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https://www.readbyqxmd.com/read/29606553/new-and-emerging-technologies-in-treatment-of-lower-urinary-tract-symptoms-from-benign-prostatic-hyperplasia
#1
REVIEW
Nikhil K Gupta, Steven N Gange, Kevin T McVary
INTRODUCTION: Lower urinary tract symptoms (LUTS) from bladder outlet obstruction from benign prostatic hyperplasia (BPH) occur in a large percentage of urologic patients. Treatment of this condition with medical and surgical therapy provides symptom relief but has serious adverse effects and causes sexual dysfunction. New technologies to treat BPH-associated LUTS aim to effectively treat urinary symptoms and minimize side effects and sexual dysfunction. AIM: To review the efficacy of new and emerging therapies for treatment of LUTS from BPH...
March 29, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29530631/what-s-new-in-rez%C3%A5-m
#2
REVIEW
Piyush Pathak, Sevann Helo, Kevin T McVary
Management of benign prostatic hyperplasia focuses on relief of lower urinary tract symptoms (LUTSs), improvement of quality of life, and prevention of symptom progression. Minimally invasive surgical treatments (MISTs) offer potential for rapid symptomatic relief, medication independence, and less perioperative risk. The Rezūm system is a novel MIST that uses water vapor thermal therapy to ablate obstructive prostate tissue. In this review, we summarize the data revealing that water vapor thermal therapy provides clinically meaningful, rapid, and durable relief of LUTSs in both storage and voiding functions while providing a minimal impact on sexual function...
March 9, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29499208/3-year-treatment-outcomes-of-water-vapor-thermal-therapy-rez%C3%A5-m-system-compared-to-doxazosin-finasteride-and-combination-drug-therapy-for-men-with-benign-prostatic-hyperplasia-cohort-data-from-the-medical-therapy-of-prostatic-symptoms-mtops-trial
#3
Nikhil Gupta, Tyson Rogers, Bradley Holland, Sevann Helo, Danuta Dynda, Kevin T McVary
PURPOSE: This evaluation of long-term outcomes of treatment for lower urinary tract symptoms due to benign prostatic hyperplasia compares a one-time water vapor thermal therapy procedure with daily medical therapy in cohorts from the Medical Therapy of Prostatic Symptoms (MTOPS) study. MATERIALS AND METHODS: Results from the treatment arm of a randomized, controlled trial of thermal therapy (Rezūm System) were compared to MTOPS subjects treated with doxazosin, finasteride, or both...
February 27, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29352666/handling-processing-and-disposal-of-stem-cell-products-in-europe-a-survey-by-the-cellular-therapy-and-immunobiology-working-party-of-the-european-society-for-blood-and-marrow-transplantation
#4
Andreas Holbro, Helen Baldomero, Francesco Lanza, Christian Chabannon, John A Snowden, Andreas Buser, Laura Infanti, Nina Worel, Anna Sureda, Manuela Badoglio, Jakob Passweg, Chiara Bonini
BACKGROUND: There is considerable heterogeneity in processing of stem cells for hematopoietic stem cell transplantation across Europe. The Foundation for the Accreditation of Cellular Therapy (FACT)-Joint Accreditation Committee International Society for Cellular Therapy and European Society for Blood and Marrow Transplantation (EBMT) (JACIE) standards provide minimum guidelines that, however, leave room for significant variations in practices at the individual transplantation center (TC)...
March 2018: Cytotherapy
https://www.readbyqxmd.com/read/29343977/cost-effectiveness-analysis-of-six-therapies-for-the-treatment-of-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia
#5
James C Ulchaker, Melissa S Martinson
Objective: To conduct a cost-effectiveness analysis from payers' perspectives of six treatments for lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) and to examine positioning of these modalities in the marketplace for the best use of health care funds and quality-of-life benefits for patients. Methods: The economic analysis was conducted with a Markov model to compare combination prescription drug therapy (ComboRx), minimally invasive therapies (MITs) including convective radiofrequency (RF) water vapor thermal therapy (Rezūm®), conductive RF thermal therapy (Prostiva®), and prostatic urethral lift (UroLift®), and invasive surgical procedures including photovaporization of the prostate (Greenlight® PVP) and transurethral resection of the prostate (TURP)...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29282358/convective-radiofrequency-water-vapor-thermal-therapy-for-benign-prostatic-hyperplasia-a-single-office-experience
#6
Daniel Mollengarden, Kenneth Goldberg, Daniel Wong, Claus Roehrborn
BACKGROUND: Convective radiofrequency water vapor thermal therapy with the Rezūm system is a relatively new treatment for benign prostatic hyperplasia (BPH). We present results from a single surgeon in an office setting. METHODS: A retrospective review of 129 patients from a single surgeon who underwent the Rezūm procedure was performed. All patients were at least 4 months out from treatment. International prostate symptom scores (IPSS), maximum flow rates (Qmax), residual urine volumes, medication usage, and adverse events were monitored...
December 27, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29122620/three-year-outcomes-of-the-prospective-randomized-controlled-rez%C3%A5-m-system-study-convective-radiofrequency-thermal-therapy-for-treatment-of-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia
#7
Kevin T McVary, Claus G Roehrborn
OBJECTIVE: To report 3-year outcomes of a prospective, multicenter, randomized, blinded control trial after treatment with convective radiofrequency (RF) water vapor thermal therapy for moderate to severe lower urinary tract symptoms due to benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: Fifteen centers enrolled and randomized 197 men ≥50 years old with International Prostate Symptom Score (IPSS) ≥13, maximum flow rate (Qmax) ≤15 mL/s, and prostate volume 30 to 80 cc to thermal therapy with Rezūm System or control (2:1)...
January 2018: Urology
https://www.readbyqxmd.com/read/28877412/neuronal-differentiation-of-human-mesenchymal-stem-cells-in-response-to-the-domain-size-of-graphene-substrates
#8
Yoo-Jung Lee, Tae Hoon Seo, Seula Lee, Wonhee Jang, Myung Jong Kim, Jung-Suk Sung
Graphene is a noncytotoxic monolayer platform with unique physical, chemical, and biological properties. It has been demonstrated that graphene substrate may provide a promising biocompatible scaffold for stem cell therapy. Because chemical vapor deposited graphene has a two dimensional polycrystalline structure, it is important to control the individual domain size to obtain desirable properties for nano-material. However, the biological effects mediated by differences in domain size of graphene have not yet been reported...
January 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28861405/procedural-techniques-and-multicenter-postmarket-experience-using-minimally-invasive-convective-radiofrequency-thermal-therapy-with-rez%C3%A5-m-system-for-treatment-of-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia
#9
Micheal F Darson, Erik E Alexander, Zvi J Schiffman, Michael Lewitton, Robert A Light, Mark A Sutton, Carlos Delgado-Rodriguez, Ricardo R Gonzalez
OBJECTIVE: This report evaluates clinical experience with the Rezūm system after US Food and Drug Administration clearance in consecutive cases accrued by multiple community urologists for the treatment of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Treatment techniques for transurethral convective radiofrequency water-vapor thermal therapy and outcomes with up to 12 months' follow-up are presented. MATERIALS AND METHODS: A total of 131 patients with moderate-severe LUTS were included in a retrospective analysis of BPH procedures with the Rezūm system...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28780635/convective-radiofrequency-water-vapor-thermal-therapy-with-rez%C3%A5-m-system
#10
REVIEW
Sevann Helo, Bradley Holland, Kevin T McVary
PURPOSE: Lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) are amongst the most commonly treated conditions by urologists. Minimally invasive therapies for the treatment of BPH/LUTS have garnered increased interest as new technology has emerged, improving durability, efficacy, and safety. This paper reviews the most recent literature regarding water vapor therapy, a convective thermal therapy that ablates prostatic tissue. RECENT FINDINGS: The current literature includes a pilot study of 65 men and a randomized controlled trial (RCT) of 197 men investigating the efficacy and safety profile of water vapor therapy up to 2 years...
October 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28490907/perspective-on-the-rez%C3%A5-m-%C3%A2-system-a-minimally-invasive-treatment-strategy-for-benign-prostatic-hyperplasia-using-convective-radiofrequency-water-vapor-thermal-therapy
#11
Henry H Woo, Ricardo R Gonzalez
Convective radiofrequency (RF) water vapor thermal therapy is a minimally invasive office or outpatient procedure for the treatment of bothersome moderate-to-severe lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH). It provides an option for patients seeking rapid and durable relief of urinary symptoms, improved quality of life, and preservation of sexual function as an alternative to long-term use of drugs and avoidance of the potential side effects of pharmaceuticals or invasive BPH surgery...
2017: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/28450246/hypericum-perforatum-incorporated-chitosan-films-as-potential-bioactive-wound-dressing-material
#12
Seda Güneş, Funda Tıhmınlıoğlu
Recent studies in wound dressing applications offer new therapies and promote wound healing process. The aim of this study was to develop Hypericum perforatum (St John's Wort) oil incorporated chitosan films for wound dressing applications. H. perforatum oil as a potential therapeutic agent was encapsulated in chitosan film to achieve a better wound dressing material. Oil incorporated chitosan films were successfully prepared by solvent casting method in different oil concentrations (0.25-1.5%v/v). Water vapor permeability (WVP), mechanical test, swelling behavior and surface hydrophobicity were performed in order to characterize the prepared films...
September 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28378308/current-advancements-of-magnetic-nanoparticles-in-adsorption-and-degradation-of-organic-pollutants
#13
Mazhar Ul-Islam, Muhammad Wajid Ullah, Shaukat Khan, Shehrish Manan, Waleed Ahmad Khattak, Wasi Ahmad, Nasrullah Shah, Joong Kon Park
Nanotechnology is a fast-emerging field and has received applications in almost every field of life. Exploration of new synthetic technologies for size and shape control of nanomaterials is getting immense consideration owing to their exceptional properties and applications. Magnetic nanoparticles (MNPs) are among the most important group of nanoparticles thanks to their diverse applications in medical, electronic, environmental, and industrial sectors. There have been numerous synthetic routes of MNPs including thermal decomposition, co-precipitation, microemulsion, microwave assisted, chemical vapor deposition, combustion synthesis, and laser pyrolysis synthesis...
May 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28088847/vapor-and-gas-bubble-growth-dynamics-around-laser-irradiated-water-immersed-plasmonic-nanoparticles
#14
Yuliang Wang, Mikhail E Zaytsev, Hai Le The, Jan C T Eijkel, Harold J W Zandvliet, Xuehua Zhang, Detlef Lohse
Microbubbles produced by exposing water-immersed metallic nanoparticles to resonant light play an important role in emerging and efficient plasmonic-enhanced processes for catalytic conversion, solar energy harvesting, biomedical imaging, and cancer therapy. How do these bubbles form, and what is their gas composition? In this paper, the growth dynamics of nucleating bubbles around laser-irradiated, water-immersed Au plasmonic nanoparticles are studied to determine the exact origin of the occurrence and growth of these bubbles...
February 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/27993667/convective-thermal-therapy-durable-2-year-results-of-randomized-controlled-and-prospective-crossover-studies-for-treatment-of-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia
#15
Claus G Roehrborn, Steven N Gange, Marc C Gittelman, Kenneth A Goldberg, Kalpesh Patel, Neal D Shore, Richard M Levin, Michael Rousseau, J Randolf Beahrs, Jed Kaminetsky, Barrett E Cowan, Christopher H Cantrill, Lance A Mynderse, James C Ulchaker, Thayne R Larson, Christopher M Dixon, Kevin T McVary
PURPOSE: We report 2-year outcomes of a multicenter randomized controlled trial plus 1-year results of a crossover trial after treatment with convective radiofrequency water vapor thermal energy for lower urinary tract symptoms due to benign prostatic hyperplasia. MATERIALS AND METHODS: A total of 197 men at least 50 years old with I-PSS (International Prostate Symptom Score) 13 or greater, maximum flow rate 15 ml per second or less and prostate size 30 to 80 cc were randomized 2:1 to thermal therapy with the Rezūm® System or a control group...
June 2017: Journal of Urology
https://www.readbyqxmd.com/read/27921028/two-year-results-after-convective-radiofrequency-water-vapor-thermal-therapy-of-symptomatic-benign-prostatic-hyperplasia
#16
Christopher M Dixon, Edwin Rijo Cedano, Dalibor Pacik, Vítězslav Vit, Gabriel Varga, Lennart Wagrell, Thayne R Larson, Lance A Mynderse
OBJECTIVE: The objective of this study was to assess the effectiveness and safety of convective radiofrequency (RF) water vapor thermal therapy in men with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH); a pilot study design with 2-year follow-up evaluations. PATIENTS AND METHODS: Men aged ≥45 years with an International Prostate Symptom Score ≥13, a maximum urinary flow rate (Qmax) ≤15 mL/s, and prostate volume 20-120 cc were enrolled in a prospective, open-label pilot study using convective RF water vapor energy with the Rezūm System...
2016: Research and Reports in Urology
https://www.readbyqxmd.com/read/27647149/controlled-evacuation-using-the-biocompatible-and-energy-efficient-microfluidic-ejector
#17
V N Lad, Swati Ralekar
Development of controlled vacuum is having many applications in the realm of biotechnology, cell transfer, gene therapy, biomedical engineering and other engineering activities involving separation or chemical reactions. Here we show the controlled vacuum generation through a biocompatible, energy efficient, low-cost and flexible miniature device. We have designed and fabricated microfluidic devices from polydimethylsiloxane which are capable of producing vacuum at a highly controlled rate by using water as a motive fluid...
October 2016: Biomedical Microdevices
https://www.readbyqxmd.com/read/27416660/-minimally-invasive-techniques-in-the-treatment-of-benign-prostatic-hyperplasia-an-update
#18
REVIEW
Yi-ping Lu, Jia-yu Liang
Lower urinary tract symptoms (LUTS) resulting from benign prostatic hyperplasia (BPH) obviously impair the quality of life of middle-aged and elderly men. Current management of BPH includes wait-and-watch, medical therapy, and conventional surgery. As a new approach, minimally invasive surgery has been playing an increasingly important role in the management of BPH, with potential advantages of less operative trauma, quicker recovery, lower risk of postoperative complications and higher quality of life. This review mainly discusses prostatic urethral lift (Urolift® System), transurethral water vapor therapy (Rezūm® System) and robot-guided high-energy water ablation (PROCEPT Aquablation™ System)...
May 2016: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/27240752/comparison-of-the-properties-of-membranes-produced-with-alginate-and-chitosan-from-mushroom-and-from-shrimp
#19
COMPARATIVE STUDY
Andréa C K Bierhalz, Cecília Buzatto Westin, Ângela Maria Moraes
Dense and porous chitosan-alginate membranes (1:1 in mass) useful as coverages of skin wounds treated through cell therapy were produced using chitosan of different chain sizes from fungal (white mushrooms) and animal (shrimp shells) sources. Porous materials were obtained by adding the surfactant Poloxamer 188 to the formulations. The influence of chitosan type on membranes physicochemical properties and toxicity to fibroblasts was evaluated. Porosity was noticed to be more pronounced in membranes obtained with fungal chitosan and increased with its molecular mass...
October 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27129767/erectile-and-ejaculatory-function-preserved-with-convective-water-vapor-energy-treatment-of-lower-urinary-tract-symptoms-secondary-to-benign-prostatic-hyperplasia-randomized-controlled-study
#20
RANDOMIZED CONTROLLED TRIAL
Kevin T McVary, Steven N Gange, Marc C Gittelman, Kenneth A Goldberg, Kalpesh Patel, Neal D Shore, Richard M Levin, Michael Rousseau, J Randolf Beahrs, Jed Kaminetsky, Barrett E Cowan, Christopher H Cantrill, Lance A Mynderse, James C Ulchaker, Thayne R Larson, Christopher M Dixon, Claus G Roehrborn
INTRODUCTION: Most surgical treatments for male lower urinary tract symptoms and benign prostatic hyperplasia affect erectile and ejaculatory functions negatively, leading to patient dissatisfaction. AIM: To determine whether water vapor thermal therapy, when conducted in a randomized controlled trial, would significantly improve lower urinary tract symptoms secondary to benign prostatic hyperplasia and urinary flow rate while preserving erectile and ejaculatory functions...
June 2016: Journal of Sexual Medicine
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