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FMRI and epilepsy

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https://www.readbyqxmd.com/read/28220524/language-fmri-and-direct-cortical-stimulation-in-epilepsy-preoperative-planning
#1
Alison Austermuehle, John Cocjin, Reynolds Richard, Shubhi Agrawal, Leigh Sepeta, William D Gaillard, Kareem Zaghloul, Sara Inati, William H Theodore
OBJECTIVE: Presurgical language assessment can help minimize damage to eloquent cortex during resective epilepsy surgery. Two methods for presurgical language mapping are functional MRI (fMRI) and direct cortical stimulation (DCS) of implanted subdural electrodes. We compared fMRI results to DCS to help optimize non-invasive language localization and assess its validity. METHODS: We studied 19 patients referred for presurgical evaluation of drug-resistant epilepsy...
February 21, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28213372/effect-of-topiramate-and-zonisamide-on-fmri-cognitive-networks
#2
Britta Wandschneider, Jane Burdett, Lucy Townsend, Andrea Hill, Pamela J Thompson, John S Duncan, Matthias J Koepp
OBJECTIVE: To investigate the effects of topiramate (TPM), zonisamide (ZNS), and levetiracetam (LEV) on cognitive network activations in patients with focal epilepsy using an fMRI language task. METHODS: In a retrospective, cross-sectional study, we identified patients from our clinical database of verbal fluency fMRI studies who were treated with either TPM (n = 32) or ZNS (n = 51). We matched 62 patients for clinical measures who took LEV but not TPM or ZNS. We entered antiepileptic comedications as nuisance variables and compared out-of-scanner psychometric measures for verbal fluency and working memory between groups...
February 17, 2017: Neurology
https://www.readbyqxmd.com/read/28199371/the-value-of-resting-state-functional-magnetic-resonance-imaging-for-detecting-epileptogenic-zones-in-patients-with-focal-epilepsy
#3
Zhijuan Chen, Yang An, Bofeng Zhao, Weidong Yang, Qing Yu, Li Cai, Hongyan Ni, Jianzhong Yin
OBJECTIVE: To determine the value of resting-state functional magnetic resonance imaging (RS-fMRI) based on the local analysis methods regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), and fractional ALFF (fALFF), for detecting epileptogenic zones (EZs). METHODS: A total of 42 consecutive patients with focal epilepsy were enrolled. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of visually assessed RS-fMRI, MRI, magnetic resonance spectroscopy (MRS), video electroencephalography (VEEG), and positron-emission tomography computed tomography (PET-CT) in EZ localization were evaluated to assess their diagnostic abilities...
2017: PloS One
https://www.readbyqxmd.com/read/28195438/from-rest-to-language-task-task-activation-selects-and-prunes-from-broader-resting-state-network
#4
Gaelle E Doucet, Xiaosong He, Michael R Sperling, Ashwini Sharan, Joseph I Tracy
Resting-state networks (RSNs) show spatial patterns generally consistent with networks revealed during cognitive tasks. However, the exact degree of overlap between these networks has not been clearly quantified. Such an investigation shows promise for decoding altered functional connectivity (FC) related to abnormal language functioning in clinical populations such as temporal lobe epilepsy (TLE). In this context, we investigated the network configurations during a language task and during resting state using FC...
February 14, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28194612/simultaneous-intracranial-eeg-fmri-shows-inter-modality-correlation-in-time-resolved-connectivity-within-normal-areas-but-not-within-epileptic-regions
#5
Ben Ridley, Jonathan Wirsich, Gaelle Bettus, Roman Rodionov, Teresa Murta, Umair Chaudhary, David Carmichael, Rachel Thornton, Serge Vulliemoz, Andrew McEvoy, Fabrice Wendling, Fabrice Bartolomei, Jean-Philippe Ranjeva, Louis Lemieux, Maxime Guye
For the first time in research in humans, we used simultaneous icEEG-fMRI to examine the link between connectivity in haemodynamic signals during the resting-state (rs) and connectivity derived from electrophysiological activity in terms of the inter-modal connectivity correlation (IMCC). We quantified IMCC in nine patients with drug-resistant epilepsy (i) within brain networks in 'healthy' non-involved cortical zones (NIZ) and (ii) within brain networks involved in generating seizures and interictal spikes (IZ1) or solely spikes (IZ2)...
February 13, 2017: Brain Topography
https://www.readbyqxmd.com/read/28180076/face-name-association-task-reveals-memory-networks-in-patients-with-left-and-right-hippocampal-sclerosis
#6
Silke Klamer, Monika Milian, Michael Erb, Sabine Rona, Holger Lerche, Thomas Ethofer
We aimed to identify reorganization processes of episodic memory networks in patients with left and right temporal lobe epilepsy (TLE) due to hippocampal sclerosis as well as their relations to neuropsychological memory performance. We investigated 28 healthy subjects, 12 patients with left TLE (LTLE) and 9 patients with right TLE (RTLE) with hippocampal sclerosis by means of functional magnetic resonance imaging (fMRI) using a face-name association task, which combines verbal and non-verbal memory functions...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28180072/the-diminishing-dominance-of-the-dominant-hemisphere-language-fmri-in-focal-epilepsy
#7
Chris Tailby, David F Abbott, Graeme D Jackson
"Which is the dominant hemisphere?" is a question that arises frequently in patients considered for neurosurgery. The concept of the dominant hemisphere implies uniformity of language lateralisation throughout the brain. It is increasingly recognised that this is not the case in the healthy control brain, and it is especially not so in neurological diseases such as epilepsy. In the present work we adapt our published objective lateralisation method (based on the construction of laterality curves) for use with sub-lobar cortical, subcortical and cerebellar regions of interest (ROIs)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28160753/lateralization-of-language-function-in-epilepsy-patients-a-high-density-scalp-derived-event-related-potentials-erp-study
#8
Karin Trimmel, Jens Sachsenweger, Gerald Lindinger, Eduard Auff, Fritz Zimprich, Ekaterina Pataraia
OBJECTIVES: Language functional magnetic resonance imaging (fMRI) represents the clinical standard for language lateralization assessment in presurgical epilepsy evaluation, but still many patients experience postoperative language deficits. Event-related potentials (ERPs), especially the negative component around and after 400ms, are related to language processing and could therefore represent a complementary method of language lateralization assessment. METHODS: Scalp EEG was recorded from 64 locations in 36 epilepsy patients and 37 controls during three visually presented language tasks: A short-term language memory task (differentiation memorized vs...
January 12, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28131205/altered-degree-centrality-in-childhood-absence-epilepsy-a-resting-state-fmri-study
#9
Xueyu Wang, Dongmei Jiao, Xinying Zhang, Xiangtao Lin
Modern network studies have suggested that the pathology of many neurological diseases is in fact not equally distributed over the brain but preferentially affects the hub regions. This study aims to investigate how hub regions were affected in Children with Childhood absence epilepsy (CAE) using resting-state fMRI (rs-fMRI). As one important measures obtained from rs-fMRI, degree centrality (DC) calculates the number of direct connections between a given node and the rest of the brain within the entire connectivity matrix of the brain...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28123951/large-scale-cortico-subcortical-functional-networks-in-focal-epilepsies-the-role-of-the-basal-ganglia
#10
Eva Výtvarová, Radek Mareček, Jan Fousek, Ondřej Strýček, Ivan Rektor
OBJECTIVES: The aim was to describe the contribution of basal ganglia (BG) thalamo-cortical circuitry to the whole-brain functional connectivity in focal epilepsies. METHODS: Interictal resting-state fMRI recordings were acquired in 46 persons with focal epilepsies. Of these 46, 22 had temporal lobe epilepsy: 9 left temporal (LTLE), 13 right temporal (RTLE); 15 had frontal lobe epilepsy (FLE); and 9 had parietal/occipital lobe epilepsy (POLE). There were 20 healthy controls...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28116237/brain-correlates-of-spike-and-wave-discharges-in-glut1-deficiency-syndrome
#11
Anna Elisabetta Vaudano, Sara Olivotto, Andrea Ruggieri, Giuliana Gessaroli, Valentina De Giorgis, Antonia Parmeggiani, Pierangelo Veggiotti, Stefano Meletti
PURPOSE: To provide imaging biomarkers of generalized spike-and-wave discharges (GSWD) in patients with GLUT1 deficiency syndrome (GLUT1DS). METHODS: Eighteen GLUT1DS patients with pathogenetic mutation in SLC2A1 gene were studied by means of Video-EEG simultaneously recorded with functional MRI (VideoEEG-fMRI). A control group of sex and age-matched patients affected by Genetic Generalized Epilepsy (GGE) with GSWD were investigated with the same protocol. Within and between groups comparison was performed as appropriated...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28109990/ictal-eeg-fmri-study-of-vertiginous-seizures
#12
Alessandra Morano, Marco Carnì, Sara Casciato, Anna Elisabetta Vaudano, Jinane Fattouch, Martina Fanella, Mariarita Albini, Luca Manfredi Basili, Giulia Lucignani, Marco Scapeccia, Regina Tomassi, Elisabetta Di Castro, Claudio Colonnese, Anna Teresa Giallonardo, Carlo Di Bonaventura
Vertigo and dizziness are extremely common complaints, related to either peripheral or central nervous system disorders. Among the latter, epilepsy has to be taken into consideration: indeed, vertigo may be part of the initial aura of a focal epileptic seizure in association with other signs/symptoms, or represent the only ictal manifestation, a rare phenomenon known as "vertiginous" or "vestibular" seizure. These ictal symptoms are usually related to a discharge arising from/involving temporal or parietal areas, which are supposed to be a crucial component of the so-called "vestibular cortex"...
January 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28104639/hippocampal-atrophy-is-associated-with-altered-hippocampus-posterior-cingulate-cortex-connectivity-in-mesial-temporal-lobe-epilepsy-with-hippocampal-sclerosis
#13
Y C Shih, C E Tseng, F-H Lin, H H Liou, W Y I Tseng
BACKGROUND AND PURPOSE: Unilateral mesial temporal lobe epilepsy and hippocampal sclerosis have structural and functional abnormalities in the mesial temporal regions. To gain insight into the pathophysiology of the epileptic network in mesial temporal lobe epilepsy with hippocampal sclerosis, we aimed to clarify the relationships between hippocampal atrophy and the altered connection between the hippocampus and the posterior cingulate cortex in patients with mesial temporal lobe epilepsy with hippocampal sclerosis...
January 19, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28104438/safety-of-externally-stimulated-intracranial-electrodes-during-functional-mri-at-1-5t
#14
Pallab K Bhattacharyya, Jeffery Mullin, Bryan S Lee, Jorge A Gonzalez-Martinez, Stephen E Jones
Surgical resection of the epileptogenic zone (EZ) is a potential cure for medically refractory focal epilepsy. Proper identification of the EZ is essential for such resection. Synergistic application of functional magnetic resonance imaging (fMRI) simultaneously with stimulation of a single externalized intracranial stereotactic EEG (SEEG) electrode has the potential to improve identification of the EZ. While most EEG-fMRI studies use the electrodes passively to record electrical activity, it is possible to stimulate the brain using the electrodes by connecting them with conducting cables to the stimulation hardware...
January 16, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28104084/access-to-vagal-projections-via-cutaneous-electrical-stimulation-of-the-neck-fmri-evidence-in-healthy-humans
#15
Eleni Frangos, Barry R Komisaruk
BACKGROUND: Stimulation of the vagus nerve via implanted electrodes is currently used to treat refractory epilepsy and depression. Recently, a non-invasive approach to vagal stimulation has demonstrated similar beneficial effects, but it remains unclear whether these effects are mediated via activation of afferent vagal fibers. OBJECTIVE: The present study was designed to ascertain whether afferent vagal projections can be accessed non-invasively by transcutaneous electrical stimulation of the antero-lateral surface of the neck, which overlies the course of the vagus nerve...
January 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28077494/practice-guideline-summary-use-of-fmri-in-the-presurgical-evaluation-of-patients-with-epilepsy-report-of-the-guideline-development-dissemination-and-implementation-subcommittee-of-the-american-academy-of-neurology
#16
Jerzy P Szaflarski, David Gloss, Jeffrey R Binder, William D Gaillard, Alexandra J Golby, Scott K Holland, Jeffrey Ojemann, David C Spencer, Sara J Swanson, Jacqueline A French, William H Theodore
OBJECTIVE: To assess the diagnostic accuracy and prognostic value of functional MRI (fMRI) in determining lateralization and predicting postsurgical language and memory outcomes. METHODS: An 11-member panel evaluated and rated available evidence according to the 2004 American Academy of Neurology process. At least 2 panelists reviewed the full text of 172 articles and selected 37 for data extraction. Case reports, reports with <15 cases, meta-analyses, and editorials were excluded...
January 24, 2017: Neurology
https://www.readbyqxmd.com/read/28018680/distinctive-structural-and-effective-connectivity-changes-of-semantic-cognition-network-across-left-and-right-mesial-temporal-lobe-epilepsy-patients
#17
Xiaotong Fan, Hao Yan, Yi Shan, Kun Shang, Xiaocui Wang, Peipei Wang, Yongzhi Shan, Jie Lu, Guoguang Zhao
Occurrence of language impairment in mesial temporal lobe epilepsy (mTLE) patients is common and left mTLE patients always exhibit a primary problem with access to names. To explore different neuropsychological profiles between left and right mTLE patients, the study investigated both structural and effective functional connectivity changes within the semantic cognition network between these two groups and those from normal controls. We found that gray matter atrophy of left mTLE patients was more severe than that of right mTLE patients in the whole brain and especially within the semantic cognition network in their contralateral hemisphere...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/28017580/functional-mri-based-connectivity-analysis-a-promising-tool-for-the-investigation-of-the-pathophysiology-and-comorbidity-of-epilepsy
#18
Fenglai Xiao, Dongmei An, Dong Zhou
Epilepsy has been recognized as a brain network disorder. Therefore, functional MRI (fMRI)-based connectivity is an ideal technique for exploring the complex effects of epilepsy on the brain. Functional connectivity studies have provided insights into the physiopathogenesis of the epileptic network underlying focal epilepsies, genetic generalized epilepsy, and specific epileptic syndromes. An increasing number of studies have focused on the deleterious effects of epilepsy on other brain networks to help to explain cognitive deficits and psychiatric symptoms...
October 14, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28017196/relationship-between-resting-state-functional-magnetic-resonance-imaging-and-memory-function-in-mesial-temporal-lobe-epilepsy
#19
Shenggen Chen, Lin Chen, Huapin Huang, Wanhui Lin
OBJECT: To study memory impairment mechanisms of the medial temporal lobe epilepsy (MTLE) by analyzing the functional connectivity (FC) through resting state functional magnetic resonance imaging (rs-fMRI). METHODS: Rs-fMRI data were acquired from 13 patients with left MTLE and 11 patients with right MTLE. Another 13 healthy volunteers were selected as controls. The altered FC pattern between the unilateral hippocampus and other regions of the brain in MTLE patients was compared to that of the normal control group...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28003958/metrics-of-brain-network-architecture-capture-the-impact-of-disease-in-children-with-epilepsy
#20
Michael J Paldino, Wei Zhang, Zili D Chu, Farahnaz Golriz
BACKGROUND AND OBJECTIVE: Epilepsy is associated with alterations in the structural framework of the cerebral network. The aim of this study was to measure the potential of global metrics of network architecture derived from resting state functional MRI to capture the impact of epilepsy on the developing brain. METHODS: Pediatric patients were retrospectively identified with: 1. Focal epilepsy; 2. Brain MRI at 3 Tesla, including resting state functional MRI; 3. Full scale IQ measured by a pediatric neuropsychologist...
2017: NeuroImage: Clinical
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