme-linked immunosorbent assay...
March 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/26997127/aluminium-and-the-human-breast
#20
REVIEW
P D Darbre
The human population is exposed to aluminium (Al) from diet, antacids and vaccine adjuvants, but frequent application of Al-based salts to the underarm as antiperspirant adds a high additional exposure directly to the local area of the human breast. Coincidentally the upper outer quadrant of the breast is where there is also a disproportionately high incidence of breast cysts and breast cancer. Al has been measured in human breast tissues/fluids at higher levels than in blood, and experimental evidence suggests that at physiologically relevant concentrations, Al can adversely impact on human breast epithelial cell biology...
June 2016: Morphologie: Bulletin de L'Association des Anatomistes
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