keyword
https://read.qxmd.com/read/38281296/omission-of-axillary-lymph-node-dissection-for-breast-cancer-patients-with-three-or-more-positive-sentinel-lymph-nodes
#21
JOURNAL ARTICLE
Saranya Prathibha, McKenzie White, Madison Kolbow, Jane Yuet Ching Hui, David Brauer, Jacob Ankeny, Eric H Jensen, Christopher J LaRocca, Schelomo Marmor, Todd M Tuttle
PURPOSE: The ACOSOG Z0011 (Z11) trial assessed the benefit of axillary dissection (ALND) for breast cancer patients with sentinel lymph node (SLN) metastases; however, Z11 excluded patients with ≥ 3 positive SLNs. We analyzed trends in ALND omission in patients with ≥ 3 positive SLNs. METHODS: Women with ≥ 3 positive SLNs who underwent breast-conserving surgery (BCS) or mastectomy between 2018 and 2020 in the National Cancer Database were included using SLN codes initiated in 2018...
January 28, 2024: Breast Cancer Research and Treatment
https://read.qxmd.com/read/38280968/rethinking-surgical-revisions-impact-of-the-monarche-trial-on-axillary-dissection-in-hormone-positive-her2-negative-early-breast-cancer-patients-potentially-eligible-for-abemaciclib
#22
JOURNAL ARTICLE
Thomas Gaillard, Jeanne Piketty, Jean-Guillaume Feron, Noemie Girard, Lea Pauly, Elodie Gauroy, Lauren Darrigues, Beatriz Grandal, Jean-Yves Pierga, Anne-Sophie Hamy-Petit, Fabien Reyal, Enora Laas
INTRODUCTION: The MonarchE trial explored the use of abemaciclib, a CDK4/6 inhibitor, as an adjuvant treatment in high-risk early-stage luminal-like breast cancer. The study's inclusion criteria, especially the N2 status, may require revisiting surgical interventions, including invasive axillary lymph node dissection (ALND)-a procedure that current guidelines generally do not recommend. METHODS: We conducted a single-centre, retrospective, observational cohort study on non-metastatic breast cancer patients managed from 2002 to 2011, at the Institut Curie...
January 27, 2024: British Journal of Cancer
https://read.qxmd.com/read/38270828/does-neoadjuvant-chemotherapy-in-clinical-t1-t2-n0-triple-negative-breast-cancer-increase-the-extent-of-axillary-surgery
#23
JOURNAL ARTICLE
Chandler S Cortina, Jan Irene Lloren, Christine Rogers, Morgan K Johnson, Adrienne N Cobb, Chiang-Ching Huang, Amanda L Kong, Puneet Singh, Mediget Teshome
BACKGROUND: Current management strategies for early-stage triple-negative breast cancer (TNBC) include upfront surgery to determine pathologic stage to guide chemotherapy recommendations, or neoadjuvant chemotherapy (NAC) to de-escalate surgery, elucidate tumor response, and determine the role of adjuvant chemotherapy. However, patients who receive NAC with residual pathological nodal (pN) involvement require axillary lymph node dissection (ALND) as they are Z11/AMAROS ineligible. We aimed to evaluate the impact of NAC compared with upfront surgery on pN status and ALND rates in cT1-2N0 TNBC...
January 25, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38268018/association-between-postoperative-pathological-results-and-non-sentinel-nodal-metastasis-in-breast-cancer-patients-with-sentinel-lymph-node-positive-breast-cancer
#24
JOURNAL ARTICLE
Lingguang Dong, Suosu Wei, Zhen Huang, Fei Liu, Yujie Xie, Jing Wei, Chongde Mo, Shengpeng Qin, Quanqing Zou, Jianrong Yang
OBJECTIVE: For patients with 1-2 positive sentinel lymph nodes (SLN) identified by biopsy, the necessity of axillary lymph node dissection (ALND) remains a matter of debate. The primary aim of this study was to investigate the association between postoperative pathological factors and non-sentinel lymph node (NSLN) metastases in Chinese patients diagnosed with sentinel node-positive breast cancer. METHODS: This research involved a total of 280 individuals with SLN-positive breast cancer...
January 24, 2024: World Journal of Surgical Oncology
https://read.qxmd.com/read/38229843/axillary-surgery-in-oncologic-breast-surgery-a-narrative-review
#25
REVIEW
Tove Filtenborg Tvedskov
BACKGROUND AND OBJECTIVE: With the improved survival for breast cancer there is now an increased focus on quality of life after treatment. Axillary surgery is known to be associated with significant risk of arm morbidity feared by the patients, and several studies have shown de-escalation is possible in different settings. In this review, an overview will be given on new techniques and procedures for de-escalation of axillary surgery in breast cancer patients and the subsequent implications for adjuvant systemic treatment...
December 26, 2023: Gland Surgery
https://read.qxmd.com/read/38217946/is-routine-axillary-lymph-node-dissection-needed-to-tailor-systemic-treatments-for-breast-cancer-patients-in-the-era-of-molecular-oncology-a-position-paper-of-the-italian-national-association-of-breast-surgeons-anisc
#26
REVIEW
Nicola Rocco, Matteo Ghilli, Annalisa Curcio, Marina Bortul, Stefano Burlizzi, Carlo Cabula, Roberta Cabula, Alberta Ferrari, Secondo Folli, Lucio Fortunato, Patrizia Frittelli, Oreste Gentilini, Sara Grendele, Massimo Maria Grassi, Simona Grossi, Francesca Magnoni, Roberto Murgo, Dante Palli, Francesca Rovera, Alessandro Sanguinetti, Mario Taffurelli, Giovanni Tazzioli, Daniela Andreina Terribile, Francesco Caruso, Viviana Galimberti
BACKGROUND: De-escalation of axillary surgery in breast cancer (BC) management began when sentinel lymph node biopsy (SLNB) replaced axillary lymph node dissection (ALND) as standard of care in patients with node-negative BC. The second step consolidated ALND omission in selected subgroups of BC patients with up to two macrometastases and recognized BC molecular and genomic implication in predicting prognosis and planning adjuvant treatment. Outcomes from the recent RxPONDER and monarchE trials have come to challenge the previous cut-off of two SLN in order to inform decisions on systemic therapies for hormone receptor-positive (HR+), human epidermal growth factor receptor type-2 (HER2) negative BC, as the criteria included a cut-off of respectively three and four SLNs...
January 6, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38193547/adherence-rate-to-alliance-for-clinical-trials-in-oncology-z0011-trial-based-on-breast-cancer-subtype
#27
JOURNAL ARTICLE
Taylor Maramara, Mei-Chin Hsieh, Mahin Janjua, Tingting Li, Xiao-Cheng Wu, Mallory Williams, Margo Shoup, Quyen D Chu
INTRODUCTION: ACOSOG Z0011 trial (Z11) demonstrated no survival advantage with completion axillary node dissection (ALND) for patients with T1-2 breast cancer, 1-2 positive sentinel lymph nodes (SLN) who received adjuvant chemoradiation therapy. Over 70% of the cohort had ER+ tumors. There is paucity of data on the adherence rate to Z11, as well as a dearth of data on the applicability of Z11 for the different subtypes. We conducted a large hospital-based study to evaluate the adherence rate to Z0011 based on subtypes...
January 9, 2024: Journal of the American College of Surgeons
https://read.qxmd.com/read/38153534/omission-of-axillary-lymph-node-dissection-in-breast-cancer-patients-with-micrometastasis-or-isolated-tumor-cells-in-sentinel-lymph-nodes-a-12-year-experience-in-a-tertiary-breast-unit
#28
JOURNAL ARTICLE
Nuno Sousa, Bárbara Peleteiro, José Luis Fougo
INTRODUCTION: After the IBCSG 23-01 trial, our breast center no longer performed axillary lymph node dissection (ALND) after detection of isolated tumor cells (ITC) or micrometastasis in the sentinel lymph nodes (SLN). A recent study suggested that up to half of the patients with micrometastasis in the SLN could benefit from ALND in terms of disease-free survival (DFS) and overall survival (OS). METHODS: This retrospective, unicentric, study analyzed 261 consecutive cT1-3 cN0 breast cancer patients with ITC or micrometastasis in their SLN...
December 27, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38133150/performance-and-oncologic-safety-of-sentinel-lymph-node-biopsy-after-neoadjuvant-chemotherapy-results-from-a-tertiary-care-center-in-lebanon
#29
JOURNAL ARTICLE
Mariam Zahwe, Aya El Sammak, Karim Ataya, Christelle Jabbour, Ayman Bsat, Bassel Hafez, Christine Atallah, Mira Kheil, Mohamad Ali Maktabi, Bashar Hassan, Vahe Panossian, Hazem Assi, Jaber Abbas, Eman Sbaity
BACKGROUND: The feasibility of sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy (NACT) in initially node-positive patients is still controversial. We aim to evaluate the oncologic outcomes of SLNB after NACT and further compare the results between those who were initially node-negative and node-positive. METHODS: This is a retrospective cohort that included patients diagnosed with invasive breast cancer and had surgical management between January 2010 and December 2016...
December 22, 2023: Cancer Medicine
https://read.qxmd.com/read/38114365/the-impact-of-sentinel-lymph-node-biopsy-on-female-patients-with-t3-4c-breast-cancer-and-1-2-positive-lymph-nodes-a-population-based-cohort-study
#30
JOURNAL ARTICLE
Hanzhao Yang, Yadong Sun, Peili Wang, Jianghua Qiao, Chengzheng Wang, Zhenzhen Liu
PURPOSE: This study aimed to evaluate the efficacy of sentinel lymph node biopsy (SLNB) in patients diagnosed with cT3-4c breast cancer with no more than 2 positive sentinel lymph nodes. METHODS: Using data from the Surveillance, Epidemiology, and End Results (SEER) database, this retrospective study identified patients diagnosed with T3-4c breast cancer between 2010 and 2015. These patients were then categorized into 2 groups: the SLNB group, which underwent examination of 1-5 regional lymph nodes and the axillary lymph node dissection (ALND) group, which underwent examination of ≥10 regional lymph nodes...
November 17, 2023: Clinical Breast Cancer
https://read.qxmd.com/read/38097994/lymphovascular-invasion-is-a-significant-risk-factor-for-non-sentinel-nodal-metastasis-in-breast-cancer-patients-with-sentinel-lymph-node-sln-positive-breast-cancer-a-cross-sectional-study
#31
REVIEW
Chunyu Wei, Yongqing Deng, Suosu Wei, Zhen Huang, Yujie Xie, Jinan Xu, Lingguang Dong, Quanqing Zou, Jianrong Yang
BACKGROUND: A connection between lymphovascular invasion and axillary lymph node metastases in breast cancer has been observed, but the findings are inconsistent and primarily based on research in Western populations. We investigated the association between lymphovascular invasion and non-sentinel lymph node (non-SLN) metastasis in breast cancer patients with sentinel lymph node (SLN) metastasis in western China. METHODS: This study comprised 280 breast cancer patients who tested positive for SLN through biopsy and subsequently underwent axillary lymph node dissection (ALND) at The People's Hospital of Guangxi Zhuang Autonomous Region between March 2013 and July 2022...
December 14, 2023: World Journal of Surgical Oncology
https://read.qxmd.com/read/38097882/impact-of-neoadjuvant-chemotherapy-on-breast-cancer-related-lymphedema-after-axillary-lymph-node-dissection-a-retrospective-cohort-study
#32
JOURNAL ARTICLE
Miaomiao Jia, Lihui Pan, Haibo Yang, Jinnan Gao, Fan Guo
PURPOSE: We aimed to evaluate whether neoadjuvant chemotherapy (NAC) could be a risk factor for breast cancer-related lymphedema (BCRL) associated with axillary lymph node dissection (ALND). PATIENTS AND METHODS: A total of 596 patients with cT0-4N0-3M0 breast cancer who underwent ALND and chemotherapy were retrospectively analyzed between March 2012 and March 2022. NAC was administered in 188 patients (31.5%), while up-front surgery in 408 (68.5%). Univariate and multivariable Cox regression analyses were performed to determine whether NAC was an independent risk factor for BCRL...
April 2024: Breast Cancer Research and Treatment
https://read.qxmd.com/read/38071708/long-term-patient-reported-arm-symptoms-in-breast-cancer-survivors
#33
JOURNAL ARTICLE
Alison Laws, Mirelle Lagendijk, Samantha Grossmith, Melissa Hughes, Nancy U Lin, Elizabeth A Mittendorf, A Heather Eliassen, Tari A King, Laura S Dominici
BACKGROUND: Understanding long-term arm symptoms in breast cancer survivors is critical given excellent survival in the modern era. METHODS: This cross-sectional study included patients treated for stage 0-III breast cancer at our institution from 2002 to 2012. Patient-reported arm symptoms were collected from the EORTC QLQ-BR23 questionnaire. We used linear regression to evaluate adjusted associations between locoregional treatments and the continuous Arm Symptom (AS) score (0-100; higher score reflects more symptoms)...
March 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38046972/detection-of-axillary-lymph-node-involvement-in-early-stage-breast-cancer-comparison-between-staging-18-f-2-fluoro-2-deoxy-d-glucose-positron-emission-tomography-computed-tomography-scans-mammography-and-sentinel-lymph-node-biopsy
#34
JOURNAL ARTICLE
Raju Gupta, Jayanta Das, Sayantani Sinha, Sanjit Agarwal, Abhisekh Sharma, Rosina Ahmed, Aditi Chanda, Indu Arun, Soumendranath Ray
AIMS: The aim of this study was to evaluate the role of 18 F-2-fluoro-2-deoxy-D-glucose (18 F-FDG) positron emission tomography-computed tomography (PET-CT) scan in the detection of axillary lymph node (ALN) involvement and comparison with sentinel lymph node biopsy (SLNB) in operable early-stage breast cancer (EBC). SETTINGS AND DESIGN: It is a retrospective analysis of staging PET-CT scan of EBC. METHODS: A total of 128 patients with histopathologically proven breast cancer (BC) were included in the study...
2023: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://read.qxmd.com/read/38038792/prevention-of-seroma-formation-and-its-sequelae-after-axillary-lymph-node-dissection-an-up-to-date-systematic-review-and-guideline-for-surgeons
#35
REVIEW
Merel A Spiekerman van Weezelenburg, Maikel J A M Bakens, Jean H T Daemen, Loeki Aldenhoven, Elisabeth R M van Haaren, Alfred Janssen, Yvonne L J Vissers, Geerard L Beets, James van Bastelaar
INTRODUCTION: Seroma formation after axillary lymph node dissection (ALND) remains a troublesome complication with significant morbidity. Numerous studies have tried to identify techniques to prevent seroma formation. The aim of this systematic review and network meta-analysis is to use available literature to identify the best intervention for prevention of seroma after standalone ALND. METHODS: A literature search was performed for all comparative articles regarding seroma formation in patients undergoing a standalone ALND or ALND with breast-conserving surgery in the last 25 years...
December 1, 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/38018862/should-patients-with-hormone-receptor-positive-her2-negative-breast-cancer-and-one-or-two-positive-sentinel-nodes-undergo-axillary-dissection-to-determine-candidacy-for%C3%A2-adjuvant-abemaciclib
#36
JOURNAL ARTICLE
Austin D Williams, Karen Ruth, Saba S Shaikh, Mahtab Vasigh, Mary T Pronovost, Allison A Aggon, Andrea S Porpiglia, Richard J Bleicher
BACKGROUND: The monarchE trial demonstrated improved outcomes with the use of adjuvant abemaciclib in patients with high-risk hormone receptor-positive, HER2-negative (HR+/HER2-) breast cancer defined as ≥4 positive lymph nodes (+LNs) or one to three +LNs with one or more additional high-risk features (HRFs). The proportion of patients with one or two positive sentinel lymph nodes (+SLNs) without HRFs who had ≥4 +LNs at the time of completion axillary lymph node dissection (cALND), and who therefore qualified for receipt of abemaciclib, was investigated...
November 29, 2023: Cancer
https://read.qxmd.com/read/38018520/occult-breast-cancer-patients-with-mastectomy-have-better-prognosis-than-those-with-breast-conserving-therapy
#37
JOURNAL ARTICLE
Jiayi Li, Gang Liu, Ziqi Jia, Fei Ren, Dawei Dong, Menglu Zhang, Xiang Wang, Yipeng Wang
Background: This single-center retrospective study compared the efficacy of breast-conserving therapy along with axillary lymph node dissection (ALND) with mastectomy and ALND with regard to survival of Chinese patients with occult breast cancer. Materials & methods: Univariate Kaplan-Meier analysis and multivariate Cox proportional hazards model were used to compare treatments and prognosis. Results: A total of 111 patients with a median follow-up of 72.9 months were included. 39 patients with mastectomy + ALND had better disease-free survival than 72 patients with breast-conserving therapy + ALND (HR = 0...
November 2023: Future Oncology
https://read.qxmd.com/read/38001613/conservative-axillary-surgery-may-prevent-arm-lymphedema-without-increasing-axillary-recurrence-in-the-surgical-management-of-breast-cancer
#38
REVIEW
Masakuni Noguchi, Masafumi Inokuchi, Miki Yokoi-Noguchi, Emi Morioka, Yusuke Haba
Axillary lymph node dissection (ALND) has been associated with postoperative morbidities, including arm lymphedema, shoulder dysfunction, and paresthesia. Sentinel lymph node (SLN) biopsy emerged as a method to assess axillary nodal status and possibly obviate the need for ALND in patients with clinically node-negative (cN0) breast cancer. The majority of breast cancer patients are eligible for SLN biopsy only, so ALND can be avoided. However, there are subsets of patients in whom ALND cannot be eliminated...
November 9, 2023: Cancers
https://read.qxmd.com/read/37964832/non-sentinel-lymph-node-metastases-risk-factors-in-patients-with-breast-cancer-with-one-or-two-sentinel-lymph-node-macro-metastases
#39
JOURNAL ARTICLE
Liu-Yan Xu, Jing Zhao, Xuan Wang, Xin-Yan Jin, Bei-Bei Wang, Ying-Yi Fan, Xiao-Hua Pei
Approximately 59 % of patients with breast cancer with one or two sentinel lymph nodes (1-2 SLN) macrometastases do not benefit from axillary lymph node dissection (ALND), which may also incur morbidities. It is necessary to evaluate the association between various clinicopathological characteristics and non-sentinel lymph node metastases (non-SLNM) in patients with breast cancer with 1-2 SLN macrometastases, and determine whether they 1-2 should avoid ALND. Eight electronic literature databases (PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Chinese Scientific Journal, Wanfang, and Chinese Biomedical Literature) were searched from their inception to June 30, 2023, and two reviewers independently extracted the data and assessed the risk of bias...
November 2023: Heliyon
https://read.qxmd.com/read/37961801/advantages-of-contrast-enhanced-ultrasound-in-the-localization-and-diagnostics-of-sentinel-lymph-nodes-in-breast-cancer
#40
JOURNAL ARTICLE
Qiuhui Yang, Yeqin Fu, Jiaxuan Wang, Hongjian Yang, Xiping Zhang
Sentinel lymph nodes (SLNs) are the first station of lymph nodes that extend from the breast tumor to the axillary lymphatic drainage. The pathological status of these LNs can predict that of the entire axillary lymph node. Therefore, the accurate identification of SLNs is necessary for sentinel lymph node biopsy (SLNB) to replace axillary lymph node dissection (ALND). The quality of life and prognosis of breast cancer patients are related to proper surgical treatment after the precise identification of SLNs...
November 15, 2023: Journal of Zhejiang University. Science. B
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