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Epicatechin

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https://www.readbyqxmd.com/read/28639145/in-vitro-and-in-vivo-activity-of-theaflavin-epicatechin-combinations-versus-multidrug-resistant-acinetobacter-baumannii
#1
Jonathan W Betts, Michael Hornsey, David W Wareham, Roberto M La Ragione
INTRODUCTION: Acinetobacter baumannii is an important human nosocomial pathogen; most clinical isolates are multidrug-resistant (MDR). Infections caused by A. baumannii often lead to high morbidity and mortality, with limited treatment options. Owing to the small number of anti-Gram-negative antibiotics in the development pipeline, researchers are looking to other natural compounds. The aim of this study was to determine the in vitro kill kinetics, in vivo efficacy and toxicity of theaflavin-epicatechin combinations against MDR A...
June 21, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/28638763/the-hidden-face-of-wine-polyphenol-polymerization-highlighted-by-high-resolution-mass-spectrometry
#2
Anna Vallverdú-Queralt, Emmanuelle Meudec, Matthias Eder, Rosa M Lamuela-Raventos, Nicolas Sommerer, Véronique Cheynier
Polyphenols, including tannins and red anthocyanin pigments, are responsible for the color, taste, and beneficial health properties of plant-derived foods and beverages, especially in red wines. Known compounds represent only the emerged part of the "wine polyphenol iceberg". It is believed that the immersed part results from complex cascades of reactions involving grape polyphenols and yeast metabolites. We used a non-targeted strategy based on high-resolution mass spectrometry and Kendrick mass defect plots to explore this hypothesis...
June 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28635261/novel-protein-based-solid-biosensor-for-determining-pro-oxidant-activity-of-phenolic-compounds
#3
Esin Akyüz, Kevser Sözgen Başkan, Esma Tütem, Reşat Apak
To develop a protein‒based biosensor measuring the pro-oxidant activities of phenolic compounds, egg white proteins were precipitated with calcium chloride to obtain an insoluble calcium proteinate complex. This biosensor was used for the determination of Cu(II)‒induced pro-oxidant activity of antioxidants such as gallic acid, catechin, epicatechin, quercetin, chlorogenic acid and myricetin, and ascorbic acid. This assay involved the reduction of Cu(II) ions to Cu(I) by antioxidant compounds (simultaneously giving rise to reactive oxygen species) and binding of the formed Cu(I) to the solid biosensor...
June 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28633497/genome-wide-identification-and-functional-characterization-of-udp-glucosyltransferase-genes-involved-in-flavonoid-biosynthesis-in-glycine-max
#4
Qinggang Yin, Guoan Shen, Shaokang Di, Cunying Fan, Zhenzhan Chang, Yongzhen Pang
Flavonoids, natural products abundant in the model legume Glycine max, confer benefits to plants and animals health. Flavonoids are present in soybean mainly as glycoconjugates. However, the biosynthesis mechanisms of flavonoid glycosides are largely unknown in G. max. In the present study, 212 putative UDP-glycosyltransferase (UGTs) genes were identified in G. max by genome-wide searching. The GmUGT genes were distributed differentially among the twenty chromosomes, and they were expressed in various tissues with distinct expression profile...
June 19, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28629860/hydrogen-deuterium-exchange-kinetics-in-%C3%AE-lactoglobulin-epicatechin-complexes-studied-by-ftir-spectroscopy
#5
Francesca Caporaletti, Marina Carbonaro, Paola Maselli, Alessandro Nucara
Hydrogen-Deuterium exchange kinetics of of β-lactoglobulin and β-lactoglobulin (-)-epicatechin solutions has been investigated through the analysis of the amide I absorption band at 1650cm(-1) in the FTIR spectrum. H-D substitution in NH amides and residues of the protein results in a slight red-shift and in intensity changes of the amide I components: either these effects have been inspected in the framework of the Principal Components Analysis methods. The present analysis allowed to unveil three H-D kinetics at the timescale of the oligomeric fluctuations of the protein...
June 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28625836/molecular-interaction-studies-of-acetylcholinesterase-with-potential-acetylcholinesterase-inhibitors-from-the-root-of-rhodiola-crenulata-using-molecular-docking-and-isothermal-titration-calorimetry-methods
#6
Fa-Jie Li, Yuan Liu, Yuan Yuan, Bin Yang, Zhen-Ming Liu, Lu-Qi Huang
(-)-Epicatechin gallate ((-)-ECG), 1,2,3,4,6-O-pentagalloylglucose (PGG), rhodionin, herbacetin and rhodiosin isolated from the root of Rhodiola crenulata exhibited potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC50 ranged from 57.50±5.83 to 2.43±0.34μg/mL. With the aim of explaining the differences in activity of these active ingredients and clarifying how they inhibit AChE, the AChE-inhibitor interactions were further explored using molecular docking and isothermal titration calorimetry (ITC) methods in the present study...
June 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28613901/characterization-of-phenolic-compounds-from-early-and-late-ripening-sweet-cherries-and-their-antioxidant-and-antifungal-activities
#7
Meng Wang, Nan Jiang, Yao Wang, Dongmei Jiang, Xiaoyuan Feng
Early and late ripening sweet cherries were characterized for phenolic acids, and also their antioxidant capacity and potential antifungal effects were investigated. Free, conjugated and bound phenolics were identified and quantified using UPLC-MS/MS. Our results indicated that the early ripening cultivars contained higher free phenolic, which positive related to remarkable antioxidant properties and the inhibition effects on A. alternata and tenuazonic acid (TeA) accumulation. However, conjugated phenolics of the late ripening cultivars, mainly including caffeic, 2, 3, 4-trihydroxybenzoic, p-coumaric and pyrocatechuic acids, achieved the highest antifungal effects, and almost completely inhibited the A...
June 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28610737/the-impact-of-wine-components-on-fractionation-of-cu-and-fe-in-model-wine-systems-macromolecules-phenolic-and-sulfur-compounds
#8
Nikolaos Kontoudakis, Mark Smith, Anque Guo, Paul A Smith, Geoffrey R Scollary, Eric N Wilkes, Andrew C Clark
A variety of techniques have been developed with the ability to measure different forms of metals in wine with the ultimate aim of providing a more accurate indicator of metal induced spoilage of wine. This study was conducted in order to identify which wine components influence the measurement of Cu and Fe in their fractionated and/or electrochemically active forms. The measurement techniques involved detection of labile Cu by stripping potentiometry and fractionation of Cu and Fe by sequential solid phase extraction, with detection by inductively coupled plasma-optical emission spectroscopy...
August 2017: Food Research International
https://www.readbyqxmd.com/read/28608836/evaluation-of-the-antidiabetic-activity-and-chemical-composition-of-geranium-collinum-root-extracts-computational-and-experimental-investigations
#9
Sodik Numonov, Salamet Edirs, Khayrulla Bobakulov, Muhammad Nasimullah Qureshi, Khurshed Bozorov, Farukh Sharopov, William N Setzer, Haiqing Zhao, Maidina Habasi, Mizhgona Sharofova, Haji Akber Aisa
The root of Geranium collinum Steph is known in Tajik traditional medicine for its hepatoprotective, antioxidant, and anti-inflammatory therapeutic effects. The present study was conducted to evaluate of potential antidiabetic, antioxidant activities, total polyphenolic and flavonoid content from the different extracts (aqueous, aqueous-ethanolic) and individual compounds isolated of the root parts of G. collinum. The 50% aqueous-ethanolic extract possesses potent antidiabetic activity, with IC50 values of 0...
June 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28607618/catechin-and-epicatechin-reduce-mitochondrial-dysfunction-and-oxidative-stress-induced-by-amiodarone-in-human-lung-fibroblasts
#10
Luciana Fernandes Silva Santos, Adriana Stolfo, Caroline Calloni, Mirian Salvador
BACKGROUND: Amiodarone (AMD) and its metabolite N-desethylamiodarone can cause some adverse effects, which include pulmonary toxicity. Some studies suggest that mitochondrial dysfunction and oxidative stress may play a role in these adverse effects. Catechin and epicatechin are recognized as important phenolic compounds with the ability to decrease oxidative stress. Therefore, the aim of this study was to evaluate the potential of catechin and epicatechin to modulate mitochondrial dysfunction and oxidative damage caused by AMD in human lung fibroblast cells (MRC-5)...
June 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28605979/phytochemical-investigation-of-rumex-thyrsiflorus-fingerh
#11
Orsolya Orbán-Gyapai, Peter Forgo, Judit Hohmann, Andrea Vasas
In the course of our pharmacological screening of Polygonaceae species occurring in the Carpathian Basin the extracts prepared from the roots of Rumex thyrsiflorus showed promising antiproliferative, xanthine oxidase inhibitory and antibacterial activities. The present work deals with the isolation of compounds from the root of the plant. After multistep separation process, four compounds were obtained from the n-hexane, chloroform and ethyl acetate soluble fractions of the methanol extract of the root. The structures of the isolated compounds were determined as 1-palmitoylglycerol, β-sitosterol, (-)-epicatechin, and procyanidin B5...
June 2017: Acta Biologica Hungarica
https://www.readbyqxmd.com/read/28597441/accumulation-of-catechins-and-expression-of-catechin-synthetic-genes-in-camellia-sinensis-at-different-developmental-stages
#12
Li-Qun Zhang, Kang Wei, Hao Cheng, Li-Yuan Wang, Cheng-Cai Zhang
BACKGROUND: Catechins are the main polyphenol compounds in tea (Camellia sinensis). To understand the relationship between gene expression and product accumulation, the levels of catechins and relative expressions of key genes in tea leaves of different developmental stages were analyzed. RESULTS: The amounts of catechins differed significantly in leaves of different stages, except for gallocatechin gallate. Close correlations between the expression of synthesis genes and the accumulation of catechins were identified...
December 2016: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/28593026/corrigendum-to-epicatechin-prevents-blood-pressure-increase-and-reduces-locomotor-hyperactivity-in-young-spontaneously-hypertensive-rats
#13
M Kluknavsky, P Balis, A Puzserova, J Radosinska, A Berenyiova, M Drobna, S Lukac, J Muchova, I Bernatova
[This corrects the article DOI: 10.1155/2016/6949020.].
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28590446/fruits-of-black-chokeberry-aronia-melanocarpa-in-the-prevention-of-chronic-diseases
#14
REVIEW
Tunde Jurikova, Jiri Mlcek, Sona Skrovankova, Daniela Sumczynski, Jiri Sochor, Irena Hlavacova, Lukas Snopek, Jana Orsavova
In recent years, growing attention has been focused on the utilization of natural sources of antioxidants in the prevention of chronic diseases. Black chokeberry (Aronia melanocarpa) represents a lesser known fruit species utilized mainly as juices, purees, jams, jellies and wine, as important food colorants or nutritional supplements. The fruit is valued as a great source of antioxidants, especially polyphenols, such as phenolic acids (neochlorogenic and chlorogenic acids) and flavonoids (anthocyanins, proanthocyanidins, flavanols and flavonols), particularly cyanidin-3-galactoside and cyanidin-3-arabinoside, as well as (-)-epicatechin units...
June 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28590304/antinociceptive-effect-of-epicatechin-in-inflammatory-and-neuropathic-pain-in-rats
#15
Geovanna N Quiñonez-Bastidas, Jorge B Pineda-Farias, Francisco J Flores-Murrieta, Juan Rodríguez-Silverio, Juan G Reyes-García, Beatriz Godínez-Chaparro, Vinicio Granados-Soto, Héctor I Rocha-González
The aim of this study was to investigate the antinociceptive potential of (-)-epicatechin and the possible mechanisms of action involved in its antinociceptive effect. The carrageenan and formalin tests were used as inflammatory pain models. A plethysmometer was used to measure inflammation and L5/L6 spinal nerve ligation as a neuropathic pain model. Oral (-)-epicatechin reduced carrageenan-induced inflammation and nociception by about 59 and 73%, respectively, and reduced formalin- induced and nerve injury-induced nociception by about 86 and 43%, respectively...
June 5, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28587348/hepatoprotective-effects-of-litchi-litchi-chinensis-procyanidin-a2-on-carbon-tetrachloride-induced-liver-injury-in-icr-mice
#16
Lih-Geeng Chen, Cheng-Wei Chang, Jwu-Guh Tsay, Brian Bor-Chun Weng
Drug tolerance, lacking liver regenerative activity and inconclusive inhibition of steatosis and cirrhosis by silymarin treatment during chronic liver injury have increased the demand for novel alternative or synergistic treatments for liver damage. Litchi fruit is abundant in polyphenolic compounds and is used in traditional Chinese medicine for treatments that include the strengthening of hepatic and pancreatic functions. Unique polyphenolic compounds obtained from litchi pericarp extract (LPE) were studied in vitro and in vivo for hepatoprotection...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28587132/anti-inflammatory-activity-of-a-polymeric-proanthocyanidin-from-serjania-schiedeana
#17
David Osvaldo Salinas-Sánchez, Enrique Jiménez-Ferrer, Veronica Sánchez-Sánchez, Alejandro Zamilpa, Manasés González-Cortazar, Jaime Tortoriello, Maribel Herrera-Ruiz
The ethyl acetate extract (SsAcOEt) from Serjania schiedeana, select fractions (F-6, F-12, F-13, F-14), and one isolated compound, were evaluated in 12-O-tetradecanoylphorbol 13-acetate (TPA) ear edema and kaolin/carrageenan (KC)-induced monoarthritis assays. SsEtOAc induced edema inhibition of 90% (2.0 mg/ear), fractions showed activity within a range of 67-89%. Due to the fact F-14 showed the highest effect, it was separated, yielding a proanthocyanidin-type called epicatechin-(4β → 8)-epicatechin-(4β → 8, 2β → O → 7) epicatechin (ETP)...
May 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28584491/evaluation-of-cassia-tora-linn-against-oxidative-stress-induced-dna-and-cell-membrane-damage
#18
R Sunil Kumar, Ramesh Balenahalli Narasingappa, Chandrashekar G Joshi, Talakatta K Girish, Ummiti Js Prasada Rao, Ananda Danagoudar
OBJECTIVE: The present study aims to evaluate antioxidants and protective role of Cassia tora Linn. against oxidative stress-induced DNA and cell membrane damage. MATERIALS AND METHODS: The total and profiles of flavonoids were identified and quantified through reversed-phase high-performance liquid chromatography. In vitro antioxidant activity was determined using standard antioxidant assays. The protective role of C. tora extracts against oxidative stress-induced DNA and cell membrane damage was examined by electrophoretic and scanning electron microscopic studies, respectively...
January 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28584397/a-comparative-study-of-the-inhibitory-effects-by-caffeic-acid-catechins-and-their-related-compounds-on-the-generation-of-radicals-in-the-reaction-mixture-of-linoleic-acid-with-iron-ions
#19
Yuji Matsui, Yoshie Tanaka, Hideo Iwahashi
Caffeic acid and (+)-catechin, which are abundantly contained in coffee and tea, are typical polyphenols. In order to know the relative magnitudes of antioxidant activity, effects by caffeic acid, (+)-catechin and their derivatives on the formation of 4-POBN/carbon-centered linoleic acid-derived radical adducts were examined in the control reaction mixture of linoleic acid with FeCl3 at 30°C for 168 h. In the presence of 1.0 mM of the polyphenols, peak to peak heights of the third ESR signal resulted in 7...
May 2017: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/28576408/browning-effects-of-epicatechin-on-adipocytes-and-white-adipose-tissue
#20
Claudia Elena Varela, Alonso Rodriguez, Mirza Romero-Valdovinos, Patricia Mendoza-Lorenzo, Christina Mansour, Guillermo Ceballos, Francisco Villarreal, Israel Ramirez-Sanchez
In this study, we demonstrate that (-)-epicatechin (Epi), a cacao flavanol, induces the browning of fat by promoting mitochondrial biogenesis, enhancing indicators of mitochondrial structure and function, increasing fatty acid metabolism and upregulating the expression of brown adipose tissue-specific proteins in a high-fat diet mouse model of obesity and in cultured human adipocytes. Epi treatment significantly improved mitochondrial function, as measured by citrate synthase activity, and also reduced protein acetylation of total and specific regulators in both adipose tissue and human adipocytes...
May 30, 2017: European Journal of Pharmacology
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