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Epicatechin

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https://www.readbyqxmd.com/read/28551220/control-of-anthracnose-disease-via-increased-activity-of-defence-related-enzymes-in-hass-avocado-fruit-treated-with-methyl-jasmonate-and-methyl-salicylate
#1
Marcin Glowacz, Nico Roets, Dharini Sivakumar
Development of anthracnose disease caused by Colletotrichum gloeosporioides Penz. is one of the major issues within the avocado supply chain. Exposure to methyl jasmonate (MeJA) and methyl salicylate (MeSA) vapours at 10 and 100µmoll(-1) was investigated as an alternative solution to commercial fungicide - prochloraz® that is currently being used by the industry. The incidence of anthracnose disease was found to be significantly reduced in 'Hass' avocado fruit treated with MeJA or MeSA vapours, especially at 100μmoll(-1)...
November 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28551116/a-novel-multi-purpose-enzymatic-system-and-procedures-for-the-rapid-fluorescent-determination-of-flavonoids-in-herbal-pharmaceuticals-and-plant-materials
#2
Irina Veselova, Liubov Malinina, Marina Barsukova, Anna Tokareva, Tatiana Buslova, Lidia Sokolova, Andrey Pirogov, Tatiana Shekhovtsova
The paper presents a novel multi-purpose enzymatic system and procedures for fluorescent determination of several flavonoids in herbal pharmaceuticals and plant materials after their enzyme-catalyzed oxidation by hydrogen peroxide and further derivatization with meso-1,2-diphenylethylenediamine. This system may be used for rapid (15-30min/20 samples) simultaneous screening of samples containing a certain flavonoid in a standard microplate, or as a HPLC detection system for analyzing plant extracts with uncertain composition...
August 15, 2017: Talanta
https://www.readbyqxmd.com/read/28546002/catechins-activate-muscle-stem-cells-by-myf5-induction-and-stimulate-muscle-regeneration
#3
A Rum Kim, Kyung Min Kim, Mi Ran Byun, Jun-Ha Hwang, Jung Il Park, Ho Taek Oh, Hyo Kyeong Kim, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Muscle weakness is one of the most common symptoms in aged individuals and increases risk of mortality. Thus, maintenance of muscle mass is important for inhibiting aging. In this study, we investigated the effect of catechins, polyphenol compounds in green tea, on muscle regeneration. We found that (-)-epicatechin gallate (ECG) and (-)-epigallocatechin-3-gallate (EGCG) activate satellite cells by induction of Myf5 transcription factors. For satellite cell activation, Akt kinase was significantly induced after ECG treatment and ECG-induced satellite cell activation was blocked in the presence of Akt inhibitor...
May 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28545670/inhibitory-mechanism-of-five-natural-flavonoids-against-murine-norovirus
#4
Dong Joo Seo, Changsun Choi
BACKGROUND: Human noroviruses (HuNoV), which are responsible for acute gastroenteritis, are becoming a serious public health concern worldwide. Since no effective antiviral drug or vaccine for HuNoV has been developed yet, some natural extracts and their active components have been investigated for their ability to inhibit noroviruses. However, their exact antiviral mechanisms have not been investigated. PURPOSE: This study was performed to investigate the expression of interferon (IFN)-α, IFN-λ, tumor necrosis factor-α (TNF-α), Mx, and zinc finger CCCH type antiviral protein 1 (ZAP), 2'-5' oligo (A) synthetase (OAS), and inducible nitric oxide synthase (iNOS) in RAW 264...
July 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28545577/proanthocyanidin-accumulation-and-transcriptional-responses-in-the-seed-coat-of-cranberry-beans-phaseolus-vulgaris-l-with-different-susceptibility-to-postharvest-darkening
#5
José A Freixas Coutin, Seth Munholland, Anjali Silva, Sanjeena Subedi, Lewis Lukens, William L Crosby, K Peter Pauls, Gale G Bozzo
BACKGROUND: Edible dry beans (Phaseolus vulgaris L.) that darken during postharvest storage are graded lower and are less marketable than their non-darkened counterparts. Seed coat darkening in susceptible genotypes is dependent upon the availability of proanthocyanidins, and their subsequent oxidation to reactive quinones. Mature cranberry beans lacking this postharvest darkening trait tend to be proanthocyanidin-deficient, although the underlying molecular and biochemical determinants for this metabolic phenomenon are unknown...
May 25, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28540171/flavanols-from-the-camellia-sinensis-var-assamica-and-their-hypoglycemic-and-hypolipidemic-activities
#6
Xin Wang, Quan Liu, Hongbo Zhu, Hongqing Wang, Jie Kang, Zhufang Shen, Ruoyun Chen
α-Glucosidase and lipase inhibitors play important roles in the treatment of hyperglycaemia and dyslipidemia. To identify novel naturally occurring inhibitors, a bioactivity-guided phytochemical research was performed on the pu-erh tea. One new flavanol, named (-)-epicatechin-3-O-(Z)-coumarate (1), and 16 known analogs (2-17) were isolated from the aqueous extract of the pu-erh tea. Their structures were determined by spectroscopic and chemical methods. Furthermore, the water extract of pu-erh tea and its fractions exhibited inhibitory activities against α-glucosidases and lipases in vitro; compound 15 showed moderate inhibitory effect against sucrase with an IC50 value of 32...
May 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28539715/antiprotozoal-antibacterial-and-antidiarrheal-properties-from-the-flowers-of-chiranthodendron-pentadactylon-and-isolated-flavonoids
#7
Fernando Calzada, Teresa Juárez, Normand García-Hernández, Miguel Valdes, Oscar Ávila, Lilian Yepez Mulia, Claudia Velázquez
BACKGROUND: Chiranthodendron pentadactylon Larreat. (Sterculiaceae) is a Mexican plant used in traditional medicine for the treatment of heart disease symptoms and infectious diarrhea. OBJECTIVE: To evaluate in vitro antiprotozoal and antibacterial activities and in vivo antidiarrheal activity from the flowers of C. pentadactylon using the extract, fractions, and major isolated flavonoids. MATERIALS AND METHODS: Bioassay-guided fractionation of the methanol extract of C...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28528103/addition-of-exogenous-enzymes-to-diets-containing-grape-pomace-effects-on-intestinal-utilization-of-catechins-and-antioxidant-status-of-chickens
#8
S Chamorro, A Viveros, A Rebolé, I Arija, C Romero, I Alvarez, A Rey, A Brenes
Grape pomace (GP) is a rich source of polyphenols with antioxidant capacity. An experiment was conducted to study the effect of GP phenolic compounds included at 5 and 10%, and the addition (individually or combined) of hydrolyzing enzymes (carbohydrase enzyme complex and tannase at 500ppm) on intestinal utilization of catechins and antioxidant status in broiler chickens. A diet supplemented with 200ppm of α-tocopheryl acetate was also used. Our findings demonstrate the capacity of chickens to digest the monomeric (catechin, epicatechin, gallic acid, and epicatechin-O-gallate) and dimeric (procyanidin B1 and procyanidin B2) catechins present in grape pomace...
June 2017: Food Research International
https://www.readbyqxmd.com/read/28522973/profiling-and-distribution-of-metabolites-of-procyanidin-b2-in-mice-by-uplc-dad-esi-it-tof-ms-n-technique
#9
Ying Xiao, Zhongzhi Hu, Zhiting Yin, Yiming Zhou, Taiyi Liu, Xiaoli Zhou, Dawei Chang
The metabolite profiles and distributions of procyanidin B2 were qualitatively described using UPLC-DAD-ESI-IT-TOF-MS(n) without help of reference standards, and a possible metabolic pathway was proposed in the present study. Summarily, 53 metabolites (24 new metabolites) were detected as metabolites of procyanidin B2, and 45 of them were tentatively identified. Twenty seven metabolites were assigned as similar metabolites of (-)-epicatechin by scission of the flavanol interflavanic bond C4-C8, including 16 aromatic metabolites, 5 conjugated metabolites, 3 ring-cleavage metabolites, and 2 phenylvalerolactone metabolites...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28515764/the-effect-of-epicatechin-on-oxidative-stress-and-mitochondrial-damage-induced-by-homocycteine-using-isolated-rat-hippocampus-mitochondria
#10
Fatemeh Shaki, Yaghoub Shayeste, Mohammad Karami, Esmaeil Akbari, Mahdi Rezaei, Ramin Ataee
Oxidative stress and mitochondrial dysfunction are the main suggested mechanisms for neurodegenerative diseases. In this study, we have evaluated the effects of epicatechin (EC) on mitochondrial damage induced by homocycteine (Hcy) using isolated rat hippocampus mitochondria in vivo. EC (50 mg/kg) was gavaged daily for a period of 10 days, starting 5 days prior to Hcy (0.5 μmol/μL) intra hippocampus injection in rats. Mitochondria were isolated from brain by different centrifuge techniques. Mitochondrial function was assayed by MTT test...
April 2017: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28515736/expression-of-key-structural-genes-of-the-phenylpropanoid-pathway-associated-with-catechin-epimerization-in-tea-cultivars
#11
Changsong Chen, Kang Wei, Liyuan Wang, Li Ruan, Hailin Li, Xiaogui Zhou, Zhenghe Lin, Ruiyang Shan, Hao Cheng
Catechin epimerization is an important factor affecting tea catechin compositions and thereby tea quality. However, a lack of tea germplasms with high non-epicatechins limits relative research. Here, a tea cultivar Y510 with high non-epicatechins was firstly reported and used for catechin and RNA sequencing (RNA-Seq) analysis. Results showed that the (-)-gallocatechin gallate and (+)-catechin (C) contents in Y510 were at least 136 and 6 times higher than those in Fudingdabaicha and 0306I, but the epicatechins (-)-epigallocatechin and (-)-epicatechin (EC) were significantly lower...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28497962/potential-of-polygonum-cuspidatum-root-as-an-antidiabetic-food-dual-high-resolution-%C3%AE-glucosidase-and-ptp1b-inhibition-profiling-combined-with-hplc-hrms-and-nmr-for-identification-of-antidiabetic-constituents
#12
Yong Zhao, Martin Xiaoyong Chen, Kenneth Thermann Kongstad, Anna Katharina Jäger, Dan Staerk
The worldwide increasing incidence of type 2 diabetes has fueled an intensified search for food and herbal remedies with preventive and/or therapeutic properties. Polygonum cuspidatum Siebold & Zucc. (Polygonaceae) is used as a functional food in Japan and South Korea, and it is also a well-known traditional antidiabetic herb used in China. In this study, dual high-resolution α-glucosidase and protein-tyrosine phosphatase 1B (PTP1B) inhibition profiling was used for the identification of individual antidiabetic constituents directly from the crude ethyl acetate extract and fractions of P...
May 24, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28490110/multivariate-statistical-analysis-of-the-polyphenolic-constituents-in-kiwifruit-juices-to-trace-fruit-varieties-and-geographical-origins
#13
Jing Guo, Yahong Yuan, Pei Dou, Tianli Yue
Fifty-one kiwifruit juice samples of seven kiwifruit varieties from five regions in China were analyzed to determine their polyphenols contents and to trace fruit varieties and geographical origins by multivariate statistical analysis. Twenty-one polyphenols belonging to four compound classes were determined by ultra-high-performance liquid chromatography coupled with ultra-high-resolution TOF mass spectrometry. (-)-Epicatechin, (+)-catechin, procyanidin B1 and caffeic acid derivatives were the predominant phenolic compounds in the juices...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28486427/an-efficient-method-for-the-preparative-isolation-and-purification-of-flavonoids-from-leaves-of-crataegus-pinnatifida-by-hsccc-and-pre-hplc
#14
Lei Wen, Yunliang Lin, Ruimin Lv, Huijiao Yan, Jinqian Yu, Hengqiang Zhao, Xiao Wang, Daijie Wang
In this work, flavonoid fraction from the leaves of Crataegus pinnatifida was separated into its seven main constituents using a combination of HSCCC coupled with pre-HPLC. In the first step, the total flavonoid extract was subjected to HSCCC with a two-solvent system of chloroform/methanol/water/n-butanol (4:3:2:1.5, v/v), yielding four pure compounds, namely (-)-epicatechin (1), quercetin-3-O-(2,6-di-α-l-rhamnopyranosyl)-β-d-galactopyranoside (2), 4''-O-glucosylvitexin (3) and 2''-O-rhamnosylvitexin (4) as well as a mixture of three further flavonoids...
May 9, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28481237/anti-onchocerca-and-anti-caenorhabditis-activity-of-a-hydro-alcoholic-extract-from-the-fruits-of-acacia-nilotica-and-some-proanthocyanidin-derivatives
#15
Jacqueline Dikti Vildina, Justin Kalmobe, Boursou Djafsia, Thomas J Schmidt, Eva Liebau, Dieudonne Ndjonka
Acacia nilotica fruits with high tannin content are used in the northern parts of Cameroon as anti-filarial remedies by traditional healers. In this study, the hydro-alcoholic fruit extract (crude extract (CE)) and, one of the main constituents in its most active fractions, (+)-catechin-3-O-gallate (CG), as well as four related proanthocyanidins, (-)-epicatechin-3-O-gallate (ECG), (+)-gallocatechin (GC), (-)-epigallocatechin (EGC) and (-)-epigallocatechin-3-O-gallate (EGCG), were assessed for their potential in vitro anthelmintic properties against the free-living model organism Caenorhabditis elegans and against the cattle filarial parasite Onchocerca ochengi...
May 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28480420/effects-of-different-hydroponic-substrate-combinations-and-watering-regimes-on-physiological-and-anti-fungal-properties-of-siphonochilus-aethiopicus
#16
Xego S, Kambizi L, Nchu F
BACKGROUND: Production of medicinal plants in controlled environments, particularly hydroponic technology, provides opportunities for high quality biomass accumulation and optimizes production of secondary metabolites. Applying special watering regimes in combination with efficient soil draining is an encouraging new tool for the production of pharmaceutical relevant plants. The purpose of this paper was to evaluate the effect of substrate combinations and watering regimes on nutrient uptake, anti-F...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28479727/exploratory-studies-of-epicatechin-a-bioactive-compound-of-phyllanthus-niruri-on-the-antioxidant-enzymes-and-oxidative-stress-markers-in-d-galactosamine-induced-hepatitis-in-rats-a-study-with-reference-to-clinical-prospective
#17
Bhasha Shanmugam, Kondeti Ramudu Shanmugam, Sahukari Ravi, Ganjikunta Venkata Subbaiah, Chilakala Ramakrishana, Korivi Mallikarjuna, Kesireddy Sathyavelu Reddy
BACKGROUND: Hepatitis is a health problem affecting millions of people worldwide and it is the major risk factor for liver cirrhosis. In India, many plants are used to treat hepatitis. But little is known about the effects of (-)-epicatechin a bioactive compound of Phyllanthus niruri (PN) in hepatitis rats. OBJECTIVE: The present study was designed to explore the antioxidant property of (-)-epicatechin isolated from PN in D-Galactosamine (D-GalN) induced hepatitis rats...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28471493/effects-of-vinification-techniques-combined-with-uv-c-irradiation-on-phenolic-contents-of-red-wines
#18
Hande Tahmaz, Gökhan Söylemezoğlu
Red wines are typically high in phenolic and antioxidant capacity and both of which can be increased by vinification techniques. This study employed 3 vinification techniques to assess the increase in phenolic compounds and antioxidant capacity. Wines were obtained from Boğazkere grape cultivar by techniques of classical maceration, cold maceration combined with ultraviolet light (UV) irradiation, and thermovinification combined with UV irradiation and changes in phenolic contents were examined. Total phenolic and anthocyanin contents and trolox equivalent antioxidant capacity of wines were measured spectrophotometrically and phenolic contents (+)-catechin, (-)-epicatechin, rutin, quercetin, trans-resveratrol, and cis-resveratrol were measured by High Pressure Liquid Chromatography with Diode Array Detection (HPLC-DAD)...
May 4, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28471298/optimized-ultra-high-pressure-assisted-extraction-of-procyanidins-from-lychee-pericarp-improves-the-antioxidant-activity-of-extracts
#19
Ruifen Zhang, Dongxiao Su, Fangli Hou, Lei Liu, Fei Huang, Lihong Dong, Yuanyuan Deng, Yan Zhang, Zhencheng Wei, Mingwei Zhang
To establish optimal ultra-high-pressure (UHP)-assisted extraction conditions for procyanidins from lychee pericarp, a response surface analysis method with four factors and three levels was adopted. The optimum conditions were as follows: 295 MPa pressure, 13 min pressure holding time, 16.0 mL/g liquid-to-solid ratio, and 70% ethanol concentration. Compared with conventional ethanol extraction and ultrasonic-assisted extraction methods, the yields of the total procyanidins, flavonoids, and phenolics extracted using the UHP process were significantly increased; consequently, the oxygen radical absorbance capacity and cellular antioxidant activity of UHP-assisted lychee pericarp extracts were substantially enhanced...
May 4, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28470323/differential-%C3%AE-amylase-%C3%AE-glucosidase-inhibitory-activities-of-plant-derived-phenolic-compounds-a-virtual-screening-perspective-for-the-treatment-of-obesity-and-diabetes
#20
Hassan Rasouli, Seyed Mohammad-Bagher Hosseini-Ghazvini, Hadi Adibi, Reza Khodarahmi
Recently, due to their biological properties, polyphenol-rich functional foods have been proposed to be unique supplementary and nutraceutical treatments for diabetes mellitus. Inhibition of α-amylase and α-glucosidase enzymes using natural products (especially polyphenols) is a novel oral policy to regulate carbohydrate metabolism and hyperglycemia. The present study aims to evaluate the α-amylase and α-glucosidase inhibitory activity of 26 polyphenols using molecular docking and virtual screening studies...
May 24, 2017: Food & Function
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