Caroline J Bull, Emma Hazelwood, Danny N Legge, Laura J Corbin, Tom G Richardson, Matthew Lee, James Yarmolinsky, Karl Smith-Byrne, David A Hughes, Mattias Johansson, Ulrike Peters, Sonja I Berndt, Hermann Brenner, Andrea Burnett-Hartman, Iona Cheng, Sun-Seog Kweon, Loic Le Marchand, Li Li, Polly A Newcomb, Rachel Pearlman, Alex McConnachie, Paul Welsh, Roy Taylor, Mike E J Lean, Naveed Sattar, Neil Murphy, Marc J Gunter, Nicholas J Timpson, Emma E Vincent
BACKGROUND: Type 2 diabetes is associated with higher risk of several cancer types. However, the biological intermediates driving this relationship are not fully understood. As novel interventions for treating and managing type 2 diabetes become increasingly available, whether they also disrupt the pathways leading to increased cancer risk is currently unknown. We investigated the effect of a type 2 diabetes intervention, in the form of intentional weight loss, on circulating proteins associated with cancer risk to gain insight into potential mechanisms linking type 2 diabetes and adiposity with cancer development...
February 2024: EBioMedicine