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https://www.readbyqxmd.com/read/30007943/in-infant-botulism-is-equine-derived-botulinum-antitoxin-eqba-an-effective-alternative-therapy-to-human-derived-botulinum-immune-globulin-big
#1
Joseph Moneim
No abstract text is available yet for this article.
July 14, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29977307/evaluation-of-oxidative-stress-and-mitophagy-during-adipogenic-differentiation-of-adipose-derived-stem-cells-isolated-from-equine-metabolic-syndrome-ems-horses
#2
Krzysztof Marycz, Christine Weiss, Agnieszka Śmieszek, Katarzyna Kornicka
Mesenchymal stem cells (MSCs) are frequently used in both human and veterinary medicine because their unique properties, such as modulating the immune response and differentiating into multiple lineages, make them a valuable tool in cell-based therapies. However, many studies have indicated the age-, lifestyle-, and disease-related deterioration of MSC regenerative characteristics. However, it still needs to be elucidated how the patient's health status affects the effectiveness of MSC differentiation. In the present study, we isolated mesenchymal stem cells from adipose tissue (adipose-derived mesenchymal stem cells (ASCs)) from horses diagnosed with equine metabolic syndrome (EMS), a common metabolic disorder characterized by pathological obesity and insulin resistance...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29960162/carnosine-as-malondialdehyde-scavenger-in-stallion-seminal-plasma-and-its-role-in-sperm-function-and-oxidative-status
#3
Carolina Camargo Rocha, Giulia Kiyomi Vechiato Kawai, João Diego de Agostini Losano, Daniel de Souza Ramos Angrimani, Bruno Rogério Rui, Luana de Cássia Bicudo, Bárbara do Carmo Simões da Silva, Maria Augusta Alonso, Camilla Mota Mendes, Mayra Elena Ortiz D'Avila Assumpção, Ricardo José Garcia Pereira, Valquíria Hyppolito Barnabe, Marcilio Nichi
Semen biotechniques may impair sperm quality due to excessive production of reactive oxygen species (ROS). Additionally, products of the oxidative reaction, especially involving lipids (e.g., malondialdehyde - MDA), may be even more harmful to sperm. Carnosine, previously reported to be present in seminal plasma of several species, may be a key factor on sperm tolerance to biotechniques by counterattacking the deleterious influence of MDA. Therefore, the aim of this study was to measure the levels of carnosine present in equine seminal plasma and relate these findings with sperm function and oxidative status during cooling and cryopreservation...
June 23, 2018: Theriogenology
https://www.readbyqxmd.com/read/29942811/international-survey-regarding-the-use-of-rehabilitation-modalities-in-horses
#4
Janine M Wilson, Erica McKenzie, Katja Duesterdieck-Zellmer
To define which biologic, electrophysical and other modalities are used in horses for injury or performance issues, a questionnaire regarding 38 modalities was distributed to eight veterinary groups. A total of 305 complete or partial responses were obtained from over 10 geographic regions; 75.4% from private equine practice or regional private equine referral hospitals, 14.1% from university teaching hospitals or satellite clinics, 8.2% from private mixed animal practice, and 2.3% from veterinary rehabilitation centers...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29927620/vulnerable-articulations-the-opportunities-and-challenges-of-illness-and-recovery
#5
Catherine Trundle, Hannah Gibson, Lara Bell
Medical anthropology overwhelmingly reveals vulnerability as a problem of powerlessness. Vulnerable groups and individuals are those exposed to the pernicious effects of inequalities, injustices, and oppressive political realities. This largely pejorative stance, we argue, simplifies the place of vulnerability within human experience and in relation to the body, health and illness. By showcasing a range of interlocking vulnerabilities, this paper reveal the spectrum of positive and negative vulnerabilities that affect health and recovery...
June 21, 2018: Anthropology & Medicine
https://www.readbyqxmd.com/read/29914685/glucocorticosteroids-administration-is-associated-with-increased-regulatory-t-cells-in-equine-asthmatic-lungs
#6
Roxane Boivin, Amandine Vargas, Patricia Cano, Jean-Pierre Lavoie
Recurrent inflammation in severe equine asthma causes a remodeling of the airways leading to incompletely reversible airway obstruction. Despite the improvement of clinical signs and lung function with glucocorticoids (GC), inflammation, translated by an increased percentage of neutrophils, persists in the airways. Regulatory T cells (Treg) have been shown to have anti-inflammatory properties and play an important role in balancing the immune response by suppressing effector lymphocyte activity. However, interactions between Treg, neutrophils and glucocorticosteroids in vivo are unclear, particularly in asthma...
July 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29892605/subcutaneous-administration-of-low-molecular-weight-heparin-to-horses-inhibits-ex-vivo-equine-herpesvirus-type-1-induced-platelet-activation
#7
Tracy Stokol, Priscila B S Serpa, Marjory B Brooks, Thomas Divers, Sally Ness
Equine herpesvirus type 1 (EHV-1) is a major cause of infectious respiratory disease, abortion and neurologic disease. Thrombosis in placental and spinal vessels and subsequent ischemic injury in EHV-1-infected horses manifests clinically as abortion and myeloencephalopathy. We have previously shown that addition of heparin anticoagulants to equine platelet-rich plasma (PRP) can abolish ex vivo EHV-1-induced platelet activation. The goal of this study was to test whether platelets isolated from horses treated with unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH) were resistant to ex vivo EHV-1-induced activation...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29869540/gene-therapy-for-osteoarthritis-pharmacokinetics-of-intra-articular-self-complementary-adeno-associated-virus-interleukin-1-receptor-antagonist-delivery-in-an-equine-model
#8
Rachael S Watson Levings, Ted A Broome, Andrew D Smith, Brett L Rice, Eric P Gibbs, David A Myara, E Viktoria Hyddmark, Elham Nasri, Ali Zarezadeh, Padraic P Levings, Yuan Lu, Margaret E White, E Anthony Dacanay, Gregory B Foremny, Christopher H Evans, Alison J Morton, Mathew Winter, Michael J Dark, David M Nickerson, Patrick T Colahan, Steven C Ghivizzani
Toward the treatment of osteoarthritis (OA), the authors have been investigating self-complementary adeno-associated virus (scAAV) for intra-articular delivery of therapeutic gene products. As OA frequently affects weight-bearing joints, pharmacokinetic studies of scAAV gene delivery were performed in the joints of the equine forelimb to identify parameters relevant to clinical translation in humans. Using interleukin-1 receptor antagonist (IL-1Ra) as a secreted therapeutic reporter, scAAV vector plasmids containing codon-optimized cDNA for equine IL-1Ra (eqIL-1Ra) were generated, which produced eqIL-1Ra at levels 30- to 50-fold higher than the native sequence...
June 2018: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/29867542/detrimental-effects-of-testosterone-addition-to-estrogen-therapy-involve-cytochrome-p-450-induced-20-hete-synthesis-in-aorta-of-ovariectomized-spontaneously-hypertensive-rat-shr-a-model-of-postmenopausal-hypertension
#9
Tiago J Costa, Graziela S Ceravolo, Cinthya Echem, Carolina M Hashimoto, Beatriz P Costa, Rosangela A Santos-Eichler, Maria Aparecida Oliveira, Francesc Jiménez-Altayó, Eliana H Akamine, Ana Paula Dantas, Maria Helena C Carvalho
Postmenopausal period has been associated to different symptoms such as hot flashes, vulvovaginal atrophy, hypoactive sexual desire disorder (HSDD) and others. Clinical studies have described postmenopausal women presenting HSDD can benefit from the association of testosterone to conventional hormonal therapy. Testosterone has been linked to development of cardiovascular diseases including hypertension and it also increases cytochrome P -450-induced 20-HETE synthesis which in turn results in vascular dysfunction...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29857966/equine-manual-therapies-in-sport-horse-practice
#10
REVIEW
Kevin K Haussler
Manual therapies involve the application of the hands to the body, with a diagnostic or therapeutic intent. Touch therapies, massage, joint mobilization, and manipulation are all critical components in the management of muscular, articular, and neurologic components of select injuries in performance horses. Musculoskeletal conditions that are chronic or recurring, not readily diagnosed, or are not responding to conventional veterinary care may be indicators that manual therapy evaluation and treatment is needed...
May 29, 2018: Veterinary Clinics of North America. Equine Practice
https://www.readbyqxmd.com/read/29792391/role-of-neutrophils-in-equine-asthma
#11
Benjamin Uberti, Gabriel Morán
Neutrophilic bronchiolitis is the primary lesion in asthma-affected horses. Neutrophils are key actors in host defense, migrating toward sites of inflammation and infection, where they act as early responder cells toward external insults. However, neutrophils can also mediate tissue damage in various non-infectious inflammatory processes. Within the airways, these cells likely contribute to bronchoconstriction, mucus hypersecretion, and pulmonary remodeling by releasing pro-inflammatory mediators, including the cytokines interleukin (IL)-8 and IL-17, neutrophil elastase, reactive oxygen species (ROS), and neutrophil extracellular traps (NETs)...
May 24, 2018: Animal Health Research Reviews
https://www.readbyqxmd.com/read/29776607/differentiation-of-equine-bone-marrow-derived-mesenchymal-stem-cells-increases-the-expression-of-immunogenic-genes
#12
Laura Barrachina, Ana Rosa Remacha, Antonio Romero, Pilar Zaragoza, Francisco José Vázquez, Clementina Rodellar
Mesenchymal stem cells (MSCs) are a promising treatment for equine musculoskeletal injuries because of their ability to regulate the inflammation and to differentiate into other cell types. Since interest in allogeneic therapy is rising, concerns about MSC immunogenicity need to be addressed. Differentiated MSCs from several species increase their expression of immunogenic molecules and induce alloresponses, but equine MSC immunogenic profile after differentiation has not been reported. Therefore, the aim of this study was to assess the gene expression of immunogenic markers in tri-lineage differentiated equine bone marrow derived MSCs (eBM-MSCs)...
June 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29768475/conjugated-equine-estrogen-and-medroxyprogesterone-acetate-are-associated-with-decreased-risk-of-breast-cancer-relative-to-bioidentical-hormone-therapy-and-controls
#13
Zexian Zeng, Xia Jiang, Xiaoyu Li, Alan Wells, Yuan Luo, Richard Neapolitan
OBJECTIVE: By the 1990s it became popular for women to use hormone therapy (HT) to ease menopause symptoms. Bioidentical estrogen and progesterone are supplements whose molecular structures are identical to what is made in the human body, while synthetic supplements are ones whose structures are not. After the Women's Health Initiative found that the combined use of the synthetics conjugated equine estrogen (CEE) and medroxyprogesterone acetate (MPA) increased breast cancer risk, prescriptions for synthetic HT declined considerably...
2018: PloS One
https://www.readbyqxmd.com/read/29747269/-effect-of-low-dose-or-standard-dose-conjugated-equine-estrogen-combined-with-different-progesterone-on-bone-density-in-menopause-syndrome-women
#14
RANDOMIZED CONTROLLED TRIAL
H L Zuo, Y Deng, Y F Wang, L L Gao, W Xue, S Y Zhu, X Ma, A J Sun
Objective: To explore the effect of low-dose or standard-dose conjugated equine estrogen (CEE) combined with natural progesterone or dydrogesterone on bone density in menopause syndrome women. Methods: Totally 123 patients with menopause syndrome were recruited and randomly assigned to 3 treatment groups: group A (low-dose CEE+progesterone) , group B (standard-dose CEE+progesterone) , group C (standard-dose CEE+dydrogesterone) . Using continuous sequential regimen, the duration of intervention was 12 cycles...
April 25, 2018: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29738414/estrogen-alone-therapy-and-invasive-breast-cancer-incidence-by-dose-formulation-and-route-of-delivery-findings-from-the-whi-observational-study
#15
Chrisandra Shufelt, C Noel Bairey Merz, Mary B Pettinger, Lydia Choi, Rowan Chlebowski, Carolyn J Crandall, Simin Liu, Dorothy Lane, Ross Prentice, JoAnn E Manson
OBJECTIVE: Research on the relationships between different hormone therapy doses, formulation and routes of delivery, and subsequent breast cancer incidence has been limited. This study directly compared different estrogen doses, formulations, and route of delivery of estrogen alone among women with a hysterectomy in relation to invasive breast cancer incidence. METHODS: The Women's Health Initiative Observational Study is a large multicenter prospective cohort study conducted at 40 US sites...
May 7, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29738412/slco1b1-genetic-variation-and-hormone-therapy-in-menopausal-women
#16
Ann M Moyer, Mariza de Andrade, Stephanie S Faubion, Ekta Kapoor, Tanda Dudenkov, Richard M Weinshilboum, Virginia M Miller
OBJECTIVE: Response to menopausal hormone therapy (MHT) shows individual variation. SLCO1B1 encodes the OATP1B1 transporter expressed in the liver that transports many endogenous substances, including estrone sulfate, from the blood into hepatocytes. This study evaluated the relationship between genetic variation in SLCO1B1 and response to MHT in women enrolled in the Kronos Early Estrogen Prevention Study (KEEPS) at Mayo Clinic, Rochester, MN. METHODS: KEEPS participants were randomized to oral conjugated equine estrogen (n = 33, oCEE), transdermal 17β-estradiol (n = 33, tE2), or placebo (n = 34) for 48 months...
May 7, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29723345/low-estrogen-doses-normalize-testosterone-and-estradiol-levels-to-the-female-range-in-transgender-women
#17
Flávia Siqueira Cunha, Sorahia Domenice, Maria Helena Palma Sircili, Berenice Bilharinho de Mendonca, Elaine Maria Frade Costa
OBJECTIVE: The ideal dosage of cross-sex hormones remains unknown. The aim of this study was to evaluate the luteinizing hormone, follicle-stimulating hormone, testosterone, estradiol and prolactin levels after low-dose estrogen therapy with or without cyproterone acetate in transgender women. METHODS: The serum hormone and biochemical profiles of 51 transgender women were evaluated before gonadectomy. Hormone therapy consisted of conjugated equine estrogen alone or combined with cyproterone acetate...
2018: Clinics
https://www.readbyqxmd.com/read/29722121/in-vivo-confocal-microscopy-characteristics-of-equine-epithelial-and-subepithelial-nonulcerative-keratomycosis
#18
Eric C Ledbetter, Nita L Irby, Leandro B C Teixeira
OBJECTIVE: To describe the in vivo confocal microscopy features of horses with epithelial and subepithelial nonulcerative keratomycosis. ANIMALS STUDIED: Four horses with a clinical diagnosis of epithelial or subepithelial keratomycosis. PROCEDURES: Horses were examined on one or more occasions by in vivo laser scanning confocal microscopy of the cornea. Confocal microscopic examination characteristics were correlated with clinical, cytological, and histopathological findings for the horses...
May 2, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29721754/effects-of-three-dimensional-spheroid-culture-on-equine-mesenchymal-stem-cell-plasticity
#19
Mi Jeong Park, Jienny Lee, Jeong Su Byeon, Da-Un Jeong, Na-Yeon Gu, In-Soo Cho, Sang-Ho Cha
Mesenchymal stem cells (MSCs) are useful candidates for tissue engineering and cell therapy fields. We optimize culture conditions of equine adipose tissue-derived MSCs (eAD-MSCs) for treatment of horse fractures. To investigate enhancing properties of three-dimensional (3D) culture system in eAD-MSCs, we performed various sized spheroid formation and determined changes in gene expression levels to obtain different sized spheroid for cell therapy. eAD-MSCs were successfully isolated from horse tailhead. Using hanging drop method, spheroid formation was generated for three days...
May 2, 2018: Veterinary Research Communications
https://www.readbyqxmd.com/read/29713634/cell-based-therapies-for-joint-disease-in-veterinary-medicine-what-we-have-learned-and-what-we-need-to-know
#20
REVIEW
Sophie Helen Bogers
Biological cell-based therapies for the treatment of joint disease in veterinary patients include autologous-conditioned serum, platelet-rich plasma, and expanded or non-expanded mesenchymal stem cell products. This narrative review outlines the processing and known mechanism of action of these therapies and reviews current preclinical and clinical efficacy in joint disease in the context of the processing type and study design. The significance of variation for biological activity and consequently regulatory approval is also discussed...
2018: Frontiers in Veterinary Science
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