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https://www.readbyqxmd.com/read/27913463/single-dose-intravenous-iron-for-iron-deficiency-a-new-paradigm
#1
Michael Auerbach, Thomas Deloughery
Iron-deficiency anemia is the most common hematologic problem in the world. Although oral iron is often viewed as front-line therapy, extensive published evidence has accumulated that IV iron is superior, in both efficacy and safety, to oral iron in many clinical situations and should be introduced much sooner in the treatment paradigm of iron-deficient patients. In this chapter, we will review the formulations of IV iron that allow total complete replacement doses in 1 or 2 sessions including practical tips for administration...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27890816/pathophysiology-of-hemophilic-arthropathy-and-potential-targets-for-therapy
#2
REVIEW
Astrid E Pulles, Simon C Mastbergen, Roger E G Schutgens, Floris P J G Lafeber, Lize F D van Vulpen
Hemophilia is a congenital clotting factor deficiency characterized by spontaneous and trauma-related bleeding. Spontaneous bleeding shows a predilection for joints, and repeated hemarthroses lead to a disabling condition called hemophilic arthropathy. Treatment of this condition consists of preventing joint bleeding on the one hand and orthopedic surgery as a last resort on the other. Up till now, there is no disease modifying therapy available to fill the gap between these extremes. This review provides an overview of the pathogenesis of hemophilic arthropathy in order to identify potential targets for therapy...
November 24, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27885534/zinc-deficiency-after-gastric-bypass-for-morbid-obesity-a-systematic-review
#3
REVIEW
Kamal K Mahawar, Aparna Govil Bhasker, Vivek Bindal, Yitka Graham, Usha Dudeja, Muffazal Lakdawala, Peter K Small
Up to 50% of patients have zinc deficiency before bariatric surgery. Roux-en-Y gastric bypass (RYGB) is the commonest bariatric procedure worldwide. It can further exacerbate zinc deficiency by reducing intake as well as absorption. The British Obesity and Metabolic Surgery Society, therefore, recommends that zinc level should be monitored routinely following gastric bypass. However, the American guidance does not recommend such monitoring for all RYGB patients and reserves it for patients with 'specific findings'...
November 24, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27798793/weight-regain-10%C3%A2-years-after-roux-en-y-gastric-bypass
#4
Daniela Vicinansa Monaco-Ferreira, Vânia Aparecida Leandro-Merhi
OBJECTIVE: This study aims to investigate weight regain and the associated variables 10 years after Roux-en-Y gastric bypass. METHOD: This retrospective study recruited patients submitted to Roux-en-Y gastric bypass (N = 166) for a 10-year follow-up. The following variables were investigated: body mass index (BMI), percentage of excess weight loss (%EWL), weight regain (WR), and percentage of weight regain (%WG). The chi-squared test or Fisher's exact test compared proportions, and the Mann-Whitney test compared numerical measurements between the groups...
October 31, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27695053/presence-of-serum-ferritin-before-and-after-bariatric-surgery-analysis-in-dentate-and-edentulous-patients
#5
Gerson Aparecido Foratori, Francisco Juliherme Pires de Andrade, Victor Mosquim, Matheus de Carvalho Sales Peres, Reginaldo Ceneviva, Elinton Adami Chaim, Silvia Helena de Carvalho Sales Peres
Society has changed its own lifestyle, specially its eating habits and physical activities, leading to excessive weight and a sedentary behavior, which has contributed to obesity increase. Bariatric surgery is the most effective treatment to obesity, allowing weight loss and its maintenance. However, it has been related high levels of iron deficiency after surgery. A person's nutritional status might be affected by total or partial tooth loss. The aim of this longitudinal prospective cohort study was to evaluate the levels of serum ferritin before and after bariatric surgery and to identify if there is a relation with tooth loss...
2016: PloS One
https://www.readbyqxmd.com/read/27683780/pre-and-postoperative-in-bariatric-surgery-some-biochemical-changes
#6
Amanda Kaseker Tedesco, Rafaela Biazotto, Telma Souza E Silva Gebara, Maria Paula Carlini Cambi, Giorgio Alfredo Pedroso Baretta
Background: The bariatric surgery may cause some nutritional deficiencies. Aim: To compare the serum levels of biochemical markers, in iimmediate post-surgical patients who were submitted to bariatric surgery. Methods: Non-concurrent prospective cross-sectional study. The analysis investigated data in medical charts of pre-surgical and immediate post-surgical patients who were submitted to bariatric surgery, focusing total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, C reactive protein, vitamin B12 levels, folic acid, homocysteine values, iron and serum calcium at the referred period...
2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27683779/serum-vitamin-b12-iron-and-folic-acid-deficiencies-in-obese-individuals-submitted-to-different-bariatric-techniques
#7
Rafaella de Andrade Silva, Flávia Monteiro França Malta, Maria Flora Ferreira Sampaio Carvalho Correia, Maria Goretti Pessoa de Araújo Burgos
Background: Different surgical techniques to combat obesity combine malabsorption with restrictive procedures and can lead to metabolic problems, such as micronutrient deficiencies. Aim: Assess vitamin B12, iron and folic acid deficiencies associated with the lifestyle of obese individuals having been submitted to different bariatric techniques. Methods: A retrospective analysis was performed using the electronic charts of patients submitted to bariatric surgery involving adjustable gastric banding and Roux-en-Y gastric bypass at the São João Hospital Center in the city of Porto, Portugal, between 2005 and 2010...
2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27643771/case-234-neuropathic-spondyloarthropathy
#8
Ramez R Hanna, Nicholas Kolanko, Carlos Torres
History A 70-year-old woman presented to a peripheral hospital with signs and symptoms of acute chronic obstructive pulmonary disease (COPD) exacerbation. The patient also reported acute on chronic onset of thoracolumbar back pain over a period of 24 hours. She denied any history of recent trauma or intravenous drug use. She did not have any long-term indwelling catheters. The patient's medical history was also complicated by stage 4 renal failure from long-standing type II diabetes, hypertension, iron deficiency anemia, aortic stenosis, and prior bariatric surgery...
October 2016: Radiology
https://www.readbyqxmd.com/read/27570088/intravenous-ferric-carboxymaltose-versus-standard-care-in-the-management-of-postoperative-anaemia-a-prospective-open-label-randomised-controlled-trial
#9
Alhossain A Khalafallah, Carl Yan, Raghad Al-Badri, Ella Robinson, Brooke E Kirkby, Emily Ingram, Zara Gray, Vinod Khelgi, Iain K Robertson, Brian P Kirkby
BACKGROUND: Despite increasing efforts in perioperative management, postoperative iron deficiency anaemia persists, and few data are available about the management of this condition. In this study, we aimed to determine whether giving postoperative intravenous iron (in the form of ferric carboxymaltose) improved iron stores, haemoglobin concentrations, and outcomes following surgery. METHODS: We did a prospective, open-label, randomised, controlled study of patients at two centres (a general hospital and a private health-care centre) in Tasmania, Australia, undergoing elective surgery with functional iron deficiency anaemia (haemoglobin 70-120 g/L and ferritin ≤100 μg/L or iron saturation ≤20%), measured at day 1 postoperatively...
September 2016: Lancet Haematology
https://www.readbyqxmd.com/read/27557657/the-effects-of-fat-loss-after-bariatric-surgery-on-inflammation-serum-hepcidin-and-iron-absorption-a-prospective-6-mo-iron-stable-isotope-study
#10
Ana C Cepeda-Lopez, Javier Allende-Labastida, Alida Melse-Boonstra, Saskia Jm Osendarp, Isabelle Herter-Aeberli, Diego Moretti, Ramiro Rodriguez-Lastra, Francisco Gonzalez-Salazar, Salvador Villalpando, Michael B Zimmermann
BACKGROUND: Iron deficiency is common in obese subjects. This may be due to an increase in serum hepcidin and a decrease in iron absorption from adiposity-related inflammation. OBJECTIVE: We evaluated whether weight and fat loss in obese subjects would decrease inflammation and serum hepcidin and thereby improve iron absorption. DESIGN: We performed a 6-mo prospective study in obese [body mass index (in kg/m(2)) ≥35 and <45] adults who had recently undergone laparoscopic sleeve gastrectomy...
October 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27426696/pregnancy-and-perinatal-outcomes-according-to-surgery-to-conception-interval-and-gestational-weight-gain-in-women-with-previous-gastric-bypass
#11
Louise Laage Stentebjerg, Lise Lotte Torvin Andersen, Kristina Renault, René Klinkby Støving, Dorte Møller Jensen
OBJECTIVE: To compare perinatal and pregnancy outcomes including adherence to the Institute of Medicine's (IOM) recommendations for gestational weight gain (GWG) in pregnant women with conception <18 months (early group) compared to ≥18 months following gastric bypass (late group). METHODS: Retrospective cohort study comprising 71 women with gastric bypass and a singleton pregnancy presenting at Odense University Hospital, November 2007-October 2013. Data were extracted from medical records and laboratory systems...
July 17, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27403412/nutrition-in-patients-with-gastric-cancer-an-update
#12
REVIEW
Rosa Rosania, Costanza Chiapponi, Peter Malfertheiner, Marino Venerito
BACKGROUND: Nutritional management of patients with gastric cancer (GC) represents a challenge. SUMMARY: This review provides an overview of the present evidence on nutritional support in patients with GC undergoing surgery as well as in those with advanced disease. KEY MESSAGE: For patients undergoing surgery, the preoperative nutritional condition directly affects postoperative prognosis, overall survival and disease-specific survival. Perioperative nutritional support enriched with immune-stimulating nutrients reduces overall complications and hospital stay but not mortality after major elective gastrointestinal surgery...
May 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27379280/transfusion-dependent-anaemia-an-overlooked-complication-of-paraoesophageal-hernias
#13
Richard J E Skipworth, Ralph F Staerkle, Steven Leibman, Garett S Smith
Introduction. A paraoesophageal hernia (PH) may be one reason for iron-deficiency anaemia (IDA) but is often overlooked as a cause. We aimed to assess the incidence and resolution of transfusion-dependent IDA in patients presenting for hiatal hernia surgery. Methods. We analysed a prospective database of patients undergoing laparoscopic hiatal repair in order to identify patients with severe IDA requiring red cell/iron transfusion. Results. Of 138 patients with PH managed over a 4-year period, 7 patients (5...
2014: International Scholarly Research Notices
https://www.readbyqxmd.com/read/27277557/-nutritional-deficiencies-and-supplementation-after-metabolic-surgery
#14
C Stroh, F Meyer, T Manger
Increasing prevalence of morbid obesity in Germany is associated with an increasing number of bariatric surgical interventions.Based on the effectiveness of bariatric surgery with regard to a significant reduction of body weight and comorbidity as well as improvement of the quality of life compared with conservative measures, its value and impact has been substantially increased. Long-term metabolic deficits such as nutrient deficiencies can be considered the main risks of various restrictive, combined and malabsorptive procedures of bariatric surgery...
September 2016: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/27275596/duodenum-inclusion-in-alimentary-transit-for-preventing-or-correcting-nutritional-deficiencies-resulting-from-roux-en-y-gastric-bypass-in-obesity-treatment
#15
Reginaldo Ceneviva
Nutritional and metabolic complications can develop after Roux-en-Y gastric bypass (RYGB) when there is an exaggerated response to the anatomical and functional changes or when there is inadequate nutritional supplementation. Severe malnutrition is rare, but deficiencies of vitamin B12, iron, calcium and thiamin, metabolic bone disease and gallstones are common after RYGB. Shortage of vitamin B12, iron, calcium and also cholelithiasis are caused at least partially by excluding the duodenum and proximal jejunum from food transit...
March 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/27188120/-progression-of-cryptogenic-iron-deficiency-anemia-and-efficacy-of-low-dose-prednisolone-in-a-rheumatic-case
#16
Satoshi Yamaguchi
Iron deficiency anemia (IDA) in rheumatic patients result from gastrointestinal bleeding owing usually tonon-steroidal anti-inflammatory agent. We experienced a rheumatic female patient in whom cryptogenic IDA deteriorated to 6.9 g x dl(-1) of hemoglobin (Hb) and 4 μg x dl(-1) of serum iron after surgery of femoral neck fracture. Considering the ascent of inflammatory reaction, we administered 5 mg per day of prednisolone(PSL) to her. In two month, IDA improved to 10.3 g x dl(-1)of Hb and 45 μg x dl(-1)of serum iron...
April 2016: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/27146660/investigating-nutritional-deficiencies-in-a-group-of-patients-3%C3%A2-years-post-laparoscopic-sleeve-gastrectomy
#17
Nazy Zarshenas, Maria Nacher, Ken W Loi, John O Jorgensen
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) as a single-stage procedure has shown to be effective in achieving significant weight loss and resolving obesity-related co-morbidities. However, its nutrition consequences have not been extensively explored. This study aims to investigate weight loss and evolution of nutritional deficiencies in a group of patients 3 years post LSG. METHODS: Retrospective data of a group of patients, 3 years following LSG as a stand-alone procedure was collected...
May 5, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27120933/-not-available
#18
REVIEW
A-C Magain, T Richard, B De Becker, S Rorive, A Benahmed, M Vanhaeverbeek
In Belgium and around the world, the weight-control surgery has grown significantly since the beginning of the 21st century. The principal argument in favour of this type of surgery is the expected reduction of the obesity-associated morbidities. However, the expectatif reduction of mortality associated with this kind of surgery is based on a low level of evidence. Besides the mechanical complications, there are a number of health-related problems associated with the post-operative metabolic changes. Authors of the present article have observed four cases presenting with serious affections consecutive to bariatric interventions and reviewed the literature...
January 2016: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/27068478/postoperative-intravenously-administered-iron-sucrose-versus-postoperative-orally-administered-iron-to-treat-post-bariatric-abdominoplasty-anaemia-isapa-the-study-protocol-for-a-randomised-controlled-trial
#19
Juan Carlos Montano-Pedroso, Elvio Bueno Garcia, Neil Ferreira Novo, Daniela Francescato Veiga, Lydia Masako Ferreira
BACKGROUND: Anaemia and iron deficiency are common complications following post-bariatric abdominoplasty. Given the low oral absorbability of iron resulting from bariatric surgery, it has been hypothesised that postoperative intravenously administered iron supplementation could be used to treat anaemia and to prevent the development of iron deficiency in these patients. METHODS/DESIGN: In this multicentre open-label randomised clinical trial, 56 adult women undergoing post-bariatric anchor-line abdominoplasty will be allocated at a ratio of 1:1 for postoperative supplementation with two intravenously administered applications of 200 mg of iron saccharate or postoperative supplementation with 100 mg of iron polymaltose complex administered orally, twice a day for 8 weeks...
April 12, 2016: Trials
https://www.readbyqxmd.com/read/27039102/iron-deficiency-anemia-after-laparoscopic-roux-en-y-gastric-bypass-in-chinese-obese-patients-with-type-2-diabetes-a-2-year-follow-up-study
#20
Haoyong Yu, Ronghui Du, Nina Zhang, Mingliang Zhang, Yinfang Tu, Lei Zhang, Yuqian Bao, Junfeng Han, Pin Zhang, Weiping Jia
BACKGROUND: This study was conducted to evaluate the prevalence of iron-deficiency anemia (IDA) after Roux-en-Y gastric bypass (RYGB) in Chinese obese patients with type 2 diabetes (T2DM). Furthermore, we evaluate potential predicting factors for onset of IDA after RYGB. METHODS: A total of 184 obese T2DM individuals who underwent RYGB were enrolled in the study. Patients were divided into three groups: male, premenopausal female, and postmenopausal female. Hematologic parameters were obtained prior to and after surgery on standardized time intervals up to 24 months postoperatively...
April 3, 2016: Obesity Surgery
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