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Atrial fibrilliation

Antonio Pacifico, Philip D Henry
Atrial fibrilliation (AF) is often combined with advanced age and structural heart disease, conditions known to invite serious proarrhythmic complications of antiarrhythmic drug therapy. Recent controlled trials comparing two AF treatment strategies-rhythm control requiring atrial defibrilliation and antiarrhythmic drugs to prevent AF and ventiricular rate control obviating sinus rhythm maintenance with such drugs-showed equal or superior results with rate control. AF is associated with derepressions of "fetospecific" expression patterns that may profoundly alter the responsiveness of atrial muscle to antiarrhythmic drugs...
July 2003: Pacing and Clinical Electrophysiology: PACE
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