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oligometastasis

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https://www.readbyqxmd.com/read/27755813/clinical-outcome-of-node-negative-oligometastatic-non-small-cell-lung-cancer
#1
Kiyohiro Sakai, Masayuki Takeda, Hidetoshi Hayashi, Kaoru Tanaka, Takeshi Okuda, Amami Kato, Yasumasa Nishimura, Tetsuya Mitsudomi, Atsuko Koyama, Kazuhiko Nakagawa
INTRODUCTION: The concept of "oligometastasis" has emerged as a basis on which to identify patients with stage IV non-small cell lung cancer (NSCLC) who might be most amenable to curative treatment. Limited data have been available regarding the survival of patients with node-negative oligometastatic NSCLC. PATIENTS AND METHODS: Consecutive patients with advanced NSCLC who attended Kindai University Hospital between January 2007 and January 2016 were recruited to this retrospective study...
September 12, 2016: Thoracic Cancer
https://www.readbyqxmd.com/read/27725639/oligometastatic-prostate-cancer-definitions-clinical-outcomes-and-treatment-considerations
#2
REVIEW
Jeffrey J Tosoian, Michael A Gorin, Ashley E Ross, Kenneth J Pienta, Phuoc T Tran, Edward M Schaeffer
The oligometastatic state has been proposed as an intermediate stage of cancer spread between localized disease and widespread metastases. With improvements in diagnostic modalities such as functional imaging, oligometastatic prostate cancer is being diagnosed with greater frequency than ever before. Furthermore, the paradigm for treatment of advanced prostate cancers is shifting toward a more aggressive approach. Many questions surround the understanding of the process and consequences of oligometastasis, meaning that the contemporary literature offers a wide variety of definitions of oligometastatic prostate cancer...
October 11, 2016: Nature Reviews. Urology
https://www.readbyqxmd.com/read/27722895/high-preoperative-serum-ca19-9-level-is-predictive-of-poor-prognosis-for-patients-with-colorectal-liver-oligometastases-undergoing-hepatic-resection
#3
Zhenhai Lu, Jianhong Peng, Zhiqiang Wang, Zhizhong Pan, Yunfei Yuan, Desen Wan, Binkui Li
Oligometastasis is defined as a transitional state between localized and widespread systemic metastatic cancers. In colorectal cancer, the prognostic factors and prognostic value of preoperative serum carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) for patients with colorectal liver oligometastases (CLOM) undergoing hepatic resection have not been well explored. Therefore, the present study included 141 patients with CLOM (≤5 liver metastases) who underwent R0 resection from 2005 to 2012...
November 2016: Medical Oncology
https://www.readbyqxmd.com/read/27674876/single-fraction-stereotactic-ablative-body-radiation-therapy-as-an-effective-management-of-oligometastasis-results-from-133-consecutive-patients
#4
S Gandhidasan, M Bressel, T Kron, M Shaw, J Chu, S Chander, G Wheeler, N Plumridge, B Chesson, A Haworth, S P David, D Ball, S Siva
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27670890/radiosensitivity-of-colon-and-rectal-lung-oligometastasis-treated-with-stereotactic-ablative-radiotherapy
#5
Rémy Kinj, Pierre-Yves Bondiau, Eric François, Jean-Pierre Gérard, Arash O Naghavi, Axel Leysalle, Emmanuel Chamorey, Ludovic Evesque, Bernard Padovani, Antoine Ianessi, Karen Benezery, Jérôme Doyen
INTRODUCTION: Patients with metastatic colorectal cancer (CRC) may present with oligometastatic lung lesions for which stereotactic ablative radiotherapy (SABR) can be utilized. This study aims to report efficacy and prognostic factors associated with colorectal lung metastases treated with SABR. MATERIAL AND METHODS: This is a retrospective study including patients who presented with lung oligometastasis from CRC treated with SABR from September 2007 to November 2014...
August 31, 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/27606082/stereotactic-body-radiotherapy-current-strategies-and-future-development
#6
REVIEW
Maverick W K Tsang
Stereotactic body radiotherapy (SBRT) has emerged as the standard treatment for medically inoperable early-staged non-small cell lung cancer (NSCLC). The local control rate after SBRT is over 90%. Some forms of tumour motion management and image-guided radiation delivery techniques are the prerequisites for fulfilment of its goal to deliver a high radiation dose to the tumour target without overdosing surrounding normal tissues. In this review, the current strategies of tumour motion management will be discussed, followed by an overview of various image-guided radiotherapy (RT) systems and devices available for clinical practice...
July 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27494974/-not-available
#7
Juliette Thariat, Stéphane Vignot
Oligometastic progression (or solitary metastases) can justify ablative treatment for metastatic treatment. When such a strategy is discussed, it is important to notice that definition of oligometastases is not consensual both in terms of clinical presentation than on the biological basis. Does a specific biological background truly exist and are there markers that could predict for additional occult disease and its oligo or polymetastatic profile in individuals with demonstrated oligometastasis. This article provides a summary of the state of the art in this field and highlights some current areas of controversies...
June 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/27471395/survival-prognostic-factors-for-patients-with-synchronous-brain-oligometastatic-non-small-cell-lung-carcinoma-receiving-local-therapy
#8
Hao Bai, Jianlin Xu, Haitang Yang, Bo Jin, Yuqing Lou, Dan Wu, Baohui Han
INTRODUCTION: Clinical evidence for patients with synchronous brain oligometastatic non-small-cell lung carcinoma is limited. We aimed to summarize the clinical data of these patients to explore the survival prognostic factors for this population. METHODS: From September 1995 to July 2011, patients with 1-3 synchronous brain oligometastases, who were treated with stereotactic radiosurgery (SRS) or surgical resection as the primary treatment, were identified at Shanghai Chest Hospital...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27441744/stereotactic-body-radiotherapy-for-oligometastasis-opportunities-for-biology-to-guide-clinical-management
#9
Rohann J M Correa, Joseph K Salama, Michael T Milano, David A Palma
Oligometastasis refers to a state of limited metastatic disease burden, in which surgical or ablative treatment to all known visible metastases holds promise to extend survival or even effect cure. Stereotactic body radiotherapy is a form of radiation treatment capable of delivering a high biologically effective dose of radiation in a highly conformal manner, with a favorable toxicity profile. Enthusiasm for oligometastasis ablation, however, should be counterbalanced against the limited supporting evidence...
July 2016: Cancer Journal
https://www.readbyqxmd.com/read/27385094/combined-ct-guided-radiofrequency-ablation-with-systemic-chemotherapy-improves-the-survival-for-nasopharyngeal-carcinoma-with-oligometastasis-in-liver-propensity-score-matching-analysis
#10
Wang Li, Yutong Bai, Ming Wu, Lujun Shen, Feng Shi, Xuqi Sun, Caijin Lin, Boyang Chang, Changchuan Pan, Zhiwen Li, Peihong Wu
The aim of this study was to retrospectively compare the treatment efficacy of systemic chemotherapy combined with sequential CT-guided radiofrequency ablation (Chemo-RFA) to chemotherapy alone (Chemo-only) in the management of nasopharyngeal carcinoma (NPC) with liver metastasis. Between 2003 and 2011, 328 NPC patients diagnosed with liver metastasis at Sun Yat-sen University Cancer Center were enrolled. One-to-one matched pairs between Chemo-RFA group with the Chemo-only group were generated using propensity score matching...
July 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/27206146/clinical-and-molecular-markers-of-long-term-survival-after-oligometastasis-directed-stereotactic-body-radiotherapy-sbrt
#11
Anthony C Wong, Sydeaka P Watson, Sean P Pitroda, Christina H Son, Lauren C Das, Melinda E Stack, Abhineet Uppal, Go Oshima, Nikolai N Khodarev, Joseph K Salama, Ralph R Weichselbaum, Steven J Chmura
BACKGROUND: The selection of patients for oligometastasis-directed ablative therapy remains a challenge. The authors report on clinical and molecular predictors of survival from a stereotactic body radiotherapy (SBRT) dose-escalation trial for oligometastases. METHODS: Patients who had from 1 to 5 metastases, a life expectancy of >3 months, and a Karnofsky performance status of >60 received escalating SBRT doses to all known cancer sites. Time to progression, progression-free survival, and overall survival (OS) were calculated at the completion of SBRT, and clinical predictors of OS were modeled...
July 15, 2016: Cancer
https://www.readbyqxmd.com/read/27141207/prostate-cancer-nodal-oligometastasis-accurately-assessed-using-prostate-specific-membrane-antigen-positron-emission-tomography-computed-tomography-and-confirmed-histologically-following-robotic-assisted-lymph-node-dissection
#12
Dermot B O'Kane, Nathan Lawrentschuk, Damien M Bolton
We herein present a case of a 76-year-old gentleman, where prostate-specific membrane antigen positron emission tomography-computed tomography (PSMA PET-CT) was used to accurately detect prostate cancer (PCa), pelvic lymph node (LN) metastasis in the setting of biochemical recurrence following definitive treatment for PCa. The positive PSMA PET-CT result was confirmed with histological examination of the involved pelvic LNs following pelvic LN dissection.
April 2016: Urology Annals
https://www.readbyqxmd.com/read/27078719/stereotactic-body-radiotherapy-for-oligometastatic-breast-cancer-a-new-standard-of-care-or-a-medical-reversal-in-waiting
#13
Michael W Drazer, Joseph K Salama, Olwen M Hahn, Ralph R Weichselbaum, Steven J Chmura
Metastases-directed therapy via surgery or stereotactic body radiotherapy (SBRT) has become the de facto standard of care in the United States and abroad despite a lack of high quality prospective, randomized trials. Oligometastatic tumors may behave in an inherently more indolent manner secondary to underlying biologic characteristics, including discrepant microRNA expression patterns. This biologic discrepancy suggests that historic improvements in survival observed in retrospective series may stem from the inherent biology of oligometastases and selection biases as opposed to advances in novel localized treatments...
June 2016: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/27013896/osseous-oligometastases-from-thymic-carcinoma-a-case-report-suggesting-the-effectiveness-of-palliative-intent-radiotherapy-treatment
#14
Jumpei Kashima, Hirotoshi Horio, Yusuke Okuma, Yukio Hosomi, Tsunekazu Hishima
BACKGROUND: Oligometastasis, a recently proposed concept, is defined as an intermediate state of cancer, between localized and systemic disease, that may be well controlled by local ablative treatment. Thymic carcinoma is a rare cancer with a poor prognosis. A definitive management approach has yet to be confirmed by a high level of evidence. CASE PRESENTATION: We present the case of a 41-year-old female who underwent curative-intent surgery for a stage III squamous cell carcinoma of the thymus...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/26988829/-analysis-of-the-therapeutic-effects-of-different-treatment-modalities-on-the-outcomes-of-87-patients-with-lung-oligometastasis-from-nasopharyngeal-carcinoma-after-radiotherapy
#15
Q Tang, Q Y Hu, Y F Piao, Y H Hua, X Z Chen
OBJECTIVE: The aim of the present study was to evaluate the efficacy of three different modalities in treatment of lung oligometastases from nasopharyngeal carcinoma (NPC) after radiotherapy and to identify a more appropriate treatment modality. METHODS: The clinical data of 87 cases of lung oligometastases from NPC were analyzed retrospectively. Among them, 33 patients underwent local small-field irradiation+ /- chemotherapy, 28 underwent whole-lung irradiation+ chemotherapy, and 26 underwent simple chemotherapy...
March 23, 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/26895202/approach-for-oligometastasis-in-non-small-cell-lung-cancer
#16
REVIEW
Hidemi Suzuki, Ichiro Yoshino
Non-small cell lung cancer (NSCLC) harboring a limited number of distant metastases, referred to as the oligometastatic state, has been indicated for surgery for the past several decades. However, whether the strategy of surgical treatment results in a survival benefit for such patients remains controversial. Experientially, however, thoracic surgeons often encounter long-term survivors among surgically resected oligometastatic NSCLC patients. In this article, the current situation of surgical approach and potential future perspective for oligometastatic NSCLC are reviewed...
April 2016: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/26807417/robotic-adrenalectomy-for-sigmoid-colon-cancer-oligometastasis
#17
Vishwas D Pai, Manish Bhandare, Kedar Deodhar, Thyavihally Boregowda Yuvaraja, Avanish P Saklani
Solitary adrenal metastasis from colorectal cancer is rare with reported incidence from 3.1% to 14.4% in the literature. Conventionally, adrenal metastasis is considered as indicative of widespread systemic disease and hence treated with palliative intent. Surgical resection remains controversial although a median survival of 32 months was found in the largest reported case series. It has been postulated that surgical resection should be offered when the adrenal metastasis develops more than 6 months after the treatment of the primary tumor...
December 2015: Annals of Translational Medicine
https://www.readbyqxmd.com/read/26793890/-multimodality-therapy-for-high-risk-prostate-cancer
#18
Shingo Hatakeyama, Chikara Ohyama
Multimodal approach should be provided for high-risk prostate cancer patients. Androgen deprivation therapy (ADT) is a standard adjunct to radiotherapy for high-risk prostate cancer, but its role around prostatectomy has not been clearly defined. In a well-selected patient group, radical prostatectomy with adjuvant or salvage treatment when needed can yield very high long-term cancer control and survival rates. The role of pelvic lymph node dissection during radical prostatectomy is still controversial. Recent randomized controlled trials have demonstrated improved outcomes with the combination of radiotherapy in conjunction with ADT and docetaxel for high-risk prostate cancer...
January 2016: Nihon Rinsho. Japanese Journal of Clinical Medicine
https://www.readbyqxmd.com/read/26791943/clinical-outcome-of-stereotactic-body-radiotherapy-for-primary-and-oligometastatic-lung-tumors-a-single-institutional-study-with-almost-uniform-dose-with-different-five-treatment-schedules
#19
Masahiko Aoki, Yoshiomi Hatayama, Hideo Kawaguchi, Katsumi Hirose, Mariko Sato, Hiroyoshi Akimoto, Ichitaro Fujioka, Shuichi Ono, Eiki Tsushima, Yoshihiro Takai
BACKGROUND: To evaluate clinical outcomes of stereotactic body radiotherapy (SBRT) for localized primary and oligometastatic lung tumors by assessing efficacy and safety of 5 regimens of varying fraction size and number. METHODS: One-hundred patients with primary lung cancer (n = 69) or oligometastatic lung tumors (n = 31), who underwent SBRT between May 2003 and August 2010, were included. The median age was 75 years (range, 45-88). Of them, 98 were judged to have medically inoperable disease, predominantly due to chronic illness or advanced age...
2016: Radiation Oncology
https://www.readbyqxmd.com/read/26626571/new-strategies-in-stereotactic-radiotherapy-for-oligometastases
#20
REVIEW
David A Palma, Alexander V Louie, George B Rodrigues
Patients with metastatic solid tumors are usually treated with palliative intent. Systemic therapy and palliative radiation are often used, with the goals of prolonging survival or maintaining quality of life, but not of cure. In contrast to this paradigm, the theory of oligometastasis suggests that some patients who have a small number of metastases may be amenable to cure if all lesions can be eradicated. Aggressive treatment of patients with oligometastases, using either surgery or radiotherapy, has become more common in the past decade, yet in most situations, no randomized evidence is available to support such an approach...
December 1, 2015: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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