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Epicatechin

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https://www.readbyqxmd.com/read/28428087/searching-for-new-sources-of-innovative-products-for-the-food-industry-within-halophyte-aromatic-plants-in-vitro-antioxidant-activity-and-phenolic-and-mineral-contents-of-infusions-and-decoctions-of-crithmum-maritimum-l
#1
Catarina Guerreiro Pereira, Luísa Barreira, Nuno da Rosa Neng, José Manuel Florêncio Nogueira, Cátia Marques, Tamára F Santos, João Varela, Luísa Custódio
Aromatic halophyte plants are an outstanding source of bioactive compounds and natural products with potential use in the food industry. This work reports the in vitro antioxidant activity, toxicity, polyphenolic profile and mineral contents of infusions and decoctions from stems, leaves and flowers of Crithmum maritimum L., an aromatic and edible maritime halophyte (sea fennel). Aspalathus linearis (Burm.f.) Dahlg. (rooibos) herbal tea was used as a reference. Sea fennel's tisanes, particularly from leaves, were rich in phenolic compounds and five of them (p-hydroxybenzoic and ferulic acids, epicatechin, pyrocatechol and 4-hydroxybenzaldehyde) were here described in C...
April 17, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28428085/galloylation-of-polyphenols-alters-their-biological-activity
#2
REVIEW
Daniel Karas, Jitka Ulrichová, Kateřina Valentová
Polyphenols form one of the largest groups of natural compounds and possess a wide range of biological properties. These activities can be influenced by the galloyl moiety within their structures. A multitude of galloylated polyphenolic compounds occurs in nature, but galloylated phenols are also produced synthetically to influence their biological properties. This review provides a comprehensive summary of current knowledge about natural (galloylated catechins, theaflavins and proanthocyanidins, penta-O-galloyl-β-D-glucose, gallotannins, ellagitannins, ellagic acid and flavonols) and semisynthetic gallates with a focus on their biological activity and toxicity issues...
April 17, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28427650/effect-of-ultrasound-on-the-interaction-between-epicatechin-gallate-and-bovine-serum-albumin-in-a-model-wine
#3
Qing-An Zhang, Xi-Zhe Fu, Juan Francisco García Martín
Ultrasound is considered as a potential novel technique for improving the quality of some wines. In this paper, a model wine firstly was constructed with the standards of (-)-epicatechin gallate (ECG) and bovine serum albumin (BSA) as target compounds. Then, the experiments were conducted to investigate the effect of ultrasonic irradiation on the binding properties between ECG and BSA including quenching mechanism, binding parameters, binding forces, energy transfer distance and conformational changes determined by spectral analysis...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28422543/newer-insights-into-the-antidiarrheal-effects-of-acacia-catechu-willd-extract-in-guinea-pig
#4
Matteo Micucci, Roberto Gotti, Ivan Corazza, Gabriella Tocci, Alberto Chiarini, Marta De Giorgio, Luca Camarda, Maria Frosini, Carla Marzetti, Monica Cevenini, Roberta Budriesi
Acacia catechu Willd. is a plant diffused in India and other Asian countries, where it is used as a traditional medicine for the treatment of several ailments including diarrhea, one of the most common pathologies worldwide. In this study, we determined the chemical composition of Acacia catechu Willd. extract (AC) and evaluated its effect on spontaneous and induced contractility in isolated guinea pig ileum and proximal colon. Preliminary data about its antimicrobial effect against some pathogen agents versus some microbiota intestinal strain have been also reported...
April 19, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28422181/antioxidant-synergistic-effects-of-osmanthus-fragrans-flowers-with-green-tea-and-their-major-contributed-antioxidant-compounds
#5
Shuqin Mao, Kaidi Wang, Yukun Lei, Shuting Yao, Baiyi Lu, Weisu Huang
The antioxidant synergistic effects of Osmanthus fragrans flowers with green tea were evaluated, and their major antioxidant compounds contributed to the total amount of synergy were determined. The antioxidant compounds in O. fragrans flowers with green tea were identified by LC-MS and quantified by UPLC-PDA. The synergistic antioxidant interactions between O. fragrans flowers with green tea and their antioxidant compounds were tested using the Prieto's model after the simulated digestion. The main antioxidant compounds in O...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28421745/molecular-approach-of-the-synergistic-effect-on-astringency-elicited-by-mixtures-of-flavanols
#6
Alba M Ramos-Pineda, Ignacio García-Estévez, Natércia Fernandes Brás, Eva M Martin Del Valle, Montserrat Duenas, M Teresa Escribano-Bailon
The interactions between salivary proteins and wine flavanols (catechin, epicatechin and mixtures catechin+epicatechin) have been studied by HPLC-DAD, Isothermal Titration Microcalorimetry and Molecular Dynamics simulations. Chromatographic results suggest that the presence of these flavanol mixtures could facilitate the formation of precipitates to the detriment of soluble aggregates. The comparison between the thermodynamic parameters obtained showed remarkable higher negative values of ΔG in the system containing the mixture of both flavanols in comparison to the systems containing individual flavanols, indicating a more favourable scenario in the mixing system...
April 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28420000/-epicatechin-suppresses-angiotensin-ii-induced-cardiac-hypertrophy-via-the-activation-of-the-sp1-sirt1-signaling-pathway
#7
Zeng-Xiang Dong, Lin Wan, Ren-Jun Wang, Yuan-Qi Shi, Guang-Zhong Liu, Si-Jia Zheng, Hui-Ling Hou, Wei Han, Xin Hai
BACKGROUND/AIMS: Flavonol (-)-epicatechin (EPI) is present in high amounts in cocoa and tea products, and has been shown to exert beneficial effects on the cardiovascular system. However, the precise mechanism of EPI on cardiomyocyte hypertrophy has not yet been determined. In this study, we examined whether EPI could inhibit cardiac hypertrophy. METHODS: We utilised cultured neonatal mouse cardiomyocytes and mice for immunofluorescence, immunochemistry, qRT-PCR, and western blot analyses...
April 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28416859/effect-of-catechin-and-its-derivatives-on-inhibition-of-polyphenoloxidase-and-melanosis-of-pacific-white-shrimp
#8
Thanasak Sae-Leaw, Soottawat Benjakul, Benjamin K Simpson
This study aimed to investigate the effect of tea catechin (C) and 4 of its derivatives on the Pacific white shrimp PPO inhibition and melanosis during refrigerated storage. Epigallocatechin gallate (EGCG) exhibited the highest inhibition towards PPO, followed by C. Inhibitory activity of all compounds tested was in a dose dependent manner (0.1-2.0 mM). Based on activity staining, EGCG most effectively inhibited PPO. For inhibition kinetic studies, C and epicatechin (EC) showed uncompetitive type, whereas epicatechin gallate (ECG), epigallocatechin (EGC) and EGCG exhibited mixed type inhibition...
April 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28416754/unique-synergistic-formulation-of-curcumin-epicatechin-gallate-and-resveratrol-tricurin-suppresses-hpv-e6-eliminates-hpv-cancer-cells-and-inhibits-tumor-progression
#9
Sumit Mukherjee, Priya Ranjan Debata, Rahman Hussaini, Kaushiki Chatterjee, Juliet N E Baidoo, Samay Sampat, Anita Szerszen, Joseph P Navarra, Jimmie Fata, Elena Severinova, Probal Banerjee, Mario R Castellanos
Curcumin (from curry) (C) is highly potent against cervical cancer cells (CCC), but poor bioavailability has limited its clinical use. Similar natural polyphenols resveratrol (from grapes) (R), and epicatechin gallate (from green tea) (E) also display activity against CCC. By treating CCC (HeLa) with C, E, or R, or combinations of these compounds, we computed combination indices and observed a strong synergism among C, E, and R at the unique molar ratio 4:1:12.5. This combination, named as TriCurin, rapidly down regulated HPV18 E6 and NF-kB expression while concomitantly inducing the tumor suppressor protein p53 in HeLa cells...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28416338/separation-and-purification-of-polyphenols-from-red-wine-extracts-using-high-speed-counter-current-chromatography
#10
Yuanyuan Li, Lingxi Li, Yan Cui, Shuting Zhang, Baoshan Sun
Polyphenols are important compounds of red wine owing to their contribution to sensory properties and antioxidant activities. In this study, high-speed counter-current chromatography (HSCCC) coupled with semi-preparative HPLC was used for large-scale separation and purification of polyphenols from red wine extracts. With the solvent system of hexane-ethyl acetate-water (1-50-50), various oligomeric procyanidins including monomer catechin, epicatechin, dimers B1, B2; phenolic acids including coutaric acid, caftaric acid and other type of polyphenols were largely separated within 370min and most of these compounds presented high yields (0...
March 12, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28414437/phenolic-content-and-antioxidant-activity-during-the-development-of-brookfield%C3%A2-and-mishima-apples
#11
Mayara C Stanger, Cristiano A Steffens, Cristina Soethe, Marcelo A Moreira, Cassandro V T do Amarante
The aim of this study was to characterize the changes in the contents of total (TPC) and individual (IPC) phenolic compounds and the total antioxidant activity (TAA) in the peel and pulp, and total anthocyanins (TAN) in the peel, during the development of the fruits of Brookfield® and Mishima apple trees. 'Brookfield®' apples were harvested from the 49th to 138th days after full bloom (DAFB) and 'Mishima' apples from the 45th to 172th DAFB. In the pulp, the IPC, TPC and TAA rapidly reduced at 75 and 79 DAFB for the 'Brookfield®' and 'Mishima' apples, respectively, and then remained constant until commercial maturity...
April 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28411462/flavone-polyphenols-dominate-in-thymus-schimperi-ronniger-lc-esi-ms-ms-characterization-and-study-of-anti-proliferative-effects-of-plant-extract-on-ags-and-hepg2-cancer-cells
#12
Kebede Taye Desta, Gon Sup Kim, A M Abd El-Aty, Suchismita Raha, Man-Bae Kim, Ji Hoon Jeong, Mohamad Warda, Ahmet Hacımüftüoğlu, Ho-Chul Shin, Jae-Han Shim, Sung Chul Shin
Thymus schimperi is a highly localized and a rare plant endemic to Ethiopia. An optimized and validated high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS) method was applied to characterize 23 polyphenolic compounds found in ethyl acetate extracts of the plant. From those, flavones dominated and luteolin was the major component contributing 21.83% of the total composition (or 46.05±0.59g/kg of fresh sample weight). Validation data showed a determination coefficient (R(2))≥0...
March 31, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28407923/simultaneous-separation-and-purification-of-chlorogenic-acid-epicatechin-hyperoside-and-phlorizin-from-thinned-young-qinguan-apples-by-successive-use-of-polyethylene-and-polyamide-resins
#13
Lijun Sun, Dongjie Liu, Jiaojiao Sun, Xingbin Yang, Minghai Fu, Yurong Guo
The method for separating and purifying chlorogenic acid (CA), epicatechin (EC), hyperoside (HY) and phlorizin (PH) simutaneously from young Qinguan apples by successive use of X-5 and polyamide resins has been developed in this study. The order of adsorption capacities of X-5 for the four phenolics was PH>HY>EC>CA, and the adsorption equilibriums of the four phenolics onto X-5 resin conformed to Langmuir isotherms preferentially. The adsorption kinetics of EC and CA onto X-5 conformed to the pseudo-first-order model, while that of HY and PH accorded with the pseudo-second-order model...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28395820/characterization-and-quantification-of-fruit-phenolic-compounds-of-european-and-tunisian-pear-cultivars
#14
Marwa Brahem, Catherine M G C Renard, Severin Eder, Michèle Loonis, Rim Ouni, Messaoud Mars, Carine Le Bourvellec
The flesh and peel of 19 pear cultivars (8 Tunisian dessert cultivars, 8 European dessert cultivars and 3 French perry pear cultivars) were studied for their phenolic composition. Phenolic compounds were identified by HPLC/ESI-MS(2) and individually quantified by HPLC-DAD. Five classes of polyphenols were present: flavan-3-ols, phenolic acids, flavonols, anthocyanins and simple phenolics (hydroquinones). The total phenolic content ranged between 0.1g/kg Fresh Weight (FW) ('Conference' cultivar) and 8.6g/kg FW ('Plant De Blanc' cultivar) in the flesh and between 1...
May 2017: Food Research International
https://www.readbyqxmd.com/read/28391283/mothers-consumption-of-soy-drink-but-not-black-tea-increases-the-flavonoid-content-of-term-breast-milk-a-pilot-randomized-controlled-intervention-study
#15
Frank Jochum, Birgit Alteheld, Pamela Meinardus, Norbert Dahlinger, Antonia Nomayo, Peter Stehle
OBJECTIVE: We performed a pilot RCT to prove the hypothesis that a controlled ingestion of polyphenol-rich beverages (soy drink, decaffeinated black tea) in nutritive dosages by nursing women has an effect on the composition (flavonoid concentration, total antioxidant capacity) of breast milk. METHODS: Healthy nursing women were supplemented with either 250 mL of a soy drink (12 mg isoflavones; n = 18), 300 mL decaffeinated black tea (67 mg catechins; n = 18), or 300 mL water (n = 8, control) for 6 days...
April 8, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28384253/epicatechin-elicits-myod-dependent-myoblast-differentiation-and-myogenic-conversion-of-fibroblasts
#16
Sang-Jin Lee, Young-Eun Leem, Ga-Yeon Go, Younhee Choi, Yoo Jin Song, Insol Kim, Do Yoon Kim, Yong Kee Kim, Dong-Wan Seo, Jong-Sun Kang, Gyu-Un Bae
Prevention of age-associated reduction in muscle mass and function is required to manage a healthy life. Supplemental (-)-Epicatechin (EC) appears to act as a potential regulator for muscle growth and strength. However, its cellular and molecular mechanisms as a potential muscle growth agent have not been studied well. In the current study, we investigated a role of EC in differentiation of muscle progenitors to gain the molecular insight into how EC regulates muscle growth. EC enhanced myogenic differentiation in a dose-dependent manner through stimulation of promyogenic signaling pathways, p38MAPK and Akt...
2017: PloS One
https://www.readbyqxmd.com/read/28383067/the-proposed-biosynthesis-of-procyanidins-by-the-comparative-chemical-analysis-of-five-camellia-species-using-lc-ms
#17
Liang Zhang, Yuling Tai, Yijun Wang, Qilu Meng, Yunqiu Yang, Shihua Zhang, Hua Yang, Zhengzhu Zhang, Daxiang Li, Xiaochun Wan
The genus Camellia (C.) contains many species, including C. sinensis, C. assamica, and C. taliensis, C. gymnogyna and C. tachangensis. The polyphenols of C. sinensis and C. assamica are flavan-3-ols monomers and their dimers and trimmers. However, the biosynthesis of procyanidins in Camellia genus remains unclear. In the present study, a comparative chemical analysis of flavan-3-ols, flavan-3-ols glycoside and procyanidins was conducted by high performance liquid chromatography (HPLC) and liquid chromatography diode array detection coupled with triple-quadrupole mass-spectrometry (LC-DAD-QQQ-MS)...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28375126/tyrosinase-inhibition-anti-acetylcholinesterase-and-antimicrobial-activities-of-the-phytochemicals-from-gynotroches-axillaris-blume
#18
Salam Ahmed Abed, Hasnah Mohd Sirat, Muhammad Taher
The leaves of Gynotroches axillaris were chemically and biologically studied. Sequential extraction of the leaves using petroleum ether, chloroform, and methanol afforded three extracts. Purification of pet. ether extract yielded, squalene and β-amyrin palmitate as the major compounds, together with palmitic acid and myristic acid as the minor components. The methanol extract yielded two flavonoids, quercitrin and epicatechin. The isolated compounds were characterized by MS, IR and NMR (1D and 2D). Anti-acetyl cholinesterase screening using TLC bio-autography assay showed that palmitic acid and myristic acid were the strongest inhibition with detection limit 1...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28372473/selection-of-chemical-markers-for-the-quality-control-of-medicinal-plants-of-the-genus-cecropia
#19
Andrés Rivera-Mondragón, Orlando O Ortíz, Sebastiaan Bijttebier, Arnold Vlietinck, Sandra Apers, Luc Pieters, Catherina Caballero-George
CONTEXT: Several Cecropia (Cecropiaceae) species are traditionally used in Latin America for the treatment of a variety of diseases including diabetes, arterial hypertension, asthma, bronchitis, anxiety, and inflammation. At present, a number of commercial products based on these plants have been introduced into the market with very little information on methods for guaranteeing their quality and safety. OBJECTIVE: This work proposes potential chemical markers for the quality control of the raw materials of Cecropia obtusifolia Bertol...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28372251/chlorogenic-acid-anthocyanin-and-flavan-3-ol-biosynthesis-in-flesh-and-skin-of-andean-potato-tubers-solanum-tuberosum-subsp-andigena
#20
Matías Ariel Valiñas, María Luciana Lanteri, Arjen Ten Have, Adriana Balbina Andreu
Natural variation of Andean potato was used to study the biosynthesis of phenolic compounds. Levels of phenolic compounds and corresponding structural gene transcripts were examined in flesh and skin of tubers. Phenolic acids, mainly chlorogenic acid (CGA), represent the major compounds, followed by anthocyanins and flavan-3-ols. High-anthocyanin varieties have high levels of CGA. Both metabolite and transcript levels were higher in skin than in flesh and showed a good correspondence. Two hydroxycinnamoyl-CoA transferases (HCT/HQT) have been involved in CGA production, of which HCT reflects CGA levels...
August 15, 2017: Food Chemistry
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