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https://www.readbyqxmd.com/read/28346192/menopausal-symptom-relief-and-side-effects-experienced-by-women-using-compounded-bioidentical-hormone-replacement-therapy-and-synthetic-conjugated-equine-estrogen-and-or-progestin-hormone-replacement-therapy-part-3
#1
Laura J Deleruyelle
The use of compounded bioidentical hormone replacement therapy by menopausal women has become a popular alternative to traditional synthetic conjugated equine estrogen and progestin hormone replacement therapy due to safety concerns raised by recent studies. However, due to the lack of randomized, large-scale trials to evaluate the efficacy and side-effect profile of compounded bioidentical hormone replacement therapy many healthcare providers are reluctant to prescribe such therapy. The purpose of this study was to compare women's menopausal symptom relief and side effects experienced when using compounded bioidentical hormone replacement therapy and traditional hormone replacement therapy...
January 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28342428/revealing-the-influence-of-glucocorticoid-treatment-on-the-excretion-of-anabolic-androgenic-steroids-in-horses-through-in-vitro-digestive-simulations-and-an-in-vivo-case-study
#2
Anneleen Decloedt, Sander Damen, Lynn Vanhaecke
Anabolic-androgenic steroids (AAS) are strictly forbidden in equine sports because of their stimulating effect on muscle growth and performance. Nevertheless, low levels of AAS have been found in some horses, untreated with AAS. Glucocorticoids (GC), used as an anti-inflammatory therapy and structurally related to AAS, might play a role in this phenomenon. In order to unravel this possible correlation the influence of glucocorticoid treatment on the excretion of AAS was studied both in vivo and in vitro. In vivo effects were investigated by analysing urine samples collected from a gelding treated with betamethasone...
February 24, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28339382/menopausal-symptom-relief-and-side-effects-experienced-by-women-using-compounded-bioidentical-hormone-replacement-therapy-and-synthetic-conjugated-equine-estrogen-and-or-progestin-hormone-replacement-therapy-part-2
#3
Laura J Deleruyelle
The use of compounded bioidentical hormone replacement therapy by menopausal women has become a popular alternative to traditional synthetic conjugated equine estrogen and progestin hormone replacement therapy due to safety concerns raised by recent studies. However, due to the lack of randomized, large-scale trials to evaluate the efficacy and side-effect profile of compounded bioidentical hormone replacement therapy many healthcare providers are reluctant to prescribe such therapy. The purpose of this study was to compare women's menopausal symptom relief and side effects experienced when using compounded bioidentical hormone replacement therapy and traditional hormone replacement therapy...
November 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28339370/menopausal-symptom-relief-and-side-effects-experienced-by-women-using-bioidentical-hormone-replacement-therapy-and-synthetic-conjugated-equine-estrogen-and-or-progestin-hormone-replacement-therapy-part-1
#4
Laura J Deleruyelle
The use of compounded bioidentical hormone replacement therapy by menopausal women has become a popular alternative to traditional synthetic conjugated equine estrogen and progestin hormone replacement therapy due to safety concerns raised by recent studies. However, due to the lack of randomized, large-scale trials to evaluate the efficacy and side-effect profile of compounded bioidentical hormone replacement therapy many healthcare providers are reluctant to prescribe such therapy. The purpose of this study was to compare women's menopausal symptom relief and side effects experienced when using compounded bioidentical hormone replacement therapy and traditional hormone replacement therapy...
September 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28325183/antiherpetic-drugs-in-equine-medicine
#5
REVIEW
Lara K Maxwell
Since vaccination may not prevent disease, antiherpetic drugs have been investigated for the therapy of several equine herpesviruses. Drug efficacy has been assessed in horses with disease, but most evidence is in vitro, in other species, or empirical. Oral valacyclovir is most often administered in the therapy of equine herpesvirus type-1 (EHV-1) to protect adult horses from equine herpesvirus myeloencephalopathy, while oral acyclovir is frequently administered for EHV-5 infection in the therapy of equine multinodular pulmonary fibrosis...
April 2017: Veterinary Clinics of North America. Equine Practice
https://www.readbyqxmd.com/read/28325180/compounding-of-veterinary-drugs-for-equine-practitioners
#6
REVIEW
Scott D Stanley, Krysta Moffitt, Valerie Wiebe
Equine practitioners should follow these recommendations when using compounded medications: (1) the decision must be veterinary driven, based on a valid veterinarian-client-patient relationship and on evidence-based medicine; (2) compliance with the Animal Medicinal Drug Use Clarification Act of 1994; and (3) use limited to (a) horses for which no other method or route of drug delivery is practical; (b) those drugs for which safety, efficacy, and stability have been demonstrated; or (c) disease conditions for which a quantifiable response to therapy or drug concentration can be monitored...
April 2017: Veterinary Clinics of North America. Equine Practice
https://www.readbyqxmd.com/read/28325178/corticosteroids-and-immune-suppressive-therapies-in-horses
#7
REVIEW
Mathilde Leclere
Immune suppressive therapies target exaggerated and deleterious responses of the immune system. Triggered by exogenous or endogenous factors, these improper responses can lead to immune or inflammatory manifestations, such as urticaria, equine asthma, or autoimmune and immune-mediated diseases. Glucocorticoids are the most commonly used immune suppressive drugs and the only ones supported by robust evidence of clinical efficacy in equine medicine. In some conditions, combining glucocorticoids with other pharmacologic and nonpharmacologic treatments, such as azathioprine, antihistamine, bronchodilators, environmental management, or desensitization, can help to decrease dosages and associated side effects...
April 2017: Veterinary Clinics of North America. Equine Practice
https://www.readbyqxmd.com/read/28325176/therapeutics-for-equine-gastric-ulcer-syndrome
#8
REVIEW
Fereydon Rezazadeh Zavoshti, Frank M Andrews
Equine gastric ulcer syndrome (EGUS) is an umbrella term used to describe ulcers in the nonglandular squamous and glandular mucosa, terminal esophagus, and proximal duodenum. Gastric ulcers in the squamous and glandular regions occur more often than esophageal or duodenal ulcers and likely have a different pathogenesis. At present, omeprazole is accepted globally as the best pharmacologic therapy for both regions of the stomach; however, the addition of coating agents and synthetic prostaglandins could add to its effectiveness in treatment of EGUS...
April 2017: Veterinary Clinics of North America. Equine Practice
https://www.readbyqxmd.com/read/28314783/umbilical-infections-in-foals-microbiological-investigation-and-management
#9
E Rampacci, F Passamonti, M Bottinelli, V Stefanetti, M Cercone, S Nannarone, R Gialletti, F Beccati, M Coletti, M Pepe
This study aims to investigate the bacteria involved in equine omphalitis and their susceptibility to antimicrobial drugs, and consequently to provide guidelines concerning the most suitable treatment protocol in accordance with the clinical, ultrasound and laboratory findings. Forty foals aged between one and 30 days were evaluated in the course of this investigation. An ultrasound examination of all umbilical remnants was carried out carefully in all foals; umbilical swabs were collected for bacteriological examination, and blood samples were collected for blood culture from 19 foals with fever and abnormal blood values...
March 17, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28301216/bioidentical-menopausal-hormone-therapy-registered-hormones-non-oral-estradiol%C3%A2-%C3%A2-%C3%A2-progesterone-are-optimal
#10
M L'Hermite
The many advantages of registered bioidentical sex hormones over registered, conventional, non-bioidentical menopausal hormone therapy (MHT) are considered. The transdermal route of estrogen administration avoids excess venous thromboembolic and ischemic stroke events. There is some indication that conjugated equine estrogens are more thrombogenic and most likely induce some hypertensive responses; estradiol might also be superior to conjugated equine estrogens (CEE) in terms of global cardiovascular health...
March 16, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28295526/pharmacological-treatments-in-asthma-affected-horses-a-pair-wise-and-network-meta-analysis
#11
L Calzetta, P Roncada, D di Cave, L Bonizzi, A Urbani, E Pistocchini, P Rogliani, M G Matera
BACKGROUND: Equine asthma is a disease characterised by reversible airflow obstruction, bronchial hyperresponsiveness and airway inflammation following exposure of susceptible horses to specific airborne agents. Although clinical remission can be achieved in a low-airborne dust environment, repeated exacerbations may lead to irreversible airway remodelling. The available data on the pharmacotherapy of equine asthma results from several small studies, and no head-to-head clinical trials have been conducted among the available medications...
March 10, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28281363/the-evidence-base-for-hrt-what-can-we-believe
#12
REVIEW
R D Langer
Prior to the unexpected early termination of the Women's Health Initiative (WHI) trial of continuous conjugated equine estrogens (CEE) and medroxyprogesterone acetate (MPA), the prevailing view was that hormone replacement therapy (HRT) was a low-risk intervention with immediate value for symptom relief in recently menopausal women, and that it probably conferred long-term protection against the major chronic diseases that affect women after menopause. Rather than replicating prior studies, the WHI was designed to test whether the beneficial associations consistently seen in women starting HRT near menopause would be found in women well beyond menopause...
April 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28252520/therapeutic-effects-of-horseback-riding-interventions-a-systematic-review-and-meta-analysis
#13
Alexandra Stergiou, Meropi Tzoufi, Evangelia Ntzani, Dimitrios Varvarousis, Alexandros Beris, Avraam Ploumis
OBJECTIVE: Equine-assisted therapies, such as therapeutic riding and hippotherapy, are believed to have positive physical and emotional effects in individuals with neuromotor, developmental, and physical disabilities. The purpose of this review was to determine whether therapeutic riding and hippotherapy improve balance, motor function, gait, muscle symmetry, pelvic movement, psychosocial parameters, and the patients' overall quality of life. DESIGN: In this study, a literature search was conducted on MEDLINE, CINAHL, MBASE, SportDiscus, Cochrane Database of Systematic Reviews, Cochrane Controlled Trials Register, PEDro, DARE, Google Scholar, and Dissertation Abstracts...
March 1, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28241885/repeated-intra-articular-injection-of-allogeneic-mesenchymal-stem-cells-causes-an-adverse-response-compared-to-autologous-cells-in-the-equine-model
#14
Amanda-Jo Joswig, Alexis Mitchell, Kevin J Cummings, Gwendolyn J Levine, Carl A Gregory, Roger Smith, Ashlee E Watts
BACKGROUND: Intra-articular injection of mesenchymal stem cells (MSCs) is efficacious in osteoarthritis therapy. A direct comparison of the response of the synovial joint to intra-articular injection of autologous versus allogeneic MSCs has not been performed. The objective of this study was to assess the clinical response to repeated intra-articular injection of allogeneic versus autologous MSCs prepared in a way to minimize xeno-contaminants in a large animal model. METHODS: Intra-articular injections of bone marrow-derived, culture-expanded MSCs to a forelimb metacarpophalangeal joint were performed at week 0 and week 4 (six autologous; six autologous with xeno-contamination; six allogeneic)...
February 28, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28222255/stemness-signature-of-equine-marrow-derived-mesenchymal-stem-cells
#15
Morteza Zahedi, Abbas Parham, Hesam Dehghani, Hossein Kazemi Mehrjerdi
Background: Application of competent cells such as mesenchymal stem cells (MSCs) for treatment of musculoskeletal disorders in equine athletes is increasingly needed. Moreover, similarities of horse and human in size, load and types of joint injuries, make horse as a good model for MSCs therapy studies. This study was designed to isolate and characterize stemness signature of equine bone marrow-derived mesenchymal stem cells (BM-MSCs). Methods: BM of three mares was aspirated and the mononuclear cells (MNCs) were isolated using density gradient...
February 28, 2017: International Journal of Stem Cells
https://www.readbyqxmd.com/read/28178774/a-retrospective-review-of-rattlesnake-bites-in-100-children
#16
Norberto Sotelo-Cruz, Norberto Gómez-Rivera
BACKGROUND: A retrospective review of clinical features and treatment of children hospitalized for rattlesnake bite. METHODS: One hundred clinical records were reviewed. Variables included: age, gender, season of the year, signs, symptoms, poisoning grade, complications, treatment and sequelae. RESULTS: Fifty-nine percent were males and 37% were less than 5 years of age; 87% occurred in rural areas; 63% of the snakebites occurred during the summer, of them, 39% occurred within the perimeter of the domicile and 8% within the home...
April 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28167587/snake-bite-induced-acute-kidney-injury-report-of-a-successful-outcome-during-pregnancy
#17
Sanjay Vikrant, Anupam Parashar
Snake bite is an important health hazard in tropics. Snake envenomation in pregnancy may cause fetal death and maternal mortality or morbidity. However, little is known about the toxic effects and optimal management during pregnancy after snake envenomation because of the rarity of cases. Herein, we report a case of a pregnant woman who was successfully treated for snake bite-induced acute kidney injury during the third trimester. She was treated with equine-derived polyvalent anti-snake venom without development of any adverse effects, hemodialysis, and supportive therapy...
February 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28165801/use-of-polyvalent-equine-anti-viper-serum-to-treat-delayed-coagulopathy-due-to-suspected-sistrurus-miliarius-streckeri-envenomation-in-two-children
#18
Kristie L Williams, Megan Woslager, Stephanie L Garland, Roger P Barton, William Banner
BACKGROUND: Western Pygmy Rattlesnake (WPR) envenomation reportedly causes refractory and persistent coagulopathy when treated with CroFab(®) (Crotalidae Polyvalent Immune Fab). We report two cases where polyvalent equine anti-viper serum (AntivipmynTRI(®)) was used to treat recurrent coagulopathy in children. CASE DETAILS: The first patient was a 16-month-old male who was bitten by a confirmed WPR. The patient received a total of 18 vials of CroFab(®). His labs normalized, swelling gradually improved, and the child was discharged to home...
February 6, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28147452/an-open-trial-of-equine-assisted-therapy-for-children-exposed-to-problematic-parental-substance-use
#19
Menka Tsantefski, Lynne Briggs, Jessica Griffiths, Anne Tidyman
Children exposed to problematic parental substance use (PPSU) often face a number of deleterious developmental outcomes, yet these children are less likely to become known to child protection and welfare services. Although there is a growing evidence base for equine-assisted therapy (EAT) as an effective treatment modality for atypically developing children and adolescents, scant research has explored the benefit of EAT for children exposed to PPSU. The current study is the first to explore the benefit of EAT for children exposed to PPSU in Victoria, Australia...
February 1, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28127949/glycolysis-inhibition-improves-photodynamic-therapy-response-rates-for-equine-sarcoids
#20
J P Golding, J G Kemp-Symonds, J M Dobson
Photodynamic therapy (PDT) holds great promise in treating veterinary and human dermatological neoplasms, including equine sarcoids, but is currently hindered by the amount of photosensitiser and light that can be delivered to lesions thicker than around 2 mm, and by the intrinsic antioxidant defences of tumour cells. We have developed a new PDT technique that combines an efficient transdermal penetration enhancer solution, for topical delivery of 5-aminolevulinic acid (ALA) photosensitiser, with acute topical post-PDT application of the glycolysis inhibitor lonidamine...
January 27, 2017: Veterinary and Comparative Oncology
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