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Hypogonadism masculin

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https://www.readbyqxmd.com/read/27768007/the-effectiveness-of-zinc-supplementation-in-men-with-isolated-hypogonadotropic-hypogonadism
#1
Yan-Ling Liu, Man-Na Zhang, Guo-Yu Tong, Shou-Yue Sun, Yan-Hua Zhu, Ying Cao, Jie Zhang, Hong Huang, Ben Niu, Hong Li, Qing-Hua Guo, Yan Gao, Da-Long Zhu, Xiao-Ying Li
A multicenter, open-label, randomized, controlled superiority trial with 18 months of follow-up was conducted to investigate whether oral zinc supplementation could further promote spermatogenesis in males with isolated hypogonadotropic hypogonadism (IHH) receiving sequential purified urinary follicular-stimulating hormone/human chorionic gonadotropin (uFSH/hCG) replacement. Sixty-seven Chinese male IHH patients were recruited from the Departments of Endocrinology in eight tertiary hospitals and randomly allocated into the sequential uFSH/hCG group (Group A, n = 34) or the sequential uFSH plus zinc supplementation group (Group B, n = 33)...
October 21, 2016: Asian Journal of Andrology
https://www.readbyqxmd.com/read/27453663/operative-considerations-for-late-presenting-persistent-m%C3%A3-llerian-duct-syndrome
#2
Jacob T Ark, Kelvin A Moses
Persistent Müllerian duct syndrome (PMDS) is a condition in which a 46, XY male displays masculine external genitalia, but internally retains developed Müllerian duct structures (uterus, fallopian tubes, and upper two-thirds vagina). Thoughtful operative consideration is needed to maximize the therapeutic benefit while minimizing the risk of hypogonadism, infertility, and erectile dysfunction. We report a 53-year-old male with a pelvic mass incidentally discovered on routine ultrasound, intra-operatively discovered to be PMDS...
July 2016: Urology Annals
https://www.readbyqxmd.com/read/27079813/cell-interactions-and-genetic-regulation-that-contribute-to-testicular-leydig-cell-development-and-differentiation
#3
REVIEW
Luc J Martin
Leydig cells, located within the interstitial compartment of the testis, are major contributors of androgen synthesis and secretion, which play an important role in testis development, normal masculinization, maintenance of spermatogenesis, and general male fertility. Accordingly, dysfunction of Leydig cells may lead to various male reproductive maladies, including primary hypogonadism, cryptorchidism, and hypospadias. A better understanding of how cell interactions and gene regulation contribute to testicular Leydig cell development and differentiation may therefore help limit the incidence of such male reproductive pathologies...
June 2016: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/26945370/efficacy-and-outcome-predictors-of-gonadotropin-treatment-for-male-congenital-hypogonadotropic-hypogonadism-a-retrospective-study-of-223-patients
#4
Zhaoxiang Liu, Jangfeng Mao, Xueyan Wu, Hongli Xu, Xi Wang, Bingkun Huang, Junjie Zheng, Min Nie, Hongbing Zhang
Gonadotropin induces masculinization and spermatogenesis in men with congenital hypogonadotropic hypogonadism (CHH). However, large cohort studies for the efficacy and reliable predictors of this therapy need to be conducted. The aim of this study was to investigate the efficacy of gonadotropin treatment in a large cohort of male CHH patients and analyze putative predictors for successful spermatogenesis. This retrospective study included 223 CHH azoospermic patients without puberty development treated between 2005 and 2014...
March 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26246498/a-new-variant-in-signal-peptide-of-the-human-luteinizing-hormone-receptor-lhcgr-affects-receptor-biogenesis-causing-leydig-cell-hypoplasia
#5
Valeria Vezzoli, Paolo Duminuco, Alessandra Vottero, Gunnar Kleinau, Ralf Schülein, Roberta Minari, Ivan Bassi, Sergio Bernasconi, Luca Persani, Marco Bonomi
The human luteinizing hormone/chorionic gonadotropin receptor (LHCGR) plays a fundamental role in male and female reproduction. In males, loss-of-function mutations in LHCGR have been associated with distinct degrees of impairment in pre- and postnatal testosterone secretion resulting in a variable phenotypic spectrum, classified as Leydig cell hypoplasia (LCH) type 1 (complete LH resistance and disorder of sex differentiation) and type 2 (partial LH resistance with impaired masculinization and fertility). Here, we report the case of an adolescent who came to the pediatric endocrinologist at the age of 12 years old for micropenis and cryptorchidism...
November 1, 2015: Human Molecular Genetics
https://www.readbyqxmd.com/read/26078661/mini-puberty-and-its-interpretation
#6
REVIEW
Selim Kurtoğlu, Osman Baştuğ
Gonadotropins which are high in the middle of the fetal life are measured to be considerably low in the cord blood and estrogen is found to be high in the cord blood. Gonodotropins are supressed by estrogen. After delivery, the hypothalamo-pituitary-gonadal axis is activated when estrogen is eliminated and a hormone profile which reaches pubertal levels is established. These changes are called mini puberty. In boys, long-term testicular functions and sperm production are regulated with mini puberty and mini puberty contributes to masculinization of the brain...
September 2014: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/25825944/sequential-versus-continual-purified-urinary-fsh-hcg-in-men-with-idiopathic-hypogonadotropic-hypogonadism
#7
RANDOMIZED CONTROLLED TRIAL
Manna Zhang, Guoyu Tong, Yanling Liu, Yiming Mu, Jianping Weng, Yaoming Xue, Zuojie Luo, Yuanming Xue, Lixin Shi, Xueyan Wu, Shouyue Sun, Yanhua Zhu, Ying Cao, Jie Zhang, Hong Huang, Ben Niu, Hong Li, Qinghua Guo, Yan Gao, Zhibin Li, Guang Ning, Dalong Zhu, Xiaoying Li
CONTEXT: Gonadotropin therapy using a human chorionic gonadotropin (hCG) and FSH preparation is an effective regimen in inducing masculinization and spermatogenesis in men with idiopathic hypogonadotropic hypogonadism (IHH). However, the high cost of medication and frequent injections affect compliance. OBJECTIVE: The aim of this study was to determine the efficacy of sequential use of highly purified urinary FSH (uFSH)/hCG in men with IHH. DESIGN AND SETTING: A randomized, open-label, prospective, controlled noninferiority trial with an 18-month follow-up was conducted in 9 tertiary hospitals...
June 2015: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/24407186/the-role-of-hypogonadism-in-klinefelter-syndrome
#8
REVIEW
Christian Høst, Anne Skakkebæk, Kristian A Groth, Anders Bojesen
Klinefelter syndrome (KS) (47, XXY) is the most abundant sex-chromosome disorder, and is a common cause of infertility and hypogonadism in men. Most men with KS go through life without knowing the diagnosis, as only 25% are diagnosed and only a few of these before puberty. Apart from hypogonadism and azoospermia, most men with KS suffer from some degree of learning disability and may have various kinds of psychiatric problems. The effects of long-term hypogonadism may be diffi cult to discern from the gene dose effect of the extra X-chromosome...
March 2014: Asian Journal of Andrology
https://www.readbyqxmd.com/read/23287486/-issues-inherent-to-the-management-of-disorders-of-sex-development-in-point-g-hospital
#9
M L Diakité, J G Berthé H, A Timbely, M Diallo, M Maiga, A Diakité, M Diallo, K Ouattara, A Faure
Abnormal sexual development causes unconformity between gender identity and gender role. In countries with low socio-economic level, the optimal management is difficult. The aim of this study was to evaluate the frequency, the genital anatomy appearance, the diagnostic and the surgical management of disorders of sex development (DSD) discovered during the adolescence. Between January 2005 and November 2006 (23 months), five patients with abnormal sexual development were identified in Point G Hospital. First-line testing included biology measurement and imaging...
January 2013: Progrès en Urologie
https://www.readbyqxmd.com/read/22967848/basic-consensus-document-on-late-onset-hypogonadism
#10
Antonio Becerra Fernández, Luis Enríquez Acosta
One of the most important elements in men's live is the ability to engage in normal sexual activity; loss of this activity has always been considered especially important. The relationship between sexual activity, as well as other masculine characteristics, and the testicles has been well known since ancient times and has been related to the slow decrease in testosterone secretion with advanced age. Male hypogonadism is one of the most frequent and under-diagnosed endocrine diseases. Several terms have been proposed to refer to clinical situations caused by the age-related decline in male gonadal function; currently, the most widely accepted term is late-onset hypogonadism (LOH)...
January 2008: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
https://www.readbyqxmd.com/read/22737954/-t-stands-for-testosterone-do-you-have-enough-of-it
#11
Jean-Yves Nau
No abstract text is available yet for this article.
May 30, 2012: Revue Médicale Suisse
https://www.readbyqxmd.com/read/22247861/male-hypogonadism-symptoms-and-treatment
#12
Peeyush Kumar, Nitish Kumar, Devendra Singh Thakur, Ajay Patidar
Male hypogonadism is a condition in which the body does not produce enough of the testosterone hormone; the hormone that plays a key role in masculine growth and development during puberty. There is a clear need to increase the awareness of hypogonadism throughout the medical profession, especially in primary care physicians who are usually the first port of call for the patient. Hypogonadism can significantly reduce the quality of life and has resulted in the loss of livelihood and separation of couples, leading to divorce...
July 2010: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/20068010/disruption-of-the-single-copy-gonadotropin-releasing-hormone-receptor-in-mice-by-gene-trap-severe-reduction-of-reproductive-organs-and-functions-in-developing-and-adult-mice
#13
Sheng Wu, Michael D Wilson, Ellen R Busby, Emma R Isaac, Nancy M Sherwood
Mutations in the GnRH receptor gene (GNRHR) can result in hypogonadotropic hypogonadism in humans. Unlike most mammals, mice lack a second form of GnRH (GnRH2) and a type 2 GnRH receptor. To determine whether the GnRH receptor is critical at all stages of reproduction and whether this receptor has additional physiological functions in developing and adult mice, we have generated mice from an embryonic stem cell line containing a retroviral vector with multiple stop codons inserted into intron 1 of the Gnrhr gene...
March 2010: Endocrinology
https://www.readbyqxmd.com/read/19852429/the-clinical-effects-of-isochromosome-xq-in-klinefelter-syndrome-report-of-a-case-and-review-of-literature
#14
REVIEW
O Demirhan, A Pazarbaşi, N Tanriverdi, A Aridoğan, D Karahan
We describe a male with a variant Klinefelter syndrome (KS), and trisomy Xq resulting from an isochromosome Xq [47,Xi(Xq)Y]. He had many characteristics of classical KS: bilateral atrophic testes and microcalcifications, normal masculinization, azoospermia, hypergonadotropic hypogonadism, elevated FSH and LH, normal intelligence and normal androgenization, but his stature was not increased. Ultrasonographic evaluation also revealed parenchymal alterations secondary to previous epididymo-orchitis. After initial evaluation the patient underwent incisional biopsy of testes which showed tubular hyalinisation, Leydig cell hyperplasia and Certoli cell syndrome...
2009: Genetic Counseling
https://www.readbyqxmd.com/read/19493294/hysterical-traits-are-not-from-the-uterus-but-from-the-testis-a-study-in-men-with-sexual-dysfunction
#15
Elisa Bandini, Giovanni Corona, Valdo Ricca, Alessandra D Fisher, Francesco Lotti, Alessandra Sforza, Carlo Faravelli, Gianni Forti, Edoardo Mannucci, Mario Maggi
INTRODUCTION: The relationship between testosterone (T) and psychopathology in subjects with sexual dysfunction has not been completely clarified. AIM: To evaluate the association between T levels and different psychopathological symptoms and traits in men seeking treatment for sexual dysfunction. METHODS: A consecutive series of 2,042 heterosexual male patients (mean age 51.8 +/- 13) consulting an outpatient clinic for sexual dysfunction was retrospectively studied...
August 2009: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/19205451/infertility-in-a-new-46-xx-male-with-positive-sry-confirmed-by-fluorescence-in-situ-hybridization-a-case-report
#16
C E Pepene, I Coman, D Mihu, M Militaru, I Duncea
The 46, XX male syndrome (de la Chapelle syndrome or 46, XX testicular disorder of sex development) is a rare form of sex reversal with complex mechanisms leading to a large spectrum of clinical manifestations ranging from ambiguous genitalia in the newborn to normal male phenotype. Therefore, diagnosis is established either pre- or early postnatal, or in adult life due to male infertility. In some cases, subtle clinical signs during childhood and puberty may be overlooked. A 28-year-old married man presented with azoospermia without erectile dysfunction...
2008: Clinical and Experimental Obstetrics & Gynecology
https://www.readbyqxmd.com/read/18414071/46-xx-man-with-sry-gene-translocation-cytogenetic-characteristics-clinical-features-and-management
#17
Ali A Rizvi
This report describes a well-masculinized 33-year-old man with infertility and primary hypogonadism in whom chromosomal evaluation revealed a 46, XX karyotype. This syndrome is a rare but important cause of hypergonadotropic hypogonadism in which the diagnosis can be delayed or missed. A review of the cytogenetic basis and clinical features is presented to raise awareness of this entity among clinicians and to emphasize the importance of appropriate laboratory testing when indicated.
April 2008: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/17983170/-importance-of-klinefelter-syndrome-in-the-pathogenesis-of-male-infertility
#18
Carmen-Elena Pralea, Gr Mihalache
UNLABELLED: Klinefelter syndrome, the most knowning hipergonadotrophic hypogonadism, is associated typically with two X chromosomes and one Y chromosome (47,XXY. The signs and symptoms of these conditions typically become more severe as the number of X chromosomes increases. AIM: To preveal the role of Klinefelter syndrome in pathogenesis of male infertility. MATERIAL AND METHODS: The study included 20 men hospitalized and treated in the Endocrinology Clinic, Iaşi...
April 2007: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
https://www.readbyqxmd.com/read/17484401/complete-genital-prosthetization-in-patients-treated-with-bilateral-orchiectomy-for-metachronous-testicular-cancer
#19
Alfio Giuberti, Vittorio Manganini, Stefano Carlo Maria Picozzi, Paolo Viganò, Guido Raffaele Strada
UNLABELLED: Testicular malignant tumours represent 1% of neoplasms. The probability of developing a contralateral tumour is between 3% and 7%. We report two cases of complete genital prosthetization in two patients treated with bilateral orchiectomy for metachronous testicular cancer. In our knowledge no previous case is reported in literature. CASE REPORTS: A 46-year-old patient and a 49-year-old patient underwent bilateral radical orchiectomy for metachronous cancers of the testis...
March 2007: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/17415352/klinefelter-syndrome-in-clinical-practice
#20
REVIEW
Anders Bojesen, Claus H Gravholt
Klinefelter syndrome is the most common sex-chromosome disorder; it affects approximately one in every 660 men. This syndrome is characterized by the presence of one or more extra X chromosomes, and the karyotype 47,XXY is the most prevalent type. The 'prototypic' man with Klinefelter syndrome has traditionally been described as tall, with narrow shoulders, broad hips, sparse body hair, gynecomastia, small testicles, androgen deficiency, azoospermia and decreased verbal intelligence. A less distinct phenotype has, however, been described...
April 2007: Nature Clinical Practice. Urology
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