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https://www.readbyqxmd.com/read/29770247/using-statistical-and-machine-learning-methods-to-evaluate-the-prognostic-accuracy-of-sirs-and-qsofa
#1
Akash Gupta, Tieming Liu, Scott Shepherd, William Paiva
Objectives: The objective of this study was to compare the performance of two popularly used early sepsis diagnostic criteria, systemic inflammatory response syndrome (SIRS) and quick Sepsis-related Organ Failure Assessment (qSOFA), using statistical and machine learning approaches. Methods: This retrospective study examined patient visits in Emergency Department (ED) with sepsis related diagnosis. The outcome was 28-day in-hospital mortality. Using odds ratio (OR) and modeling methods (decision tree [DT], multivariate logistic regression [LR], and naïve Bayes [NB]), the relationships between diagnostic criteria and mortality were examined...
April 2018: Healthcare Informatics Research
https://www.readbyqxmd.com/read/29768299/early-variation-of-quick-sequential-organ-failure-assessment-score-to-predict-in-hospital-mortality-in-emergency-department-patients-with-suspected-infection
#2
Lemachatti Najla, Ortega Mar, Penaloza Andrea, Pierrick Le Borgne, Pierre-Géraud Claret, Céline Occelli, Jennifer Truchot, Florence Dumas, Anne-Laure Feral-Pierssens, Héry Andrianjafy, Sebastien Beaune, Youri Yordanov, Pierre Hausfater, Bruno Riou, Ben Bloom, Evguenia Krastinova, Yonathan Freund
BACKGROUND: The quick sequential organ failure assessment (qSOFA) score showed good prognostic performance in patients with suspicion of infection in the emergency department (ED). However, previous studies only assessed the performance of individual values of qSOFA during the ED stay. As this score may vary over short timeframes, the optimal time of measurement, and the prognostic value of its variation are unclear. The objective of the present study was to prospectively assess the prognostic value of the change in qSOFA over the first 3 h (ΔqSOFA=qSOFA at 3 h-qSOFA at inclusion)...
May 15, 2018: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/29760838/comparing-quick-sequential-organ-failure-assessment-scores-to-end-tidal-carbon-dioxide-as-mortality-predictors-in-prehospital-patients-with-suspected-sepsis
#3
Christopher L Hunter, Salvatore Silvestri, George Ralls, Amanda Stone, Ayanna Walker, Neal Mangalat, Linda Papa
Introduction: Early identification of sepsis significantly improves outcomes, suggesting a role for prehospital screening. An end-tidal carbon dioxide (ETCO2 ) value ≤ 25 mmHg predicts mortality and severe sepsis when used as part of a prehospital screening tool. Recently, the Quick Sequential Organ Failure Assessment (qSOFA) score was also derived as a tool for predicting poor outcomes in potentially septic patients. Methods: We conducted a retrospective cohort study among patients transported by emergency medical services to compare the use of ETCO2 ≤ 25 mmHg with qSOFA score of ≥ 2 as a predictor of mortality or diagnosis of severe sepsis in prehospital patients with suspected sepsis...
May 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29756414/arterial-to-end-tidal-carbon-dioxide-tension-difference-co-2-gap-as-a-prognostic-marker-for-adverse-outcomes-in-emergency-department-patients-presenting-with-suspected-sepsis
#4
Amith Shetty, Sebastian Sparenberg, Kristian Adams, Selwyn Selvedran, Benjamin Tang, Kim Hanna, Jonathan Iredell
OBJECTIVE: The arterial to end-tidal carbon dioxide tension difference (CO2 gap) correlates with physiologic dead space. The prognostic value of increased CO2 gap in trauma and respiratory distress patients is documented. Transpulmonary arteriovenous shunting is identified as a predictor of mortality in non-pulmonary sepsis. We set out to investigate the prognostic value of the CO2 gap in a pilot study of patients with suspected sepsis from non-respiratory causes. METHODS: Patients presenting to tertiary Australian ED with suspected sepsis (n = 215) underwent near-simultaneous end-tidal carbon dioxide and partial pressure of carbon dioxide measurements...
May 13, 2018: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29742628/evaluation-of-dwell-time-for-peripheral-intravenous-catheters-started-in-the-field-for-geriatric-blunt-trauma-patients
#5
Darcy L Day, Francisco Conde
Replacement time for peripheral intravenous (PIV) catheters started in the field is unclear. The purpose of this study was to compare field-start PIV catheter dwell time of 2 days or less versus field-start PIV catheter dwell time of more than 2 days for the development of indicators of infection for geriatric blunt trauma patients. A retrospective case series was conducted at the state-designated trauma referral center. Activated trauma team patients with blunt injury were included if 65 years or older and if admitted from the field for 7 days or more with a PIV catheter placed prehospital...
May 2018: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/29720475/comparison-of-qsofa-with-current-emergency-department-tools-for-screening-of-patients-with-sepsis-for-critical-illness
#6
Robert M Rodriguez, John C Greenwood, Thomas J Nuckton, Bryan Darger, Frances S Shofer, Dawn Troeger, Soo Y Jung, Kelly G Speich, Joel Valencia, J Hope Kilgannon, Danny Fernandez, Brigitte M Baumann
OBJECTIVE: We sought to compare the quick sequential organ failure assessment (qSOFA) to systemic inflammatory response syndrome (SIRS), severe sepsis criteria and lactate levels for their ability to identify ED patients with sepsis with critical illness. METHODS: We conducted this multicenter retrospective cohort study at five US hospitals, enrolling all adult patients admitted to these hospitals from their EDs with infectious disease-related illnesses from 1 January 2016 to 30 April 2016...
May 2, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29715258/comparison-of-sepsis-3-criteria-versus-sirs-criteria-in-screening-patients-for-sepsis-in-the-emergency-department
#7
Brian W Gilbert, Lanae Faires, Amber Meister, Joel Huffman, Rebecca K Faber
The objective of our study was to assess the percentage of patients who met qSOFA criteria, SIRS criteria, both, or none of either criterion and received an International Classification of Diseases, Tenth Revision (ICD-10) code for sepsis after admission from the emergency department (ED). This was a single-center retrospective chart review of medical patients admitted through the ED. Patients were included if they were older than 18 years, were admitted to an inpatient unit through the ED, and received antibiotics within 48 hr of admission...
April 2018: Advanced Emergency Nursing Journal
https://www.readbyqxmd.com/read/29691103/the-risk-stratification-and-prognostic-prediction-value-of-procalcitonin-and-clinical-severity-scores-on-patients-with-community-acquired-pneumonia-in-emergency-department-prediction-value-of-procalcitonin-and-severity-scores-for-cap
#8
Haijiang Zhou, Shubin Guo, Tianfei Lan, Shuai Ma, Fang Zhang, Zhiling Zhao
OBJECTIVE: Community-acquired pneumonia (CAP) is a common presentation to the emergency department (ED) and has high mortality rates. The aim of our study is to investigate the risk stratification and prognostic prediction value of precalcitonin (PCT) and clinical severity scores on patients with CAP in ED. METHODS: 226 consecutive adult patients with CAP admitted in ED of a tertiary teaching hospital were enrolled. Demographic information and clinical parameters including PCT levels were analyzed...
March 21, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29687943/plasma-cell-free-dna-and-qsofa-score-predict-7-day-mortality-in-481-emergency-department-bacteraemia-patients
#9
Juha Rannikko, Tapio Seiskari, Reetta Huttunen, Iina Tarkiainen, Juulia Jylhävä, Mikko Hurme, Jaana Syrjänen, Janne Aittoniemi
BACKGROUND: A few studies have shown that both quick Sequential Organ Failure Assessment (qSOFA) score and cell-free DNA (cfDNA) have potential use as a prognostic marker in patients with infection. We studied these two markers alone and in combination to identify those emergency department (ED) patients with the highest risk of death. METHODS: Plasma cfDNA level was studied on days 0 to 4 after admittance to the ED from 481 culture-positive bloodstream infection cases...
April 24, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29685371/are-qsofa-criteria-better-than-the-systemic-inflammatory-response-syndrome-criteria-for-diagnosing-sepsis-and-predicting-inhospital-mortality
#10
EDITORIAL
Brit Long, Michael D April
No abstract text is available yet for this article.
April 20, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29657373/severe-varicella-pneumonia-in-adults-seven-years-single-center-experience-from-india
#11
Akashdeep Singh, Siddharth Parkash, Sunil K Gupta, R K Soni
Context: Varicella pneumonia is a rare but a serious complication of chickenpox in adults. There is paucity of data on varicella pneumonia from India. Aims: The aim of this study is to describe the clinical manifestations, hospital course, treatment, and outcome of adult patients with severe varicella pneumonia. Settings and Design: This was a retrospective, observational study of patients with severe varicella pneumonia attending a tertiary care teaching hospital...
March 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29650891/-fourteen-cases-of-implanted-central-venous-access-port-related-bloodstream-infection
#12
Toshihiko Sakai, Masakazu Kono, Chie Koumura, Yuri Oyano, Noriko Sakuma, Hirokazu Tojima
We conducted a clinical study involving cases of central venous(CV)port-related infection in Tokyo Rosai Hospital. Fourteen patients with suspected CV port-related infection at Tokyo Rosai Hospital between April 2015 and January 2017 were observed. Identical bacterial types were detected from 2 sets of blood cultures and cultures from the catheter tip, and a definitive diagnosis was made. Data on patient background, causative bacteria, quick sequentialorgan failure assessment (qSOFA)score, CV port placement period, presence or absence of local inflammatory findings, and prognosis were analysed...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29616433/mortality-and-detailed-characteristics-of-pre-icu-qsofa-negative-patients-with-suspected-sepsis-an-observational-study
#13
Izumi Nakayama, Junichi Izawa, Hideyuki Mouri, Tetsuhisa Kitamura, Junji Shiotsuka
BACKGROUND: Recent studies have suggested that quick Sequential Organ Failure Assessment (qSOFA) scores have limited utility in early prognostication in high-mortality populations. The purpose of this study was to investigate the association between pre-ICU qSOFA scores and in-hospital mortality among patients admitted to the ICU with suspected sepsis. This study also aimed to describe detailed clinical characteristics of qSOFA-negative (< 2) patients. METHODS: This single center, observational study, conducted in a Japanese tertiary care teaching hospital between May 2012 and June 2016, enrolled all consecutive adult patients admitted to the ICU with suspected sepsis...
April 3, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29605565/accuracy-of-quick-sequential-organ-failure-assessment-qsofa-score-and-systemic-inflammatory-response-syndrome-sirs-criteria-for-predicting-mortality-in-hospitalized-patients-with-suspected-infection-a-meta-analysis-of-observational-studies
#14
REVIEW
S Maitra, A Som, S Bhattacharjee
OBJECTIVE: To identify sensitivity, specificity and predictive accuracy of quick sequential organ failure assessment (qSOFA) score and systemic inflammatory response syndrome (SIRS) criteria to predict in-hospital mortality in hospitalized patients with suspected infection. METHODS: This meta-analysis followed the Meta-analysis of Observational Studies in Epidemiology (MOOSE) group consensus statement for conducting and reporting the results of systematic review...
March 29, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29576257/mortality-outcomes-based-on-ed-qsofa-score-and-hiv-status-in-a-developing-low-income-country
#15
Adam R Aluisio, Stephanie Garbern, Tess Wiskel, Zeta A Mutabazi, Olivier Umuhire, Chin Chin Ch'ng, Kristina E Rudd, Jeanne D'Arc Nyinawankusi, Jean Claude Byiringiro, Adam C Levine
OBJECTIVE: To evaluate the utility of the quick Sepsis-related Organ Failure Assessment (qSOFA) score to predict risks for emergency department (ED) and hospital mortality among patients in a sub-Saharan Africa (SSA) setting. METHODS: This retrospective cohort study was carried out at a tertiary-care hospital, in Kigali, Rwanda and included patients ≥15years, presenting for ED care during 2013 with an infectious disease (ID). ED and overall hospital mortality were evaluated using multivariable regression, with qSOFA scores as the primary predictor (reference: qSOFA=0), to yield adjusted relative risks (aRR) with 95% confidence intervals (CI)...
March 10, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29563963/addition-of-lactic-acid-levels-improves-the-accuracy-of-quick-sequential-organ-failure-assessment-in-predicting-mortality-in-surgical-patients-with-complicated-intra-abdominal-infections-a-retrospective-study
#16
Yun Tae Jung, Jiyeon Jeon, Jung Yun Park, Myung Jun Kim, Seung Hwan Lee, Jae Gil Lee
Background: The quick sequential organ failure assessment (qSOFA) alone has a poor sensitivity for predicting mortality in patients with complicated intra-abdominal infections, and plasma lactate levels have been shown to have a strong association with mortality in critically ill patients. Therefore, this study aimed to compare the performance of qSOFA with a score derived from a combination of qSOFA and serum lactate levels for predicting mortality in surgical patients with complicated intra-abdominal infections...
2018: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/29544388/complementary-role-of-hypothermia-identification-to-the-quick-sequential-organ-failure-assessment-score-in-predicting-patients-with-sepsis-at-high-risk-of-mortality-a-retrospective-analysis-from-a-multicenter-observational-study
#17
Shigeki Kushimoto, Satoshi Gando, Hiroshi Ogura, Yutaka Umemura, Daizoh Saitoh, Toshihiko Mayumi, Seitaro Fujishima, Toshikazu Abe, Atsushi Shiraishi, Hiroto Ikeda, Joji Kotani, Yasuo Miki, Shin-Ichiro Shiraishi, Koichiro Suzuki, Yasushi Suzuki, Naoshi Takeyama, Kiyotsugu Takuma, Ryosuke Tsuruta, Yoshihiro Yamaguchi, Norio Yamashita, Naoki Aikawa
BACKGROUND: Although the quick Sequential Organ Failure Assessment (qSOFA) has been recommended for identifying patients at higher risk of hospital death, it has only a 60% sensitivity for in-hospital mortality. On the other hand, hypothermia associates with increased mortality and organ failure in patients with sepsis. This study aimed to assess the predictive validity of qSOFA for identifying patients with sepsis at higher risk of multiple organ dysfunction or death and the complementary effect of hypothermia...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29472038/prognostic-performance-of-emergency-severity-index-esi-combined-with-qsofa-score
#18
Hyeongkyu Kwak, Gil Joon Suh, Taegyun Kim, Woon Yong Kwon, Kyung Su Kim, Yoon Sun Jung, Jung-In Ko, So Mi Shin
OBJECTIVE: We conducted this study to investigate whether ESI combined with qSOFA score (ESI+qSOFA) predicts hospital outcome better than ESI alone in the emergency department (ED). METHODS: This was a retrospective study for patients aged over 15years who visited an ED of a tertiary referral hospital from January 1st, 2015 to December 31st, 2015. We calculated and compared predictive performances of ESI alone and ESI+qSOFA for prespecified outcomes. The primary outcome was hospital mortality, and the secondary outcome was composite outcome of in-hospital mortality and ICU admission...
January 31, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29467173/qsofa-sirs-and-news-for-predicting-inhospital-mortality-and-icu-admission-in-emergency-admissions-treated-as-sepsis
#19
Robert Goulden, Marie-Claire Hoyle, Jessie Monis, Darran Railton, Victoria Riley, Paul Martin, Reynaldo Martina, Emmanuel Nsutebu
BACKGROUND: The third international consensus definition for sepsis recommended use of a new prognostic tool, the quick Sequential Organ Failure Assessment (qSOFA), based on its ability to predict inhospital mortality and prolonged intensive care unit (ICU) stay in patients with suspected infection. While several studies have compared the prognostic accuracy of qSOFA to the Systemic Inflammatory Response Syndrome (SIRS) criteria in suspected sepsis, few have compared qSOFA and SIRS to the widely used National Early Warning Score (NEWS)...
February 21, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29465295/predicting-complicated-outcomes-in-spinal-cord-injury-patients-with-urinary-tract-infection-development-and-internal-validation-of-a-risk-model
#20
Sheng Si, Yan Yan, Brian M Fuller, Stephen Y Liang
CONTEXT/OBJECTIVE: Patients with chronic SCI hospitalized for UTI can have significant morbidity. It is unclear whether SIRS criteria, SOFA score, or quick SOFA score can be used to predict complicated outcome. DESIGN: Retrospective cohort study. A risk prediction model was developed and internally validated using bootstrapping methodology. SETTING: Urban, academic hospital in St. Louis, Missouri. PARTICIPANTS: 402 hospitalizations for UTI between October 1, 2010 and September 30, 2015, arising from 164 patients with chronic SCI, were included in the final analysis...
February 21, 2018: Journal of Spinal Cord Medicine
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