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JOURNAL ARTICLE
Zhongyuan He, Nguyen Tran Canh Tung, Yasuhito Yahara, Hiroto Makino, Taketoshi Yasuda, Shoji Seki, Kayo Suzuki, Hayato Futakawa, Katsuhiko Kamei, Yoshiharu Kawaguchi
OBJECTIVE: To investigate the relationship between the severity and morphology of heterotopic ossification in the spinal ligaments including sacroiliac (SI) joints, and serum interleukin-17 (IL-17) levels in patients with ossification of the posterior longitudinal ligament (OPLL) with or without diffuse idiopathic skeletal hyperostosis (DISH), as well as a non-OPLL group. METHODS: A total of 103 patients with OPLL (DISH (-), n = 50; DISH (+), n = 53) and 53 age- and gender-matched controls were included...
October 27, 2023: Rheumatology
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JOURNAL ARTICLE
Kazuma Ohshima, Hiroaki Nakashima, Naoki Segi, Sadayuki Ito, Jun Ouchida, Yasuhiko Takegami, Shinya Ishizuka, Yukiharu Hasegawa, Shiro Imagama
BACKGROUND: The incidence of diffuse idiopathic skeletal hyperostosis (DISH) is increasing with the aging of the population. Asymptomatic DISH can decrease the spinal range of motion (ROM) and cause fractures. However, the prevalence or physical function of patients with DISH before experiencing fractures and other serious conditions is unclear. This study aimed to investigate the prevalence of DISH in the community residents on the basis of age and sex and characterize their physical function, ROM, and bone fragility...
October 21, 2023: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
#23
JOURNAL ARTICLE
Giuseppe R Giammalva, Rosario Maugeri, Luigi M Cusimano, Andrea S Sciortino, Lapo Bonosi, Lara Brunasso, Roberta Costanzo, Francesco Signorelli, Silvana Tumbiolo, Domenico G Iacopino, Massimiliano Visocchi
CONTEXT: Diffuse idiopathic skeletal hyperostosis (DISH) or Forestier's syndrome may reduce vertebral mobility, thus affecting the stability of adjacent vertebral segments and promoting spinal stenosis, vertebral dislocation, and unstable fracture secondary to low-energy trauma. AIMS: This study aimed to contribute with a case series of three patients affected by DISH undergone surgery with occipitocervical fixation for craniovertebral junction (CVJ) instability since the poor literature about CVJ instability and surgery in patients affected by DISH...
2023: Journal of Craniovertebral Junction and Spine
#24
Mohammad Al-Jafari, Sarah Abu Tapanjeh, Harith Al-Azzawi, Sura Abu Eid, Huda J Baidoun, Mohammad Abu-Jeyyab, Mohammed Y Sarhan, Hiba Jbara, Alaa Akel
Diffuse idiopathic skeletal hyperostosis (DISH) is a condition that causes abnormal bone growth at the sites of ligament insertion, mainly in the spine. It is of unknown etiology and usually affects older males. It is often asymptomatic, but it can sometimes cause dysphagia if it affects the anterior cervical spine. We report the case of a 50-year-old male patient with DISH who presented with chronic dysphagia and was diagnosed with a large cervical osteophyte compressing the esophagus. The patient had a history of several comorbidities, including diabetes, hypertension, stroke, and gout...
September 2023: Curēus
#25
Farzin Davoodi, Narges Bazgir, Reza Naseri
BACKGROUND: Diffuse idiopathic skeletal hyperostosis (DISH) is a rare noninflammatory disorder impacting spinal longitudinal ligament and enthesis. The majority of DISH cases are asymptomatic or have few manifestations. Manifestations include neck pain and stiffness, stridor, breathing disturbances, and dysphagia. Case Presentation . A mid-aged man with progressive dysphagia to solid food was admitted to Loghman Hakim Hospital. In cervical X-ray, a huge ossification in the anterior longitudinal ligament was evident...
2023: Case Reports in Radiology
#26
JOURNAL ARTICLE
Shusuke Hagihara, Hideki Ohta, Jun Tanaka, Teruaki Shiokawa, Yoshikuni Kida, Yohei Iguchi, Masato Tatsumi, Ryo Shibata, Kenichi Tahara, Tatsuya Shibata, Kyoichi Sanada, Takuaki Ymamoto
STUDY DESIGN: This study adopted a retrospective cohort study design. PURPOSE: This study aimed to clarify the influence of diffuse idiopathic skeletal hyperostosis (DISH) on bone fusion after transforaminal lumbar interbody fusion (TLIF). OVERVIEW OF LITERATURE: The negative effects of DISH on lumbar degenerative diseases have been reported, and DISH may be involved in the onset and severity of lumbar spinal canal stenosis. Patients with DISH have significantly more reoperations after posterior lumbar fusion, including TLIF...
October 4, 2023: Asian Spine Journal
#27
JOURNAL ARTICLE
Haicheng Zhou, Hongpan Xu, Jianmin Gong, Zhiyang Li, Xu Sun
The primary objective of this study was to determine the role of fibroblast growth factor 23 (FGF-23) in the pathogenesis of diffuse idiopathic skeletal hyperostosis (DISH). A total of 61 patients with DISH and 61 age- and sex-matched control patients without DISH were included in this study. The serum FGF-23, creatinine, inorganic phosphate, calcium, albumin, albumin-adjusted calcium and alkaline phosphatase, and C-reactive protein were assessed in both groups. Based on the extent of ossification, DISH group was further divided into T-DISH and L-DISH subgroups...
September 19, 2023: Calcified Tissue International
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JOURNAL ARTICLE
Tomoaki Shimizu, Kota Suda, Satoko Matsumoto Harmon, Miki Komatsu, Masahiro Ota, Hiroki Ushirozako, Akio Minami, Masahiko Takahata, Norimasa Iwasaki, Hiroshi Takahashi, Masashi Yamazaki
This retrospective study aimed to investigate the characteristics of patients with cervical spinal cord injuries (CSCI) with diffuse idiopathic skeletal hyperostosis (DISH). We included 153 consecutive patients with CSCI who underwent posterior decompression and fusion surgery. The patients were divided into two groups based on the presence of DISH. Patient characteristics, neurological status on admission, nutritional status, perioperative laboratory variables, complications, neurological outcomes at discharge, and medical costs were compared between the groups...
September 1, 2023: Journal of Clinical Medicine
#29
JOURNAL ARTICLE
Haojie Chen, Qingshuang Zhou, Sinian Wang, Xiaojiang Pu, Haicheng Zhou, Bin Wang, Zezhang Zhu, Yong Qiu, Xu Sun
OBJECTIVE: Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by osteophytes in the anterior vertebrae, and the presence of aorta may have an impact on their formation. However, the anatomical positional relationship between the aorta and osteophytes in patients with DISH remains controversial. This study aimed to evaluate the position of osteophytes in relation to aorta in DISH, and the influence of aortic pulsation on the formation of osteophytes from the perspective of morphology...
November 2023: Orthopaedic Surgery
#30
JOURNAL ARTICLE
Urara Kuwae, Takeo Harada, Ryoichi Shibuya, Takeshi Fuji
Early operative fixation is widely recognized as essential for managing spinal fractures in patients with diffuse idiopathic skeletal hyperostosis (DISH). However, no report to date has addressed the occurrence of minimal vertebral fractures diagnosable only through magnetic resonance imaging (MRI) in these patients and the associated temporal changes in the fracture site. In this report, we describe a rare clinical case involving an 81-year-old man who developed progressive spinal destruction secondary to a minimal vertebral fracture...
September 2023: Journal of International Medical Research
#31
JOURNAL ARTICLE
Ryosuke Hirota, Atsushi Teramoto, Mitsunori Yoshimoto, Hiroyuki Takashima, Naomi Yasuda, Arihiko Tsukamoto, Noriyuki Iesato, Makoto Emori, Kousuke Iba, Nobuyoshi Kawaharada, Toshihiko Yamashita
Diffuse idiopathic skeletal hyperostosis (DISH) is a noninflammatory spondyloarthropathy characterized by ectopic calcification of spinal cord tissue. Its etiology is possibly polygenic. However, its pathogenesis and systemic effects remain unclear. Recent studies have reported a high prevalence of DISH in heart failure patients. The authors investigated how the incidence and severity of DISH are associated with vascular calcification and the occurrence of cardiovascular events. In this retrospective chart review study, 500 patients with cardiovascular disease who underwent surgery (cardiovascular events group) and 500 patients with non-cardiovascular disease who underwent computed tomography scans (non-cardiovascular events group) were randomly selected to investigate the degree of ossification of the anterior longitudinal ligament and the incidence of DISH...
August 20, 2023: Journal of Clinical Medicine
#32
JOURNAL ARTICLE
Haicheng Zhou, Sinian Wang, Nannan Wang, Haojie Chen, Bin Wang, Yong Qiu, Zezhang Zhu, Xu Sun
OBJECTIVE: To compare the differences of spinopelvic morphology among patients with DISH, patients without DISH and normal elderly and to assess the impact of ossification extent on sagittal alignment. METHODS: Patients with and without DISH aged > 50 years who required surgery because of lumbar spinal stenosis were enrolled in this cohort(DISH and Non-DISH groups). Also, we collected age-matched normal old outpatients as the control group(Normal group)...
August 11, 2023: Clinical Neurology and Neurosurgery
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REVIEW
Hajime Kato, Demetrios T Braddock, Nobuaki Ito
PURPOSE OF REVIEW: The study aims to provide updated information on the genetic factors associated with the diagnoses 'Diffuse Idiopathic Skeletal Hyperostosis' (DISH), 'Ossification of the Posterior Longitudinal Ligament' (OPLL), and in patients with spinal ligament ossification. RECENT FINDINGS: Recent studies have advanced our knowledge of genetic factors associated with DISH, OPLL, and other spinal ossification (ossification of the anterior longitudinal ligament [OALL] and the yellow ligament [OYL])...
October 2023: Current Osteoporosis Reports
#34
JOURNAL ARTICLE
Mitsuru Furukawa, Kanehiro Fujiyoshi, Toshiki Okubo, Yoshihide Yanai, Kohei Matsubayashi, Takashi Kato, Yoshiomi Kobayashi, Tsunehiko Konomi, Yoshiyuki Yato
STUDY DESIGN: This study adopted a cross-sectional study design. PURPOSE: This study was designed to investigate the effects of bone cross-link bridging on fracture mechanism and surgical outcomes in vertebral fractures using the maximum number of vertebral bodies with bony bridges between adjacent vertebrae without interruption (maxVB). OVERVIEW OF LITERATURE: The complex interplay of bone density and bone bridging in the elderly can complicate vertebral fractures, necessitating a better understanding of fracture mechanics...
July 6, 2023: Asian Spine Journal
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JOURNAL ARTICLE
Naoki Segi, Hiroaki Nakashima, Masaaki Machino, Sadayuki Ito, Noriaki Yokogawa, Takeshi Sasagawa, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Kota Watanabe, Satoshi Nori, Kazuki Takeda, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Hidetomi Terai, Koji Tamai, Eiki Shirasawa, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Haruki Funao, Yasushi Oshima, Toshitaka Yoshii, Takashi Kaito, Daisuke Sakai, Tetsuro Ohba, Shoji Seki, Bungo Otsuki, Masayuki Ishihara, Masashi Miyazaki, Seiji Okada, Shiro Imagama, Satoshi Kato
STUDY DESIGN: Retrospective multicenter study. OBJECTIVE: The purpose of this study was to compare the prognosis of elderly patients with injuries related to cervical diffuse idiopathic skeletal hyperostosis (cDISH) to matched control for each group, with and without fractures. METHODS: The current multicenter study was a retrospective analysis of 140 patients aged 65 years or older with cDISH-related cervical spine injuries; 106 fractures and 34 spinal cord injuries without fracture were identified...
July 3, 2023: Global Spine Journal
#36
JOURNAL ARTICLE
Riku M Vierunen, Ville V Haapamäki, Mika P Koivikko, Frank V Bensch
OBJECTIVES: To determine the incidence of spinal hematoma and its relation to neurological deficit after trauma in patients with spinal ankylosis from diffuse idiopathic skeletal hyperostosis (DISH). MATERIALS AND METHODS: A retrospective review of 2256 urgent or emergency MRI referrals over a period of 8 years and nine months revealed 70 DISH patients who underwent CT and MRI scans of the spine. Spinal hematoma was the primary outcome. Additional variables were spinal cord impingement, spinal cord injury (SCI), trauma mechanism, fracture type, spinal canal narrowing, treatment type, and Frankel grades during injury, before and after treatment...
June 29, 2023: European Radiology
#37
JOURNAL ARTICLE
Norihiro Nishida, Muzammil Mumtaz, Sudharshan Tripathi, Yogesh Kumaran, Amey Kelkar, Takashi Sakai, Vijay K Goel
OBJECTIVE: Lumbar spinal canal stenosis (LSS) with diffuse idiopathic skeletal hyperostosis (DISH) can require revision surgery due to the intervertebral instability after decompression. However, there is a lack of mechanical analyses for decompression procedures for LSS with DISH. METHODS: This study employed a validated, three-dimensional finite element model of a L1-L5 lumbar spine, L1-L4 DISH, pelvis, and femurs to compare the biomechanical parameters (range of motion (ROM), intervertebral disc, hip joint, and instrumentation stresses) with a L5-sacrum (L5-S) and L4-S posterior lumbar interbody fusion (PLIF)...
May 24, 2023: World Neurosurgery
#38
JOURNAL ARTICLE
Atsushi Tanaka, Takayoshi Shimizu, Toshiyuki Kawai, Shunsuke Fujibayashi, Koichi Murata, Shuichi Matsuda, Bungo Otsuki
PURPOSE: Patients with diffuse idiopathic skeletal hyperostosis (DISH) that extends to the lumbar segments (L-DISH) have a high risk of further surgery after lumbar decompression. However, few studies have focused on the ankylosis status of the residual caudal segments, including the sacroiliac joint (SIJ). We hypothesized that patients with more ankylosed segments beside the operated level, including the SIJ, would be at a higher risk of further surgery. METHODS: A total of 79 patients with L-DISH who underwent decompression surgery for lumbar stenosis at a single academic institution between 2007 and 2021 were enrolled...
May 23, 2023: European Spine Journal
#39
JOURNAL ARTICLE
Caroline Schwarz, Michael Schwarz, Victor Schmidbauer, Franz Kainberger, Ruxandra-Iulia Milos, Herbert Langenberger, Irina Gessl, Georg Funk, Michael Gschwantler
BACKGROUND: Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by ankylosing spinal alterations which are often asymptomatic but may typically cause back pain and spinal stiffness. Presence of DISH may complicate spinal trauma and lead to unstable fractures requiring surgical intervention. Treatment options include physical activity, symptomatic treatment, local heat application, and optimization of metabolic comorbidities. CASE: A multimorbid older patient was admitted to the gastroenterological ward for the investigation of progressive dysphagia and weight loss...
May 5, 2023: Wiener Klinische Wochenschrift
#40
JOURNAL ARTICLE
Dale E Fournier, Matthew A Veras, Courtney R Brooks, Diana Quinonez, Magali Millecamps, Laura S Stone, Cheryle A Séguin
BACKGROUND: Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by progressive calcification of spinal tissues; however, the impact of calcification on pain and function is poorly understood. This study examined the association between progressive ectopic spine calcification in mice lacking equilibrative nucleoside transporter 1 (ENT1-/- ), a preclinical model of DISH, and behavioral indicators of pain. METHODS: A longitudinal study design was used to assess radiating pain, axial discomfort, and physical function in wild-type and ENT1-/- mice at 2, 4, and 6 months...
April 29, 2023: Arthritis Research & Therapy
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