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Cancer early detection

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https://www.readbyqxmd.com/read/29166136/the-gamma-aminobutyric-acid-b-receptor-gabab-encephalitis-clinical-manifestations-and-response-to-immunotherapy
#1
Junzhao Cui, Hui Bu, Junying He, Zeyan Zhao, Weixin Han, Ruiping Gao, Xiaoqing Li, Qing Li, Xiaosu Guo, Yueli Zou
PURPOSE: We report 11 patients diagnosed with GABAB receptor (GABABR) antibodies encephalitis in China and aim to analyse the clinical characteristics, laboratory and imaging findings, therapeutic modalities and outcomes. METHODS: Clinical data from patients diagnosed with anti-GABAB receptor encephalitis in the Second Affiliated Hospital of Hebei Medical University from February 2016 to October 2016 January were retrospectively collected and evaluated. RESULTS: Seven of the eleven patients were males, and a mean age at presentation of 63 years (range: 47-79 years)...
November 22, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29165356/fast-detection-of-a-brca2-large-genomic-duplication-by-next-generation-sequencing-as-a-single-procedure-a-case-report
#2
Marcella Nunziato, Flavio Starnone, Barbara Lombardo, Matilde Pensabene, Caterina Condello, Francesco Verdesca, Chiara Carlomagno, Sabino De Placido, Lucio Pastore, Francesco Salvatore, Valeria D'Argenio
The aim of this study was to verify the reliability of a next generation sequencing (NGS)-based method as a strategy to detect all possible BRCA mutations, including large genomic rearrangements. Genomic DNA was obtained from a peripheral blood sample provided by a patient from Southern Italy with early onset breast cancer and a family history of diverse cancers. BRCA molecular analysis was performed by NGS, and sequence data were analyzed using two software packages. Comparative genomic hybridization (CGH) array was used as confirmatory method...
November 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29165064/immunosensors-in-early-cancer-diagnostics-from-individual-to-multiple-biomarker-assays
#3
Lucie Korecka, Karel Vytras, Zuzana Bilkova
Cancer is a widespread disease characterized by high mortality. To improve the survival rate or facilitate effective therapy, accurate and reliable diagnosis at an early stage is needed. For this reason, there is a continuous push to develop sensitive methods which can be used in cancer diagnosis. Current diagnosis relies on the quantification of cancer biomarkers defined as molecules that are measurable in body fluids or tissues and indicate a change in physiological processes with subsequent pathological manifestations...
November 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29164703/clinicopathological-characteristics-of-patients-with-upper-urinary-tract-urothelial-cancer-with-loss-of-immunohistochemical-expression-of-the-dna-mismatch-repair-proteins-in-universal-screening
#4
Shinji Urakami, Naoko Inoshita, Suguru Oka, Yu Miyama, Sachio Nomura, Masami Arai, Kazushige Sakaguchi, Kazuhiro Kurosawa, Toshikazu Okaneya
OBJECTIVES: To assess the detection rate of putative Lynch syndrome-associated upper urinary tract urothelial cancer among all upper urinary tract urothelial cancers and to examine its clinicopathological characteristics. METHODS: A total of 143 patients with upper urinary tract urothelial cancer who had received total nephroureterectomy were immunohistochemically stained for the expression of mismatch repair proteins MLH1, PMS2, MSH2 and MSH6. For all suspected mismatch repair-deficient cases, MMR genetic testing was recommended and clinicopathological features were examined...
November 22, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29164561/study-of-prevalence-and-influencing-factors-of-depression-in-tumor-patients-and-the-therapeutic-effects-of-fluoxetine
#5
J Dai, N Liao, J Shi, J-Q Tao
OBJECTIVE: To observe the depression in patients with malignant tumor and influencing factors of the disease, as well as to investigate the effects of fluoxetine on depressive symptoms in cancer patients and the immune function. PATIENTS AND METHODS: 262 patients with malignant tumors, confirmed by pathological and radiological diagnosis as malignant tumor were randomly divided into 2 groups: the control group with chemotherapy; the treatment group with chemotherapy and 20 mg/d fluoxetine for six weeks...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164360/risk-of-osteoporosis-after-gastrectomy-in-long-term-gastric-cancer-survivors
#6
Seung Hyun Yoo, Jung Ah Lee, Seo Young Kang, Young Sik Kim, Sung Sunwoo, Beom Soo Kim, Jeong-Hwan Yook
INTRODUCTION: Although early detection and successful gastrectomy have improved the survival of patients with gastric cancer, long-term health problems remain troubling. We evaluated the prevalence of osteoporosis and its risk factors in long-term survivors of gastric cancer after gastrectomy. METHODS: We reviewed the medical records of a tertiary hospital between 2007 and 2014 to identify survivors of gastric cancer who had visited our center at around 5 years after gastrectomy...
November 21, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29163821/the-clinical-use-of-circulating-micrornas-as-non-invasive-diagnostic-biomarkers-for-lung-cancers
#7
Yanlong Yang, Zaoxiu Hu, Yongchun Zhou, Guangqiang Zhao, Yujie Lei, Guangjian Li, Shuai Chen, Kai Chen, Zhenghai Shen, Xiao Chen, Peilin Dai, Yunchao Huang
Many studies have investigated the diagnostic role of circulating microRNAs (miRNAs) in patients with lung cancer; however, the results still remain inconclusive. An updated system review and meta-analysis was necessary to give a comprehensive evaluation of diagnostic role of circulating miRNAs in lung cancer. Eligible studies were searched in electronical databases. The sensitivity and specificity were used to plot the summary receiver operator characteristic (SROC) curve and calculate the area under the curve (AUC)...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163790/a-combination-of-circulating-mirnas-for-the-early-detection-of-ovarian-cancer
#8
Akira Yokoi, Yusuke Yoshioka, Akihiro Hirakawa, Yusuke Yamamoto, Mitsuya Ishikawa, Shun-Ichi Ikeda, Tomoyasu Kato, Kaoru Niimi, Hiroaki Kajiyama, Fumitaka Kikkawa, Takahiro Ochiya
Ovarian cancer is the leading cause of gynecologic cancer mortality, due to the difficulty of early detection. Current screening methods lack sufficient accuracy, and it is still challenging to propose a new early detection method that improves patient outcomes with less-invasiveness. Although many studies have suggested the utility of circulating microRNAs in cancer detection, their potential for early detection remains elusive. Here, we develop novel predictive models using a combination of 8 circulating serum miRNAs...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29162845/helicobacter-pylori-targets-mitochondrial-import-and-components-of-mitochondrial-dna-replication-machinery-through-an-alternative-vaca-dependent-and-a-vaca-independent-mechanisms
#9
Laurent Chatre, Julien Fernandes, Valérie Michel, Laurence Fiette, Patrick Avé, Giuseppe Arena, Utkarsh Jain, Rainer Haas, Timothy C Wang, Miria Ricchetti, Eliette Touati
Targeting mitochondria is a powerful strategy for pathogens to subvert cell physiology and establish infection. Helicobacter pylori is a bacterial pathogen associated with gastric cancer development that is known to target mitochondria directly and exclusively through its pro-apoptotic and vacuolating cytotoxin VacA. By in vitro infection of gastric epithelial cells with wild-type and VacA-deficient H. pylori strains, treatment of cells with purified VacA proteins and infection of a mouse model, we show that H...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29162835/a-signal-amplifiable-biochip-quantifies-extracellular-vesicle-associated-rnas-for-early-cancer-detection
#10
Jiaming Hu, Yan Sheng, Kwang Joo Kwak, Junfeng Shi, Bohao Yu, L James Lee
Detection of extracellular vesicle (EV)-associated RNAs with low expression levels in early-stage cancer remains a challenge and is highly valuable. Here, we report a nanoparticle-based biochip that could capture circulating EVs without isolation, brighten encapsulated RNAs, and amplify fluorescence signals in situ in a single step. We confine catalyzed hairpin DNA circuit (CHDC) in cationic lipid-polymer hybrid nanoparticles (LPHNs) that are tethered on a chip. LPHN features a core-shell-corona structure that facilitates the transfer and mixing of CHDC with EV-associated RNAs when forming the LPHN-EV nanocomplex...
November 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/29162134/serum-thymidine-kinase-1-activity-as-a-pharmacodynamic-marker-of-cyclin-dependent-kinase-4-6-inhibition-in-patients-with-early-stage-breast-cancer-receiving-neoadjuvant-palbociclib
#11
Nusayba Bagegni, Shana Thomas, Ning Liu, Jingqin Luo, Jeremy Hoog, Donald W Northfelt, Matthew P Goetz, Andres Forero, Mattias Bergqvist, Jakob Karen, Magnus Neumüller, Edward M Suh, Zhanfang Guo, Kiran Vij, Souzan Sanati, Matthew Ellis, Cynthia X Ma
BACKGROUND: Thymidine kinase 1 (TK1) is a cell cycle-regulated enzyme with peak expression in the S phase during DNA synthesis, and it is an attractive biomarker of cell proliferation. Serum TK1 activity has demonstrated prognostic value in patients with early-stage breast cancer. Because cyclin-dependent kinase 4/6 (CDK4/6) inhibitors prevent G1/S transition, we hypothesized that serum TK1 could be a biomarker for CDK4/6 inhibitors. We examined the drug-induced change in serum TK1 as well as its correlation with change in tumor Ki-67 levels in patients enrolled in the NeoPalAna trial (ClinicalTrials...
November 21, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29162041/does-anthracycline-based-chemotherapy-in-pregnant-women-with-cancer-offer-safe-cardiac-and-neurodevelopmental-outcomes-for-the-developing-fetus
#12
Marialuisa Framarino-Dei-Malatesta, Paolo Sammartino, Angela Napoli
BACKGROUND: Cancer treatment during pregnancy is a growing problem especially now that women delay childbearing. Systemic treatment of these malignancies during pregnancy centers mainly on the anticancer drugs anthracyclines, widely used in treating hematological and breast cancer during pregnancy and sometimes associated with early and late toxicity for the fetus. Owing to concern about their cardiac and neurodevelopmental toxicity more information is needed on which anthracycline to prefer and whether they can safely guarantee a cardiotoxicity-free outcome in the fetus...
November 21, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29161776/awareness-on-cytology-procedure-in-oral-cancer-detection-among-undergraduates-an-institutional-study
#13
Gayathri Ramesh, Rajeev Pathak, Sunita Pathak, Amrita Raj, Amit Kumar, Anuradha Katiyar
Background: The screening and the early detection of the premalignant and malignant lesions are the only means for controlling the oral cancer which is known to be one of the leading causes for mortality worldwide. Oral exfoliative cytology though not a substitute for biopsy can be a powerful tool for its early detection. Dental Surgeons can play a great role in this direction. Aims and Objectives: The present study was undertaken to assess the self-reported knowledge and attitude regarding the early detection of oral cancer and exfoliative cytology among the undergraduates of Rama Dental College, Kanpur...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29161698/a-comparison-of-three-methods-for-the-detection-of-circulating-tumor-cells-in-patients-with-early-and-metastatic-breast-cancer
#14
Eleni Politaki, Sofia Agelaki, Stella Apostolaki, Dora Hatzidaki, Areti Strati, Filippos Koinis, Maria Perraki, Georgia Saloustrou, Giannis Stoupis, Galatea Kallergi, Maria Spiliotaki, Tereza Skaltsi, Evi Lianidou, Vassilis Georgoulias, Dimitrios Mavroudis
BACKGROUND: We directly compared CTC detection rates and prognostic significance, using three different methods in patients with breast cancer (BC). METHODS: Early (n=200) and metastatic (n=164) patients were evaluated before initiating adjuvant or first-line chemotherapy, using the CellSearchTM System, an RT-qPCR for CK-19 mRNA detection and by double immunofluorescence (IF) microscopy using A45-B/B3 and CD45 antibodies. RESULTS: Using the CellSearchTM System, 37% and 16...
November 20, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29161664/sandwich-type-biosensor-for-the-detection-of-%C3%AE-2-3-sialylated-glycans-based-on-fullerene-palladium-platinum-alloy-and-4-mercaptophenylboronic-acid-nanoparticle-hybrids-coupled-with-au-methylene-blue-mal-signal-amplification
#15
Qiqi Yuan, Junlin He, Yazhen Niu, Jun Chen, Yilin Zhao, Yuchan Zhang, Chao Yu
α2,3-sialylated glycans (α2,3-sial-Gs) are one of the significant tumour biomarkers for the early diagnosis of cancer. In this work, a neoteric sandwich-type biosensor was developed for detecting α2,3-sial-Gs using 4-mercaptophenylboronic acid (4-MPBA) to construct a novel molecular recognition system by the coordination of a boron atom of 4-MPBA to the amide group of Neu5Ac in the α2,3-sial-Gs structure. Amino-functionalized fullerene coupled with palladium-platinum bimetallic alloy nanocrystals (n-C60-PdPt) was synthesized to modify the surface of a glassy carbon electrode (GCE) because the n-C60 nanomaterial affords a large surface area for the on-site reduction of bimetallic alloy nanoparticles and an excellent capacity for electron transfer...
November 18, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29161242/cadherin-1-and-cadherin-3-cooperation-determines-the-aggressiveness-of-pancreatic-ductal-adenocarcinoma
#16
Carole Siret, Aurélie Dobric, Anna Martirosyan, Chloé Terciolo, Sébastien Germain, Renaté Bonier, Thassadite Dirami, Nelson Dusetti, Richard Tomasini, Marion Rubis, Stéphane Garcia, Juan Iovanna, Dominique Lombardo, Véronique Rigot, Frédéric André
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is characterised by an extensive tissue invasion and an early formation of metastasis. Alterations in the expression of cadherins have been reported in PDAC. Yet, how these changes contribute to tumour progression is poorly understood. Here, we investigated the relationship between cadherins expression and PDAC development. METHODS: Cadherins expression was assessed by immunostaining in both human and murine tissue specimens...
November 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29160470/actions-of-nurses-in-early-detection-of-breast-cancer
#17
Fabiana Barbosa Barreto Melo, Carla Andréia Vilanova Marques, Anderson da Silva Rosa, Elisabeth Niglio de Figueiredo, Maria Gaby Rivero de Gutiérrez
OBJECTIVE: Identify the actions for early detection of breast cancer performed by nurses from basic health units; compare the compliance of these actions with the recommendations from the Ministry of Health; analyze the availability of documents to check these recommendations and analyze the association of variables "training," "lato sensu training," and "years of activity" of these professionals with the actions performed. METHOD: A cross-sectional study conducted with 133 nurses from 38 basic health units in the Southeast region of the municipality of São Paulo, interviewed with a validated questionnaire...
November 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29159934/ovarian-cancer-early-detection-by-circulating-ca125-in-the-context-of-anti-ca125-autoantibody-levels-results-from-the-epic-cohort
#18
Renée T Fortner, Helena Schock, Charlotte Le Cornet, Anika Hüsing, Allison F Vitonis, Theron S Johnson, Raina N Fichorova, Titilayo Fashemi, Hidemi S Yamamoto, Anne Tjønneland, Louise Hansen, Kim Overvad, Marie-Christine Boutron-Ruault, Marina Kvaskoff, Gianluca Severi, Heiner Boeing, Antonia Trichopoulou, Eleni-Maria Papatesta, Carlo La Vecchia, Domenico Palli, Sabina Sieri, Rosario Tumino, Carlotta Sacerdote, Amalia Mattiello, N Charlotte Onland-Moret, Petra H Peeters, H B As Bueno-de-Mesquita, Elisabete Weiderpass, J Ramón Quirós, Eric J Duell, Maria-Jose Sánchez, Carmen Navarro, Eva Ardanaz, Nerea Larrañaga, Björn Nodin, Karin Jirström, Annika Idahl, Eva Lundin, Kay-Tee Khaw, Ruth C Travis, Marc Gunter, Mattias Johansson, Laure Dossus, Melissa A Merritt, Elio Riboli, Kathryn L Terry, Daniel W Cramer, Rudolf Kaaks
CA125 is the best ovarian cancer early detection marker to date; however, sensitivity is limited and complementary markers are required to improve discrimination between ovarian cancer cases and non-cases. Anti-CA125 autoantibodies are observed in circulation. Our objective was to evaluate whether these antibodies (1) can serve as early detection markers, providing evidence of an immune response to a developing tumor, and (2) modify the discriminatory capacity of CA125 by either masking CA125 levels (resulting in lower discrimination) or acting synergistically to improve discrimination between cases and non-cases...
November 21, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29159787/how-can-an-education-workshop-serve-as-an-intervention-for-american-indian-screening-participation
#19
Linda Burhansstipanov, Lisa Harjo, Judith Salmon Kaur
American Indians (AIs) continue to have elevated cancer incidence and mortality, and most have issues accessing cancer screening services. During 2013-2014, Mayo and its partners created Native Cancer 101 Module 10 "Prevention and Early Cancer Detection" education workshop. A community-based AI organization implemented nine of these workshops during 2014-2015 via diverse venues. Nearly all participants eligible for at least one type of cancer screening participated in a workshop and consented to follow-up within 3 to 6 months to determine if screenings had been completed or scheduled...
November 20, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29159276/linked-color-imaging-lci-a-novel-image-enhanced-endoscopy-technology-emphasizes-the-color-of-early-gastric-cancer
#20
Hiromitsu Kanzaki, Ryuta Takenaka, Yoshiro Kawahara, Daisuke Kawai, Yuka Obayashi, Yuki Baba, Hiroyuki Sakae, Tatsuhiro Gotoda, Yoshiyasu Kono, Ko Miura, Masaya Iwamuro, Seiji Kawano, Takehiro Tanaka, Hiroyuki Okada
Background and study aims:  Linked color imaging (LCI) and blue laser imaging (BLI) are novel image-enhanced endoscopy technologies with strong, unique color enhancement. We investigated the efficacy of LCI and BLI-bright compared to conventional white light imaging (WLI) by measuring the color difference between early gastric cancer lesions and the surrounding mucosa. Patients and methods:  Images of early gastric cancer scheduled for endoscopic submucosal dissection were captured by LCI, BLI-bright, and WLI under the same conditions...
October 2017: Endoscopy International Open
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