keyword
MENU ▼
Read by QxMD icon Read
search

Lactate AND Visceral fat

keyword
https://www.readbyqxmd.com/read/29401632/impaired-prolactin-actions-mediate-altered-offspring-metabolism-induced-by-maternal-high-fat-feeding-during-lactation
#1
Ericka A de Los Ríos, Xarubet Ruiz-Herrera, Viridiana Tinoco-Pantoja, Fernando López-Barrera, Gonzalo Martínez de la Escalera, Carmen Clapp, Yazmín Macotela
Maternal diet during lactation affects offspring metabolic health throughout life. Prolactin (PRL) is present in high quantities in maternal milk; however, the effects of milk PRL on the offspring remain poorly characterized. In this study, we evaluated whether feeding a high-fat diet (HFD) to rats during lactation alters PRL, both in the mother's serum and in milk, and whether this factor contributes to HFD-induced metabolic dysfunction in the offspring. Maternal HFD resulted in decreased PRL levels in milk (but not in serum), reduced mammary gland (MG) PRL receptor expression, and altered MG structure and function...
January 31, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29380149/litter-size-reduction-accentuates-maternal-care-and-alters-behavioral-and-physiological-phenotypes-in-rat-adult-offspring
#2
Silvia Enes-Marques, Alexandre Giusti-Paiva
Maternal behavior has a substantial impact on the behavioral, endocrine, and neural development of the pups. This study investigated the effect of altering the neonatal nutritional environment by modifying the litter size on maternal care and anxiety- and fear-like behaviors in rats during adulthood. On postnatal day (PND) 2, litters were adjusted to a small litter (SL) size of three pups per dam or normal litter (NL) size of 12 pups per dam. Maternal behaviors were scored daily during lactation (PND2-21). The weight gain, food intake, adiposity, and biochemical landmarks of offspring rats were evaluated...
January 27, 2018: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29375011/effect-of-the-japanese-diet-during-pregnancy-and-lactation-or-post-weaning-on-the-risk-of-metabolic-syndrome-in-offspring
#3
Haruna Ishikawa, Xiaoxu Guo, Saeko Sugawara, Yui Iwagaki, Kazushi Yamamoto, Tsuyoshi Tsuduki
We examined the effects on offspring of ingestion of the 1975 Japanese diet during pregnancy and lactation and after weaning in mice. Pregnant dams were divided into groups that were fed the Japanese diet or a control diet and raised until offspring were weaned. The offspring after weaning were further divided into groups that were raised on the Japanese diet or the control diet. Ingestion of the Japanese diet after weaning suppressed accumulation of visceral fat in offspring, and reduced the amount of lipids in serum and liver...
January 29, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29319751/effects-of-maternal-high-fat-intake-during-pregnancy-and-lactation-on-total-cholesterol-and-adipose-tissue-in-neonatal-rats
#4
M S Lima, G S Perez, G L Morais, L S Santos, G S Cordeiro, R D Couto, T C B J Deiró, C G Leandro, J M Barreto-Medeiros
AIM: Obesity during pregnancy is one of the most established risk factors for negative long-term programming. The aim of the present study was to investigate the effects of maternal consumption of a high-fat diet during pregnancy and lactation on the weight gain, visceral adipose tissue and cholesterolemia in neonatal rats. METHODS: Wistar rats were divided into two groups according to the mother's diet during pregnancy and lactation: Control group (CG, n = 12) were the offspring of rats fed a standard diet (4% lipid) and the Test group (TG, n = 12) were pups rats fed on a high fat diet (23% lipid)...
January 8, 2018: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/29222412/ancestral-perinatal-obesogen-exposure-results-in-a-transgenerational-thrifty-phenotype-in-mice
#5
Raquel Chamorro-Garcia, Carlos Diaz-Castillo, Bassem M Shoucri, Heidi Käch, Ron Leavitt, Toshi Shioda, Bruce Blumberg
Ancestral environmental exposures to non-mutagenic agents can exert effects in unexposed descendants. This transgenerational inheritance has significant implications for understanding disease etiology. Here we show that exposure of F0 mice to the obesogen tributyltin (TBT) throughout pregnancy and lactation predisposes unexposed F4 male descendants to obesity when dietary fat is increased. Analyses of body fat, plasma hormone levels, and visceral white adipose tissue DNA methylome and transcriptome collectively indicate that the F4 obesity is consistent with a leptin resistant, thrifty phenotype...
December 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/29186387/resveratrol-intake-during-pregnancy-and-lactation-modulates-the-early-metabolic-effects-of-maternal-nutrition-differently-in-male-and-female-offspring
#6
Purificación Ros, Francisca Díaz, Alejandra Freire-Regatillo, Pilar Argente-Arizón, Vicente Barrios, Jesús Argente, Julie A Chowen
Poor maternal nutrition can have detrimental long-term consequences on energy homeostasis in the offspring. Resveratrol exerts antioxidant and antiobesity actions, but its impact during development remains largely unknown. We hypothesized that resveratrol intake during pregnancy and lactation could improve the effects of poor maternal nutrition on offspring metabolism. Wistar rats received a low-fat diet (LFD; 10.2% kcal from fat) or high-fat diet (HFD; 61.6% kcal from fat), with half of each group receiving resveratrol in their drinking water (50 mg/L) during pregnancy and lactation...
February 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/29151452/development-of-a-new-diet-induced-obesity-dio-model-using-wistar-lean-rats
#7
Yoriko Kimura, Atsushi Yamada, Yoko Takabayashi, Tsunehiko Tsubota, Hisao Kasuga
Obesity is an increasingly severe socioeconomic health issue worldwide. Rodents with diet-induced obesity (DIO) are widely used as models of obesity. The main aim of this study was to establish a DIO model using Wistar lean (+/+ or +/-) rats by feeding a high-fat diet (45 kcal% fat) to dams during the latter term of gestation and the lactation period. A second aim was to examine the effect of post-weaning nutrition independently of maternal nutrition. Some pups (group D) were fed the same high-fat diet after weaning, while others (group C) were fed a chow diet after weaning...
November 17, 2017: Experimental Animals
https://www.readbyqxmd.com/read/29110748/perinatal-maternal-high-fat-diet-induces-early-obesity-and-sex-specific-alterations-of-the-endocannabinoid-system-in-white-and-brown-adipose-tissue-of-weanling-rat-offspring
#8
Mariana M Almeida, Camilla P Dias-Rocha, André S Souza, Mariana F Muros, Leonardo S Mendonca, Carmen C Pazos-Moura, Isis H Trevenzoli
Perinatal maternal high-fat (HF) diet programmes offspring obesity. Obesity is associated with overactivation of the endocannabinoid system (ECS) in adult subjects, but the role of the ECS in the developmental origins of obesity is mostly unknown. The ECS consists of endocannabinoids, cannabinoid receptors (cannabinoid type-1 receptor (CB1) and cannabinoid type-2 receptor (CB2)) and metabolising enzymes. We hypothesised that perinatal maternal HF diet would alter the ECS in a sex-dependent manner in white and brown adipose tissue of rat offspring at weaning in parallel to obesity development...
November 7, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29102876/maternal-high-fat-diet-induces-sex-specific-endocannabinoid-system-changes-in-newborn-rats-and-programs-adiposity-energy-expenditure-and-food-preference-in-adulthood
#9
Camilla P Dias-Rocha, Mariana M Almeida, Erika M Santana, Julia C B Costa, Juliana G Franco, Carmen C Pazos-Moura, Isis H Trevenzoli
Early life inadequate nutrition triggers developmental adaptations and adult chronic disease. Maternal high-fat (HF) diet promotes visceral obesity and hypothalamic leptin resistance in male rat offspring at weaning and adulthood. Obesity is related to over active endocannabinoid system (ECS). The ECS consists mainly of endogenous ligands, cannabinoid receptors (CB1 and CB2), and the enzymes fatty acid anandamide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). We hypothesized that perinatal maternal HF diet would regulate offspring ECS in hypothalamus and brown adipose tissue (BAT) at birth, prior to visceral obesity development, and program food preference and energy expenditure of adult offspring...
October 5, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29054611/maternal-undernutrition-during-lactation-alters-nicotine-reward-and-dopac-dopamine-ratio-in-cerebral-cortex-in-adolescent-mice-but-does-not-affect-nicotine-induced-nachrs-upregulation
#10
Ana C Dutra-Tavares, Juliana O Silva, André L Nunes-Freitas, Vinícius M S Guimarães, Ulisses C Araújo, Ellen P S Conceição, Egberto G Moura, Patrícia C Lisboa, Cláudio C Filgueiras, Alex C Manhães, Yael Abreu-Villaça, Anderson Ribeiro-Carvalho
Early undernutrition causes long lasting alterations that affect the response to psychoactive drugs. Particularly, undernutrition during lactation affects the acute locomotor response to nicotine during adolescence, but the reward effect of continued exposure to nicotine remains unknown. The goal of this study was to investigate the effects of undernutrition during lactation on the nicotine susceptibility indexed via conditioned place preference (CPP), on dopamine content and turnover and on nicotine-induced nicotinic cholinergic receptor (nAChR) upregulation in the cerebral cortex, midbrain and hippocampus of adolescent mice...
October 18, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28989878/prevalence-of-metabolic-syndrome-markers-among-women-at-1-year-postpartum-as-per-prepregnancy-body-mass-index-status-a-longitudinal-study
#11
Neha A Kajale, Vaman Khadilkar, Shashi A Chiplonkar, Raja Padidela, Anuradha V Khadilkar
INTRODUCTION: Maternal body composition (BC) changes during lactation. Increased prepregnancy obesity is associated with poor obstetric outcomes. The aim was to study changes in maternal BC postpartum (PP) to 1-year PP with reference to their prepregnancy body mass index (BMI) status. METHODS: The study design was a 1-year follow-up study. Sixty-five apparently healthy primiparous women (28.6 ± 3.4 years delivered full-term infants) were randomly selected from December 2010 to June 2013 and postclassified on the basis of their prepregnancy BMI status...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28859076/developmental-programming-of-somatic-growth-behavior-and-endocannabinoid-metabolism-by-variation-of-early-postnatal-nutrition-in-a-cross-fostering-mouse-model
#12
Felix Schreiner, Merle Ackermann, Michael Michalik, Eva Hucklenbruch-Rother, Andras Bilkei-Gorzo, Ildiko Racz, Laura Bindila, Beat Lutz, Jörg Dötsch, Andreas Zimmer, Joachim Woelfle
BACKGROUND: Nutrient deprivation during early development has been associated with the predisposition to metabolic disorders in adulthood. Considering its interaction with metabolism, appetite and behavior, the endocannabinoid (eCB) system represents a promising target of developmental programming. METHODS: By cross-fostering and variation of litter size, early postnatal nutrition of CB6F1-hybrid mice was controlled during the lactation period (3, 6, or 10 pups/mother)...
2017: PloS One
https://www.readbyqxmd.com/read/28567337/body-mass-index-is-associated-with-region-dependent-metabolic-reprogramming-of-adipose-tissue
#13
Marco G Alves, Ângela Moreira, Marta Guimarães, Mário Nora, Mario Sousa, Pedro F Oliveira, Mariana P Monteiro
Adipose tissue (AT) is involved in dysmetabolism pathogenesis. Regional fat distribution and functioning may contribute to obesity-related metabolic disorders and adverse health outcomes. Specific fat depots are suggested to possess unique biological properties, but specific metabolic profiles of subcutaneous (SAT) and visceral adipose tissue (VAT) remain unknown. We aimed to characterize VAT and SAT glucose metabolism, and their correlation with body mass index (BMI). AT samples from patients (n = 12; F:M, 9:3) with a mean age of 46 years (26-83 years) and an average BMI of 29...
December 2017: BBA Clinical
https://www.readbyqxmd.com/read/28527122/effects-of-cigarette-smoke-exposure-during-suckling-on-food-intake-fat-mass-hormones-and-biochemical-profile-of-young-and-adult-female-rats
#14
Patricia Cristina Lisboa, Patricia Novaes Soares, Thamara Cherem Peixoto, Janaine Cavalcanti Carvalho, Camila Calvino, Vanessa Silva Tavares Rodrigues, Dayse Nascimento Bernardino, Viviane Younes-Rapozo, Alex Christian Manhães, Elaine de Oliveira, Egberto Gaspar de Moura
PURPOSE: Children from smoking mothers have a higher risk of developing obesity and associated comorbidities later in life. Different experimental models have been used to assess the mechanisms involved with this increased risk. Using a rat model of neonatal nicotine exposure via implantation of osmotic minipumps in lactating dams, we have previously shown marked sexual dimorphisms regarding metabolic and endocrine outcomes in the adult progeny. Considering that more than four thousand substances are found in tobacco smoke besides nicotine, we then studied a rat model of neonatal tobacco smoke exposure: adult male offspring had hyperphagia, obesity, hyperglycemia, hypertriglyceridemia, secondary hyperthyroidism and lower adrenal hormones...
July 2017: Endocrine
https://www.readbyqxmd.com/read/28182286/maternal-cinnamon-extract-intake-during-lactation-leads-to-sex-specific-endocrine-modifications-in-rat-offspring
#15
Thais Bento-Bernardes, Fernanda P Toste, Carmen C Pazos-Moura, Karen J Oliveira
BACKGROUND: Cinnamon supplementation has been associated with an improvement in glucose disposal and a reduction in fat mass in type 2 diabetes. Maternal nutrition during lactation impacts the health of the offspring throughout life. We hypothesize that cinnamon intake by lactating rats affects maternal physiology, leading to hormonal and metabolic changes in their offspring. To investigate this hypothesis, dams received aqueous cinnamon extract (400 mg cinnamon kg(-1)  body mass day(-1) ) or water orally, during lactation...
February 9, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28158227/beneficial-effects-of-metformin-on-energy-metabolism-and-visceral-fat-volume-through-a-possible-mechanism-of-fatty-acid-oxidation-in-human-subjects-and-rats
#16
Ichiro Tokubuchi, Yuji Tajiri, Shimpei Iwata, Kento Hara, Nobuhiko Wada, Toshihiko Hashinaga, Hitomi Nakayama, Hiroharu Mifune, Kentaro Yamada
OBJECTIVE: Metformin is known to have a beneficial effect on body weight and body composition, although the precise mechanism has not been elucidated yet. The aim of this study is to investigate the effects of metformin on energy metabolism and anthropometric factors in both human subjects and rats. METHODS: In human studies, metformin (1500mg/day) was administered to 23 healthy subjects and 18 patients with type 2 diabetes for 2 weeks. Metabolic parameters and energy metabolism were measured during a meal tolerance test in the morning before and after the treatment of metformin...
2017: PloS One
https://www.readbyqxmd.com/read/28063476/short-communication-immunohistochemical-localization-of-the-immune-cell-marker-cd68-in-bovine-adipose-tissue-impact-of-tissue-alterations-and-excessive-fat-accumulation-in-dairy-cows
#17
S Häussler, D Germeroth, L Laubenthal, L F Ruda, J Rehage, S Dänicke, H Sauerwein
With the onset of lactation energy from feed intake is mostly insufficient to meet the requirements of dairy cows. Lipid mobilization from adipose tissue (AT) could lead to a compromised inflammatory response enhancing the incidence for diseases. In addition, tissue alterations can occur, displaying areas of necrosis and inflammation. Furthermore, over-conditioned cows mobilizing more lipids from AT than thin cows are prone to develop metabolic disorders. This might lead to an increased infiltration of phagocytic immune cells into AT...
January 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28058732/bromocriptine-treatment-at-the-end-of-lactation-prevents-hyperphagia-higher-visceral-fat-and-liver-triglycerides-in-early-weaned-rats-at-adulthood
#18
Nayara Peixoto-Silva, Egberto G Moura, Janaine C Carvalho, Jéssica L Nobre, Fernanda T Quitete, Cintia R Pinheiro, Ana Paula Santos-Silva, Elaine de Oliveira, Patricia C Lisboa
Non-pharmacological early weaning (NPEW) leads offspring to obesity, higher liver oxidative stress and microsteatosis in adulthood. Pharmacological EW (PEW) by maternal treatment with bromocriptine (BRO) causes obesity in the adult progeny but precludes hepatic injury. To test the hypothesis that BRO prevents the deleterious changes of NPEW, we injected BRO into the pups from the NPEW model in late lactation. Lactating rats were divided into two groups: dams with an adhesive bandage around the body to prevent breastfeeding on the last 3 days of lactation and dams whose pups had free suckling (C)...
April 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27898075/maternal-high-fat-diet-prevents-developmental-programming-by-early-life-stress
#19
M Rincel, A L Lépinay, P Delage, J Fioramonti, V S Théodorou, S Layé, M Darnaudéry
Anxiety disorders and depression are well-documented in subjects exposed to adverse childhood events. Recently, maternal obesity and/or maternal consumption of high-fat diets (HFD) have been also proposed as risk factors for offspring mental health. Here using an animal model in rats, we explored the combinatorial effects of a maternal HFD (40% of energy from fat without impact on maternal weight; during gestation and lactation) and maternal separation (MS) in offspring. In the prefrontal cortex (PFC) of pups, MS led to changes in the expression of several genes such as Bdnf (brain derived neurotrophic factor), 5HT-r1a (serotonin receptor 1a) and Rest4 (neuron-restrictive silencer element, repressor element 1, silencing transcription factor (Rest), splicing variant 4)...
November 29, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27609670/effects-of-ilex-paraguariensis-yerba-mate-on-the-hypothalamic-signalling-of-insulin-and-leptin-and-liver-dysfunction-in-adult-rats-overfed-during-lactation
#20
E P S Conceição, A R Kaezer, N Peixoto-Silva, I Felzenszwalb, E de Oliveira, E G Moura, P C Lisboa
Ilex paraguariensis (yerba mate) has a beneficial effect in the management of obesity. Here, we studied the effects of yerba mate on hypothalamic changes in leptin and insulin signalling, oxidative stress and liver morphology and metabolism in postnatal early overfeeding (EO) Wistar rats. To induce EO, the litter size was reduced to three pups per dam, and litters with 10 pups per dam were used as a control (10 litters each). On postnatal day (PN) 150, EO offspring were subdivided into EO and EO+mate groups (10 animals each), which were treated with water or mate tea [1 g/kg body weight (BW)/day, by gavage], respectively, for 30 days...
February 2017: Journal of Developmental Origins of Health and Disease
keyword
keyword
110613
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"