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Pap smear for cervical cancer in Colombia

Hernán Vargas, Jenny P Sánchez, Mónica L Guerrero, Leider T Ortiz, Dayanne M Rodríguez, Jairo Amaya, Liliana P Diaz, Sandra L Gómez, Carlos Golijow
OBJECTIVES: To estimate the frequency of human papillomavirus (HPV) infection and the genotype distribution of HPV among women with a Pap smear showing atypical squamous cells of undetermined significance (ASC-US) attending the Program for the Detection and Control of Cervical Cancer in Bogotá, Colombia. STUDY DESIGN: Cervical samples from 200 women with an ASC-US Pap smear were analyzed for the presence of HPV DNA and genotype distribution using a commercial molecular technique (Linear Array®; Roche Molecular Systems, USA)...
2016: Acta Cytologica
Angela M Ruiz-Sternberg, Ángela M Pinzón-Rondón
OBJECTIVE: To compare sexual behaviors and risk perception between young women vaccinated for HPV and unvaccinated Colombian women. METHODS: In a cross-sectional design study, 1436 women (231 adolescents, <18 years; 1205 young women, 18-26 years) completed a self-administered questionnaire between May 2011 and March 2012 in Bogotá, Colombia. Data from vaccinated and unvaccinated women were compared by descriptive statistics and multivariate models. RESULTS: Sexual risk behaviors were not associated with vaccination after adjustment for risk perception, age, educational level, and HPV knowledge...
September 2014: International Journal of Gynaecology and Obstetrics
Luz Angela Chocontá-Piraquive, Nelson Alvis-Guzman, Fernando De la Hoz-Restrepo
BACKGROUND: Cervical cancer is one of the top causes of cancer morbidity and mortality in Colombia despite the existence of a national preventive program. Screening coverage with cervical cytology does not explain the lack of success of the program in reducing incidence and mortality rates by cervical cancer. To address this problem an ecological analysis, at department level, was carried out in Colombia to assess the relationship between cervical screening characteristics and cervical cancer mortality rates...
2010: BMC Health Services Research
Carolina Wiesner, Ricardo Cendales, Raúl Murillo, Marion Piñeros, Sandra Tovar
OBJECTIVE: Evaluating the opportunity and access to diagnosis and treatment for females having had an abnormal Pap smear (high-grade epithelial lesion and cervical cancer) in Colombia from June 2005 to June 2006. MATERIALS AND METHODS: This was a retrospective appraisal using a semi-closed survey of females having had an abnormal Pap smear with high squamous intraepithelial lesions or cervical cancer living in four Colombian departments. These areas were conveniently selected according to their different mortality rates...
February 2010: Revista de Salud Pública
Raúl Murillo, Ricardo Cendales, Carolina Wiesner, Marion Piñeros, Sandra Tovar
INTRODUCTION: Despite the implementation of cytological screening since 1991, cervical cancer continuous to be the leading cause of cancer mortality among Colombian women. OBJECTIVES: The effectiveness of cytology-based cervical cancer screening was subjected to review in the context of the Colombian health system. MATERIALS AND METHODS: A case-control study was done. Invasive cervical cancer cases between 25-69 years were recruited and histopathological confirmation was required...
September 2009: Biomédica: Revista del Instituto Nacional de Salud
Sandra Leon, Ricardo Sánchez, Manuel A Patarroyo, Milena Camargo, Adriano Mejia, Mauricio Urquiza, Manuel E Patarroyo
OBJECTIVE: To assess the frequency of HPV-DNA detection, human papillomavirus (HPV) seropositivity, presence of cervical lesions, and its relationship with certain socio-demographic factors in women from Girardot, Colombia from 2006 to 2007. METHODS: Nine hundred fifty-three women attending their regular Pap smear control voluntarily provided cervical cells and blood samples for HPV-DNA analysis and ELISA detection of anti-L1 peptides and virus-like particles (VLPs) antibodies after answering a questionnaire regarding sexual behaviors, number of births, smoking habits, and socio-demographic background...
May 2009: Sexually Transmitted Diseases
Mauricio Urquiza, Ricardo Sánchez, Jairo Amaya, Sandra León, Jenny Acosta, Manuel A Patarroyo, Milena Camargo, Manuel E Patarroyo
A serological test for the detection of human papillomavirus (HPV) infection in females at risk of developing cervical cancer could be based on conserved L1 peptides with low levels of antigenicity specifically recognized by antibodies from patients with cervical lesions infected with high-risk HPV (HR-HPV) types. The aim was to assess the ability of L1 peptides 18283, 18294, and 18301 compared with the ability of virus-like particles (VLPs) to identify these infections in females. A total of 391 HPV-infected female volunteers were interviewed, and peripheral blood and cervical cells were obtained for detection of anti-HPV antibodies and HPV DNA; all of the patients had a Pap smear test; 287 patients were referred for colposcopy or biopsy, according to gynecological criteria...
November 2008: Journal of Clinical Microbiology
R Hanisch, J Gustat, M E Hagensee, A Baena, J E Salazar, M V Castro, A M Gaviria, G I Sánchez
This study evaluated Pap screening and human papillomavirus (HPV) knowledge in a population of Colombian women as a possible contributing factor of low cervical cancer screening success. This is a descriptive, cross-sectional analysis of 454 women who were approached in five different hospitals and clinics throughout Medellín, Colombia. Of them, 449 females agreed to participate and answered a standardized face-to-face questionnaire regarding Pap screening and HPV knowledge. Using logistic regression, predictors of both Pap and HPV knowledge were examined...
September 2008: International Journal of Gynecological Cancer
Miguel A Castro-Jiménez, Paula A Londoño-Cuellar, Lina M Vera-Cala
OBJECTIVES: Determining the prevalence of Pap smear use and identifying the factors associated with Pap test performance. METHODS: A cross-sectional study was carried out on volunteer women recruited from a local programme for detecting cervical cancer in Mogotes, Colombia. Prevalence ratios (PR) were calculated. Papanicolau smear use was the outcome being measured. Information about demographic characteristics, clinical factors, history of cancer in the family, lifestyle factors and using birth control methods was collected...
September 2006: Revista de Salud Pública
Carolina Wiesner-Ceballos, Marcela Vejarano-Velandia, Juan C Caicedo-Mera, Sandra L Tovar-Murillo, Ricardo Cendales-Duarte
OBJECTIVE: A social representation of the Pap smear is given in this article, as are the barriers against it and the motivation for practising it, aimed at adjusting preventative health services in a particular Colombian town. METHODS: A phenomenological, qualitative study was carried out, using focal groups and workshops for validating the results. A theoretical sample was designed to find differences according to age, heatlh system affiliation and dwelling place within the municipality in question...
September 2006: Revista de Salud Pública
Martha Lucía Serrano, Alfredo Romero, Ricardo Cendales, Myriam Sánchez-Gómez, María Mercedes Bravo
INTRODUCTION: Pap smear has limitations as a screening test for cervical cancer. A marker that allows the identification of women who are at risk of developing cervical cancer would be useful for its prevention. A growing number of studies have demonstrated an association between insulin-like growth factors (IGF) serum levels and increased risk for various cancers. Objective. To assess whether circulating IGF-I, IGF-II, or IGF binding protein 3 (IGFBP-3) were associated with cervical cancer and low-grade and high-grade squamous intraepithelial lesions (LSIL and HSIL)...
June 2006: Biomédica: Revista del Instituto Nacional de Salud
Hernando Gaitán Duarte, Jorge A Rubio Romero, Javier Eslava Schmalbach
OBJECTIVES: Cervical cancer is the most common malignancy affecting Colombian women. Pap smear screening is used for its early detection. Early stages of cervical cancer can be expressed by the presence of inflammatory atypia in the Pap smear. The main objective of this study is to evaluate the role of inflammatory atypia in Pap smear as a marker of squamous intraepithelial lesions (SIL), given that it is not clear how to deal with the presence of inflammatory cells in Pap smear. MATERIALS AND METHODS: A cross sectional study was carried out to establish the operative characteristics of the cervical Pap smear in the colposcopy clinic of the Clínica Piloto Profamilia, Bogotá, between January 1999 and December 2003...
September 2004: Revista de Salud Pública
Jennifer S Smith, Cristina Bosetti, Nubia Muñoz, Rolando Herrero, F Xavier Bosch, José Eluf-Neto, Chris J L M Meijer, Adriaan J C Van Den Brule, Silvia Franceschi, Rosanna W Peeling
To determine whether Chlamydia trachomatis infection is consistently associated with an increased risk of invasive cervical carcinoma (ICC) after accounting for the strong effect of human papillomavirus (HPV) infection, a case-control study of 1,238 cases of ICC and 1,100 control women from 7 countries was carried out (hospital-based studies in Thailand, the Philippines, Morocco, Peru, Brazil and population-based studies in Colombia and Spain, all coordinated by the International Agency for Research on Cancer, Lyon, France)...
September 1, 2004: International Journal of Cancer. Journal International du Cancer
S de Sanjosé, F X Bosch, N Muñoz, K Shah
In this chapter we first describe the variation of cervical cancer in relation to social class. Thereafter we examine the causes for the occurrence of socioeconomic differences in invasive cervical cancer, using data from two case-control studies carried out in Colombia and Spain. Cervical cancer is the most common cancer in developing countries and the sixth most common in developed countries. In all areas, it is more frequent among women of low socioeconomic status, it is associated with multiple sexual partners and early age at first sexual intercourse, and both incidence and mortality are reduced by screening...
1997: IARC Scientific Publications
S de Sanjosé, F X Bosch, N Muñoz, L Tafur, M Gili, I Izarzugaza, A Izquierdo, C Navarro, A Vergara, M T Muñoz, N Ascunce, K V Shah
OBJECTIVES: This study examined the causes of socioeconomic differences in invasive cervical cancer in two countries that differ substantially in cervical cancer incidence and economic development. METHODS: Data were derived from two case-control studies carried out in Spain and Colombia; there were 373 case subjects, 387 control subjects, and 425 husbands interviewed with a structured questionnaire. Exfoliated cells were obtained from cervical or penile scrapes and tested for human papillomavirus (HPV) DNA...
November 1996: American Journal of Public Health
L A Brinton, W C Reeves, M M Brenes, R Herrero, R C de Britton, E Gaitan, F Tenorio, M Garcia, W E Rawls
A case-control study of 759 invasive cervical cancer patients and 1430 controls in Panama, Costa Rica, Colombia and Mexico enabled an evaluation of risk in relation to oral contraceptive use. Overall use was associated with a 21% nonsignificant elevation in risk, with some further increases in risk for more extensive durations of use. Although risks were similar for recent and non-recent users (RRs = 1.3 versus 1.2), recent long-term users were at highest risk (RR for 5+ years use = 1.7, 95% Cl 1.1-2.6). Relationships were similar for women with and without a recent Pap smear, arguing against detection bias...
March 1990: International Journal of Epidemiology
R Herrero, L A Brinton, W C Reeves, M M Brenes, R C de Britton, F Tenorio, E Gaitan
In a case-control study conducted in Latin America, the relationship of injectable contraceptive (IC) use to risk of invasive cervical cancer was analyzed while controlling for a variety of other risk factors, including female and spouse sexual behavior and infection with human papillomaviruses (HPV). Thirty-two cases and 82 controls reported ever having used IC. Women reporting use of IC for less than 5 years had an adjusted RR of 0.5 (95% Cl = 0.3-0.9), but users for 5 or more years had an RR of 2.4 (95% Cl = 1...
July 15, 1990: International Journal of Cancer. Journal International du Cancer
R Herrero, L A Brinton, W C Reeves, M M Brenes, R C de Britton, E Gaitan, F Tenorio
The beneficial effect of cervical cytology in reducing the incidence of invasive cervical cancer is well accepted, but many issues regarding specific patterns of screening remain to be resolved, and preventive programmes need to be adapted to regional characteristics. In a case-control study conducted in Latin America, we investigated cytological screening histories of 759 cases of invasive cervical cancer and 1430 controls, with participation rates of 99% and 96%, respectively. Fifty per cent of the cases and 29% of the controls reported never having been screened...
December 1992: International Journal of Epidemiology
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