keyword
https://read.qxmd.com/read/37714636/is-axillary-staging-obsolete-in-early-breast-cancer
#21
REVIEW
Monica Morrow
This article reviews the incidence of nodal metastases in early-stage breast cancer and the need for axillary staging to maintain local control in the axilla or to determine the need for adjuvant systemic therapy across the spectrum of patients with breast cancer, and reviews clinical trials addressing this question. At present, sentinel lymph node biopsy should be omitted in women age ≥70 years with cT1-2 N0, HR+/HER2- cancers. The importance of nodal status in selecting patients for radiotherapy remains the main reason for axillary staging in younger postmenopausal women with cT1-2N0, HR+/HER2- cancers...
October 2023: Surgical Oncology Clinics of North America
https://read.qxmd.com/read/37658275/aso-visual-abstract-satisfaction-and-well-being-after-contralateral-prophylactic-mastectomy-among-brca-mutation-carriers-and-noncarriers-a-longitudinal-analysis-of-breast-q-domains
#22
JOURNAL ARTICLE
Sara P Myers, Audree B Tadros, Varadan Sevilimedu, Jonas A Nelson, Tiana Le, Paula Garcia, Monica Morrow, Minna K Lee
No abstract text is available yet for this article.
September 1, 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/37581851/satisfaction-and-well-being-after-contralateral-prophylactic-mastectomy-among-brca-mutation-carriers-and-noncarriers-a-longitudinal-analysis-of-breast-q-domains
#23
JOURNAL ARTICLE
Sara P Myers, Audree B Tadros, Varadan Sevilimedu, Jonas A Nelson, Tiana Le, Paula Garcia, Monica Morrow, Minna K Lee
INTRODUCTION: Contralateral prophylactic mastectomy (CPM) is recommended for BRCA mutation carriers; its use in noncarriers relies on patient choice. We characterized differences in satisfaction and well-being after CPM between BRCA carriers and noncarriers. METHODS: BREAST-Q data were obtained before and after CPM with immediate reconstruction performed at a single institution from 2016 to 2022. Associations between BRCA status and satisfaction with breasts, psychosocial well-being, and sexual well-being were assessed, with adjustment for preoperative scores and relevant confounders...
August 15, 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/37493892/does-non-classic-lobular-carcinoma-in-situ-at-the-lumpectomy-margin-increase-local-recurrence
#24
JOURNAL ARTICLE
Anna C Beck, Solange Bayard, George Plitas, Varadan Sevilimedu, M Gabriela Kuba, Paula Garcia, Monica Morrow, Audree B Tadros
BACKGROUND: The clinical significance of nonclassic, lobular carcinoma in situ (NC-LCIS) at the surgical margin of excisions for invasive cancer is unknown. We sought to determine whether NC-LCIS at or near the margin in the setting of a concurrent invasive carcinoma is associated with risk of ipsilateral breast tumor recurrence (IBTR) and locoregional recurrence (LRR). METHODS: Patients with stage 0-III breast cancer and NC-LCIS who underwent lumpectomy between January 2010 and January 2022 at a single institution were retrospectively identified...
October 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/37178195/strategies-to-avoid-mastectomy-skin-flap-necrosis-during-nipple-sparing-mastectomy
#25
JOURNAL ARTICLE
Tracy-Ann Moo, Jonas A Nelson, Varadan Sevilimedu, Jillian Charyn, Tiana V Le, Robert J Allen, Babak J Mehrara, Andrea V Barrio, Deborah M Capko, Melissa Pilewskie, Alexandra S Heerdt, Audree B Tadros, Mary L Gemignani, Monica Morrow, Virgilio Sacchini
BACKGROUND: Nipple-sparing mastectomy is associated with a higher risk of mastectomy skin-flap necrosis than conventional skin-sparing mastectomy. There are limited prospective data examining modifiable intraoperative factors that contribute to skin-flap necrosis after nipple-sparing mastectomy. METHODS: Data on consecutive patients undergoing nipple-sparing mastectomy between April 2018 and December 2020 were recorded prospectively. Relevant intraoperative variables were documented by both breast and plastic surgeons at the time of surgery...
June 12, 2023: British Journal of Surgery
https://read.qxmd.com/read/37157868/burden-of-respiratory-viruses-in-children-less-than-2-years-old-in-a-community-based-longitudinal-us-birth-cohort
#26
JOURNAL ARTICLE
Zheyi Teoh, Shannon Conrey, Monica McNeal, Allison Burrell, Rachel M Burke, Claire Mattison, Meredith McMorrow, Daniel C Payne, Ardythe L Morrow, Mary Allen Staat
BACKGROUND: Respiratory viral infections are a major cause of morbidity and hospitalization in young children. Nevertheless, the population burden of respiratory viral infections, especially asymptomatic cases, is not known due to the lack of prospective community-based cohort studies with intensive monitoring. METHODS: To address this gap, we enacted the PREVAIL cohort, a Centers for Disease Control and Prevention-sponsored birth cohort in Cincinnati, Ohio, where children were followed from 0 to 2 years of age...
September 18, 2023: Clinical Infectious Diseases
https://read.qxmd.com/read/37126938/uncertainties-and-controversies-in-axillary-management-of-patients-with-breast-cancer
#27
REVIEW
Walter P Weber, Oreste Davide Gentilini, Monica Morrow, Giacomo Montagna, Jana de Boniface, Florian Fitzal, Lynda Wyld, Isabel T Rubio, Zoltan Matrai, Tari A King, Ramon Saccilotto, Viviana Galimberti, Nadia Maggi, Mariacarla Andreozzi, Virgilio Sacchini, Liliana Castrezana López, Julie Loesch, Fabienne D Schwab, Ruth Eller, Martin Heidinger, Martin Haug, Christian Kurzeder, Rosa Di Micco, Maggie Banys-Paluchowski, Nina Ditsch, Yves Harder, Régis R Paulinelli, Cicero Urban, John Benson, Vesna Bjelic-Radisic, Shelley Potter, Michael Knauer, Marc Thill, Marie-Jeanne Vrancken Peeters, Sherko Kuemmel, Joerg Heil, Bahadir M Gulluoglu, Christoph Tausch, Ursula Ganz-Blaettler, Jane Shaw, Peter Dubsky, Philip Poortmans, Orit Kaidar-Person, Thorsten Kühn, Michael Gnant
The aims of this Oncoplastic Breast Consortium and European Breast Cancer Research Association of Surgical Trialists initiative were to identify uncertainties and controversies in axillary management of early breast cancer and to recommend appropriate strategies to address them. By use of Delphi methods, 15 questions were prioritized by more than 250 breast surgeons, patient advocates and radiation oncologists from 60 countries. Subsequently, a global virtual consensus panel considered available data, ongoing studies and resource utilization...
June 2023: Cancer Treatment Reviews
https://read.qxmd.com/read/37099089/aso-visual-abstract-interpreting-the-breast-q-for-breast-conserving-therapy-minimal-important-differences-and-clinical-reference-values
#28
JOURNAL ARTICLE
Jacqueline J Chu, Audree B Tadros, Lucas Gallo, Babak J Mehrara, Monica Morrow, Andrea L Pusic, Sophocles H Voineskos, Jonas A Nelson
No abstract text is available yet for this article.
April 26, 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/37022571/aso-visual-abstract-is-surgical-excision-of-focal-atypical-ductal-hyperplasia-warranted-experience-at-a-tertiary-care-center
#29
JOURNAL ARTICLE
Anne Grabenstetter, Sandra B Brennan, Varadan Sevilimedu, M Gabriela Kuba, Dilip D Giri, Hannah Yong Wen, Monica Morrow, Edi Brogi
No abstract text is available yet for this article.
April 6, 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/36989453/comparing-the-burden-of-illness-in-patients-with-alopecia-areata-vs-atopic-dermatitis-in-the-us-population-from-a-payer-perspective
#30
JOURNAL ARTICLE
D Christian Fenske, Yuxin Ding, Paula Morrow, Sarah G Smith, Monica K Silver, Meghan Moynihan, Janna Manjelievskaia
BACKGROUND: Alopecia areata (AA) is an autoimmune disease characterized by nonscarring hair loss. AA frequently co-occurs with other inflammatory autoimmune conditions, presenting a significant clinical burden. OBJECTIVE: To compare the burden of illness, direct and indirect costs in adult patients with AA vs atopic dermatitis (AD). METHODS: This retrospective cohort study used US administrative claims data from the Merative MarketScan Commercial Claims and Encounters Database to compare commercially insured adults with AA to those with AD...
April 2023: Journal of Managed Care & Specialty Pharmacy
https://read.qxmd.com/read/36920589/aso-visual-abstract-timing-of-chemotherapy-and-patient-reported-outcomes-after-breast-conserving-surgery-and-mastectomy-with-immediate-reconstruction
#31
JOURNAL ARTICLE
Kate R Pawloski, Marissa K Srour, Tracy-Ann Moo, Varadan Sevilimedu, Jonas A Nelson, Paula Garcia, Laurie J Kirstein, Monica Morrow, Audree B Tadros
No abstract text is available yet for this article.
May 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/36915277/increasing-rates-of-general-anesthesia-use-in-lumpectomy-procedures-a-15-year-trends-analysis
#32
JOURNAL ARTICLE
Robyn N Rubenstein, Audree Tadros, Hanna L Slutsky, Ethan L Plotsker, Kathryn Haglich, Carrie S Stern, Monica Morrow, Jonas A Nelson, Priscilla Nelson
BACKGROUND: Anesthesia methods in oncologic breast surgery have evolved with less invasive practices. The aims of this study were primarily to examine trends in anesthesia type used during lumpectomy. METHODS: We analyzed lumpectomy procedures from 2005 to 2019 using the NSQIP database. Upon defining the nadir in general anesthesia (GA) and peak in monitored anesthesia care (MAC) use as 2007, we compared patient characteristics and complications in the 2007 versus 2019 GA and MAC cohorts...
March 13, 2023: Journal of Surgical Oncology
https://read.qxmd.com/read/36905438/is-surgical-excision-of-focal-atypical-ductal-hyperplasia-warranted-experience-at-a-tertiary-care-center
#33
JOURNAL ARTICLE
Anne Grabenstetter, Sandra B Brennan, Varadan Sevilimedu, M Gabriela Kuba, Dilip D Giri, Hannah Yong Wen, Monica Morrow, Edi Brogi
BACKGROUND: The core-needle biopsy (CNB) diagnosis of atypical ductal hyperplasia (ADH) generally mandates follow-up excision, but controversy exists on whether small foci of ADH require surgical management. This study evaluated the upgrade rate at excision of focal ADH (fADH), defined as 1 focus spanning ≤ 2 mm. METHODS: We retrospectively identified in-house CNBs with ADH as the highest-risk lesion obtained between January 2013 and December 2017...
July 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/36840864/interpreting-the-breast-q-for-breast-conserving-therapy-minimal-important-differences-and-clinical-reference-values
#34
JOURNAL ARTICLE
Jacqueline J Chu, Audree B Tadros, Lucas Gallo, Babak J Mehrara, Monica Morrow, Andrea L Pusic, Sophocles H Voineskos, Jonas A Nelson
BACKGROUND: The BREAST-Q is an important tool for evaluating patient satisfaction and quality of life in breast-conserving therapy (BCT) patients, but its clinical utility is limited by the lack of guidance on score interpretation. This study determines reference values and the minimal important difference (MID) for the BREAST-Q BCT module. METHODS: A retrospective review of BCT patients at Memorial Sloan Kettering Cancer Center from January 2011 to December 2021 was performed...
February 25, 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/36812344/obesity-promotes-breast-epithelium-dna-damage-in-women-carrying-a-germline-mutation-in-brca1-or-brca2
#35
JOURNAL ARTICLE
Priya Bhardwaj, Neil M Iyengar, Heba Zahid, Katharine M Carter, Dong Jun Byun, Man Ho Choi, Qi Sun, Oleksandr Savenkov, Charalambia Louka, Catherine Liu, Phoebe Piloco, Monica Acosta, Rohan Bareja, Olivier Elemento, Miguel Foronda, Lukas E Dow, Sofya Oshchepkova, Dilip D Giri, Michael Pollak, Xi Kathy Zhou, Benjamin D Hopkins, Ashley M Laughney, Melissa K Frey, Lora Hedrick Ellenson, Monica Morrow, Jason A Spector, Lewis C Cantley, Kristy A Brown
Obesity, defined as a body mass index (BMI) ≥ 30, is an established risk factor for breast cancer among women in the general population after menopause. Whether elevated BMI is a risk factor for women with a germline mutation in BRCA1 or BRCA2 is less clear because of inconsistent findings from epidemiological studies and a lack of mechanistic studies in this population. Here, we show that DNA damage in normal breast epithelia of women carrying a BRCA mutation is positively correlated with BMI and with biomarkers of metabolic dysfunction...
February 22, 2023: Science Translational Medicine
https://read.qxmd.com/read/36812311/biomineralogical-signatures-of-breast-microcalcifications
#36
JOURNAL ARTICLE
Jennie A M R Kunitake, Daniel Sudilovsky, Lynn M Johnson, Hyun-Chae Loh, Siyoung Choi, Patrick G Morris, Maxine S Jochelson, Neil M Iyengar, Monica Morrow, Admir Masic, Claudia Fischbach, Lara A Estroff
Microcalcifications, primarily biogenic apatite, occur in cancerous and benign breast pathologies and are key mammographic indicators. Outside the clinic, numerous microcalcification compositional metrics (e.g., carbonate and metal content) are linked to malignancy, yet microcalcification formation is dependent on microenvironmental conditions, which are notoriously heterogeneous in breast cancer. We interrogate multiscale heterogeneity in 93 calcifications from 21 breast cancer patients using an omics-inspired approach: For each microcalcification, we define a "biomineralogical signature" combining metrics derived from Raman microscopy and energy-dispersive spectroscopy...
February 22, 2023: Science Advances
https://read.qxmd.com/read/36737530/timing-of-chemotherapy-and-patient-reported-outcomes-after-breast-conserving-surgery-and-mastectomy-with-immediate-reconstruction
#37
JOURNAL ARTICLE
Kate R Pawloski, Marissa K Srour, Tracy-Ann Moo, Varadan Sevilimedu, Jonas A Nelson, Paula Garcia, Laurie J Kirstein, Monica Morrow, Audree B Tadros
INTRODUCTION: Receipt of chemotherapy is associated with decreased satisfaction after breast surgery, but whether timing as adjuvant versus neoadjuvant (NAC) affects patient-reported outcomes (PROs) is unclear. We examined associations between chemotherapy timing and PROs after breast-conserving surgery (BCS) and mastectomy with immediate reconstruction (M-IR). METHODS: In this retrospective cohort study of patients with stage I-III breast cancer undergoing chemotherapy between January 2017 and December 2019, we compared satisfaction with breasts (SABTR) and chest physical well-being (PWB-CHEST) between chemotherapy groups in BCS and M-IR cohorts...
February 3, 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/36702672/axillary-lymph-node-dissection-dead-or-still-alive
#38
JOURNAL ARTICLE
Anna C Beck, Monica Morrow
Although sentinel lymph node biopsy is now the primary method of axillary staging and is therapeutic for patients with limited nodal disease, axillary lymph node dissection (ALND) is still necessary for staging in groups where sentinel lymph node biopsy has not been proven to be accurate and to maintain local control in those with a heavy axillary tumor burden. Additionally, newer approaches to systemic therapy tailored to risk level sometimes necessitate knowledge of the number of involved axillary nodes which can only be obtained with ALND...
June 2023: Breast: Official Journal of the European Society of Mastology
https://read.qxmd.com/read/36638314/changes-in-the-diagnoses-of-breast-core-needle-biopsies-on-second-review-at-a-tertiary-care-center-implications-for-surgical-management
#39
JOURNAL ARTICLE
Catarina Calle, Elaine Zhong, Matthew G Hanna, Katia Ventura, Maria A Friedlander, Monica Morrow, Hiram Cody, Edi Brogi
Core needle biopsy (CNB) of breast lesions is routine for diagnosis and treatment planning. Despite refinement of diagnostic criteria, the diagnosis of breast lesions on CNB can be challenging. At many centers, including ours, confirmation of diagnoses rendered in other laboratories is required before treatment planning. We identified CNBs first diagnosed elsewhere that were reviewed in our department over the course of 1 year because the patients sought care at our center and in which a change in diagnosis had been recorded...
February 1, 2023: American Journal of Surgical Pathology
https://read.qxmd.com/read/36483067/the-effect-of-surgeon-referral-and-a-radiation-oncologist-productivity-based-metric-on-radiation-therapy-receipt-among-elderly-women-with-early-stage-breast-cancer-analysis-from-a-tertiary-cancer-network
#40
JOURNAL ARTICLE
Elaine E Cha, Mira A Patel, Y Helen Zhang, Stephanie Lobaugh, Zhigang Zhang, Beryl McCormick, Lior Z Braunstein, Oren Cahlon, Simon N Powell, Monica Morrow, Atif Khan, Erin F Gillespie
PURPOSE: : Guidelines for early-stage breast cancer allow for radiation therapy (RT) omission after breast conserving surgery among older women, though high utilization of RT persists. This study explored surgeon referral and the effect of a productivity-based bonus metric for radiation oncologists in an academic institution with centralized quality assurance review. METHODS AND MATERIALS: : We evaluated patients ≥70 years of age treated with breast conserving surgery for estrogen receptor (ER)+ pT1N0 breast cancer at a single tertiary cancer network between 2015 and 2018...
2023: Advances in Radiation Oncology
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