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Intracranial volume measurement

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https://www.readbyqxmd.com/read/29772365/location-of-thalamic-hemorrhage-impacts-prognosis
#1
Brandon L Neisewander, Kimberly Hu, Zach Tan, Jack Zakrzewski, Pouyan Kheirkhah, Prateek Kumar, Miloni Shah, Douglas Cotanche, Kalpesh Shah, Darian R Esfahani, Ankit I Mehta
OBJECT: Approximately 12% of intracerebral hemorrhages (ICH) occur in the thalamus. Understanding the anatomical regions involved with thalamic hemorrhages is potentially useful, offering the physician a more accurate prognosis for patient outcomes. This study was performed to determine if thalamic hemorrhage location observed on a computed tomography scan (CT) is predictive of neurologic outcomes. METHODS: A sample of 168 thalamic hemorrhage patients admitted to a tertiary care center was analyzed...
May 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29771828/results-following-adoption-of-a-modified-melbourne-technique-of-total-scaphocephaly-correction
#2
Julia D Sharma, Justine L O'Hara, Alessandro Borghi, Naiara Florez-Rodriguez, William Breakey, Juling Ong, Nu Owase Jeelani, David J Dunaway, Greg James
The Melbourne technique was described in 2008 as a novel method for complete correction of scaphocephaly. Since 2015, it has become our operation of choice for children with sagittal synostosis who are too old at presentation for minimally invasive techniques. Our modifications were 2-position (initially supine then prone) technique and undertaking a formal fronto-orbital remodeling to correct forehead contour. Retrospective chart review was used to record demographics, blood transfusion frequency and volumes, operating time, length of stay, clinical outcome, and complications...
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29745531/-hippocampal-subfield-volume-alteration-in-post-traumatic-stress-disorder-a-magnetic-resonance-imaging-study
#3
Lu Lu, Lianqing Zhang, Xinyu Hu, Xiaoxiao Hu, Lingjiang Li, Qiyong Gong, Xiaoqi Huang
In the current study, we aim to investigate whether post-traumatic stress disorder (PTSD) is associated with structural alterations in specific subfields of hippocampus comparing with trauma-exposed control (TC) in a relatively large sample. We included 67 PTSD patients who were diagnosed under Diagnostic and Statistical Manual of Mental Disorders (4th Edition) (DSM-Ⅳ) criteria and 78 age- and sex-matched non-PTSD adult survivors who experienced similar stressors. High resolution T1 weighted images were obtained via a GE 3...
April 1, 2018: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29734209/continuous-low-dose-infusion-of-patupilone-increases-the-therapeutic-index-in-mouse-and-rat-tumour-models
#4
Mike Becquet, Laurent Laborde, Celine Texier, Dario Sterker, Hans-Peter Gschwind, Ulrike Pfaar, Markus Wartmann, Terry M O'Reilly, Paul M McSheehy
Patupilone is a microtubule-targeted cytotoxic agent with clinical efficacy, but causes diarrhoea in more than 80% of patients. The efficacy and tolerability of patupilone delivered continuously by subcutaneous (s.c.) mini-pumps [(mini-pump dose (MPD)] or by intravenous bolus administration [intravenous bolus dose (IVBD)] were compared preclinically to determine whether the therapeutic index could be improved. The antiproliferative potency in vitro of patupilone was determined by measuring total cell protein...
May 4, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29724240/mesenchymal-stem-cells-attenuate-blood-brain-barrier-leakage-after-cerebral-ischemia-in-mice
#5
Zhuo Cheng, Liping Wang, Meijie Qu, Huaibin Liang, Wanlu Li, Yongfang Li, Lidong Deng, Zhijun Zhang, Guo-Yuan Yang
BACKGROUND: Ischemic stroke induced matrixmetallo-proteinase-9 (MMP-9) upregulation, which increased blood-brain barrier permeability. Studies demonstrated that mesenchymal stem cell therapy protected blood-brain barrier disruption from several cerebrovascular diseases. However, the underlying mechanism was largely unknown. We therefore hypothesized that mesenchymal stem cells reduced blood-brain barrier destruction by inhibiting matrixmetallo-proteinase-9 and it was related to intercellular adhesion molecule-1 (ICAM-1)...
May 3, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29710057/efficacy-of-dural-sealant-system-for-preventing-brain-shift-and-improving-accuracy-in-deep-brain-stimulation-surgery
#6
Tatsuya Sasaki, Takashi Agari, Ken Kuwahara, Ittetsu Kin, Mihoko Okazaki, Susumu Sasada, Aiko Shinko, Masahiro Kameda, Takao Yasuhara, Isao Date
The success of deep brain stimulation (DBS) depends heavily on surgical accuracy, and brain shift is recognized as a significant factor influencing accuracy. We investigated the factors associated with surgical accuracy and showed the effectiveness of a dural sealant system for preventing brain shift in 32 consecutive cases receiving DBS. Thirty-two patients receiving DBS between March 2014 and May 2015 were included in this study. We employed conventional burr hole techniques for the first 18 cases (Group I) and a dural sealant system (DuraSeal) for the subsequent 14 cases (Group II)...
May 1, 2018: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29696505/intracranial-pressure-monitoring-in-diffuse-brain-injury-why-the-developing-world-needs-it-more
#7
Tarang K Vora, Sudish Karunakaran, Ajay Kumar, Anil Chiluka, Harish Srinivasan, Kanishk Parmar, Srivatsan Thirumalai Vasu, Rahul Srinivasan, H A Chandan, P S Vishnu, Lakshay Raheja
BACKGROUND: Use of ICP monitoring is considered to be part of "standard of care" in management of severe traumatic brain injury, but it is rarely used in developing countries. The authors present a study which evaluates the efficacy and outcomes of ICP monitoring at a high-volume trauma center in India. METHODS: Data on management and outcomes for 126 patients who were admitted with diffuse traumatic brain injury (GCS 3-8) were studied prospectively over an 18-month period...
April 26, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29675990/intracranial-administration-of-the-g-protein-coupled-estrogen-receptor-1-antagonist-g-15-selectively-affects-dimorphic-characteristics-of-the-song-system-in-zebra-finches-taeniopygia-guttata
#8
Mahtab Attarhaie Tehrani, Sean L Veney
In zebra finches (Taeniopygia guttata), estradiol contributes to sexual differentiation of the song system but the receptor(s) underlying its action are not exactly known. Whereas mRNA and/or protein for nuclear estrogen receptors ERα and ERβ are minimally expressed, G-protein coupled estrogen receptor 1 (GPER1) has a much greater distribution within neural song regions and the syrinx. At present, however, it is unclear if this receptor contributes to dimorphic development of the song system. To test this, the specific GPER1 antagonist, G-15, was intracranially administered to zebra finches for 25 days beginning on the day of hatching...
April 20, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29674417/value-of-quantitative-collateral-scoring-on-ct-angiography-in-patients-with-acute-ischemic-stroke
#9
A M M Boers, R Sales Barros, I G H Jansen, O A Berkhemer, L F M Beenen, B K Menon, D W J Dippel, A van der Lugt, W H van Zwam, Y B W E M Roos, R J van Oostenbrugge, C H Slump, C B L M Majoie, H A Marquering
BACKGROUND AND PURPOSE: Many studies have emphasized the relevance of collateral flow in patients presenting with acute ischemic stroke. Our aim was to evaluate the relationship of the quantitative collateral score on baseline CTA with the outcome of patients with acute ischemic stroke and test whether the timing of the CTA acquisition influences this relationship. MATERIALS AND METHODS: From the Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands (MR CLEAN) data base, all baseline thin-slice CTA images of patients with acute ischemic stroke with intracranial large-vessel occlusion were retrospectively collected...
April 19, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29672584/fast-csf-mri-for-brain-segmentation-cross-validation-by-comparison-with-3d-t1-based-brain-segmentation-methods
#10
Lisa A van der Kleij, Jeroen de Bresser, Jeroen Hendrikse, Jeroen C W Siero, Esben T Petersen, Jill B De Vis
OBJECTIVE: In previous work we have developed a fast sequence that focusses on cerebrospinal fluid (CSF) based on the long T2 of CSF. By processing the data obtained with this CSF MRI sequence, brain parenchymal volume (BPV) and intracranial volume (ICV) can be automatically obtained. The aim of this study was to assess the precision of the BPV and ICV measurements of the CSF MRI sequence and to validate the CSF MRI sequence by comparison with 3D T1-based brain segmentation methods. MATERIALS AND METHODS: Ten healthy volunteers (2 females; median age 28 years) were scanned (3T MRI) twice with repositioning in between...
2018: PloS One
https://www.readbyqxmd.com/read/29664991/haemostatic-therapies-for-acute-spontaneous-intracerebral-haemorrhage
#11
REVIEW
Rustam Al-Shahi Salman, Zhe Kang Law, Philip M Bath, Thorsten Steiner, Nikola Sprigg
BACKGROUND: Outcome after spontaneous (non-traumatic) intracerebral haemorrhage (ICH) is influenced by haematoma volume; up to one-third of ICHs enlarge within 24 hours of onset. Early haemostatic therapy might improve outcome by limiting haematoma growth. This is an update of a Cochrane Review first published in 2006, and last updated in 2009. OBJECTIVES: To examine 1) the effectiveness and safety of individual classes of haemostatic therapies, compared against placebo or open control, in adults with acute spontaneous intracerebral haemorrhage, and 2) the effects of each class of haemostatic therapy according to the type of antithrombotic drug taken immediately before ICH onset (i...
April 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29652232/long-term-tumor-control-following-stereotactic-radiosurgery-for-jugular-paraganglioma-using-3d-volumetric-segmentation
#12
Neil S Patel, Matthew L Carlson, Bruce E Pollock, Colin L W Driscoll, Brian A Neff, Robert L Foote, Christine M Lohse, Michael J Link
OBJECTIVE The morbidity of gross-total resection of jugular paraganglioma (JP) is often unacceptable due to the potential for irreversible lower cranial neuropathy. Stereotactic radiosurgery (SRS) has been used at the authors' institution since 1990 for the treatment of JP and other benign intracranial tumors. Conventional means of assessing tumor progression using linear measurements or elliptical approximations are imprecise due to the irregular shape and insinuating growth pattern of JP. The objective of this study was to assess long-term tumor control in these patients by using slice-by-slice 3D volumetric segmentation of serial MRI data...
April 13, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29627794/association-of-follow-up-infarct-volume-with-functional-outcome-in-acute-ischemic-stroke-a-pooled-analysis-of-seven-randomized-trials
#13
Anna M M Boers, Ivo G H Jansen, Ludo F M Beenen, Thomas G Devlin, Luis San Roman, Ji Hoe Heo, Marc Ribó, Scott Brown, Mohammed A Almekhlafi, David S Liebeskind, Jeanne Teitelbaum, Hester F Lingsma, Wim H van Zwam, Patricia Cuadras, Richard du Mesnil de Rochemont, Marine Beaumont, Martin M Brown, Albert J Yoo, Robert J van Oostenbrugge, Bijoy K Menon, Geoffrey A Donnan, Jean Louis Mas, Yvo B W E M Roos, Catherine Oppenheim, Aad van der Lugt, Richard J Dowling, Michael D Hill, Antoni Davalos, Thierry Moulin, Nelly Agrinier, Andrew M Demchuk, Demetrius K Lopes, Lucia Aja Rodríguez, Diederik W J Dippel, Bruce C V Campbell, Peter J Mitchell, Fahad S Al-Ajlan, Tudor G Jovin, Jeremy Madigan, Gregory W Albers, Sebastien Soize, Francis Guillemin, Vivek K Reddy, Serge Bracard, Jordi Blasco, Keith W Muir, Raul G Nogueira, Phil M White, Mayank Goyal, Stephen M Davis, Henk A Marquering, Charles B L M Majoie
BACKGROUND: Follow-up infarct volume (FIV) has been recommended as an early indicator of treatment efficacy in patients with acute ischemic stroke. Questions remain about the optimal imaging approach for FIV measurement. OBJECTIVE: To examine the association of FIV with 90-day modified Rankin Scale (mRS) score and investigate its dependency on acquisition time and modality. METHODS: Data of seven trials were pooled. FIV was assessed on follow-up (12 hours to 2 weeks) CT or MRI...
April 7, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29596338/non-invasive-electromagnetic-skin-patch-sensor-to-measure-intracranial-fluid-volume-shifts
#14
Jacob Griffith, Kim Cluff, Brandon Eckerman, Jessica Aldrich, Ryan Becker, Peer Moore-Jansen, Jeremy Patterson
Elevated intracranial fluid volume can drive intracranial pressure increases, which can potentially result in numerous neurological complications or death. This study's focus was to develop a passive skin patch sensor for the head that would non-invasively measure cranial fluid volume shifts. The sensor consists of a single baseline component configured into a rectangular planar spiral with a self-resonant frequency response when impinged upon by external radio frequency sweeps. Fluid volume changes (10 mL increments) were detected through cranial bone using the sensor on a dry human skull model...
March 29, 2018: Sensors
https://www.readbyqxmd.com/read/29593880/atrophy-of-the-putamen-at-time-of-clinical-motor-onset-in-huntington-s-disease-a-6-year-follow-up-study
#15
Emma M Coppen, Jeroen van der Grond, Raymund A C Roos
Background: Striatal atrophy is detectable many years before the predicted onset of motor symptoms in premanifest Huntington's disease (HD). However, the extent of these neurodegenerative changes at the actual time of conversion from premanifest to a motor manifest disease stage is not known. With this study, we aimed to assess differences in degree and rate of atrophy between converters, i.e. premanifest individuals who develop clinically manifest HD over the course of the study, and non-converters...
2018: Journal of Clinical Movement Disorders
https://www.readbyqxmd.com/read/29575385/transcranial-sonography-to-differentiate-primary-intracerebral-hemorrhage-from-cerebral-infarction-with-hemorrhagic-transformation
#16
Wolf-Dirk Niesen, Axel Schläger, Matthias Reinhard, Hannah Fuhrer
BACKGROUND AND PURPOSE: The differentiation of primary intracerebral hemorrhage (ICH) from parenchymal hemorrhagic transformation within an ischemic infarction (PHI) is crucial in order to adapt therapeutic measures. We hypothesized that a distinction of ICH and PHI can be made at bedside via transcranial gray-scale and perfusion sonography. METHODS: We prospectively included 14 patients with intracranial hemorrhage on admission imaging in this pilot study. Differentiation between ICH and PHI was made either by cerebral magnetic resonance imaging or follow-up computed tomography scan...
March 25, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29572283/cerebellar-volume-as-an-imaging-marker-of-development-in-infants-with-tuberous-sclerosis-complex
#17
Siddharth Srivastava, Anna K Prohl, Benoit Scherrer, Kush Kapur, Darcy A Krueger, Simon K Warfield, Mustafa Sahin
OBJECTIVE: In this cohort analysis, we studied 1-year-old infants with tuberous sclerosis complex (TSC), correlating volumes of cerebellar structures with neurodevelopmental measures. METHODS: We analyzed data from a prospective biomarker study in infants with TSC (ClinicalTrials.gov NCT01780441). We included participants aged 12 months with an identified mutation of TSC1 or TSC2 . Using MRI segmentation performed with the PSTAPLE algorithm, we measured relative volumes (structure volume divided by intracranial contents volume) of the following structures: right/left cerebellar white matter, right/left cerebellar exterior, vermal lobules I-V, vermal lobules VI-VII, and vermal lobules VIII-X...
March 23, 2018: Neurology
https://www.readbyqxmd.com/read/29554002/cerebrospinal-fluid-pressure-reduction-results-in-dynamic-changes-in-optic-nerve-angle-on-magnetic-resonance-imaging
#18
Ranliang Hu, John Holbrook, Nancy J Newman, Valerie Biousse, Beau B Bruce, Deqiang Qiu, John Oshinski, Amit M Saindane
BACKGROUND: Optic nerve sheath tortuosity is a previously reported, but incompletely characterized, finding in idiopathic intracranial hypertension (IIH). We hypothesized that optic nerve angle (ONA), as a quantitative measure of tortuosity, would change dynamically with cerebrospinal fluid (CSF) pressure status of patients with IIH immediately before and after lumbar puncture (LP). METHODS: Consecutive patients with suspected IIH referred for MRI and diagnostic LP were prospectively enrolled in this single institution, institutional review board-approved study...
March 16, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29552780/patient-specific-quality-assurance-for-intracranial-cases-in-robotic-radiosurgery-system
#19
Canan Koksal, Ugur Akbas, Nazmiye Donmez Kesen, Murat Okutan, Hatice Bilge, Gonul Kemikler
PURPOSE: The purpose of this study was to perform pretreatment patient-specific quality assurance (QA) for intracranial irradiation using CyberKnife with an ion chamber. METHODS: Twenty-five intracranial plans created using the ray-tracing algorithm were used for this study. Computed tomography (CT) images of the water-equivalent RW3 slab phantom with PinPoint ionization chamber were acquired with 1-mm slice thickness and transferred to the MultiPlan treatment planning system (TPS)...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29550646/metabolic-profiling-of-intra-and-extracranial-carotid-artery-atherosclerosis
#20
Dina Vojinovic, Sven J van der Lee, Cornelia M van Duijn, Meike W Vernooij, Maryam Kavousi, Najaf Amin, Ayşe Demirkan, M Arfan Ikram, Aad van der Lugt, Daniel Bos
BACKGROUND AND AIMS: Increasing evidence shows that intracranial carotid artery atherosclerosis may develop under the influence of a differential metabolic risk factor profile than atherosclerosis in the extracranial part of the carotid artery. To further elucidate these differences, we investigated associations of a wide range of circulating metabolites with intracranial and extracranial carotid artery atherosclerosis. METHODS: From the population-based Rotterdam Study, blood samples from 1111 participants were used to determine a wide range of metabolites by proton nuclear magnetic resonance (NMR)...
March 8, 2018: Atherosclerosis
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