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https://www.readbyqxmd.com/read/29776607/differentiation-of-equine-bone-marrow-derived-mesenchymal-stem-cells-increases-the-expression-of-immunogenic-genes
#1
Laura Barrachina, Ana Rosa Remacha, Antonio Romero, Pilar Zaragoza, Francisco José Vázquez, Clementina Rodellar
Mesenchymal stem cells (MSCs) are a promising treatment for equine musculoskeletal injuries because of their ability to regulate the inflammation and to differentiate into other cell types. Since interest in allogeneic therapy is rising, concerns about MSC immunogenicity need to be addressed. Differentiated MSCs from several species increase their expression of immunogenic molecules and induce alloresponses, but equine MSC immunogenic profile after differentiation has not been reported. Therefore, the aim of this study was to assess the gene expression of immunogenic markers in tri-lineage differentiated equine bone marrow derived MSCs (eBM-MSCs)...
June 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29768475/conjugated-equine-estrogen-and-medroxyprogesterone-acetate-are-associated-with-decreased-risk-of-breast-cancer-relative-to-bioidentical-hormone-therapy-and-controls
#2
Zexian Zeng, Xia Jiang, Xiaoyu Li, Alan Wells, Yuan Luo, Richard Neapolitan
OBJECTIVE: By the 1990s it became popular for women to use hormone therapy (HT) to ease menopause symptoms. Bioidentical estrogen and progesterone are supplements whose molecular structures are identical to what is made in the human body, while synthetic supplements are ones whose structures are not. After the Women's Health Initiative found that the combined use of the synthetics conjugated equine estrogen (CEE) and medroxyprogesterone acetate (MPA) increased breast cancer risk, prescriptions for synthetic HT declined considerably...
2018: PloS One
https://www.readbyqxmd.com/read/29747269/-effect-of-low-dose-or-standard-dose-conjugated-equine-estrogen-combined-with-different-progesterone-on-bone-density-in-menopause-syndrome-women
#3
H L Zuo, Y Deng, Y F Wang, L L Gao, W Xue, S Y Zhu, X Ma, A J Sun
Objective: To explore the effect of low-dose or standard-dose conjugated equine estrogen (CEE) combined with natural progesterone or dydrogesterone on bone density in menopause syndrome women. Methods: Totally 123 patients with menopause syndrome were recruited and randomly assigned to 3 treatment groups: group A (low-dose CEE+progesterone) , group B (standard-dose CEE+progesterone) , group C (standard-dose CEE+dydrogesterone) . Using continuous sequential regimen, the duration of intervention was 12 cycles...
April 25, 2018: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29738414/estrogen-alone-therapy-and-invasive-breast-cancer-incidence-by-dose-formulation-and-route-of-delivery-findings-from-the-whi-observational-study
#4
Chrisandra Shufelt, C Noel Bairey Merz, Mary B Pettinger, Lydia Choi, Rowan Chlebowski, Carolyn J Crandall, Simin Liu, Dorothy Lane, Ross Prentice, JoAnn E Manson
OBJECTIVE: Research on the relationships between different hormone therapy doses, formulation and routes of delivery, and subsequent breast cancer incidence has been limited. This study directly compared different estrogen doses, formulations, and route of delivery of estrogen alone among women with a hysterectomy in relation to invasive breast cancer incidence. METHODS: The Women's Health Initiative Observational Study is a large multicenter prospective cohort study conducted at 40 US sites...
May 7, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29738412/slco1b1-genetic-variation-and-hormone-therapy-in-menopausal-women
#5
Ann M Moyer, Mariza de Andrade, Stephanie S Faubion, Ekta Kapoor, Tanda Dudenkov, Richard M Weinshilboum, Virginia M Miller
OBJECTIVE: Response to menopausal hormone therapy (MHT) shows individual variation. SLCO1B1 encodes the OATP1B1 transporter expressed in the liver that transports many endogenous substances, including estrone sulfate, from the blood into hepatocytes. This study evaluated the relationship between genetic variation in SLCO1B1 and response to MHT in women enrolled in the Kronos Early Estrogen Prevention Study (KEEPS) at Mayo Clinic, Rochester, MN. METHODS: KEEPS participants were randomized to oral conjugated equine estrogen (n = 33, oCEE), transdermal 17β-estradiol (n = 33, tE2), or placebo (n = 34) for 48 months...
May 7, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29723345/low-estrogen-doses-normalize-testosterone-and-estradiol-levels-to-the-female-range-in-transgender-women
#6
Flávia Siqueira Cunha, Sorahia Domenice, Maria Helena Palma Sircili, Berenice Bilharinho de Mendonca, Elaine Maria Frade Costa
OBJECTIVE: The ideal dosage of cross-sex hormones remains unknown. The aim of this study was to evaluate the luteinizing hormone, follicle-stimulating hormone, testosterone, estradiol and prolactin levels after low-dose estrogen therapy with or without cyproterone acetate in transgender women. METHODS: The serum hormone and biochemical profiles of 51 transgender women were evaluated before gonadectomy. Hormone therapy consisted of conjugated equine estrogen alone or combined with cyproterone acetate...
2018: Clinics
https://www.readbyqxmd.com/read/29722121/in-vivo-confocal-microscopy-characteristics-of-equine-epithelial-and-subepithelial-nonulcerative-keratomycosis
#7
Eric C Ledbetter, Nita L Irby, Leandro B C Teixeira
OBJECTIVE: To describe the in vivo confocal microscopy features of horses with epithelial and subepithelial nonulcerative keratomycosis. ANIMALS STUDIED: Four horses with a clinical diagnosis of epithelial or subepithelial keratomycosis. PROCEDURES: Horses were examined on one or more occasions by in vivo laser scanning confocal microscopy of the cornea. Confocal microscopic examination characteristics were correlated with clinical, cytological, and histopathological findings for the horses...
May 2, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29721754/effects-of-three-dimensional-spheroid-culture-on-equine-mesenchymal-stem-cell-plasticity
#8
Mi Jeong Park, Jienny Lee, Jeong Su Byeon, Da-Un Jeong, Na-Yeon Gu, In-Soo Cho, Sang-Ho Cha
Mesenchymal stem cells (MSCs) are useful candidates for tissue engineering and cell therapy fields. We optimize culture conditions of equine adipose tissue-derived MSCs (eAD-MSCs) for treatment of horse fractures. To investigate enhancing properties of three-dimensional (3D) culture system in eAD-MSCs, we performed various sized spheroid formation and determined changes in gene expression levels to obtain different sized spheroid for cell therapy. eAD-MSCs were successfully isolated from horse tailhead. Using hanging drop method, spheroid formation was generated for three days...
May 2, 2018: Veterinary Research Communications
https://www.readbyqxmd.com/read/29713634/cell-based-therapies-for-joint-disease-in-veterinary-medicine-what-we-have-learned-and-what-we-need-to-know
#9
REVIEW
Sophie Helen Bogers
Biological cell-based therapies for the treatment of joint disease in veterinary patients include autologous-conditioned serum, platelet-rich plasma, and expanded or non-expanded mesenchymal stem cell products. This narrative review outlines the processing and known mechanism of action of these therapies and reviews current preclinical and clinical efficacy in joint disease in the context of the processing type and study design. The significance of variation for biological activity and consequently regulatory approval is also discussed...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29698054/effects-of-equine-assisted-activities-and-therapies-on-the-affective-network-of-adolescents-with-internet-gaming-disorder
#10
Kyoung Doo Kang, Tae Woon Jung, In Hui Park, Doug Hyun Han
OBJECTIVES: Internet gaming disorder (IGD) has been suggested to be a mental health disorder. Attachment and emotional status in IGD patients are important for understanding the etiology and progression of IGD because both parameters are considered to be associated with the affective network. Equine-assisted activities and therapies (EAAT) have been reported to improve emotional status and attachment in subjects. We hypothesized that EAAT would improve attachment in IGD adolescents with insecure attachment issues and increase functional connectivity (FC) within the affective network...
April 26, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29665126/prophylactic-therapy-with-omeprazole-for-prevention-of-equine-gastric-ulcer-syndrome-egus-in-horses-in-active-training-a-meta-analysis
#11
L V Mason, J R Moroney, R J Mason
BACKGROUND: Guidelines regarding the impact and value of prophylaxis or maintenance therapy in Equine Gastric Ulcer Syndrome (EGUS) are not well established or defined. The merits and the magnitude of effects of prophylaxis for spontaneous or recurrent squamous gastric ulceration in horses in training are uncertain. OBJECTIVES: To pool data from randomised controlled trials (RCTs) to eliminate reporting bias and evaluate the efficacy of prophylactic omeprazole in the prevention of EGUS in training horses, and secondarily to compare prophylactic dosages of omeprazole...
April 17, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29661902/brain-structure-and-cognition-3-years-after-the-end-of-an-early-menopausal-hormone-therapy-trial
#12
Kejal Kantarci, Nirubol Tosakulwong, Timothy G Lesnick, Samantha M Zuk, Val J Lowe, Julie A Fields, Jeffrey L Gunter, Matthew L Senjem, Megan L Settell, Carey E Gleason, Lynne T Shuster, Kent R Bailey, N Maritza Dowling, Sanjay Asthana, Clifford R Jack, Walter A Rocca, Virginia M Miller
OBJECTIVE: The effects of 2 frequently used formulations of menopausal hormone therapy (mHT) on brain structure and cognition were investigated 3 years after the end of a randomized, placebo-controlled trial in recently menopausal women with good cardiovascular health. METHODS: Participants (aged 42-56 years; 5-36 months past menopause) were randomized to one of the following: 0.45 mg/d oral conjugated equine estrogen (oCEE); 50 μg/d transdermal 17β-estradiol (tE2); or placebo pills and patch for 4 years...
April 17, 2018: Neurology
https://www.readbyqxmd.com/read/29630005/an-exploration-of-equine-assisted-therapy-to-improve-balance-functional-capacity-and-cognition-in-older-adults-with-alzheimer-disease
#13
Thais Borges de Araujo, Wagner Rodrigues Martins, Marco Polo Freitas, Einstein Camargos, Jéssica Mota, Marisete Peralta Safons
BACKGROUND AND PURPOSE: Alzheimer disease (AD) is a chronic, progressive dementia syndrome that features cognitive and behavioral symptoms, as well as physical and functional limitations that develop over the course of the disease. As an activity that involves physical and cognitive aspects, equine-assisted therapy (EAT) could be a useful therapeutic approach in conditions that involve physical and cognitive decline. However, to date, there are no reports of the use of this therapy in participants with AD...
April 6, 2018: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29626656/equine-granulocytic-anaplasmosis-28-years-later
#14
REVIEW
Sehrish Saleem, Muhammad Ijaz, Shahid Hussain Farooqi, Awais Ghaffar, Ahmad Ali, Kashif Iqbal, Khalid Mehmood, Hui Zhang
Equine granulocytic anaplasmosis (EGA) is an important tick borne disease of equines that is caused by Anaplasma phagocytophilum (A. phagocytophilum). The etiological agent has veterinary as well as public health importance because of its zoonotic nature. A. phagocytophilum causes an acute illness in equines with loss of appetite, lethargy, hemorrhages and lameness. Clinically, EGA is diagnosed upon examination of morulae within neutrophils especially granulocytes in the blood. The best diagnostic tool for the detection of EGA is Polymerase chain reaction (PCR)...
April 4, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29626616/benefits-of-hippotherapy-and-horse-riding-simulation-exercise-on-healthy-older-adults-a-systematic-review
#15
REVIEW
Camille Hilliere, Daniel Collado-Mateo, Santos Villafaina, Paulo Duque-Fonseca, José A Parraça
OBJECTIVE: To provide an up-to-date research analysis on equine-assisted therapies and horse riding simulation exercise in older adults, and to suggest future directions in clinical practice and research. TYPE: Systematic review. LITERATURE SURVEY: A comprehensive search of studies was performed in 4 electronic databases (Cochrane, PubMed, PEDro, and Web of Science) regarding the effects of equine-assisted therapies and horse riding simulation exercise in older adults...
April 5, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29615127/inflammatory-licensed-equine-mscs-are-chondroprotective-and-exhibit-enhanced-immunomodulation-in-an-inflammatory-environment
#16
Jennifer M Cassano, Lauren V Schnabel, Margaret B Goodale, Lisa A Fortier
BACKGROUND: Inflammatory licensed mesenchymal stem cells (MSCs) have the ability to promote functional tissue repair. This study specifically sought to understand how the recipient tissue environment reciprocally affects MSC function. Inflammatory polarized macrophages, modeling an injured tissue environment, were exposed to licensed MSCs, and the resultant effects of MSC immunomodulation and functionality of the MSC secretome on chondrocyte homeostasis were studied. METHODS: Inflammatory licensed MSCs were generated through priming with either IFN-γ or polyinosinic:polycytidylic acid (poly I:C)...
April 3, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29601969/concepts-and-challenges-in-the-use-of-mesenchymal-stem-cells-as-a-treatment-for-cartilage-damage-in-the-horse
#17
REVIEW
Mohammed Zayed, Steve Adair, Tena Ursini, James Schumacher, Nabil Misk, Madhu Dhar
Osteoarthritis (OA), the most common form of joint disease affecting humans and horses, is characterized by the advance and decline of cartilage and loss of function of the affected joint. The progression of OA is steadily accompanied with biochemical events, which interfere with the cytokines and proteolytic enzymes responsible for progress of the disease. Recently, regenerative therapies have been used with an assumption that mesenchymal stem cells (MSCs) possess the potential to prevent the advancement of cartilage damage and potentially regenerate the injured tissue with an ultimate goal of preventing OA...
March 20, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29577272/effect-of-a-tissue-selective-estrogen-complex-tsec-on-breast-cancer-role-of-unique-properties-of-conjugated-equine-estrogen
#18
Wei Yue, Jiping Wang, Kristen A Atkins, Lisa Bottalico, Clementina Mesaros, Ian A Blair, Richard J Santen
The Women's Health Initiative studies reported that the menopausal hormone therapy (MHT) regimen containing conjugated equine estrogen (CEE) and medroxyprogesterone acetate increased, whereas CEE alone reduced breast cancer incidence. These observations suggest the possibility that CEE might exert unique actions on breast and also suggest the need to eliminate the progestogen from MHT regimens. A MHT regimen called a tissue selective estrogen complex (TSEC), containing CEE plus bazedoxifene (BZA), to avoid the need for a progestogen, was developed and FDA approved...
March 25, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29537647/differential-effects-of-estrogen-and-progestin-on-apolipoprotein-b100-and-b48-kinetics-in-postmenopausal-women
#19
Stefania Lamon-Fava, Margaret R Diffenderfer, P Hugh R Barrett, Wing Yee Wan, Borbala Postfai, Chorthip Nartsupha, Gregory G Dolnikowski, Ernst J Schaefer
The distinct effects of the estrogen and progestin components of hormonal therapy on the metabolism of apolipoprotein (apo) B-containing lipoproteins have not been studied. We enrolled eight healthy postmenopausal women in a placebo-controlled, randomized, double-blind crossover study. Each subject received placebo, conjugated equine estrogen (CEE, 0.625 mg/day) and CEE plus medroxyprogesterone acetate (MPA, 2.5 mg/day) for 8 weeks in a randomized order, with a 4-week washout between phases. Main outcomes were the fractional catabolic rate (FCR) and production rate (PR) of apo B100 in triglyceride-rich lipoproteins (TRL), intermediate-density lipoproteins (IDL) and low -density lipoprotein (LDL) and of apo B48 in TRL...
March 14, 2018: Lipids
https://www.readbyqxmd.com/read/29535784/stem-cells-for-cartilage-repair-preclinical-studies-and-insights-in-translational-animal-models-and-outcome-measures
#20
REVIEW
Melissa Lo Monaco, Greet Merckx, Jessica Ratajczak, Pascal Gervois, Petra Hilkens, Peter Clegg, Annelies Bronckaers, Jean-Michel Vandeweerd, Ivo Lambrichts
Due to the restricted intrinsic capacity of resident chondrocytes to regenerate the lost cartilage postinjury, stem cell-based therapies have been proposed as a novel therapeutic approach for cartilage repair. Moreover, stem cell-based therapies using mesenchymal stem cells (MSCs) or induced pluripotent stem cells (iPSCs) have been used successfully in preclinical and clinical settings. Despite these promising reports, the exact mechanisms underlying stem cell-mediated cartilage repair remain uncertain. Stem cells can contribute to cartilage repair via chondrogenic differentiation, via immunomodulation, or by the production of paracrine factors and extracellular vesicles...
2018: Stem Cells International
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