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"Septic Shock"

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https://www.readbyqxmd.com/read/29923903/pressure-injury-risk-factors-in-critical-care-patients-a-descriptive-analysis
#1
Jill Cox, Sharon Roche, Virginia Murphy
BACKGROUND: Pressure injury (PI) development in the critical care population is multifactorial. Despite the application of evidence-based prevention strategies, PIs do occur and may be unavoidable in some patients. OBJECTIVES: To describe the risk factors associated with PI development in a sample of medical-surgical intensive care unit patients and determine whether these risk factors were congruent with the risk factors proposed in the work of the National Pressure Ulcer Advisory Panel on unavoidable PIs...
July 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29923896/part-iii-minimum-quality-threshold-in-pre-clinical-sepsis-studies-mqtipss-for-fluid-resuscitation-and-antimicrobial-therapy-endpoints
#2
Judith Hellman, Soheyl Bahrami, Mihaly Boros, Irshad Chaudry, Gerhard Fritsch, Waldemar Gozdzik, Shigeaki Inoue, Peter Radermacher, Mervyn Singer, Marcin F Osuchowski, Markus Huber-Lang
As outlined in the "International Guidelines for Management of Sepsis and Septic Shock: 2016", initial fluid resuscitation and administration of antibiotics are key steps in the early management of sepsis and septic shock. However, such clear guidelines do not exist for pre-clinical sepsis models. To address these shortcomings, the Wiggers-Bernard conference on pre-clinical sepsis models was held in Vienna in May, 2017. The participants reviewed 260 of the most highly cited papers between 2003 and 2012 that used sepsis models...
June 19, 2018: Shock
https://www.readbyqxmd.com/read/29921616/study-of-complications-of-varicella-zoster-virus-infection-in-hospitalized-children-at-a-reference-hospital-for-infectious-disease-treatment
#3
Lilian Martins Oliveira Diniz, Marcelle Marie Martins Maia, Yara Vieira de Oliveira, Marina Santos Falci Mourão, Amanda Vieira Couto, Vânia Carneiro Mota, Carolina Mazieiro Versiani, Priscila Olívia da Costa Silveira, Roberta Maia Castro Romanelli
OBJECTIVES: Varicella is a disease with potentially severe complications. We aimed to investigate characteristics of hospitalized children with varicella in Brazil in the prevaccine period and to identify predictors for requiring intensive care treatment. METHODS: A prospective cohort study was conducted from May 2011 to April 2014. Patients up to 13 years of age with varicella diagnosis were included. Information was collected through interview and review of medical records...
June 19, 2018: Hospital Pediatrics
https://www.readbyqxmd.com/read/29921471/rethinking-the-concept-of-sepsis-and-septic-shock
#4
REVIEW
Joana A Cabrita, Isabel Pinheiro, L Menezes Falcão
Sepsis is a major global health problem and represents a challenge for physicians all over the world. The knowledge of sepsis and septic shock is a topic of interest among the scientific community and society in general. New guidelines for management of sepsis and septic shock were developed in 2016, providing an update on this area. In Sepsis-3 new definitions for sepsis and septic shock were published. The purpose of this narrative review is to discuss and compare the new criteria of 2016 with the old criteria, purposing at the same time an alternative approach for this topic...
June 16, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29921214/sepsis-the-involvement-of-platelets-and-the-current-treatments
#5
Ana Carolina Antunes Naime, Jessica Oliveira Frade Ganaes, Maria Elisa Lopes-Pires
OBJECTIVE: Sepsis, a serious and life threatening complication arising from infection caused by lipopolysaccharide, is a complex inflammatory syndrome, and one of the main causes of death in intensive care units (ICU). It is characterized as an over-response of pro-coagulant agents promotes coagulopathy and thrombus formation, resulting in disseminated intravascular coagulation (DIC). Furthermore, it can cause multiple organ dysfunction and hypotension (septic shock) resulting in death...
June 19, 2018: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/29916971/cervicofacial-necrotizing-fasciitis-and-drugs
#6
Laís Sara Egas, Erik Neiva Ribeiro de Carvalho Reis, Leonardo Freitas da Silva, João Paulo Bonardi, Valthierre Nunes de Lima, Pedro Henrique Silva Gomes Ferreira, Ciro Borges Duailibe de Deus, Idelmo Rangel Garcia Júnior
Necrotizing fasciitis (NF) is a devastating disease that typically affects immunocompromised patients, chronically debilitated patients or drug users, but can also affect healthy patients. Necrotizing fasciitis can rapidly produce septic shock and requires immediate surgical management of the necrotic tissue. It is a bacterial infection that progresses rapidly and has a high mortality generally caused by aerobic and anaerobic bacteria. The patient was immunocompromised and drug user. During treatment, a combination of broad-spectrum antibiotic therapy with Ciprofloxacin and Metronidazole, besides the use of activated charcoal dressing composed of carbonized fabric and impregnated with 0...
June 18, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29916359/hepatic-abscess-induced-by-fish-bone-migration-two-case-reports
#7
José Eduardo Mateus, Carlos Silva, Sofia Beirão, Jorge Pimentel
Although foreign body ingestion is a common occurrence, perforation and penetration of the gastrointestinal tract is unusual and the development of a hepatic abscess is even more rare. The authors describe two cases of fish bone perforation of the gastrointestinal tract with hepatic perforation and abscess formation, from distinctive age groups and varying presentation, although both developed septic shock. The lack of history of ingestion of foreign bodies, non-specificity of both clinical presentation and complementary examinations all play a role in delaying the diagnosis and therefore in the prognosis itself...
May 30, 2018: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29916105/synergistic-effects-of-perioperative-complications-on-30-day-mortality-following-hepatopancreatic-surgery
#8
Katiuscha Merath, Qinyu Chen, Fabio Bagante, Ozgur Akgul, Jay J Idrees, Mary Dillhoff, Jordan M Cloyd, Timothy M Pawlik
BACKGROUND: Data on the interaction effect of multiple concurrent postoperative complications relative to the risk of short-term mortality following hepatopancreatic surgery have not been reported. The objective of the current study was to define the interaction effect of postoperative complications among patients undergoing HP surgery on 30-day mortality. METHODS: Using the ACS-NSQIP Procedure Targeted Participant Use Data File, patients who underwent HP surgery between 2014 and 2016 were identified...
June 18, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29914246/role-of-hepcidin-in-the-diagnosis-of-sepsis-and-septic-shock-in-children
#9
Osman Yeşilbaş, Esra Şevketoğlu, Burcu Bursal Duramaz, Hasan Serdar Kıhtır, Asuman Gedikbaşı, Mey Talip Petmezci, Canan Baydemir
Background/aim: The purpose of this study is to compare the diagnostic value of hepcidin level with the white blood cell (WBC), C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) levels in pediatric sepsis and septic shock. Materials and methods: A cohort of 89 individuals were divided into four groups: a healthy control group (HCG, n = 28), pediatric intensive care unit control group (PICUCG, n = 17), sepsis group (SG, n = 23), and septic shock group (SSG, n = 21). WBC, CRP, PCT, IL-6, and hepcidin levels were studied in the PICUCG, SG, and SSG, while hepcidin and IL-6 levels were studied in the HCG...
June 14, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29913494/hydrocortisone-did-not-reduce-mortality-at-90-days-in-patients-with-septic-shock
#10
Brent A Duran, Robert G Badgett, Steven Q Simpson
No abstract text is available yet for this article.
June 19, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29913493/hydrocortisone-plus-fludrocortisone-reduced-mortality-at-90-days-in-patients-with-septic-shock
#11
Brent A Duran, Robert G Badgett, Steven Q Simpson
No abstract text is available yet for this article.
June 19, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29912769/factors-related-to-surgical-treatment-and-outcomes-of-thai-patients-with-septic-arthritis
#12
Chonlada Ruangpin, Muchima Rodchuae, Wanruchada Katchamart
OBJECTIVE: The aim of this study was to identify factors associated with the surgical treatment of Thai patients with septic arthritis. METHODS: This retrospective cohort study used a university hospital database in Thailand to identify 450 adult patients with confirmed septic arthritis. Data related to baseline characteristics, clinical and laboratory findings, treatment, and outcomes were collected. A multivariate analysis identified the factors related to surgical treatment...
June 15, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29912250/-lethality-analysis-in-patients-with-tuberculosis-diagnosis-in-a-high-complexity-hospital-in-cali-colombia
#13
M Alexandra Sánchez, Jessica Pino, Robinson Pacheco, José Fernando García
Background In 2016 tuberculosis (TB) was considered the ninth leading cause of death worldwide and the leading cause of a single infectious agent, with approximately 1.6 million deaths worldwide and a lethality of 15%. Over 95% of cases and deaths are in developing countries like Colombia. AIM: To describe the sociodemographic and clinical characteristics of patients who died during TB treatment in a high complexity hospital in Cali, Colombia. METHODS: We conducted an analytic retrospective cohort during 2007-2016 in Fundación Valle del Lili...
April 2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29911468/do-low-dose-corticosteroids-improve-survival-or-shock-reversal-from-septic-shock-in-adults-meta-analysis-with-trial-sequential-analysis
#14
Rui Xu, Qian Wang, Yan Huang, Ling Wu, Qi Liu, Wei Hu, Chengfu Zhou, Quan Du
Objective This meta-analysis with trial sequential analysis (TSA) was performed to determine whether low-dose corticosteroids (LDCs) can improve survival or shock reversal from septic shock in adults. Methods A literature search was performed using several databases (Medline, Cochrane Library, Embase, and Chinese Biological Medical Database) until 23 October 2017. The systematic review was registered in PROSPERO. Results Nine randomized controlled trials (RCTs) (n = 1182) were included. LDC intervention improved 7-day shock reversal compared with the control group (relative risk, 1...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29907130/acute-kidney-injury-is-associated-with-a-decrease-in-cortical-renal-perfusion-during-septic-shock
#15
Anatole Harrois, Nicolas Grillot, Samy Figueiredo, Jacques Duranteau
BACKGROUND: Renal perfusion status remains poorly studied at the bedside during septic shock. We sought to measure cortical renal perfusion in patients with septic shock during their first 3 days of care using renal contrast enhanced ultrasound (CEUS). METHODS: We prospectively included 20 ICU patients with septic shock and 10 control patients (CL) without septic shock admitted to a surgical ICU. Cortical renal perfusion was evaluated with CEUS during continuous infusion of Sonovue (Milan, Italy) within the first 24 h (day 0), between 24 and 48 h (day 1) and after 72 h (day 3) of care...
June 15, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29907107/complete-abdominal-wound-and-anastomotic-leak-with-diffuse-peritonitis-closure-achieved-by-an-abdominal-vacuum-sealing-drainage-in-a-critical-ill-patient-a-case-report
#16
Yusuke Fujii, Yoshitsugu Tajima, Shunsuke Kaji, Takashi Kishi, Yoshiko Miyazaki, Takahito Taniura, Noriyuki Hirahara
BACKGROUND: Negative pressure wound therapy (NPWT) is a widely accepted technique to treat local infectious wounds of the skin, subcutaneous tissue, fascia, or muscle. Recently, several reports describing the efficacy of NPWT for various types of fistulas and anastomotic leaks have been published. We herein describe a patient with an open abdominal wound due to colonic anastomotic leakage and diffuse peritonitis, in whom abdominal vacuum sealing (AVS) as a modified NPWT was useful for the management of this complex wound...
June 15, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29906560/erythrocyte-sod1-activity-but-not-sod1-polymorphisms-is-associated-with-icu-mortality-in-patients-with-septic-shock
#17
Nara Aline Costa, Natália Baraldi Cunha, Ana Lucia Gut, Paula Schmidt Azevedo, Bertha Furlan Polegato, Leonardo Antonio Mamede Zornoff, Sergio Alberto Rupp de Paiva, Bruna Zavarize Reis, Ana Angelica Henrique Fernandes, Marcelo Macedo Rogero, Marina Maintinguer Norde, Marcos Ferreira Minicucci
The objective of our study was to evaluate the influence of the superoxide dismutase 1 (SOD1) polymorphisms on erythrocyte SOD1 activity and the mortality of patients with septic shock.We prospectively evaluated 175 patients aged over 18 years with septic shock upon ICU admission. However, 38 patients were excluded. Thus, 137 patients were enrolled in the study. Blood samples were taken within the first 24hours of the patient's admission to determine erythrocyte SOD1 activity and nine SOD1 gene polymorphisms...
June 12, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29905672/alterations-in-mitochondrial-function-in-blood-cells-obtained-from-patients-with-sepsis-presenting-to-an-emergency-department
#18
David H Jang, Clinton J Orloski, Shawn Owiredu, Frances S Shofer, John C Greenwood, David M Eckmann
OBJECTIVE: Mitochondrial dysfunction has been implicated as a key cellular event leading to organ dysfunction in sepsis. Our objective is to measure changes in mitochondrial bioenergetics in subjects with early presentation of sepsis to provide insight into the incompletely understood pathophysiology of the dysregulated host response in sepsis. DESIGN: Prospective observational study SETTING:: Single site tertiary academic emergency department SUBJECTS:: We enrolled a total of 48 subjects were enrolled in the study, 10 with sepsis or septic shock, 10 with infection without sepsis, 14 older and 14 younger healthy controls...
June 13, 2018: Shock
https://www.readbyqxmd.com/read/29905549/recent-principles-of-antimicrobial-treatment-in-polytrauma-induced-sepsis-and-septic-shock-review
#19
B Kanashvili, Kh Saganelidze, L Ratiani
20% of trauma deaths occur late after the injury. It is usually the result of sepsis, multi-system organ failure, or other complications. In Polytrauma induced sepsis and septic shock patients, antibacterial management is crucial. The knowledge of recent aspects of treatment is decreasing the costs and the resistance of pathogens, morbidity and mortality. Different models of treatment are suggested by authors, basically they are depended on: the patients age, there health condition, the factors of immunodeficiency, at the location of infection and others...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29905091/refractory-hyperlactatemia-after-a-septic-shock-in-a-patient-with-carnitine-deficiency-a-case-report
#20
Philippe Hogan, Roxane Plourde, Maude Fortier, Dave Brindamour, Colin Lagrenade-Verdant, Simon Demers-Marcil, Sébastien Dupuis
A 56-year-old woman with septic shock presented with persistent hyperlactatemia, despite an adequate clinical response to treatment. Carnitine deficiency was suspected, as the patient was malnourished and chronically taking valproic acid. No other plausible cause of hyperlactatemia was found. Carnitine supplementation resulted in rapid normalization of lactatemia.
January 1, 2018: Journal of Pharmacy Practice
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