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https://www.readbyqxmd.com/read/28437653/effects-of-acidic-and-neutral-biochars-on-properties-and-cadmium-retention-of-soils
#1
Fangjie Qi, Zhaomin Dong, Dane Lamb, Ravi Naidu, Nanthi S Bolan, Yong Sik Ok, Cuixia Liu, Naser Khan, M A H Johir, Kirk T Semple
In this study, an acidic biochar and a neutral biochar were applied at 5 wt% into two soils for an 11-month incubation experiment. One Ferrosol soil (Ba) was slightly acidic with low organic matter and the other Dermosol soil (Mt) was slightly alkaline with high organic matter. The acidic (pH = 3.25) wood shaving (WS) biochar had no marked impact on nutrient levels, cation exchange capacity (CEC), pH and acid neutralization capacity (ANC) of either soil. By contrast, the neutral (pH = 7.00) chicken litter (CL) biochar significantly increased major soluble nutrients, pH, ANC of soil Ba...
April 5, 2017: Chemosphere
https://www.readbyqxmd.com/read/28437576/irisin-and-musculoskeletal-health
#2
Graziana Colaianni, Saverio Cinti, Silvia Colucci, Maria Grano
Irisin is a hormone-like myokine produced in abundance by skeletal muscle in response to exercise, both in mice and humans. Once released into the circulation, irisin acts on white adipocytes to induce the browning response and subsequently activates nonshivering thermogenesis. We have examined the premise that irisin produced during exercise may subserve further functions in the musculoskeletal system. We review evidence for its possible skeletal effects, including the central role that irisin plays in the control of bone mass, with positive effects on cortical mineral density and geometry in mice...
April 24, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28435460/size-dependent-effects-of-gold-nanoparticles-on-osteogenic-differentiation-of-human-periodontal-ligament-progenitor-cells
#3
Yangheng Zhang, Na Kong, Yuanchao Zhang, Wenrong Yang, Fuhua Yan
Gold nanoparticles (AuNPs) have been reported to promote osteogenic differentiation of mesenchymal stem cells and osteoblasts, but little is known about their effects on human periodontal ligament progenitor cells (PDLPs). In this study, we evaluated the effects of AuNPs with various diameters (5, 13 and 45 nm) on the osteogenic differentiation of PDLPs and explored the underlying mechanisms. 5 nm AuNPs reduced the alkaline phosphatase activity, mineralized nodule formation and expression of osteogenic genes, while 13 and 45 nm AuNPs increased these osteogenic markers...
2017: Theranostics
https://www.readbyqxmd.com/read/28427101/tanshinol-alleviates-osteoporosis-and-myopathy-in-glucocorticoid-treated-rats
#4
Guanghua Chen, Xinle Zhang, Han Lin, Guizhi Huang, Yahui Chen, Liao Cui
Tanshinol is a major water-soluble active component of Salvia miltiorrhiza. In this study, we aimed to investigate whether tanshinol has potential therapeutic effects against glucocorticoid-induced osteoporosis and glucocorticoid-induced myopathy. Ninety-six female Sprague-Dawley rats were randomly assigned to five groups: a control group, a model group, and three model groups treated with 25 or 50 mg/kg of tanshinol, or calcitriol. All model groups received prednisone acetate for 90 days to induce glucocorticoid-induced osteoporosis...
April 20, 2017: Planta Medica
https://www.readbyqxmd.com/read/28421987/a-new-dispersive-liquid-liquid-microextraction-method-for-preconcentration-and-determination-of-aluminum-iron-copper-and-lead-in-real-water-samples-by-hplc
#5
Güzin Alpdoğan, Şule Dinç Zor
In this study, dispersive liquid–liquid microextraction coupled with HPLC with variable-wavelength detectionwas applied for the simultaneous determination of Al, Fe, Cu, and Pb in various water samples at trace levels. In the proposed method, all the system parameters in both the extraction and separation/determination steps, such as extraction and disperser solvent type and their volumes, complexing reagent concentration, salt addition, extraction and centrifugation times, and pH, were optimized to get not only high extraction efficiency but also lower LODs for the analytes...
April 18, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28416991/can-denosumab-be-a-substitute-competitor-or-complement-to-bisphosphonates
#6
REVIEW
Su Young Kim, Hwoe Gyeong Ok, Christof Birkenmaier, Kyung Hoon Kim
Osteoblasts, originating from mesenchymal cells, make the receptor activator of the nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG) in order to control differentiation of activated osteoclasts, originating from hematopoietic stem cells. When the RANKL binds to the RANK of the pre-osteoclasts or mature osteoclasts, bone resorption increases. On the contrary, when OPG binds to the RANK, bone resorption decreases. Denosumab (AMG 162), like OPG (a decoy receptor), binds to the RANKL, and reduces binding between the RANK and the RANKL resulting in inhibition of osteoclastogenesis and reduction of bone resorption...
April 2017: Korean Journal of Pain
https://www.readbyqxmd.com/read/28414988/response-of-mandibular-condyles-of-juvenile-and-adult-rats-to-abnormal-occlusion-and-subsequent-exemption
#7
Guang Zeng, Bin Kuang, Wen-Xing Xun, Gao-Tong Ren, Ke-Wen Wei
OBJECTIVE: The adaptation capacities of the mandibular condyle in response to mechanical stimuli might be different between juveniles and adults, but has not been compared. This study aimed to investigate whether abnormal molar occlusion and subsequent molar extraction could lead to different remodeling responses in the mandibular condyles of juvenile and adult rats. METHODS: Abnormal molar occlusion (AMO) was established in the 5- and 16-wk old rats by moving their maxillary left and mandibular right third molars distally...
March 28, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28409410/synergistic-cardioprotective-effects-of-combined-chromium-picolinate-and-atorvastatin-treatment-in-triton-x-100-induced-hyperlipidemia-in-rats-impact-on-some-biochemical-markers
#8
Noha M Shafik, Amal Baalash, Abla M Ebeid
Hyperlipidemia is one of the major risk factors for atherosclerosis and ischemic heart disease. Chromium (Cr) mineral is playing a crucial role in glucose and lipid homeostasis. The aim of this study was to evaluate the protective effects of combined chromium picolinate (CrPic) and atorvastatin treatment against hyperlipidemia-induced cardiac injury. Seventy-five male albino rats were divided into five groups (15 rats each). Hyperlipidemia was induced by intraperitoneal injection of a single dose of Triton X-100 (300 mg/kg body weight (b...
April 13, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28404092/tenofovir-alafenamide-versus-tenofovir-disoproxil-fumarate-for-the-treatment-of-patients-with-hbeag-negative-chronic-hepatitis-b-virus-infection-a-randomised-double-blind-phase-3-non-inferiority-trial
#9
Maria Buti, Edward Gane, Wai Kay Seto, Henry L Y Chan, Wan-Long Chuang, Tatjana Stepanova, Aric-Josun Hui, Young-Suk Lim, Rajiv Mehta, Harry L A Janssen, Subrat K Acharya, John F Flaherty, Benedetta Massetto, Andrea L Cathcart, Kyungpil Kim, Anuj Gaggar, G Mani Subramanian, John G McHutchison, Calvin Q Pan, Maurizia Brunetto, Namiki Izumi, Patrick Marcellin
BACKGROUND: The novel prodrug tenofovir alafenamide delivers the nucleotide reverse transcriptase inhibitor tenofovir to target cells more efficiently at a lower dose than tenofovir disoproxil fumarate, thereby reducing systemic exposure. We compared the efficacy and safety of the two drugs in patients with HBeAg-negative chronic hepatitis B virus (HBV) infection in a non-inferiority study. METHODS: In this ongoing randomised, double-blind, phase 3, non-inferiority study in 105 centres in 17 countries, patients with HBeAg-negative chronic HBV were randomly assigned (2:1) by a computer-generated allocation sequence (block size six), stratified by plasma HBV DNA concentration and previous treatment status, to receive once-daily oral doses of tenofovir alafenamide 25 mg or tenofovir disoproxil fumarate 300 mg, each with matching placebo...
November 2016: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28402171/tethered-bone-morphogenetic-protein-2-onto-sulfonated-polyrotaxane-based-surfaces-promotes-osteogenic-differentiation-of-mc3t3-e1-cells
#10
Yoshinori Arisaka, Nobuhiko Yui
Sulfonated-polyrotaxane (PRX)-coated surfaces with tethered bone morphogenetic protein-2 (BMP-2) were designed for inducing osteogenic differentiation of MC3T3-E1 cells (preosteoblasts). Sulfonated-PRX triblock copolymers composed of sulfopropyl ether-modified α-cyclodextrins (α-CDs) threaded onto a poly(ethylene glycol) (PEG) chain as a PRX segment and poly(benzyl methacrylate) (PBzMA) at both terminals of the PEG as anchoring segments were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization...
April 20, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28394825/body-composition-assessment-in-the-prediction-of-osteoporotic-fractures
#11
Mélany Hars, Andrea Trombetti
PURPOSE OF REVIEW: To give an overview of recent research findings and insights on the role of body composition assessment in fracture risk prediction. RECENT FINDINGS: While there is to date little doubt that bone mineral density (BMD) is a main pathogenic factor of osteoporotic fractures, recent studies have emphasized the independent contribution of body composition components, especially lean mass, to fracture risk. In this article, we address body composition changes with aging, before to focus on recent studies addressing the contribution of lean and fat mass to fracture risk, together with some hypothesized mechanisms and clinical implications...
April 7, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28377978/long-term-treatment-with-odanacatib-maintains-normal-trabecular-biomechanical-properties-in-ovariectomized-adult-monkeys-as-demonstrated-by-micro-ct-based-finite-element-analysis
#12
Antonio Cabal, Donald S Williams, Richa Y Jayakar, Jingru Zhang, Swanand Sardesai, Le T Duong
The cathepsin K inhibitor odanacatib (ODN) is a potent and reversible inhibitor of osteoclastic resorption activity. This drug is currently under development for the treatment of postmenopausal osteoporosis. Previously, we described data on the treatment efficacy of ODN in a preclinical estrogen-deficient model of an ovariectomized (OVX) rhesus monkey using HR-pQCT based finite element analysis (FEA) in vivo estimates of bone strength on the distal radius. To support the bone safety profile of ODN, we report ex vivo data on the apparent and hard tissue biomechanical properties of the trabecular bone of vertebrae of animals after 20 months of dosing in three treatment groups: Vehicle (VEH), ODN (2 mg/kg/day), and ALN (30 μg/kg/week)...
June 2017: Bone Reports
https://www.readbyqxmd.com/read/28373695/catalyzed-synthesis-of-zinc-clays-by-prebiotic-central-metabolites
#13
Ruixin Zhou, Kaustuv Basu, Hyman Hartman, Christopher J Matocha, S Kelly Sears, Hojatollah Vali, Marcelo I Guzman
How primordial metabolic networks such as the reverse tricarboxylic acid (rTCA) cycle and clay mineral catalysts coevolved remains a mystery in the puzzle to understand the origin of life. While prebiotic reactions from the rTCA cycle were accomplished via photochemistry on semiconductor minerals, the synthesis of clays was demonstrated at low temperature and ambient pressure catalyzed by oxalate. Herein, the crystallization of clay minerals is catalyzed by succinate, an example of a photoproduced intermediate from central metabolism...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28369239/coronary-artery-doppler-patterns-are-associated-with-clinical-outcomes-post-arterial-switch-operation-for-transposition-of-the-great-arteries
#14
Lynne E Nield, Andreea Dragulescu, Christine MacColl, Cedric Manlhiot, Henrik Brun, Brian W McCrindle, Bart Kuipers, Christopher A Caldarone, Steven E S Miner, Luc Mertens
Aims: Transposition of the great arteries (TGA) is generally repaired using the arterial switch operation (ASO) involving coronary transfer. The objective of this prospective study was to determine whether specific coronary Doppler patterns intra-operatively predicted adverse early myocardial events. Methods and results: Patients < 3 months old with TGA undergoing the ASO were eligible. All patients (when feasible) underwent an intra-operative transoesophageal echo (TEE) plus an epicardial echo and had pre-op, early post-op, pre-discharge and follow-up functional echocardiograms...
March 28, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28365680/pro-inflammatory-cytokine-tnf-%C3%AE-attenuates-bmp9-induced-osteo-odontoblastic-differentiation-of-the-stem-cells-of-dental-apical-papilla-scaps
#15
Feilong Wang, Ying Jiang, Xia Huang, Qiao Liu, Yan Zhang, Wenping Luo, Fugui Zhang, Pengfei Zhou, Juhong Lin, Hongmei Zhang
BACKGROUND/AIMS: Periapical periodontitis is a common oral disease caused by bacterial invasion of the tooth pulp, which usually leads to local release of pro-inflammatory cytokines and osteolytic lesion. This study is intended to examine the effect of TNF-α on BMP9-induced osteogenic differentiation of the stem cells of dental apical papilla (SCAPs). METHODS: Rat model of periapical periodontitis was established. TNF-α expression was assessed. Osteogenic markers and ectopic bone formation in iSCAPs were analyzed upon BMP9 and TNF-α treatment...
March 31, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28364342/in-vitro-proliferation-and-osteogenic-differentiation-of-endometrial-stem-cells-and-dental-pulp-stem-cells
#16
Fahimeh Sadat Tabatabaei, Maryam Torshabi
Stem-cell-based therapies were introduced aiming to overcome the limitations of the existing procedures for regeneration of mineralized tissues. Stem cells isolated from the endometrial tissue and dental pulp have the capacity to differentiate into various functional cells including osteoblasts. However, studies comparing their ability to regenerate mineralized tissue are lacking. The purpose of this study was to compare the proliferation and osteogenic differentiation potential of endometrial stem cells (EnSCs) and dental pulp stem cells (DPSCs) using in vitro cell culture technique...
March 31, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28363169/glucocorticoid-induced-leucine-zipper-may-play-an-important-role-in-icariin-by-suppressing-osteogenesis-inhibition-induced-by-glucocorticoids-in-osteoblasts
#17
Zhong Lin, Zheng Li Jiang, Li Hua Chen, Yuan Sun, Sai Zhen Chen, Peng Zhou, Ai Xiao Xia, Hui Jin, Yan Wu Zhu, Dan Yang Chen
BACKGROUND AND PURPOSE: Icariin is a potent stimulator of osteogenic differentiation; however, the mechanism underlying its osteogenic effect remains unclear. The osteogenic effect of icariin is related to the upstream glucocorticoid-induced leucine zipper (GILZ) signaling pathway, and antagonism with dexamethasone-induced osteoblast inhibition was noted. METHODS: MC3T3-E1 cells were cultured in induced medium treated with icariin with or without dexamethasone. After short interfering RNA (siRNA) were used to silence GILZ expression, the degree of mineralization, proliferation, and GILZ expression as well as the levels of osteogenic (OPG, RANKL, ALP, OC and RUNX2) markers were tested...
March 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28356291/slowly-cycling-rho-kinase-dependent-actomyosin-crossbridge-slippage-explains-intrinsic-high-compliance-of-detrusor-smooth-muscle
#18
Christopher J Neal, Jia Bao Lin, Tanner Hurley, Amy S Miner, John E Speich, Adam P Klausner, Paul H Ratz
Biological soft tissues are viscoelastic because they display time-independent pseudo-elasticity and time-dependent viscosity. Upon an imposed ramp increase then decrease in strain, the resultant stress changes, termed loading and unloading respectively, produce nonlinear stress-strain curves and a reversible reduction in the stress-strain work area that identifies viscosity. However, there is evidence that bladder may also display plasticity; an increase in strain that is unrecoverable unless work is done by the muscle...
March 29, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28343926/cobalt-chloride-enhances-the-stemness-of-human-dental-pulp-cells
#19
Kantaporn Laksana, Sireerat Sooampon, Prasit Pavasant, Wannakorn Sriarj
INTRODUCTION: Hypoxia is a factor in controlling stem cell stemness. We investigated if cobalt chloride (CoCl2), a chemical agent that mimics hypoxia in vitro, affected human dental pulp cell (hDPC) stemness by examining cell proliferation, stem cell marker expression, and osteogenic differentiation. METHODS: hDPCs were cultured with or without 25 or 50 μmol/L CoCl2. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used to determine cell proliferation...
March 23, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28343085/guava-fruit-extract-and-its-triterpene-constituents-have-osteoanabolic-effect-stimulation-of-osteoblast-differentiation-by-activation-of-mitochondrial-respiration-via-the-wnt-%C3%AE-catenin-signaling
#20
Konica Porwal, Subhashis Pal, Kapil Dev, Shyamsundar Pal China, Yogesh Kumar, Chandan Singh, Tarun Barbhuyan, Neeraj Sinha, Sabyasachi Sanyal, Arun Kumar Trivedi, Rakesh Maurya, Naibedya Chattopadhyay
The aim of this study was to evaluate the skeletal effect of guava triterpene-enriched extract (GE) in rats and identify osteogenic compounds thereof, and determine their modes of action. In growing female rats, GE at 250 mg/kg dose increased parameters of peak bone mass including femur length, bone mineral density (BMD) and biomechanical strength, suggesting that GE promoted modeling-directed bone growth. GE also stimulated bone regeneration at the site of bone injury. In adult osteopenic rats (osteopenia induced by ovariectomy, OVX) GE completely restored the lost bones at both axial and appendicular sites, suggesting a strong osteoanabolic effect...
March 8, 2017: Journal of Nutritional Biochemistry
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