keyword
https://read.qxmd.com/read/38473708/%C3%AE-h2a-%C3%AE-h2ax-mediates-dna-damage-specific-control-of-checkpoint-signaling-in-saccharomyces-cerevisiae
#1
JOURNAL ARTICLE
Jasmine Siler, Na Guo, Zhengfeng Liu, Yuhua Qin, Xin Bi
DNA lesions trigger DNA damage checkpoint (DDC) signaling which arrests cell cycle progression and promotes DNA damage repair. In Saccharomyces cerevisiae , phosphorylation of histone H2A (γH2A, equivalent to γH2AX in mammals) is an early chromatin mark induced by DNA damage that is recognized by a group of DDC and DNA repair factors. We find that γH2A negatively regulates the G2/M checkpoint in response to the genotoxin camptothecin, which is a DNA topoisomerase I poison. γH2A also suppresses DDC signaling induced by the DNA alkylating agent methyl methanesulfonate...
February 20, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38459944/elucidating-the-complex-oxidation-behavior-of-aqueous-h-3-po-3-on-pt-electrodes-via-in-situ-tender-x-ray-absorption-near-edge-structure-spectroscopy-at-the-p-k-edge
#2
JOURNAL ARTICLE
Romualdus Enggar Wibowo, Raul Garcia-Diez, Tomas Bystron, Marianne van der Merwe, Martin Prokop, Mauricio D Arce, Anna Efimenko, Alexander Steigert, Milan Bernauer, Regan G Wilks, Karel Bouzek, Marcus Bär
In situ tender X-ray absorption near-edge structure (XANES) spectroscopy at the P K -edge was utilized to investigate the oxidation mechanism of aqueous H3 PO3 on Pt electrodes under various conditions relevant to high-temperature polymer electrolyte membrane fuel cell (HT-PEMFC) applications. XANES and electrochemical analysis were conducted under different tender X-ray irradiation doses, revealing that intense radiation induces the oxidation of aqueous H3 PO3 via H2 O yielding H3 PO4 and H2 . A broadly applicable experimental procedure was successfully developed to suppress these undesirable radiation-induced effects, enabling a more accurate determination of the aqueous H3 PO3 oxidation mechanism...
March 9, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38357118/application-value-of-high-frequency-ultrasound-combined-with-ultrasonography-in-the-diagnosis-of-neonatal-esophageal-atresia
#3
JOURNAL ARTICLE
Yurong Ge, Baoyue Xu, Jing Shi, Weiwei Tang
OBJECTIVE: To explore the application value of high-frequency ultrasound combined with ultrasonography in the diagnosis of neonatal esophageal atresia (EA). METHODS: Seventy neonates with suspected EA who received healing in our hospital from August 2019 to April 2022 were retrospectively selected as the study subjects and their preoperative esophageal high-frequency ultrasound and ultrasound hydrography data were analysed. The diagnostic value of high-frequency ultrasound, ultrasound hydrography and combined detection in neonatal EA was analysed using intraoperative findings as the gold standard...
September 2023: African Health Sciences
https://read.qxmd.com/read/38346519/complete-abatement-of-the-antibiotic-ciprofloxacin-from-water-using-a-visible-light-active-nanostructured-photoanode
#4
JOURNAL ARTICLE
Katherina Changanaqui, Enric Brillas, Pere Lluís Cabot, Hugo Alarcón, Ignasi Sirés
The wide use of the fluoroquinolone antibiotic ciprofloxacin (CIP), combined with its limited removal in wastewater treatment plants, results in a dangerous accumulation in natural water. Here, the complete degradation of CIP by photoelectrocatalysis (PEC), using an FTO/ZnO/TiO2 /Ag2 Se photoanode that is responsive to blue light, has been investigated. A slow antibiotic concentration decay was found in 0.050 M Na2 SO4 under the oxidizing action of holes and ● OH photogenerated at the anode surface...
February 10, 2024: Chemosphere
https://read.qxmd.com/read/38331160/current-progress-on-manganese-in-constructed-wetlands-bibliometrics-effects-on-wastewater-treatment-and-plant-uptake
#5
REVIEW
Lingfeng Zeng, Xin Liu, Jiezhi Ma, Jie Yang, Jian Yang, Yaoyu Zhou
Constructed wetlands (CWs) are a pollutant treatment design inspired by natural wetlands and are widely utilized for the removal of common pollutants. The research focus lies in the circulation of manganese (Mn) in the environment to enhance pollutant removal within CWs. This paper provides a comprehensive review of recent advancements in understanding the role and effects of Mn in chemical weapons, based on literature retrieval from 2002 to 2021. Ecological risk assessment and heavy metals within CWs emerge as current areas of research interest...
February 6, 2024: Environmental Research
https://read.qxmd.com/read/38283822/glycyrrhizin-alleviates-radiation-induced-lung-injury-by-regulating-the-nlrp3-inflammasome-through-endoplasmic-reticulum-stress
#6
JOURNAL ARTICLE
Yuqing Chai, Ziming Wang, Yun Li, Yi Wang, Yu Wan, Xue Chen, Yang Xu, Lei Ge, Hongxia Li
OBJECTIVE: Radiation pneumonitis (RP) is the major adverse response of radiation therapy for thoracic malignant tumors, and there is a lack of effective interventions. The aim of this study was to investigate the radioprotective effect of Glycyrrhizin (GL) on RP and its potential mechanism. METHOD: The body weight and lung weight of mice were monitored. HE staining was used to observe lung injury, and the expression of endoplasmic reticulum (ER) stress biomarkers and the activation of NLRP3 inflammasome were determined by Western blotting and immunohistochemistry...
February 2024: Toxicology Research
https://read.qxmd.com/read/38273456/mortality-of-older-construction-and-craft-workers-employed-at-department-of-energy-doe-nuclear-sites-follow-up-through-2021
#7
JOURNAL ARTICLE
Knut Ringen, John Dement, Marianne Cloeren, Sammy Almashat, Stella Hines, William Grier, Patricia Quinn, Anna Chen, Scott Haas
BACKGROUND: To determine if construction and trades workers formerly employed at US Department of Energy (DOE) nuclear weapons sites are at significant risk for occupational diseases, we studied the mortality experience of participants in the Building Trades National Medical Screening Program (BTMed). METHODS: The cohort included 26,922 participants enrolled between 1998 and 2021 and 8367 deaths. Standardized mortality ratios were calculated based on US death rates...
January 25, 2024: American Journal of Industrial Medicine
https://read.qxmd.com/read/38268444/study-on-damage-of-gd-2-o-3-ceo-2-under-electronic-energy-loss-comparison-between-bulk-like-and-nanostructure
#8
JOURNAL ARTICLE
Waseem Ul Haq, V Grover, Parswajit Kalita, Rakesh Shukla, Fouran Singh, Sanjeev Kumar Srivastava, Shivam Shukla, Santanu Ghosh
To understand the physical phenomena responsible for radiation damage of the materials used in nuclear reactors, and thus study their operation life and/or efficiency, it is required to simulate the conditions by exposing the materials to energetic ions. Ceria (CeO2 ) has been proposed as one of the inert matrices for the transmutation of minor actinides in the futuristic inert matrix fuel (IMF) concept. The inert matrix should also contain burnable poison to compensate for the initial reactivity of fuel. In this context, gadolinium (Gd) is an excellent burnable poison with a high neutron absorption cross-section...
January 25, 2024: Physical Chemistry Chemical Physics: PCCP
https://read.qxmd.com/read/38242669/quasiparticle-poisoning-of-superconducting-qubits-from-resonant-absorption-of-pair-breaking-photons
#9
JOURNAL ARTICLE
C H Liu, D C Harrison, S Patel, C D Wilen, O Rafferty, A Shearrow, A Ballard, V Iaia, J Ku, B L T Plourde, R McDermott
The ideal superconductor provides a pristine environment for the delicate states of a quantum computer: because there is an energy gap to excitations, there are no spurious modes with which the qubits can interact, causing irreversible decay of the quantum state. As a practical matter, however, there exists a high density of excitations out of the superconducting ground state even at ultralow temperature; these are known as quasiparticles. Observed quasiparticle densities are of order 1  μm^{-3}, tens of orders of magnitude greater than the equilibrium density expected from theory...
January 5, 2024: Physical Review Letters
https://read.qxmd.com/read/38231175/mass-spectral-library-for-dna-adductomics
#10
JOURNAL ARTICLE
Scott J Walmsley, Jingshu Guo, Anamary Tarifa, Anthony P DeCaprio, Marcus S Cooke, Robert J Turesky, Peter W Villalta
Endogenous electrophiles, ionizing and non-ionizing radiation, and hazardous chemicals present in the environment and diet can damage DNA by forming covalent adducts. DNA adducts can form in critical cancer driver genes and, if not repaired, may induce mutations during cell division, potentially leading to the onset of cancer. The detection and quantification of specific DNA adducts are some of the first steps in studying their role in carcinogenesis, the physiological conditions that lead to their production, and the risk assessment of exposure to specific genotoxic chemicals...
January 17, 2024: Chemical Research in Toxicology
https://read.qxmd.com/read/38030008/impacts-of-climate-change-and-human-activity-on-the-potential-distribution-of-aconitum-leucostomum-in-china
#11
JOURNAL ARTICLE
Li Xu, Yuan Fan, Jianghua Zheng, Jingyun Guan, Jun Lin, Jianguo Wu, Liang Liu, Rui Wu, Yujia Liu
Aconitum leucostomum is a poisonous grass that disturbs grassland populations and livestock development, and its spread is influenced by climate change and human activities. Therefore, exploring its potential distribution area under such conditions is crucial to maintain grassland ecological security and livestock development. The present study initially selected 39 variables that may influence the spatial distribution of A. leucostomum, including bioclimate, soil, topography, solar radiation, and human footprint data; the variables were screened by Spearman's correlation coefficient and the jackknife method...
November 27, 2023: Science of the Total Environment
https://read.qxmd.com/read/37983183/online-exploring-the-gaseous-oil-fumes-from-oleic-acid-thermal-oxidation-by-synchrotron-radiation-photoionization-mass-spectrometry
#12
JOURNAL ARTICLE
Bing Qian, Yonghua Hu, Minggao Xu, Jiuzhong Yang, Chengyuan Liu, Yang Pan
Cooking oil fumes are an intricate and dynamic mixture containing a variety of poisonous and hazardous substances, and their real-time study remains challenging. Based on tunable synchrotron radiation photoionization mass spectrometry (SR-PIMS), isomeric/isobaric compounds in the gaseous oil fumes from oleic acid thermal oxidation were determined in real time and distinguished by photoionization efficiency (PIE) curve simulation combined with multiple linear regression (MLR) analysis. A series of common carcinogens such as formaldehyde, acetaldehyde, acrolein, and several unreported chemicals including diethyl ether and formylcyclohexane were successfully characterized...
November 20, 2023: Journal of the American Society for Mass Spectrometry
https://read.qxmd.com/read/37944295/do-young-children-with-known-cannabis-intoxication-benefit-from-further-neurological-based-testing-or-imaging
#13
JOURNAL ARTICLE
Amanda S Dupont, Patrick S Walsh
BACKGROUND: Recent work has demonstrated that children with unintentional cannabis ingestions often undergo extensive ancillary testing such as head imaging or lumbar puncture. To better understand the yield of these tests, our objective was to describe the frequency of additional significant diagnoses in children with cannabis ingestion. METHODS: We performed a retrospective cross-sectional study of the Pediatric Health Information System (PHIS) database, including ED encounters from January 2016 to April 2023 with a diagnosis indicating cannabis exposure in children <6 years of age...
November 2, 2023: American Journal of Emergency Medicine
https://read.qxmd.com/read/37935273/3-methylglutarylcarnitine-a-biomarker-of-mitochondrial-dysfunction
#14
REVIEW
Elizabeth A Jennings, Zane H Abi-Rached, Dylan E Jones, Robert O Ryan
The acylcarnitines comprise a wide range of acyl groups linked via an ester bond to the hydroxyl group of L-carnitine. Mass spectrometry methods are capable of measuring the relative abundance of hundreds of acylcarnitines in a single drop of blood. As such, acylcarnitines can serve as sensitive biomarkers of disease. For certain acylcarnitines, however, their biochemical origin, and biomedical significance, remain unclear. One such example is 3-methylglutaryl (3MG) carnitine (C5-3M-DC). Whereas 3MG carnitine levels are normally very low, elevated levels are detected in discrete inborn errors of metabolism (IEM) as well as different forms of heart disease...
November 5, 2023: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/37934979/the-influence-of-some-rare-earth-elements-as-neutron-absorbers-on-the-inception-of-oklo-natural-nuclear-reactors
#15
JOURNAL ARTICLE
Salah-Eddine Bentridi, Benoît Gall, Alexis Nuttin, Hiroshi Hidaka
A totally reflected core model was built to estimate the infinite multiplication factor ${{k}}_{{\infty}}$ as a parametric function using MCNP code. Thus, it was possible to evaluate the influence of a specific physical parameter on the criticality occurrence of the Oklo phenomenon, namely initial Poisons (IP: Gd, Sm and Nd). In fact, these rare earth elements, prior to criticality occurrence in Oklo reaction zones (RZs), are considered as a key parameter in the present study. Thus, it was possible to construct isocritical lines, ${{k}}_{{\infty}}\left({{V}}_{{UO}{2}},{{\varPhi}}_{{C}}\ \right)\cong{1}$, over a significant range of Uraninite volume fraction: ${{V}}_{{UO}{2}}\left[\%\right]{\in}\left[{0};{40}\right]$...
November 2, 2023: Radiation Protection Dosimetry
https://read.qxmd.com/read/37927954/effects-of-prenatal-mobile-phone-radiation-exposure-on-mmp9-expression-implications-for-inflammation-oxidative-stress-and-sensory-motor-impairment-after-neonatal-hypoxia-ischemia-in-rats
#16
JOURNAL ARTICLE
Samira Khayat, Hamed Fanaei, Narges Lakzaee
OBJECTIVE: Non-ionizing radiofrequency radiation, which finds application in various sectors such as industry, commerce, medicine, and particularly in mobile phone technology, has emerged as a topic of significant concern during pregnancy. The aim of this study was to investigate the effect of cell phone radio-frequency (RF) radiation during pregnancy on the Matrix metalloproteinase 2 (MMP-2) and (MMP-9) 9 expressions after neonatal hypoxia-ischemia (HI) in rats. MATERIALS AND METHODS: Two groups were formed by randomly assigning female Wistar rats: Group 1 consisted of female rats that were not exposed to RF radiation during pregnancy, while Group 2 comprised female rats that were exposed to RF radiation during pregnancy...
December 2023: Toxicology Reports
https://read.qxmd.com/read/37663802/astragaloside-iv-protects-lo2-cells-from-oxidative-damage-caused-by-radiation-induced-bystander-effect-through-akt-nrf2-pathway
#17
JOURNAL ARTICLE
Danting Wan, Zihao Zhu, Jie Zhou, Zhengzheng Deng, Pengyuan Lei, Qi Liu, Xiaoya Sun, Bo Huang
BACKGROUND: The protective effects of astragaloside IV (ASIV) on various diseases are well known, but its potential impact on radiation-induced bystander effect (RIBE) has remained unclear. OBJECTIVE: This study aimed to explore the protective mechanism of ASIV against oxidative damage caused by RIBE in LO2 cells. METHODS: To construct the RIBE model, the conditioned medium from HepG2 cells irradiated with radiation was transferred to nonirradiated LO2 cells...
August 2023: Toxicology Research
https://read.qxmd.com/read/37663435/discovery-and-characterization-of-zl-2201-a-potent-highly-selective-and-orally-bioavailable-small-molecule-dna-pk-inhibitor
#18
JOURNAL ARTICLE
Shruti Lal, Neil E Bhola, Bee-Chun Sun, Yuping Chen, Tom Huang, Vivian Morton, Kevin X Chen, Shanghua Xia, Haoyu Zhang, Nehal S Parikh, Qiuping Ye, O Petter Veiby, David I Bellovin, Yuhua Ji
UNLABELLED: DNA-dependent protein kinase (DNA-PK), a driver of the non-homologous end-joining (NHEJ) DNA damage response pathway, plays an instrumental role in repairing double-strand breaks (DSB) induced by DNA-damaging poisons. We evaluate ZL-2201, an orally bioavailable, highly potent, and selective pharmacologic inhibitor of DNA-PK activity, for the treatment of human cancerous malignancies. ZL-2201 demonstrated greater selectivity for DNA-PK and effectively inhibited DNA-PK autophosphorylation in a concentration- and time-dependent manner...
September 2023: Cancer Res Commun
https://read.qxmd.com/read/37561391/multiple-routes-to-color-convergence-in-a-radiation-of-neotropical-poison-frogs
#19
JOURNAL ARTICLE
Evan Twomey, Paulo Melo-Sampaio, Lisa M Schulte, Franky Bossuyt, Jason L Brown, Santiago Castroviejo-Fisher
Convergent evolution is defined as the independent evolution of similar phenotypes in different lineages. Its existence underscores the importance of external selection pressures in evolutionary history, revealing how functionally similar adaptations can evolve in response to persistent ecological challenges through a diversity of evolutionary routes. However, many examples of convergence, particularly among closely related species, involve parallel changes in the same genes or developmental pathways, raising the possibility that homology at deeper mechanistic levels is an important facilitator of phenotypic convergence...
August 10, 2023: Systematic Biology
https://read.qxmd.com/read/37556058/visible-light-driven-zno-fe-3-o-4-magnetic-nanoparticles-for-detoxification-of-diazinon-the-photocatalytic-optimization-process-with-rsm-bbd-model
#20
JOURNAL ARTICLE
Sima Kalantar, Akram Bemani, Mohammad Hossein Sayadi, Elham Chamanehpour
Today, diazinon is one of the most widely used organophosphorus pesticides, whose widespread use can cause many ecological and biological risks. In this research, a magnetic ZnO/Fe3 O4 nanoparticle was used to investigate the photocatalytic degradation of diazinon. Sol-gel synthesis was used to create the nanoparticle, which was then characterized using XRD, FTIR, FESEM, VSM, and XPS techniques. The design of photocatalytic degradation experiments was done using the response surface method and the Box-Behnken design model...
August 9, 2023: Environmental Science and Pollution Research International
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