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https://www.readbyqxmd.com/read/28589366/meta-analysis-of-pre-operative-magnetic-resonance-imaging-mri-and-surgical-treatment-for-breast-cancer
#1
REVIEW
Nehmat Houssami, Robin M Turner, Monica Morrow
BACKGROUND: Although there is no consensus on whether pre-operative MRI in women with breast cancer (BC) benefits surgical treatment, MRI continues to be used pre-operatively in practice. This meta-analysis examines the association between pre-operative MRI and surgical outcomes in BC. METHODS: A systematic review was performed to identify studies reporting quantitative data on pre-operative MRI and surgical outcomes (without restriction by type of surgery received or type of BC) and using a controlled design...
June 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28586788/trends-in-reoperation-after-initial-lumpectomy-for-breast-cancer-addressing-overtreatment-in-surgical-management
#2
Monica Morrow, Paul Abrahamse, Timothy P Hofer, Kevin C Ward, Ann S Hamilton, Allison W Kurian, Steven J Katz, Reshma Jagsi
Importance: Surgery after initial lumpectomy to obtain more widely clear margins is common and may lead to mastectomy. Objective: To describe surgeons' approach to surgical margins for invasive breast cancer, and changes in postlumpectomy surgery rates, and final surgical treatment following a 2014 consensus statement endorsing a margin of "no ink on tumor." Design, Setting, and Participants: This was a population-based cohort survey study of 7303 eligible women ages 20 to 79 years with stage I and II breast cancer diagnosed in 2013 to 2015 and identified from the Georgia and Los Angeles County, California, Surveillance, Epidemiology, and End Results registries...
June 5, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28577081/the-21-gene-recurrence-score-in-special-histologic-subtypes-of-breast-cancer-with-favorable-prognosis
#3
Gulisa Turashvili, Edi Brogi, Monica Morrow, Clifford Hudis, Maura Dickler, Larry Norton, Hannah Y Wen
BACKGROUND/PURPOSE: The 21-gene recurrence score (RS) assay predicts the likelihood of distant recurrence and chemotherapy benefit in early-stage, estrogen receptor (ER)-positive, HER2-negative breast cancer. Data on the RS of special histologic subtypes of invasive breast carcinoma with favorable prognosis are limited. METHODS: We reviewed our institutional database to identify patients with special histologic subtypes of breast cancer associated with favorable prognosis and available RS results...
June 3, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28560596/standard-pathologic-features-can-be-used-to-identify-a-subset-of-estrogen-receptor-positive-her2-negative-patients-likely-to-benefit-from-neoadjuvant-chemotherapy
#4
Oriana A Petruolo, Melissa Pilewskie, Sujata Patil, Andrea V Barrio, Michelle Stempel, Hannah Y Wen, Monica Morrow
BACKGROUND: The benefit of neoadjuvant chemotherapy (NAC) in patients with estrogen receptor-positive (ER+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancers and in invasive lobular carcinoma (ILC) is uncertain due to the low rates of pathologic complete response (pCR). OBJECTIVE: The aim of this study was to determine if pathologic features can identify subsets likely to benefit from NAC. METHODS: Patients with stage I-III ER+, HER2- breast cancer receiving NAC were retrospectively reviewed...
May 30, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28429197/axillary-micrometastases-and-isolated-tumor-cells-are-not-an-indication-for-post-mastectomy-radiotherapy-in-stage-1-and-2-breast-cancer
#5
Anita Mamtani, Sujata Patil, Michelle Stempel, Monica Morrow
BACKGROUND: Randomized trials demonstrate equivalent locoregional control with sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND) for T1-2 micrometastatic breast cancer, but include few mastectomy patients. Consensus is lacking on indications for post-mastectomy radiotherapy (PMRT) in this population. Herein, we evaluate locoregional recurrence (LRR) in an unselected, modern cohort of T1-2 breast cancer patients with micrometastases or isolated tumor cells (ITCs; N0i+/N1mi) having a mastectomy...
April 20, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28423143/leveraging-the-benefits-of-systemic-therapy-to-tailor-surgery
#6
Monica Morrow
No abstract text is available yet for this article.
April 19, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28408715/postoperative-infection-in-developing-world-congenital-heart-surgery-programs-data-from-the-international-quality-improvement-collaborative
#7
Amitabh Chanchal Sen, Debra Forbes Morrow, Rakhi Balachandran, Xinwei Du, Kimberlee Gauvreau, Byalal R Jagannath, Raman Krishna Kumar, Jennifer Koch Kupiec, Monica L Melgar, Nguyen Tran Chau, Gail Potter-Bynoe, Orlando Tamariz-Cruz, Kathy J Jenkins
BACKGROUND: Postoperative infections contribute substantially to morbidity and mortality after congenital heart disease surgery and are often preventable. We sought to identify risk factors for postoperative infection and the impact on outcomes after congenital heart surgery, using data from the International Quality Improvement Collaborative for Congenital Heart Surgery in Developing World Countries. METHODS AND RESULTS: Pediatric cardiac surgical cases performed between 2010 and 2012 at 27 participating sites in 16 developing countries were included...
April 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28402748/gaps-in-incorporating-germline-genetic-testing-into-treatment-decision-making-for-early-stage-breast-cancer
#8
Allison W Kurian, Yun Li, Ann S Hamilton, Kevin C Ward, Sarah T Hawley, Monica Morrow, M Chandler McLeod, Reshma Jagsi, Steven J Katz
Purpose Genetic testing for breast cancer risk is evolving rapidly, with growing use of multiple-gene panels that can yield uncertain results. However, little is known about the context of such testing or its impact on treatment. Methods A population-based sample of patients with breast cancer diagnosed in 2014 to 2015 and identified by two SEER registries (Georgia and Los Angeles) were surveyed about genetic testing experiences (N = 3,672; response rate, 68%). Responses were merged with SEER data. A patient subgroup at higher pretest risk of pathogenic mutation carriage was defined according to genetic testing guidelines...
April 12, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28384687/patient-reactions-to-surgeon-recommendations-about-contralateral-prophylactic-mastectomy-for-treatment-of-breast-cancer
#9
Steven J Katz, Nancy K Janz, Paul Abrahamse, Lauren P Wallner, Sarah T Hawley, Lawrence C An, Kevin C Ward, Ann S Hamilton, Monica Morrow, Reshma Jagsi
Importance: Guidelines assert that contralateral prophylactic mastectomy (CPM) should be discouraged in patients without an elevated risk for a second primary breast cancer. However, little is known about the impact of surgeons discouraging CPM on patient care satisfaction or decisions to seek treatment from another clinician. Objective: To examine the association between patient report of first-surgeon recommendation against CPM and the extent of discussion about it with 3 outcomes: patient satisfaction with surgery decisions, receipt of a second opinion, and receipt of surgery by a second surgeon...
April 5, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28376199/refining-risk-assessment-in-women-with-benign-breast-disease-an-ongoing-dilemma
#10
Stuart J Schnitt, Monica Morrow, Nadine M Tung
No abstract text is available yet for this article.
October 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28334423/are-there-patients-with-t1-to-t2-lymph-node-negative-breast-cancer-who-are-high-risk-for-locoregional-disease-recurrence
#11
Anita Mamtani, Sujata Patil, Michelle M Stempel, Monica Morrow
BACKGROUND: Indications for postmastectomy radiotherapy (PMRT) in patients with T1 to T2, lymph node-negative (N0) breast cancer with "high-risk" features are controversial. The European Organization for Research and Treatment of Cancer (EORTC) 22922 and National Cancer Institute of Canada Clinical Trials Group MA20 trials reporting improved 10-year disease-free survival with lymph node irradiation included patients with high-risk N0 disease, but, to the authors' knowledge, benefits in patients receiving modern systemic therapy are uncertain...
March 23, 2017: Cancer
https://www.readbyqxmd.com/read/28332033/surgeon-attitudes-and-use-of-mri-in-patients-newly-diagnosed-with-breast-cancer
#12
Monica Morrow, Sarah T Hawley, M Chandler McLeod, Ann S Hamilton, Kevin C Ward, Steven J Katz, Reshma Jagsi
BACKGROUND: Usage of magnetic resonance imaging (MRI) in newly diagnosed breast cancer patients is increasing, despite scant evidence that it improves outcomes. Little is known about the knowledge, perspectives, and clinical characteristics of surgeons associated with MRI use. METHODS: Women with early-stage breast cancer undergoing definitive surgery between July 2013 and August 2015 were identified from the Los Angeles and Georgia Surveillance, Epidemiology and End Results (SEER) registries and were asked to name their attending surgeons...
March 22, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28329092/secretor-and-salivary-abo-blood-group-antigen-status-predict-rotavirus-vaccine-take-in-infants
#13
RANDOMIZED CONTROLLED TRIAL
Abdul Momin Kazi, Margaret M Cortese, Ying Yu, Benjamin Lopman, Ardythe L Morrow, Jessica A Fleming, Monica M McNeal, A Duncan Steele, Umesh D Parashar, Anita K M Zaidi, Asad Ali
Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for rotaviruses and can be measured in saliva. Among 181 Pakistani infants in a G1P[8] rotavirus vaccine trial who were seronegative at baseline, anti-rotavirus immunoglobulin A seroconversion rates after 3 vaccine doses differed significantly by salivary HBGA phenotype, with the lowest rate (19%) among infants who were nonsecretors (ie, who did not express the carbohydrate synthesized by FUT2), an intermediate rate (30%) among secretors with non-blood group O, and the highest rate (51%) among secretors with O blood group...
March 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28327961/evaluation-of-breast-tissue-with-confocal-strip-mosaicking-microscopy-a-test-approach-emulating-pathology-like-examination
#14
Sanjee Abeytunge, Bjorg Larson, Gary Peterson, Monica Morrow, Milind Rajadhyaksha, Melissa P Murray
No abstract text is available yet for this article.
March 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28323914/menopause-is-a-determinant-of-breast-aromatase-expression-and-its-associations-with-bmi-inflammation-and-systemic-markers
#15
Kristy A Brown, Neil M Iyengar, Xi Kathy Zhou, Ayca Gucalp, Kotha Subbaramaiah, Hanhan Wang, Dilip D Giri, Monica Morrow, Domenick J Falcone, Nils K Wendel, Lisle A Winston, Michael Pollak, Anneloor Dierickx, Clifford A Hudis, Andrew J Dannenberg
Context: Most estrogen-dependent breast cancers occur after menopause, despite low levels of circulating estrogens. Breast expression of the estrogen-biosynthetic enzyme, aromatase, is proposed to drive breast cancer development after menopause. However, the effects of menopause on breast aromatase expression are unknown. Objective: To determine the effect of menopause on breast aromatase expression in relation to body mass index (BMI), white adipose tissue inflammation (WATi), and systemic markers of metabolic dysfunction...
May 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28270386/metabolic-obesity-adipose-inflammation-and-elevated-breast-aromatase-in-women-with-normal-body-mass-index
#16
Neil M Iyengar, Kristy A Brown, Xi Kathy Zhou, Ayca Gucalp, Kotha Subbaramaiah, Dilip D Giri, Heba Zahid, Priya Bhardwaj, Nils K Wendel, Domenick J Falcone, Hanhan Wang, Samantha Williams, Michael Pollak, Monica Morrow, Clifford A Hudis, Andrew J Dannenberg
Obesity is associated with breast white adipose tissue (WAT) inflammation, elevated levels of the estrogen biosynthetic enzyme, aromatase, and systemic changes that have been linked to the pathogenesis of breast cancer. Here, we determined whether metabolic obesity, including changes in breast biology and systemic effects, occurs in a subset of women with normal body mass index (BMI). Breast WAT and fasting blood were collected from 72 women with normal BMI (<25 kg/m(2)) undergoing mastectomy for breast cancer risk reduction or treatment...
April 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28170472/genetic-testing-and-counseling-among-patients-with-newly-diagnosed-breast-cancer
#17
LETTER
Allison W Kurian, Kent A Griffith, Ann S Hamilton, Kevin C Ward, Monica Morrow, Steven J Katz, Reshma Jagsi
No abstract text is available yet for this article.
February 7, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28167568/pathologic-complete-response-with-neoadjuvant-doxorubicin-and-cyclophosphamide-followed-by-paclitaxel-with-trastuzumab-and-pertuzumab-in-patients-with-her2-positive-early-stage-breast-cancer-a-single-center-experience
#18
Jasmeet C Singh, Anita Mamtani, Andrea Barrio, Monica Morrow, Steven Sugarman, Lee W Jones, Anthony F Yu, Daniel Argolo, Lilian M Smyth, Shanu Modi, Sarah Schweber, Camilla Boafo, Sujata Patil, Larry Norton, Jose Baselga, Clifford A Hudis, Chau Dang
OBJECTIVES: Trastuzumab (H) and pertuzumab (P) with standard chemotherapy is approved for use in the neoadjuvant setting for human epidermal growth receptor 2 -positive patients. A retrospective analysis was performed of patients treated with dose-dense (dd) doxorubicin and cyclophosphamide (AC) followed by paclitaxel (T), trastuzumab, and pertuzumab (THP) in the neoadjuvant setting. Here, the pathologic complete response (pCR) rates are reported. METHODS: An electronic medical record review was conducted of patients treated with HP-based therapy in the neoadjuvant setting from September 1, 2013, to March 1, 2015...
February 2017: Oncologist
https://www.readbyqxmd.com/read/28160790/trends-and-controversies-in-multidisciplinary-care-of-the-patient-with-breast-cancer
#19
REVIEW
Laura S Dominici, Monica Morrow, Elizabeth Mittendorf, Jennifer Bellon, Tari A King
No abstract text is available yet for this article.
December 2016: Current Problems in Surgery
https://www.readbyqxmd.com/read/28160789/in-brief
#20
Laura S Dominici, Monica Morrow, Elizabeth Mittendorf, Jennifer Bellon, Tari A King
No abstract text is available yet for this article.
December 2016: Current Problems in Surgery
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