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FMRI and epilepsy

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https://www.readbyqxmd.com/read/29782369/neuroimaging-in-epilepsy
#1
Meneka Kaur Sidhu, John S Duncan, Josemir W Sander
PURPOSE OF REVIEW: Epilepsy neuroimaging is important for detecting the seizure onset zone, predicting and preventing deficits from surgery and illuminating mechanisms of epileptogenesis. An aspiration is to integrate imaging and genetic biomarkers to enable personalized epilepsy treatments. RECENT FINDINGS: The ability to detect lesions, particularly focal cortical dysplasia and hippocampal sclerosis, is increased using ultra high-field imaging and postprocessing techniques such as automated volumetry, T2 relaxometry, voxel-based morphometry and surface-based techniques...
May 17, 2018: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29740294/converging-evidence-from-electrocorticography-and-bold-fmri-for-a-sharp-functional-boundary-in-superior-temporal-gyrus-related-to-multisensory-speech-processing
#2
Muge Ozker, Daniel Yoshor, Michael S Beauchamp
Although humans can understand speech using the auditory modality alone, in noisy environments visual speech information from the talker's mouth can rescue otherwise unintelligible auditory speech. To investigate the neural substrates of multisensory speech perception, we compared neural activity from the human superior temporal gyrus (STG) in two datasets. One dataset consisted of direct neural recordings (electrocorticography, ECoG) from surface electrodes implanted in epilepsy patients (this dataset has been previously published)...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29740268/study-of-resting-state-functional-connectivity-networks-using-eeg-electrodes-position-as-seed
#3
Gonzalo M Rojas, Carolina Alvarez, Carlos E Montoya, María de la Iglesia-Vayá, Jaime E Cisternas, Marcelo Gálvez
Electroencephalography (EEG) is the standard diagnosis method for a wide variety of diseases such as epilepsy, sleep disorders, encephalopathies, and coma, among others. Resting-state functional magnetic resonance (rs-fMRI) is currently a technique used in research in both healthy individuals as well as patients. EEG and fMRI are procedures used to obtain direct and indirect measurements of brain neural activity: EEG measures the electrical activity of the brain using electrodes placed on the scalp, and fMRI detects the changes in blood oxygenation that occur in response to neural activity...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29681927/altered-structural-and-functional-connectivity-of-juvenile-myoclonic-epilepsy-an-fmri-study
#4
Chengqing Zhong, Rong Liu, Cheng Luo, Sisi Jiang, Li Dong, Rui Peng, Fuqiang Guo, Pu Wang
The aim of this study was to investigate the structural and functional connectivity (FC) of juvenile myoclonic epilepsy (JME) using resting state functional magnetic resonance imaging (rs-fMRI). High-resolution T1-weighted magnetic resonance imaging (MRI) and rs-fMRI data were collected in 25 patients with JME and in 24 control subjects. A FC analysis was subsequently performed, with seeding at the regions that demonstrated between-group differences in gray matter volume (GMV). Then, the observed structural and FCs were associated with the clinical manifestations...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29528160/presurgical-language-fmri-clinical-practices-and-patient-outcomes-in-epilepsy-surgical-planning
#5
Christopher F A Benjamin, Alexa X Li, Hal Blumenfeld, R Todd Constable, Rafeed Alkawadri, Stephan Bickel, Christoph Helmstaedter, Stefano Meletti, Richard Bronen, Simon K Warfield, Jurriaan M Peters, David Reutens, Monika Połczyńska, Dennis D Spencer, Lawrence J Hirsch
The goal of this study was to document current clinical practice and report patient outcomes in presurgical language functional MRI (fMRI) for epilepsy surgery. Epilepsy surgical programs worldwide were surveyed as to the utility, implementation, and efficacy of language fMRI in the clinic; 82 programs responded. Respondents were predominantly US (61%) academic programs (85%), and evaluated adults (44%), adults and children (40%), or children only (16%). Nearly all (96%) reported using language fMRI. Surprisingly, fMRI is used to guide surgical margins (44% of programs) as well as lateralize language (100%)...
March 12, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29527492/brain-functional-connectivity-in-sleep-related-hypermotor-epilepsy
#6
Stefania Evangelisti, Claudia Testa, Lorenzo Ferri, Laura Ludovica Gramegna, David Neil Manners, Giovanni Rizzo, Daniel Remondini, Gastone Castellani, Ilaria Naldi, Francesca Bisulli, Caterina Tonon, Paolo Tinuper, Raffaele Lodi
Objectives: To evaluate functional connectivity (FC) in patients with sleep-related hypermotor epilepsy (SHE) compared to healthy controls. Methods: Resting state fMRI was performed in 13 patients with a clinical diagnosis of SHE (age = 38.3 ± 11.8 years, 6 M) and 13 matched healthy controls (age = 38.5 ± 10.8 years, 6 M).Data were first analysed using probabilistic independent component analysis (ICA), then a graph theoretical approach was applied to assess topological and organizational properties at the whole brain level...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29501535/encoding-and-immediate-retrieval-tasks-in-patients-with-epilepsy-a-functional-mri-study-of-verbal-and-visual-memory
#7
REVIEW
Najat Saddiki, Sophie Hennion, Romain Viard, Nassima Ramdane, Renaud Lopes, Marc Baroncini, William Szurhaj, Nicolas Reyns, Jean Pierre Pruvo, Christine Delmaire
PURPOSE: Medial lobe temporal structures and more specifically the hippocampus play a decisive role in episodic memory. Most of the memory functional magnetic resonance imaging (fMRI) studies evaluate the encoding phase; the retrieval phase being performed outside the MRI. We aimed to determine the ability to reveal greater hippocampal fMRI activations during retrieval phase. MATERIALS AND METHODS: Thirty-five epileptic patients underwent a two-step memory fMRI...
March 1, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29499551/task-activation-and-functional-connectivity-show-concordant-memory-laterality-in-temporal-lobe-epilepsy
#8
Noah Sideman, Ganne Chaitanya, Xiaosong He, Gaelle Doucet, Na Young Kim, Michael R Sperling, Ashwini D Sharan, Joseph I Tracy
OBJECTIVE: In epilepsy, asymmetries in the organization of mesial temporal lobe (MTL) functions help determine the cognitive risk associated with procedures such as anterior temporal lobectomy. Past studies have investigated the change/shift in a visual episodic memory laterality index (LI) in mesial temporal lobe structures through functional magnetic resonance imaging (fMRI) task activations. Here, we examine whether underlying task-related functional connectivity (FC) is concordant with such standard fMRI laterality measures...
April 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29477011/adapting-a-memory-fmri-research-protocol-in-clinical-routine-feasibility-and-results
#9
Ovidio Solano Cabrera, Stéphane Lehéricy, Véronique Masson, Séverine Samson, Sophie Dupont
OBJECTIVE: The objective of this study was to test the reliability of functional magnetic resonance imaging (fMRI) evaluation of memory function in clinical practice to predict postoperative memory decline in patients with refractory medial temporal lobe epilepsy (MTLE) candidate to surgery. METHODS: Twenty-six consecutive patients with MTLE who underwent a complete presurgical evaluation were included. All patients underwent fMRI memory study and complete neuropsychological assessment...
April 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29475172/brain-network-alteration-in-patients-with-temporal-lobe-epilepsy-with-cognitive-impairment
#10
Hongyu Yang, Chao Zhang, Chang Liu, Tao Yu, Guojun Zhang, Nan Chen, Kuncheng Li
The aims of this study were to investigate the brain network alternation in patients with temporal lobe epilepsy (TLE) with and without cognitive impairment (CI) using functional magnetic resonance imaging (fMRI) and to further explore the potential mechanisms of epilepsy-induced CI. Forty patients with TLE and nineteen healthy controls (HCs) were recruited for this study. All participants received the Montreal Cognitive Assessment (MoCA) test, and the patients were divided into CI (n=21) and cognitive nonimpairment (CNI) groups (n=19) according to MoCA performance...
April 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29414405/eeg-synchronization-measures-predict-epilepsy-related-bold-fmri-fluctuations-better-than-commonly-used-univariate-metrics
#11
Rodolfo Abreu, Alberto Leal, Fernando Lopes da Silva, Patrícia Figueiredo
OBJECTIVE: We hypothesize that the hypersynchronization associated with epileptic activity is best described by EEG synchronization measures, and propose to use these as predictors of epilepsy-related BOLD fluctuations. METHODS: We computed the phase synchronization index (PSI) and global field synchronization (GFS), within two frequency bands, a broadband (1-45 Hz) and a narrower band focused on the presence of epileptic activity (3-10 Hz). The associated epileptic networks were compared with those obtained using conventional unitary regressors and two power-weighted metrics (total power and root mean square frequency), on nine simultaneous EEG-fMRI datasets from four epilepsy patients, exhibiting inter-ictal epileptiform discharges (IEDs)...
March 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29414401/predicting-postoperative-language-outcome-using-presurgical-fmri-meg-tms-and-high-gamma-ecog
#12
Abbas Babajani-Feremi, Christen M Holder, Shalini Narayana, Stephen P Fulton, Asim F Choudhri, Frederick A Boop, James W Wheless
OBJECTIVE: To predict the postoperative language outcome using the support vector regression (SVR) and results of multimodal presurgical language mapping. METHODS: Eleven patients with epilepsy received presurgical language mapping using functional MRI (fMRI), magnetoencephalography (MEG), transcranial magnetic stimulation (TMS), and high-gamma electrocorticography (hgECoG), as well as pre- and postoperative neuropsychological evaluation of language. We constructed 15 (24 -1) SVR models by considering the extent of resected language areas identified by all subsets of four modalities as input feature vector and the postoperative language outcome as output...
March 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29406962/altered-spontaneous-brain-activity-in-mri-negative-refractory-temporal-lobe-epilepsy-patients-with-major-depressive-disorder-a-resting-state-fmri-study
#13
Xi Zhu, Zhongqiong He, Cheng Luo, Xiangmiao Qiu, Shixu He, Anjiao Peng, Lin Zhang, Lei Chen
OBJECTIVE: To investigate alterations in spontaneous brain activity in MRI-negative refractory temporal lobe epilepsy patients with major depressive disorder using resting-state functional magnetic resonance imaging (RS-fMRI). METHODS: Eighteen MRI-negative refractory temporal lobe epilepsy patients with major depressive disorder (PDD), 17 MRI-negative refractory temporal lobe epilepsy patients without major depressive disorder (nPDD), and 21 matched healthy controls (HC) were recruited from West China Hospital of SiChuan University from April 2016 to June 2017...
March 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29376090/cognitive-impairment-in-epilepsy-the-role-of-reduced-network-flexibility
#14
Chris Tailby, Magdalena A Kowalczyk, Graeme D Jackson
Objective: The dominant model of cognitive impairment in focal epilepsy has emphasised structural bases for cognitive deficits. Current theories of cognition in the healthy brain emphasise the importance of the reweighting of brain network interactions in support of task performance. Here, we explore the hypothesis that cognitive deficits in epilepsy arise through abnormalities of dynamic functional network interactions. Method: We studied 19 healthy controls and 37 temporal lobe epilepsy (TLE) patients, using a behavioural measure of verbal fluency (the Controlled Oral Word Association Test) and an fMRI verbal fluency paradigm (Orthographic Lexical Retrieval)...
January 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29357371/evaluating-the-impact-of-fast-fmri-on-dynamic-functional-connectivity-in-an-event-based-paradigm
#15
Ashish Kaul Sahib, Michael Erb, Justus Marquetand, Pascal Martin, Adham Elshahabi, Silke Klamer, Serge Vulliemoz, Klaus Scheffler, Thomas Ethofer, Niels K Focke
The human brain is known to contain several functional networks that interact dynamically. Therefore, it is desirable to analyze the temporal features of these networks by dynamic functional connectivity (dFC). A sliding window approach was used in an event-related fMRI (visual stimulation using checkerboards) to assess the impact of repetition time (TR) and window size on the temporal features of BOLD dFC. In addition, we also examined the spatial distribution of dFC and tested the feasibility of this approach for the analysis of interictal epileptiforme discharges...
2018: PloS One
https://www.readbyqxmd.com/read/29351584/the-roles-of-left-versus-right-anterior-temporal-lobes-in-semantic-memory-a-neuropsychological-comparison-of-postsurgical-temporal-lobe-epilepsy-patients
#16
Grace E Rice, Helen Caswell, Perry Moore, Paul Hoffman, Matthew A Lambon Ralph
The presence and degree of specialization between the anterior temporal lobes (ATLs) is a key issue in debates about the neural architecture of semantic memory. Here, we comprehensively assessed multiple aspects of semantic cognition in a large group of postsurgical temporal lobe epilepsy (TLE) patients with left versus right anterior temporal lobectomy (n = 40). Both subgroups showed deficits in expressive and receptive verbal semantic tasks, word and object recognition, naming and recognition of famous faces and perception of faces and emotions...
April 1, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29327337/generalized-nonmotor-absence-seizures-what-do-absence-generalized-and-nonmotor-mean
#17
REVIEW
Iris Unterberger, Eugen Trinka, Peter W Kaplan, Gerald Walser, Gerhard Luef, Gerhard Bauer
OBJECTIVE: Clinical absences are now classified as "generalized nonmotor (absence) seizures" by the International League Against Epilepsy (ILAE). The aim of this paper is to critically review the concept of absences and to put the accompanying focal and motor symptoms into the context of the emerging pathophysiological knowledge. METHODS: For this narrative review we performed an extensive literature search on the term "absence," and analyzed the plethora of symptoms observed in clinical absences...
March 2018: Epilepsia
https://www.readbyqxmd.com/read/29321970/deepied-an-epileptic-discharge-detector-for-eeg-fmri-based-on-deep-learning
#18
Yongfu Hao, Hui Ming Khoo, Nicolas von Ellenrieder, Natalja Zazubovits, Jean Gotman
Presurgical evaluation that can precisely delineate the epileptogenic zone (EZ) is one important step for successful surgical resection treatment of refractory epilepsy patients. The noninvasive EEG-fMRI recording technique combined with general linear model (GLM) analysis is considered an important tool for estimating the EZ. However, the manual marking of interictal epileptic discharges (IEDs) needed in this analysis is challenging and time-consuming because the quality of the EEG recorded inside the scanner is greatly deteriorated compared to the usual EEG obtained outside the scanner...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29288994/detecting-sub-second-changes-in-brain-activation-patterns-during-interictal-epileptic-spike-using-simultaneous-eeg-fmri
#19
Epifanio Bagarinao, Satoshi Maesawa, Yuji Ito, Naotaka Usui, Jun Natsume, Hirohisa Watanabe, Minoru Hoshiyama, Toshihiko Wakabayashi, Gen Sobue, Shinji Naganawa, Haruo Isoda
OBJECTIVE: Epileptic spikes are associated with rapidly changing brain activation involving the epileptic foci and other brain regions in the "epileptic network". We aim to resolve these activation changes using simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) recordings. METHODS: Simultaneous EEG-fMRI recordings from 9 patients with epilepsy were used in the analysis. Our method employed the whole scalp EEG data to generate regressors for the analysis of fMRI data using the general linear model...
November 27, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29245083/concordance-between-the-wada-test-and-neuroimaging-lateralization-influence-of-imaging-modality-fmri-and-meg-and-patient-experience
#20
Steven Kemp, Garreth Prendergast, Theodoros Karapanagiotidis, Gus Baker, Thomas P Kelly, Tufail Patankar, Simon S Keller
The Wada test remains the traditional test for lateralizing language and memory function prior to epilepsy surgery. Functional imaging, particularly functional MRI (fMRI), has made progress in the language domain, but less so in the memory domain. Magnetoencephalography (MEG) has received less research attention, but shows promise, particularly for language lateralization. We recruited a consecutive sample of 19 patients with epilepsy who had completed presurgical work-up, including the Wada test, and compared fMRI (memory) and MEG (language and memory) with Wada test results...
January 2018: Epilepsy & Behavior: E&B
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