keyword
MENU ▼
Read by QxMD icon Read
search

reverse mineralization

keyword
https://www.readbyqxmd.com/read/29770951/requirement-of-tgf%C3%AE-signaling-for-effect-of-fluoride-on-osteoblastic-differentiation
#1
Jingmin Zhang, Ningning Jiang, Haolan Yu, Xiuhua Yu, Fengyang Guo, Zhitao Zhao, Hui Xu
Research focused on transforming growth factor β (TGFβ) signaling in osteoblast is gradually increasing, whereas literature is rare in terms of fluorosis. This work aimed to investigate how TGFβ signaling participated in regulation of the osteoblast by different doses of fluoride treatment. Bone marrow stem cells (BMSCs) were developed into osteoblastic cells and exposed to 1, 4, and 16 mg/L F- with and without 10 ng/mL of TGFβ. Cell viability and differentiation state of osteoblast under different settings were measured by means of cell counting kit and analysis of alkaline phosphatase (ALP) activity as well as formation of mineral nodules...
May 16, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29767241/transcriptome-sequencing-analysis-reveals-the-effect-of-combinative-treatment-with-low%C3%A2-intensity-pulsed-ultrasound-and-magnesium-ions-on-hfob1-19-human-osteoblast-cells
#2
Haiyue Zu, Xueting Yi, Dewei Zhao
Biodegradable magnesium (Mg) materials are considered ideal as osteosynthesis implants. However, clinical application has proven complex. This is primarily associated with the issue of reducing the extent of implant degradation to a range acceptable for the human body, while simultaneously enhancing osteogenesis or osteoinduction. In the present study, a combination of Mg ions and low‑intensity pulsed ultrasound (LIPUS) treatment was applied in hFOB 1.19 human osteoblast cells as a potential strategy to resolve this issue...
May 11, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29762846/neurotrophin-3-improves-fracture-healing-in-rats
#3
X Li, D-C Sun, Y Li, X-Y Wu
OBJECTIVE: This study aimed at investigating the role of Neurotrophin-3 (NT-3) in the bone fracture healing of rats and to provide a reference for clinical treatment. MATERIALS AND METHODS: 40 Sprague-Dawley (SD) rats were randomly divided into control group and NT-3 group. The tibia fracture model was made in NT-3 group, and the tibia bone mineral density (BMD) was measured before and after the surgery. The biomechanics indexes were inspected after the surgery, including elasticity modulus, max load, and bending rigidity...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29754633/morbidity-of-cushing-s-syndrome-and-impact-of-treatment
#4
REVIEW
Susan M Webb, Elena Valassi
Cortisol excess in Cushing's syndrome is associated with metabolic, cardiovascular, and cognitive alterations, only partially reversible after resolution of hypercortisolism. Elevated cardiovascular risk may persist after eucortisolism has been achieved. Fractures and low bone mineral density are also described in Cushing's syndrome in remission. Hypercortisolism may induce irreversible structural and functional changes in the brain, leading to neuropsychiatric disorders in the active phase of the disease, which persist...
June 2018: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/29752083/how-cell-culture-conditions-affect-the-microstructure-and-nanomechanical-properties-of-extracellular-matrix-formed-by-immortalized-human-mesenchymal-stem-cells-an-experimental-and-modelling-study
#5
Pengfei Duan, Ria Toumpaniari, Simon Partridge, Mark A Birch, Paul G Genever, Steve J Bull, Kenneth W Dalgarno, Andrew W McCaskie, Jinju Chen
This paper presents an investigation of how different culture media (i.e. basal and osteogenic media) affect the nanomechanical properties and microstructure of the mineralized matrix produced by the human mesenchymal stem cell line Y201, from both an experimental and theoretical approach. A bone nodule (i.e. mineralized matrix) cultured from basal medium shows a more anisotropic microstructure compared to its counterpart cultured from an osteogenic medium. As confirmed by finite element simulations, this anisotropic microstructure explains the bimodal distribution of the corresponding mechanical properties very well...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29744522/-impact-of-thyroid-diseases-on-bone
#6
REVIEW
E Tsourdi, F Lademann, H Siggelkow
Thyroid hormones are key regulators of skeletal development in childhood and bone homeostasis in adulthood, and thyroid diseases have been associated with increased osteoporotic fractures. Hypothyroidism in children leads to an impaired skeletal maturation and mineralization, but an adequate and timely substitution with thyroid hormones stimulates bone growth. Conversely, hyperthyroidism at a young age accelerates skeletal development, but may also cause short stature because of a premature fusion of the growth plates...
May 9, 2018: Der Internist
https://www.readbyqxmd.com/read/29738286/self-limiting-versus-conventional-caries-removal-a-randomized-clinical-trial
#7
A H Ali, G Koller, F Foschi, M Andiappan, K D Bruce, A Banerjee, F Mannocci
A single-blind randomized controlled clinical trial in patients with deep caries and symptoms of reversible pulpitis compared outcomes from a self-limiting excavation protocol using chemomechanical Carisolv gel/operating microscope (self-limiting) versus selective removal to leathery dentin using rotary burs (control). This was followed by pulp protection with mineral trioxide aggregate (MTA) and restoration with glass ionomer cement and resin composite, all in a single visit. The pulp sensibility and periapical health of teeth were assessed after 12 mo, in addition to the differences in bacterial tissue concentration postexcavation...
May 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29720299/effects-of-denosumab-after-treatment-discontinuation-a-review-of-the-literature
#8
Maryam Iranikhah, Crystal Deas, Pilar Murphy, Maisha Kelly Freeman
OBJECTIVE: To review and summarize studies on the effects of denosumab on bone mineral density following the discontinuation of therapy. DATA SOURCES: A search of PubMed (1966-July 2017) and International Pharmaceutical Abstracts (1970-July 2017) was conducted using the Medical Subject Headings (MeSH) terms denosumab, osteoporosis, and withholding treatment in combination with free term searches including the words drug holiday, discontinue, discontin*, and drug discontinuation...
March 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29706903/high-molecular-weight-polymer-promotes-bone-health-and-prevents-bone-loss-under-salmonella-challenge-in-broiler-chickens
#9
Sandi Raehtz, Billy M Hargis, Vivek A Kuttappan, Rifat Pamukcu, Lisa R Bielke, Laura R McCabe
As a consequence of rapid growth, broiler chickens are more susceptible to infection as well as bone fractures that result in birds being culled. Intestinal infection/inflammation has been demonstrated to promote bone loss in mice and humans. Given this link, we hypothesize that therapeutics that target the gut can benefit bone health. To test this, we infected broiler chickens (7 days old) with Salmonella and treated the birds with or without MDY, a non-absorbable mucus supplement known to benefit intestinal health, from day 1-21 or from day 14-21...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29702282/wedelolactone-inhibits-osteoclastogenesis-but-enhances-osteoblastogenesis-through-altering-different-semaphorins-production
#10
Xue Deng, Li-Na Liang, Di Zhu, Lu-Ping Zheng, Jing-Hua Yu, Xiang-Ling Meng, Yi-Ning Zhao, Xiao-Xin Sun, Tao-Wen Pan, Yan-Qiu Liu
Our previous study showed that wedelolactone, isolated from Ecliptae herba, enhanced osteoblastogenesis but inhibited osteoclastogenesis through Sema3A signaling pathway. This study aims to investigate the role of other semaphorins in wedelolactone-enhanced osteoblastogenesis and -inhibited osteoclastogenesis. Wedelolactone inhibited RANKL-induced Sema4D and Sema7A production, but had no effect on RANKL-reduced Sema6D expression in osteoclastic RAW264.7 cells. In mouse bone marrow mesenchymal stem cells (BMSC), wedelolactone reversed osteogenic medium(OS)-reduced Sema7A expression and OS-enhanced Sema3E mRNA expression, but no effect on OS-reduced Sema3B mRNA expression...
April 24, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29698972/icariin-restores-bone-structure-and-strength-in-a-rat-model-of-chronic-high-dose-alcohol-induced-osteopenia
#11
Jie-Zhou Wu, Peng-Cheng Liu, Run Liu, Ming Cai
BACKGROUND/AIMS: Chronic alcohol abuse is an important risk factor for osteopenia. However, few studies have focused on the efficacy and mechanism of action of icariin on alcohol-induced osteopenia. The aim of this study was to investigate the efficacy and underlying mechanism of action of icariin in the treatment of chronic high-dose alcohol-induced osteopenia in a rat model. METHODS: Thirty-six adult male Sprague-Dawley rats were randomly divided into four groups: sham, alcohol, and low-dose and high-dose icariin groups...
April 23, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29696350/exenatide-preserves-trabecular-bone-microarchitecture-in-experimental-ovariectomized-rat-model
#12
Elmin Eminov, Ismet Hortu, Levent Akman, Oytun Erbas, Altug Yavasoglu, Teksin Cirpan
PURPOSE: The aim of this study is to investigate effects of exenatide (Glucagon-Like Peptide Agonist) replacement on bone mineral density (BMD) and microarchitecture in a surgical menopause-induced osteoporosis model in rats. METHODS: In this study, 24 female Sprague-Dawley albino mature rats were used. Rats were assigned either to the group ovariectomized administered exenatide or to the control group. Bone Mineral Density (BMD), plasma cytokine levels and histomorphometric analysis were measured...
April 25, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29694685/effects-of-24-months-of-treatment-with-romosozumab-followed-by-12-months-of-denosumab-or-placebo-in-postmenopausal-women-with-low-bone-mineral-density-a-randomized-double-blind-phase-2-parallel-group-study
#13
Michael R McClung, Jacques P Brown, Adolfo Diez-Perez, Heinrich Resch, John Caminis, Paul Meisner, Michael A Bolognese, Stefan Goemaere, Henry G Bone, Jose R Zanchetta, Judy Maddox, Sarah Bray, Andreas Grauer
Over 12 months, romosozumab increased bone formation and decreased bone resorption, resulting in increased BMD in postmenopausal women with low BMD (NCT00896532). Herein we report the study extension evaluating 24 months treatment with romosozumab, discontinuation of romosozumab, alendronate followed by romosozumab, and romosozumab followed by denosumab. Postmenopausal women age 55-85 years with a lumbar spine (LS), total hip (TH), or femoral neck T-score ≤-2.0 and ≥-3.5 were enrolled and randomly assigned to placebo, one of five romosozumab regimens (70mg, 140mg, 210mg monthly [QM]; 140mg Q3M; 210mg Q3M) for 24 months, or open-label alendronate for 12 months followed by romosozumab 140mg QM for 12 months...
April 25, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29691303/therapy-of-endocrine-disease-denosumab-versus-bisphosphonates-for-the-treatment-of-postmenopausal-osteoporosis
#14
Athanasios D Anastasilakis, Stergios A Polyzos, Polyzois Makras
The most widely used medications for the treatment of osteoporosis are currently bisphosphonates and denosumab. Both are antiresorptives, thus targeting the osteoclast and inhibiting bone resorption. Denosumab achieves greater suppression of bone turnover and greater increases of bone mineral density (BMD) at all skeletal sites, both in naïve and pre-treated patients. No superiority on fracture risk reduction has been documented so far. In long-term administration, bisphosphonates reach a plateau in BMD response after 2-3 years, especially at the hip, while BMD increases progressively for as long as denosumab is administered...
April 24, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29685658/novel-founder-intronic-variant-in-slc39a14-in-two-families-causing-manganism-and-potential-treatment-strategies
#15
Lance H Rodan, Marissa Hauptman, Alissa M D'Gama, Anita E Qualls, Siqi Cao, Karin Tuschl, Fatma Al-Jasmi, Jozef Hertecant, Susan J Hayflick, Marianne Wessling-Resnick, Edward T Yang, Gerard T Berry, Andrea Gropman, Alan D Woolf, Pankaj B Agrawal
Congenital disorders of manganese metabolism are rare occurrences in children, and medical management of these disorders is complex and challenging. Homozygous exonic mutations in the manganese transporter SLC39A14 have recently been associated with a pediatric-onset neurodegenerative disorder characterized by brain manganese accumulation and clinical signs of manganese neurotoxicity, including parkinsonism-dystonia. We performed whole exome sequencing on DNA samples from two unrelated female children from the United Arab Emirates with progressive movement disorder and brain mineralization, identified a novel homozygous intronic mutation in SLC39A14 in both children, and demonstrated that the mutation leads to aberrant splicing...
April 6, 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29677546/bacitracin-promotes-osteogenic-differentiation-of-human-bone-marrow-mesenchymal-stem-cells-by-stimulating-the-bone-morphogenetic-protein-2-smad-axis
#16
Hui Li, Bin'en Nie, Zhe Du, Shutao Zhang, Teng Long, Bing Yue
Bacitracin, a widely used metallopeptide antibiotic, has been reported to be locally used in treating wounds without systemic adverse reactions. Our preliminary study showed that bacitracin might enhance the osteogenic differentiation of human bone marrow mesenchymal stem cells (HBMSCs). The present study investigated whether bacitracin affects the osteogenic differentiation of HBMSCs and the molecular mechanisms involved. The proliferation of HBMSCs in the presence of bacitracin was examined using a cell counting kit-8 (CCK-8) assay...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29676820/oxygen-evolution-catalysis-with-m%C3%A3-ssbauerite-a-trivalent-iron-only-layered-double-hydroxide
#17
Michael Ertl, Corina Andronescu, Jonathon Moir, Mirijam Zobel, Friedrich E Wagner, Stefan Barwe, Geoffrey Ozin, Wolfgang Schuhmann, Josef Breu
Mössbauerite is investigated for the first time as an "iron only" mineral for the electrocatalytic oxygen evolution reaction in alkaline media. The synthesis proceeds via intermediate mixed-valence green rust that is rapidly oxidized in situ while conserving the layered double hydroxide structure. The material catalyzes the oxygen evolution reaction on a glassy carbon electrode with a current density of 10 mA cm-2 at 1.63 V versus the reversible hydrogen electrode. Stability measurements as well as post-electrolysis characterization are presented...
April 20, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29674593/unexpected-reversal-of-c-3-versus-c-4-grass-response-to-elevated-co-2-during-a-20-year-field-experiment
#18
Peter B Reich, Sarah E Hobbie, Tali D Lee, Melissa A Pastore
Theory predicts and evidence shows that plant species that use the C4 photosynthetic pathway (C4 species) are less responsive to elevated carbon dioxide ( e CO2 ) than species that use only the C3 pathway (C3 species). We document a reversal from this expected C3 -C4 contrast. Over the first 12 years of a 20-year free-air CO2 enrichment experiment with 88 C3 or C4 grassland plots, we found that biomass was markedly enhanced at e CO2 relative to ambient CO2 in C3 but not C4 plots, as expected. During the subsequent 8 years, the pattern reversed: Biomass was markedly enhanced at e CO2 relative to ambient CO2 in C4 but not C3 plots...
April 20, 2018: Science
https://www.readbyqxmd.com/read/29674059/a-novel-amperometric-enzyme-inhibition-biosensor-based-on-xanthine-oxidase-immobilised-onto-glassy-carbon-electrodes-for-bisphenol-a-determination
#19
Najib Ben Messaoud, Mariana Emilia Ghica, Cherif Dridi, Mounir Ben Ali, Christopher M A Brett
A novel and simple biosensor for the determination of bisphenol A (BPA) based on xanthine oxidase (XOD) enzymatic inhibition has been developed. The biosensor was prepared from xanthine oxidase immobilised by crosslinking with glutaraldehyde, with hypoxanthine as enzyme substrate, and was successfully applied to the determination of BPA using fixed potential amperometry. Biosensor performance was optimised with respect to the applied potential, influence of pH of the electrolyte solution, XOD loading and the substrate concentration...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29673685/comparison-of-efficacy-of-dental-varnish-containing-fluoride-either-with-cpp-acp-or-bioglass-on-root-caries-ex-vivo-study
#20
A Sleibi, A R Tappuni, Graham R Davis, P Anderson, A Baysan
OBJECTIVES: To compare the efficacy of fluoride varnishes either casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) or bioglass particles on the severity index of root caries. METHODS: Visual-tactile assessments including lesion hardness was carried out to categorise the severity index of 80 extracted teeth with primary root caries. These teeth were randomly divided into four groups; CPP-ACP and fluoride, bioglass and fluoride, fluoride only, and no treatment...
April 16, 2018: Journal of Dentistry
keyword
keyword
110581
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"