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Women hormones

Ana Paula França, Maria de Fátima Nunes Marucci, Maria de Lourdes do Nascimento da Silva, Manuela de Almeida Roediger
To verify the association between obesity and demographic, clinical and lifestyle variables in climacteric women, a cross-sectional study was conducted in outpatient clinics, with 469 women aged 40 to 65 years in the city of São Paulo, Brazil. The dependent variables were: obesity according to body mass index (BMI) and obesity according to percentage of body fat (% BF). The main explanatory variable was: climacteric phase (pre or postmenopausal); and control variables were: age; years of formal study; parity; menopausal hormone therapy (MHT) use; physical activity practice and smoking habit...
November 2018: Ciência & Saúde Coletiva
Chisato Nagata, Kie Konishi, Keiko Wada, Takashi Tamura, Yuko Goto, Sachi Koda, Fumi Mizuta, Shinichi Iwasa
Exposure to acrylamide during pregnancy may disturb pregnancy hormones and the growth of the fetus. The present study aimed to examine the association of maternal acrylamide intake with maternal and cord sex hormone levels during pregnancy and at birth and birth size of offspring. The study subjects were 204 pregnant Japanese women and their newborn girls. Intake of acrylamide was assessed based on 5-day diet records at approximately the 29th week of pregnancy. The concentrations of estradiol, estriol, and testosterone were measured in maternal serum at the 29th weeks of pregnancy and at delivery and umbilical cord blood at delivery...
November 14, 2018: Nutrition and Cancer
Leszek Teresiński, Olimpia Sipak, Aleksandra Rył, Marek Masiuk, Iwona Rotter, Weronika Ratajczak, Malwina Łazowska, Maria Słomczyńska, Mariola Marchlewicz, Beata Karakiewicz, Maria Laszczyńska
INTRODUCTION: The morphology of the endometrium constantly changes in the reproductive period, depending on the levels of ovarian steroid hormones, and undergoes atrophic changes during menopause as a result of their insufficiency. The purpose of this study was to analyze morphological and morphometric changes in the mucous and muscle layers of the uterine wall in postmenopausal women, and to assess localization and number of cells showing the expression of steroid hormone receptors, namely estrogen receptor α (ER-α), progesterone receptor (PR), and androgen receptor (AR) in glandular epithelial cells and smooth muscle cells in particular groups of women...
November 14, 2018: Histology and Histopathology
Satomi Minato, Naoki Sakane, Kazuhiko Kotani, Shinsuke Nirengi, Ikuyo Hayashi, Akiko Suganuma, Ken Yamaguchi, Kenji Takakura, Narumi Nagai
Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among reproductive-aged women. While PCOS is associated with an increased risk of obesity and insulin resistance, little is known regarding the prevalence of and risk factors for nonalcoholic fatty liver disease (NAFLD) among Japanese women with PCOS. We estimated the prevalence of and risk factors for elevated liver enzymes, as the index of NAFLD, in Japanese women with PCOS. Methods: We retrospectively reviewed 102 reproductive-aged women who visited the Department of Gynecology, Kyoto Medical Center in Japan from January 2000 to September 2016...
December 2018: Journal of Clinical Medicine Research
M Lambert, E Begon, C Hocké
INTRODUCTION: Choosing contraception for women over 40 can be sometimes difficult but it is crucial since fertility and pregnancy's risks still exist. It requires a thorough evaluation of the situation, in order to identify any vascular and metabolic risk factors, along with the uterine and mammary benign pathologies already diagnosed. OBJECTIVE: The objective of this review was to elaborate some guidelines for clinical practice regarding contraception's prescription for women over 40...
November 10, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
Cody Ramin, Betty J May, Richard B S Roden, Mikiaila M Orellana, Brenna C Hogan, Michelle S McCullough, Dana Petry, Deborah K Armstrong, Kala Visvanathan
BACKGROUND: Osteoporosis, an indicator of significant bone loss, has been consistently reported among older breast cancer survivors. Data are limited on the incidence of osteopenia, an earlier indicator of bone loss, and osteoporosis in younger breast cancer survivors compared with cancer-free women. METHODS: We prospectively examined bone loss in 211 breast cancer survivors (mean age at breast cancer diagnosis = 47 years) compared with 567 cancer-free women in the same cohort with familial risk for breast cancer...
November 13, 2018: Breast Cancer Research: BCR
Shinichi Komiyama, Masaru Nagashima, Tomoko Taniguchi, Yuki Yokouchi, Tsuyoki Kugimiya
Ovarian endometriotic cysts have been identified as the possible origin of ovarian clear cell carcinoma (OCCC), so predicting or preventing future transformation is important. Early detection of clear cell carcinoma is important because it shows low sensitivity to chemotherapy and the prognosis is worse than for other histologic types. We recently treated 2 patients with OCCC. They were both young women with no family history of cancer who received long-term oral contraceptive therapy for endometriotic cysts, and the histologic diagnosis was typical clear cell carcinoma in both patients...
November 13, 2018: Gynecologic and Obstetric Investigation
Amy G Bryant, Anne Drapkin Lyerly, Stephanie DeVane-Johnson, Christine E Kistler, Alison M Stuebe
Postpartum contraceptive decision-making is complex, and recommendations may be influenced by breastfeeding intentions. While biologically plausible, concerns about the adverse impact of hormonal contraception on breast milk production have not been supported by the clinical evidence to date. However, the data have limitations. Which can lead providers with different priorities around contraception and breastfeeding to interpret the data in a way that advances their personal priorities. Discrepancies in interpretations can lead to divergent recommendations for individual women, and may cause conflict...
November 10, 2018: Contraception
Sung Hwan Cho, Young Ran Kim, Ji Hyang Kim, Hui Jeong An, Jung Oh Kim, Jung Jae Ko, Woo Sik Lee, Nam Keun Kim
OBJECTIVE: The purpose of this study was to investigate the association of microRNA polymorphisms (miR-25T>C, miR-32C>A, miR-125C>T, and miR-222G>T) with primary ovarian insufficiency (POI) in Korean women. METHODS: We conducted a case-control study of Korean women: 142 participants with POI and 266 controls with at least 1 live birth and no history of pregnancy loss. RESULTS: The haplotype-based multifactor dimensionality reduction analysis revealed that the T-C-T-G (miR-25/-32/-125/-222), T-A-C-G (miR-25/-32/-125/-222), C-T-G (miR-32/-125/-222), A-C-G (miR-32/-125/-222), T-G (miR-122/-222), C-T (miR-32/-125), and C-C (miR-25/-32) inferred haplotypes were significantly less frequent in POI (P < 0...
November 12, 2018: Menopause: the Journal of the North American Menopause Society
Marcos Gonçalves de Rezende, Cybele Garcia-Leal, Marcos Felipe Silva de Sá, Ricardo de Carvalho Cavalli, Cristina Marta Del-Ben
The aim of this study was to verify if the fall of plasma concentrations of steroid hormones in the first 12 h postpartum would be associated with changes in the same period in the emotional state of healthy women. Subjective and hormonal data were collected from 14 women (28.5 ± 7.1 years old) at zero (only hormones), 1, 2, 6 and 12 h after delivery. Subjective measures were taken using the Visual Analogue Mood Scale (VAMS), which consists of four factors (anxiety, sedation, discomfort, and cognitive impairment)...
November 2, 2018: Psychoneuroendocrinology
Sheng Wu, Ping Xue, Neile Grayson, Jeffrey S Bland, Andrew Wolfe
Polycystic ovary syndrome (PCOS) results from functional ovarian hyperandrogenism due to dysregulation of androgen secretion. Cultured theca cells from polycystic ovaries of women with the most common form of PCOS overexpress most androgen producing enzymes, particularly CYP450c17. This study used a murine model of PCOS induced by chronic feeding with high fat content diet that exhibits the reproductive, hyperandrogenic, and metabolic constellation of symptoms of PCOS seen in women. Oral administration of KDT501, a hops-derived bitter taste receptor (Tas2R 108) isohumulone ligand resulted in resolution of PCOS-associated endocrine and metabolic disturbances and restored reproductive function...
November 9, 2018: Endocrinology
Carolyn M Webb, Peter Collins
Cardiovascular disease (CVD) is the most prevalent non-communicable cause of death worldwide. Testosterone is a sex hormone that is predominant in males but also occurs in lower concentrations in females. It has effects directly on the blood vessels of the cardiovascular system and on the heart, as well as effects on risk factors for CVD. Serum testosterone concentrations are known to decrease with age and reduced testosterone levels are linked to premature coronary artery disease, unfavourable effects on CVD risk factors and increased risk of cardiovascular mortality independent of age...
December 2017: European Cardiology
N Chabbert-Buffet, H Marret, A Agostini, C Cardinale, N Hamdaoui, D Hassoun, A P Jonville-Bera, M Lambert, T Linet, C Pienkowski, G Plu-Bureau, D Pragout, G Robin, C Rousset Jablonski, M Scheffler, F Vidal, S Vigoureux, B Hédon
The French College of Obstetrics and Gynecology (CNGOF) releases its first global recommendations for clinical practice in contraception, to provide physicians with an updated synthesis of available data as a basis for their practice. The French Health Authority (HAS) methodology was used. Twelve practical issues were selected by the organizing committee and the task force members. The available literature was screened until December 2017, and allowed the release of evidence-based, graded recommendations. This synthesis is issued from 12 developed texts, previously reviewed by experts and physicians from public and private practices, with an experience in the contraceptive field...
November 9, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
S Vigoureux, M Le Guen
OBJECTIVE: To summarize current knowledge on contraceptive coverage in France and worldwide, describe the effectiveness of different types of contraceptives, describe the characteristics of women using contraception, contraceptive failure situations and describe the different medical risks associated with contraceptive methods. METHODS: Consultation of the Medline database and of national or international reports on contraception. RESULTS: Contraceptive coverage in France is high: 97% of women in 2013 use a contraceptive method (among fertile, sexually active women without a desire for pregnancy), with a majority using medical methods (72% using pills and other hormonal contraceptives, intrauterine devices and 25% using natural and traditional barrier methods)...
November 8, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
Bobette Matulonga-Diakiese, Dominique Courbon, Agnès Fournier, Margaux Sanchez, Annabelle Bédard, Sylvie Mesrine, Camille Taillé, Gianluca Severi, Gabriel Thabut, Raphaëlle Varraso, Bénédicte Leynaert
BACKGROUND: The gender switch in asthma incidence around puberty has been put forward to suggest a role of sex hormones in asthma. However, there are limited and inconsistent findings on change in asthma incidence with menopause. We aimed to investigate the associations between menopause and asthma incidence, and interactions with overweight/obesity. METHODS: Asthma incidence was assessed in 67,872 women free of asthma at baseline (aged 41-68 years) and regularly followed up as a part of the French E3N cohort...
December 2018: Maturitas
Kristen Upson, Margaret A Adgent, Ganesa Wegienka, Donna D Baird
STUDY QUESTION: Is soy formula feeding during infancy associated with menstrual pain in reproductive-age women? SUMMARY ANSWER: Our data suggest that soy formula feeding during infancy is associated with several indicators of severe menstrual pain in reproductive-age women. WHAT IS KNOWN ALREADY: A prior study observed greater severity of menstrual pain in young women who as infants participated in feeding studies and were assigned to soy-based formula feeding...
November 9, 2018: Human Reproduction
N K Akhkubekova, A S Kaysinova, A A Fedorov, N B Efimenko, I I Gaidamaka, E N Chalaja, L A Cherevashchenko, L V Tsallagova, E E Urvacheva, A B Ovsienko
BACKGROUND: The use of agonists of gonadotropin-releasing hormone (GnRH) for the rehabilitation treatment of the patients presenting with endometriosis genitalis externa is known to significantly enhance the risk of development of hypoestrogenism. The so-called 'add-back-therapy' is carried out as a preventive measure to eliminate hypoestrogenism caused by the intake of GnRH agonists without detriment to the effectiveness of anti-hormonal therapy. AIM: The objective of the present study was to estimate the effectiveness of the new method ('add-back hormone replacement therapy') in comparison with anti-hormonal therapy with the use of GRH agonists at the stage of the early postoperative medical rehabilitation based on the drinking of mineral waters (MW) and radon therapy (RT) in the patients who had undergone the laparoscopic interventions for the treatment of endometrioid heterotopies of the ovaries (1-3 months post-operatively)...
2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
Jing-Min Dong, Hong-Xia Wang, Xiao-Fei Zhong, Kun Xu, Jia Bian, Yan Feng, Liang Chen, Lin Zhang, Xia Wang, De-Jing Ma, Bin Wang
This study aimed to analyze the relationship between pathologic complete response (pCR) and changes in background parenchymal enhancement (BPE) levels in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer and who received neoadjuvant chemotherapy (NAC).The pre- and post-NAC magnetic resonance imaging results of 51 patients with confirmed unilateral HER2-positive breast cancer were retrospectively analyzed by 2 experienced radiologists. Pre- and post-NAC of contralateral BPE levels were classified into 4 categories (1 = minimal, 2 = mild, 3 = moderate, and 4 = marked)...
October 2018: Medicine (Baltimore)
Andrei Miclea, Anke Salmen, Greta Zoehner, Lara Diem, Christian P Kamm, Panos Chaloulos-Iakovidis, Marius Miclea, Myriam Briner, Kostas Kilidireas, Leonidas Stefanis, Andrew Chan, Maria Eleftheria Evangelopoulos, Robert Hoepner
INTRODUCTION: Multiple sclerosis (MS) is an autoimmune disease of the CNS, which predominantly affects women. Studies investigating the sex distribution in MS are sparse. We aim to analyze the female-to-male ratio (F/M ratio) in different MS phenotypes in association with age at diagnosis and year of birth. METHODS: We performed a retrospective cross-sectional analysis by cumulating data (sex, year of birth, age at diagnosis, and MS phenotypes) from unpublished and published studies of the participating centers...
November 8, 2018: CNS Neuroscience & Therapeutics
Paolo Amori, Veronica Di Nardo, Gabriella Vitiello, Katlein Franca, Jana Hercogova, Uwe Wollina, Farah Daaboul, Georgi Tchernev, Torello Lotti
Vulvovaginal atrophy is a condition that affects women, although it is mainly associated with the onset of menopause mainly due to hormonal changes vulvovaginal laxity and mucosal atrophy can also affect women at different life stages such as after pregnancy or for cancer patients who have undergone chemo or endocrine therapy. This condition negatively influence quality of life, sexual desire, and self-confidence. Many therapies have been considered mainly with inconclusive or transient results in terms of benefit factor...
November 8, 2018: Dermatologic Therapy
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