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https://www.readbyqxmd.com/read/27865981/srb1-as-a-new-redox-target-of-cigarette-smoke-in-human-sebocytes
#1
Ilaria Crivellari, Claudia Sticozzi, Giuseppe Belmonte, Ximena M Muresan, Franco Cervellati, Alessandra Pecorelli, Carlotta Cavicchio, Emanuela Maioli, Christos C Zouboulis, Mascia Benedusi, Carlo Cervellati, Giuseppe Valacchi
For its critical location, the skin represents the major interface between the body and the environment, therefore is one of the major biological barriers against the outdoor environmental stressors. Among the several oxidative environmental stressors, cigarette smoke (CS) has been associated with the development and worsening of many skin pathologies such as acne, dermatitis, delayed wound healing, aging and skin cancer. In our previous work we have demonstrated that CS is able to affect genes involved in skin cholesterol trafficking, among which SRB1, a receptor involved in the uptake of cholesterol from HDL, seems to be very susceptible to the oxidative stress induced by CS...
November 16, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27819279/concurrent-profiling-of-polar-metabolites-and-lipids-in-human-plasma-using-hilic-ftms
#2
Xiaoming Cai, Ruibin Li
Blood plasma is the most popularly used sample matrix for metabolite profiling studies, which aim to achieve global metabolite profiling and biomarker discovery. However, most of the current studies on plasma metabolite profiling focused on either the polar metabolites or lipids. In this study, a comprehensive analysis approach based on HILIC-FTMS was developed to concurrently examine polar metabolites and lipids. The HILIC-FTMS method was developed using mixed standards of polar metabolites and lipids, the separation efficiency of which is better in HILIC mode than in C5 and C18 reversed phase (RP) chromatography...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27817838/noncontraceptive-use-of-oral-combined-hormonal-contraceptives-in-polycystic-ovary-syndrome-risks-versus-benefits
#3
REVIEW
Anuja Dokras
The use of steroid sex hormones for noncontraceptive benefits has been endorsed by several medical societies. In women with polycystic ovary syndrome (PCOS), hormonal contraceptives are first-line therapy for concurrent treatment of menstrual irregularity, acne, and hirsutism. The association of PCOS with obesity, diabetes, and dyslipidemia frequently brings up the debate regarding risks versus benefits of hormonal contraceptives in this population. In women with PCOS, the lack of large-scale studies evaluating the risks with varying doses of ethinyl estradiol, types of progestins, and presence of confounding factors such as obesity, smoking, and other cardiometabolic comorbidities is a significant limitation in these deliberations...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27749646/epidemiology-of-acne-vulgaris-in-adolescent-male-students-in-arar-kingdom-of-saudi-arabia
#4
Nagah M Abo El-Fetoh, Naif G Alenezi, Nasser G Alshamari, Omar G Alenezi
BACKGROUND: Acne vulgaris is the most common cutaneous disorder affecting adolescents and young adults. Small, noninflamed acne lesions may not be more than a slight nuisance, but, in individuals with more severe inflammatory disease, pain, social embarrassment, and both physical and psychological scarring can be life altering. Despite its high prevalence, no previous community-based studies have been conducted in Arar, northern border of Kingdom of Saudi Arabia, addressing this issue...
September 2016: Journal of the Egyptian Public Health Association
https://www.readbyqxmd.com/read/27509079/acne-during-adolescence-did-not-predict-skin-rash-reaction-to-cetuximab
#5
Gil Bar-Sela, Sharon Avgush, Orit Kaidar-Person, Alex Beny, Valeriya Semenisty, Yael Liel, Reuven Bergman, Ziad Khamaysi
Cetuximab, a monoclonal antibody, is a part of the treatment for metastatic colorectal cancer. The most common side effect of cetuximab is skin rash, which has a similar distribution to acne vulgaris and some overlapping pathophysiological mechanisms. The aim of the current study was to determine whether acne vulgaris in adolescence (AinA) is predictive of a cetuximab-related rash to better understand the pathogenesis of this side effect and explore potential preventive actions. From July 2013 to June 2015, patients with metastatic colorectal cancer planned for treatment with cetuximab were enrolled in the study...
November 2016: Anti-cancer Drugs
https://www.readbyqxmd.com/read/27495143/comorbidities-treatment-and-outcome-in-severe-anogenital-inverse-acne-hidradenitis-suppurativa-a-15-year-single-center-report
#6
Uwe Wollina, Dana Langner, Birgit Heinig, Andreas Nowak
BACKGROUND: Acne inversa (hidradentitis suppurativa; AI) is a severe chronic relapsing inflammatory skin disease of unknown cause. Anogenital AI has the strongest negative impact on quality of life and causes great disability. OBJECTIVES: We analyzed patients, comorbities, outcome of extensive surgery, and possible adverse effects. PATIENTS AND METHODS: We included patients from January 2000 to March 2015 with anogenital AI Hurley grade III...
August 6, 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27473418/magnetic-solid-phase-extraction-based-on-oleic-acid-coated-fe3o4-for-the-determination-of-benzo-%C3%AE-pyrene-in-cigarette-smoke-coupled-with-high-performance-liquid-chromatography
#7
Shouai Feng, Kang Wei, Zhaofu Tian, Xiaolan Li, Dongling Meng, Wenlong Liao, Mingming Miao, Yaling Yang
In this work, a simple and effective method based on magnetic solid-phase extraction combined with high-performance liquid chromatography was developed for the determination of benzo[α]pyrene (BaP) in cigarette smoke. Oleic acid coated Fe3O4 (Fe3O4-OA) was synthesized and directly used as an efficient sorbent for the first time in magnetic solid-phase extraction (MSPE) procedure for the clean-up of BaP in cigarette smoke extracts. The synthesized Fe3O4-OA was characterized by transmission electron microscopy, X-ray diffraction and Fourier transformed infrared spectroscopy...
July 29, 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27468217/favorable-lifestyle-before-diagnosis-associated-with-lower-risk-of-screen-detected-advanced-colorectal-neoplasia
#8
Markus D Knudsen, Thomas de Lange, Edoardo Botteri, Dung-Hong Nguyen, Helge Evensen, Chloé B Steen, Geir Hoff, Tomm Bernklev, Anette Hjartåker, Paula Berstad
AIM: To investigate the association between adherence to health recommendations and detection of advanced colorectal neoplasia (ACN) in colorectal cancer (CRC) screening. METHODS: A total of 14832 women and men were invited to CRC screening, 6959 in the fecal immunochemical test arm and 7873 in the flexible sigmoidoscopy arm. These were also sent a self-reported lifestyle questionnaire to be completed prior to their first CRC screening. A lifestyle score was created to reflect current adherence to healthy behaviors in regard to smoking, body mass index, physical activity, alcohol consumption and food consumption, and ranged from zero (poorest) to six (best)...
July 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27459457/epidemiological-assessments-of-skin-outcomes-in-the-nurses-health-studies
#9
Wen-Qing Li, Eunyoung Cho, Martin A Weinstock, Hasan Mashfiq, Abrar A Qureshi
OBJECTIVES: To review the contribution of the Nurses' Health Studies (NHSs) to identifying epidemiological factors associated with multiple skin diseases, including skin cancer, psoriasis, and other inflammatory and autoimmune skin diseases. METHODS: We carried out a narrative review of NHS articles published between 1976 and 2016. RESULTS: The NHSs have identified environmental and lifestyle factors related to psoriasis, supporting obesity and smoking as psoriasis risk factors; associations between psoriasis and diabetes, myocardial infarction, and Crohn's disease, supporting psoriasis as a systemic disorder; and associations of pigmentary traits, ultraviolet radiation, and lifestyle factors such as citrus consumption with risk of skin cancer...
September 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/27438194/acne-scars-in-18-year-old-male-adolescents-a-population-based-study-of-prevalence-and-associated-factors
#10
Fernanda Tcatch Lauermann, Hiram Larangeira de Almeida, Rodrigo Pereira Duquia, Paulo Ricardo Martins de Souza, Juliano de Avelar Breunig
BACKGROUND: Acne vulgaris is a pilosebaceous follicle disorder affecting over 85% of adolescents to some degree. It frequently causes psychological distress that may persist into adulthood due to scarring. Little information about post-acne scarring epidemiology is available. OBJECTIVES: To describe prevalence, distribution patterns and associated factors of acne scarring in young males, drawing on a representative population sample from a southern Brazilian city...
May 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27160843/nasal-and-conjunctival-screening-prior-to-refractive-surgery-an-observational-and-cross-sectional-study
#11
Koji Kitazawa, Chie Sotozono, Masako Sakamoto, Miho Sasaki, Osamu Hieda, Toshihide Yamasaki, Shigeru Kinoshita
OBJECTIVES: To investigate bacterial flora of clinically healthy conjunctiva and nasal cavity among patients prior to refractive surgery, as well as the characteristics of patients with methicillin-resistant Staphylococcus aureus (MRSA) colonisation. DESIGN: Observational and cross-sectional study. SETTING: A single-centre study in Japan. PARTICIPANTS: 120 consecutive patients pre-refractive surgery. PRIMARY AND SECONDARY OUTCOME MEASURES METHODS: Samples were obtained from the right conjunctival sac and the nasal cavity of 120 consecutive patients prior to refractive surgery and were then measured for the levels of the minimum inhibitory concentration (MIC) of antibiotics...
2016: BMJ Open
https://www.readbyqxmd.com/read/27088931/quality-of-life-in-acne-vulgaris-relationship-to-clinical-severity-and-demographic-data
#12
Aayush Gupta, Yugal Kishor Sharma, Kedar Nath Dash, Nitin Dinkar Chaudhari, Sumit Jethani
BACKGROUND: Acne vulgaris is known to impair many aspects of quality of life. However, the correlation of this impairment with clinical severity remains equivocal despite various school, community and hospital-based studies. AIM: A hospital-based study was undertaken to measure the impairment of quality of life of patients of acne vulgaris and correlate it with the severity of lesions. METHODS: This was a cross-sectional, questionnaire-based study in a cohort of 100 patients of acne vulgaris attending the outpatient department of our referral hospital...
May 2016: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/27038247/vedolizumab-induction-therapy-for-inflammatory-bowel-disease-in-clinical-practice-a-nationwide-consecutive-german-cohort-study
#13
D C Baumgart, B Bokemeyer, A Drabik, A Stallmach, S Schreiber
BACKGROUND: Vedolizumab (VDZ) is a humanised monoclonal IgG1 antibody targeting α4 β7 integrin. AIM: To investigate the real-world efficacy of vedolizumab for the treatment of Crohn's disease (CD) and ulcerative colitis (UC). METHODS: A consecutive cohort of 212 adult IBD patients with active disease (HBI >7/partial Mayo >4) newly receiving VDZ was prospectively recruited from 7 academic and 17 community centres. The primary endpoint was clinical remission (CRM) (CD HBI ≤4, UC pMayo ≤1) in week 14...
May 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27028361/dermatological-aspects-of-synthetic-cannabinoid-addiction
#14
Rahime Inci, Kiymet Handan Kelekci, Nihan Oguz, Semsettin Karaca, Baris Karadas, Adem Bayrakci
CONTEXT: Synthetic cannabinoids have recently become one of the most abused substances among young population and have caused severe health consequences in our country and worldwide. OBJECTIVE: The aim of this study was to investigate sociodemographic and dermatological findings in SC addicts Materials and Methods: A total of 136 SC user who applied to our hospital's Substance Dependence Center outpatient clinic and diagnosed with drug addiction according to DSM-4 criteria between July 2014 and September 2015 were enrolled to our study...
March 30, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/26977757/risk-of-colorectal-neoplasia-in-individuals-with-self-reported-family-history-a-prospective-colonoscopy-study-from-16-asia-pacific-regions
#15
Martin C S Wong, Jessica Y L Ching, Han-Mo Chiu, Kai Chun Wu, Rungsun Rerknimitr, Jingnan Li, Deng-Chiang Wu, Khean Lee Goh, Takahisa Matsuda, Hyun-Soo Kim, Rupert Leong, Khay Guan Yeoh, Vui Heng Chong, Jose D Sollano, Furqaan Ahmed, Jayaram Menon, Siew C Ng, Justin C Y Wu, Francis K L Chan, Joseph J Y Sung
OBJECTIVES: We tested the hypothesis that the risk of colorectal cancer (CRC), advanced colorectal neoplasia (ACN), and colorectal adenoma among screening participants with different first-degree relatives (FDRs) affected by CRC was similar. METHODS: A multi-center, prospective colonoscopy study involving 16 Asia-Pacific regions was performed from 2008 to 2015. Consecutive self-referred CRC screening participants aged 40-70 years were recruited, and each subject received one direct optical colonoscopy...
March 15, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/26765131/quality-of-life-in-acne-vulgaris-relationship-to-clinical-severity-and-demographic-data
#16
Aayush Gupta, Yugal Kishor Sharma, Kedar Nath Dash, Nitin Dinkar Chaudhari, Sumit Jethani
BACKGROUND: Acne vulgaris is known to impair many aspects of quality of life. However, the correlation of this impairment with clinical severity remains equivocal despite various school, community and hospital-based studies. AIM: A hospital-based study was undertaken to measure the impairment of quality of life of patients of acne vulgaris and correlate it with the severity of lesions. METHODS: This was a cross-sectional, questionnaire-based study in a cohort of 100 patients of acne vulgaris attending the outpatient department of our referral hospital...
January 14, 2016: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/26653298/hidradenitis-suppurativa-a-guide-for-the-practicing-physician
#17
REVIEW
Carina M Woodruff, Abbas M Charlie, Kieron S Leslie
Hidradenitis suppurativa is a chronic inflammatory disease of apocrine gland-bearing skin. Although immunologic derangements, genetic predisposition, obesity, and smoking are likely important factors, the pathogenesis of the disease and the effect of available treatments on disease course have not been fully elucidated. In the absence of proper treatment, chronic inflammation results in diffuse scarring and a wide array of complications, including the development of cutaneous squamous cell carcinoma. This severe and chronic disease can have detrimental effects on self-esteem and quality of life...
December 2015: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/26472098/a-randomized-comparative-trial-of-a-combined-oral-contraceptive-and-azelaic-acid-to-assess-their-effect-on-sleep-quality-in-adult-female-acne-patients
#18
RANDOMIZED CONTROLLED TRIAL
Rachel Gimenes Albuquerque, Marco Alexandre Dias da Rocha, Camila Hirotsu, Helena Hachul, Edileia Bagatin, Sergio Tufik, Monica Levy Andersen
Several studies have reported an increase in the prevalence of adult female acne. This subtype of acne presents particular characteristics, and can be triggered by several factors such as smoking, stress, the use of oily cosmetics and even by poor sleep. Sleep quality is related to well-being and the maintenance of body homeostasis. In addition, several skin diseases present a bidirectional relationship with sleep, demonstrating an important connection between skin and the central nervous system. With this in mind, we aimed to compare the effect of two types of treatment for adult female acne (azelaic acid or a combined oral contraceptive) on sleep quality and on concentrations of stress hormones...
December 2015: Archives of Dermatological Research
https://www.readbyqxmd.com/read/26470623/pathophysiology-of-hidradenitis-suppurativa-an-update
#19
REVIEW
Errol Prens, Inge Deckers
The pathogenesis of hidradenitis suppurativa (HS) or acne inversa is not completely understood. Recent research has led to greater insight into the mechanisms involved in the disease. The primary defect in HS pathophysiology rests with the hair follicle. Follicular occlusion, followed by follicular rupture, and a foreign body-type immune response are necessary conditions for the development of clinical HS. A specific genetic signature and environmental factors, such as cigarette smoking, microbial colonization, and adiposity, all contribute to the HS phenotype...
November 2015: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/26360246/occluded-cigarette-smoke-exposure-causing-localized-chloracne-like-comedones
#20
Andrew T Patterson, Frances T Tian, Dirk M Elston, Benjamin H Kaffenberger
Many environmental acne disorders, including chloracne and oil acne, were previously thought to occur predominantly in occupational settings following polycyclic aromatic hydrocarbon exposure. Cigarette smoke has also been shown to contain a large number of these toxic polycyclic aromatic hydrocarbon components and strictly correlates with noninflammatory acneiform lesion development in postadolescent patients. We report a case of localized open comedones associated with occluded cigarette smoke exposure near the nasal cavity due to infrequently changed gauze following rhinectomy...
2015: Dermatology: International Journal for Clinical and Investigative Dermatology
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