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REVIEW
Pedro H Imenez Silva, Marion Pepin, Andreja Figurek, Eugenio Gutiérrez-Jiménez, Mickaël Bobot, Anna Iervolino, Francesco Mattace-Raso, Ewout J Hoorn, Matthew A Bailey, Lucie Hénaut, Rikke Nielsen, Sebastian Frische, Francesco Trepiccione, Gaye Hafez, Hande O Altunkaynak, Nicole Endlich, Robert Unwin, Giovambattista Capasso, Vesna Pesic, Ziad Massy, Carsten A Wagner, Connect Consortium
Mild cognitive impairment (MCI) is common in people with chronic kidney disease (CKD) and its prevalence increases with progressive loss of kidney function. MCI is characterized by a decline in cognitive performance greater than expected for an individual age and education level but with minimal impairment of instrumental activities of daily living. Deterioration can affect one or several cognitive domains (attention, memory, executive functions, language, and perceptual motor or social cognition). Given the increasing prevalence of kidney disease, more and more people with CKD will also develop MCI causing an enormous disease burden for these individuals, their relatives and society...
April 18, 2024: American Journal of Physiology. Renal Physiology
#2
JOURNAL ARTICLE
Jen-Ning Tsai, Yun-Hsin Wang, Po-Ju Lin, Chiung-Fang Chang, Chiao-Yin Sun, Yau-Hung Chen
Coriander is a notable medicinal plant known for its diverse properties, including anti-inflammatory, antioxidant, anticancer, analgesic, and anti-diabetic effects. Despite its recognized health benefits, research on its nephroprotective properties is limited. This study aimed to investigate the potential nephroprotective properties of an aqueous extract derived from coriander leaves using an aristolochic acid-intoxicated zebrafish model. To assess kidney abnormalities induced by aristolochic acid (AA), we utilized the transgenic line Tg(wt1b:egfp), which expresses green fluorescent protein (GFP) in the kidney...
April 13, 2024: Environmental Toxicology
#3
JOURNAL ARTICLE
Yake Luo, Shanshan Ma, Jianxun Zhang, Qidong Zhang, Yanhao Zhang, Jian Mao, Hang Yuan, Gangfeng Ouyang, Shusheng Zhang, Wuduo Zhao
Matrix deposition plays a critical role in image quality of matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI). To improve the ionization efficiency and overcome the limitation of traditional matrix deposition methods in the face of difficult-to-sublimate or difficult-to-dissolve matrix, covalent organic frameworks (COFs) named COF-DhaTab was successfully synthesized and firstly used as matrix film. It was fabricated by imprinting of sieved COF-DhaTab powder on the surface of a double-sided adhesive tape...
May 15, 2024: Analytica Chimica Acta
#4
JOURNAL ARTICLE
Hsiu-Chao Chen, Wen-Wei Feng, Gilbert Audira, Kevin Adi Kurnia, San-Ho Hung, Agnes L Castillo, Marri Jmelou M Roldan, Chung-Der Hsiao, Chih-Hsin Hung
Melamine-tainted products have been found in the market and raised issues about food safety. Recent studies done in rodents and humans demonstrated the toxicities of melamine, especially in causing kidney damage and bladder stone formation. However, very few studies assessed its behavior toxicity in organisms, including fish. Therefore, in this study, the researchers aim to determine whether sub-chronic exposure to melamine via oral and systematic administration could induce behavioral abnormality in zebrafish...
April 8, 2024: Neurotoxicology
#5
JOURNAL ARTICLE
Simon Schöfer, Sylvia Laffer, Stefanie Kirchberger, Michael Kothmayer, Renate Löhnert, Elmar E Ebner, Klara Weipoltshammer, Martin Distel, Oliver Pusch, Christian Schöfer
During the aging process, cells can enter cellular senescence, a state in which cells leave the cell cycle but remain viable. This mechanism is thought to protect tissues from propagation of damaged cells and the number of senescent cells has been shown to increase with age. The speed of aging determines the lifespan of a species and it varies significantly in different species. To assess the progress of cellular senescence during lifetime, we performed a comparative longitudinal study using histochemical detection of the senescence-associated beta-galactosidase as senescence marker to map the staining patterns in organs of the long-lived zebrafish and the short-lived turquoise killifish using light- and electron microscopy...
February 29, 2024: European Journal of Histochemistry: EJH
#6
JOURNAL ARTICLE
Lirong Huang, Jiaxin Xu, Kun Jia, Yulin Wu, Wei Yuan, Zhipeng Liao, Bo Cheng, Qiang Luo, Guiyou Tian, Huiqiang Lu
Butylparaben, a common endocrine disruptor in the environment, is known to be toxic to the reproductive system, heart, and intestines, but its nephrotoxicity has rarely been reported. In order to study the nephrotoxicity and mechanism of butylparaben, we examined the acute and chronic effects on human embryonic kidney cells (HEK293T) and zebrafish. Additionally, we assessed the potential remedial effects of salidroside against butylparaben-induced nephrotoxicity. Our in vitro findings demonstrated oxidative stress and cytotoxicity to HEK293T cells caused by butylparaben...
March 29, 2024: Journal of Hazardous Materials
#7
JOURNAL ARTICLE
Tjessa Bondue, Laleh Khodaparast, Ladan Khodaparast, Sara Cairoli, Bianca Maria Goffredo, Rik Gijsbers, Lambertus van den Heuvel, Elena Levtchenko
Cystinosis is an autosomal recessive lysosomal storage disorder, caused by mutations in the CTNS gene , resulting in an absent or altered cystinosin (CTNS) protein. Cystinosin exports cystine out of the lysosome, with a malfunction resulting in cystine accumulation and a defect in other cystinosin-mediated pathways. Cystinosis is a systemic disease, but the kidneys are the first and most severely affected organs. In the kidney, the disease initially manifests as a generalized dysfunction in the proximal tubules (also called renal Fanconi syndrome)...
March 28, 2024: American Journal of Physiology. Renal Physiology
#8
JOURNAL ARTICLE
Xing-Yue Zhang, Qi-Wu Jiang, Su-Han Yang, Ping Li, Zhi-Yong Chang, Fei Li
ETHNOPHARMACOLOGICAL RELEVANCE: Cistanche tubulosa (CT) is the dried fleshy stem with scaly leaves of Cistanche tubiflora (Schenk) Wight, which has the effects of tonifying the kidney-yang, benefiting the vital essence and blood, and moisturizing the intestines and laxatives. There are differences in the activity of CT before and after processing, but the mechanism of processing is not clear. AIM OF THE STUDY: The study aimed to compare the strength of action of CT before and after yellow-wine processing in the treatment of constipation and kidney yang deficiency and to identify the active ingredients responsible for the differences in activity before and after yellow-wine processing...
March 24, 2024: Journal of Ethnopharmacology
#9
JOURNAL ARTICLE
E H T Thulshan Jayathilaka, Mawallage Kankanamge Hasitha Madhawa Dias, Chamilani Nikapitiya, Mahanama De Zoysa
Bacterial extracellular vesicles (BEVs) are nanosized structures that play a role in intercellular communication and transport of bioactive molecules. Streptococcus parauberis is a Gram-positive pathogenic bacterium that causes "Streptococcosis" in fish. In this study, we isolated S. parauberis-derived extracellular vesicles (SpEVs), and then physicochemical and immunomodulatory properties were determined to elucidate their biological functions. Initially, the biogenesis of SpEVs was detected using field emission electron microscopy, which revealed that secretory phase SpEVs attached to the outer surface of S...
March 20, 2024: Fish & Shellfish Immunology
#10
JOURNAL ARTICLE
Chongbin Hu, Nan Zhang, Yun Hong, Ruxiu Tie, Dongdong Fan, Aifu Lin, Ye Chen, Li-Xin Xiang, Jian-Zhong Shao
The vertebrate kidneys play two evolutionary conserved roles in waste excretion and osmoregulation. Besides, the kidney of fish is considered as a functional ortholog of mammalian bone marrow that serves as a hematopoietic hub for generating blood cell lineages and immunological responses. However, knowledge about the properties of kidney hematopoietic cells, and the functionality of the kidney in fish immune systems remains to be elucidated. To this end, our present study generated a comprehensive atlas with 59 hematopoietic stem/progenitor cell (HSPC) and immune-cells types from zebrafish kidneys via single-cell transcriptome profiling analysis...
March 18, 2024: ELife
#11
JOURNAL ARTICLE
Wenmin Yang, Xiaoliang Liu, Zhongwei He, Yunfeng Zhang, Xiaoqin Tan, Chi Liu
The proximal convoluted tubule (PCT) of the kidney is a crucial functional segment responsible for reabsorption, secretion, and the maintenance of electrolyte and water balance within the renal tubule. However, there is a lack of a well-defined endogenous transgenic line for studying PCT morphogenesis. By analyzing single-cell transcriptome data from the adult zebrafish kidney, we have identified the expression of odd-skipped-related 2 ( osr2 , which encodes an odd-skipped zinc-finger transcription factor) in the PCT...
March 30, 2024: Heliyon
#12
JOURNAL ARTICLE
Dongdong Bi, Anneke Van Hal, Dennis Aschmann, Mengjie Shen, Heyang Zhang, Lu Su, Gabriela Arias-Alpizar, Alexander Kros, Matthias Barz, Jeroen Bussmann
Improving target versus off-target ratio in nanomedicine remains a major challenge for increasing drug bioavailability and reducing toxicity. Active targeting using ligands on nanoparticle surfaces is a key approach but has limited clinical success. A potential issue is the integration of targeting ligands also changes the physicochemical properties of nanoparticles (passive targeting). Direct studies to understand the mechanisms of active targeting and off-targeting in vivo are limited by the lack of suitable tools...
March 15, 2024: Small
#13
JOURNAL ARTICLE
Biswajit Padhy, Mohammad Amir, Jian Xie, Chou-Long Huang
Mutations of PKD1 coding for polycystin-1 (PC1) account for most cases of autosomal-dominant polycystic kidney disease (ADPKD). The extracellular region of PC1 contains many evolutionarily conserved domains for ligand interactions. Among these are the leucine-rich repeats (LRRs) in the far N-terminus of PC1. Using zebrafish ( Danio rerio ) as an in vivo model system, we explored the role of LRRs in the function of PC1. Zebrafish expresses two human PKD1 paralogs, pkd1a and pkd1b . Knockdown of both genes in zebrafish by morpholino antisense oligonucleotides produced phenotypes of dorsal-axis curvature and pronephric cyst formation...
March 1, 2024: International Journal of Molecular Sciences
#14
JOURNAL ARTICLE
Maryam Mahjoubian, Akram Sadat Naeemi, Mehdi Sheykhan
This study was conducted to assess the toxicological potential of synthesized pure and Sn-doped TiO2 NPs (Sn-TiO2 NPs) in zebrafish after acute and chronic exposure. The pure TiO2 NPs, 4%, and 8% Sn-TiO2 NPs were synthesized and characterized using X-ray diffraction, Scanning Electron Microscope, diffuse reflectance spectra, dynamic light scattering, and zeta potential analyses. The pure TiO2 NPs, 4%, and 8% Sn-TiO2 NPs were spherical with average sizes of about 40, 28, and 21 nm, respectively, indicating significant size reduction of TiO2 NPs following Sn doping...
March 12, 2024: Biological Trace Element Research
#15
JOURNAL ARTICLE
Le Yang, Chong Wang, Yuhong Huang, Baohong Xu, Yi Liu, Jianbo Yu, Liming Xiong, Tiaoyi Xiao, Qiaolin Liu
Proteins from the C1q domain-containing (C1qDC) family recognize self-, non-self-, and altered-self ligands and serves as an initiator molecule for the classical complement pathway as well as recognizing immune complexes. In this study, C1qDC gene family members were identified and analyzed in grass carp (Ctenopharyngodon idellus). Members of the C1q subfamily were cloned, and their response to infection with the grass carp virus was investigated. In the grass carp genome, 54 C1qDC genes and 67 isoforms have been identified...
March 4, 2024: Fish & Shellfish Immunology
#16
JOURNAL ARTICLE
Jil D Stegmann, Jeshurun C Kalanithy, Gabriel C Dworschak, Nina Ishorst, Enrico Mingardo, Filipa M Lopes, Yee Mang Ho, Phillip Grote, Tobias T Lindenberg, Öznur Yilmaz, Khadija Channab, Steve Seltzsam, Shirlee Shril, Friedhelm Hildebrandt, Felix Boschann, André Heinen, Angad Jolly, Katherine Myers, Kim McBride, Mir Reza Bekheirnia, Nasim Bekheirnia, Marcello Scala, Manuela Morleo, Vincenzo Nigro, Annalaura Torella, Michele Pinelli, Valeria Capra, Andrea Accogli, Silvia Maitz, Alice Spano, Rory J Olson, Eric W Klee, Brendan C Lanpher, Se Song Jang, Jong-Hee Chae, Philipp Steinbauer, Dietmar Rieder, Andreas R Janecke, Julia Vodopiutz, Ida Vogel, Jenny Blechingberg, Jennifer L Cohen, Kacie Riley, Victoria Klee, Laurence E Walsh, Matthias Begemann, Miriam Elbracht, Thomas Eggermann, Arzu Stoppe, Kyra Stuurman, Marjon van Slegtenhorst, Tahsin Stefan Barakat, Maureen S Mulhern, Tristan T Sands, Cheryl Cytrynbaum, Rosanna Weksberg, Federica Isidori, Tommaso Pippucci, Giulia Severi, Francesca Montanari, Michael C Kruer, Somayeh Bakhtiari, Hossein Darvish, Heiko Reutter, Gregor Hagelueken, Matthias Geyer, Adrian S Woolf, Jennifer E Posey, James R Lupski, Benjamin Odermatt, Alina C Hilger
CELSR3 codes for a planar cell polarity protein. We describe twelve affected individuals from eleven independent families with bi-allelic variants in CELSR3. Affected individuals presented with an overlapping phenotypic spectrum comprising central nervous system (CNS) anomalies (7/12), combined CNS anomalies and congenital anomalies of the kidneys and urinary tract (CAKUT) (3/12) and CAKUT only (2/12). Computational simulation of the 3D protein structure suggests the position of the identified variants to be implicated in penetrance and phenotype expression...
March 1, 2024: NPJ Genomic Medicine
#17
REVIEW
Mark Kreychman, Emma Ivantsova, Austin Lu, Joseph H Bisesi, Christopher J Martyniuk
Industrial and consumer goods contain diverse perfluoroalkyl substances (PFAS). These substances, like perfluorohexanoic acid (PFHxA) and perfluorohexanesulphonic acid (PFHxS), are under increased scrutiny due to their potential toxicity to aquatic organisms. However, our understanding of their biological impacts and mechanisms of action remains limited. The objectives of this review were to compare data for levels of PFHxA and PFHxS in aquatic environments and fish tissues, as well as toxicity mechanisms related to morphological, endocrine, metabolic, and behavioral endpoints...
February 27, 2024: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
#18
JOURNAL ARTICLE
Hannah M Wesselman, Rebecca A Wingert
While traditionally recognized as a sex hormone, estrogen has a potent effect on the development of tissues beyond those of the reproductive system. Estrogen synthesis enzymes and estrogen receptors are broadly expressed in vertebrate tissues, further indicating their importance in various processes. These include the tissues of the zebrafish, which is a particularly suitable model for studying early development due to its rapid ex utero ontogeny and conserved genetic and cellular composition with other vertebrates...
February 22, 2024: International Journal of Developmental Biology
#19
JOURNAL ARTICLE
Pan-Pan Jia, Yan Li, Lan-Chen Zhang, Ming-Fei Wu, Tian-Yun Li, De-Sheng Pei
It is still a serious public health issue that chronic kidney disease of uncertain etiology (CKDu) in Sri Lanka poses challenges in identification, prevention, and treatment. What environmental factors in drinking water cause kidney damage remains unclear. This study aimed to investigate the risks of various environmental factors that may induce CKDu, including water hardness, fluoride (HF), heavy metals (HM), microcystin-LR (MC-LR), and their combined exposure (HFMM). The research focused on comprehensive metabolome analysis, and correlation with transcriptomic and gut microbiota changes...
February 26, 2024: Ecotoxicology and Environmental Safety
#20
JOURNAL ARTICLE
Barbara Nunes Padovani, Camila Morales Fénero, Lais Cavalieri Paredes, Mariana Abrantes do Amaral, Omar Domínguez-Amorocho, Marcella Cipelli, Juliana Moreira Mendonça Gomes, Eloisa Martins da Silva, Luísa Menezes Silva, Raquel de Souza Vieira, Mariana Tominaga Pereira, Mario Costa Cruz, Niels Olsen Saraiva Câmara
Cisplatin is an antineoplastic agent used to treat various tumors. In mammals, it can cause nephrotoxicity, tissue damage, and inflammation. The release of inflammatory mediators leads to the recruitment and infiltration of immune cells, particularly neutrophils, at the site of inflammation. Cisplatin is often used as an inducer of acute kidney injury (AKI) in experimental models, including zebrafish ( Danio rerio ), due to its accumulation in kidney cells. Current protocols in larval zebrafish focus on studying its effect as an AKI inducer but ignore other systematic outcomes...
February 17, 2024: International Journal of Molecular Sciences
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