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https://www.readbyqxmd.com/read/29721480/practical-consensus-recommendations-regarding-the-management-of-sentinel-lymph-node-issues-in-early-breast-cancer
#1
Vedant Kabra, R Aggarwal, S Vardhan, M Singh, R Khandelwal, S Jain, S Sahani, S Saini, N Deo, R Kaul, P M Parikh, S Aggarwal
Axillary lymph node involvement is a very important poor prognostic factor in the clinical staging and management of breast cancer patients. Traditionally, axillary lymph node dissection (ALND) has been used for determining the status of the axillary lymph nodes. More recently the sentinel lymph node biopsy (SLNB) procedure has gained wider acceptance as the standard of care, having the advantage of being less invasivewhile providing good accuracy. This expert group used data from published literature, practical experience and opinion of a large group of academic oncologists to arrive at these practical consensus recommendations in regards with the use of the two different procedures and other issues in patients with early breast cancer for the benefit of community oncologists...
April 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29705286/preoperative-predictors-of-high-and-low-axillary-nodal-burden-in-z0011-eligible-breast-cancer-patients-with-a-positive-lymph-node-needle-biopsy-result
#2
Geok Hoon Lim, Vidya S Upadhyaya, Hannah Angela Acosta, Jayne Michelley Adolfo Lim, John C Allen, Lester Chee Hao Leong
BACKGROUND: Z0011 trial showed that early breast cancer patients with low axillary nodal burden, may be spared an axillary lymph node dissection with no survival compromise. Axillary lymph node dissection can be reserved for patients with a high axillary nodal burden. We aim to determine the preoperative factors that could distinguish between low and high axillary nodal burden in Z0011 eligible patients with a needle biopsy proven metastatic node. METHOD: Patients who fulfilled Z0011 trial criteria with a positive lymph node needle biopsy and had axillary lymph node dissection (ALND) were recruited...
April 12, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29673015/analysis-of-246-sentinel-lymph-node-biopsies-of-patients-with-clinical-primary-breast-cancer-by-application-of-carbon-nanoparticle-suspension
#3
Shi-Xin Yang, Wen-Song Wei, Qi-Hua Jiang, Yu-Feng Zhou, Wei Qu, Jian-Hong Tu, Qian-Wen Ou-Yang, Zhi-Bing Zhou, Hao-Long Ding, Chun-Wei Xie
AIM: This study aims to explore the accuracy, specificity and laws of axillary lymph node metastasis predicted by sentinel lymph node biopsy (SLNB) by comparing axillary lymph node status via SLNB and axillary lymph node dissection (ALND) with nanocarbon as the tracer. METHODS: Forty six patients were retrospectively analyzed. These patients underwent SLNB with nanocarbon as the tracer from March 2013 to April 2014. RESULTS: Two hundred and forty six patients of sentinel lymph node (SLN) were successfully detected...
April 19, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29652212/development-of-a-normal-tissue-complication-probability-model-for-late-unfavourable-aesthetic-outcome-after-breast-conserving-therapy
#4
Isabelle Kindts, Gilles Defraene, Annouschka Laenen, Saskia Petillion, Erik Van Limbergen, Tom Depuydt, Caroline Weltens
PURPOSE/OBJECTIVES: To develop a normal tissue complication probability (NTCP) model for late unfavourable aesthetic outcome (AO) after breast-conserving therapy. MATERIAL AND METHODS: The BCCT.core software evaluated the AO using standardized photographs of patients treated between 2009 and 2014. Dose maps in 2 Gy equivalents were calculated assuming α/β = 3.6 Gy. Uni- and multivariable logistic regression analysis was performed to study the predictive value of clinicopathological and dosimetric variables for unfavourable AO...
April 13, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29651594/prospective-study-of-shoulder-strength-shoulder-range-of-motion-and-lymphedema-in-breast-cancer-patients-from-pre-surgery-to-5-years-after-alnd-or-slnb
#5
Roser Belmonte, Monique Messaggi-Sartor, Montse Ferrer, Angels Pont, Ferran Escalada
OBJECTIVE: Determine the changes in shoulder strength, shoulder range of motion, and arm volume in breast cancer patients treated with sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND) METHOD: Sixty-eight SLNB and 44 ALND patients were followed up from pre-surgery to 5 years after surgery. Primary outcomes were the differences between affected and non-affected sides for the following: shoulder strength measured by dynamometry, shoulder range of motion measured by goniometry, and lymphedema measured by volume...
April 12, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29626303/axillary-surgery-for-early-stage-node-positive-mastectomy-patients-and-the-use-of-postmastectomy-chest-wall-radiation-therapy
#6
Sara Gaines, Nicholas Suss, Ermilo Barrera, Catherine Pesce, Kristine Kuchta, D J Winchester, Katharine Yao
BACKGROUND: We examined axillary surgery in mastectomy patients with tumor-positive nodes and how the type of axillary surgery impacted use of postmastectomy chest wall radiation therapy (PMRT). METHODS: Using the National Cancer Data Base, we selected patients with AJCC cT1/T2c N0 breast cancer with one to three tumor-positive lymph nodes treated between 2013 and 2014. Type of axillary surgery was analyzed using the FORDS scope of regional lymph node surgery variable...
April 6, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29605705/nsqip-analysis-of-axillary-lymph-node-dissection-rates-for-breast-cancer-implications-for-resident-and-fellow-participation
#7
Nadia F Nocera, Bryan J Pyfer, Lucy M De La Cruz, Abhishek Chatterjee, Paul T Thiruchelvam, Carla S Fisher
INTRODUCTION: Management of the axilla in invasive breast cancer (IBC) has shifted away from more radical surgery such as axillary lymph node dissection (ALND), towards less invasive procedures, such as sentinel lymph node biopsy. Because of this shift, we hypothesize that there has been a national downward trend in ALND procedures, subsequently impacting surgical trainee exposure to this procedure using the ACS-NSQIP database to evaluate this. METHODS: Women with IBC were identified in the ACS-NSQIP database from 2007 to 2014...
March 28, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29599361/the-clinical-usefulness-of-the-ligasure%C3%A2-small-jaw-in-axillary-lymph-node-dissection-in-patients-with-breast-cancer
#8
Yuka Inoue, Nami Yamashita, Hiroki Ueo, Kimihiro Tanaka, Hiroshi Saeki, Eiji Oki, Eriko Tokunaga, Yoshihiko Maehara
BACKGROUND: The LigaSure™ small jaw (LS-SJ) multifunctional tissue sealing system is mainly used in cervical operations. We aimed to evaluate the clinical efficacy of the LS-SJ in axillary lymph node dissection (ALND) in comparison to the conventional method. PATIENTS AND METHODS: Ninety-two patients with breast cancer who underwent total mastectomy and ALND were included in this study. The patients were divided into the LS-SJ group (n=43) and the conventional-ALND (c-ALND) group (n=49)...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29599329/additional-nodal-disease-prediction-in-breast-cancer-with-sentinel-lymph-node-metastasis-based-on-clinicopathological-features
#9
Paolo Orsaria, Emanuele Caredda, Federica Genova, Marco Materazzo, Ilaria Capuano, Gianluca Vanni, Alessandra Vittoria Granai, Adriano DE Majo, Ilaria Portarena, Pierpaolo Sileri, Giuseppe Petrella, Leonardo Palombi, Oreste Claudio Buonomo
AIM: The standard-of-care in breast cancer (BC) with positive sentinel lymph node (SLN) metastasis includes complete axillary lymph node dissection (ALND); however, almost half of such cases have no further tumor burden. This study aimed to assess the clinicopathological factors that predict non-SLN metastasis to define subgroups of SLN-positive patients in whom the axilla may be staged by SLN biopsy alone, while avoiding unnecessary overtreatment. PATIENTS AND METHODS: The records of 191 patients with histologically-proven primary BC who underwent a positive (SLN) biopsy between 2005 and 2017 were reviewed...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29572705/is-low-volume-disease-in-the-sentinel-node-after-neoadjuvant-chemotherapy-an-indication-for-axillary-dissection
#10
Tracy-Ann Moo, Marcia Edelweiss, Sabina Hajiyeva, Michelle Stempel, Monica Raiss, Emily C Zabor, Andrea Barrio, Monica Morrow
BACKGROUND/OBJECTIVE: Intraoperative evaluation of sentinel lymph nodes (SLNs) after neoadjuvant chemotherapy (NAC) has a higher false-negative rate than in the primary surgical setting, particularly for small tumor deposits. Additional tumor burden seen with isolated tumor cells (ITCs) and micrometastases following primary surgery is low; however, it is unknown whether the same is true after NAC. We examined the false-negative rate of intraoperative frozen section (FS) after NAC, and the association between SLN metastasis size and residual disease at axillary lymph node dissection (ALND)...
March 23, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29536376/comparison-of-sentinel-lymph-node-biopsy-between-invasive-lobular-carcinoma-and-invasive-ductal-carcinoma
#11
Yayoi Adachi, Masataka Sawaki, Masaya Hattori, Akiyo Yoshimura, Noami Gondo, Haruru Kotani, Madoka Iwase, Ayumi Kataoka, Sakura Onishi, Kayoko Sugino, Mitsuo Terada, Nanae Horisawa, Makiko Mori, Isao Oze, Hiroji Iwata
BACKGROUND: Recent studies suggested that ALND (axillary lymph node dissection) can be avoided in breast cancer patients with limited SLN (sentinel lymph node) metastasis. However, these trials included only several invasive lobular carcinoma (ILC) cases, and the validity of omitting ALND for ILC remains controversial. Here, we examined whether omitting ALND is feasible in ILC treatment. METHODS: A total of 3771 breast cancer patients underwent surgery for breast cancer at the Aichi Cancer Center Hospital between January 2006 and December 2015...
March 13, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29526557/intracystic-papillary-carcinoma-of-the-breast-experience-of-a-major-chinese-cancer-center
#12
Jun Zhang, Tiemei Zhang, Nan Wu, Xinhua Zhao, Qingsong Wang, Yanyang Jiang, Ming Gao, Lin Gu
BACKGROUND: Intracystic papillary carcinoma (IPC) is a rare breast neoplasm. There are few studies focusing on its clinical features and limited data about its preoperative diagnosis,treatment and outcomes. The purpose of this study is to explore specific characteristics of patients with IPC, investigate its clinicopathological features, prognosis in China and confirm its surgery management. METHODS: We identified 111 patients with IPC from the registry of Tianjin Medical University Cancer Institute and Hospital between 2004 and 2017...
April 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29526019/systematic-versus-sentinel-lymph-node-driven-axillary-lymph-node-dissection-in-clinically-node-negative-patients-with-operable-breast-cancer-results-of-the-gf-gs01-randomized-trial
#13
P Roy, A Leizorovicz, R Villet, C Mercier, J Y Bobin
PURPOSE: Sentinel-lymph-node (SLN) resection seems to minimize systematic axillary-lymph-node dissection (sALND) side effects in operated breast cancer patients. We explored whether SLN resection achieves similar therapeutic outcomes as sALND but with fewer side effects. METHODS: A randomized, controlled, open-label trial with parallel-group design compared sALND restricted to cases with positive SLN biopsy (test arm, n = 774) versus SLN biopsy followed by sALND (control arm, n = 770)...
March 10, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29511992/major-reduction-in-axillary-lymph-node-dissections-after-neoadjuvant-systemic-therapy-for-node-positive-breast-cancer-by-combining-pet-ct-and-the-mari-procedure
#14
M E M van der Noordaa, F H van Duijnhoven, M E Straver, E J Groen, M Stokkel, C E Loo, P H M Elkhuizen, N S Russell, M T F D Vrancken Peeters
BACKGROUND: Axillary lymph node dissection (ALND) is frequently performed for node-positive (cN+) breast cancer patients. Combining positron emission tomography/computed tomography (PET/CT) before-NST and the MARI (marking axillary lymph nodes with radioactive iodine seeds) procedure after neoadjuvant systemic therapy (NST) has the potential for avoiding unnecessary ALNDs. This report presents the results from implementation of this strategy. METHODS: All breast cancer patients treated with NST at the Netherlands Cancer Institute who underwent a PET/CT and the MARI procedure from July 2014 to July 2017 were included in the study...
June 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29476570/does-the-presence-of-sentinel-lymph-node-macrometastases-in-breast-cancer-patients-require-axillary-lymph-node-dissection-single-center-analysis
#15
Tomasz Nowikiewicz, Wojciech Zegarski, Konrad Pagacz, Maciej Nowacki, Alina Morawiec-Sztandera, Iwona Głowacka-Mrotek, Magdalena Sowa, Marta Biedka, Agnieszka Kołacińska
According to the current guidelines on treatment of breast cancer patients, identification of metastases in the sentinel lymph node (SLN (+)) is not an absolute indication for necessary axillary lymph node dissection (ALND). In our study, we present long-term outcomes of treatment among SLN(+) patients referred for conservative treatment, for example, no further ALND. A total of 3145 breast cancer patients subjected to sentinel lymph node biopsy (SLNB) between November 2008 and June 2015. SLN metastases were identified in 719 patients (22...
February 24, 2018: Breast Journal
https://www.readbyqxmd.com/read/29468606/repeat-sentinel-lymph-node-biopsy-for-ipsilateral-breast-tumor-recurrence-a-systematic-review-of-the-results-and-impact-on-prognosis
#16
Ingrid G M Poodt, Guusje Vugts, Robert-Jan Schipper, Grard A P Nieuwenhuijzen
BACKGROUND: During recent years, an increasing number of patients with ipsilateral breast tumor recurrence (IBTR) and previous axillary surgery have undergone repeat sentinel lymph node biopsy (rSLNB). The influence of axillary nodal status on prognosis for IBTR patients remains unclear. This study aimed to evaluate the technical success rate, follow-up assessment, and prognostic value of rSLNB for patients with IBTR. METHODS: A systematic search conducted in MEDLINE, Embase, and the Cochrane Library up to July 2017 included all studies on rSLNB in IBTR...
May 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29455041/is-osna-better-than-imprint-cytology-for-intraoperative-diagnosis-of-cancer-involvement-of-axillary-sentinel-node-in-breast-cancer
#17
M A Luna-Tomás, M Solà-Suárez, A Mariscal-Martínez, E Castellà-Fernández, S Martínez-Román, I Pascual-Miguel, V Quiroga-García, J F Julián-Ibáñez
OBJECTIVE: The study aim was to establish Sensitivity, Specificity, Positive Predictive Value, Negative Predictive Value (NPV), and Accuracy Values of both imprint cytology (IC) and the OSNA assay for intraoperative assessment of axillary sentinel node (SN) cancer involvement in breast cancer. Specifically, we wished to find out if true positive and false negative results of IC were associated to axillary lymphadenectomy (ALND). Also, we addressed a comparative cost analysis between techniques...
April 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29443748/ultrasound-combined-with-fine-needle-aspiration-cytology-for-the-assessment-of-axillary-lymph-nodes-in-patients-with-early-stage-breast-cancer
#18
Fan Zhang, Jing Zhang, Qing-Xin Meng, Xin Zhang
This study aimed to explore the clinical usefulness of ultrasound-guided fine needle aspiration cytology (USG-FNAC) for the evaluation of axillary lymph nodes in patients with early stage breast cancer (BC) among the Chinese Han female population.Around 124 patients with early stage BC were included in this retrospective study. All patients underwent USG-FNAC (group A). Patients with proven metastasis also underwent axillary lymph node dissection (ALND) (group B). In addition, sentinel lymph node biopsy (SLNB) was performed 2 to 5 hours prior to the surgery...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29441833/role-of-number-of-sentinel-nodes-in-predicting-non-sentinel-node-metastasis-in-breast-cancer
#19
Li-Feng Dong, Shu-Ying Xu, Jing-Pei Long, Fang Wan, Yi-Ding Chen
Objective The aim of the present study was to determine how many sentinel lymph nodes (SLNs) are appropriate for predicting non-SLN metastasis in breast cancer. Methods The association between clinicopathological features and non-SLN metastasis was retrospectively analyzed in 472 patients who underwent axillary lymph node dissection (ALND) following SLN biopsy. Another 251 patients who underwent only SLN biopsy without ALND were analyzed and followed up for 2 years. Results A large tumor size, positive SLN, and HER-2 positivity were independent predictors of non-SLN metastasis...
February 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29439780/evolving-imaging-techniques-for-staging-axillary-lymph-nodes-in-breast-cancer
#20
REVIEW
S Lowes, A Leaver, K Cox, K Satchithananda, D Cosgrove, A Lim
The presence and extent of axillary nodal metastases at the time of breast cancer diagnosis is a critical factor in disease prognosis and plays a central role in deciding the best treatment for patients. Accurate assessment of the axilla is therefore an essential component in staging breast cancer. Over the years, axillary staging has evolved from surgical axillary lymph node dissection (ALND), with its numerous associated long-term complications, to the much less-radical surgical sentinel lymph node excision biopsy (SLNB), the current reference standard...
April 2018: Clinical Radiology
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