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https://www.readbyqxmd.com/read/28241263/bridging-knowledge-gaps-to-understand-how-zika-virus-exposure-and-infection-affect-child-development
#1
Bill G Kapogiannis, Nahida Chakhtoura, Rohan Hazra, Catherine Y Spong
Importance: The Zika virus (ZIKV) epidemic has profoundly affected the lives of children and families across the Americas. As the number of children born with ZIKV-related complications continues to grow, the long-term developmental trajectory for these children and the effect on their families remains largely unknown. In September 2016, the Eunice Kennedy Shriver National Institute of Child Health and Human Development and partner National Institutes of Health institutes convened a workshop to develop a research agenda to improve the evaluation, monitoring, and management of neonates, infants, or children affected by ZIKV and its complications...
February 20, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28240958/comparison-of-the-diagnostic-performance-of-bacterial-culture-of-nasopharyngeal-swab-and-bronchoalveolar-lavage-fluid-samples-obtained-from-calves-with-bovine-respiratory-disease
#2
Sarah F Capik, Brad J White, Brian V Lubbers, Michael D Apley, Keith D DeDonder, Robert L Larson, Greg P Harhay, Carol G Chitko-McKown, Dayna M Harhay, Ted S Kalbfleisch, Gennie Schuller, Michael L Clawson
OBJECTIVE To compare predictive values, extent of agreement, and gamithromycin susceptibility between bacterial culture results of nasopharyngeal swab (NPS) and bronchoalveolar lavage fluid (BALF) samples obtained from calves with bovine respiratory disease (BRD). ANIMALS 28 beef calves with clinical BRD. PROCEDURES Pooled bilateral NPS samples and BALF samples were obtained for bacterial culture from calves immediately before and at various times during the 5 days after gamithromycin (6 mg/kg, SC, once) administration...
March 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28240728/%C3%AF-%C3%AF-occupational-medicine-in-italian-academy-what-future
#3
Pietro Apostoli
The entire Italian University system, including the whole field of medical teaching and research, is currently passing through a period of cumbersome changes due to the many difficulties encountered in its reform process. Academic occupational medicine is deeply involved in this process that resembles a real crisis. Given this background, this contribution - written as President of the Italian College of Occupational Medicine Full Professors - has the main objective to open a debate about the current generalized crisis of our Academic Discipline and about its possible future developments...
February 15, 2017: La Medicina del Lavoro
https://www.readbyqxmd.com/read/28240256/a-comparison-of-host-gene-expression-signatures-associated-with-infection-in-vitro-by-the-makona-and-ecran-mayinga-variants-of-ebola-virus
#4
Andrew Bosworth, Stuart D Dowall, Isabel Garcia-Dorival, Natasha Y Rickett, Christine B Bruce, David A Matthews, Yongxiang Fang, Waleed Aljabr, John Kenny, Charlotte Nelson, Thomas R Laws, E Diane Williamson, James P Stewart, Miles W Carroll, Roger Hewson, Julian A Hiscox
The Ebola virus (EBOV) variant Makona (which emerged in 2013) was the causative agent of the largest outbreak of Ebola Virus Disease recorded. Differences in virus-host interactions between viral variants have potential consequences for transmission, disease severity and mortality. A detailed profile of the cellular changes induced by the Makona variant compared with other Ebola virus variants was lacking. In this study, A549 cells, a human cell line with a robust innate response, were infected with the Makona variant or with the Ecran variant originating from the 1976 outbreak in Central Africa...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28239595/tuberculosis-of-olfactory-area-a-rare-presentation
#5
Deepak Dalmia, Jeena Pillai, Pankil Shah, Jasleen Kaur
Nasal tuberculosis is a rare clinical entity even in developing countries where tuberculosis of respiratory tract is extremely high. It becomes more difficult to diagnose if it presents with symptoms which are not commonly associated with nasal tuberculosis. Here we report the diagnosis, treatment and follow up of a rare case of primary nasal tuberculosis of olfactory groove region. Early diagnosis and timely treatment will certainly reduce the morbidity of this disease.
March 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28239450/erratum-to-scaling-up-strategies-of-the-chronic-respiratory-disease-programme-of-the-european-innovation-partnership-on-active-and-healthy-ageing-action-plan-b3-area-5
#6
J Bousquet, J Farrell, G Crooks, P Hellings, E H Bel, M Bewick, N H Chavannes, J Correia de Sousa, A A Cruz, T Haahtela, G Joos, N Khaltaev, J Malva, A Muraro, M Nogues, S Palkonen, S Pedersen, C Robalo-Cordeiro, B Samolinski, T Strandberg, A Valiulis, A Yorgancioglu, T Zuberbier, A Bedbrook, W Aberer, M Adachi, A Agusti, C A Akdis, M Akdis, J Ankri, A Alonso, I Annesi-Maesano, I J Ansotegui, J M Anto, S Arnavielhe, H Arshad, C Bai, I Baiardini, C Bachert, A K Baigenzhin, C Barbara, E D Bateman, B Beghé, A Ben Kheder, K S Bennoor, M Benson, K C Bergmann, T Bieber, C Bindslev-Jensen, L Bjermer, H Blain, F Blasi, A L Boner, M Bonini, S Bonini, S Bosnic-Anticevitch, L P Boulet, R Bourret, P J Bousquet, F Braido, A H Briggs, C E Brightling, J Brozek, R Buhl, P G Burney, A Bush, F Caballero-Fonseca, D Caimmi, M A Calderon, P M Calverley, P A M Camargos, G W Canonica, T Camuzat, K H Carlsen, W Carr, A Carriazo, T Casale, A M Cepeda Sarabia, L Chatzi, Y Z Chen, R Chiron, E Chkhartishvili, A G Chuchalin, K F Chung, G Ciprandi, I Cirule, L Cox, D J Costa, A Custovic, R Dahl, S E Dahlen, U Darsow, G De Carlo, F De Blay, T Dedeu, D Deleanu, E De Manuel Keenoy, P Demoly, J A Denburg, P Devillier, A Didier, A T Dinh-Xuan, R Djukanovic, D Dokic, H Douagui, G Dray, R Dubakiene, S R Durham, M S Dykewicz, Y El-Gamal, R Emuzyte, L M Fabbri, M Fletcher, A Fiocchi, A Fink Wagner, J Fonseca, W J Fokkens, F Forastiere, P Frith, M Gaga, A Gamkrelidze, J Garces, J Garcia-Aymerich, B Gemicioğlu, J E Gereda, S González Diaz, M Gotua, I Grisle, L Grouse, Z Gutter, M A Guzmán, L G Heaney, B Hellquist-Dahl, D Henderson, A Hendry, J Heinrich, D Heve, F Horak, J O' B Hourihane, P Howarth, M Humbert, M E Hyland, M Illario, J C Ivancevich, J R Jardim, E J Jares, C Jeandel, C Jenkins, S L Johnston, O Jonquet, K Julge, K S Jung, J Just, I Kaidashev, M R Khaitov, O Kalayci, A F Kalyoncu, T Keil, P K Keith, L Klimek, B Koffi N'Goran, V Kolek, G H Koppelman, M L Kowalski, I Kull, P Kuna, V Kvedariene, B Lambrecht, S Lau, D Larenas-Linnemann, D Laune, L T T Le, P Lieberman, B Lipworth, J Li, K Lodrup Carlsen, R Louis, W MacNee, Y Magard, A Magnan, B Mahboub, A Mair, I Majer, M J Makela, P Manning, S Mara, G D Marshall, M R Masjedi, P Matignon, M Maurer, S Mavale-Manuel, E Melén, E Melo-Gomes, E O Meltzer, A Menzies-Gow, H Merk, J P Michel, N Miculinic, F Mihaltan, B Milenkovic, G M Y Mohammad, M Molimard, I Momas, A Montilla-Santana, M Morais-Almeida, M Morgan, R Mösges, J Mullol, S Nafti, L Namazova-Baranova, R Naclerio, A Neou, H Neffen, K Nekam, B Niggemann, G Ninot, T D Nyembue, R E O'Hehir, K Ohta, Y Okamoto, K Okubo, S Ouedraogo, P Paggiaro, I Pali-Schöll, P Panzner, N Papadopoulos, A Papi, H S Park, G Passalacqua, I Pavord, R Pawankar, R Pengelly, O Pfaar, R Picard, B Pigearias, I Pin, D Plavec, D Poethig, W Pohl, T A Popov, F Portejoie, P Potter, D Postma, D Price, K F Rabe, F Raciborski, F Radier Pontal, S Repka-Ramirez, S Reitamo, S Rennard, F Rodenas, J Roberts, J Roca, L Rodriguez Mañas, C Rolland, M Roman Rodriguez, A Romano, J Rosado-Pinto, N Rosario, L Rosenwasser, M Rottem, D Ryan, M Sanchez-Borges, G K Scadding, H J Schunemann, E Serrano, P Schmid-Grendelmeier, H Schulz, A Sheikh, M Shields, N Siafakas, Y Sibille, T Similowski, F E R Simons, J C Sisul, I Skrindo, H A Smit, D Solé, T Sooronbaev, O Spranger, R Stelmach, P J Sterk, J Sunyer, C Thijs, T To, A Todo-Bom, M Triggiani, R Valenta, A L Valero, E Valia, E Valovirta, E Van Ganse, M van Hage, O Vandenplas, T Vasankari, B Vellas, J Vestbo, G Vezzani, P Vichyanond, G Viegi, C Vogelmeier, T Vontetsianos, M Wagenmann, B Wallaert, S Walker, D Y Wang, U Wahn, M Wickman, D M Williams, S Williams, J Wright, B P Yawn, P K Yiallouros, O M Yusuf, A Zaidi, H J Zar, M E Zernotti, L Zhang, N Zhong, M Zidarn, J Mercier
[This corrects the article DOI: 10.1186/s13601-016-0116-9.].
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28239383/effects-of-cigarette-smoking-on-transplant-survival-extending-or-shortening-it
#7
Feifei Qiu, Ping Fan, Golay D Nie, Huazhen Liu, Chun-Ling Liang, Wanlin Yu, Zhenhua Dai
Cigarette smoking (CS) regulates both innate and adaptive immunity and causes numerous diseases, including cardiovascular, respiratory, and autoimmune diseases, allergies, cancers, and transplant rejection. Therefore, smoking poses a serious challenge to the healthcare system worldwide. Epidemiological studies have always shown that CS is one of the major risk factors for transplant rejection, even though smoking plays redundant roles in regulating immune responses. The complex roles for smoking in immunoregulation are likely due to molecular and functional diversities of cigarette smoke components, including carbon monoxide (CO) and nicotine...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28239374/moraxella-catarrhalis-macrolide-resistant-isolates-are-highly-concentrated-in-two-mlst-clonal-complexes-ccn10-and-cc363
#8
Ya-Li Liu, Meng Xiao, Jing-Wei Cheng, He-Ping Xu, Zhi-Peng Xu, Sha Ye, Wen-Juan Zhang, Timothy Kudinha, Fanrong Kong, Ying-Chun Xu
To gain some insights into the molecular evolution of Moraxella catarrhalis macrolide resistance, PCR and sequencing analysis of the 23S rRNA gene, copB typing and multilocus sequence typing (MLST) were performed on 181 M. catarrhalis isolates. The isolates were obtained from children (n = 47) and adults (n = 134) presenting with respiratory disease in the years 2010-2014. Macrolide resistance was highly age-related, and nucleotide position alterations at A2330T could be detected in all macrolide-resistant isolates...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28239178/prevalence-and-characteristics-of-exercise-induced-bronchoconstriction-in-high-school-and-college-athletes-at-2-240-m-altitude
#9
Martín Becerril-Ángeles, Mario H Vargas, Leonardo Hernández-Pérez, Nancy Judith Rivera-Istepan, Rebeca Ivonne Pérez-Hidalgo, Ana Gabriela Ortega-González, Severino Rubio-Domínguez, María Cristina Rodríguez-Gutiérrez, Radamés Gaxiola-Cortés, Rodrigo Dosal-Ulloa, Laura Graciela Gochicoa-Rangel
BACKGROUND: Athletes practicing strenuous physical activities may develop exercise-induced bronchoconstriction (EIB). We aimed to determine the prevalence and features of this condition in Mexico City (altitude, 2,240 m). METHODS: In the present study, 208 high school and college athletes performed a standardized EIB test on a treadmill. RESULTS: Responses to exercise had large between-subject variability in all physiological parameters (forced expiratory volume in one second [FEV1], heart rate, blood oxygen saturation level [SpO2], blood pressure), with nearly similar proportions of subjects in whom FEV1 increased or decreased...
January 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28239040/efficacy-of-type-2-porcine-reproductive-and-respiratory-syndrome-virus-prrsv-vaccine-against-the-2010-isolate-of-vietnamese-highly-pathogenic-prrsv-challenge-in-pigs
#10
Hiroshi Iseki, Kenji Kawashima, Nguyen Tung, Kenjiro Inui, Mitsutaka Ikezawa, Tomoyuki Shibahara, Makoto Yamakawa
The efficacy of a commercial attenuated live type 2 porcine reproductive and respiratory syndrome (PRRS) vaccine was tested under experimental infection with a highly virulent Vietnamese virus isolated from a diseased pig affected with highly pathogenic PRRS (HP-PRRS) using specific pathogen-free (SPF) pigs. Twenty-five 4-week-old SPF pigs were divided into three groups as follows: pigs vaccinated with a single dose of the vaccine (Group 1, n=10), unvaccinated pigs (Group 2, n=10) and unvaccinated and non-infectious control pigs (Group 3, n=5)...
February 25, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28238903/responsiveness-to-bronchodilator-procaterol-in-copd-as-assessed-by-forced-oscillation-technique
#11
Satoru Ito, Akemi Uchida, Yoshitaka Isobe, Yoshinori Hasegawa
The aim of this retrospective study was to assess responses to a bronchodilator by forced oscillation technique (FOT) and to relate the results of respiratory impedance (Zrs) to spirometric parameters in patients with chronic obstructive pulmonary disease (COPD). Zrs was measured as a function of frequency from 4 to 36Hz before and after inhalation of procaterol, a short-acting β2-agonist (n=60). Respiratory resistance (Rrs) and reactance (Xrs) were significantly frequency-dependent, and inspiratory and expiratory phases were different both before and after procaterol inhalation...
February 23, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28238741/microparticles-in-nasal-lavage-fluids-in-chronic-rhinosinusitis-potential-biomarkers-for-diagnosis-of-aspirin-exacerbated-respiratory-disease
#12
Toru Takahashi, Atsushi Kato, Sergejs Berdnikovs, Whitney W Stevens, Lydia A Suh, James Norton, Roderick G Carter, Kathleen E Harris, Anju T Peters, Kathryn E Hulse, Leslie C Grammer, Kevin Welch, Stephanie Shintani-Smith, Bruce K Tan, David B Conley, Robert C Kern, Bruce S Bochner, Robert P Schleimer
BACKGROUND: Microparticles (MPs) are submicron sized shed membrane vesicles released from activated or injured cells and are detectable by flow cytometry. MP levels have been utilized as biomarkers to evaluate cell injury or activation in patients with pathological conditions. OBJECTIVE: To compare MP types and levels in nasal lavage fluids (NLFs) from controls and patients with chronic rhinosinusitis without nasal polyps (CRSsNP), CRS with NP (CRSwNP) and aspirin exacerbated respiratory disease (AERD)...
February 23, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28238622/validation-of-the-portuguese-severe-respiratory-insufficiency-questionnaire-for-home-mechanically-ventilated-patients
#13
C Ribeiro, D Ferreira, S Conde, P Oliveira, W Windisch
The aim of this study was to develop and validate the professional translation and cultural adaptation of the Portuguese Severe Respiratory Insufficiency (SRI) Questionnaire. The sample was composed of 93 patients (50 male patients, 53.8%) with a mean age of 66.3 years. The most frequent diagnostic groups were chronic obstructive pulmonary disease, obesity hypoventilation syndrome and restrictive chest wall disorders. The patients were asked to fill in both the SRI and SF-36 questionnaires. Factor analysis of the SRI questionnaire was performed leading to an explained variance of 73%, and resulted in 13 components...
February 23, 2017: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/28238459/linking-sources-to-early-effects-by-profiling-urine-metabolome-of-residents-living-near-oil-refineries-and-coal-fired-power-plants
#14
Chi-Hsin Sally Chen, Tzu-Hsuen Yuan, Ruei-Hao Shie, Kuen-Yuh Wu, Chang-Chuan Chan
BACKGROUND: This study aims at identifying metabolic changes linking external exposure to industrial air toxics with oxidative stress biomarkers. METHODS: We classified 252 study subjects as 111 high vs. 141 low exposure subjects by the distance from their homes to the two main emission sources, oil refineries and coal-fired power plants. We estimated individual's external exposure to heavy metals and polycyclic aromatic hydrocarbons (PAHs) by dispersion and kriging models, respectively...
February 23, 2017: Environment International
https://www.readbyqxmd.com/read/28238433/impact-of-temperature-variation-on-mortality-an-observational-study-from-12-counties-across-hubei-province-in-china
#15
Yunquan Zhang, Chuanhua Yu, Junzhe Bao, Xudong Li
BACKGROUND: Compared with cold- and heat-related health impacts, the evidence was very limited in assessing the mortality effects of temperature variation (TV) accounting for both intra-day and inter-day changes in temperature. OBJECTIVE: We used a newly proposed composite indicator of intra-day and inter-day TV and evaluated TV-mortality associations in Hubei, China at the provincial level. METHODS: Daily mortality and meteorological data during 2009-2012 were obtained from 12 urban and rural counties across Hubei Province in China...
February 23, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28238333/obstructive-sleep-apnea-hypopnea-syndrome-in-patients-with-severe-chronic-respiratory-insufficiency
#16
Ana Hernández Voth, Javier Sayas Catalán, Pedro Benavides Mañas, Alicia de Pablo Gafas, Trinidad Díaz Cambriles, Victoria Villena Garrido
INTRODUCTION AND OBJECTIVE: Although sleep disordered breathing is common in patients with a severe chronic respiratory insufficiency (SCRI), there is few information on its prevalence. Our aim was to describe the prevalence and characteristics of the obstructive sleep apnea-hypopnea syndrome (OSAHS) in these patients. MATERIAL AND METHODS: Prospective and observational study carried out on patients with a SCRI included in a waiting list for a lung transplantation and who had undergone a standard polysomnography...
February 18, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28238276/the-predictive-value-of-an-adjusted-copd-assessment-test-score-on-the-risk-of-respiratory-related-hospitalizations-in-severe-copd-patients
#17
Joanne M Sloots, Christopher A Barton, Julie Buckman, Katherine L Bassett, Job van der Palen, Peter A Frith, Tanja W Effing
We evaluated whether a chronic obstructive pulmonary disease (COPD) assessment test (CAT) with adjusted weights for the CAT items could better predict future respiratory-related hospitalizations than the original CAT. Two focus groups (respiratory nurses and physicians) generated two adjusted CAT algorithms. Two multivariate logistic regression models for infrequent (≤1/year) versus frequent (>1/year) future respiratory-related hospitalizations were defined: one with the adjusted CAT score that correlated best with future hospitalizations and one with the original CAT score...
February 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/28238275/managing-respiratory-disease
#18
Sarah Lunn, Louise Restrick, Myra Stern
The diverse and evolving role of a psychologist within a respiratory multidisciplinary team (MDT) is described, providing a working model for service provision. The rationale for appointing a psychologist within a respiratory MDT is presented first, citing relevant policy and research and outlining the wider psychosocial impact of respiratory disease. This is followed by an insight into the psychologist's role by highlighting important areas, including key therapy themes and the challenge of patient engagement...
February 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/28238229/suspecting-non-cystic-fibrosis-bronchiectasis-what-the-busy-primary-care-clinician-needs-to-know
#19
REVIEW
Diego J Maselli, Bravein Amalakuhan, Holly Keyt, Alejandro A Diaz
AIMS: Non-cystic fibrosis bronchiectasis (NCFB) is a chronic, progressive respiratory disorder characterised by irreversibly and abnormally dilated airways, persistent cough, excessive sputum production and recurrent pulmonary infections. In the last several decades, its prevalence has increased, making it likely to be encountered in the primary care setting. The aim was to review the clinical presentation and diagnosis of NCFB, with an emphasis on the role of computed tomography (CT)...
February 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28238110/electronic-nose-technology-in-respiratory-diseases
#20
REVIEW
Silvano Dragonieri, Giorgio Pennazza, Pierluigi Carratu, Onofrio Resta
Electronic noses (e-noses) are based on arrays of different sensor types that respond to specific features of an odorant molecule, mostly volatile organic compounds (VOCs). Differently from gas chromatography and mass spectrometry, e-noses can distinguish VOCs spectrum by pattern recognition. E-nose technology has successfully been used in commercial applications, including military, environmental, and food industry. Human-exhaled breath contains a mixture of over 3000 VOCs, which offers the postulate that e-nose technology can have medical applications...
February 25, 2017: Lung
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