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https://www.readbyqxmd.com/read/29674192/predictive-value-of-sflt-1-plgf-sflt-1-plgf-ratio-and-papp-a-for-late-onset-preeclampsia-and-iugr-between-32-and-37-weeks-of-pregnancy
#1
C Birdir, L Droste, L Fox, M Frank, J Fryze, A Enekwe, A Köninger, R Kimmig, B Schmidt, A Gellhaus
OBJECTIVES: The aim of this study was to investigate, whether maternal serum levels of sFlt-1, PlGF and PAPP-A at third trimester of pregnancy are associated with late-onset PE and intrauterine growth retardation (IUGR) after 34 weeks of pregnancy. METHODS: This was a prospective study measuring the maternal serum levels of soluble tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF) and pregnancy-associated plasma protein-A (PAPP-A) at 32-37 weeks of pregnancy: 730 patients were enrolled and 676 had neither intrauterine growth restriction (IUGR) nor preeclampsia (PE) or pregnancy induced hypertension (PIH) throughout the pregnancy...
April 11, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29664552/importance-of-polymorphic-variants-of-tumour-necrosis-factor-%C3%AE-gene-in-the-etiology-of-intrauterine-growth-restriction
#2
Agnieszka Kaluba-Skotarczak, Justyna Magiełda, Anna Romała, Grażyna Kurzawińska, Magdalena Barlik, Krzysztof Drews, Marcin Ożarowski, Tomasz Łoziński, Agnieszka Seremak-Mrozikiewicz
OBJECTIVES: Intrauterine growth restriction (IUGR) is one of the main global causes of increased perinatal mortality and fetal and neonatal morbidity. It remains a key challenge for modern perinatal medicine. Negative effects of IUGR are manifested not only in the perinatal period but also at the later stages of life. Proinflammatory cytokines and their polymorphisms are hypothesized to play an important role in IUGR pathomechanisms. The aim of the study was to determine the role of selected polymorphisms (-238G >A, -308G >A and -376G >A) of tumor necrosis factor alpha (TNF-α) in the etiology of intrauterine growth restriction...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29664498/-hypophosphatemia-in-preterm-infants-a-bimodal-disorder
#3
María Paz Cubillos Celis, Patricia Mena Nannig
New nutritional approaches to treat extreme premature babies have demonstrated relevant eviden ce of metabolic disturbances with early hypophosphatemia, especially in patients with intrauterine growth restriction (IUGR). They have shown late hypophosphatemia, as well, which is characteristic in the metabolic bone disease. A sytematic search of literature describing metabolic disturbances of phosphorus in preterm newborns is presented, related to the use of early parenteral nutrition and also in the context of metabolic bone disease...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29661800/chorionic-somatomammotropin-impacts-early-fetal-growth-and-placental-gene-expression
#4
Kimberly M Jeckel, Alexander C Boyarko, Gerrit Bouma, Quinton Winger, Russ V Anthony
Several developmental windows, including placentation, must be negotiated to establish and maintain pregnancy. Impaired placental function can lead to pre-eclampsia and/or intrauterine growth restriction (IUGR), resulting in increased infant mortality and morbidity. It has been hypothesized that chorionic somatomammotropin (CSH), plays a significant role in fetal development, potentially by modifying maternal and fetal metabolism. Recently, using lentiviral-mediated in vivo RNA interference in sheep, we demonstrated significant reductions in near-term (135 days of gestation; dGA) fetal and placental size, and altered fetal liver gene expression, resulting from CSH deficiency...
April 16, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29626501/birth-weight-predicts-aging-trajectory-a-hypothesis
#5
REVIEW
Alexander M Vaiserman
Increasing evidence suggests that risk for age-related disease and longevity can be programmed early in life. In human populations, convincing evidence has been accumulated indicating that intrauterine growth restriction (IUGR) resulting in low birth weight (<2.5 kg) followed by postnatal catch-up growth is associated with various aspects of metabolic syndrome, type 2 diabetes and cardiovascular disease in adulthood. Fetal macrosomia (birth weight >4.5 kg), by contrast, is associated with high risk of non-diabetic obesity and cancers in later life...
April 4, 2018: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29626273/hyperelastic-mechanical-properties-of-ex-vivo-normal-and-intrauterine-growth-restricted-placenta
#6
Shier Nee Saw, Jess Yi Ru Low, May Han Huang Ong, Yu Wei Poh, Citra Nurfarah Zaini Mattar, Arijit Biswas, Choon Hwai Yap
Intrauterine Growth Restriction (IUGR) is a serious and prevalent pregnancy complication that is due to placental insufficiency and IUGR babies suffer significantly higher risks of mortality and morbidity. Current detection rate for IUGR is generally poor and thus an alternative diagnostic tool is needed to improve the IUGR detection. Elastography, a non-invasive method that measures the tissue stiffness, has been proposed as one such technique. However, to date, we have limited information on the mechanical properties of IUGR placenta...
April 6, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29620597/early-serum-gut-hormone-concentrations-associated-with-time-to-full-enteral-feedings-in-preterm-infants
#7
Kristen H Shanahan, Xinting Yu, Laura G Miller, Steven D Freedman, Camilia R Martin
OBJECTIVES: The primary objective of this study was to evaluate early postnatal serum gut hormone concentrations in preterm infants as predictors of time to full enteral feedings. The secondary objective was to identify infant characteristics and nutritional factors that modulate serum gut hormone concentrations and time to full enteral feedings. METHODS: Sixty-four preterm infants less than 30 weeks of gestation were included in this retrospective cohort study...
April 3, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29615911/epigenetic-regulation-and-its-therapeutic-potential-in-pulmonary-hypertension
#8
REVIEW
Yu Wang, Lingling Yan, Ziming Zhang, Eric Prado, Linchen Fu, Xuefeng Xu, Lizhong Du
Recent advances in epigenetics have made a tremendous impact on our knowledge of biological phenomena and the environmental stressors on complex diseases. Understanding the mechanism of epigenetic reprogramming during the occurrence of pulmonary hypertension (PH) is important for advanced studies and clinical therapy. In this article, we review the discovery of novel epigenetic mechanisms associated with PH including DNA methylation, histone modification, and noncoding RNA interference. In addition, we highlight the role of epigenetic mechanisms in adult PAH resulting from undesirable perinatal environments-Extrauterine growth restriction (EUGR) and Intrauterine growth retardation (IUGR)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29615752/endothelial-indoleamine-2-3-dioxygenase-1-regulates-the-placental-vascular-tone-and-is-deficient-in-intrauterine-growth-restriction-and-pre-eclampsia
#9
Pablo Zardoya-Laguardia, Astrid Blaschitz, Birgit Hirschmugl, Ingrid Lang, Sereina A Herzog, Liudmila Nikitina, Martin Gauster, Martin Häusler, Mila Cervar-Zivkovic, Eva Karpf, Ghassan J Maghzal, Chris P Stanley, Roland Stocker, Christian Wadsack, Saša Frank, Peter Sedlmayr
Indoleamine 2,3-dioxygenase-1 (IDO1) mediates the degradation of L-tryptophan (L-Trp) and is constitutively expressed in the chorionic vascular endothelium of the human placenta with highest levels in the microvasculature. Given that endothelial expression of IDO1 has been shown to regulate vascular tone and blood pressure in mice under the condition of systemic inflammation, we asked whether IDO1 is also involved in the regulation of placental blood flow and if yes, whether this function is potentially impaired in intrauterine growth restriction (IUGR) and pre-eclampsia (PE)...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29606022/associations-between-neural-injury-markers-of-intrauterine-growth-restricted-infants-and-neurodevelopment-at-2-years-of-age
#10
E Mazarico, E Llurba, L Cabero, O Sánchez, A Valls, A Martin-Ancel, D Cardenas, M D Gómez Roig
OBJECTIVES: The aim of this study was to evaluate the relationships between brain injury biomarkers in intrauterine growth-restricted (IUGR) infants (S100B and neuron-specific enolase (NSE)) and neurodevelopment at 2 years of age. METHODS: This prospective case-control study was a cooperative effort among Spanish Maternal and Child Health Network (Retic SAMID) hospitals. At inclusion, biometry for estimated fetal weight and feto-placental Doppler variables were measured for each infant...
March 31, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29595256/effects-of-dietary-l-arginine-and-n-carbamylglutamate-supplementation-on-intestinal-integrity-immune-function-and-oxidative-status-in-intrauterine-growth-retarded-suckling-lambs
#11
Hao Zhang, Li Dong, Mengzhi Wang, Lihuai Yu, Hongrong Wang
This study investigated the effects of dietary L-arginine (Arg) and N-carbamylglutamate (NCG) supplementation on intestinal integrity, immune function and oxidative status in intrauterine growth retarded (IUGR) suckling lambs. A total of 48 newborn Hu lambs of normal birth weight (CON) and IUGR were allocated randomly into four groups of 12 animals each: CON, IUGR, IUGR+1% Arg, or IUGR+0.1% NCG. All lambs were raised for a period of 21 days from 7 to 28 days after birth. The Arg or NCG group exhibited improved (P < 0...
March 29, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29594647/pregnancy-management-and-outcome-in-patients-with-four-different-tetrahydrobiopterin-disorders
#12
O Kuseyri, A Weissbach, N Bruggemann, C Klein, M Giżewska, D Karall, S Scholl-Bürgi, H Romanowska, E Krzywińska-Zdeb, A A Monavari, I Knerr, Z Yapıcı, V Leuzzi, T Opladen
INTRODUCTION: Inborn errors of tetrahydrobiopterin (BH4 ) biosynthesis or recycling are a group of very rare neurometabolic diseases. Following growing awareness and improved availability of drug treatment the number of patients with BH4 disorders reaching adulthood is constantly increasing. Pregnancy care of patients with these disorders is therefore a new challenge for clinicians. METHODS: This retrospective study summarises for the first time clinical and biochemical monitoring data of 16 pregnancies in seven women with different disorders of BH4 metabolism and evaluates treatment regimens before and during pregnancy in relation to the obstetrical outcome and paediatric follow-up...
March 28, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29593130/nonhuman-primate-breath-volatile-organic-compounds-associate-with-developmental-programming-and-cardio-metabolic-status
#13
Andrew C Bishop, Mark Libardoni, Ahsan Choudary, Biswapriya Biswavas Misra, Kenneth Lange, John Bernal, Mark Nijland, Cun Li, Michael Olivier, Peter W Nathanielsz, Laura A Cox
Rodent and nonhuman primate (NHP) studies indicate that developmental programming by reduced perinatal nutrition negatively impacts life course cardio-metabolic health. We have developed a baboon model in which we feed control mothers (CON) ad libitum while nutrient restricted mothers are fed 70% of ad libitum global feed in pregnancy and lactation. Offspring of nutrient restricted mothers are intrauterine growth restricted (IUGR) at term. By 3.5 years IUGR baboons showed signs of insulin resistance, indicating a pre-diabetic phenotype, in contrast to healthy CON offspring...
March 29, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29590672/prenatally-diagnosed-single-umbilical-artery-sua-retrospective-analysis-of-1169-fetuses
#14
Ulrike Friebe-Hoffmann, Andreas Hiltmann, Thomas W P Friedl, Krisztian Lato, Rüdiger Hammer, Wolfgang Janni, Peter Kozlowski
PURPOSE:  The incidence of a fetal single umbilical artery (SUA) is about 0.5 % and has been associated with an increased risk of congenital malformations, fetal aneuploidy and intrauterine growth restriction (IUGR). MATERIALS AND METHODS:  A retrospective analysis of 1169 women with singleton pregnancies diagnosed with fetal SUA between 1997 and 2014 in a specialized practice for prenatal diagnostics has been performed. Data was obtained on maternal and fetal findings as well as pregnancy outcome...
March 28, 2018: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/29590129/humanin-hn-and-glucose-transporter-8-glut8-in-pregnancies-complicated-by-intrauterine-growth-restriction
#15
Carla Janzen, Margarida Y Y Lei, Il Seok D Jeong, Amit Ganguly, Peggy Sullivan, Vladislava Paharkova, Gina Capodanno, Hiromi Nakamura, Alix Perry, Bo-Chul Shin, Kuk-Wha Lee, Sherin U Devaskar
BACKGROUND: Intrauterine growth restriction (IUGR) results from a lack of nutrients transferred to the developing fetus, particularly oxygen and glucose. Increased expression of the cytoprotective mitochondrial peptide, humanin (HN), and the glucose transporter 8, GLUT8, has been reported under conditions of hypoxic stress. However, the presence and cellular localization of HN and GLUT8 in IUGR-related placental pathology remain unexplored. Thus, we undertook this study to investigate placental expression of HN and GLUT8 in IUGR-affected versus normal pregnancies...
2018: PloS One
https://www.readbyqxmd.com/read/29581724/behaviour-of-the-foramen-ovale-flow-in-fetuses-with-intrauterine-growth-restriction
#16
Ângela R L Nader, Paulo Zielinsky, Alexandre Antonio Naujorks, Luiz Henrique S Nicoloso, Antonio Luiz Piccoli Junior, Natássia Miranda Sulis, Luiza Ferreira van der Sand, Victoria de Bittencourt Antunes, Gabriela Dos Santos Marinho, Fernanda Greinert Dos Santos, Natan Pereira Gosmann, Eduardo Becker Júnior, Renato Frajndlich, Tamara Beherens, Marcelo Brandão da Silva, Caroline Barbisan, Stefano Busato, Mauro Lopes, Caroline Klein
Background: Foramen ovale (FO) flow may be altered in IUGR. This study was designed to test this hypothesis. Methods: Forty pregnant women (24-38 weeks) were divided into 3 groups: group I (IUGR), group II (adequate growth and maternal hypertension), and group III (normal controls). Impedance across the FO was assessed by the FO pulsatility index (FOPI): (systolic velocity - presystolic velocity)/mean velocity. Statistical analysis utilized ANOVA, Tukey test, and ROC curves...
2018: Obstetrics and Gynecology International
https://www.readbyqxmd.com/read/29575245/long-term-renal-tubular-damage-in-intrauterine-growth-restricted-rats
#17
Yayoi Murano, Hiromichi Shoji, Taichi Hara, Ikeda Naho, Amane Endo, Naoto Nishizaki, Toshiaki Shimizu
BACKGROUND: Several investigations have shown an association between intrauterine growth restriction (IUGR) and increased risk for renal diseases or hypertension in the later stages of life. However, mainly glomerular dysfunction is reported and limited information is available to link IUGR with renal tubular damage. The aim of this study was to investigate urinary markers of tubular damage in a rat model of IUGR induced by bilateral uterine artery ligation. METHODS: Pregnant Sprague-Dawley rats underwent bilateral uterine artery ligation, and sham surgeries were performed for the control group...
March 25, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29571821/care-of-the-growth-restricted-newborn
#18
REVIEW
Bianca Carducci, Zulfiqar A Bhutta
With the first 1,000 days of life proving to be a critical window of opportunity for physical and cognitive growth and development, an optimal intrauterine environment is vital. If fetus needs are compromised prenatally, there is an increased risk of intrauterine growth restriction (IUGR), and infants being born premature, low birth weight (LBW), or small-for-gestational age (SGA). Specialized care of these high-risk infants is necessary in terms of preconception interventions, resuscitation, thermoregulation, nutritional support and kangaroo mother care...
February 26, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29569955/placental-growth-factor-reverses-decreased-vascular-and-uteroplacental-mmp-2-and-9-and-increased-mmp-1-and-7-and-collagen-i-and-iv-in-hypertensive-pregnancy
#19
Zongli Ren, Ning Cui, Minglin Zhu, Raouf A Khalil
Preeclampsia is a complication of pregnancy manifested as maternal hypertension (HTN-Preg) and fetal growth restriction (IUGR), with unclear mechanism. Placental ischemia increases antiangiogenic soluble fms-like tyrosine-kinase-1 (sFlt-1) relative to angiogenic placental-growth-factor (PlGF); however, the molecular targets are unclear. To test the hypothesis that placental ischemia-induced changes in sFlt-1 and PlGF target vascular and uteroplacental matrix metalloproteinases (MMPs), we tested if raising sFlt-1/PlGF ratio by infusing sFlt-1 (10 µg/kg/day) in pregnant (Preg) rats increases blood pressure (BP) and alters MMPs, and if correcting sFlt-1/PlGF by infusing PlGF (20 µg/kg/day) in Preg rats with reduced uterine perfusion pressure (RUPP) improves BP and reverses the changes in MMPs...
March 23, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29569542/innate-differences-and-colostrum-induced-alterations-of-jejunal-mucosal-proteins-in-piglets-with-intra-uterine-growth-restriction
#20
Xiaoqiu Wang, Yuhua Zhu, Cuiping Feng, Gang Lin, Guoyao Wu, Defa Li, Junjun Wang
Mammalian neonates undergo rapid transitions from a sterile uterine environment with a continuous intravenous supply of nutrients to a microbe-rich environment with intermittent ingesting of colostrum/milk via the gut. Currently, little is known about the colostrum-induced alterations of intestinal mucosal proteins in piglets with intra-uterine growth restriction (IUGR). In this study, we sought to investigate the innate differences and effects of colostrum on alterations in small-intestinal proteomes of IUGR piglets...
April 2018: British Journal of Nutrition
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