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spinal hyperostosis

Eijiro Okada, Takashi Tsuji, Kentaro Shimizu, Masanori Kato, Kentaro Fukuda, Shinjiro Kaneko, Jun Ogawa, Kota Watanabe, Ken Ishii, Masaya Nakamura, Morio Matsumoto
PURPOSE: To clarify correlations between spinal fracture and delayed paralysis in patients with diffuse idiopathic skeletal hyperostosis (DISH) using computed tomography (CT) with multiplanar reformatting (CT-MPR). DISH increases susceptibility to unstable spinal fractures, leading to neurological deterioration. The pathomechanism of the neurological injury is unclear. METHODS: This multicenter retrospective study included 42 DISH patients (32 male; 10 female) treated for 45 spinal fractures during a 5-year period...
October 3, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Seil Sohn, Chun Kee Chung, Inbo Han, Sung Bae Park, Hyejin Kim
We aim to compare the bone mineral density (BMD) in a group of patients with cervical or thoracic diffuse idiopathic skeletal hyperostosis (DISH) with that in a matched control group. We also investigated the prevalence of osteoporosis in the two groups and determined the correlation between BMD and the extent of spinal DISH. From 1999 to July 2015, 65 patients with DISH underwent dual-energy X-ray absorptiometry at our institute. The control group was matched with regard to age, sex, and body mass index to the patient group on a 1:1 basis...
October 3, 2016: Journal of Clinical Densitometry
Sachiko Kawasaki, Hideki Shigematsu, Hiroaki Matsumori, Naoki Maegawa, Yasuhito Tanaka
No abstract text is available yet for this article.
August 27, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Jordan J Allensworth, Karla D O'Dell, Joshua S Schindler
BACKGROUND: Diffuse idiopathic skeletal hyperostosis (DISH) is an idiopathic spinal disease common in the elderly and characterized by flowing ossification and osteophyte formation along the spinal column. Cervical hyperostosis is capable of producing dysphagia, stridor, and airway obstruction; however, there are no extant reports of true paralysis of bilateral vocal folds in patients fulfilling the criteria for DISH. METHODS AND RESULTS: We report a case of a 61-year-old man presenting with dysphagia and dyspnea...
August 24, 2016: Head & Neck
Cara L Sedney, Scott D Daffner, Abimbola Obafemi-Afolabi, Daniel Gelb, Steven Ludwig, Sanford E Emery, John C France
BACKGROUND: The operative care of patients with ankylosing spinal conditions such as ankylosing spondylitis (AS) and diffuse idiopathic skeletal hyperostosis (DISH) after a spine fracture is not well represented in the literature. This work seeks to determine the effect of minimally invasive techniques on patients with spinal fractures and ankylosing spinal conditions through a retrospective case-control analysis. METHODS: The operative logs from 1996-2013 of seven fellowship-trained spine surgeons from two academic, Level I trauma centers were reviewed for cases of operatively treated thoracic and lumbar spinal fractures in patients with ankylosing spinal disorders...
2016: International Journal of Spine Surgery
Ioannis Tomos, Aikaterini Vlami, Anna Karakatsani, Ioanna Korbila, Effrosyni D Manali, Spyros A Papiris
Diffuse idiopathic skeletal hyperostosis (DISH), also known as Forestier's disease, is a systemic non inflammatory disease of unknown cause. It is characterized by the presence of osteophytes due to calcification and ossification of spinal ligaments and entheses. Moreover, diffuse idiopathic skeletal hyperostosis has been associated with a variety of metabolic disorders. However, to the best of our knowledge no association with non small cell lung cancer (NSCLC) has been reported so far. In the present study we report a case of a patient with NSCLC and DISH...
2016: Pneumonologia i Alergologia Polska
Hisataka Ii, Sumeeta Warraich, Neil Tenn, Diana Quinonez, David W Holdsworth, James R Hammond, S Jeffrey Dixon, Cheryle A Séguin
Equilibrative nucleoside transporter 1 (ENT1) mediates passage of adenosine across the plasma membrane. We reported previously that mice lacking ENT1 (ENT1(-/-)) exhibit progressive ectopic mineralization of spinal tissues resembling diffuse idiopathic skeletal hyperostosis (DISH) in humans. Here, we investigated mechanisms underlying aberrant mineralization in ENT1(-/-) mice. Micro-CT revealed ectopic mineralization of spinal tissues in both male and female ENT1(-/-) mice, involving the annulus fibrosus of the intervertebral discs (IVDs) of older mice...
September 2016: Bone
Ryoji Tauchi, Sang-Hun Lee, Colleen Peters, Shiro Imagama, Naoki Ishiguro, K Daniel Riew
Study Design Retrospective study. Objectives Assess demographics, ossification characteristics, surgical outcomes, and complications in patients with both diffuse idiopathic spinal hyperostosis (DISH) and ossification of the posterior longitudinal ligament (OPLL) compared with patients who only have OPLL. Methods Clinical charts and radiographs of all patients treated surgically from February 2004 to July 2012 for cervical myeloradiculopathy due to DISH with OPLL or OPLL alone were reviewed retrospectively...
June 2016: Global Spine Journal
Takahito Fujimori, Tadashi Watabe, Yasuo Iwamoto, Seiki Hamada, Motoki Iwasaki, Takenori Oda
STUDY DESIGN: Cross sectional study. OBJECTIVES: To investigate the prevalence, concomitance, and distribution of various types of ossification of the spinal ligaments in healthy subjects using computed tomography (CT). SUMMARY OF BACKGROUND DATA: CT has better diagnostic accuracy for ossification of the spinal ligaments compared to plain radiography. Currently there is no study that examines the prevalence of ossification of the spinal ligaments using whole spine CT scans...
April 23, 2016: Spine
Jonneke S Kuperus, L Anneloes Westerveld, Joost A Rutges, Jacqueline Alblas, Mattie H van Rijen, Ronald L A W Bleys, F Cumhur Oner, Jorrit-Jan Verlaan
Diffuse idiopathic skeletal hyperostosis (DISH) is a predominantly radiographic diagnosis and histological knowledge of DISH is limited. The aim of this study was to describe the histological characteristics of DISH in the spinal column and to study the relation between DISH and intervertebral disc (IVD) degeneration. Therefore, ten human cadaveric spines with fluoroscopic evidence of DISH were compared with ten controls. Plain radiographs and computed tomography (CT) scans were obtained and tissue blocks were resected from three predefined levels of all specimens...
April 21, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Charbel D Moussallem, Brandon A McCutcheon, Michelle J Clarke, Quanqi Cui, Bradford L Currier, Michael J Yaszemski, Paul M Huddleston, Peter S Rose, Brett Freedman, Mark B Dekutoski, Mohamad Bydon, Ahmad Nassr
We compared open stabilization of vertebral fractures to percutaneous spinal fixation techniques in patients with a diagnosis of either ankylosing spondylitis (AS) or diffuse idiopathic skeletal hyperostosis (DISH). A retrospective review of patients known to have AS or DISH treated for spinal column fracture at a single institution between 1995 and 2011 was performed. Patients were analyzed by the type of fixation, divided into either a percutaneous group (PG) or an open group (OG). There were 41 patients identified with a spinal column fracture and history of AS or DISH who received surgical intervention...
August 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Masatoshi Yunoki, Kenta Suzuki, Atsuhito Uneda, Shuichi Okubo, Koji Hirashita, Kimihiro Yoshino
Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by calcification and ossification of the soft tissues, mainly ligaments and entheses. The spines of patients with DISH generally become increasingly rigid and osteoporotic, and fractures may occur after even a relatively minor traumatic event such as a ground-level fall. Moreover, the prevalence of DISH may be rapidly increasing in affluent societies. Thus, awareness of this condition is becoming more important for neurosurgeons when assessing trauma patients...
August 15, 2016: Neurologia Medico-chirurgica
Atsuhiko Hirasawa, Norimitsu Wakao, Mitsuhiro Kamiya, Mikinobu Takeuchi, Katsuhisa Kawanami, Kenta Murotani, Toshihiro Matsuo, Masataka Deie
BACKGROUND: Diffuse idiopathic skeletal hyperostosis (DISH) is prone to be accompanied by a spinal column fracture which is resistant to conservative therapy. This major characteristic of DISH is not recognized adequately by physicians, because the disease's detailed pathological condition has not yet been investigated. Therefore, the purposes of this study were to investigate the prevalence of DISH using computed tomography (CT), and to validate the reliability of CT interpretation. METHODS: Subjects were 558 patients (300 male and 258 female) who underwent both CT of chest to pelvis and x-ray of chest and abdomen from August 2011 to July 2012 at any department other than orthopedic surgery in our institution...
May 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Rasheed Abiola, Paul Rubery, Addisu Mesfin
Study Design Narrative review. Objective To provide an overview on the diagnosis, natural history, and nonoperative and operative management of ossification of the posterior longitudinal ligament (OPLL). OPLL is a multifactorial condition caused by ectopic hyperostosis and calcification of the posterior longitudinal ligament. Familial inheritance and genetic factors have been implicated in the etiology of OPLL. The cervical spine is most commonly affected followed by the thoracic spine. The clinical manifestations range from asymptomatic to myelopathy or myeloradiculopathy...
March 2016: Global Spine Journal
Shinji Tanishima, Chikako Takeda, Yuki Hamamoto, Yasumitsu Kondo, Hideki Nagashima
There is a possibility that the patients with diffuse idiopathic skeletal hyperostosis (DISH) increase with aging of the population and progressive lengthening of life expectancy in developed countries. In the patients with DISH, even a trivial vertebral fracture may actually turn out to be a three-column injury because mechanical stress is applied to the fracture site due to the lever arm effect. Under these circumstances, even a prolonged strict immobilization often results in failure. Recently, elderly people increasingly wish to maintain physical abilities...
November 2012: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Laura Watts, Paul Wordsworth
X linked hypophosphataemia (XLH) is a rare condition with numerous musculoskeletal complications. It may mimic other more familiar conditions, such as vitamin D deficiency, ankylosing spondylitis or diffuse idiopathic skeletal hyperostosis. We describe two cases with Chiari type 1 malformations and syringomyelia, neither of which is well recognised in XLH. The first presented late with the additional complications of spinal cord compression, pseudofracture, renal stones and gross femoroacetabular impingement requiring hip replacement...
2015: BMJ Case Reports
Hiroki Hamano, Masahiko Takahata, Masahiro Ota, Shigeto Hiratsuka, Tomohiro Shimizu, Yusuke Kameda, Norimasa Iwasaki
Diffuse idiopathic skeletal hyperostosis (DISH) is a common skeletal disorder in the elderly, which can develop into periosteal hyperostosis and paradoxically into immobilization-associated trabecular osteoporosis. The bone anabolic agent, teriparatide (TPD), seems to be a rational treatment for the immobilization-associated osteoporosis. However, it can lead to development of hyperostosis lesions in DISH patients. Here, we demonstrate TPD effectively treats trabecular osteoporosis while simultaneously promoting ankylosis of the spine in DISH model tiptoe-walking Yoshimura (twy) mice, compared with the ICR mice...
February 2016: Calcified Tissue International
Alexander C Egerter, Eric S Kim, Darrin J Lee, Jonathan J Liu, Gilbert Cadena, Ripul R Panchal, Kee D Kim
Study Design Retrospective case series. Objective Diffuse idiopathic skeletal hyperostosis (DISH) or Forestier disease involves hyperostosis of the spinal column. Hyperostosis involving the anterior margin of the cervical vertebrae can cause dysphonia, dyspnea, and/or dysphagia. However, the natural history pertaining to the risk factors remain unknown. We present the surgical management of two cases of dysphagia secondary to cervical hyperostosis and discuss the etiology and management of DISH based on the literature review...
October 2015: Global Spine Journal
Shotaro Tsuji, Shinichi Inoue, Toshiya Tachibana, Keishi Maruo, Fumihiro Arizumi, Shinichi Yoshiya
Descriptive case report.To report a rare case of post-traumatic torticollis by odontoid fracture in a patient with diffuse idiopathic skeletal hyperostosis (DISH).Cervical fractures in DISH can result from minor trauma, and a delay in presentation often prevents their timely diagnosis. Cervical fractures in patients with spinal DISH usually occur in extension injuries, and almost always occur in the lower cervical spine. Reports of odontoid fractures with torticollis in patients with spinal DISH are rare.A 73-year-old man with DISH presented with severe neck pain and a cervical deformity presenting as torticollis without neurological deficits...
September 2015: Medicine (Baltimore)
Alexander Schuh, Aleksey Shishkov, Stefanie Füssel, Ute Drexler
No abstract text is available yet for this article.
August 20, 2015: MMW Fortschritte der Medizin
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