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Women hormones

Xuguang Liu, Huanwen Wu, Lianghong Teng, Hui Zhang, Junliang Lu, Zhiyong Liang
Encapsulated papillary carcinoma (EPC) of the breast is typically of low-to-intermediate grade (LTIG) with favorable prognosis. Rarely, high-grade (HG) EPC cases have been documented in recent years. Herein we compared the morphological, immunohistochemical, and clinical features of LTIG EPC to those of HG EPC. Of the 30 EPC patients, 25 were diagnosed as LTIG and five as HG (median age: 60 and 36 years, respectively); 80% of the HG EPCs exhibited predominantly solid architecture with prominent lymphoplasmacytic infiltrates, more crowded and thicker papillae, and greater stratification and irregular arrangement of malignant epithelial cells...
July 13, 2018: Histology and Histopathology
B Umayal, S N Jayakody, N V Chandrasekharan, W S S Wijesundera, C N Wijeyaratne
Context: Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder affecting young women. Kisspeptins are a family of closely related peptides encoded by Kiss1 gene that controls the hypothalamic-pituitary-gonadal axis by binding to its receptor (GPR54) expressed in gonadotropin-releasing hormone (GnRH) neurons and releases GnRH. Since GnRH secretion is deregulated in PCOS, we hypothesized that dysregulated gonadotropin secretion in PCOS is reflected by kisspeptin levels. Aim: We aimed to measure serum kisspeptin levels of subjects with well-characterized PCOS versus controls and explore any correlation between kisspeptin and PCOS-related reproductive and metabolic disturbances...
July 13, 2018: Journal of Postgraduate Medicine
Sheng Li, Zhao-Feng Li, Qian Wu, Xiao-Chuan Guo, Zhen-Hua Xu, Xiao-Bin Li, Rong Chen, Dao-You Zhou, Cong Wang, Quan Duan, Jian Sun, Ding Luo, Min-Ying Li, Jun-Ling Wang, Hui Xie, Li-Hua Xuan, Sheng-Yong Su, Dong-Mian Huang, Zhi-Shun Liu, Wen-Bin Fu
Objective: Up to 62% of perimenopausal women have depression symptoms. However, there is no efficacy treatment. The aim of this study is to compare the clinical efficacy and safety of EA therapy and escitalopram on perimenopause women with mild-moderate depressive symptom. Method: A multicenter, randomized, positive-controlled clinical trial was conducted at 6 hospitals in China. 242 perimenopause women with mild-moderate depressive symptom were recruited and randomly assigned to receive 36 sessions of EA treatment or escitalopram treatment...
2018: BioMed Research International
Yu Min Lee, Hye Won Chung, Kyungah Jeong, Yeon-Ah Sung, Hyejin Lee, Shinhee Ye, Eun-Hee Ha
Background: Anti-Mullerian hormone (AMH) in women is secreted by granulosa cells of antral follicles. AMH appears to be a very stable marker for ovarian function. It may be used to diagnosis cases of premature ovarian failure, polycystic ovary syndrome (PCOS), and ovarian tumors. It has been suggested that cadmium exposure can reduce female fecundity. The purpose of this study was to investigate whether environmental exposure to cadmium was associated with alterations in AMH with regards to age...
2018: Annals of Occupational and Environmental Medicine
Magdalena Pisarska, Jadwiga Dworak, Michał Natkaniec, Piotr Małczak, Krzysztof Przęczek, Michał Wysocki, Piotr Major, Dorota Radkowiak, Andrzej Budzyński, Michał Pędziwiatr
Introduction: Even though laparoscopic adrenalectomy is currently a standard, there are important variations between different centres in short-term treatment results such as length of hospital stay (LOS) or morbidity. Aim: To determine the factors affecting LOS in patients after laparoscopic transperitoneal lateral adrenalectomy (LTA). Material and methods: The study enrolled 453 patients (173 men and 280 women, mean age 57 years) who underwent LTA between 2009 and 2017...
June 2018: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
Bridget A Knight, Beverley M Shields, Xuemei He, Elizabeth N Pearce, Lewis E Braverman, Rachel Sturley, Bijay Vaidya
Background: Iodine is important for thyroid hormone synthesis, and iodine deficiency in pregnancy may impair fetal neurological development. As perchlorate and thiocyanate inhibit sodium-iodide symporter reducing the transport of iodine from circulation into the thyroid follicular cells, environmental exposure to these substances in pregnancy may impair maternal thyroid hormone synthesis. We aimed to explore the impact of perchlorate and thiocyanate exposure on thyroid status in a cohort of pregnant mothers from South West England...
2018: Thyroid Research
Stine G Kristensen, Claus Y Andersen
In current years, ovarian tissue cryopreservation (OTC) and transplantation is gaining ground as a successful method of preserving fertility in young women with primarily cancer diseases, hereby giving them a chance of becoming biological mothers later on. However, OTC preserves more than just the reproductive potential; it restores the ovarian endocrine function and thus the entire female reproductive cycle with natural levels of essential hormones. In a female population with an increased prevalence in the loss of ovarian function due to induced primary ovarian insufficiency (POI) and aging, there is now, a need to develop new treatments and provide new opportunities to utilize the enormous surplus of follicles that most females are born with and overcome major health issues associated with the lack of ovarian hormones...
2018: Frontiers in Endocrinology
Piyush Bansal, Kavita Khoiwal, Neena Malhotra, Vatsla Dadhwal, Aparna Sharma, Dipika Deka
Objective: Treatment with laparoscopic surgery, gonadotropin-releasing hormone analog (GnRHa) therapy, superovulation (SO), and intrauterine insemination (IUI) have individual benefits in improving fertility outcomes in women with endometriosis. The aim of the study was to evaluate the role of GnRHa in improving outcome in women undergoing SO and IUI after surgical correction of mild endometriosis. Materials and Methods: This was a randomized controlled trial conducted in the Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India, over a period of 2 years and 6 months...
June 2018: Eurasian Journal of Medicine
M Giray Ersoz, Serra Arf, Mumin Hocaoglu, Isil Sayman Muslubas, Murat Karacorlu
AIMS: To determine the demographic and morphological characteristics of patients with central serous chorioretinopathy (CSC) and describe risk factors for CSC. METHODS: We retrospectively reviewed medical records of 811 patients with CSC and 816 healthy controls referred from 2002 to 2018. RESULTS: The female/male ratio of patients with CSC was 1/2.7. Mean age of onset was 45.2 years. The peak prevalence for men occurred at 45-49 years. Women had two prevalence peaks, the higher at 55-59 years and the other at 45-49 years...
July 12, 2018: British Journal of Ophthalmology
Apryl E Pooley, Rebecca C Benjamin, Susheela Sreedhar, Andrew L Eagle, Alfred J Robison, Michelle S Mazei-Robison, S Marc Breedlove, Cynthia L Jordan
BACKGROUND: Our previous study revealed that adult female rats respond differently to trauma than adult males, recapitulating sex differences in symptoms of post-traumatic stress disorder (PTSD) exhibited by women and men. Here, we asked two questions: does the female phenotype depend on (1) social housing condition and/or (2) circulating gonadal hormones? METHODS: For the first study, the effects of single prolonged stress (SPS) were compared for females singly or pair-housed...
July 13, 2018: Biology of Sex Differences
Ursula Ravens
Women have a longer QT-interval than men and this difference appears to evolve after puberty suggesting that sex hormones have an influence on cardiac electrophysiology. Sex hormones do in fact regulate cardiac ion channels via genomic and non-genomic pathways. Women are at greater risk for life threatening arrhythmias under conditions that prolong QT interval. In addition women exhibit greater sensitivity to QT interval prolonging drugs. Female sex has also an impact in propensity to cardiovascular disease, including atrial fibrillation...
July 12, 2018: Canadian Journal of Physiology and Pharmacology
Kelly N Sebzda, Andrew V Kuczmarski, Ryan T Pohlig, Shannon L Lennon, David G Edwards, Megan M Wenner
OBJECTIVE: We recently demonstrated endothelin-B receptors (ETBR ) mediate vasodilation in young but not postmenopausal women; it is unclear if this is related to age or a decline in ovarian hormones. The purpose of this study was to test the hypothesis that ETBR responses are modulated by ovarian hormones. METHODS: We measured cutaneous vasodilatory responses in 12 young women (22±1 years, 23±1 kg/m2 ) during the mid-luteal (ML; days 20-25) and early follicular (EF; days 2-5) phases of the menstrual cycle...
July 12, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
Tong Wang, Bing Xue, Hui Shao, Shu-Yu Wang, Li Bai, Cheng-Hong Yin, Huan-Ying Zhao, Yong-Chao Qi, Le-Le Cui, Xin He, Yan-Min Ma
Background: In the current society, infertility related to age has become a social problem. The in vitro fertilization (IVF) success rate in women with poor ovarian response (POR) is very low. Dandelion extract T-1 (DE-T1) is an effective component of the extract from the leaves and stems of Taraxacum officinale, which is one of the medicines used in some patients with POR, but its molecular mechanism remains unclear. Methods: Following IVF, ovarian granulosa cells (GCs) of sixty patients were extracted and divided into normal ovarian response (NOR) and POR groups...
July 20, 2018: Chinese Medical Journal
Bahareh Amirkalali, Masoud Reza Sohrabi, Ali Esrafily, Mahmoud Jalali, Ali Gholami, Payam Hosseinzadeh, Hossein Keyvani, Farzad Shidfar, Farhad Zamani
Background & objectives: Fatty acids may affect the expression of genes, and this process is influenced by sex hormones. Cytokines are involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), so this study was aimed to assess the association of erythrocyte membrane fatty acids with three cytokines and markers of hepatic injury in NAFLD patients and to explore whether these associations were the same in both sexes. Methods: In this cross-sectional study, 62 consecutive patients (32 men and 30 women) with NAFLD during the study period...
April 2018: Indian Journal of Medical Research
Kuniaki Ota, Toshifumi Takahashi, Satoru Shiraishi, Hideki Mizunuma
AIM: Menorrhagia and dysmenorrhea are common symptoms. Uterine adenomyosis is one of the causes of menorrhagia and dysmenorrhea. These symptoms often decrease the quality of life in women. Microwave endometrial ablation (MEA) is a recently developed procedure that enables endometrial ablation. Dienogest has long been used to suppress endometrium development and reduce adenomyosis-related dysmenorrhea. However, some cases could be resistant to dienogest. In this study, we evaluated the efficacy of a combination of MEA and postoperative dienogest in reducing adenomyosis-related dysmenorrhea and menorrhagia...
July 12, 2018: Journal of Obstetrics and Gynaecology Research
Pilar Z Murphy, Maryam Iranikhah, Crystal M Deas, Maisha K Freeman
OBJECTIVE: To review and summarize studies on the changes in bone mineral density (BMD) and fracture risk following discontinuation of teriparatide therapy. DATA SOURCES: A search of PubMed (1966-May 2016) and International Pharmaceutical Abstracts (1970-May 2016) was conducted using the Medical Subject Headings terms teriparatide, osteoporosis, and withholding treatment. Free text searches included drug holiday, discontinuation, and drug discontinuation. STUDY SELECTION AND DATA EXTRACTION: These searches yielded 79 articles...
July 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
P Yi, H L Niu, Q Gao, F H Wang, W Jia, Z R Chen, J Q Xia, L P Li, Y Cao, R X Zeng
Objective: To investigate the pathologic features of gonadal tissues of disorders of sexual development (DSD) in children. Methods: Fifty-three cases of gonadal developmental disorders were collected from July 2015 to August 2017 at Guangzhou Women and Children's Medical Center. Clinical manifestations, karyotypes, sex hormone levels, ultrasound imaging, histology and immunophenotype of gonadal tissues were analyzed. Results: The age of patients ranged from 7 months to 17 years with an average of (50.7 ± 47...
July 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Valerie A Flores, Nina S Stachenfeld, Hugh S Taylor
BACKGROUND: Endometriosis is a gynecologic disorder affecting 6-10% of reproductive-aged women. First-line therapies are progestin-based regimens; however, failure rates are high, often requiring alternative hormonal agents, each with unfavorable side effects. Bazedoxifene with conjugated estrogens is approved for treatment of menopausal symptoms, and use in animal studies has demonstrated regression of endometriotic lesions. As such, it represents a potential treatment option for endometriosis...
July 10, 2018: Obstetrics and Gynecology
James M Weinberger, Justin Houman, Ashley T Caron, Devin N Patel, Avi S Baskin, A Lenore Ackerman, Karyn S Eilber, Jennifer T Anger
OBJECTIVE: To quantify the placebo effect of various pharmacologic modalities including neuromodulators, hormonal agents, and onabotulinum toxin A for female sexual dysfunction. DATA SOURCES: Using Meta-analyses Of Observational Studies in Epidemiology guidelines, we conducted a systematic review of PubMed, EMBASE,, and the Cochrane Review databases. METHODS OF STUDY SELECTION: Eleven search terms, "female sexual dysfunction" "treatment" in combination with "hypoactive sexual desire," "arousal disorder," "sexual pain disorder," "genitourinary syndrome of menopause," "orgasmic disorder," "vulvovaginal atrophy," "vaginismus," "vaginal atrophy," "vulvodynia," and "vestibulitis," were used...
July 10, 2018: Obstetrics and Gynecology
Ricardo Azziz
Polycystic ovary syndrome (PCOS) is a highly prevalent disorder, representing the single most common endocrine-metabolic disorder in reproductive-aged women. Currently there are four recognized phenotypes of PCOS: 1) hyperandrogenism+oligo-anovulation+polycystic ovarian morphology; 2) hyperandrogenism+oligo-anovulation; 3) hyperandrogenism+polycystic ovarian morphology; and 4) oligo-anovulation+polycystic ovarian morphology, each with different long-term health and metabolic implications. Clinicians should clearly denote a patient's phenotype when making the diagnosis of PCOS...
July 10, 2018: Obstetrics and Gynecology
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