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Juan Wen, Congli Kang, Jiaan Wang, Xianwei Cui, Qin Hong, Xingyun Wang, Lijun Zhu, Pengfei Xu, Ziyi Fu, Lianghui You, Xing Wang, Chenbo Ji, Xirong Guo
Whether the maternal vitamin D deficiency is associated with infant birth weight is still an argument. Here, we performed a nested case-control study (545 women who subsequently delivered infant with macrosomia and 1090 controls) to evaluate the association of the maternal serum 25-hydroxyvitamin D [25(OH)D] concentrations with risk of macrosomia. We measured the serum 25(OH)D concentrations by enzyme immunoassays. Logistic regression analysis, receiver-operator characteristic curve analysis and graphical nomogram were used for the statistical analyses...
April 18, 2018: Scientific Reports
Anita Zutshi, Jayasree Santhosh, Julie Sheikh, Fareeha Naeem, Ahmed Al-Hamedi, Shahla Khan, Eishthiag Al-Said
Objectives: This study aimed to determine the prevalence of early pregnancy obesity among Omani women and to review maternal antenatal complications, intrapartum and postpartum events and neonatal complications among such women in comparison to women of normal weight. Methods: This retrospective cohort study included 2,652 pregnant Omani women who delivered at the Royal Hospital, Muscat, Oman, between November 2011 and April 2012. The patients' electronic medical records were reviewed for antenatal, intrapartum and postpartum data...
February 2018: Sultan Qaboos University Medical Journal
Hayedeh Hoorsan, Hamid Alavi Majd, Shahla Chaichian, Abolfazl Mehdizadehkashi, Roza Hoorsan, Meisam Akhlaqghdoust, Yousef Moradi
BACKGROUND: Adverse pregnancy outcome are frequent in developing countries. Pregnancy outcomes are influenced by numerous factors. It seems that maternal anthropometric indices are among the most important factors in this era. The aim of this study was to determine any association between maternal anthropometric characteristics and adverse pregnancy outcomes in Iranian women and provide a predictive model by using factors affecting birth weight (BW) via the pathway analysis. METHODS: This study was performed in Alborz province between September 2014 and December 2016...
February 1, 2018: Archives of Iranian Medicine
Monique E De Paepe, Lawrence Young, Julie R Jones, Umadevi Tantravahi
Simpson-Golabi-Behmel syndrome type I (SGBS, OMIM312870), caused by defects of the GPC3 and GPC4 genes on chromosome Xq26, is an X-linked recessive macrosomia/multiple congenital anomaly disorder characterized by somatic overgrowth, coarse facial features, variable congenital anomalies, increased tumor risk, and mild-to-moderate neurodevelopmental anomalies. We report the postmortem findings in 3 second-trimester male siblings with SGBS who displayed ambiguous genitalia (in all 3) and gonadal dysgenesis (ovotestis) (in 1), thus expanding the SGBS spectrum to include these disorders of sex development...
January 1, 2018: Pediatric and Developmental Pathology
Elham Hosseini, Mohsen Janghorbani, Ashraf Aminorroaya
AIMS: To study the incidence, risk factors, and pregnancy outcomes associated with gestational diabetes mellitus (GDM) diagnosed with one-step and two-step screening approaches. METHODS: 1000 pregnant women who were eligible and consented to participate underwent fasting plasma glucose testing at the first prenatal visit (6-14 weeks). The women free from GDM or overt diabetes were screened at 24-28 weeks using the 50-g glucose challenge test (GCT) followed by 100-g, 3-h oral glucose tolerance test (OGTT) (two-step method)...
April 9, 2018: Diabetes Research and Clinical Practice
Xiangxiang Wang, Qingbo Guan, Jiajun Zhao, Feifei Yang, Zhongshang Yuan, Yongchao Yin, Rui Fang, Lingwei Liu, Changting Zuo, Ling Gao
BACKGROUND: Macrosomia is a serious public health problem worldwide due to its increasing prevalence and adverse influences on maternal and neonatal outcomes. Maternal dyslipidemia exerts potential and adverse impacts on pregnant women and newborns. However, the association between maternal serum lipids and the risk of macrosomia has not yet been clearly elucidated. We explored the association between the maternal lipids profile at late gestation and the risk of having macrosomia among women without diabetes mellitus (DM)...
April 11, 2018: Lipids in Health and Disease
Aisling A Geraghty, Alexandra Sexton-Oates, Eileen C O'Brien, Goiuri Alberdi, Peter Fransquet, Richard Saffery, Fionnuala M McAuliffe
The epigenetic profile of the developing fetus is sensitive to environmental influence. Maternal diet has been shown to influence DNA methylation patterns in offspring, but research in humans is limited. We investigated the impact of a low glycaemic index dietary intervention during pregnancy on offspring DNA methylation patterns using a genome-wide methylation approach. Sixty neonates were selected from the ROLO (Randomised cOntrol trial of LOw glycaemic index diet to prevent macrosomia) study: 30 neonates from the low glycaemic index intervention arm and 30 from the control, whose mothers received no specific dietary advice...
April 6, 2018: Nutrients
Alexander M Vaiserman
Increasing evidence suggests that risk for age-related disease and longevity can be programmed early in life. In human populations, convincing evidence has been accumulated indicating that intrauterine growth restriction (IUGR) resulting in low birth weight (<2.5 kg) followed by postnatal catch-up growth is associated with various aspects of metabolic syndrome, type 2 diabetes and cardiovascular disease in adulthood. Fetal macrosomia (birth weight >4.5 kg), by contrast, is associated with high risk of non-diabetic obesity and cancers in later life...
April 4, 2018: Mechanisms of Ageing and Development
Yuko Hagiwara, Junko Kasai, Sayuri Nakanishi, Yusuke Saigusa, Etsuko Miyagi, Shigeru Aoki
AIMS: To investigate whether the broad interpretation of the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria with application to the early pregnancy, which is adopted as the standard in Japan, is appropriate. METHODS: We conducted this investigation by comparing diabetes-related adverse pregnancy outcomes among women treated for gestational diabetes mellitus (GDM) following an early-pregnancy diagnosis (early-onset GDM, n=528) and those treated for GDM following a mid-pregnancy diagnosis, which is the international standard (Mid-term-onset GDM, n=147) RESULTS: Gestational weight gain was significantly lower in the early-onset GDM group (7...
April 2, 2018: Diabetes Research and Clinical Practice
Q Zhang, L L Wang, R H Bai, S N Dang, H Yan
Objective: To understand the effect of interpregnancy interval (IPI) of childbearing aged women on the birth weight of single live birth neonates in Shaanxi province. Methods: A questionnaire survey was conducted among the childbearing aged women selected through multistage stratified random sampling in Shaanxi during 20l0-2013, all the childbearing aged women had definite pregnancy outcomes. The interpregnancy interval of the childbearing aged women and the birth weight of the newborns were used as the independent variables and dependent variables respectively in multiple linear regression model and quantile regression model, and confounding factors were controlled...
March 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Olubukola Ajala, Constance Chik
BACKGROUND AND OBJECTIVE: Gestational diabetes (GDM) occurs more often in women from certain ethnic groups and is also associated with fetal macrosomia. In this study, we investigated the ability of a gestational diabetes screening test (GDS), the 2hour 75gram-Oral Glucose Tolerance Test (OGTT), and glycated hemoglobin (HbA1c) in predicting postpartum dysglycemia and fetal macrosomia in women of Caucasian, Filipino, Chinese and South-Asian descent. METHODS: 848 women diagnosed with carbohydrate intolerance in pregnancy who completed a 2hour 75g- OGTT within 6 months postpartum, were included in the study...
March 30, 2018: Diabetes Research and Clinical Practice
Daphne N Voormolen, J Hans DeVries, Rieneke M E Sanson, Martijn P Heringa, Harold W de Valk, Marjolein Kok, Aren J van Loon, Klaas Hoogenberg, Dick J Bekedam, Teri C B Brouwer, Martina Porath, Ronald J Erdtsieck, Bas NijBijvank, Huib Kip, Olivier W H van der Heijden, Lammy D Elving, Brenda B Hermsen, B J Potter van Loon, Robert J P Rijnders, Henry J Jansen, Josje Langenveld, Bettina M C Akerboom, Rosalie M Kiewiet, Christiana A Naaktgeboren, Ben W J Mol, Arie Franx, Inge M Evers
AIM: Diabetes is associated with a high risk for adverse pregnancy outcomes. Optimal glycaemic control is fundamental and is traditionally monitored with self-measured glucose profiles and periodical HbA1c measurements. We investigated the effectiveness of additional use of retrospective Continuous Glucose Monitoring (CGM) in diabetic pregnancies. MATERIAL AND METHODS: We performed a nation wide multicentre open label randomised controlled trial studying pregnant women with type 1 diabetes, or type 2 diabetes on insulin therapy with gestational age <16 weeks, or insulin treated gestational diabetes with gestational age <30 weeks...
March 30, 2018: Diabetes, Obesity & Metabolism
Aakash Pandita, Shikha Gupta, Girish Gupta, Astha Panghal
The Beckwith-Wiedemann syndrome (BWS) is a rare genetic syndrome. However, this is one of the most common overgrowth syndromes. This is a genetically and clinically heterogeneous syndrome. Here, we report a case of Beckwith-Weidemann syndrome without macrosomia, visceromegaly and hemihyperplasia but having macroglossia, omphalocele and anterior linear ear lobe creases. The diagnosis was confirmed by gene analysis suggestive of imprinting centre 2 (KvDMR1) hypomethylation defect.
March 30, 2018: BMJ Case Reports
Nuris Rodríguez Vargas, Jose Emilio Fernandez-Britto, Tania Paula Martinez Perez, Rolando Martinez Garcia, Cecilia Margarita Castañeda Garcia, Mailin Garriga Reyes, Claudia Cabrera Estrada, Rossana Plana Labrada, Rosa María García Niebla, Fabiola Blanco Aranguren
INTRODUCTION: Obesity (OB), considered as one of the Non-Transmissible Chronic Diseases, has as its fundamental characteristics that of being prevalent at a global level, increasing in number, affecting developed and developing countries, affecting both genders, and all ages and social groups. OBJECTIVE: To identify if high birth weight is a predictive factor (risk factor) for abdominal obesity in children 7 to 11 years old, and its relationship to gender, age and diet...
March 26, 2018: Clínica e Investigación en Arteriosclerosis
R S Jallad, I Shimon, M Fraenkel, V Medvedovsky, A Akirov, F H Duarte, M D Bronstein
OBJECTIVE: To assess the outcome of pregnancies in a large cohort of women with acromegaly. DESIGN AND METHODS: This is a retrospective analysis of 31 pregnancies in 20 acromegalic patients. RESULTS: Twenty-seven pregnancies resulted in healthy offspring and four resulted in abortion. Three patients underwent transsphenoidal surgery during pregnancy. IGF-1 levels remained elevated during pregnancy in four pregnancies and normalized in 23 cases...
March 25, 2018: Clinical Endocrinology
Monika Zbucka-Kretowska, Mariusz Kuzmicki, Beata Telejko, Joanna Goscik, Michal Ciborowski, Danuta Lipinska, Justyna Hryniewicka, Anna Citko, Slawomir Lawicki, Slawomir Wolczynski
OBJECTIVE: We investigated the diagnostic value of first-trimester adipokines and placental markers in predicting macrosomia. METHODS: Out of 328 women recruited during the prenatal diagnosis between 11th and 13th week of pregnancy and subjected to follow up until delivery, we selected 26 women who gave birth to macrosomic babies and 34 women who gave birth to normal weight neonates for the evaluation of first trimester serum levels of pregnancy associated plasma protein-A, free β-human chorionic gonadotropin, placental growth factor (PIGF), and selected adipokines...
March 21, 2018: Journal of Maternal-fetal & Neonatal Medicine
M Migda, M S Migda, B Migda, E Wender-Ozegowska
Metabolic syndrome (MS) and obesity is an important risk factor for fetal complications like excessive fetal growth manifested by large for gestational age (LGA) and macrosomia, which is a consequence of metabolic disturbances present in the first trimester of pregnancy. The aim of this prospective observational study is to analyze the relationship between the first trimester biochemical and anthropometric parameters of fetuses with the incidence of their macrosomia and LGA so to early predict such complications in women with symptoms of MS...
December 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
Jin Yang, Yang Liu, Hongjie Liu, Heming Zheng, Xiaofeng Li, Lin Zhu, Zhe Wang
OBJECTIVE: The study aimed to explore the effects of maternal iodine status and thyroid diseases on adverse pregnancy outcomes. METHODS: A prospective study was conducted on 2347 pregnant women, who provided 2347 urinary samples tested for iodine, 1082 serum samples tested for thyroid function, and 2347 questionnaires about demographic information. Their pregnancy outcomes were recorded and compared between different urinary iodine concentration (UIC) and thyroid function groups...
May 2018: Journal of Trace Elements in Medicine and Biology
Zhiguo Wang, Hai-Bo Fan, Wan-Wei Yang, Xiao-Dong Mao, Shu-Hang Xu, Xiao-Ping Ma, Gui-Ping Wan, Xiao-Ming Yao, Keyang Chen
AIMS/INTRODUCTION: To explore the relationship between plasma iron levels and gestational diabetes mellitus, as well as its impact on macrosomia. MATERIALS AND METHODS: We retrospectively compared ferritin level and other Characteristics between GDM gravidas and no-GDM gravidas. The correlation between the levels of plasma ferritin and glucose, Haemoglobin was explored. Meanwhile, we assessed the risk factors of macrosomia outcome. Furthermore, we explored the relationship between ferritin level and the incidence of macrosomia outcome...
March 14, 2018: Journal of Diabetes Investigation
K A Sudharshana Murthy, Ambarisha Bhandiwada, Shivani L Chandan, Surakshith L Gowda, G Sindhusree
Background: Prevalence of Gestational Diabetes Mellitus in India is increasing. In addition to performing physiological role in fetoplacental unit during pregnancy, cytokines also play pathophysiological role if expressed in abnormal amounts or sites. Objective: To estimate Proinflammatory Cytokines TNF-α, IL-6, IL-8 and anti-oxidants Glutathione Peroxidase (GTX), Superoxide dismutase (SOD), uric acid and Bilirubin levels in GDM and correlate with pregnancy outcome...
January 2018: Indian Journal of Endocrinology and Metabolism
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