keyword
MENU ▼
Read by QxMD icon Read
search

Very early rheumatoid arthritis

keyword
https://www.readbyqxmd.com/read/28629689/advanced-power-doppler-technique-increases-synovial-vascularity-detection-in-patients-with-rheumatoid-arthritis
#1
Davide Orlandi, Salvatore Gitto, Silvia Perugin Bernardi, Angelo Corazza, Luca De Flaviis, Enzo Silvestri, Marco Amedeo Cimmino, Luca Maria Sconfienza
We compared the diagnostic performance of an advanced power Doppler technique (superb microvascular imaging [SMI]) with that of power Doppler Imaging (PDI) and B-mode ultrasound (US) in patients with early rheumatoid arthritis (RA) and RA under treatment with rituximab. Thirty patients (21 women aged 45 ± 11 y) affected by RA with remission to moderate disease activity were examined. Both hand joints were evaluated using US, PDI and SMI. Two radiologists reviewed all video clips and evaluated synovial vascularity intensity using a semi-quantitative scoring system...
June 16, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28583280/clinical-value-of-fdg-pet-ct-for-the-evaluation-of-rheumatic-diseases-rheumatoid-arthritis-polymyalgia-rheumatica-and-relapsing-polychondritis
#2
REVIEW
Kazuo Kubota, Hiroyuki Yamashita, Akio Mimori
FDG is a tracer for visualizing glucose metabolism. PET/CT using FDG is widely used for the diagnosis of cancer, because glycolysis is elevated in cancer cells. Similarly, active inflammatory tissue also exhibits elevated glucose metabolism because of glycolysis in activated macrophages and proliferating fibroblasts. Elevated FDG uptake by active inflammatory tissues, such as those affected by arthritis, vasculitis, lymphadenitis, and chondritis, has enabled the diagnosis of inflammatory diseases using FDG-PET/CT...
July 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28581281/a-case-of-rheumatoid-vasculitis-involving-hepatic-artery-in-early-rheumatoid-arthritis
#3
Ji Eun Lee, In Je Kim, Min Sun Cho, Jisoo Lee
Rheumatoid vasculitis is a rare, but most serious extra-articular complications of long-standing, seropositive rheumatoid arthritis (RA). Vasculitis of hepatic artery is an extremely rare but severe manifestation of rheumatoid vasculitis. A 72-year-old woman who presented with polyarthralgia for 2 months was diagnosed with early RA. Since she had manifestations of livedo reticularis, and liver dysfunction which was atypical for RA patients, a percutaneous needle liver biopsy was performed revealing arteritis of a medium-sized hepatic artery...
July 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28493323/early-changes-of-the-cortical-micro-channel-system-in-the-bare-area-of-the-joints-of-patients-with-rheumatoid-arthritis
#4
David Werner, David Simon, Matthias Englbrecht, Fabian Stemmler, Christoph Simon, Andreas Berlin, Judith Haschka, Nina Renner, Thomas Buder, Klaus Engelke, Axel J Hueber, Jürgen Rech, Georg Schett, Arnd Kleyer
OBJECTIVE: To characterize the specific structural properties of the erosion-prone bare area of the human joint, and to search for early microstructural changes in this region during rheumatoid arthritis (RA). METHODS: In the initial part of the study, human cadaveric hand joints were examined for exact localization of the bare area of the metacarpal heads, followed by detection of cortical micro-channels (CoMiCs) in this region by high-resolution peripheral quantitative computed tomography (HR-pQCT) and, after anatomic dissection, validation of the presence of CoMiCs by micro-computed tomography (micro-CT)...
May 10, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28493174/genomics-transcriptomics-and-proteomics-to-elucidate-the-pathogenesis-of-rheumatoid-arthritis
#5
REVIEW
Xinqiang Song, Qingsong Lin
Rheumatoid arthritis is an autoimmune disease that affects several organs and tissues, predominantly the synovial joints. The pathogenesis of this disease is not completely understood, which maybe involved in the genomic variations, gene expression, protein translation and post-translational modifications. These system variations in genomics, transcriptomics and proteomics are dynamic in nature and their crosstalk is overwhelmingly complex, thus analyzing them separately may not be very informative. However, various '-omics' techniques developed in recent years have opened up new possibilities for clarifying disease pathways and thereby facilitating early diagnosis and specific therapies...
May 10, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28480094/validation-of-leiden-score-in-predicting-progression-of-rheumatoid-arthritis-in-undifferentiated-arthritis-in-indian-population
#6
K Ghosh, A Chatterjee, S Ghosh, S Chakraborty, P Chattopadhyay, A Bhattacharya, M Pal
BACKGROUND: Leiden Score, is a very useful tool for predicting future development of rheumatoid arthritis (RA), among undifferentiated arthritis (UA) patients. This score has been validated in various western studies but rarely among south east Asian patients. AIMS: To validate the Leiden early arthritis prediction rule in an Indian cohort of patients for predicting rheumatoid arthritis (RA) in undifferentiated arthritis (UA) patients and to formulate any simpler version of prediction score taking only clinical variables of original Leiden prediction rule...
July 2016: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/28442886/hydroxychloroquine-for-treatment-of-rheumatoid-arthritis-multifocal-electroretinogram-and-laser-flare-cell-photometry-study
#7
Stefano Sebastiani, Michela Fresina, Mauro Cellini, Emilio C Campos
PURPOSE: To evaluate early changes in multifocal electroretinogram (mfERG) and subclinical aqueous humor flare and cellularity in patients receiving hydroxychloroquine (HCQ) as treatment for rheumatoid arthritis. METHODS: Ten patients receiving treatment with HCQ and no ophthalmic symptoms were enrolled. After complete ocular examination, mfERG and laser flare-cell photometry were performed. Patients were also divided into two subgroups with HCQ cumulative dose (CD) higher or lower than 500 g...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28425620/periarticular-bone-loss-in-arthritis-is-induced-by-autoantibodies-against-citrullinated-vimentin
#8
Cecilia Engdahl, Holger Bang, Katharina Dietel, Stefanie C Lang, Ulrike Harre, Georg Schett
Periarticular bone loss is a long known but yet insufficiently understood phenomenon in patients with rheumatoid arthritis. This study investigated whether autoimmunity against citrullinated proteins is causally involved in triggering periarticular bone loss. Periarticular bone loss was studied in the standard antigen induced arthritis (AIA) mouse model with methylated bovine serum albumin (mBSA) as well as modified model with mutated citrullinated vimentin (MCV) alone or in combination with mBSA. Periarticular bone loss, subchondral osteoclastogenesis as well as local expression of cytokines, osteoclast genes and PAD enzymes were assessed after arthritis induction...
April 20, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28293454/can-rheumatoid-vasculitis-predate-a-diagnosis-of-rheumatoid-arthritis
#9
Sarah Sacks, Alan Steuer
We report regarding a male patient who presented with a systemic vasculitis that was consistent with a diagnosis of polyarteritis nodosa. At presentation, he had no features of inflammatory arthritis but had a high rheumatoid factor titer and low C4 level. Withdrawal of immunosuppression after 6 years resulted in the development of classical rheumatoid arthritis (RA). This case supports previous reports that revealed that vasculitis may predate the development or occur very early in the course of articular RA...
March 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28285723/epigenetic-aspects-of-rheumatoid-arthritis-contribution-of-non-coding-rnas
#10
REVIEW
Bogdan Kolarz, Maria Majdan
Since microRNA was discovered in the late 1990s the role of non-coding RNAs in the regulation of cellular processes has been confirmed. Intensive researches have revealed a number of subtypes of non-coding RNA. It has been proved that these molecules can influence each step of the development of cells and tissues. Moreover, researchers have found their expression change during disease development. In this article, we gathered the current results on the contribution of microRNA and long non-coding RNA in rheumatoid arthritis pathogenesis and their potential use in rheumatoid arthritis treatment...
June 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28264816/eular-recommendations-for-the-management-of-rheumatoid-arthritis-with-synthetic-and-biological-disease-modifying-antirheumatic-drugs-2016-update
#11
Josef S Smolen, Robert Landewé, Johannes Bijlsma, Gerd Burmester, Katerina Chatzidionysiou, Maxime Dougados, Jackie Nam, Sofia Ramiro, Marieke Voshaar, Ronald van Vollenhoven, Daniel Aletaha, Martin Aringer, Maarten Boers, Chris D Buckley, Frank Buttgereit, Vivian Bykerk, Mario Cardiel, Bernard Combe, Maurizio Cutolo, Yvonne van Eijk-Hustings, Paul Emery, Axel Finckh, Cem Gabay, Juan Gomez-Reino, Laure Gossec, Jacques-Eric Gottenberg, Johanna M W Hazes, Tom Huizinga, Meghna Jani, Dmitry Karateev, Marios Kouloumas, Tore Kvien, Zhanguo Li, Xavier Mariette, Iain McInnes, Eduardo Mysler, Peter Nash, Karel Pavelka, Gyula Poór, Christophe Richez, Piet van Riel, Andrea Rubbert-Roth, Kenneth Saag, Jose da Silva, Tanja Stamm, Tsutomu Takeuchi, René Westhovens, Maarten de Wit, Désirée van der Heijde
Recent insights in rheumatoid arthritis (RA) necessitated updating the European League Against Rheumatism (EULAR) RA management recommendations. A large international Task Force based decisions on evidence from 3 systematic literature reviews, developing 4 overarching principles and 12 recommendations (vs 3 and 14, respectively, in 2013). The recommendations address conventional synthetic (cs) disease-modifying antirheumatic drugs (DMARDs) (methotrexate (MTX), leflunomide, sulfasalazine); glucocorticoids (GC); biological (b) DMARDs (tumour necrosis factor (TNF)-inhibitors (adalimumab, certolizumab pegol, etanercept, golimumab, infliximab), abatacept, rituximab, tocilizumab, clazakizumab, sarilumab and sirukumab and biosimilar (bs) DMARDs) and targeted synthetic (ts) DMARDs (Janus kinase (Jak) inhibitors tofacitinib, baricitinib)...
June 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28213564/seven-year-tolerability-profile-of-glucocorticoids-use-in-early-rheumatoid-arthritis-data-from-the-espoir-cohort
#12
Camille Roubille, Nathalie Rincheval, Maxime Dougados, René-Marc Flipo, Jean-Pierre Daurès, Bernard Combe
OBJECTIVE: To explore the 7-year tolerability profile of glucocorticoids (GC) for early rheumatoid arthritis (RA). METHODS: We examined data for 602 patients with RA from the early arthritis Etude et Suivi des POlyarthrites Indifférenciées Récentes (ESPOIR) cohort (<6 months disease duration) stratified into two groups: with or without GC treatment at least once during follow-up (median 7 years (IQR 0.038-7.65)). The main outcome was a composite of death, cardiovascular disease (including myocardial ischaemia, cerebrovascular accident and heart failure), severe infection and fracture...
February 17, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28183987/in-vivo-hypoxia-pet-imaging-quantifies-the-severity-of-arthritic-joint-inflammation-in-line-with-overexpression-of-hypoxia-inducible-factor-and-enhanced-reactive-oxygen-species-generation
#13
Kerstin Fuchs, Anna Kuehn, Moritz Mahling, Philipp Guenthoer, Andreas Hector, Johannes Schwenck, Dominik Hartl, Stefan Laufer, Ursula Kohlhofer, Leticia Quintanilla-Martinez, Gerald Reischl, Martin Röcken, Bernd J Pichler, Manfred Kneilling
Hypoxia is essential for the development of autoimmune diseases such as rheumatoid arthritis (RA) and is associated with the expression of reactive oxygen species (ROS), because of the enhanced infiltration of immune cells. The aim of this study was to demonstrate the feasibility of measuring hypoxia noninvasively in vivo in arthritic ankles with PET/MRI using the hypoxia tracers (18)F-fluoromisonidazole ((18)F-FMISO) and (18)F-fluoroazomycinarabinoside ((18)F-FAZA). Additionally, we quantified the temporal dynamics of hypoxia and ROS stress using L-012, an ROS-sensitive chemiluminescence optical imaging probe, and analyzed the expression of hypoxia-inducible factors (HIFs)...
May 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28159704/effects-of-targeted-therapies-on-the-bone-in-arthritides
#14
REVIEW
Ágnes Szentpétery, Ágnes Horváth, Katalin Gulyás, Zsófia Pethö, Harjit Pal Bhattoa, Sándor Szántó, Gabriella Szücs, Oliver FitzGerald, Georg Schett, Zoltán Szekanecz
Inflammatory arthritides, such as rheumatoid arthritis (RA) and spondyloarthritides (SpA) have been associated with both localized bone resorption and/or formation, and generalized osteoporosis. Systemic inflammation may be the major driver for bone loss in arthritis. In RA and peripheral SpA the RANK-RANKL-OPG network is involved in bone resorption, while in axial SpA the Wnt-β-catenin axis and its inhibitors (DKK-1, sclerostin) are the most relevant. Targeted therapies including biologics and small molecule tyrosine kinase inhibitors may interfere with inflammatory bone metabolism...
March 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28089976/disease-characteristics-and-rheumatoid-arthritis-development-in-patients-with-early-undifferentiated-arthritis-a-2-year-followup-study
#15
Gina H Brinkmann, Ellen S Norli, Tore K Kvien, Anne J Haugen, Lars Grøvle, Halvor Nygaard, Olav Bjørneboe, Cathrine Thunem, Maria D Mjaavatten, Elisabeth Lie
OBJECTIVE: To examine the 2-year disease course in patients with undifferentiated arthritis (UA) focusing on fulfillment of the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) rheumatoid arthritis (RA) classification criteria. METHODS: Data were provided by the Norwegian Very Early Arthritis Clinic study, which included patients presenting with ≥ 1 swollen joint of ≤ 16 weeks' duration. UA was defined as patients not fulfilling the 2010 ACR/EULAR RA criteria and who did not have a clinical diagnosis other than RA at baseline...
February 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/27943044/anti-mcv-antibodies-predict-radiographic-progression-in-greek-patients-with-very-early-3%C3%A2-months-duration-rheumatoid-arthritis
#16
Georgia Barouta, Christina G Katsiari, Ioannis Alexiou, Christos Liaskos, Areti Varna, Dimitrios P Bogdanos, Anastasios E Germenis, Lazaros I Sakkas
This study aimed to assess the diagnostic and prognostic value of anti-mutated citrullinated vimentin (MCV) antibodies in very early rheumatoid arthritis (VERA) and in established rheumatoid arthritis (RA). Seventy-one patients with undifferentiated arthritis (UA) of <3 months duration, 141 with established RA, 53 with other rheumatic diseases, and 40 healthy individuals were included in the study. Anti-MCV, anti-cyclic citrullinated peptide (CCP) antibodies, and rheumatoid factor (RF) were determined and hand radiographs were recorded...
April 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/27910962/baricitinib-jak-inhibition-for-rheumatoid-arthritis
#17
REVIEW
J Gras
Rheumatoid arthritis (RA), a chronic autoimmune inflammatory disease characterized by inflammation and joint destruction, is associated with pain, progressive disability, systemic comorbidities and early death. Conventional disease-modifying antirheumatic drugs (DMARDs) and biological DMARDs (bDMARDs) have been able to achieve remission or a very low disease activity status for RA. Nevertheless, since many patients do not reach a sufficient response with DMARDs or present with unacceptable side effects, new therapies are needed...
October 2016: Drugs of Today
https://www.readbyqxmd.com/read/27856654/adverse-events-of-glucocorticoids-during-treatment-of-rheumatoid-arthritis-lessons-from-cohort-and-registry-studies
#18
REVIEW
Johannes W J Bijlsma, Frank Buttgereit
Glucocorticoids have now been used for >65 years in the treatment of RA. There is good evidence for their disease-modifying effect, especially in early RA. When used in a dosage of 7.5-10 mg/day, most adverse effects can be handled quite well, although monitoring for and awareness of infections are important. Adverse events may have been overreported, due to bias by indication, but pose an important drawback in the use of these very effective anti-inflammatory and immune-modulatory drugs. Daily dosages >7...
December 2016: Rheumatology
https://www.readbyqxmd.com/read/27807638/hormone-metabolic-peptide-and-nutrient-levels-in-the-earliest-phases-of-rheumatoid-arthritis-contribution-of-free-fatty-acids-to-an-increased-cardiovascular-risk-during-very-early-disease
#19
Man Wai Tang, Frieda A Koopman, Jan P M Visscher, Maria J de Hair, Danielle M Gerlag, Paul Peter Tak
Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with changes in several hormones and metabolic peptides. Crosstalk between these factors and the immune system may be important for homeostasis during inflammation. Here, we studied the levels of hormones, metabolic peptides, and nutrients in individuals at risk for developing RA (at risk). In total, 18 hormones, metabolic peptides, and nutrients were measured in fasting serum samples from 45 autoantibody-positive individuals at risk, 22 RA patients, and 16 healthy subjects...
February 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/27805330/diagnostic-accuracy-of-ultrasonography-in-detection-of-destructive-changes-in-small-joints-of-hands-in-patients-of-rheumatoid-arthritis-a-comparison-with-magnetic-resonance-imaging
#20
Sonal Saran, Meenu Bagarhatta, Renu Saigal
BACKGROUND: Ultrasonography can be used in early Rheumatoid Arthritis to determine and to follow parameters of joint inflammation, such as effusion, synovitis, and marginal erosion that can be radiologically occult. We therefore planned a study to investigate whether Ultrasonography could provide information on signs of inflammation and destruction in Rheumatoid Arthritis affected finger joints that was not available with Radiography and compared it to the information provided by Magnetic resonance imaging...
November 2016: Journal of the Association of Physicians of India
keyword
keyword
110615
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"