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https://www.readbyqxmd.com/read/29452236/cardiac-and-placental-mitochondrial-characterization-in-a-rabbit-model-of-intrauterine-growth-restriction
#1
M Guitart-Mampel, A Gonzalez-Tendero, S Niñerola, C Morén, M Catalán-Garcia, I González-Casacuberta, D L Juárez-Flores, O Ugarteburu, L Matalonga, M V Cascajo, F Tort, A Cortés, E Tobias, J C Milisenda, J M Grau, F Crispi, E Gratacós, G Garrabou, F Cardellach
BACKGROUND: Intrauterine growth restriction (IUGR) is associated with cardiovascular remodeling persisting into adulthood. Mitochondrial bioenergetics, essential for embryonic development and cardiovascular function, are regulated by nuclear effectors as sirtuins. A rabbit model of IUGR and cardiovascular remodeling was generated, in which heart mitochondrial alterations were observed by microscopic and transcriptomic analysis. We aimed to evaluate if such alterations are translated at a functional mitochondrial level to establish the etiopathology and potential therapeutic targets for this obstetric complication...
February 13, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29447823/exit-ex-utero-intrapartum-treatment-in-a-growth-restricted-fetus-with-tracheal-atresia
#2
S Kyle Gonzales, Steven Goudy, Kara Prickett, Jane Ellis
Congenital high airway obstruction syndrome (CHAOS) encompasses a heterogeneous group of pathologies leading to poor lung development and difficulty oxygenating the newborn after delivery. While previously uniformly fatal, the ex utero intrapartum therapy (EXIT) procedure has provided a method to treat these patients and provide an airway to potentiate survival. We present a patient diagnosed prenatally with CHAOS secondary to tracheal atresia complicated by severe intra-uterine growth restriction (IUGR) who was successfully delivered via an EXIT procedure at 33-weeks...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29447718/no-240-cytomegalovirus-infection-in-pregnancy
#3
Yoav Yinon, Dan Farine, Mark H Yudin
OBJECTIVES: To review the principles of prenatal diagnosis of congenital cytomegalovirus (CMV) infection and to describe the outcomes of the affected pregnancies. OUTCOMES: Effective management of fetal infection following primary and secondary maternal CMV infection during pregnancy. Neonatal signs include intrauterine growth restriction (IUGR), microcephaly, hepatosplenomegaly, petechiae, jaundice, chorioretinitis, thrombocytopenia and anemia, and long-term sequelae consist of sensorineural hearing loss, mental retardation, delay of psychomotor development, and visual impairment...
February 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29413487/maternal-protein-restriction-during-lactation-induces-early-and-lasting-plasma-metabolomic-and-hepatic-lipidomic-signatures-of-the-offspring-in-a-rodent-programming-model
#4
Aurore Martin Agnoux, Angélina El Ghaziri, Thomas Moyon, Anthony Pagniez, Agnès David, Gilles Simard, Patricia Parnet, El Mostafa Qannari, Dominique Darmaun, Jean-Philippe Antignac, Marie-Cécile Alexandre-Gouabau
Perinatal undernutrition affects not only fetal and neonatal growth but also adult health outcome, as suggested by the metabolic imprinting concept. However, the exact mechanisms underlying offspring metabolic adaptations are not yet fully understood. Specifically, it remains unclear whether the gestation or the lactation is the more vulnerable period to modify offspring metabolic flexibility. We investigated in a rodent model of intrauterine growth restriction (IUGR) induced by maternal protein restriction (R) during gestation which time window of maternal undernutrition (gestation, lactation or gestation-lactation) has more impact on the male offspring metabolomics phenotype...
December 10, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29413485/perinatal-supplementation-of-4-phenylbutyrate-and-glutamine-attenuates-endoplasmic-reticulum-stress-and-improves-colonic-epithelial-barrier-function-in-rats-born-with-intrauterine-growth-restriction
#5
Axel Désir-Vigné, Vianney Haure-Mirande, Pierre de Coppet, Dominique Darmaun, Gwenola Le Dréan, Jean-Pierre Segain
Intrauterine growth restriction (IUGR) can affect the structure and function of the intestinal barrier and increase digestive disease risk in adulthood. Using the rat model of maternal dietary protein restriction (8% vs. 20%), we found that the colon of IUGR offspring displayed decreased mRNA expression of epithelial barrier proteins MUC2 and occludin during development. This was associated with increased mRNA expression of endoplasmic reticulum (ER) stress marker XBP1s and increased colonic permeability measured in Ussing chambers...
December 27, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29397052/intrauterine-growth-restriction-combined-with-a-maternal-high-fat-diet-increased-adiposity-and-serum-corticosterone-levels-in-adult-rat-offspring
#6
E K Zinkhan, B Yu, C W Callaway, R A McKnight
Intrauterine growth restriction (IUGR) and fetal exposure to a maternal high-fat diet (HFD) independently increase the risk of developing obesity in adulthood. Excess glucocorticoids increase obesity. We hypothesized that surgically induced IUGR combined with an HFD would increase adiposity and glucocorticoids more than in non-IUGR offspring combined with the same HFD, findings that would persist despite weaning to a regular diet. Non-IUGR (N) and IUGR (I) rat offspring from dams fed either regular rat chow (R) or an HFD (H) were weaned to either a regular rat chow or an HFD...
February 5, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29392826/reduced-angiogenic-factor-expression-in-intrauterine-fetal-growth-restriction-using-semiquantitative-immunohistochemistry-and-digital-image-analysis
#7
Thushari I Alahakoon, Weiyi Zhang, Susan Arbuckle, Kewei Zhang, Vincent Lee
AIM: To localize, quantify and compare angiogenic factors, vascular endothelial growth factor (VEGF), placental growth factor (PlGF), as well as their receptors fms-like tyrosine kinase receptor (Flt-1) and kinase insert domain receptor (KDR) in the placentas of normal pregnancy and complications of preeclampsia (PE), intrauterine fetal growth restriction (IUGR) and PE + IUGR. METHODS: In a prospective cross-sectional case-control study, 30 pregnant women between 24-40 weeks of gestation, were recruited into four clinical groups...
February 1, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29392408/genome-wide-dna-methylation-analysis-in-jejunum-of-sus-scrofa-with-intrauterine-growth-restriction
#8
Yue Hu, Liang Hu, Desheng Gong, Hanlin Lu, Yue Xuan, Ru Wang, De Wu, Daiwen Chen, Keying Zhang, Fei Gao, Lianqiang Che
Intrauterine growth restriction (IUGR) may elicit a series of postnatal body developmental and metabolic diseases due to their impaired growth and development in the mammalian embryo/fetus during pregnancy. In the present study, we hypothesized that IUGR may lead to abnormally regulated DNA methylation in the intestine, causing intestinal dysfunctions. We applied reduced representation bisulfite sequencing (RRBS) technology to study the jejunum tissues from four newborn IUGR piglets and their normal body weight (NBW) littermates...
February 1, 2018: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/29385271/prescriptive-birth-weight-charts-can-improve-the-prediction-of-adverse-outcomes-in-very-preterm-infants-who-are-small-for-gestational-age
#9
Liset Hoftiezer, Renske G Snijders, Chantal W P M Hukkelhoven, Richard A van Lingen, Marije Hogeveen
AIM: We compared three anthropometric charts to determine which provided the best predictions for adverse outcomes in very preterm small for gestational age infants to address a lack of consensus on this subject. METHODS: This was a retrospective cohort study of infants born below 32 weeks, who were admitted to two level three neonatal intensive care units in The Netherlands from 2008-2013. The birth weights of 1,720 infants were classified as SGA using: a conventional, gender-specific birth weight chart, based on births in The Netherlands between 2000-2007, a prescriptive, gender-specific birth weight chart, based on the same data but without risk factors for intrauterine growth restrictions, and a non-gender-specific fetal weight chart derived from American ultrasonographic measurements...
January 31, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29383842/a-new-mutation-in-the-c-terminal-end-of-ttc37-leading-to-a-mild-form-of-syndromic-diarrhea-tricho-hepato-enteric-syndrome-in-seven-patients-from-two-families
#10
Alexandre Fabre, Laetitia-Marie Petit, Lars F Hansen, Anne V Wewer, Clothilde Esteve, Charlène Chaix, Patrice Bourgeois, Catherine Badens, Anders Paerregaard
Syndromic diarrhea/tricho-hepato-enteric syndrome (SD/THE) is a rare congenital enteropathy with seven main clinical features: intractable diarrhea of infancy, hair abnormalities, intrauterine growth restriction (IUGR), facial dysmorphism, immune dysfunction, and liver and skin abnormalities. SD/THE is caused by mutations in TTC37 or SKIV2L, two genes encoding components of the human SKI complex. To date, approximately 50 SD/THE patients have been described with a wide spectrum of mutations, and only one recurrent mutation has been identified in independent families...
January 31, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29377498/intrauterine-growth-restriction-is-not-associated-with-decreased-exercise-capacity-in-adolescents-with-congenital-heart-disease
#11
Andrew D Spearman, Rohit S Loomba, Michael Danduran, Joshua Kovach
OBJECTIVE: Multiple studies demonstrate the association of intrauterine growth restriction (IUGR) with impaired aerobic fitness in adolescents and adults. To our knowledge, there are no studies including individuals with the history of both IUGR and congenital heart disease (CHD). Thus, we sought to evaluate the impact of IUGR on exercise capacity in adolescents with CHD. STUDY DESIGN: We conducted a retrospective chart review of patients <18 years of age who underwent cardiopulmonary exercise testing (CPET) between August 1, 2003 and July 1, 2016...
January 28, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29374502/changes-in-renal-hemodynamics-of-undernourished-fetuses-appear-earlier-than-iugr-evidences
#12
A Barbero, C Porcu, A Spezzigu, S Succu, M Dattena, M Gallus, G Molle, S Naitana, A Gonzalez-Bulnes, F Berlinguer
The present study used a sheep model of intrauterine growth restriction, combining maternal undernutrition and twinning, to determine possible markers of early damage to the fetal kidney. The occurrence of early deviations in fetal hemodynamics which may be indicative of changes in blood perfusion was assessed by Doppler ultrasonography. A total of 24 sheep divided in two groups were fed with the same standard grain-based diet but fulfilling either their daily maintenance requirements for pregnancy (control group; n=12, six singleton and six twin pregnancies) or only the 50% of such quantity (food-restricted group; n=12; four singleton and eight twin pregnancies)...
January 28, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29363367/the-association-between-mullerian-anomalies-and-iugr-a-meta-analysis
#13
Manoochehr Karami, Ensiyeh Jenabi
BACKGROUND: Published literature regarding the association between Mullerian anomalies and intrauterine growth restriction (IUGR) is controversial. To date, no meta-analysis has been performed for assessing the relationship between the Mullerian anomalies and IUGR. Therefore, the aim of this study was to perform a meta-analysis by combining data from relevant studies to assessing the association of between Mullerian anomalies and IUGR. METHODS: A systematic search was conducted in PubMed, Scopus and Web of Science to identify of all studies prior to September 2017...
January 24, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29363057/ameliorative-effects-of-supplemental-folinic-acid-on-lamotrigine-induced-fetal-malformations-in-the-mouse
#14
Y M Abdulrazzaq, M Shafiullah, J Kochyil, R Padmanabhan, S M A Bastaki
Data from our previous work indicate that Lamotrigine (LTG) is teratogenic in the mouse. In the present study, we attempted to determine the possible protective effects of exogenous folate on LTG-induced fetal anomalies in TO mouse. Experiment I entailed administering 4 mg/kg of folinic acid (FA) and (25 mg/kg) of LTG intraperitoneally three times on gestation day (GD) 8 to a group of mice; other groups were a group that received similar volumes of saline, a group that received LTG and Saline, a group that received FA and saline...
January 23, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29348396/a-case-of-umbilical-artery-thrombosis-in-the-third-trimester-of-pregnancy
#15
Fouad Lutfallah, Nina Oufkir, Georges A Markou, Delphine Frimigacci, Christophe Poncelet
BACKGROUND Umbilical artery thrombosis is an extremely rare complication during pregnancy. Umbilical artery thrombosis has a poor prognosis and is associated with increased rates of perinatal morbidity, including intrauterine growth restriction (IUGR), and fetal mortality. CASE REPORT We report a rare case of umbilical artery thrombosis, diagnosed by ultrasound, at 33 weeks gestation in a 30-year-old woman who had previously had an uneventful pregnancy. CONCLUSIONS Umbilical artery thrombosis is a rare complication of pregnancy that is associated with high fetal mortality...
January 19, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29343193/perinatal-sclerostin-concentrations-in-abnormal-fetal-growth-the-impact-of-gestational-diabetes
#16
Despina D Briana, Maria Boutsikou, Antonios Marmarinos, Dimitrios Gourgiotis, Ariadne Malamitsi-Puchner
OBJECTIVE: To prospectively evaluate maternal and cord blood concentrations of sclerostin -an osteocyte-secreted factor, inhibiting osteoblast differentiation and bone formation and associated with adverse metabolism- in pregnancies with normal and abnormal fetal growth. METHODS: Plasma sclerostin concentrations were determined by ELISA in 80 maternal and 80 cord blood samples from asymmetric intrauterine-growth-restricted (IUGR, n = 30), large-for-gestational-age (LGA, n = 30) and appropriate-for-gestational-age (AGA, n = 20) singleton full-term pregnancies...
January 17, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29338497/a-prospective-observational-study-comparing-cardiac-function-of-small-for-gestational-age-with-appropriate-for-gestational-age-babies-using-serial-echocardiographic-studies
#17
Manish Kumar, Santhanam Sridhar, Niranjan Thomas
BACKGROUND: Approximately 30% of babies born in India are low birth weight (LBW) and about 70% of LBW babies are small for gestational age (SGA). Though there are several trials that have evaluated cardiac function of intrauterine growth restricted (IUGR) babies in utero, there is limited data about postnatal cardiac function in SGA babies during early neonatal period. This study was conducted to evaluate the cardiac functions of SGA babies by serial echocardiographic measurements and compare this with appropriate for gestational age (AGA) babies during the early postnatal period...
January 16, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29330920/macronutrient-and-fibre-intake-of-young-spanish-children-with-reference-to-their-in-utero-growth-status-are-they-eating-a-healthy-diet
#18
Rozina Nuruddin, Mireia Urpi-Sarda, Merida Rodriguez-Lopez, Dolores Garcia-Arenas, Eduard Gratacos, Fatima Crispi, Ruthy Acosta-Rojas
AIM: To compare macronutrient and fibre intake by pre-school children born with intra-uterine growth restriction (IUGR) or as appropriate for gestational age (AGA) and to compare their intake with paediatric nutritional recommendations for identification of potential areas of modification during early life. METHODS: A parental 3-day dietary record was obtained for children of age 1-6 years, born at Hospital Clinic, Barcelona, Spain (2002-2007) with IUGR (n = 37) or AGA (n = 53)...
January 13, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29326857/role-of-color-doppler-flowmetry-in-prediction-of-intrauterine-growth-retardation-in-high-risk-pregnancy
#19
Sachin Khanduri, Saakshi Chhabra, Santosh Yadav, Tushar Sabharwal, Mriganki Chaudhary, Tarim Usmani, Aakshit Goyal, Hritik Sharma
OBJECTIVE: To evaluate the usefulness of Color Doppler flowmetry in the prediction of intrauterine growth restriction (IUGR) in high-risk pregnancies. MATERIALS AND METHOD: A total of 62 high-risk pregnant women underwent Color Doppler flowmetric umbilical artery pulsatility index (PI), resistive index (RI) and systolic/diastolic (S/D) ratio, middle cerebral artery PI, RI and S/D ratio, Ductus venosus S-wave/isovolumetric A-wave index (SIA) and vertebral artery RI at 23-27 weeks, 28-32 weeks and 32-36 weeks of their pregnancy...
November 8, 2017: Curēus
https://www.readbyqxmd.com/read/29321064/the-role-of-ace2-angiotensin-1-7-and-mas1-receptor-axis-in-glucocorticoid-induced-intrauterine-growth-restriction
#20
Elham Ghadhanfar, Aseel Alsalem, Shaimaa Al-Kandari, Jumana Naser, Fawzi Babiker, Maie Al-Bader
BACKGROUND: Plasma and urine levels of the potent vasodilator Ang-(1-7) are elevated in mid and late pregnancy and are correlated with elevated placental angiogenesis, fetal blood flow, and rapid fetal growth. We hypothesized that Ang-(1-7), its receptor (Mas1) and the enzymes involved in Ang-(1-7) production (ACE2 and Membrane metallo-endopeptidase; MME) are down regulated in response to glucocorticoid administration contributing to IUGR. METHODS: Pregnant female Sprague-Dawley rats were injected with dexamethasone (DEX; 0...
December 29, 2017: Reproductive Biology and Endocrinology: RB&E
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