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https://www.readbyqxmd.com/read/28926282/bacterial-and-archaeal-lipids-recovered-from-subsurface-evaporites-of-dalangtan-playa-on-the-tibetan-plateau-and-their-astrobiological-implications
#1
Ziye Cheng, Long Xiao, Hongmei Wang, Huan Yang, Jingjing Li, Ting Huang, Yi Xu, Nina Ma
Qaidam Basin (Tibetan Plateau) is considered an applicable analogue to Mars with regard to sustained extreme aridity and abundant evaporites. To investigate the possibility of the preservation of microbial lipids under these Mars analog conditions, we conducted a mineralogical and organic geochemistry study on samples collected from two Quaternary sections in Dalangtan Playa, northwestern Qaidam Basin, which will enhance our understanding of the potential preservation of molecular biomarkers on Mars. Two sedimentary units were identified along two profiles: one salt unit characterized by a predominance of gypsum and halite, and one detrital unit with a decrease of gypsum and halite and enrichment in siliciclastic minerals...
September 19, 2017: Astrobiology
https://www.readbyqxmd.com/read/28921830/trends-application-and-future-prospectives-of-microbial-carbonic-anhydrase-mediated-carbonation-process-for-ccus
#2
REVIEW
Chintan Bhagat, Pravin Dudhagara, Shantilal Tank
Growing industrialisation and desire for better economy of countries accelerated the emission of greenhouse gasses, more than the buffering capacity of earth atmosphere. Among, various Green House Gasses (GHGs), CO2 occupies the first position in anthroposphere and has detrimental effects on the ecosystem. For decarbonization, several non-biological methods of carbon capture, utilisation, and storage (CCUS) are in use from last few decades, but they are suffering from narrow applicability. Recently, CO2 emission and its disposal related problem encourage for implementation of bioprocessing to achieve zero waste economy for a sustainable environment...
September 18, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28921615/plasticizer-di-2-ethylhexyl-phthalate-interferes-with-osteoblastogenesis-and-adipogenesis-in-a-mouse-model
#3
Chen-Yuan Chiu, Shih-Chun Sun, Chih-Kang Chiang, Ching-Chia Wang, Ding-Cheng Chan, Huang-Jen Chen, Shing-Hwa Liu, Rong-Sen Yang
Plasticizer di(2-ethylhexyl)phthalate (DEHP) can leach from medical devices such as blood storage bags and the tubing. Recently, epidemiological studies showed that phthalate metabolites levels in the urine are associated with low bone mineral density (BMD) in older women. The detailed effect and mechanism of DEHP on osteoblastogenesis and adipogenesis and bone loss remain to be clarified. Here, we investigated the effect and mechanism of DEHP and its active metabolite mono(2 -ethylhexyl)phthalate (MEHP) on osteoblastogenesis and adipogenesis...
September 16, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28919711/protective-role-of-quercetin-against-manganese-induced-injury-in-the-liver-kidney-and-lung-and-hematological-parameters-in-acute-and-subchronic-rat-models
#4
Entaz Bahar, Geum-Hwa Lee, Kashi Raj Bhattarai, Hwa-Young Lee, Hyun-Kyoung Kim, Mallikarjun Handigund, Min-Kyung Choi, Sun-Young Han, Han-Jung Chae, Hyonok Yoon
Manganese (Mn) is an important mineral element required in trace amounts for development of the human body, while over- or chronic-exposure can cause serious organ toxicity. The current study was designed to evaluate the protective role of quercetin (Qct) against Mn-induced toxicity in the liver, kidney, lung, and hematological parameters in acute and subchronic rat models. Male Sprague Dawley rats were divided into control, Mn (100 mg/kg for acute model and 15 mg/kg for subchronic model), and Mn + Qct (25 and 50 mg/kg) groups in both acute and subchronic models...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28915397/alleviation-of-cadmium-toxicity-in-lemna-minor-by-exogenous-salicylic-acid
#5
Qianqian Lu, Tingting Zhang, Wei Zhang, Chunlei Su, Yaru Yang, Dan Hu, Qinsong Xu
Cadmium (Cd) is a significant environmental pollutant in the aquatic environment. Salicylic acid (SA) is a ubiquitous phenolic compound. The goal of this study was to assess the morphological, physiological and biochemical changes in duckweed (L. minor) upon exposure to 10μM CdCl2, 10μM CdCl2 plus 50μM SA, or 50μM SA for 7 days. Reversing the effects of Cd, SA decreased Cd accumulation in plants, improved accumulation of minerals (Ca, Mg, Fe, B, Mo) absorption, increased endogenous SA concentration, and phenylalanine ammonialyase (PAL) activity...
September 12, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28903553/monitoring-microbial-mineralization-using-reverse-stable-isotope-labelling-analysis-by-mid-infrared-laser-spectroscopy
#6
Xiyang Dong, Maik A Jochmann, Martin Elsner, Armin H Meyer, Leonard E Bäcker, Mona Rahmatullah, Daniel Schunk, Guido Lens, Rainer Udo Meckenstock
Assessing the biodegradation of organic compounds is a frequent question in environmental science. Here, we present a sensitive, inexpensive, and simple approach to monitor microbial mineralization using reverse stable isotope labelling analysis (RIL) of dissolved inorganic carbon (DIC). The medium for the biodegradation assay contains regular organic compounds and (13)C-labelled DIC with (13)C atom fractions (x((13)C)DIC) higher than natural abundance (typically 2-50%). The produced CO2 (x((13)C) ≈ 1.11%) gradually dilutes the initial x((13)C)DIC allowing to quantify microbial mineralization using mass-balance calculations...
September 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28902344/insulin-like-growth-factor-1-promotes-the-proliferation-and-odontoblastic-differentiation-of-human-dental-pulp-cells-under-high-glucose-conditions
#7
Lu Yan, Shangmin Sun, Liu Qu
Insulin-like growth factor-1 (IGF-1) promotes human dental pulp stem cell proliferation and osteogenic differentiation. However, the effects of IGF-1 on the proliferation, apoptosis and odontoblastic differentiation (mineralization) of dental pulp cells (DPCs) under high glucose (GLU) conditions remain unclear. In this study, isolated primary human DPCs were treated with various concentrations of high GLU. Cell proliferation and apoptosis were determined by Cell Counting Kit-8 and Annexin V-FITC/PI assays, respectively...
September 1, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28901385/protective-effect-of-rhizoma-dioscoreae-extract-against-alveolar-bone-loss-in-ovariectomized-rats-via-regulation-of-il-6-stat3-signaling
#8
Zhi-Guo Zhang, Yan-Jing Chen, Li-Hua Xiang, Jing-Hua Pan, Zhen Wang, Gary Guishan Xiao, Da-Hong Ju
The aim of the present study was to assess the effectiveness of Rhizoma Dioscoreae extract (RDE) on preventing rat alveolar bone loss induced by ovariectomy (OVX), and to determine the role of interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling pathway in this effect. Female Wistar rats were subjected to OVX or sham surgery. The rats that had undergone OVX were treated with RDE (RDE group), vehicle (OVX group) or 17β-estradiol subcutaneous injection (E2 group). Subsequently, bone metabolic activity was assessed by analyzing 3-D alveolar bone construction, bone mineral density, as well as the plasma biomarkers of bone turnover...
September 8, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28894789/impact-of-the-mk-vi-skinsuit-on-skin-microbiota-of-terrestrial-volunteers-and-an-international-space-station-bound-astronaut
#9
Richard A Stabler, Helena Rosado, Ronan Doyle, David Negus, Philip A Carvil, Juan G Kristjánsson, David A Green, Rafael Franco-Cendejas, Cadi Davies, Andreas Mogensen, Jonathan Scott, Peter W Taylor
Microgravity induces physiological deconditioning due to the absence of gravity loading, resulting in bone mineral density loss, atrophy of lower limb skeletal and postural muscles, and lengthening of the spine. SkinSuit is a lightweight compression suit designed to provide head-to-foot (axial) loading to counteract spinal elongation during spaceflight. As synthetic garments may impact negatively on the skin microbiome, we used 16S ribosomal RNA (rRNA) gene amplicon procedures to define bacterial skin communities at sebaceous and moist body sites of five healthy male volunteers undergoing SkinSuit evaluation...
2017: NPJ Microgravity
https://www.readbyqxmd.com/read/28894143/3d-calcite-heterostructures-for-dynamic-and-deformable-mineralized-matrices
#10
Jaeseok Yi, Yucai Wang, Yuanwen Jiang, Il Woong Jung, Wenjun Liu, Vincent De Andrade, Ruqing Xu, Ramya Parameswaran, Ivo R Peters, Ralu Divan, Xianghui Xiao, Tao Sun, Youjin Lee, Won Il Park, Bozhi Tian
Scales are rooted in soft tissues, and are regenerated by specialized cells. The realization of dynamic synthetic analogues with inorganic materials has been a significant challenge, because the abiological regeneration sites that could yield deterministic growth behavior are hard to form. Here we overcome this fundamental hurdle by constructing a mutable and deformable array of three-dimensional calcite heterostructures that are partially locked in silicone. Individual calcite crystals exhibit asymmetrical dumbbell shapes and are prepared by a parallel tectonic approach under ambient conditions...
September 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28892768/advanced-oxidation-and-disinfection-processes-for-onsite-net-zero-greywater-reuse-a-review
#11
REVIEW
Lucien W Gassie, James D Englehardt
Net-zero greywater (NZGW) reuse, or nearly closed-loop recycle of greywater for all original uses, can recover both water and its attendant hot-water thermal energy, while avoiding the installation and maintenance of a separate greywater sewer in residential areas. Such a system, if portable, could also provide wash water for remote emergency health care units. However, such greywater reuse engenders human contact with the recycled water, and hence superior treatment. The purpose of this paper is to review processes applicable to the mineralization of organics, including control of oxidative byproducts such as bromate, and maintenance of disinfection consistent with potable reuse guidelines, in NZGW systems...
August 30, 2017: Water Research
https://www.readbyqxmd.com/read/28886763/bioactive-dental-composites-and-bonding-agents-having-remineralizing-and-antibacterial-characteristics
#12
REVIEW
Ke Zhang, Ning Zhang, Michael D Weir, Mark A Reynolds, Yuxing Bai, Hockin H K Xu
Current dental restorative materials are typically inert and replace missing tooth structures. This article reviews efforts in the development of a new generation of bioactive materials designed to not only replace the missing tooth volume but also possess therapeutic functions. Composites and bonding agents with remineralizing and antibacterial characteristics have shown promise in replacing lost minerals, inhibiting recurrent caries, neutralizing acids, repelling proteins, and suppressing biofilms and acid production...
October 2017: Dental Clinics of North America
https://www.readbyqxmd.com/read/28882944/netrin-4-promotes-differentiation-and-migration-of-osteoblasts
#13
Yuichiro Enoki, Tsuyoshi Sato, Shoichiro Kokabu, Naoki Hayashi, Takanori Iwata, Masayuki Yamato, Michihiko Usui, Masahito Matsumoto, Taketo Tomoda, Wataru Ariyoshi, Tatsuji Nishihara, Tetsuya Yoda
BACKGROUND/AIM: While netrin-4 plays a vital role in the vascular system, the role of netrin-1 in osteoblast differentiation is not well understood. In this study we explored whether netrin-4 has functional roles in osteoblasts. MATERIALS AND METHODS: Quantitative reverse-transcriptase polymerase chain reaction (PCR), RNA interference, the generation of plasmids, transfections, measurement of alkaline phosphatase activity, a mineralization assay, a migration assay and a cell proliferation assay were performed...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28857167/tumor-necrosis-factor-alpha-inhibits-osteogenic-differentiation-of-pre-osteoblasts-by-downregulation-of-ephb4-signaling-via-activated-nuclear-factor-kappab-signaling-pathway
#14
L M Wang, N Zhao, J Zhang, Q F Sun, C Z Yang, P S Yang
BACKGROUND AND OBJECTIVE: The majority of experiments show that tumor necrosis factor-alpha (TNF-α) inhibits osteogenic differentiation of mesenchymal stem cells and pre-osteoblasts by activated nuclear factor-kappaB (NF-κB) signaling. However, the underlying mechanisms by which NF-κB signaling inhibits osteogenic differentiation are not fully understood. The aim of the present study was to investigate whether EphB4 signaling inhibition mediates the effects of TNF-α-activated NF-κB signaling on osteogenic differentiation of pre-osteoblasts...
August 31, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28855754/clinical-evaluation-of-mineral-trioxide-aggregate-and-biodentine-as-direct-pulp-capping-agents-in-carious-teeth
#15
Swaroop Hegde, B Sowmya, Sylvia Mathew, Shilpa H Bhandi, Shruthi Nagaraja, K Dinesh
BACKGROUND: Root canal treatment has been a routine treatment option for carious exposure of the dental pulp. In the context of minimally invasive dentistry, direct pulp capping (DPC) procedure with a reliable biomaterial may be considered as an alternative provided the pulp status is favorable. Mineral trioxide aggregate (MTA), a bioactive cement with excellent sealing ability and biocompatibility is capable of regenerating relatively damaged pulp and formation of dentin bridge when used as DPC agent...
March 2017: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/28846614/antimicrobial-properties-of-silver-cations-substituted-to-faujasite-mineral
#16
Roman J Jędrzejczyk, Katarzyna Turnau, Przemysław J Jodłowski, Damian K Chlebda, Tomasz Łojewski, Joanna Łojewska
A goal of our study was to find an alternative to nano-silver-based antimicrobial materials which would contain active silver immobilized in a solid matrix that prevents its migration into the surrounding environment. In this study, we investigated whether silver cations dispersed in an atomic form and trapped in an ion-exchanged zeolite show comparable antimicrobial activity to silver nanoparticles (NPs). The biocidal active material was prepared from the sodium form of faujasite type zeolite in two steps: (1) exchange with silver cations, (2) removal of the external silver oxide NPs by elution with Na₂EDTA solution...
August 27, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28846382/rates-of-co2-mineralization-in-geological-carbon-storage
#17
Shuo Zhang, Donald J DePaolo
Geologic carbon storage (GCS) involves capture and purification of CO2 at industrial emission sources, compression into a supercritical state, and subsequent injection into geologic formations. This process reverses the flow of carbon to the atmosphere with the intention of returning the carbon to long-term geologic storage. Models suggest that most of the injected CO2 will be "trapped" in the subsurface by physical means, but the most risk-free and permanent form of carbon storage is as carbonate minerals (Ca,Mg,Fe)CO3...
August 28, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28844671/transcriptional-profiling-of-human-femoral-mesenchymal-stem-cells-in-osteoporosis-and-its-association-with-adipogenesis
#18
Yong Jun Choi, Insun Song, Yilan Jin, Hyun-Seok Jin, Hyung Min Ji, Seon-Yong Jeong, Ye-Yeon Won, Yoon-Sok Chung
Genetic alterations are major contributing factors in the development of osteoporosis. Osteoblasts and adipocytes share a common origin, mesenchymal stem cells (MSCs), and their genetic determinants might be important in the relationship between osteoporosis and obesity. In the present study, we aimed to isolate differentially expressed genes (DEGs) in osteoporosis and normal controls using human MSCs, and elucidate the common pathways and genes related to osteoporosis and adipogenesis. Human MSCs were obtained from the bone marrow of femurs from postmenopausal women during orthopedic surgeries...
October 20, 2017: Gene
https://www.readbyqxmd.com/read/28843411/the-activin-receptor-is-stimulated-in-the-skeleton-vasculature-heart-and-kidney-during-chronic-kidney-disease
#19
Matthew J Williams, Toshifumi Sugatani, Olga A Agapova, Yifu Fang, Joseph P Gaut, Marie-Claude Faugere, Hartmut H Malluche, Keith A Hruska
We examined activin receptor type IIA (ActRIIA) activation in chronic kidney disease (CKD) by signal analysis and inhibition in mice with Alport syndrome using the ActRIIA ligand trap RAP-011 initiated in 75-day-old Alport mice. At 200 days of age, there was severe CKD and associated Mineral and Bone Disorder (CKD-MBD), consisting of osteodystrophy, vascular calcification, cardiac hypertrophy, hyperphosphatemia, hyperparathyroidism, elevated FGF23, and reduced klotho. The CKD-induced bone resorption and osteoblast dysfunction was reversed, and bone formation was increased by RAP-011...
August 23, 2017: Kidney International
https://www.readbyqxmd.com/read/28842727/effect-of-vitamin-d3-on-bone-turnover-markers-in-critical-illness-post-hoc-analysis-from-the-vitdal-icu-study
#20
V Schwetz, C Schnedl, T Urbanic-Purkart, C Trummer, H P Dimai, A Fahrleitner-Pammer, C Putz-Bankuti, K B Christopher, B Obermayer-Pietsch, T R Pieber, H Dobnig, K Amrein
In this post hoc analysis of the VITdAL-ICU study, an RCT in critically ill adults with 25-hydroxyvitamin D levels ≤20 ng/ml, vitamin D3 did not have a significant effect on β-Crosslaps and osteocalcin. INTRODUCTION: Observational studies have shown accelerated bone loss in ICU survivors. A reversible contributor is vitamin D deficiency. In a post hoc analysis of the VITdAL-ICU study, we evaluated the effect of high-dose vitamin D3 on the bone turnover markers (BTM) β-Crosslaps (CTX) and osteocalcin (OC)...
August 25, 2017: Osteoporosis International
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