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Alex R Wessel, Brett D Crist, James P Stannard, Gregory J Della Rocca, Aaron M Stoker, Chantelle C Bozynski, Cristi R Cook, Keiichi Kuroki, Carin E Ahner, James L Cook
PURPOSE: Previous studies indicate that Reamer Irrigator Aspirator (RIA) filtrate contains proteins that have the potential to stimulate bone healing. This study aimed to determine the osteoinductive capabilities of RIA filtrate in a validated in vivo model. METHODS: With Institutional Review Board approval, RIA filtrates from 9 patients were collected. The filtrate was processed to remove cells and inorganic particles. A portion of each sample was set aside for protein analysis while the remainder was lyophilized and prepared for implantation...
April 17, 2018: Injury
P M Pires, T P Santos, A Fonseca-Gonçalves, M M Pithon, R T Lopes, A A Neves
AIM: To test the hypothesis that polyacrylic acid-based and calcium silicate materials are able to increase mineral density of artificially demineralized dentine produced by a microcosm model for caries formation. METHODOLOGY: Forty-five dentine cavities were prepared in 9 sound human third molars (5 in each tooth). Specimens received a bacterial inoculum and were incubated in BHI plus 5% of sucrose for 96h to allow biofilm formation. After that, the specimens were scanned in a high energy micro-CT (baseline stack) and then, each cavity was filled with different cements: zinc polycarboxylate (Poly Zinc™ , Prevest DenPro, Jammu, India), conventional glass ionomer (Ketac Molar, 3M ESPE, Seefeld, Germany) and two calcium silicate based materials (MTA, Angelus, Londrina, Brazil and Biodentine™ , Septodont, Saint Maur des Fosses, France) while the central cavity was filled with utility wax (negative control)...
April 22, 2018: International Endodontic Journal
Eun-Bin Bae, Keun-Ho Park, Jin-Hyung Shim, Ho-Yun Chung, Jae-Won Choi, Jin-Ju Lee, Chang-Hwan Kim, Ho-Jun Jeon, Seong-Soo Kang, Jung-Bo Huh
This study was undertaken to evaluate the effect of 3D printed polycaprolactone (PCL)/ β -tricalcium phosphate ( β -TCP) scaffold containing bone demineralized and decellularized extracellular matrix (bdECM) and human recombinant bone morphogenetic protein-2 (rhBMP-2) on bone regeneration. Scaffolds were divided into PCL/ β -TCP, PCL/ β -TCP/bdECM, and PCL/ β -TCP/bdECM/BMP groups. In vitro release kinetics of rhBMP-2 were determined with respect to cell proliferation and osteogenic differentiation. These three reconstructive materials were implanted into 8 mm diameter calvarial bone defect in male Sprague-Dawley rats...
2018: BioMed Research International
Thiago Isidro Vieira, João Victor Frazão Câmara, Júlia Gabiroboertz Cardoso, Adílis Kalina Alexandria, Andréa Vaz Braga Pintor, Jaqueline Correia Villaça, Lúcio Mendes Cabral, Maria Teresa Villela Romanos, Andrea Fonseca-Gonçalves, Ana Maria Gondim Valença, Lucianne Cople Maia
OBJECTIVE: This study evaluated the cytotoxicity, antimicrobial activity and in vitro influence of new fluoridated nanocomplexes on dental demineralization. DESIGN: The nanocomplexes hydroxypropyl-β-cyclodextrin with 1% titanium tetrafluoride (TiF4 ) and γ-cyclodextrin with TiF4 were compared to a positive control (TiF4 ), a blank control (without treatment) and negative controls (hydroxypropyl-β-cyclodextrin, γ-cyclodextrin, deionized water), following 12- and 72-hour complexation periods...
April 13, 2018: Archives of Oral Biology
Yingqi Chen, Sang-Ho Ye, Hideyoshi Sato, Yang Zhu, Vesselin Shanov, Tarannum Tiasha, Antonio D'Amore, Samuel Luketich, Guojiang Wan, William R Wagner
The challenge of developing scaffolds to reconstruct critical-sized calvarial defects without the addition of high levels of exogenous growth factor remains relevant. Both osteogenic regenerative efficacy as well as suitable mechanical properties for the temporary scaffold system are of importance. In this study, a Mg alloy mesh reinforced polymer/demineralized bone matrix (DBM) hybrid scaffold was designed where the hybrid scaffold was fabricated by a concurrent electrospinning/electrospraying of poly(lactic-co-glycolic) (PLGA) polymer and DBM suspended in hyaluronic acid (HA)...
April 20, 2018: Journal of Tissue Engineering and Regenerative Medicine
M Ando, S Shaikh, G Eckert
Caries lesion progression is difficult to determine with visual and tactile examinations. The hypothesis of this study was that reflection and roughness measurements could determine caries progression. Ground/polished sound human enamel specimens were analyzed at baseline (sound) and after two four-day demineralization periods for reflection using optical reflectometry (ORef) and for roughness using optical surface profilometry (SPro). Specimens were demineralized using a microbial- Streptococcus mutans aries model...
May 2018: Operative Dentistry
E C Bridi, A A Leme-Kraus, B Aydin, R T Basting, A K Bedran-Russo
OBJECTIVE: The purpose of this study was to investigate the effects of aqueous solutions of different concentrations of titanium tetrafluoride (TiF4 ) on dentin matrix stability up to six months. DESIGN: Dentin specimens prepared from fifteen nonerupted molars were demineralized and randomly distributed into groups: 2.5% TiF4 , 4% TiF4, 1000 ppm NaF, and control (distilled water). The modulus of elasticity (ME) and dry masses of the dentin matrix were determined at baseline, and up to 6 months following treatment...
April 10, 2018: Archives of Oral Biology
Ana Carolina Bosco Mendes, Manuel Restrepo, Elcilaine Rizzato Azevedo, Rita De Cássia Loiola Cordeiro, Lourdes Santos-Pinto, Angela Cristina Cilense Zuanon
PURPOSE: To evaluate the effect of two molar clamps on artificially demineralized enamel of permanent teeth after three periods of isolation. METHODS: Twenty extracted third molars were immersed in a biological solution for development of artificial white spot lesions and then were equally divided into two groups according to the clamp being placed (Group G205: clamp no. 205; Group G26: clamp no. 26). The loss of fluorescence and lesion area of demineralized surface after each isolation were assessed by quantitative light-induced fluorescence...
January 15, 2018: Journal of Dentistry for Children
Thiago Henrique Scarabello Stape, Leo Tjäderhane, Gabriel Abuna, Mário Alexandre Coelho Sinhoreti, Luís Roberto Marcondes Martins, Arzu Tezvergil-Mutluay
OBJECTIVE: To determine whether bonding effectiveness and hybrid layer integrity on acid-etched dehydrated dentin would be comparable to the conventional wet-bonding technique through new dentin biomodification approaches using dimethyl sulfoxide (DMSO). METHODS: Etched dentin surfaces from extracted sound molars were randomly bonded in wet or dry conditions (30s air drying) with DMSO/ethanol or DMSO/H2 O as pretreatments using a simplified (Scotchbond Universal Adhesive, 3M ESPE: SU) and a multi-step (Adper Scotchbond Multi-Purpose, 3M ESPE: SBMP) etch-and-rinse adhesives...
April 13, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
Mohamed-Nur Abdallah, Ghada Abughanam, Simon D Tran, Zeeshan Sheikh, Mohamed A Mezour, Tayebah Basiri, Yizhi Xiao, Marta Cerruti, Walter L Siqueira, Faleh Tamimi
Titanium (Ti) dental implants are susceptible to bacterial infections and failure due to lack of proper epithelial seal. Epithelial cells establish a strong epithelial seal around natural teeth by the deposition of basal lamina (BL) proteins that adsorb on the tooth surface. This seal can even be re-established onto cementum or dentin following injury or periodontal therapy. However, it is unclear how tooth surfaces promote this cell attachment and protein adsorption. Understanding the interactions between BL proteins and epithelial cells with dentin and Ti will facilitate the development of implant surfaces that promote the formation of an epithelial seal and improve the success of periodontal therapy and wound healing on natural teeth...
April 13, 2018: Acta Biomaterialia
Rodrigo A Giacaman, Vanesa Pailahual, Natalia Díaz-Garrido
Objectives: Frequent consumption of sugars-containing carbonated beverages has been associated with caries, but the consequences on the dental biofilm remain unclear. The aim was to evaluate the effect of commercial carbonated beverages and their sugar-free version on enamel and dentine demineralization and on the cariogenic properties of Streptococcus mutans biofilms. Materials and Methods: Biofilms of S. mutans UA159 were grown on enamel and dentin slabs and exposed 3 times/day for 5 min, to a commercial cola or orange-flavored carbonated beverage or to their sugar-free version...
January 2018: European Journal of Dentistry
Tobias Basler, Nadja Naenni, David Schneider, Christoph H F Hämmerle, Ronald E Jung, Daniel S Thoma
OBJECTIVES: To assess two- and three-dimensional changes of the peri-implant tissues as well as clinical, biological, and radiological outcomes of implants having been treated with resorbable or nonresorbable membranes at 3 years. MATERIALS AND METHODS: Twenty-three patients were re-examined after having received a single-tooth implant in the esthetic zone in conjunction with guided bone regeneration (GBR) using either a resorbable (RES) or a titanium-reinforced nonresorbable membrane (N-RES) and demineralized bovine bone mineral...
April 15, 2018: Clinical Oral Implants Research
Francisco Samuel Rodrigues Carvalho, Victor Pinheiro Feitosa, Paulo Goberlânio de Barros Silva, Eduardo Costa Studart Soares, Thyciana Rodrigues Ribeiro, Cristiane Sá Roriz Fonteles, Fábio Wildson Gurgel Costa
PURPOSE: To evaluate different therapeutic Carnoy's solution formulations on hard human tissues. MATERIALS AND METHODS: An in vitro study was performed with human teeth (n = 36) and bone fragments (n = 18), randomly divided into two experimental groups (Group I = Carnoy solution with chloroform; Group II = Carnoy solution without chloroform) and a control group (saline solution). The groups were subdivided into pre-conditioning, post-conditioning, and post-conditioning with saline washing...
February 21, 2018: Journal of Cranio-maxillo-facial Surgery
Juliana Gonçalves Pires, Sara Salustiano Zabini, Aline Silva Braga, Rita de Cássia Fabris, Flaviana Bombarda de Andrade, Rodrigo Cardoso de Oliveira, Ana Carolina Magalhães
OBJECTIVES: This study evaluated the effect of the hydroalcoholic extracts of Myracrodruon urundeuva All. and Qualea grandiflora Mart. leaves (alone or combined) on the viability of Streptococcus mutans biofilm and on the prevention of enamel demineralization. METHODS: Strain of S. mutans (ATCC 21175) was reactivated in BHI broth. Minimum inhibitory concentration, minimum bactericidal concentration, minimum inhibition biofilm concentration and minimum eradication biofilm concentration were determined in order to choose the concentrations to be tested under biofilm model...
April 6, 2018: Archives of Oral Biology
George M Weisz, Konrad Kwiet
The discovery of Jewish babies who were born in Nazi concentration camps and survived seems miraculous, but this phenomenon did occur toward the end of World War II. The lives of a small group of mothers and surviving children are of both historical and medical interests. Their survival shows additional support for the hypothesis that maternal nutrition can induce metabolic syndrome and bone demineralization in their offspring. Information obtained through direct contact with some of the surviving children is the basis for this article...
April 2018: Israel Medical Association Journal: IMAJ
Alizae Marny Mohamed, Kiong Hung Wong, Wan Jen Lee, Murshida Marizan Nor, Haizal Mohd Hussaini, Tanti Irawati Rosli
Aim: The aim of the study was to evaluate the effect of resin infiltration on colour changes and surface roughness of artificial white spot lesions (WSLs) on maxillary and mandibular premolar. Materials and methods: Sixty (60) extracted sound Maxilla (Mx) and Mandibular (Mn) premolars were randomly divided into 2 groups (test and control). Artificial WSLs were produced on buccal surface of teeth and were immersed in artificial saliva for 8 weeks. Colour components (L∗ , a∗ , b∗ ) and surface roughness (Sa∗ ) were assessed on 40 teeth using colour difference meter RD-100 and Alicona® Infinite Focus profilometer respectively...
April 2018: Saudi Dental Journal
Vivian Leite Martins, Rodrigo Vitoria da Costa Ramos, Max José Pimenta Lima, Roberto Paulo Correia de Araújo, Andrea Nóbrega Cavalcanti
Context: Eroded dentin might present the opening of dentinal tubules, increasing permeability, and consequently dentinal hypersensitivity. Aims: This study evaluated the permeability of dentin surfaces exposed to different levels of erosion and methods of surface protection. Materials and Methods: Dentine samples (3 mm × 3 mm × 1 mm) were prepared from bovine incisors ( n = 90) and divided into three groups according to the method of controlling erosive challenge: Negative control, topical fluoride application, and glass ionomer sealant...
January 2018: Journal of Conservative Dentistry: JCD
Jie Zhang, Mi Feng, Xingmei Lu, Chunyan Shi, Xiaoqian Li, Jiayu Xin, Guikuan Yue, Suojiang Zhang
Low molecular weight (LMW) chitin exhibits antimicrobial activity, and its preparation generally employs high molecular weight chitin as raw material. Here we use raw crab shell as material to isolate LMW-chitin. The raw crab shell was treated with hydrochloric acid under different conditions, and the demineralization and deproteinization of acid to the raw and demineralized crab shell were examined. Under conditions of 3-5 wt% acid, 110 °C, and 180-600 min, the obtained LMW-chitin owns 92% purity and 53-80 kDa molecular weight...
June 15, 2018: Carbohydrate Polymers
Jae-Hyun Jung, Dong-Hyun Kim, Kyung-Hyeon Yoo, Seog-Young Yoon, Yeon Kim, Moon-Kyoung Bae, Jin Chung, Ching-Chang Ko, Yong Hoon Kwon, Yong-Il Kim
OBJECTIVES: To synthesize a silver-doped bioactive glass/mesoporous silica nanoparticle (Ag-BGN@MSN), as well as to investigate its effects on dentinal tubule occlusion, microtensile bond strength (MTBS), and antibacterial activity. MATERIALS AND METHODS: Ag-BGN@MSN was synthesized using a modified "quick alkali-mediated sol-gel" method. Demineralized tooth disc models were made and divided into four groups; the following treatments were then applied: group 1-no treatment, group 2-bioglass, group 3-MSN, group 4-Ag-BGN@MSN...
April 6, 2018: Clinical Oral Investigations
Xiping Xu, Dong-Seok Sohn, Hyung-Gyun Kim, Sang-Jae Lee, Yong-Suk Moon
PURPOSE: The aim of this animal study is to evaluate, by histomorphometric analysis, new bone formation in rabbit maxillary sinuses with Bio-Oss and demineralized particulate human tooth graft. MATERIALS AND METHODS: Bilateral sinus augmentation procedures were performed in 8 adult male rabbits. After preparation of replaceable bony windows on the lateral wall of the nasal cavity with a piezoelectric surgical device, deproteinized bovine graft (Bio-Oss) was grafted in the new compartment of the maxillary sinus after elevation of the sinus membrane in the control group...
April 2, 2018: Implant Dentistry
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