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https://www.readbyqxmd.com/read/30188033/-what-s-new-in-the-treatment-of-suppurative-hidradenitis-in-2018
#1
G Giet, E Lebas, F Libon, B Dezfoulian, A F Nikkels
Hidradenitis suppurativa (HS), also known as Verneuil's disease and acne inversa, is a chronic inflammatory skin disease characterized by a dysfunction of the pilosebaceous structures resulting in occlusion and inflammation. The disease usually starts after puberty, on average between twenty and thirty years, with subcutaneous painful inflammatory nodules, abscess collections, fistulization and scars mainly in the axillary, inguinal, sub-mammary, perineal and perianal regions. It is a multifactorial disease with the most commonly cited risk factors or aggravating factors being smoking, obesity, and HS family history...
September 2018: Revue Médicale de Liège
https://www.readbyqxmd.com/read/30168900/dissecting-folliculitis-dissecting-cellulitis-of-the-scalp-a-66-patient-case-series-and-proposal-of-classification
#2
Chaw-Ning Lee, WenChieh Chen, Chao-Kai Hsu, Tzu-Teng Weng, Julia Yu-Yun Lee, Chao-Chun Yang
BACKGROUND AND OBJECTIVES: Dissecting folliculitis (DF) or dissecting cellulitis of the scalp is regarded as a rare disease with disfiguring scarring alopecia. This study aimed to analyze the features of DF and to propose a classification to define its severity. PATIENTS AND METHODS: A hospital-based retrospective study was conducted. Patients with a histopathological diagnosis or clinical features leading to diagnosis of DF were included and classified into three stages...
August 31, 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/30078878/factors-aggravating-or-precipitating-acne-in-indian-adults-a-hospital-based-study-of-110-cases
#3
Rani Maria George, Rajiv Sridharan
Background: Although acne is principally a disorder of adolescence, the number of adult patients with acne is increasing. Adult acne is defined as the presence of acne beyond the age of 25 years. There is relatively few data on the prevalence and studies of acne in adult population. Aim and Objectives: To analyze the various factors that aggravate or precipitate acne vulgaris in Indian adults. Materials and methods: The study was done at the Department of Dermatology at a tertiary care center in Kerala for a period of 1 year...
July 2018: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/29600573/the-association-between-helicobacter-pylori-infection-and-the-risk-of-advanced-colorectal-neoplasia-may-differ-according-to-age-and-cigarette-smoking
#4
Hyunsung Park, Jae Jun Park, Yoo Mi Park, Su Jung Baik, Hyun Ju Lee, Da Hyun Jung, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park
BACKGROUND: The association between Helicobacter pylori infection and advanced colorectal neoplasia (ACN) remains controversial. This study aimed to clarify the association between H. pylori infection and ACN according to age groups. METHODS: We retrospectively analyzed the association between H. pylori infection and ACN in patients aged <50 and ≥50 years receiving a health checkup that included colonoscopy. Helicobacter pylori positivity was determined by the results of serum anti-H...
June 2018: Helicobacter
https://www.readbyqxmd.com/read/29573406/t-helper-17-cell-regulatory-t-cell-imbalance-in-hidradenitis-suppurativa-acne-inversa-the-link-to-hair-follicle-dissection-obesity-smoking-and-autoimmune-comorbidities
#5
REVIEW
B C Melnik, S M John, W Chen, G Plewig
BACKGROUND: Disintegration of the infundibula of terminal hair follicles (HFs) in intertriginous skin areas exhibits the histological hallmark of hidradenitis suppurativa (HS)/acne inversa, featuring a dissecting terminal hair folliculitis. Elevated serum levels of interleukin (IL)-17 and local increase in the ratio of proinflammatory T helper (Th)17 cells and anti-inflammatory regulatory T cells (Tregs) have been reported. Perifollicular Tregs play a key role in HF stem cell homeostasis and infundibular integrity...
August 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29410726/adult-acne-versus-adolescent-acne-a-retrospective-study-of-1-167-patients
#6
Nevena Skroza, Ersilia Tolino, Alessandra Mambrin, Sara Zuber, Veronica Balduzzi, Anna Marchesiello, Nicoletta Bernardini, Ilaria Proietti, Concetta Potenza
Background: Acne is predominantly known as a skin disorder of the adolescent population. However, current research indicates that the prevalence of adult patients with acne, especially among women, is increasing. Objective: The objective of this study was to evaluate differences between adults and teenagers with regard to acne prevalence, patient sex, acne severity, and quality of life. In adult patients, we considered differences in family history of acne, onset, and smoking habits. Design: We performed a retrospective study of a total of 1,167 patients with acne who attended our outpatient clinic from January 2008 to March 2015...
January 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29380349/acne-and-hidradenitis-suppurativa
#7
REVIEW
A Pink, F Anzengruber, A A Navarini
Acne and hidradenitis suppurativa (HS) both centre on hair follicles. They often occur together as part of the acne tetrad, but are found in distinct localizations. Acne is primarily defined by the presence of comedones and inflammatory lesions. However, in HS the intertriginous localization and chronicity play equally important roles for the diagnosis to the inflammatory lesions. Genetics, bacteria, environmental factors and innate inflammation have all been found to play a role in acne and/or HS. Surprisingly, there is little overlap between the findings so far...
March 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29359244/a-scoring-model-for-predicting-advanced-colorectal-neoplasia-in-a-screened-population-of-asymptomatic-japanese-individuals
#8
Masau Sekiguchi, Yasuo Kakugawa, Minori Matsumoto, Takahisa Matsuda
BACKGROUND: Risk stratification of screened populations could help improve colorectal cancer (CRC) screening. Use of the modified Asia-Pacific Colorectal Screening (APCS) score has been proposed in the Asia-Pacific region. This study was performed to build a new useful scoring model for CRC screening. METHODS: Data were reviewed from 5218 asymptomatic Japanese individuals who underwent their first screening colonoscopy. Multivariate logistic regression was used to investigate risk factors for advanced colorectal neoplasia (ACN), and a new scoring model for the prediction of ACN was developed based on the results...
January 22, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29194788/a-cross-sectional-study-of-clinical-factors-associated-with-acne-facial-scarring-in-patients-with-active-acne
#9
LETTER
C Dessinioti, C Zisimou, E Platsidaki, A Katsambas, C Antoniou
No abstract text is available yet for this article.
June 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29169877/cetuximab-plus-carboplatin-and-paclitaxel-with-or-without-bevacizumab-versus-carboplatin-and-paclitaxel-with-or-without-bevacizumab-in-advanced-nsclc-swog-s0819-a-randomised-phase-3-study
#10
Roy S Herbst, Mary W Redman, Edward S Kim, Thomas J Semrad, Lyudmila Bazhenova, Gregory Masters, Kurt Oettel, Perry Guaglianone, Christopher Reynolds, Anand Karnad, Susanne M Arnold, Marileila Varella-Garcia, James Moon, Philip C Mack, Charles D Blanke, Fred R Hirsch, Karen Kelly, David R Gandara
BACKGROUND: EGFR antibodies have shown promise in patients with advanced non-small-cell lung cancer (NSCLC), particularly with squamous cell histology. We hypothesised that EGFR copy number by fluorescence in-situ hybridisation (FISH) can identify patients most likely to benefit from these drugs combined with chemotherapy and we aimed to explore the activity of cetuximab with chemotherapy in patients with advanced NSCLC who are EGFR FISH-positive. METHODS: We did this open-label, phase 3 study (SWOG S0819) at 277 sites in the USA and Mexico...
January 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29123122/identification-of-low-oxygen-tolerating-bacteria-in-prostate-secretions-of-cancer-patients-and-discussion-of-possible-aetiological-significance
#11
Roshni Bhudia, Amar Ahmad, Onyinye Akpenyi, Angela Whiley, Mark Wilks, Tim Oliver
The microaerophylic organism Propionibacterium acnes has shown consistent association with prostate cancer (PC). Studies linking circumcision with reduced PC further support anaerobes involvement as circumcision reduces anaerobe colonisation on the glans penis. A 1988 study linked anaerobes with PC but considered them as opportunists in necrotic tumour. A hypothesis that a "Helicobacter-like" process causes PC justified this pilot study. Active surveillance patients were enrolled. Post-prostate massage urine samples were screened using the Matrix-Assisted Laser Desorption/Ionization Time-of-Flight (MALDI-TOF) technique for bacterial identification after culture in anaerobic and aerobic conditions...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29056081/the-risks-and-benefits-of-cannabis-in-the-dermatology-clinic
#12
REVIEW
Gurbir Dhadwal, Mark G Kirchhof
Cannabis ( Cannabis sativa/indica), also known as marijuana, has been used for medicinal and recreational purposes for millennia. There has been a recent trend to legalize the use of cannabis, as illustrated by the recent legalization votes in numerous states in the United States and legislation in Canada to allow recreational cannabis use. With this increasing consumption of cannabis, dermatologists will see increased pressure to prescribe cannabis and will see the side effects of cannabis use with greater frequency...
March 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28707712/acne-prevalence-and-associations-with-lifestyle-a-cross-sectional-online-survey-of-adolescents-young-adults-in-7-european-countries
#13
P Wolkenstein, A Machovcová, J C Szepietowski, D Tennstedt, S Veraldi, A Delarue
BACKGROUND: Although acne vulgaris is a common skin disorder, limited epidemiological data exist specifically for European populations. OBJECTIVE: To determine the prevalence of self-reported acne among young people in Europe and evaluate the effect of lifestyle on acne. METHODS: We conducted a cross-sectional population-based online survey in representative samples of individuals aged 15-24 years in Belgium, Czech and Slovak Republics, France, Italy, Poland and Spain (n = 10 521), identified by a quota sampling method based on age, geographic location and socio-professional category...
February 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28609760/epidemiology-of-acne-vulgaris-in-18-year-old-male-army-conscripts-in-a-south-brazilian-city
#14
Rodrigo Pereira Duquia, Iná da Silva Dos Santos, Hiram de Almeida, Paulo Ricardo Martins Souza, Juliano de Avelar Breunig, Christos C Zouboulis
BACKGROUND: Prevalence of acne varies worldwide. Several factors (age, skin color, body fat, diet, and smoking) have been investigated as risk factors. OBJECTIVE: A total of 2,201 18-year-old males living in Pelotas, South Brazil, were evaluated in order to examine the prevalence of acne and associated factors. METHODS: A cross-sectional population-based study was conducted. A dermatologist performed the clinical examination of the face and trunk for identification of acne lesions...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28256718/lipocalin-2-is-expressed-by-activated-granulocytes-and-keratinocytes-in-affected-skin-and-reflects-disease-activity-in-acne-inversa-hidradenitis-suppurativa
#15
K Wolk, J Wenzel, A Tsaousi, E Witte-Händel, N Babel, C Zelenak, H-D Volk, W Sterry, S Schneider-Burrus, R Sabat
BACKGROUND: Acne inversa (AI)/hidradenitis suppurativa is a chronic inflammatory disease characterized by painful axillary, inguinal and perianal skin lesions with deep-seated nodules, abscesses and fistulae. OBJECTIVES: This study aimed to identify and characterize the key players in AI pathogenesis. METHODS: Epidemiological and anamnestic data for patients with AI were collected, and blood and skin samples were also taken. Healthy participants and patients with psoriasis served as controls...
November 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28225954/frequency-severity-and-related-factors-of-androgenetic-alopecia-in-dermatology-outpatient-clinic-hospital-based-cross-sectional-study-in-turkey
#16
Kubra Esen Salman, Ilknur Kivanc Altunay, Nihal Asli Kucukunal, Asli Aksu Cerman
BACKGROUND: Androgenetic alopecia (AGA) is a patterned hair loss occurring due to systemic androgen and genetic factors. It is the most common cause of hair loss in both genders. In recent years, many studies investigating the relation between systemic diseases and androgenetic alopecia presented controversial results. OBJECTIVES: In this study we aimed to investigate the frequency of androgenetic alopecia, the presence of accompanying systemic diseases, the relation between body mass index and androgenetic alopecia severity and the association of hyperandrogenemia signs with androgenetic alopecia in patients who referred to our outpatient clinic...
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28195077/effects-of-air-pollution-on-the-skin-a-review
#17
REVIEW
Poonam Puri, Shashi Kumar Nandar, Sushruta Kathuria, V Ramesh
The increase in air pollution over the years has had major effects on the human skin. Various air pollutants such as ultraviolet radiation, polycyclic aromatic hydrocarbons, volatile organic compounds, oxides, particulate matter, ozone and cigarette smoke affect the skin as it is the outermost barrier. Air pollutants damage the skin by inducing oxidative stress. Although human skin acts as a biological shield against pro-oxidative chemicals and physical air pollutants, prolonged or repetitive exposure to high levels of these pollutants may have profound negative effects on the skin...
July 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28110842/biomarkers-in-patients-admitted-to-the-emergency-department-after-exposure-to-acrylonitrile-in-a-major-railway-incident-involving-bulk-chemical-material
#18
Sebastiaan Colenbie, Walter Buylaert, Christophe Stove, Ellen Deschepper, Koenraad Vandewoude, Tom De Smedt, Michael Bader, Thomas Göen, An Van Nieuwenhuyse, Peter De Paepe
BACKGROUND: A railway incident with victims of exposure to the cyanogenic substance acrylonitrile (ACN). AIMS: We retrospectively (i)built an inventory of the clinical characteristics of individuals admitted to surrounding emergency departments (ED's) and (ii)studied the correlation between N-2-cyanoethylvaline (CEV), a biomarker used in a population study for evaluating exposure to ACN, with lactate and thiocyanate (SCN), biomarkers determined during emergency care...
March 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28060687/adult-acne-prevalence-and-portrayal-in-primary-healthcare-patients-in-the-greater-porto-area-portugal
#19
Diogo Semedo, Filipa Ladeiro, Mariana Ruivo, Carlos D'Oliveira, Filipa De Sousa, Mariana Gayo, Clara Lima, Frederico Magalhães, Rui Brandão, Maria Branco, Isabel Da Silva, Joana Batista, João Amado, António Massa, João Neves-Amado
INTRODUCTION: Though typically found in adolescents, acne frequently affects the adult population. In Portugal, no representative studies about acne prevalence in greater populational areas are known. This study had the following objectives: calculate acne prevalence in primary healthcare patients; its characteristics, including risk factors for onset and worsening; collect information concerning selfmedication and/or prescribed treatment. MATERIAL AND METHODS: Application of a questionnaire and physical examination into a convenience sample, composed by adults from20 - 60 years old that visited, in random days, five primary healthcare centers of the Greater Porto area...
September 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28012211/derivation-and-validation-of-a-risk-scoring-model-to-predict-advanced-colorectal-neoplasm-in-adults-of-all-ages
#20
Hyo-Joon Yang, Sungkyoung Choi, Soo-Kyung Park, Yoon Suk Jung, Kyu Yong Choi, Taesung Park, Ji Yeon Kim, Dong Il Park
BACKGROUND AND AIMS: Little is known about how to include adults < 50 years in colonoscopy screening. This study aimed to derive a risk-scoring model incorporating laboratory indicators for metabolic risks to predict advanced colorectal neoplasia (ACN) in asymptomatic Korean adults both younger and older than 50 years. METHODS: In this cross-sectional study, 70 812 consecutive adult recipients of a screening colonoscopy in a single health check-up center in Korea between 2003 and 2012 were enrolled...
July 2017: Journal of Gastroenterology and Hepatology
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