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Lactate AND DHEA

Wen-Chyuan Chen, Yi-Ming Chen, Chi-Chang Huang, Yen-Dun Tzeng
Dehydroepiandrosterone (DHEA), the most abundant sex steroid, is primarily secreted by the adrenal gland and a precursor hormone used by athletes for performance enhancement. Whole-body vibration (WBV) is a well-known light-resistance exercise by automatic adaptations to rapid and repeated oscillations from a vibrating platform, which is also a simple and convenient exercise for older adults. However, the potential effects of DHEA supplementation combined with WBV training on to body composition, exercise performance, and hormone regulation are currently unclear...
2016: International Journal of Medical Sciences
Hong-Li Xie, Yan-Bo Wang, Guang-Zhong Jiao, De-Ling Kong, Qing Li, Hong Li, Liang-Liang Zheng, Jing-He Tan
Although there are many reports on the effect of glucose metabolism on oocyte nuclear maturation, there are few studies on its effect on ooplasmic maturation. By manipulating glucose metabolism pathways using a maturation medium that could support oocyte nuclear maturation but only a limited blastocyst formation without glucose, this study determined effects of glucose metabolism pathways on ooplasmic maturation. During maturation of cumulus-oocyte-complexes (COCs) with glucose, the presence of PPP inhibitor, DHEA or glycolysis inhibitor, iodoacetate significantly decreased blastocyst rates, intraoocyte glutathione and ATP...
2016: Scientific Reports
Tânia R Dias, Marco G Alves, Susana P Almeida, Joaquina Silva, Alberto Barros, Mário Sousa, Branca M Silva, Samuel M Silvestre, Pedro F Oliveira
Dehydroepiandrosterone (DHEA) is a precursor of androgen synthesis whose action is partially exerted through its metabolites. 7-Oxo-dehydroepiandrosterone (7-oxo-DHEA) is a common DHEA metabolite, non-convertible to androgens, which constitutes a promising therapeutic strategy for multiple conditions. Sertoli cells (SCs) are responsible for the support of spermatogenesis, having unique metabolic characteristics strongly modulated by androgens. Consequently, disruptions in androgen synthesis compromise SCs function and hence male fertility...
November 2015: Journal of Steroid Biochemistry and Molecular Biology
Kannamannadiar Jayaprakasan, Amarin Narkwichean, Walid E Maalouf, Bruce K Campbell
INTRODUCTION: Dehydroepiandrosterone (DHEA) has been proposed to improve pregnancy rates in women with diminished ovarian reserve undergoing in vitro fertilisation (IVF) treatment. However, evidence regarding its efficacy is supported by a limited number of randomised controlled trials (RCTs). This double-blinded RCT aims to measure the effect of DHEA supplementation prior to and during controlled ovarian hyperstimulation on ovarian response prior to IVF treatment in women predicted to have poor ovarian reserve...
2014: BMJ Open
Bijay Prakash Tripathi, Nidhi Chandrama Dubey, Manfred Stamm
Thermoresponsive core-shell microgels with degradable core are synthesized via surfactant based free radical polymerization using N,N'-(1,2-dihydroxy-ethylene)bis(acrylamide) (DHEA) as a cross-linker for core preparation. The 1,2-glycol bond present in DHEA is susceptible to NaIO4 solution, and thus, the structure can be cleaved off resulting in hollow microgel. Ultrathin membranes are prepared by suction filtration of a dilute suspension of core-shell microgels over a sacrificial layer of Cd(OH)2 nanostrand coated on track etched membrane...
October 22, 2014: ACS Applied Materials & Interfaces
Rafaela S C Takeshita, Fred B Bercovitch, Michael A Huffman, Keiko Mouri, Cécile Garcia, Lucie Rigaill, Keiko Shimizu
The ability to determine hormonal profiles of primate populations using non-invasive techniques can help to monitor physical fitness, stress, and physiological responses to environmental changes. We investigated fecal glucocorticoids (fGC) and DHEAS concentrations in captive Japanese macaques (Macaca fuscata) in relation to environmental, biological, and social factors. The subjects were female Japanese monkeys from 4 months to 31 years old housed in captivity (27 in social groups and 12 in single cages). Fecal samples were collected from all females, and behavioral data from the social groups during the mating season and the following birth season...
November 2014: American Journal of Primatology
Houssem Zorgati, Fabrice Prieur, Thomas Vergniaud, François Cottin, Manh-Cuong Do, Zakaria Labsy, David Amarantini, Olivier Gagey, Françoise Lasne, Katia Collomp
All systemically administered glucocorticoids (GC) are prohibited in-competition, because of the potential ergogenic effects. Although short-term GC intake has been shown to improve performance during submaximal exercise, literature on its impact during brief intense exercise appears to be very scant. The purpose of this study was to examine the ergogenic and metabolic effects of prednisone during repeated bouts of high-intensity exercise. In a double-blind randomized protocol, ten recreational male athletes followed two 1-week treatments (Cor: prednisone, 60mg/day or Pla: placebo)...
August 2014: Steroids
P Sgrò, F Romanelli, F Felici, M Sansone, S Bianchini, C F Buzzachera, C Baldari, L Guidetti, F Pigozzi, A Lenzi, L Di Luigi
BACKGROUND: Few and conflicting data on the acute adaptive role of the hypothalamic-pituitary-testicular (HPT) axis to sub-maximal endurance exercise exist. AIMS: To investigate the acute HPT axis responses to standardized endurance exercises in a laboratory setting and the correlations between testosterone and classic adaptive hormones variations. SUBJECTS AND METHODS: 12 healthy male volunteers were recruited for this experimental study...
January 2014: Journal of Endocrinological Investigation
D Grasso, R Corsetti, P Lanteri, C Di Bernardo, A Colombini, R Graziani, G Banfi, G Lombardi
Muscle traction and bone metabolism are functionally linked and co-regulated by a series of factors. Although a role for steroid hormones was hypothesized, a clear definition of the bone-muscle interconnection still lacks. To investigate this relationship, we studied bone metabolism, muscle activity, and salivary steroid hormones profile in relation with the physical effort across a cycling stage race, a model of effort in absence of load. Nine pro-cyclists were recruited; body weight and power output/energy expenditure were recorded...
February 2015: Scandinavian Journal of Medicine & Science in Sports
P Regal, A Cepeda, C Fente
Hormones work in harmony in the body, and this status must be maintained to avoid metabolic disequilibrium and the subsequent illness. Besides, it has been reported that exogenous steroids (presence in the environment and food products) influence the development of several important illnesses in humans. Endogenous steroid hormones in food of animal origin are unavoidable as they occur naturally in these products. The presence of hormones in food has been connected with several human health problems. Bovine milk contains considerable quantities of hormones and it is of particular concern...
2012: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Luigi Di Luigi, Paolo Sgrò, Carlo Baldari, Maria Chiara Gallotta, Gian Pietro Emerenziani, Clara Crescioli, Serena Bianchini, Francesco Romanelli, Andrea Lenzi, Laura Guidetti
Phosphodiesterase type 5 inhibitors may influence human physiology, health, and performance by also modulating endocrine pathways. We evaluated the effects of a 2-day tadalafil administration on adenohypophyseal and adrenal hormone adaptation to exercise in humans. Fourteen healthy males were included in a double-blind crossover trial. Each volunteer randomly received two tablets of placebo or tadalafil (20 mg/day with a 36-h interval) before a maximal exercise was performed. After a 2-wk washout, the volunteers were crossed over...
April 15, 2012: American Journal of Physiology. Endocrinology and Metabolism
Hongyan Zhou, Kazuhiro Kimura, Tomoko Orita, Teruo Nishida, Koh-Hei Sonoda
PURPOSE: Corneal fibroblasts contribute to collagen remodeling in the corneal stroma in part by mediating collagen degradation. Given that corneal structure is influenced by sex hormone status, we examined the effects of sex hormones on collagen degradation by corneal fibroblasts. METHODS: Rabbit corneal fibroblasts were cultured in three-dimensional collagen gels with or without sex hormones including 17β-estradiol, progesterone, testosterone, and dehydroepiandrosterone (DHEA)...
2011: Molecular Vision
Danielle Kaiser de Souza, Maria Flávia Marques Ribeiro, Luiz Carlos Rios Kucharski
Dehydroepiandrosterone (DHEA) prevents brain aging, enhances the cerebral metabolism and interacts with energy substrates. The interaction between lactate and DHEA on glucose uptake and lactate oxidation by various nervous structures was investigated and results demonstrate that the 2-(14)C-deoxiglucose (2-(14)C-Dglucose) uptake was stimulated by 10mM lactate in the hypothalamus and olfactory bulb, inhibited in the cerebral cortex and cerebellum, and unaffected in the hippocampus. We also show that, in both the cerebral cortex and hypothalamus, (14)C-lactate oxidation was higher than (14)C-glucose oxidation (p≤0...
January 17, 2012: Neuroscience Letters
Ikhlass Tabidi, David Saggerson
Incubation of adult rat cardiac myocytes with increasing glucose concentrations decreased phosphorylation (αThr172) and activity of AMPK (AMP-activated protein kinase). The effect could be demonstrated without measurable changes in adenine nucleotide contents. The glucose effect was additive to the decrease in AMPK activity caused by insulin, was attenuated by adrenaline, was not mimicked by glucose analogues, lactate or pyruvate and was not due to changes in myocyte glycogen content. AMPK activity was decreased by xylitol and PMS (phenazine methosulfate) and was increased by the glucose-6-phosphate dehydrogenase inhibitor DHEA (dehydroepiandrosterone) and by thiamine...
June 2012: Bioscience Reports
Benjamin Campbell
OBJECTIVES: To addresses the hypothesis that human adrenarche is associated with extended juvenile brain development by comparing the timing of adrenal androgen production, brain development and lactation in a larger comparative mammalian context. METHODS: Findings from published literature are used to compare the developmental timing of adrenal androgens, brain glucose utilization and lactation in rats, rhesus macaques and humans. RESULTS: Comparison of the timing of androstenedione and progesterone production with developmental patterns of cortical glucose utilization and the timing of lactation in laboratory rats suggest that the rise and fall of adrenal hormone production centered on weaning plays a role in synaptogenesis during lactation as well as post weaning synaptic pruning...
January 2011: American Journal of Human Biology: the Official Journal of the Human Biology Council
Bénédicte Le Panse, Rémi Thomasson, Laetitia Jollin, Anne-Marie Lecoq, Virgile Amiot, Nathalie Rieth, Jacques De Ceaurriz, Katia Collomp
The present study investigated whether short-term oral administration of glucocorticoid would modify performance and selected hormonal and metabolic parameters during submaximal exercise in healthy women. Nine recreational female athletes completed cycling trials at 70-75% VO(2) max until exhaustion after either placebo (Pla, gelatin) or oral prednisone (Cor, Cortancyl, 50 mg per day for 1 week) treatment, according to a double-blind and randomized protocol. Blood samples were collected at rest; after 10, 20, and 30 min of exercise; at exhaustion; and after 10 and 20 min of passive recovery for adrenocorticotrophic hormone (ACTH), dehydroepiandrosterone (DHEA), prolactin (PRL), growth hormone (GH), insulin (Ins), blood glucose (Glu), and lactate (Lac) determination...
November 2009: European Journal of Applied Physiology
Maqsood M Elahi, Felino R Cagampang, Dhea Mukhtar, Frederick W Anthony, Sunil K Ohri, Mark A Hanson
In rodents, adverse prenatal nutrition, such as a maternal diet rich in fat during pregnancy, enhances susceptibility of the offspring to hypertension, type 2 diabetes and other features of the human metabolic syndrome in adulthood. However, previous experimental studies were confined to short-term modifications of the maternal diet during pregnancy and/or lactation periods, a situation uncommon in humans. Moreover in humans, the offspring may also consume a high-fat diet, which may take them beyond the range to which their development has adapted them to respond healthily...
August 2009: British Journal of Nutrition
Monika Leśkiewicz, Magdalena Regulska, Bogusława Budziszewska, Danuta Jantas, Lucylla Jaworska-Feil, Agnieszka Basta-Kaim, Marta Kubera, Władysław Lasoń
Previously, we found that neurosteroids inhibited hydrogen peroxide- and staurosporine-induced damage of undifferentiated human neuroblastoma SH-SY5Y cells. However, differentiated neuroblastoma cells morphologically and functionally resemble neuronal cells, and are thus considered to be a model system for studying neuronal apoptotic processes. In the present study, we examined the effects of dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), and pregnenolone (PGL) on the viability of retinoic acid-differentiated human neuroblastoma SH-SY5Y cells...
September 2008: Pharmacological Reports: PR
Alessio Metere, Egidio Iorio, Donatella Pietraforte, Franca Podo, Maurizio Minetti
Peroxynitrite crosses the red blood cell (RBC) membrane and reacts with hemoglobin (Hb) producing mainly metHb, which is reduced back to ferrousHb by NADH- and NADPH-dependent reductases. Peroxynitrite also induces band 3 (B3) tyrosine phosphorylation, a signaling pathway believed to activate glucose metabolism. This study was aimed to decipher the relationship between these two peroxynitrite-dependent processes. Peroxynitrite induced a burst of the hexose monophosphate shunt (HMS), revealed by NMR studies, and a burst of the glycolytic pathway, measured by lactate production...
April 15, 2009: Archives of Biochemistry and Biophysics
M Leskiewicz, M Regulska, B Budziszewska, D Jantas, L Jaworska-Feil, A Basta-Kaim, M Kubera, G Jagla, W Nowak, W Lason
Neurosteroids are important regulators of central nervous system function and may be involved in processes of neuronal cell survival. This study was undertaken to test the effect of dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), pregnenolone (PGL), pregnenolone sulfate (PGLS), and allopregnanolone (Allo) on hydrogen peroxide- and staurosporine-induced toxicity in SH-SY5Y cells. It has been found that DHEAS inhibited the hydrogen peroxide toxicity in a concentration-dependent manner, whereas DHEA was active only at higher doses...
May 1, 2008: Journal of Neuroscience Research
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