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Epicatechin

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https://www.readbyqxmd.com/read/29775211/proanthocyanidins-will-they-effectively-restrain-conspicuous-bacterial-strains-devolving-on-urinary-tract-infection
#1
REVIEW
Venkataseshan Jagannathan, Pragasam Viswanathan
Struvite or infection stones are one of the major clinical burdens among urinary tract infection, which occur due to the interaction between microbes and urine mineral components. Numerous urinary tract infection (UTI) causing microbes regulate through biofilm formation for survival from host defense, it is often found difficult in its eradication with simple anti-microbial agents and also the chance of recurrence and resistance development is significantly high. Cranberry consumption and maintenance of urinary tract health have been supported by clinical, epidemiological, and mechanistic studies...
May 18, 2018: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/29759183/evaluation-of-thrombin-inhibitory-activity-of-catechins-by-online-capillary-electrophoresis-based-immobilized-enzyme-microreactor-and-molecular-docking
#2
Qiao-Qiao Li, Feng-Qing Yang, Yin-Zhen Wang, Zhao-Yu Wu, Zhi-Ning Xia, Hua Chen
An online capillary electrophoresis (CE)-based thrombin (THR) immobilized enzyme microreactor (IMER) method was established to screen THR inhibitors in this study. S-2366 was used as chromogenic substrate for determination of THR activity and other kinetic constants. After continuously run for 50 times, the prepared IMER could still remain 89% of the initial immobilized enzyme activity. The Michaelis-Menten constant (Km ) of immobilized THR was measured as 0.514 mmol/L and the half-maximal inhibitory concentration (IC50 ) and inhibition constant (Ki ) of argatroban on THR were determined as 78...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29751901/subcritical-water-extraction-of-polyphenolic-compounds-from-sorghum-sorghum-bicolor-l-bran-and-their-biological-activities
#3
Xiaoping Luo, Jiemei Cui, Haihui Zhang, Yuqing Duan
Subcritical water extraction (SWE), an environment-friendly technique, was applied to extract polyphenolics from sorghum bran. Extraction temperatures (°C), time (min), and solid-liquid ratio (mL/g) were investigated and optimized by Box-Behnken design. The optimized conditions for SWE was 144.5 °C of temperature, 21 min of time, and 35 mL/g of solid-liquid ratio, with a polyphenolics yield of 47.253 ± 0.375 mg GAE/g dw, which was in good agree with the predicted value. Comparing with hot water extraction (HWE), SWE resulted in a higher yield of polyphenolics, higher radical scavenging activities, and more efficient antiproliferative activity...
October 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29751487/preparation-and-antioxidant-activity-of-ethyl-linked-anthocyanin-flavanol-pigments-from-model-wine-solutions
#4
Lingxi Li, Minna Zhang, Shuting Zhang, Yan Cui, Baoshan Sun
Anthocyanin-flavanol pigments, formed during red wine fermentation and storage by condensation reactions between anthocyanins and flavanols (monomers, oligomers, and polymers), are one of the major groups of polyphenols in aged red wine. However, knowledge of their biological activities is lacking. This is probably due to the structural diversity and complexity of these molecules, which makes the large-scale separation and isolation of the individual compounds very difficult, thus restricting their further study...
May 3, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29748816/epicatechin-s-cardiovascular-protective-effects-are-mediated-via-opioid-receptors-and-nitric-oxide
#5
Kirsty MacRae, Kylie Connolly, Rebecca Vella, Andrew Fenning
PURPOSE: Cardiovascular disease is the leading cause of mortality globally. Epicatechin has previously been shown to improve vascular responses and possess cardioprotective properties. However, the mechanisms underpinning these cardiotropic outcomes remain unknown. The aim of this study was to further identify epicatechin's mechanism of action in the cardiovasculature. METHODS: The effects of epicatechin on isolated rat conduit arteries, resistance vessels and cardiac electrophysiology were investigated on resting tension and precontracted vessels and cardiac action potential parameters, both in the presence and in the absence of various antagonists...
May 10, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29746001/evaluation-of-antioxidant-properties-phenolic-compounds-anthelmintic-and-cytotoxic-activities-of-various-extracts-isolated-from-nepeta-cadmea-an-endemic-plant-for-turkey
#6
Arzu Kaska, Nahide Deniz, Mehmet Çiçek, Ramazan Mammadov
Nepeta cadmea Boiss. is a species endemic to Turkey that belongs to the Nepeta genus. Several species of this genus are used in folk medicine. This study was designed to investigate the phenolic compounds, antioxidant, anthelmintic, and cytotoxic activities of various extracts (ethanol, methanol, acetone, and water) of N. cadmea. The antioxidant activities of these extracts were analyzed using scavenging methods (DPPH, ABTS, and H2 O2 scavenging activity), the β-carotene/linoleic acid test system, the phosphomolybdenum method, and metal chelating activity...
May 10, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29744906/on-line-high-performance-liquid-chromatography-coupled-with-biochemical-detection-method-for-screening-of-%C3%AE-glucosidase-inhibitors-in-green-tea
#7
Peng-Cheng Guo, Hua-Dan Shen, Jiang-Ji Fang, Tian-Ming Ding, Xiao-Ping Ding, Jun-Feng Liu
An on-line high performance liquid chromatography- biochemical detection (HPLC-BCD) method, which compounds separated by HPLC were on-line reacted with enzyme and substrate solutions delivered by flow injection and enzyme inhibition signal was collected in time by UV detector, was developed to rapidly screen α-glucosidase inhibitors from green tea extracts in this study. The chromatographic fingerprints and enzyme inhibition profiles of the different brands of green tea could be simultaneously detected by the on-line HPLC-BCD method...
May 9, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29744232/investigation-of-interactions-between-thrombin-and-ten-phenolic-compounds-by-affinity-capillary-electrophoresis-and-molecular-docking
#8
Qiao-Qiao Li, Yu-Xiu Yang, Jing-Wen Qv, Guang Hu, Yuan-Jia Hu, Zhi-Ning Xia, Feng-Qing Yang
Thrombin plays a vital role in blood coagulation, which is a key process involved in thrombosis by promoting platelet aggregation and converting fibrinogen to form the fibrin clot. In the receptor concept, drugs produce their therapeutic effects via interactions with the targets. Therefore, investigation of interaction between thrombin and small molecules is important to find out the potential thrombin inhibitor. In this study, affinity capillary electrophoresis (ACE) and in silico molecular docking methods were developed to study the interaction between thrombin and ten phenolic compounds ( p -hydroxybenzoic acid, protocatechuic acid, vanillic acid, gallic acid, catechin, epicatechin, dihydroquercetin, naringenin, apigenin, and baicalein)...
2018: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/29742305/red-grape-vitis-vinifera-l-flavonoids-down-regulate-collagen-type-iii-expression-after-uv-a-in-primary-human-dermal-blood-endothelial-cells
#9
Serena Di Francesco, Monica Savio, Nora Bloise, Giovanni Borroni, Lucia Anna Stivala, Riccardo G Borroni
Red grape (Vitis vinifera L.) flavonoids including flavan-3-ols (e.g., catechin and epicatechin), flavonols (e.g., quercetin) and anthocyanins (e.g., malvidin) exert anti-inflammatory and antioxidant activities. In the skin they also have a photoprotective action, and their effects have been extensively investigated in keratinocytes, melanocytes and fibroblasts. Despite their known effects also on blood vasculature, little is known on their activities on human dermal blood endothelial cells (HDBECs), which are critically involved in skin homeostasis as well as in the pathogenesis of neoplastic and inflammatory skin diseases...
May 9, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29740891/effects-of-gut-microbiota-and-time-of-treatment-on-tissue-levels-of-green-tea-polyphenols-in-mice
#10
Anna B Liu, Siyao Tao, Mao-Jung Lee, Qi Hu, Xiaofeng Meng, Yong Lin, Chung S Yang
The previous studies have shown that tea polyphenols are metabolized by gut microbiota. This study investigated the effect of gut microbiota on the bioavailability, tissue levels, and degradation of tea polyphenols. Mice were treated with antibiotics (ampicillin/sulfamethoxazole/trimethoprim) in drinking water and the control mice received water for 11 days, and they were given an AIN93M diet enriched with 0.32% of Polyphenon E. The levels of catechins and their metabolites (if present) in the serum, liver, urine, and fecal samples were determined by high-performance liquid chromatography...
May 8, 2018: BioFactors
https://www.readbyqxmd.com/read/29739608/phenolic-compounds-as-beneficial-phytochemicals-in-pomegranate-punica-granatum-l-peel-a-review
#11
Balwinder Singh, Jatinder Pal Singh, Amritpal Kaur, Narpinder Singh
Pomegranate peel (PoP), a juice byproduct often considered as a waste, comprises nearly around 30-40% portion of the fruit. Phenolic compounds (one class of bioactive phytochemicals) are primarily concentrated in the peel portion of pomegranate fruit. In PoP, the main phenolic compounds reported in the literature include flavonoids (anthocyanins such as pelargonidin, delphinidin, cyanidin along with their derivatives and anthoxanthins such as catechin, epicatechin and quercetin), tannins (ellagitannins and ellagic acid derivatives such as punicalagin, punicalin and pedunculagin) and phenolic acids (such as chlorogenic, caffeic, syringic, sinapic, p-coumaric, ferulic, ellagic, gallic and cinnamic acid)...
September 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29739583/the-impact-of-high-pressure-processing-on-the-phenolic-profile-hydrophilic-antioxidant-and-reducing-capacity-of-pur%C3%A3-e-obtained-from-commercial-tomato-varieties
#12
Maja Jeż, Wiesław Wiczkowski, Danuta Zielińska, Ireneusz Białobrzewski, Wioletta Błaszczak
The effect of high hydrostatic pressure (HHP) (450-550-650 MPa/5-10-15 min) on polyphenols profile of purée obtained from commercial tomato varieties (Maliniak, Cerise, Black Prince and Lima) was investigated. Individual polyphenols, total phenolic index (TPI) were quantified using a mass spectrometer (HPLC-MS/MS). Photochemiluminescence (PCLACW), cyclic voltammetry (CV) and ferric reducing antioxidant power (FRAP) assays were used to determine the antioxidant capacity of the hydrophilic extract. The results demonstrated that at certain processing conditions, HHP may enhance or decrease the nutritional quality of tomato purée...
September 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29735097/uhplc-qqq-ms-ms-identification-quantification-of-polyphenols-from-passiflora-subpeltata-fruit-pulp-and-determination-of-nutritional-antioxidant-%C3%AE-amylase-and-%C3%AE-glucosidase-key-enzymes-inhibition-properties
#13
Saravanan Shanmugam, Isla Alcântara Gomes, Marina Denadai, Bruno Dos Santos Lima, Adriano Antunes de Souza Araújo, Narendra Narain, Maria Terezinha Santos Leite Neta, Mairim Russo Serafini, Lucindo José Quintans-Júnior, Parimelazhagan Thangaraj
The diabetic key enzymes inhibition, nutritional, antioxidant activity and bioactive compounds identification of Passiflora subpeltata fruit pulp were investigated. Fifteen polyphenolic compounds including protocatechuic acid, ferulic acid, vanillic acid, epicatechin, p-coumaric acid, cinnamic acid, eriodictyol and quercetin-3-glucoside were identified in the pulp of this species by using UHPLC-QqQ-MS/MS analysis. The total carbohydrates and crude protein contents in fruit pulp were 2.62 mg glucose equivalent/g sample fruit pulp and 8...
June 2018: Food Research International
https://www.readbyqxmd.com/read/29732583/analgesic-and-anti-inflammatory-activities-of-epicatechin-gallate-from-bauhinia-hookeri
#14
Eman Al-Sayed, Mohamed M Abdel-Daim
Hit, Lead & Candidate Discovery The acetic acid-induced writhing and hot plate models in mice were utilized to determine the analgesic effect of epicatechin gallate (ECG) isolated from Bauhinia hookeri. The anti-inflammatory activity of ECG was determined using carrageenan-induced paw edema model. The pro-inflammatory mediators (PGE2 , TNF-α, IL-1β, and IL-6) were estimated in the plasma of different treatment groups. ECG was tested at doses of 100, 200, and 400 mg/kg p.o. and diclofenac sodium was used as a standard drug (100 mg/kg) in all experiments...
May 6, 2018: Drug Development Research
https://www.readbyqxmd.com/read/29724043/green-extraction-of-natural-antioxidants-from-the-sterculia-nobilis-fruit-waste-and-analysis-of-phenolic-profile
#15
Jiao-Jiao Zhang, Ya Li, Sheng-Jun Lin, Hua-Bin Li
The waste of Sterculia nobilis fruit was massively produced during food processing, which contains lots of natural antioxidants. In this study, antioxidants in the Sterculia nobilis fruit waste were extracted using the green microwave-assisted extraction (MAE) technique. The effects of five independent variables (ethanol concentration, solvent/material ratio, extraction time, temperature, and microwave power) on extraction efficiency were explored, and three major factors (ethanol concentration, extraction time, and temperature) showing great influences were chosen to study their interactions by response surface methodology...
May 2, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29722013/effect-of-shading-intensity-on-morphological-and-color-traits-and-chemical-components-of-new-tea-camellia-sinensis-l-shoots-under-direct-covering-cultivation
#16
Tomohito Sano, Hideki Horie, Akiko Matsunaga, Yuhei Hirono
BACKGROUND: Use of covering cultivation to shade tea (Camellia sinensis L.) trees to produce high-quality, high-priced green tea has recently increased in Japan. Knowledge of shading effects on morphological and color traits, and chemical components of new tea shoots is important for product quality and productivity. We assessed these traits of tea shoots and their relationships under covering cultivation of various radiation intensities. RESULTS: Leaf thickness, LMA (leaf mass per area), and leaf density of new tea leaves were smaller under covering culture than under open-field culture...
May 2, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29716863/analysis-of-the-main-constituents-of-changshu-tablet-and-its-spasmolysis-effect-against-contraction-induced-by-acetylcholine-in-the-rat-isolated-intestinal-smooth-muscle
#17
Ying An, Guangming Song, Dailin Liu, Tianyi Mao, Yanmin Zhao, Wenli Xie
The Changshu tablet (CST), one kind of Chinese patent medicine with astringent to the intestine and relieving diarrhea, was made by the root of Rose odorata Sweet var. gigantean (Coll.et Hemsl.) Rehd.et Wils. Although CST has a long history of clinical application, but the research of its chemical composition is less. So the objective of this study was to investigate the main constituents and preliminarily research its effect of the contraction of isolated intestine in vitro. The contents of total polyphenols (126...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29698774/biofilm-inhibition-mechanism-from-extract-of-hymenocallis-littoralis-leaves
#18
Naiem H Nadaf, Rishikesh S Parulekar, Rahul S Patil, Trupti K Gade, Anjum A Momin, Shailesh R Waghmare, Maruti J Dhanavade, Akalpita U Arvindekar, Kailas D Sonawane
ETHNOPHARMACOLOGICAL RELEVANCE: Hymenocallis littoralis (Jacq.) Salisb. has been referred as beach spider lily and commonly known for its rich phytochemical diversity. Phytochemicals such as alkaloids, volatile constituents, phenols, flavonoids, flavonols extracted from different parts of these plants like bulbs, flowers, leaf, stem and root had been used in folk medicines from ancient times because of their excellent antimicrobial and antioxidant properties. The leaf and bulb extract of H...
April 23, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29694801/combining-factors-that-individually-enhance-memory-in-lymnaea
#19
Ryan Tan, Ken Lukowiak
When applied individually, thermal stress (1 hour at 30 °C) and (-)epicatechin (a flavonol found in green tea, e.g.) each enhance long-term memory formation following operant conditioning of Lymnaea aerial respiratory behavior. Snails demonstrate enhanced long-term memory formation when trained in epicatechin-treated pond water or when placed in 30 °C pond water for 1 hour, 1 hour prior to training in pond water. We ask here whether the combined application of epicatechin + thermal stress enhances long-term memory retention length beyond the maximal lengths of the individual factors alone...
February 2018: Biological Bulletin
https://www.readbyqxmd.com/read/29690635/quantitative-analysis-of-four-catechins-from-green-tea-extract-in-human-plasma-using-ultra-performance-liquid-chromatography-tandem-mass-spectrometry-for-pharmacokinetic-studies
#20
Jeong-Eun Park, Tae-Eun Kim, Kwang-Hee Shin
Green tea is consumed as a beverage worldwide and has beneficial effects, such as a lower risk of cardiovascular disease and cancer. A quantitative analysis of the beneficial components in plasma is important for understanding the potential health benefits of green tea. Four catechins—epigallocatechin-3-gallate (EGCG), epicatechin-3-gallate (ECG), epigallocatechin (EGC), and epicatechin (EC)—which account for the majority of the components of green tea, were analyzed by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)...
April 23, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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