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https://www.readbyqxmd.com/read/27900818/healthcare-costs-reduced-after-incorporating-the-results-of-the-american-college-of-surgeons-oncology-group-z0011-trial-into-clinical-practice
#1
Michelle M Fillion, Katherine E Glass, Joe Hayek, Allison Wehr, Gary Phillips, Alicia Terando, Doreen M Agnese
The purpose of our study was to quantitate the changes in axillary lymph node dissection (ALND), frozen section (FS), and the impact on costs after the publication of the American College of Surgeons Oncology Group (ACOSOG) Z0011 trial. We compared axillary nodal management and cost data in breast cancer patients who met Z0011 criteria and were treated with lumpectomy and sentinel lymph nodes (SLN) biopsy from 2007 to July 2013. Of 800 patients, 67 (13.5%) and 34 (12.5%) patients in the pre- and post-Z0011 era had 1-2 positive SLN...
November 30, 2016: Breast Journal
https://www.readbyqxmd.com/read/27878556/venous-anomalies-of-the-axilla-a-single-institution-experience
#2
Viviana Sollazzo, Gaetano Luglio, Emanuela Esposito, Rosa Di Micco, Mariano Cesare Giglio, Roberto Peltrini, Pietro Schettino, Bruno Amato, Giovanni Domenico De Palma, Gennaro Limite
AIM: Surgical treatment is still the cornerstone in the treatment of breast cancer, a very common neoplasia, particularly affecting the female elderly population. Axillary dissection is crucial in the treatment of some tumours, but variations in axillary vessels anatomy are poorly described in standard anatomy and surgical textbook. We aimed to describe anatomical variations in axillary vessels found in our institutional experience. PATIENTS AND METHODS: A prospective 3-year study was conducted in our institution from January 2012 to December 2014...
November 22, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27852049/a-nomogram-to-predict-the-probability-of-axillary-lymph-node-metastasis-in-female-patients-with-breast-cancer-in-china-a-nationwide-multicenter-10-year-epidemiological-study
#3
Jian Zhang, Xiao Li, Rong Huang, Wei-Liang Feng, Ya-Nan Kong, Feng Xu, Lin Zhao, Qing-Kun Song, Jing Li, Bao-Ning Zhang, Jin-Hu Fan, You-Lin Qiao, Xiao-Ming Xie, Shan Zheng, Jian-Jun He, Ke Wang
Axillary lymph node dissection (ALND) or sentinel lymph node biopsy (SLNB) alone may lead to postoperative complications. Among patients with positive ALN in the preoperative examination, approximately 40% patients do not have SLN metastasis. Herein, we aimed to develop a model to predict the probability of ALN metastasis as a preoperative tool to support clinical decision-making. We retrospectively analyzed the clinicopathological features of 4211 female patients with breast cancer who were diagnosed in seven breast cancer centers representing entire China, over 10 years (1999-2008)...
November 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27829404/investigation-of-optical-coherence-micro-elastography-as-a-method-to-visualize-micro-architecture-in-human-axillary-lymph-nodes
#4
Kelsey M Kennedy, Lixin Chin, Philip Wijesinghe, Robert A McLaughlin, Bruce Latham, David D Sampson, Christobel M Saunders, Brendan F Kennedy
BACKGROUND: Evaluation of lymph node involvement is an important factor in detecting metastasis and deciding whether to perform axillary lymph node dissection (ALND) in breast cancer surgery. As ALND is associated with potentially severe long term morbidity, the accuracy of lymph node assessment is imperative in avoiding unnecessary ALND. The mechanical properties of malignant lymph nodes are often distinct from those of normal nodes. A method to image the micro-scale mechanical properties of lymph nodes could, thus, provide diagnostic information to aid in the assessment of lymph node involvement in metastatic cancer...
November 9, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27810698/intraoperative-assessment-of-sentinel-lymph-node-by-one-step-nucleic-acid-amplification-in-breast-cancer-patients-after-neoadjuvant-treatment-reduces-the-need-for-a-second-surgery-for-axillary-lymph-node-dissection
#5
Martin Espinosa-Bravo, Joaquin Navarro-Cecilia, Manuel Ramos Boyero, Sebastian Diaz-Botero, Basilio Dueñas Rodríguez, Carolina Luque López, Teresa Ramos Grande, Ricardo Ruano Perez, Vicente Peg, Isabel T Rubio
PURPOSE: Sentinel lymph node (SLN) biopsy has been shown to be both accurate and feasible for women who receive neoadjuvant chemotherapy (NAC). Intraoperative assessment of SLN by frozen sections can produce false negative results. The aim of this study was to compare two different techniques of intraoperative assessment of SLN in breast cancer patients treated with NAC: frozen section (FS) and molecular assay (OSNA). METHODS: A multicenter cohort of 320 consecutive breast cancer patients treated with NAC between 2010 and 2014 was analyzed...
October 28, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27787592/contribution-of-spect-ct-for-sentinel-node-localization-in-patients-with-ipsilateral-breast-cancer-relapse
#6
Pablo Borrelli, Maarten L Donswijk, Marcel P Stokkel, Suzana C Teixeira, Harm van Tinteren, Emiel J Th Rutgers, Renato A Valdés Olmos
BACKGROUND: In recent years repeat sentinel node (SN) biopsy has been proven to be feasible in local breast cancer recurrence (LBCR). However, in these patients SNs outside the ipsilateral axilla are frequently observed. This study evaluates the contribution of SPECT/CT for SN localization and surgical adjustment in LBCR patients. METHODS: SN biopsy was performed in 122 LBCR patients (median age 60.5 years, range 24-87), enrolled from August 2006 to July 2015. Median disease-free time lapse was 109...
October 27, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27778360/sentinel-lymph-node-biopsy-and-aberrant-lymphatic-drainage-in-recurrent-breast-cancer-findings-likely-to-change-treatment-decisions
#7
Hasan Karanlik, Ilker Ozgur, Berkay Kilic, Alisan Fathalizadeh, Yasemin Sanli, Semen Onder, Pinar Saip, Fatma Sen, Bahadir M Gulluoglu
BACKGROUND AND OBJECTIVES: It is not clear whether sentinel lymph node biopsy (SLNB) can be applied to patients with a second breast cancer or recurrence occurring at previously treated breast. The purpose of this study was to assess the feasibility of SLNB procedure in patients with recurrent breast cancer. METHODS: Patients with non-metastatic recurrent N0 breast cancer at ipsilateral breast were included. Patients were grouped according to their initial breast, axilla, and overall surgery...
October 25, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27769634/upper-outer-boundaries-of-the-axillary-dissection-result-of-the-sentibras-protocol-multicentric-protocol-using-axillary-reverse-mapping-in-breast-cancer-patients-requiring-axillary-dissection
#8
C Nos, K B Clough, P Bonnier, S Lasry, G Le Bouedec, B Flipo, J-M Classe, M-C Missana, V Doridot, S Giard, H Charitansky, A Charles-Nelson, A-S Bats, C Ngo
BACKGROUND: Two thirds of node-positive breast cancer patients have limited pN1 disease and could benefit from a less extensive axillary lymph node dissection (ALND). METHODS: 172 breast cancers patients requiring an ALND were prospectively enrolled in the Sentibras Protocol of Axillary Reverse Mapping (ARM). Radioisotope was injected in the ipsilateral hand the day before surgery. ALND was standard. Removed lymph nodes were classified into non radioactive nodes and radioactive nodes (ARM nodes)...
August 26, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27738336/axillary-and-internal-mammary-sentinel-lymph-node-biopsy-in-breast-cancer-after-neoadjuvant-chemotherapy
#9
Xiao-Shan Cao, Hui-Juan Li, Bin-Bin Cong, Xiao Sun, Peng-Fei Qiu, Yan-Bing Liu, Chun-Jian Wang, Yong-Sheng Wang
With the improvement of neoadjuvant chemotherapy (NAC), the proportion of pathological complete response (pCR) in the breast and axillary lymph node (ALN) is increasing. The evaluation of pCR does not include the status of internal mammary lymph node (IMLN). This study is to evaluate the roles of both axillary sentinel lymph node biopsy (ASLNB) and internal mammary sentinel lymph node biopsy (IM-SLNB) in breast cancer patients after NAC. There were 74 patients enrolled into this study. IM-SLNB was performed on patients with radioactive internal mammary sentinel lymph node (IM-SLN)...
October 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27721717/lymph-node-surgery-stepwise-retirement-for-the-breast-surgeon
#10
Julia Landin, Walter P Weber
Axillary lymph node dissection (ALND) has been standard of care for all patients with breast cancer until the 1990s. The stepwise retreat of breast surgeons from the axilla began after the introduction of the sentinel lymph node procedure. The evidence based clinical trend toward the omission of ALND has advanced to include patients with affected nodes, and several ongoing randomized controlled trials are evaluating the remaining indications for ALND. Conflicting with this trend toward less axillary surgery, indication and extent of regional nodal irradiation are currently broadened, equally supported by evidence from randomized trials...
August 2016: Breast Care
https://www.readbyqxmd.com/read/27681760/outcomes-of-post-mastectomy-radiation-therapy-in-patients-receiving-axillary-lymph-node-dissection-after-positive-sentinel-lymph-node-biopsy
#11
Michael C Stauder, Abigail S Caudle, Pamela K Allen, Simona F Shaitelman, Benjamin D Smith, Karen E Hoffman, Thomas A Buchholz, Mariana Chavez-Macgregor, Kelly K Hunt, Funda Meric-Bernstam, Wendy A Woodward
PURPOSE: We sought to determine the rate of postmastectomy radiation therapy (PMRT) among women treated with axillary lymph node dissection (ALND) after positive sentinel lymph node (SLN) biopsy results and to establish the effect of negative ALND results and PMRT on locoregional recurrence (LRR) and overall survival (OS). METHODS AND MATERIALS: All patients were treated with mastectomy and ALND after positive SLN biopsy results. All patients had clinical N0 or NX disease at the time of mastectomy and received no neoadjuvant therapy...
November 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675634/impact-of-radiation-on-local-regional-control-in-women-with-node-positive-breast-cancer-treated-with-neoadjuvant-chemotherapy-nac-and-axillary-lymph-node-dissection-alnd-results-from-acosog-z1071-alliance
#12
B G Haffty, K V Ballman, K K Hunt, L M McCall, J C Boughey
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27665585/use-of-a-prospective-surveillance-model-to-prevent-breast-cancer-treatment-related-lymphedema-a-single-center-experience
#13
Eun Joo Yang, Soyeon Ahn, Eun-Kyu Kim, Eunyoung Kang, Youngmi Park, Jae-Young Lim, Sung-Won Kim
PURPOSE: Breast cancer patients undergoing axillary lymph node dissection (ALND) are at risk of lymphedema (LE). Successful management of LE relies on early diagnosis using sensitive modalities. In the current study, we explored the effectiveness of a surveillance program for lymphedema management (SLYM) compared to standard care. METHODS: Breast cancer patients who underwent ALND in Seoul National University Bundang Hospital from January 2008 to December 2015 were included in this prospective study...
November 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27640137/impact-of-completion-axillary-lymph-node-dissection-in-patients-with-breast-cancer-and-isolated-tumour-cells-or-micrometastases-in-sentinel-nodes
#14
G Houvenaeghel, J M Boher, F Reyal, M Cohen, J R Garbay, J M Classe, R Rouzier, S Giard, C Faure, H Charitansky, C Tunon de Lara, E Daraï, D Hudry, P Azuar, P Gimbergues, R Villet, P Sfumato, E Lambaudie
BACKGROUND: Omission of completion axillary lymph node dissection (ALND) is a standard practice in patients with breast cancer (BC) and negative sentinel nodes (SNs) but has shown insufficient evidence to be recommended in those with SN invasion. METHODS: A retrospective analysis of a cohort of patients with BC and micrometastases (Mic) or isolated tumour cells (ITCs) in SN. Factors associated with ALND were identified, and patients with ALND were matched to patients without ALND...
November 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27633450/application-of-a-predictive-model-of-axillary-lymph-node-status-in-patients-with-sentinel-node-metastasis-from-breast-cancer-a%C3%A2-retrospective-cohort-study
#15
Salvatore Vieni, Giuseppa Graceffa, Roberta La Mendola, Stefania Latteri, Adriana Cordova, Mario Adelfio Latteri, Calogero Cipolla
BACKGROUND AND OBJECTIVES: The Axillary Lymph Node Dissection (ALND) is the standard treatment in patients with invasive breast cancer and sentinel node metastasis, but in 60% of the cases there is no further axillary neoplastic involvement, so this invasive intervention represents an overtreatment. The purpose of the study is to identify patients with low risk of additional nodal metastases, to omit ALND. METHODS: The MSKCC Additional nodal metastasis nomogram was applied on a sample of 175 patients with invasive breast cancer who underwent ALND after detection of macrometastasis with the extemporaneous examination of the sentinel lymph node...
September 12, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27606623/the-feasibility-and-accuracy-of-sentinel-lymph-node-biopsy-in-initially-clinically-node-negative-breast-cancer-after-neoadjuvant-chemotherapy-a-systematic-review-and-meta-analysis
#16
Chong Geng, Xiao Chen, Xiaohua Pan, Jiyu Li
BACKGROUND: With the increased use of neoadjuvant chemotherapy (NAC) in breast cancer, the timing of sentinel lymph node biopsy (SLNB) has become increasingly important. In this study, we aimed to evaluate the feasibility and accuracy of SLNB for initially clinically node-negative breast cancer after NAC by conducting a systematic review and meta-analysis. METHODS: We searched PubMed, Embase, and the Cochrane Library from January 1, 1993 to November 30, 2015 for studies on initially clinically node-negative breast cancer patients who underwent SLNB after NAC followed by axillary lymph node dissection (ALND)...
2016: PloS One
https://www.readbyqxmd.com/read/27598038/meta-analysis-of-aberrant-lymphatic-drainage-in-recurrent-breast-cancer
#17
REVIEW
M Ahmed, R Baker, I T Rubio
BACKGROUND: Sentinel node biopsy (SNB) in recurrent breast cancer offers targeted axillary staging compared with axillary lymph node dissection (ALND) or no treatment. The evidence for lymphatic mapping in recurrent breast cancer is reviewed, focusing on aberrant drainage and its implications for patient management. METHODS: A meta-analysis of studies evaluating lymphatic mapping in recurrent breast cancer was performed. Outcomes included sentinel node identification, aberrant lymphatic pathways and metastatic node rates in aberrant drainage and ipsilateral axilla...
November 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/27562691/recommendation-for-axillary-lymph-node-dissection-in-women-with-early-breast-cancer-and-sentinel-node-metastasis-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-using-the-grade-system
#18
Tsai-Wei Huang, Ken N Kuo, Kee-Hsin Chen, Chiehfeng Chen, Wen-Hsuan Hou, Wei-Hwa Lee, Tsu-Yi Chao, Jo-Ting Tsai, Chih-Ming Su, Ming-Te Huang, Ka-Wai Tam
BACKGROUND: In 2014, the American Society of Clinical Oncology published an updated clinical practice guideline on axillary lymph node dissection (ALND) for early-stage breast cancer patients. However, these recommendations have been challenged because they were based on data from only one randomized controlled trial (RCT). We evaluated the rationale of these recommendations by systematically reviewing RCTs using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) system...
August 22, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27553957/trends-in-axillary-treatment-for-breast-cancer-patients-undergoing-sentinel-lymph-node-biopsy-as-determined-by-a-questionnaire-from-the-japanese-breast-cancer-society
#19
Shigeru Imoto, Chikako Yamauchi, Yoshifumi Komoike, Koichiro Tsugawa, Daisuke Yotsumoto, Noriaki Wada, Takayuki Ueno, Mari S Oba, Tadahiko Shien, Sadatoshi Sugae, Hitoshi Tsuda, Kimiyasu Yoneyama
BACKGROUND: Sentinel lymph node biopsy (SLNB) alone has been compared with SLNB followed by axillary lymph node dissection (ALND) in sentinel lymph node (SLN)-positive breast cancer patients in randomized phase III trials: the addition of ALND did not further improve the patient's outcome. However, there is still some controversy, regarding the clinical application of SLNB alone. To identify the optimal axillary treatment in the era of SLNB, the Japanese Breast Cancer Society conducted a group study of SLNB in 2014...
August 23, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27531271/-feasibility-analysis-of-sentinel-lymph-node-biopsy-in-patients-with-breast-cancer-after-local-lumpectomy
#20
J Wang, X Wang, W Y Wang, J Q Liu, Z Y Xing, X Wang
OBJECTIVE: To explore the feasibility, safety and clinical application value of sentinel lymph node biopsy(SLNB)in patients with breast cancer after local lumpectomy. METHODS: Clinical data of 195 patients who previously received local lumpectomy from January 2005 to April 2015 were retrospectively analyzed. All the patients with pathologic stage T1-2N0M0 (T1-2N0M0) breast cancer underwent SLNB. Methylene blue, carbon nanoparticles suspension, technetium-99m-labeled dextran, or in combination were used in the SLNB...
July 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
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