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neuroendocrine immunochemistry

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https://www.readbyqxmd.com/read/27353036/mgmt-expression-predicts-response-to-temozolomide-in-pancreatic-neuroendocrine-tumors
#1
J Cros, O Hentic, V Rebours, M Zappa, N Gille, N Theou-Anton, D Vernerey, F Maire, P Lévy, P Bedossa, V Paradis, P Hammel, P Ruszniewski, A Couvelard
Temozolomide (TEM) showed encouraging results in well-differentiated pancreatic neuroendocrine tumors (WDPNETs). Low O(6)-methylguanine-DNA methyltransferase (MGMT) expression and MGMT promoter methylation within tumors correlate with a better outcome under TEM-based chemotherapy in glioblastoma. We aimed to assess whether MGMT expression and MGMT promoter methylation could help predict the efficacy of TEM-based chemotherapy in patients with WDPNET. Consecutive patients with progressive WDPNET and/or liver involvement over 50% who received TEM between 2006 and 2012 were retrospectively studied...
August 2016: Endocrine-related Cancer
https://www.readbyqxmd.com/read/26447992/somatostatin-receptor-sstr-2a-expression-is-a-stronger-predictor-for-survival-than-ki-67-in-pancreatic-neuroendocrine-tumors
#2
Shreya Mehta, Philip R de Reuver, Preetjote Gill, Juliana Andrici, Lisa D'Urso, Anubhav Mittal, Nick Pavlakis, Stephen Clarke, Jaswinder S Samra, Anthony J Gill
Somatostatin receptors (SSTR) are commonly expressed by neuroendocrine tumors. Expression of SSTR-2a and SSTR-5 may impact symptomatic management; however, the impact on survival is unclear. The aim of this study is to correlate SSTR-2a and SSTR-5 expression in pancreatic neuroendocrine tumors (PNETs) with survival. This study is designed to determine the prognostic significance of somatostatin receptors SSTR-2a and SSTR-5 in PNETs. This retrospective cohort study included cases of resected PNETs between 1992 and 2014...
October 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26335532/gly388arg-fgfr4-polymorphism-is-not-predictive-of-everolimus-efficacy-in-well-differentiated-digestive-neuroendocrine-tumors
#3
Jerome Cros, Emilie Moati, Jerome Raffenne, Olivia Hentic, Magali Svrcek, Louis de Mestier, Emilie Sbidian, Nathalie Guedj, Pierre Bedossa, Valerie Paradis, Alain Sauvanet, Yves Panis, Philippe Ruszniewski, Anne Couvelard, Pascal Hammel
INTRODUCTION: Preclinical data suggest that the single nucleotide polymorphism substituting a glycine for an arginine in codon 388 of the FGFR4 transmembrane domain may increase the proliferation of xenografted neuroendocrine cell lines and decrease their sensitivity to everolimus by modulating STAT3 signaling and the mTOR pathway. AIM: To evaluate the prognostic and predictive values of this polymorphism on everolimus efficacy in patients treated for digestive neuroendocrine tumor (NET)...
2016: Neuroendocrinology
https://www.readbyqxmd.com/read/25456943/comparison-of-tumor-markers-for-predicting-outcomes-after-resection-of-nonfunctioning-pancreatic-neuroendocrine-tumors
#4
COMPARATIVE STUDY
Jovenel Cherenfant, Mark S Talamonti, Curtis R Hall, Tiffany A Thurow, Mistry K Gage, Susan J Stocker, Brittany Lapin, Edward Wang, Jonathan C Silverstein, Kathy Mangold, Melanie Odeleye, Karen L Kaul, Ihab Lamzabi, Paolo Gattuso, David J Winchester, Robert W Marsh, Kevin K Roggin, David J Bentrem, Marshall S Baker, Richard A Prinz
BACKGROUND: This study compares the predictability of 5 tumor markers for distant metastasis and mortality in pancreatic neuroendocrine tumors (PNETs). METHODS: A total of 128 patients who underwent pancreatectomy for nonfunctioning PNETs between 1998 and 2011 were evaluated. Tumor specimens were stained via immunochemistry for cytoplasmic and nuclear survivin, cytokeratin 19 (CK19), c-KIT, and Ki67. Univariate and multivariate regression analyses and receiver operating characteristics curve were used to evaluate the predictive value of these markers...
December 2014: Surgery
https://www.readbyqxmd.com/read/24755752/-a-case-of-alpha-cell-nesidioblastosis-and-hyperplasia-with-multiple-glucagon-producing-endocrine-cell-tumor-of-the-pancreas
#5
Huapyong Kang, Sewha Kim, Tae Seop Lim, Hye Won Lee, Heun Choi, Chang Moo Kang, Ho Guen Kim, Seungmin Bang
Nesidioblastosis is a term used to describe pathologic overgrowth of pancreatic islet cells. It also means maldistribution of islet cells within the ductules of exocrine pancreas. Generally, nesidioblastosis occurs in beta-cell and causes neonatal hyperinsulinemic hypoglycemia or adult noninsulinoma pancreatogenous hypoglycemia syndrome. Alpha-cell nesidioblastosis and hyperplasia is an extremely rare disorder. It often accompanies glucagon-producing marco- and mircoadenoma without typical glucagonoma syndrome...
April 2014: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/23049637/case-study-of-appendiceal-carcinoid-during-pregnancy
#6
C Poiana, M Carsote, R Trifanescu, D Terzea, A Croitoru
The carcinoid tumor of the appendix is one of the most common tumors of the appendix, but one of the rarest anatomic locations of carcinoids. The prognosis is very good, as most tumors are incidentally discovered during surgery for acute or sub-acute appendicitis. The diagnosis is exceptional when combined with pregnancy. We present such a case of a 27-year-old female patient. An emergency appendectomy was performed, and soon after, pregnancy was confirmed. The patient had a tumor smaller than 1 cm in diameter, at the tip of the appendix...
September 15, 2012: Journal of Medicine and Life
https://www.readbyqxmd.com/read/22726356/beginnings-a-reflection-on-the-history-of-gastrointestinal-endocrinology
#7
REVIEW
Jens F Rehfeld
The gut is the largest endocrine organ in the body. Gut hormones share some characteristics: Their structure groups hormones into families, each of which originate from a single gene. A hormone gene is often expressed in multiple peptides due to tandem genes, alternative splicing or differentiated posttranslational processing. By these mechanisms, more than 100 different hormonally active peptides are produced in the gastrointestinal tract. In addition, gut hormones are widely expressed outside the gut. The different cell types often express different products of the same gene and release the peptides in different ways...
August 10, 2012: Regulatory Peptides
https://www.readbyqxmd.com/read/22508705/neuroendocrine-acth-producing-tumor-of-the-thymus-experience-with-12-patients-over-25-years
#8
Nicola M Neary, Ariel Lopez-Chavez, Brent S Abel, Alison M Boyce, Nicholas Schaub, King Kwong, Constantine A Stratakis, Cesar A Moran, Giuseppe Giaccone, Lynnette K Nieman
CONTEXT: ACTH-producing neuroendocrine tumor (NET) of the thymus is a rare cause of Cushing's syndrome (CS). The literature consists mainly of isolated case reports. PATIENTS: We studied 12 cases (eight males and four females) diagnosed between 1986 and 2010 with CS and thymic NET who underwent surgical resection. MAIN OUTCOME MEASURES: We measured time from onset of CS to diagnosis of thymic NET, tumor size, histological grade, time to recurrence, and survival and performed a meta-analysis of other published cases of CS associated with thymic NET...
July 2012: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/21597772/positron-emission-tomography-utilizing-c-11-5-hydroxytryptophan-plasma-biochemistry-and-neuroendocrine-immunohistochemistry-of-metastatic-renal-cell-carcinoma
#9
J Westlin, M Edgren, H Letocha, M Stridsberg, E Wilander, S Nilsson
The aim of this study was to characterise metastatic renal cell carcinoma in 18 patients with positron emission tomography (PET) utilising C-11-5-hydroxytryptophan, plasma biochemistry and neuroendocrine immunochemistry. Of these 18 patients, ten underwent the PET investigations. The standardised uptake values (SUVs) in hepatic deposits were higher than those in pulmonary lesions, with mean values of 3.15 and 2.35, respectively. The immunohistochemical study included staining of 10/18 surgical tumour specimens with antibodies reactive with chromogranin (Cg), neurone-specific enolase (NSE), and synaptophysin (Sy)...
July 1995: Oncology Reports
https://www.readbyqxmd.com/read/21298650/familial-recurrent-atrial-myxoma-carney-s-complex
#10
REVIEW
A Nagesh Shetty Roy, Michael Radin, Dennis Sarabi, Emanuel Shaoulian
We report on a family of 4 members, all of whom have had multifocal, recurrent atrial myxomas associated with skin pigmentation, melanotic schwannomas, mucocutaneous myxomas, and tumors of the ovary and pituitary, adrenal, and thyroid glands. Immunochemistry of the myxoma cells is positive for calretinin, confirming their neuroendocrine origin. Genetic studies confirmed mutations in the gene coding protein kinase A, regulatory subunit 1-α (PRKAR1α). This is Carney's complex, characterized by multiple, mucocutaneous myxomas; pigmented lesions over the lips, conjunctiva, and genitalia; adenomas of the breast and thyroid; schwannomas; and endocrinal abnormalities including Cushing syndrome and acromegaly...
February 2011: Clinical Cardiology
https://www.readbyqxmd.com/read/19090447/-rare-neuroendocrine-carcinoma-of-the-gall-bladder-coincidental-occurrence-of-an-endometrioid-ovarian-adenocarcinoma
#11
M Petersen, F Meyer, T Kalinski, J Bischoff, U R M Bohr, H Lippert
HISTORY AND CLINICAL FINDINGS: The histological investigation of a surgical specimen (after cholecystectomy) from a 73-year-old woman revealed a poorly differentiated carcinoma with glandular structures and a lymph node metastasis. INVESTIGATIONS: Comparative immunochemistry, done to exclude metastatic growth of the previously demonstrated endometrioid ovarian carcinoma, was (1) negative for CK7 and CA125, positive for CK20, chromogranin A and synaptophysin (gall bladder and lymph node metastasis); (2) positive for CK7 and CA125, negative for CK20, chromogranin A and synaptophysin (ovary)...
January 2009: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/17427218/role-of-fna-cytology-and-immunochemistry-in-the-diagnosis-and-management-of-medullary-thyroid-carcinoma-report-of-six-cases-and-review-of-the-literature
#12
Punam Bhanot, Jack Yang, Vicki J Schnadig, Roberto Logroño
Medullary thyroid carcinoma (MTC) is a rare neuroendocrine thyroid malignancy. This study retrospectively reviewed 10 fine-needle aspiration samples from six MTC patients. Aspirated specimens were from thyroid (3), cervical lymph nodes (5), left lung (1), and anterior chest wall (1). Cytomorphology consisted predominantly of plasmacytoid cells (3 cases), spindle cells (2 cases), and epithelioid cells (1 case). However, all specimens had a mixture of other cell types and "salt and pepper" chromatin. Only one specimen showed Congo-red-positive amyloid...
May 2007: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/17017394/value-of-ck14-and-cd56-immunostaining-in-distinguishing-small-cell-carcinoma-from-squamous-cell-carcinoma-of-the-esophagus
#13
COMPARATIVE STUDY
Gopi Aryal, Motoji Sawabe, Tomio Arai, Yuji Kimula, Morio Koike, Kaiyo Takubo, Maminata Tiwari, Shyami kumar Rauniyar, Hari Govinda Shrestha
Primary small cell carcinoma of esophagus (SCC) is a rare disease but has more aggressive behavior than esophageal squamous cell carcinoma (SQC). The distinction of SCC from SQC is very important therapeutically. Few systematic studies of immunohistochemical analysis to differentiate primary esophageal SCC with concomitant SQC, and adjacent normal esophageal epithelium have been reported. The objective of this study is to know the immunohistochemical markers in distinguishing SCC from SQC of esophagus. We studied 6 cases of primary esophageal SCC histologically and immunohistochemically using 15 different antibodies including a cytokeratin (CK) panel and neuroendocrine markers...
June 2006: Nepal Medical College Journal: NMCJ
https://www.readbyqxmd.com/read/16008957/-the-prognostic-value-of-human-neuroendocrine-clone-on-colorectal-carcinoma
#14
Xiao-dong Yang, Shan Wang, Hui-yan Meng, Ying-jiang Ye, You-zhi Yu, Ke-wei Jiang, Shen Yang, Jun Qu, Wei-gang Fang
OBJECTIVE: To demonstrate the prognostic value of neuroendocrine clone on colorectal carcinoma. METHODS: The immunochemistry methods were used to investigate the percent of neuroendocrine carcinoma in 73 human colorectal carcinoma. Retrospective analysis and follow-up were carried out in all patients. RESULTS: In all 73 cases of colorectal carcinoma, the total percentage of neuroendocrine carcinoma was 17.8%. Neuroendocrine carcinoma included 11 synapse positive, 6 chromogranin positive and 4 both positive...
June 1, 2005: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/12843921/-primary-hepatic-vipoma
#15
Imed Hachicha, Ahleme Zayene, Lilia Mnif Hachicha, Ali Ben Ali, Moncef Mokni, Fathi Derbel, Younes Dahmene, Dominique Henin, Pierre Gressens, Sadok Korbi, Salem Ajmi, Rached Letaief, Ridha Ben Hadj Hamida
Vipoma is a rare neuroendocrine tumor most frequently localized in the pancreas. When it is extrapancreatic, it is most often neurogenic. We report a case of primary extrapancreatic vipoma that is non neurogenic localized in the right liver in a patient with severe diarrhea and hypokaliema. Computed tomography, magnetic resonance imaging, intraoperative tomography and surgical exploration did not show any other extrahepatic primary lesion. The diagnosis was performed by immunochemistry, tumorous cells were positives with anti-VIP antibody...
May 2003: Gastroentérologie Clinique et Biologique
https://www.readbyqxmd.com/read/12441278/-standards-options-and-recommendations-for-the-management-of-patient-with-carcinoma-of-unknown-primary-site
#16
Roland Bugat, Anne Bataillard, Thierry Lesimple, Jean-Jacques Voigt, Stéphane Culine, Alain Lortholary, Yacine Merrouche, Gérard Ganem, Marie-Christine Kaminsky, Sylvie Negrier, Maurice Perol, Céline Laforêt, Pierre Bedossa, Gérard Bertrand, Jean-Michel Coindre, Karim Fizazi
CONTEXT: The "Standards, Options and Recommendations" (SOR) project, started in 1993, is a collaboration between the Federation of French Cancer Centers (FNCLCC), the 20 French Cancer Centers, and specialists from French Public Universities, General Hospitals and Private Clinics. The main objective is the development of clinical practice guidelines to improve the quality of health care and the outcome of cancer patients. The methodology is based on a literature review and critical appraisal by a multidisciplinary group of experts, with feedback from specialists in cancer care delivery...
October 2002: Bulletin du Cancer
https://www.readbyqxmd.com/read/11718210/gut-endocrinomas-carcinoids-and-related-endocrine-variants-of-the-uterine-cervix-an-analysis-of-205-reported-cases
#17
J Soga, M Osaka, Y Yakuwa
This study was carried out statistically to evaluate the present situation of carcinoids and related endocrine variants in the uterine cervix. A total of 205 patients who had been reported on in world-wide literature were divided into two groups; one, as a carcinoid group, consisting of 81 patients with carcinoids, 49 typical and 32 atypical, and the others, as an endocrine carcinoma (ECC) group, including 124 patients with other remaining endocrine carcinomas variously expressed up to date. A statistical comparison in multiple factors was attempted between these two groups...
September 2001: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/11218314/-immunohistochemical-analysis-of-protein-gene-product-9-5-a-new-marker-for-parietal-epithelial-cells-of-bowman-s-capsules-in-anti-glomerular-basement-membrane-gbm-antibody-induced-glomerulonephritis-of-wky-rats
#18
Y Takeda, I Shirato, K Hayashi, J S He, Y Tomino
Protein gene product 9.5(PGP 9.5) is expressed specifically in neuroendocrine cells and considered to be one of the neuroendocrine markers. Recently, we reported that PGP 9.5 is localized in the parietal epithelial cells(PECs) of Bowman's capsules as well as in neural tissues. In the present study, immunohistochemical analysis of PGP 9.5 as a specific marker of the PECs of Bowman's capsules, synaptopodin as a podocyte-specific marker, and ED-1 as a specific marker of monocytes/macrophages was performed in the cellular crescents in anti-GBM antibody induced glomerulonephritis of WKY rats using serial renal sections...
2001: Nihon Jinzo Gakkai Shi
https://www.readbyqxmd.com/read/8631342/antigenic-regions-of-human-chromogranin-a-and-their-topographic-relationships-with-structural-functional-domains
#19
A Corti, R Longhi, A Gasparri, F Chen, M Pelagi, A G Siccardi
Chromogranin A is a protein contained in the secretory granules of many neuroendocrine cells. The linear antigenic sites of human chromogranin A were studied by examining the cross-reaction of polyclonal and monoclonal anti-chromogranin A antibodies with native chromogranin A and with synthetic peptides encompassing most of the chromogranin A sequence. Chromogranin A residues 1-20, 47-67, 107-158, 254-297, 331-375, and 395-419 were found to be poorly or not antigenic, while residues 25-46, 163-210, 231-253, 298-314 and 68-106, 222-230, 315-330, 376-394 were found to contain weak and strong antigenic sites, respectively...
January 15, 1996: European Journal of Biochemistry
https://www.readbyqxmd.com/read/8458276/fine-needle-aspiration-biopsies-of-metastatic-neuroendocrine-tumors-in-liver-use-of-transmission-electron-microscopy-and-protein-a-gold-technique-in-diagnosis
#20
E Ravinsky, G E Quinonez, M S Diocee
Five fine-needle aspiration biopsies of liver were studied to evaluate the use of electron microscopy and protein A gold technique in the diagnosis of metastatic neuroendocrine tumors. All five cases had cytologic features suggestive of neuroendocrine tumors and neurosecretory granules on ultrastructural examination. The aspirates were stained by the immunoperoxidase technique and the postembedding protein A gold technique using the antibody to chromogranin A. Three cases were positive for chromogranin A by both immunoperoxidase and protein A gold techniques...
1993: Diagnostic Cytopathology
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