keyword
https://read.qxmd.com/read/38416920/improving-time-to-diagnostic-resolution-in-the-breast-imaging-service-a-tertiary-center-s-experience-and-process-of-improvement
#21
JOURNAL ARTICLE
Nader A Fawzy, Noor F AlMuslem, Afaf Altayeb, Mohammad J Ghosheh, Nuha A Khoumais
OBJECTIVE: Breast imaging services often experience a significant degree of variability in patient flow, leading to delay in time to diagnostic resolution, commonly referred to as time to resolution (TTR). This study applies Lean Six Sigma Methodology (LSSM) to reduce TTR and enhance patient outcomes. METHODS: This study was IRB-approved. A baseline audit was done using cases of mammographic recalls (BI-RADS 0) to measure baseline TTR. Multidisciplinary meetings with all members of the breast imaging service, alongside a study of patient complaint data, were utilized to identify issues that were causing prolonged TTR...
September 22, 2023: Journal of breast imaging
https://read.qxmd.com/read/38407890/intermittent-fasting-regimens-for-metabolic-dysfunction-associated-steatotic-liver-disease-a-systematic-review-and-network-meta-analysis-of-randomized-controlled-trials
#22
JOURNAL ARTICLE
Mohamed T Abuelazm, Islam Mohamed, Ahmed Naeem, Yehya Khlidj, Mohammad Tanashat, Basant E Katamesh, Husam Abusuilik, Obieda Altobaishat, Mohamed Abdelnabi, Basel Abdelazeem
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent metabolic disorder characterized by excessive hepatic fat accumulation. Intermittent fasting (IF) has emerged as a potential therapeutic strategy with the ability to induce weight loss, improve insulin sensitivity and reduce hepatic steatosis. We aim to compare the efficacy of different IF regimens for MASLD management. A systematic review and network meta-analysis of randomized controlled trials investigating different IF regimens for MASLD...
April 1, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38404459/managing-resource-utilization-cost-of-laboratory-tests-for-patients-on-chemotherapy-in-johns-hopkins-aramco-healthcare
#23
JOURNAL ARTICLE
Huda Al-Sayed Ahmed, Nafeesa A Al-Faris, Joshua W Sharp, Issam O Abduljaber, Salam S Abou Ghaida
INTRODUCTION: Laboratory testing is a fundamental diagnostic and prognostic tool to ensure the quality of healthcare, treatment, and responses. This study aimed to evaluate the cost of laboratory tests performed for patients undergoing chemotherapy treatment in the oncology treatment center at Johns Hopkins Aramco Healthcare in Saudi Arabia. Additionally, we aimed to reduce the cost of unnecessary laboratory tests in a 1-year period. METHODS: This was a quality improvement study with a quasi-experimental design using DMAIC methodology...
November 2023: Glob J Qual Saf Healthc
https://read.qxmd.com/read/38393932/research-on-the-construction-of-information-based-nursing-quality-control-system-based-on-deep-learning-model-under-the-lean-perspective
#24
JOURNAL ARTICLE
Wan Pan, Yan Zhou, Yueping Ji, Lianfang Zhou, Li Wang
OBJECTIVE: In order to improve nursing quality management and protect patient medical safety, it is necessary to change the default mode and completely integrate information technology and nursing quality control utilising lean management. METHODS: A database was created, the nurse quality control scoring standard was entered into the computer and after the inspection, and various inspection reports were entered into the computer to precisely and promptly preserve data...
January 30, 2024: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://read.qxmd.com/read/38380190/revolutionising-quality-management-in-the-oral-pathology-laboratory-a-deep-dive-into-the-six-sigma-methodology
#25
REVIEW
Neha Kannan, Karthikeyan Ramalingam, Pratibha Ramani
Six Sigma Foundations is a statistical standard that indicates an exceptionally high level of quality, along with a customer satisfaction management approach that intends to lower error rates and boost process efficiency. The Define, Measure, Analyse, Improve, and Control (DMAIC) approach is a fundamental component of Six Sigma and provides an organised framework for process improvement. In contrast to conventional techniques that are more manual-based, Six Sigma emphasises and focuses on making decisions based on facts and evidence...
January 2024: Curēus
https://read.qxmd.com/read/38370796/intermittent-energy-restriction-inhibits-tumor-growth-and-enhances-paclitaxel-response-in-a-transgenic-mouse-model-of-endometrial-cancer
#26
Ziyi Zhao, Jiandong Wang, Weimin Kong, Ziwei Fang, Michael Coleman, Ginger Milne, Wesley C Burkett, Meredith A Newton, Douglas Lee, Beor Deng, Xiaochang Shen, Hongyan Suo, Wenchuan Sun, Stephen Hursting, Chunxiao Zhou, Victoria L Bae-Jump
OBJECTIVE: Overweight/obesity is the strongest risk factor for endometrial cancer (EC), and weight management can reduce that risk and improve survival. We aimed to establish the differential abilities of intermittent energy restriction (IER) and low-fat diet (LFD), alone and in combination with paclitaxel, to reverse the procancer effects of high-fat diet (HFD)-induced obesity in a mouse model of EC. METHODS: Lkb1 fl/fl p53 fl/fl mice were fed high-fat diet (HFD) or LFD to generate obese and lean phenotypes, respectively...
February 7, 2024: bioRxiv
https://read.qxmd.com/read/38370746/comparison-of-machine-leaning-models-for-prediction-of-acute-pain-severity-and-on-treatment-opioid-utilization-in-oral-cavity-and-oropharyngeal-cancer-patients-receiving-radiation-therapy-exploratory-analysis-from-a-large-scale-retrospective-cohort
#27
Vivian Salama, Laia Humbert-Vidan, Brandon Godinich, Kareem A Wahid, Dina M ElHabashy, Mohamed A Naser, Renjie He, Abdallah S R Mohamed, Ariana J Sahli, Katherine A Hutcheson, Gary Brandon Gunn, David I Rosenthal, Clifton D Fuller, Amy C Moreno
BACKGROUND: Acute pain is a common and debilitating symptom experienced by oral cavity and oropharyngeal cancer (OC/OPC) patients undergoing radiation therapy (RT). Uncontrolled pain can result in opioid overuse and increased risks of long-term opioid dependence. The specific aim of this exploratory analysis was the prediction of severe acute pain and opioid use in the acute on-treatment setting, to develop risk-stratification models for pragmatic clinical trials. MATERIALS AND METHODS: A retrospective study was conducted on 900 OC/OPC patients treated with RT during 2017 to 2023...
February 8, 2024: medRxiv
https://read.qxmd.com/read/38370191/analysis-of-processed-natural-gas-injection-on-hydrate-formation-in-high-pressure-refrigerated-condensate-lines
#28
JOURNAL ARTICLE
Iftikhar Ahmed, Shahbaz Abbas, Fahim Qaiser Jamal, Iftikhar Ahmad, Afshan Naseem, Abdul Malik Tahir
Natural gas and condensate are exposed to hydrates formation at high pressure and low temperature in the presence of traces of water. Hydrates formation results in blockage of pipelines and equipment leading to plant shutdown and production losses. This study intends to find a novel hydrate prevention process for high pressure refrigerated condensate (HPRC) lines. HPRC is utilised as lean oil for enhanced liquified petroleum gas recovery in absorption process. This research was conducted by performing fifteen tests in which various processed natural gas (PNG) samples were injected into different HPRC samples using Aspen HYSYS software...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38363252/sleep-bruxism-the-past-the-present-and-the-future-evolution-of-a-concept
#29
REVIEW
Davis C Thomas, Daniele Manfredini, Jaimin Patel, Aaron George, Bindu Chanamolu, Priyanka Kodaganallur Pitchumani, Linda Sangalli
BACKGROUND: The concept of sleep bruxism (SB) has evolved exponentially over the past several decades. Many theories and hypotheses have been proposed as to the definition, pathophysiology, and management of SB, from the early 1960s through the present. The role of peripheral factors, such as dental occlusion, in the pathogenesis of SB has been discarded. TYPES OF STUDIES REVIEWED: The authors searched several electronic databases (ie, PubMed, Google Scholar, Web of Science, Embase, and Ovid MEDLINE) for studies on bruxism...
February 16, 2024: Journal of the American Dental Association
https://read.qxmd.com/read/38361965/translation-of-a-diabetes-remission-service-into-australian-primary-care-findings-from-the-evaluation-of-direct-australia
#30
JOURNAL ARTICLE
Ritesh Chimoriya, Kimberly Mitlehner, Chee L Khoo, Uchechukwu Levi Osuagwu, Russell Thomson, Lei Si, Michael Lean, David Simmons, Milan K Piya
BACKGROUND: The Diabetes Remission Clinical Trial (DiRECT) study demonstrated that an intensive and structured weight management program in UK primary care resulted in high rates of diabetes remission in adults with recent onset type 2 diabetes mellitus (T2DM). This study was aimed at evaluating the translation of the DiRECT intervention into an Australian primary care setting. METHODS: All patients enrolled in the DiRECT-Australia Type 2 Diabetes Remission Service in a region of Sydney (Macarthur region, South Western Sydney, Australia) were included...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38359482/ecosystem-scale-insights-into-the-dynamics-of-dissolved-organic-matter-in-an-asia-s-largest-brackish-water-lagoon-sources-fluxes-and-biogeochemical-significance
#31
JOURNAL ARTICLE
Vishnu Vardhan Kanuri, Pradipta Ranjan Muduli, R S Robin, Charan Kumar Basuri, Lovaraju Avvari, Sivaji Patra, G V M Gupta, Nageswara Rao Gollapalli, B R Subramanian
A twenty-four month long observational study conducted in an Asia's largest brackish water ecosystem, Chilika Lagoon, India, aimed to unravel dissolved organic matter (DOM) dynamics in this tropical brackish water ecosystem. The study assessed the interplay between allochthonous and autochthonous DOM sources during lean and active flow periods based on regional rainfall. Dissolved organic carbon (DOC), nitrogen (DON), and phosphorus (DOP) fluxes were analyzed, considering catchment runoff, phytoplankton production, benthic-pelagic interactions, and sea-lagoon exchanges as contributors...
February 14, 2024: Marine Pollution Bulletin
https://read.qxmd.com/read/38343107/clinical-outcomes-and-adverse-events-of-bariatric-surgery-in-adults-with-severe-obesity-in-scotland-the-scots-observational-cohort-study
#32
JOURNAL ARTICLE
Ruth M Mackenzie, Abdulmajid Ali, Duff Bruce, Julie Bruce, Ian Ford, Nicola Greenlaw, Eleanor Grieve, Mike Lean, Robert S Lindsay, Joanne O'Donnell, Naveed Sattar, Sally Stewart, Jennifer Logue
BACKGROUND: Bariatric surgery is a common procedure worldwide for the treatment of severe obesity and associated comorbid conditions but there is a lack of evidence as to medium-term safety and effectiveness outcomes in a United Kingdom setting. OBJECTIVE: To establish the clinical outcomes and adverse events of different bariatric surgical procedures, their impact on quality of life and the effect on comorbidities. DESIGN: Prospective observational cohort study...
January 2024: Health Technology Assessment: HTA
https://read.qxmd.com/read/38341272/bringing-people-together-through-shared-purpose-and-identity-lessons-learnt-from-nhs-providers-ceo-sir-julian-hartley
#33
JOURNAL ARTICLE
Richard James, Julian Hartley, Laura Stroud
INTRODUCTION: The healthcare sector is facing increased demand with reduced resources, yet despite these challenges, leaders such as NHS Providers CEO Sir Julian Hartley have created cultures where the workforce can realise shared values, through a focus on staff engagement. This article describes Julian's journey, through the eyes of a doctor-in-training working in an organisation he has led, to understand what we can learn from his approach to leadership. NARRATIVE: As a manager, Julian saw how many different people it takes to make the NHS work, and decided the role of an NHS leader was to bring people together, through a strong sense of shared purpose and identity...
February 10, 2024: BMJ leader
https://read.qxmd.com/read/38338177/lean-six-sigma-approach-to-improve-the-management-of-patients-undergoing-laparoscopic-cholecystectomy
#34
JOURNAL ARTICLE
Arianna Scala, Giovanni Improta
Laparoscopic cholecystectomy (LC) is the gold standard technique for gallbladder diseases in both emergency and elective surgery. The incidence of the disease related to an increasingly elderly population coupled with the efficacy and safety of LC treatment resulted in an increase in the frequency of interventions without an increase in surgical mortality. For these reasons, managers implement strategies by which to standardize the process of patients undergoing LC. Specifically, the goal is to ensure, in accordance with the guidelines of the Italian Ministry of Health, a reduction in post-operative length of stay (LOS)...
January 23, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38323135/the-impact-of-dietary-fat-type-on-lipid-profiles-in-lean-mass-hyper-responder-phenotype
#35
Yuma Takemura, Tomoko Inoue, Keiji Matsunaga, Ryosuke Tani, Hai Ying Fu, Tetsuo Minamino
KEY CLINICAL MESSAGE: Although the lean mass hyper-responder (LMHR) phenotype is well known, its diagnosis is impeded by the influence of fat type and intake on the lipid profile. Accordingly, a detailed assessment is warranted if LMHR is suspected. ABSTRACT: A 47-year-old man with suspected familial hypercholesterolemia presented with elevated triglyceride and low-density lipoprotein cholesterol levels. He had adhered to a ketogenic diet and was suspected of a lean mass hyper-responder phenotype; however, his lipid profile did not meet the definition...
February 2024: Clinical Case Reports
https://read.qxmd.com/read/38313248/metabolic-puzzle-exploring-liver-fibrosis-differences-in-asian-metabolic-associated-fatty-liver-disease-subtypes
#36
JOURNAL ARTICLE
Sabhita Shabir Shaikh, Fakhar Ali Qazi-Arisar, Saba Nafay, Sidra Zaheer, Hafeezullah Shaikh, Zahid Azam
BACKGROUND: Metabolic-associated fatty liver disease (MAFLD) is a liver condition marked by excessive fat buildup in the absence of heavy alcohol use. It is primarily linked with metabolic issues like insulin resistance, obesity, and abnormal lipid levels, and is often observed with other conditions such as type 2 diabetes and cardiovascular disease. However, whether the subtypes of MAFLD based on the metabolic disorder differentially impact liver fibrosis is not well explicated, especially in the Asian population...
January 27, 2024: World Journal of Hepatology
https://read.qxmd.com/read/38292634/gut-targeted-therapies-for-type-2-diabetes-mellitus-a-review
#37
REVIEW
Tian-Cheng Xu, Yun Liu, Zhi Yu, Bin Xu
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance. The global prevalence of T2DM has reached epidemic proportions, affecting approximately 463 million adults worldwide in 2019. Current treatments for T2DM include lifestyle modifications, oral antidiabetic agents, and insulin therapy. However, these therapies may carry side effects and fail to achieve optimal glycemic control in some patients. Therefore, there is a growing interest in the role of gut microbiota and more gut-targeted therapies in the management of T2DM...
January 6, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38290287/impact-of-weight-loss-on-cancer-related-proteins-in-serum-results-from-a-cluster-randomised-controlled-trial-of-individuals-with-type-2-diabetes
#38
RANDOMIZED CONTROLLED TRIAL
Caroline J Bull, Emma Hazelwood, Danny N Legge, Laura J Corbin, Tom G Richardson, Matthew Lee, James Yarmolinsky, Karl Smith-Byrne, David A Hughes, Mattias Johansson, Ulrike Peters, Sonja I Berndt, Hermann Brenner, Andrea Burnett-Hartman, Iona Cheng, Sun-Seog Kweon, Loic Le Marchand, Li Li, Polly A Newcomb, Rachel Pearlman, Alex McConnachie, Paul Welsh, Roy Taylor, Mike E J Lean, Naveed Sattar, Neil Murphy, Marc J Gunter, Nicholas J Timpson, Emma E Vincent
BACKGROUND: Type 2 diabetes is associated with higher risk of several cancer types. However, the biological intermediates driving this relationship are not fully understood. As novel interventions for treating and managing type 2 diabetes become increasingly available, whether they also disrupt the pathways leading to increased cancer risk is currently unknown. We investigated the effect of a type 2 diabetes intervention, in the form of intentional weight loss, on circulating proteins associated with cancer risk to gain insight into potential mechanisms linking type 2 diabetes and adiposity with cancer development...
February 2024: EBioMedicine
https://read.qxmd.com/read/38276922/aga-clinical-practice-update-on-diet-and-nutritional-therapies-in-patients-with-inflammatory-bowel-disease-expert-review
#39
Jana G Hashash, Jaclyn Elkins, James D Lewis, David G Binion
DESCRIPTION: Diet plays a critical role in human health, but especially for patients with inflammatory bowel disease (IBD). Guidance about diet for patients with IBD are often controversial and a source of uncertainty for many physicians and patients. The role of diet has been investigated as a risk factor for IBD etiopathogenesis and as a therapy for active disease. Dietary restrictions, along with the clinical complications of IBD, can result in malnutrition, an underrecognized condition among this patient population...
January 23, 2024: Gastroenterology
https://read.qxmd.com/read/38276304/biomarkers-of-metabolic-adaptation-to-high-dietary-fats-in-a-mouse-model-of-obesity-resistance
#40
JOURNAL ARTICLE
Fadia Milhem, Leah M Hamilton, Emily Skates, Mickey Wilson, Suzanne D Johanningsmeier, Slavko Komarnytsky
Obesity-resistant (non-responder, NR) phenotypes that exhibit reduced susceptibility to developing obesity despite being exposed to high dietary fat are crucial in exploring the metabolic responses that protect against obesity. Although several efforts have been made to study them in mice and humans, the individual protective mechanisms are poorly understood. In this exploratory study, we used a polygenic C57BL/6J mouse model of diet-induced obesity to show that NR mice developed healthier fat/lean body mass ratios (0...
January 20, 2024: Metabolites
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