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https://www.readbyqxmd.com/read/30402930/active-vaccination-against-interleukin-5-as-long-term-treatment-for-insect-bite-hypersensitivity-in-horses
#1
Antonia Fettelschoss-Gabriel, Victoria Fettelschoss, Florian Olomski, Katharina Birkmann, Franziska Thoms, Maya Bühler, Martin Kummer, Andris Zeltins, Thomas M Kündig, Martin F Bachmann
BACKGROUND: Insect-bite hypersensitivity (IBH) in horses is a chronic allergic dermatitis caused by insect bites. Horses suffer from pruritic skin lesions, caused by type-I/type-IV allergic reactions accompanied by prominent eosinophil infiltration into the skin. Interleukin-5 (IL-5) is the key cytokine for eosinophils and we have previously shown that targeting IL-5 by vaccination reduces disease symptoms in horses. OBJECTIVE: Here we analyzed the potential for long-term therapy by assessing a second follow-up year of the previously published study...
November 7, 2018: Allergy
https://www.readbyqxmd.com/read/30380950/cause-or-prevention-of-breast-cancer-with-estrogens-analysis-from-tumor-biologic-data-growth-kinetic-model-and-women-s-health-initiative-study
#2
R J Santen, W Yue
The existing medical literature suggests that estrogens may cause breast cancer but, paradoxically, can also prevent this neoplasm under specific circumstances. Appropriate interpretation of this complex data requires an understanding of emerging concepts of tumor biology. A substantial body of data, including animal models and epidemiologic studies, suggests that estrogens contribute to the development of breast cancer. Additionally, pre-clinical experiments indicate that the responsible mechanisms include both estrogen receptor α-dependent and -independent effects (ERα-dependent and ERα-independent effects)...
November 1, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/30380948/effects-of-different-menopausal-hormone-replacement-regimens-on-body-composition-in-chinese-women
#3
Y Deng, W Xue, Y Wang, S Zhu, X Ma, A Sun
PURPOSE: The aim of this study was to determine the effects of different menopausal hormone therapy regimens on body composition in healthy postmenopausal Chinese women. MATERIALS AND METHODS: One hundred and twenty-three healthy postmenopausal Chinese women were randomly assigned to either group A (0.625 mg conjugated equine estrogens [CEE] plus 100 mg micronized progesterone [MP]), group B (0.3 mg CEE plus 100 mg MP), or group C (0.625 mg CEE plus 10 mg dydrogesterone)...
October 31, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/30364519/assessing-the-risk-for-major-injuries-in-equestrian-sports
#4
Lara Krüger, Maike Hohberg, Wolfgang Lehmann, Klaus Dresing
Background/aim: Horse riding is a popular sport, which bears the risk of serious injuries. This study aims to assess whether individual factors influence the risk to sustain major injuries. Methods: Retrospective data were collected from all equine-related accidents at a German Level I Trauma Centre between 2004 and 2014. Logistic regression was used to identify the risk factors for major injures. Results: 770 patients were included (87.9% females)...
2018: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/30358724/hot-flushes-coronary-heart-disease-and-hormone-therapy-in-postmenopausal-women
#5
Alison J Huang, George F Sawaya, Eric Vittinghoff, Feng Lin, Deborah Grady
OBJECTIVE: The aim of this study was to examine interactions between hot flushes, estrogen plus progestogen therapy (EPT), and coronary heart disease (CHD) events in postmenopausal women with CHD. METHODS: We analyzed data from the Heart and Estrogen/Progestin Replacement Study, a randomized, placebo-controlled trial of 0.625 mg conjugated equine estrogens plus 2.5 mg medroxyprogesterone acetate in 2,763 postmenopausal women with CHD. Hot flushes were assessed at baseline using self-administered questionnaires; women reporting bothersome hot flushes "some" to "all" of the time were considered to have clinically significant flushing...
November 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30358716/comparison-of-the-antioxidant-effects-of-equine-estrogens-red-wine-components-vitamin-e-and-probucol-on-low-density-lipoprotein-oxidation-in-postmenopausal-women
#6
Bhagu R Bhavnani, Anthony Cecutti, Alan Gerulath, Allan C Woolever, Mauricio Berco
OBJECTIVE: Oxidized low-density lipoprotein (LDL) seems to play an important role in the etiology of atherosclerosis. To further study this, we performed two studies: (1) we determined the ability of 10 estrogen components of the drug, conjugated equine estrogen (CEE), trans-resveratrol (t-resveratrol) and quercetin (red wine components), trolox (vitamin E analog), and probucol (a serum cholesterol-lowering drug) to delay or prevent the oxidation of plasma LDL isolated from untreated postmenopausal women, and (2) we assessed the effect of long-term (>1 year) estrogen replacement therapy and hormone replacement therapy on LDL oxidation by ex vivo methods...
November 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30358715/17%C3%AE-estradiol-vaginal-tablet-versus-conjugated-equine-estrogen-vaginal-cream-to-relieve-menopausal-atrophic-vaginitis
#7
Jacques Emile Rioux, M Corinne Devlin, Morrie M Gelfand, Wilfred M Steinberg, Douglas S Hepburn
OBJECTIVES: The efficacy and safety of 25-μg 17β-estradiol vaginal tablets (Vagifem) were assessed and compared with 1.25-mg conjugated equine estrogen vaginal cream (Premarin Vaginal Cream) for the relief of menopausal-derived atrophic vaginitis, resulting from estrogen deficiency. DESIGN: In a multicenter, open-label, randomized, parallel-group study, 159 menopausal women were treated for 24 weeks with either vaginal tablets or vaginal cream. Efficacy was evaluated by relief of vaginal symptoms and concentrations of serum estradiol and follicle-stimulating hormone...
November 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/30342803/medical-therapy-in-equine-wound-management
#8
REVIEW
R Reid Hanson
Suitable use of prophylactic antimicrobial drugs for wounds depends on the accurate selection of appropriate antibiotics, dosing regimen, and duration of use. Regional intravenous delivery and intraosseous infusion of antibiotics are pivotal to a successful outcome for deep-rooted infections, inadequately perfused tissue, and infected wounds containing biofilm. Antibiotic-impregnated polymethylmethacrylate beads are predominantly helpful for wounds that have a poor blood supply and for those containing surgical implants that must remain in place...
October 17, 2018: Veterinary Clinics of North America. Equine Practice
https://www.readbyqxmd.com/read/30319932/effects-of-equine-therapy-on-individuals-with-autism-spectrum-disorder-a-systematic-review
#9
Sudha M Srinivasan, David T Cavagnino, Anjana N Bhat
Literature on effects of equine therapy in individuals with autism spectrum disorder (ASD) has grown in recent times. Equine therapy is an alternative multimodal intervention that involves utilizing a horse to enhance core impairments in ASD. Recent systematic reviews in this area have several limitations including inclusion of populations other than ASD, assessment of a variety of animal-assisted interventions other than equine therapy, and a failure to conduct quantitative analyses to provide accurate effect size estimates...
June 2018: Review journal of autism and developmental disorders
https://www.readbyqxmd.com/read/30311630/lentiviral-based-reporter-constructs-for-profiling-chondrogenic-activity-in-primary-equine-cell-populations
#10
A Martin-Pena, R M Porter, G Plumton, T M McCarrel, A J Morton, M V Guijarro, S C Ghivizzani, B Sharma, G D Palmer
Successful clinical translation of mesenchymal stem cell (MSC)-based therapies for cartilage repair will likely require the implementation of standardised protocols and broadly applicable tools to facilitate the comparisons among cell types and chondroinduction methods. The present study investigated the utility of recombinant lentiviral reporter vectors as reliable tools for comparing chondrogenic potential among primary cell populations and distinguishing cellular-level variations of chondrogenic activity in widely used three-dimensional (3D) culture systems...
October 12, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/30308266/human-versus-non-human-sex-steroid-use-in-hormone-replacement-therapies-part-1-preclinical-data
#11
REVIEW
Craig S Atwood, Samuel F Ekstein
Prior to 2002, hormone replacement therapy (HRT) was considered to be an important component of postmenopausal healthcare. This was based on a plethora of basic, epidemiological and clinical studies demonstrating the health benefits of supplementation with human sex steroids. However, adverse findings from the Women's Health Initiative (WHI) studies that examined the 2 major forms of HRT in use in the US at that time - Premarin (conjugated equine estrogens; CEE) and Prempro (CEE + medroxyprogesterone acetate; MPA), cast a shadow over the use of any form of HRT...
October 8, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/30296850/menopausal-hormone-therapy-and-breast-cancer-what-is-the-evidence-from-randomized-trials
#12
H N Hodis, P M Sarrel
The relationship between menopausal hormone therapy (HT) and breast cancer is complex and further complicated by misinformation, perception, and overgeneralization of data. These issues are addressed in this mini-review through the lens of the Women's Health Initiative (WHI) that has colored the view of HT and breast cancer. In the WHI, unopposed conjugated equine estrogen (CEE) reduced breast cancer risk and mortality. In the WHI CEE plus continuously combined medroxyprogesterone acetate (MPA) trial, although the hazard ratio (HR) was elevated it was statistically non-significant for an association between CEE + MPA and breast cancer...
October 9, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/30294851/equine-asthma-integrative-biologic-relevance-of-a-recently-proposed-nomenclature
#13
REVIEW
Stephanie Bond, Renaud Léguillette, Eric A Richard, Laurent Couetil, Jean-Pierre Lavoie, James G Martin, R Scott Pirie
The term "equine asthma" has been proposed as a unifying descriptor of inflammatory airway disease (IAD), recurrent airway obstruction (RAO), and summer pasture-associated obstructive airway disease. Whilst the term will increase comprehensibility for both the lay and scientific communities, its biologic relevance must be compared and contrasted to asthma in human medicine, recognizing the limited availability of peer-reviewed equine-derived data, which are largely restricted to clinical signs, measures of airway obstruction and inflammation and response to therapy...
October 7, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/30289445/dysregulation-of-cortisol-metabolism-in-equine-pituitary-pars-intermedia-dysfunction
#14
Ruth A Morgan, John A Keen, Natalie Homer, Mark Nixon, Anna M McKinnon-Garvin, Jodie A Moses-Williams, Sarah R Davis, Patrick W F Hadoke, Brian R Walker
Equine Cushing disease [pituitary pars intermedia dysfunction (PPID)] is a common condition of older horses, but its pathophysiology is complex and poorly understood. In contrast to pituitary-dependent hyperadrenocorticism in other species, PPID is characterized by elevated plasma ACTH but not elevated plasma cortisol. In this study, we address this paradox and the hypothesis that PPID is a syndrome of ACTH excess in which there is dysregulation of peripheral glucocorticoid metabolism and binding. In 14 horses with PPID compared with 15 healthy controls, we show that in plasma, cortisol levels and cortisol binding to corticosteroid binding globulin were not different; in urine, glucocorticoid and androgen metabolites were increased up to fourfold; in liver, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) expression was reduced; in perirenal adipose tissue, 11β-HSD1 and carbonyl reductase 1 expression was increased; and tissue cortisol levels were not measurably different...
November 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/30287778/assessment-of-a-rabies-virus-rapid-diagnostic-test-for-the-detection-of-australian-bat-lyssavirus
#15
Andrea Certoma, Ross A Lunt, Wilna Vosloo, Ina Smith, Axel Colling, David T Williams, Thao Tran, Stuart D Blacksell
Australian bat lyssavirus (ABLV) is closely related to the classical rabies virus and has been associated with three human fatalities and two equine fatalities in Australia. ABLV infection in humans causes encephalomyelitis, resulting in fatal disease, but has no effective therapy. The virus is maintained in enzootic circulation within fruit bats ( Pteropid spp.) and at least one insectivorous bat variety ( Saccolaimus flaviventris ). Most frequently, laboratory testing is conducted on pteropodid bat brains, either following a potential human exposure through bites, scratches and other direct contacts with bats, or as opportunistic assessment of sick or dead bats...
October 4, 2018: Tropical Medicine and Infectious Disease
https://www.readbyqxmd.com/read/30267998/evaluation-of-the-antiviral-activities-of-bacharis-dracunculifolia-and-quercetin-on-equid-herpesvirus-1-in-a-murine-model
#16
Caroline Gracielle Torres Ferreira, Mateus Gandra Campos, Daniele Mendes Felix, Marcus Rebouças Santos, Otávio Valério de Carvalho, Marisa Alves Nogueira Diaz, Juliana Lopes Rangel Fietto, Gustavo Costa Bressan, Abelardo Silva-Júnior, Márcia Rogéria de Almeida
Equid herpesvirus 1 (EHV-1) is a pathogen of high economic importance in equine breeding operations around the world. EHV-1 infection causes respiratory, neurologic and reproductive disease. The absence of an efficient therapy has caught the attention of the scientific community and the therapeutic activities of natural products with its antivirals effects might be effective for the disease's treatment. Herein it was evaluated the prophylactic and therapeutic potential of quercetin and ethanolic extracts of Bacharis dracunculifolia formulations compared to Penciclovir® in an in vivo EHV-1 infection model...
October 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/30267793/horses-referred-to-a-teaching-hospital-exclusively-for-acupuncture-and-herbs-a-three-year-retrospective-analysis
#17
Justin Shmalberg, Huisheng Xie, Mushtaq A Memon
Equine acupuncture and herbal medicine are increasingly popular and have been anecdotally used in the treatment of a number of conditions. There is, however, a lack of data on the most commonly treated conditions in horses. The medical records of 164 horses presented exclusively for acupuncture and herbal therapy over a three-year period from October 2012 to October 2015 were evaluated from a mixed animal integrative medicine service at a veterinary academic teaching hospital. Horses were presented primarily for musculoskeletal conditions (62...
September 26, 2018: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/30260975/evaluation-of-an-equine-assisted-therapy-program-for-veterans-who-identify-as-wounded-injured-or-ill-and-their-partners
#18
Madeline Romaniuk, Justine Evans, Chloe Kidd
The aim of this study was to evaluate outcomes of an equine-assisted therapy program for Defence Force veterans and their partners across the psychological domains of depression, anxiety, stress, posttraumatic stress, happiness, and quality of life, as well as compare the outcomes of an Individual and Couples program. A non-controlled, within-subjects longitudinal design was utilized with assessment at three time points (pre-intervention, post-intervention, and three months follow-up). Between-subjects analysis with two groups was also conducted to compare the outcomes of the Individual and Couples programs...
2018: PloS One
https://www.readbyqxmd.com/read/30253849/anthelmintic-drugs-used-in-equine-species
#19
REVIEW
Cengiz Gokbulut, Quintin A McKellar
Internal parasites of horses comprise an intractable problem conferring disease, production and performance losses. Parasitism can rarely be controlled in grazing horses by management alone and anthelmintic drugs have formed the basis of therapy and prophylaxis for the last sixty years. The pharmacology of the anthelmintic drugs available dictate their spectrum of activity and degree of efficacy, their optimal routes of administration and characteristics which prevent some routes of administration, their safety tolerance and potential toxicities and as a consequence of their persistence in the body at effective concentrations their use in epidemiological control programmes...
September 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/30251918/cell-identity-proliferation-and-cytogenetic-assessment-of-equine-umbilical-cord-blood-mesenchymal-stromal-cells
#20
Amir H Alizadeh, Ritesh Briah, Daniel A F Villagómez, Allan King, Thomas G Koch
The aim of the present work was to determine proliferation capacity, immunophenotype and genome integrity of mesenchymal stromal cells (MSCs) from horse umbilical cord blood (UCB) at passage stage 5 and 10. Passage four cryopreserved UCB-MSCs from six unrelated donors were evaluated. Immunophenotypic analysis of UCB-MSC revealed a cell identity consistent with equine MSC phenotype by high expression of CD90, CD44, CD29 and very low expression of CD4, CD11a/18, CD73, and MHC class I and II antigens. Proliferative differences were noted among the UCB-MSC cultures...
September 25, 2018: Stem Cells and Development
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