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Stephanie Ishack, Aranzazu Mediero, Tuere Wilder, John L Ricci, Bruce N Cronstein
Bone defects resulting from trauma or infection need timely and effective treatments to restore damaged bone. Using specialized three-dimensional (3D) printing technology we have created custom 3D scaffolds of hydroxyapatite (HA)/beta-tri-calcium phosphate (β-TCP) to promote bone repair. To further enhance bone regeneration we have coated the scaffolds with dipyridamole, an agent that increases local adenosine levels by blocking cellular uptake of adenosine. Nearly 15% HA:85% β-TCP scaffolds were designed using Robocad software, fabricated using a 3D Robocasting system, and sintered at 1100°C for 4 h...
October 29, 2015: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Daniele Lana, Alessia Melani, Anna Maria Pugliese, Sara Cipriani, Daniele Nosi, Felicita Pedata, Maria Grazia Giovannini
Chronic cerebral hypoperfusion during aging may cause progressive neurodegeneration as ischemic conditions persist. Proper functioning of the interplay between neurons and glia is fundamental for the functional organization of the brain. The aim of our research was to study the pathophysiological mechanisms, and particularly the derangement of the interplay between neurons and astrocytes-microglia with the formation of "triads," in a model of chronic cerebral hypoperfusion induced by the two-vessel occlusion (2VO) in adult Wistar rats (n = 15)...
2014: Frontiers in Aging Neuroscience
Ercole Tagliamonte, Fausto Rigo, Teresa Cirillo, Costantino Astarita, Gaetano Quaranta, Umberto Marinelli, Archimede Caruso, Carlo Romano, Nicola Capuano
INTRODUCTION: Ranolazine reduces the Na-dependent calcium overload via inhibition of the late sodium current, improving diastolic tone and oxygen handling during myocardial ischemia. In patients with angina, evidence of myocardial ischemia, but no obstructive coronary artery disease (CAD), abnormal coronary autoregulation plays a key role. Transthoracic Doppler-derived coronary flow reserve (CFR) is an index of coronary arterial reactivity and decreases in both microvascular dysfunction and coronary artery stenosis...
March 2015: Echocardiography
Stavros Apostolakis, Gregory Yh Lip, Eduard Shantsila
INTRODUCTION: Strategies to prevent stroke recurrences and stroke-related morbidity and mortality are a major concern for healthcare systems worldwide. Antithrombotic therapy is the cornerstone for the secondary prevention of ischemic stroke. AREAS COVERED: This article is an overview of currently used antithrombotic therapies in the management of ischaemic stroke with special focus on their pharmacokinetic properties and how these properties may influence their clinical utility...
October 2013: Expert Opinion on Drug Metabolism & Toxicology
A Florian, R Jurcut, C Ginghina, J Bogaert
Cardiac magnetic resonance imaging (MRI) has emerged as a prime player in the clinical and preclinical detection of ischemic heart disease (IHD) as well in the prognosis assessment by offering a comprehensive approach for all spectrums of coronary artery disease (CAD) patients. The aim of this review is to provide the reader a state-of-the art on how the newest cardiac MRI techniques can be used to study IHD patients. In patients with suspected/stable CAD, functional and perfusion imaging both at rest and during vasodilatatory stress (adenosine, dypiridamole)/dobutamine stress can accurately depict ischemic myocardium secondary to significant coronary artery stenosis...
November 14, 2011: Journal of Medicine and Life
Maria Czarina Acelajado, Suzanne Oparil
Transient ischemic attack (TIA) is currently defined as a transient episode of neurologic dysfunction caused by focal brain, spinal cord, or retinal ischemia without infarction. TIA is an important risk factor for stroke and other major vascular events. Risk factors for TIA or stroke need to be addressed effectively to reduce the risk for stroke in patients who have had a TIA. Aspirin (ASA) significantly reduces the risk for stroke when given after a TIA, stroke, or myocardial infarction in a dose of 50 mg/d to 325 mg/d...
February 2012: Journal of Clinical Hypertension
Jesús del Pozo, Juan Carlos López-Gutiérrez, Manuel Gómez-Tellado, Manuel Nistal, Rafaela Soler, Felipe Sacristán, J A Tovar
According to International Society for the Study of Vascular Anomalies classification, vascular anomalies are mainly divided into two groups: vascular tumors and vascular malformations. Nevertheless, a small group of patients present clinical and/or histopathologic overlapping features. We report a case of a 4-month-old boy that presented a vascular lesion on his right buttock with involvement of abdominal wall muscles, abdominal cavity and drainage to primitive iliac by a tortuous drainage vein. Surgery was performed and histopathology demonstrated a combined vascular malformation...
July 2011: Pediatric Dermatology
Sofia Theodoropoulou, Paraskevi E Kolovou, Yuki Morizane, Maki Kayama, Fotini Nicolaou, Joan W Miller, Evangelos Gragoudas, Bruce R Ksander, Demetrios G Vavvas
5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR), an analog of AMP, is widely used as an activator of AMP-kinase (AMPK), a protein that regulates the responses of the cell to energy change. We studied the effects of AICAR on the growth of retinoblastoma cell lines (Y79, WERI, and RB143). AICAR inhibited Rb cell growth, induced apoptosis and S-phase cell cycle arrest, and led to activation of AMPK. These effects were abolished by treatment with dypiridamole, an inhibitor that blocks entrance of AICAR into cells...
August 2010: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
R A Tio, R H J A Slart, R A de Boer, P A van der Vleuten, R M de Jong, L M van Wijk, T Willems, D D Lubbers, A A Voors, D J van Veldhuisen
Background. In idiopathic dilated cardiomyopathy (IDC) an imbalance between myocardial oxygen consumption and supply has been postulated. Subclinical myocardial ischaemia may contribute to progressive deterioration of left ventricular function. The relation between regional myocardial perfusion reserve (MPR) and contractile performance was investigated.Methods. Patients with newly diagnosed IDC underwent positron emission tomography (PET) scanning using both (13)N-ammonia as a perfusion tracer (baseline and dypiridamole stress), and (18)F-fluorodeoxyglucose viability tracer and a dobutamine stress MRI...
December 2009: Netherlands Heart Journal
Yazan Alabed, Stephan Probst, Rajan Rakheja, Gordon Crelinsten, Marc Hickeson
A 69-year-old man with remote gastric pull-up was evaluated with a 2-day stress-rest dypiridamole Tc-99m sestamibi myocardial perfusion imaging, where significant tracer uptake was noted in the posterior mediastinum related to enterogastric reflux of sestamibi. These ancillary findings were suggestive of a noncardiac etiology of the patient's atypical chest pain. This case highlights the value of examining the raw projection images for incidental findings that may be present during myocardial perfusion imaging...
September 2009: Clinical Nuclear Medicine
Luís Alberto Oliveira Dallan, Luís Henrique Gowdak, Luiz Augusto Ferreira Lisboa, Isolmar Schettert, José Eduardo Krieger, Luiz Antonio Machado Cesar, Sérgio Almeida de Oliveira, Noedir Antonio Groppo Stolf
OBJECTIVE: We tested the hypothesis that TMLR combined with intramyocardial injection of BMC is safe, and may help increase the functional capacity of patient with refractory angina. METHODS: Nine patients (eight men), 65+/-5 years old, with refractory angina for multivessel disease and previous myocardial revascularization procedures (CABG/PCI), not candidates for another procedure due to the extension of the disease were enrolled. TMLR (11+/-3 laser drills) was performed via a limited thoracotomy using a CO2 Heart Laser System...
January 2008: Revista Brasileira de Cirurgia Cardiovascular
Ana G Almeida, Francisco Araújo, Fernanda Rego, Cláudio David, Mário G Lopes, J Ducla-Soares
BACKGROUND: Sickle cell disease (SCD) is characterized by obstruction of microvessels leading to ischemia and necrosis. We have aimed to demonstrate whether myocardial contrast echocardiography (MCE) is able to detect myocardial perfusion abnormalities in SCD patients and to assess their relationship with left ventricle (LV) perfusion and systolic function. METHODS: A group of 25 patients with SCD and a control group of 19 normal individuals were studied. Using MCE, myocardial perfusion reserve indices (A, beta, and A x beta) were obtained, before and after hyperemia with dypiridamole...
July 2008: Echocardiography
Enrique Asensio-Lafuente, Lilia Castillo-Martínez, Arturo Orea-Tejeda, Rubén Silva-Tinoco, Joel Dorantes-García, René Narváez-David, Verónica Rebollar-González
BACKGROUND: Heart failure (HF) patients can benefit from a proper RS. We had observed that they show an increase in the number of arrhythmias during the first year of pharmacological treatment. METHODS: We carried out a prospective observational study in which patients in an HF Clinic were included when they had follow-up Holter monitoring. Patients also had a baseline myocardial perfusion scan (Tc99 sestaMIBI/dypiridamole) and a control scan. RESULTS: We included 90 patients with follow-up Holter and 35 with scintigraphy, for analysis...
2008: Cardiology Journal
V Bodi, J Sanchis, M P Lopez-Lereu, J Nunez, L Mainar, J V Monmeneu, V Ruiz, E Rumiz, O Husser, D Moratal, J Millet, F J Chorro, A Llacer
OBJECTIVE: To determine the prognostic and therapeutic implications of stress perfusion cardiovascular magnetic resonance (CMR) on the basis of the ischaemic cascade. SETTING: Single centre study in a teaching hospital in Spain. PATIENTS: Dipyridamole stress CMR was performed on 601 patients with ischaemic chest pain and known or suspected coronary artery disease. On the basis of the ischaemic cascade, patients were categorised in C1 (no evidence of ischaemia, n = 354), C2 (isolated perfusion deficit at stress first-pass perfusion imaging, n = 181) and C3 (simultaneous perfusion deficit and inducible wall motion abnormalities, n = 66)...
January 2009: Heart: Official Journal of the British Cardiac Society
Silvana Morello, Antonello Petrella, Michela Festa, Ada Popolo, Mario Monaco, Emilia Vuttariello, Gennaro Chiappetta, Luca Parente, Aldo Pinto
A3 adenosine receptor (A3AR) agonists have been reported to modulate cellular proliferation. This work was aimed to investigate the expression and the possible implication of A3AR in the human thyroid carcinomas. Normal thyroid tissue samples did not express A3 adenosine receptor, while primary thyroid cancer tissues expressed high level of A3AR, as determined by immunohistochemistry analysis. In human papillary thyroid carcinoma cell line, NPA, at concentrations > or =10 microM, the A3AR-selective agonist 2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide (Cl-IB-MECA) produced inhibition of cell growth, by blocking the G(1) cell cycle phase in a concentration- and time-dependent manner...
February 2008: Cancer Biology & Therapy
Takeo Ishii, Tetsuya Kawamura, Nobuo Tsuboi, Makoto Ogura, Yasunori Utsunomiya, Tatsuo Hosoya
We previously reported that a combined therapy with heparin/warfarin and renin-angiotensin system (RAS) inhibitors dramatically reduces proteinuria for prolonged periods in advanced IgA nephropathy (IgAN). In the present study, we prospectively analyzed whether the combined therapy can inhibit the progressive decline in renal function of patients with progressive IgAN. Patients who had a marked linearity of decline in loss of glomerular filtration rate (GFR), assessed by reciprocal serum creatinine plots vs...
2007: Contributions to Nephrology
Stefania Gessi, Stefania Merighi, Katia Varani, Elena Cattabriga, Annalisa Benini, Prisco Mirandola, Edward Leung, Stephen Mac Lennan, Carlo Feo, Stefania Baraldi, Pier Andrea Borea
Adenosine may affect several pathophysiological processes, including cellular proliferation, through interaction with A(1), A(2A), A(2B), and A(3) receptors. In this study we characterized adenosine receptors in human colon cancer tissues and in colon cancer cell lines Caco2, DLD1, HT29. mRNA of all adenosine subtypes was detected in cancer tissues and cell lines. At a protein levels low amount of A(1), A(2A), and A(2B) receptors were detected, whilst the A(3) was the most abundant subtype in both cancer tissues and cells, with a pharmacological profile typical of the A(3) subtype...
June 2007: Journal of Cellular Physiology
Manuel Díaz de Leén-Ponce, Armando Alberto Moreno-Santillán, Jorge Iván González-Díaz, Jesús Carlos Briones-Garduño
BACKGROUND: Toxic epidermal necrolysis is a dermatological disease that evolves with an elevated mortality. Our objective was to show the utility of a nonconventional treatment for toxic epidermal necrolysis in place of conventional treatment where the mortality is <50 %. With this suggested treatment, mortality is 0 %. METHODS: This is a prospective and descriptive study presenting the case of 12 patients with toxic epidermal necrolysis. Diagnosis was made by history of drug ingestion, clinical presentation and skin biopsy, which was corroborated by light microscopy...
January 2006: Cirugia y Cirujanos
M Egred, G D Waiter, S I K Semple, T W Redpath, A Al-Mohammad, M Y Norton, M J Metcalfe, S Walton
BACKGROUND: Blood oxygen level-dependent (BOLD) MRI relies on changes in deoxyhaemoglobin level in tissues under stress for signal variation and may be used for detection of ischaemic myocardium. METHODS: 15 patients with stress induced myocardial ischaemia on PET scanning underwent rest and dypiridamole stress MRI using a double breath-hold T2-weighted, ECG gated sequence to produce BOLD contrast images and cine-MRI for wall thickening assessment. Signal change on BOLD MRI and wall thickening were compared between rest and stress images in ischaemic and non-ischaemic myocardial segments...
January 31, 2007: International Journal of Cardiology
Isabella Bruno, Gianluigi Bencardino, Maria Grazia Spitilli, Milena Pizzoferro, Manuela Totaro, Donatella Pia Dambra, Luisa Lo Conte, Alessandro Giordano
The case of a 72-year-old patient affected by myasthenia gravis under pyridostigmine therapy, admitted to the hospital for the onset of oppressive thoracic pain associated with mild enzyme increase, electrocardiographic and echocardiographic disorders, is discussed. Dypiridamole/gated SPECT perfusion scintigraphy at rest evidenced reduced coronary reserve at the level of the lateral wall with apical akinesia and normokinesia of mediobasal left ventricle. On coronarography, coronary arteries were free of significant stenoses and left ventricular apical akinesia...
July 2005: Rays
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