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Li Dai, Yue Chen, Wen Sun, Shiliang Liu
OBJECTIVE: To assess whether hypertensive disorders during pregnancy (HDPs) are associated with the subsequent development of end-stage renal disease (ESRD). METHODS: The present study included 1 598 043 women who delivered in Canadian hospitals between April 1993 and March 2003. The baseline information was from the Canadian Institute for Health Information's Discharge Abstract Database. Women with chronic kidney disease, diabetes mellitus, and other specific conditions were excluded...
June 19, 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Justin G Julander, Venkatraman Siddharthan, Albert H Park, Elizabeth Preston, Pranav Mathur, Michael Bertolio, Hong Wang, Katherine Zukor, Arnaud J Van Wettere, Donal G Sinex, John D Morrey
Zika virus (ZIKV) can cause various diseases in offspring after congenital infection. The purpose of this study was to identify disease phenotypes in pups exposed to ZIKV in utero. Female interferon-α/β, -γ receptor knockout mice (AG129) were infected intraperitoneally with ZIKV 7.5 days' post coitus (dpc). Viral RNA, antigen and infectious virus were detected in some, but not all, maternal and fetal tissues at various times during gestation. Fetuses of infected dams had significant intrauterine growth restriction (IUGR), which was more pronounced as females neared parturition...
June 20, 2018: Scientific Reports
K Ferenc, P Pietrzak, M Wierzbicka, P Matyba, E Grzesiuk, Z Gajewski, R Zabielski
Intrauterine growth retardation (IUGR) leads to increased predisposition to metabolic syndrome in adult life but the mechanisms remain obscure. Considering a significant number of functional similarities, IUGR piglets appear to be a good model to study the development of this syndrome in humans. The aim of the present study was to investigate the ultrastructure and proteomic profile of the liver in IUGR pig neonates to discover early markers of predisposition to obesity and insulin resistance. In our study intestine and liver tissue samples were investigated in 7 day old IUGR and normal body weight (NBW) littermate piglets using histometry, mass spectrometry, in-tissue cytometry analysis and confocal microscopy...
April 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
Ahmed M Maged, Ameer Elsherief, Hany Hassan, Doaa Salaheldin, Khaled A Omran, Maged Almohamady, Sherif Dahab, Radwa Fahmy, Ahmed AbdelHak, Amira Y Shoab, Rehab Lotfy, Yossra S Lasheen, Hala Nabil, Sahar M Y Elbaradie
OBJECTIVE: To assess the relation between maternal, fetal and neonatal outcomes and different forms of hypertensive disorders associating pregnancy in women needed intensive care units (ICU) admission. METHODS: A prospective case control study conducted on 1238 women admitted to hypertensive intensive care unit at three university hospitals. They were classified into four groups. Group I included 472 women with severe preeclampsia (PE), Group II included 243 women with eclampsia (E); Group III included 396 women diagnosed with E associated with HELLP syndrome and Group IV included 127 women diagnosed as HELLP syndrome...
June 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
Annalisa Deodati, Josepmaría Argemí, Daniela Germani, Antonella Puglianiello, Anna Alisi, Cristiano De Stefanis, Roberto Ferrero, Valerio Nobili, Tomás Aragón, Stefano Cianfarani
Early life events are associated with the susceptibility to chronic diseases in adult life. Perturbations of endoplasmic reticulum (ER) homeostasis activate the unfolded protein response (UPR), which contributes to the development of metabolic alterations. Our aim was to evaluate liver UPR in an animal model of intrauterine growth restriction (IUGR). A significantly increased expression of X-box binding protein-1 spliced (XBP1s) mRNA (p<0.01), Endoplasmic Reticulum-localized DnaJ homologue (Erdj4) mRNA (p<0...
2018: PloS One
Erin K Zinkhan, Baifeng Yu, Amnon Schlegel
Intrauterine growth restriction (IUGR) and consumption of a high saturated fat diet (HFD) increase the risk of hypercholesterolemia, a leading cause of morbidity and mortality. The mechanism through which the cumulative impact of IUGR and in utero exposure to a maternal HFD increase cholesterol levels remains unknown. Cholesterol 7α hydroxylase (Cyp7a1) initiates catabolism of cholesterol to bile acids for elimination from the body, and is regulated by microRNA-122 (miR-122). We hypothesized that IUGR rats exposed to a maternal HFD would have increased cholesterol and decreased Cyp7a1 protein levels in juvenile rats, findings which would be normalized by administration of a miR-122 inhibitor...
2018: Frontiers in Physiology
Jia Yin Soo, Michael D Wiese, Mary J Berry, I Caroline McMillen, Janna L Morrison
The effects of intrauterine growth restriction (IUGR) extend well into postnatal life. IUGR is associated with an increased risk of adverse health outcomes, which often leads to greater medication usage. Many medications require hepatic metabolism for activation or clearance, but hepatic function may be altered in IUGR fetuses. Using a sheep model of IUGR, we determined the impact of IUGR on hepatic drug metabolism and drug transporter expression, both important mediators of fetal drug exposure, in late gestation and in neonatal life...
June 8, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Hala Mufeed Said, Nesrine Mohamed El-Gharbawi, Sherif Elanwary Abd El Moneim, Ahmed Abdel Hafez
: Antithrombin is a major suppressor of thrombin, factor Xa and blood coagulation. Inherited antithrombin deficiency is rare and is considered among the common causes of inherited thrombophilia. The relationship between antithrombin and IUGR, is questionable. The aim of this study was to trace the relationship between antithrombin deficiency and the intrauterine weight reduction and neonatal morbidity. The study was conducted on 55 full-term neonates (including 25 baby boys and 30 baby girls), all were admitted to Neonatal Intensive Care Unit in Cairo University Hospitals with IUGR; and another 110 healthy full-term neonates as control group...
June 9, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
Katie L Powell, Anthony Carrozzi, Alexandre S Stephens, Vitomir Tasevski, Jonathan M Morris, Anthony W Ashton, Anthony C Dona
INTRODUCTION: Currently there are no clinical screening tests available to identify pregnancies at risk of developing preeclampsia (PET) and/or intrauterine growth restriction (IUGR), both of which are associated with abnormal placentation. Metabolic profiling is now a stable analytical platform used in many laboratories and has successfully been used to identify biomarkers associated with various pathological states. METHODS: We used nuclear magnetic resonance spectroscopy (NMR) to metabolically profile serum samples collected from 143 pregnant women at 26-41 weeks gestation with pregnancy outcomes of PET, IUGR, PET IUGR or small for gestational age (SGA) that were age-matched to normal pre/term pregnancies...
June 2018: Placenta
Baosheng Chen, Mark S Longtine, Joan K Riley, D Michael Nelson
INTRODUCTION: There is a need for prophylaxis to reduce placental-associated intrauterine growth restriction (IUGR). Pomegranate juice (PJ) is replete with phytochemicals having biological effects at non-pharmacological concentrations. We test the hypothesis that exposure of pregnant mice to hypoxia late in gestation induces cellular stress in the placenta, which can be ameliorated by antecedent maternal consumption of PJ. MATERIALS AND METHODS: We exposed pregnant mice to 12% or 21% oxygen, with food ad libitum or restricted, and with consumption of PJ or glucose between 12...
June 2018: Placenta
Aleksandar Jurisic, Zaklina Jurisic, Eleftheria Lefkou, Joaquim Pombo, Guillermina Girardi
The increase in fetal and neonatal morbidity and mortality associated with twin pregnancies correlates with an increased risk of preterm delivery, low birth weight, and intrauterine growth restriction (IUGR). Although the pathogenesis of IUGR is unclear and thus management remains a major challenge, feto-placental blood vessels are compromised, and altered umbilical blood flow is observed. In this pilot observational study we investigated the effects of pravastatin plus l-arginine on umbilical artery (umb art) blood flow...
June 4, 2018: Vascular Pharmacology
Shreeta Chakraborty, Safirul Islam, Sarbani Saha, Rupasri Ain
Intra-Uterine Growth Restriction (IUGR) is a major cause of fetal and neonatal mortality. Understanding the impact of IUGR on utero-placental gene expression is key to developing effective therapy. In this report we elucidated the impact of IUGR on NOSTRIN and its downstream effector gene expression in the utero-placental compartments. We showed here that induction of IUGR by maternal dexamethasone administration in rats led to up-regulation of NOSTRIN transcript and protein in the mesometrial triangle of the uterus (MG) and not in other utero-placental compartments as compared to control...
May 29, 2018: Scientific Reports
Ya Xing, Jimmy Lloyd Holder, Yong Liu, Meizhen Yuan, Qi Sun, Xiaoxing Qu, Linbei Deng, Jia Zhou, Yingjun Yang, Ming Guo, Sau-Wai Cheung, Luming Sun
PURPOSE: Wolf-Hirschhorn syndrome (WHS) is a contiguous gene syndrome due to terminal chromosome 4p deletions. We explored prenatal diagnosis of WHS by ultrasound as well as karyotype and single nucleotide polymorphism array (SNP array) to characterize the structural variants of WHS prenatally. METHODS: Ten prenatal cases of WHS were evaluated for the indication of the invasive testing, the ultrasound features, and cytogenetic and microarray results. RESULTS: Eight cases were diagnosed by karyotyping and SNP array, while two cases were detected only by SNP array...
May 28, 2018: Archives of Gynecology and Obstetrics
S Zullino, T Simoncini
SSRIs are the first choice for the treatment of mood disorders during pregnancy and lactation. Despite the known side effects, the benefits/risks balance suggests their use. Hypertensive disorders of pregnancy (HDP) and Intrauterine growth restriction (IUGR) are the main vascular effects of these drugs, with mechanisms that involves endothelial dysfunction in feto-placental system. These data are supported by animal models, even if preliminary findings are not yet adequately supported by molecular and clinical data...
May 24, 2018: Vascular Pharmacology
Luting Yu, Jin Zhou, Guohui Zhang, Wen Huang, Linguo Pei, Feng Lv, Yuanzhen Zhang, Wei Zhang, Hui Wang
It is known that inhibiting 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) expression in the placenta can cause fetal over-exposure to maternal glucocorticoids and induce intrauterine growth restriction (IUGR); these effects ultimately increase the risk of adult chronic diseases. This study aimed to investigate the molecular mechanism of the prenatal ethanol exposure (PEE)-induced inhibition of placental 11β-HSD2 expression. Pregnant Wistar rats were intragastrically administered ethanol (4 g/kg/d) from gestational days 9 to 20...
May 23, 2018: Toxicology and Applied Pharmacology
Adam B Salmon, Jonathan Dorigatti, Hillary F Huber, Cun Li, Peter W Nathanielsz
Compelling data exist for programming of chronic later-life diseases and longevity by perinatal developmental programming challenges. Understanding mechanisms by which life course health trajectory and longevity are set is fundamental to understanding aging. Appropriate approaches are needed to determine programming effects on cellular function. We have developed a baboon model in which control mothers eat ad libitum while a second group eat 70% of the global diet fed controls, leading to male and female offspring intrauterine growth restriction (IUGR)...
May 25, 2018: GeroScience
Yitian Guo, Hanwen Luo, Yimeng Wu, Jacques Magdalou, Liaobin Chen, Hui Wang
Epidemiological surveys suggest that adult hypercholesterolemia has an intrauterine origin and exhibits gender differences. Our previous study demonstrated that adult rats with intrauterine growth retardation (IUGR) offspring rats induced by prenatal caffeine exposure (PCE) had a higher serum total cholesterol (TCH) level. In this study, we aimed to analyze the influencing factors, underlying mechanism and interactions affecting hypercholesterolemia in adult offspring with caffeine exposure during pregnancy...
May 22, 2018: Reproductive Toxicology
Anisha Manocha, Gayatri Ravikumar, Julian Crasta
BACKGROUND: Intrauterine fetal demise (IUFD) is an unpredictable and challenging obstetric complication. Its etiology is multifactorial with more than 60% attributed to the placental cause. The present study was done with a primary objective of understanding the placental lesions underlying IUFD. METHODS: In this retrospective observational study, IUFD cases (> 22 weeks) between January 2012-September 2015 were collected from pathology database. The clinical details with ultrasound findings were collected from mother's charts...
May 23, 2018: Journal of Maternal-fetal & Neonatal Medicine
Agata Pająk, Barbara Królak-Olejnik, Agnieszka Szafrańska
Refeeding Syndrome (RFS) is a well-known group of symptoms which occur after the introduction of enteral or parenteral nutrition in undernourished patients. Intrauterine growth restriction (IUGR) is the equivalent of postnatal RFS following the beginning of feeding. The aggressive parenteral nutrition of neonates with very low birth weight (VLBW) resulting from the termination of intrauterine transplacental nutrition is a source of biochemical disorders. The aim of this study was to analyze metabolic disorders in preterm infants during the 1st week of life and to determine the hypophosphatemia risk factors in low birth weight neonates receiving parenteral nutrition...
May 21, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Alketa Stefa, Agaristi Lamprokostopoulou, Despina D Briana, Anna Kontogeorgou, Ifigeneia Papageorgiou, Ariadne Malamitsi-Puchner, Ourania Tsitsilonis, Sarantis Gagos, Evangelia Charmandari
OBJECTIVE: Telomeres are specialized nucleoprotein structures located at the ends of chromosomes, which play a crucial role in genomic stability. Telomere shortening has been proposed as a biomarker for the onset of age-related diseases. This study aimed to determine whether restricted or increased intrauterine growth affects leukocyte telomere length (LTL) at birth. MATERIAL AND METHODS: One hundred sixty five (n = 165) full-term neonates participated in the study...
May 20, 2018: Journal of Maternal-fetal & Neonatal Medicine
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