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Testosterone AND DHEA

Paul Toren, Azik Hoffman, Keyue Ding, France-Hélène Joncas, Veronique Turcotte, Patrick Caron, Frédéric Pouliot, Yves Fradet, Eric Levesque, Chantal Guillemette, Laurence H Klotz
PURPOSE: Phenotypic biomarkers are a high priority for patients receiving androgen deprivation therapy (ADT) for prostate cancer given the increasing number of treatment options. This study evaluates serum sex steroids as prognostic biomarkers in men receiving ADT for recurrent prostate cancer. EXPERIMENTAL DESIGN: Retrospective cohort study of Canadian patients in the PR.7 trial (accrual 1999-2005) who received continuous ADT for biochemical recurrence post-radiotherapy...
July 18, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
A Gunness, A Pazderska, M Ahmed, A McGowan, N Phelan, G Boran, A E Taylor, M W O'Reilly, W Arlt, K Moore, L A Behan, M Sherlock, J Gibney
STUDY QUESTION: What information does androgen profiling using liquid chromatography tandem mass spectrometry (LC-MS/MS) provide in reproductive-age women with Type 1 diabetes (T1D)? SUMMARY ANSWER: In T1D women, androstenedione proved most useful of the measured androgens in differentiating subgroups based on clinical phenotypes of hyperandrogenism (HA) and polycystic ovary syndrome (PCOS). WHAT IS KNOWN ALREADY: The prevalence of HA and PCOS are increased in women with T1D...
July 18, 2018: Human Reproduction
Claudia Lozano C, Marcela Molina P
INTRODUCTION: Among the causes of peripheral precocious puberty in men are the beta-human cho rionic gonadotropin (Β-HCG)-secreting tumors, such as hepatoblastomas, dysgerminomas, chorio carcinomas, and immature teratomas. In pediatrics, the mediastinal teratomas are rare, representing the 7-10% of extragonadal teratomas. OBJECTIVE: To describe the case of a patient with peripheral precocious puberty due to a Β-HCG -secreting thymic teratoma. CLINICAL CASE: A seven-years-old schoolboy presents a three-months history of voice changes, gynecomastia, pubic hair appearance, and increased genital volume...
June 2018: Revista Chilena de Pediatría
S Hoppler, A Walther, P La Marca-Ghaemmaghami, U Ehlert
In males, age-related decline in free testosterone (T) and dehydroepiandrosterone (DHEA) by 2-3% per year has been reported. Estradiol (E2) and progesterone (P) seem to decrease as well, but to a lesser extent. Lower sex steroid levels in men have been related to physical and mental symptoms. Low birthweight and left-/mixed-handedness (L/MH) are indicators of an adverse fetal environment during pregnancy, and both have been linked to morbidity in later life. The aim of this study is to examine the relationship between lower birthweight as well as L/MH and age-related sex steroid decline...
July 11, 2018: Andrology
Selenay Furat Rencber, Sema Kurnaz Ozbek, Ceyla Eraldemır, Zehra Sezer, Tugba Kum, Sureyya Ceylan, Elif Guzel
BACKGROUND: PCOS is a reproductive hormonal abnormality and a metabolic disorder. It is frequently associated with insulin resistance, hyperandrogenism, chronic inflammation, and oxidative stress. We aim to investigate the potential therapeutic effects of combined therapy of resveratrol and metformin on polycystic ovaries via SIRT1 and AMPK activation. METHODS: Wistar albino rats were divided into control and experimental (PCOS) groups. DHEA-induced PCOS rats were given resveratrol (20 mg/kg/day), metformin (300 mg/kg/day) and combined therapy...
June 29, 2018: Journal of Ovarian Research
Ana Savic-Radojevic, Ilijana Mazibrada, Tatjana Djukic, Zoran B Stankovic, Marija Pljesa-Ercegovac, Katarina Sedlecky, Jelica Bjekic-Macut, Tatjana Simic, George Mastorakos, Djuro Macut
INTRODUCTION: It has been supposed that endocrine disturbances might be responsible for PCOS-associated oxidative stress, with special emphasis on hyperandrogenism.Considering potential relationship between hyperandrogenism and increased free radicals production, parameters of oxidative stress were determined in non-obese normoinsulinemic adolescent girls newly diagnosed with polycystic ovary syndrome (PCOS). MATERIAL AND METHODS: Nitrotyrosine, thiol groups' concentrations, glutathione peroxidase and superoxide dismutase activities were determined under fasting conditions and during oral glucose tolerance test (OGTT) in 35 PCOS patients and 17 controls...
June 28, 2018: Endokrynologia Polska
Yifat Gadot, John-Olof Thörngren, Emma Eklund, Lena Ekström, Anders Rane
Objective: To investigate the excretion and conjugation profile of testosterone (T), Epitestosterone (EpiT), and other androgen metabolites in different phases of pregnancy and postpregnancy as a reflection of the "androgenic exposure." Design: Consecutive recruitment of pregnant women. Setting: Maternity outpatient low-risk pregnancy clinic. Patients: Seventy-seven pregnant women. Interventions: Collection of urine for analyses of sulfate (S) and glucuronide (G) conjugates and metabolic ratios of androgens and androgen metabolites using liquid chromatography-tandem mass spectrometry...
July 1, 2018: Journal of the Endocrine Society
Gholamali Jelodar, Sajjad Masoomi, Farhad Rahmanifar
Objectives: Herbal medicines are an alternative choice for treatment or controlling of polycystic ovary syndrome (PCOS). Effect of hydroalcoholic extract of flaxseed was evaluated on ovarian hormones and histological changes of uterus and ovary in a PCOS-induced rat model. Materials and Methods: Twenty four rats divided into four groups including negative control, positive control, PCOS and treatment groups. Positive control group received hydroalcoholic extract of flaxseed for 30 days...
June 2018: Iranian Journal of Basic Medical Sciences
Nicolas Gravisse, Nancy Vibarel-Rebot, Zakaria Labsy, Manh-Cuong Do, Olivier Gagey, Céline Dubourg, Michel Audran, Katia Collomp
WADA has banned dehydroepiandrosterone (DHEA) but its ergogenic effect in female athletes has never been investigated. The aim of this study was to determine whether short-term DHEA intake would improve performance during a supramaximal field exercise in healthy young recreationally trained women. Its impact on body composition, metabolic responses was also measured. Eleven young female volunteers completed four running-based anaerobic sprint tests: just before and after treatment with either oral placebo or DHEA (100 mg/day/28days), following a double-blind and randomized protocol...
June 25, 2018: International Journal of Sports Medicine
Shanshan Zhao, Xiaoyin Wang, Yu Wang, Junjie Xu, Gang Zhu, Chuansheng Zhao, Weiyu Teng
BACKGROUND: Valproate (VPA) is a broad spectrum antiepileptic drug (AED) that is generally used as a first line agent for most idiopathic and symptomatic generalized epilepsies. Many studies have indicated that AEDs cause reproductive endocrine disorders in males, but the exact etiology underpinning these dysfunctions is not clear. This meta-analysis and systematic review was intended to evaluate the effect of VPA on reproductive endocrine function in male patients with epilepsy. METHODS: A literature search was performed using electronic databases up to December 2017 for eligible studies...
June 22, 2018: Epilepsy & Behavior: E&B
Fatma Ela Keskin, Hande Mefkure Özkaya, Mazhar Ortaç, Emre Salabaş, Ateş Kadıoğlu, Pınar Kadıoğlu
OBJECTIVE: The aim of this study is to determine the severity of female sexual dysfunction (FSD), quality of life, and depression status in female patients with Cushing's syndrome (CS). MATERIAL AND METHODS: This study included 29 sexually active women with CS and 30 healthy age and body mass index matched women. The Female Sexual Function Index (FSFI) questionnaire, Beck Depression Inventory (BDI) and Short Form Health Survey (SF-36) were filled by each participant...
July 2018: Turkish Journal of Urology
Gisela Soledad Bracho, Gabriela Anahí Altamirano, Laura Kass, Enrique Hugo Luque, Verónica Lis Bosquiazzo
The effects of androgens on the uterus have been poorly studied and they need to be clarified to understand why androgen excess, such as observed in women with polycystic ovary syndrome (PCOS), is a risk factor for the development of endometrial hyperplasia, cancer, and infertility. Thus, uterine histomorphology in a PCOS experimental model was evaluated. Beginning at weaning, female rats were injected daily with dehydroepiandrosterone (DHEA, 6 mg/100 g body weight) or vehicle (sesame oil) for 20 consecutive days...
January 1, 2018: Reproductive Sciences
Monik C Jiménez, Lu Wang, Julie E Burnig, JoAnn E Manson, John P Forman, Howard D Sesso
INTRODUCTION: Higher levels of total testosterone and lower levels of sex hormone-binding globulin (SHBG) have been associated with increased blood pressure (BP) in women with an inverse association between total testosterone and BP among men. Fewer studies have examined associations with 24-h ambulatory blood pressure (ABP), blunted nocturnal BP decline or the role of dehydroepiandrosterone sulfate (DHEAS), a precursor to androgens. METHODS: Baseline blood samples were assayed for 229 normotensive men (≥50 years) and women (≥55 years) participating in the VITamin D and OmegA-3 TriaL...
June 20, 2018: Journal of Hypertension
T H Johannsen, K M Main, M L Ljubicic, T K Jensen, H R Andersen, M S Andersen, J H Petersen, A-M Andersson, A Juul
CONTEXT: The early activation of the hypothalamic-pituitary-gonadal axis during infancy can be used in the evaluation of infants suspected of disorders of sex development (DSD). However, few data exists on sex-specific reference ranges for these hormones during early life. OBJECTIVE: To evaluate sex-differences in reproductive hormone concentrations in serum from healthy infants in order to define sex-specific cut-off values and to apply these in infants with DSD...
June 15, 2018: Journal of Clinical Endocrinology and Metabolism
Timothy S McHale, Wai-Chi Chee, Ka-Chun Chan, David T Zava, Peter B Gray
A large body of research links testosterone and cortisol to male-male competition. Yet, little work has explored acute steroid hormone responses to coalitional, physical competition during middle childhood. Here, we investigate testosterone, dehydroepiandrosterone (DHEA), androstenedione, and cortisol release among ethnically Chinese boys in Hong Kong (N = 102), aged 8-11 years, during a soccer match (n = 84) and an intrasquad soccer scrimmage (n = 81), with 63 participants competing in both treatments. The soccer match and intrasquad soccer scrimmage represented out-group and in-group treatments, respectively...
June 16, 2018: Human Nature: An Interdisciplinary Biosocial Perspective
Yu V Ukraintseva, K M Liaukovich, А A Polishchuk, О V Martynova, D A Belov, E S Simenel, М Meira E Cruz, А N Nizhnik
OBJECTIVES: Levels of steroid hormones such as androgens and cortisol exhibit circadian variation, and their fluctuations are related to the sleep-wake cycle. Currently, the functional role of different stages of sleep in steroid hormone secretion remains unclear. The present study aims to explore the effect of slow-wave sleep (SWS) suppression on morning levels of cortisol and androgens. METHODS: Twelve healthy male volunteers participated in two experimental sessions: a session with selective SWS suppression during night sleep and a session with regular night sleep (control)...
August 2018: Sleep Medicine
Iwona Rotter, Aleksandra Rył, Katarzyna Grzesiak, Aleksandra Szylińska, Wioletta Pawlukowska, Anna Lubkowska, Olimpia Sipak-Szmigiel, Krzysztof Pabisiak, Maria Laszczyńska
Introduction/Objective : The aim of the study was to show which of the adipose tissue accumulation indicators correlate with testosterone disorders in non-diabetic aging men. Material and methods : 455 non diabetic men, recruited at primary care facilities, aged 50⁻75 participated in the study. The participants underwent anthropometric measurement and ELISA determination of total testosterone (TT), estradiol (E₂), dehydroepiandrosterone sulphate (DHEA-S), sex hormone binding protein (SHBG), and the determination of fasting glucose (FPG), high-density lipids cholesterol (HDL-Ch), and triacylglycerols (TAG) in serum...
June 8, 2018: International Journal of Environmental Research and Public Health
Michał Rabijewski, Lucyna Papierska, Radosław Maksym, Ryszard Tomasiuk, Anna Kajdy, Bogusław Paweł Siekierski
The aim of this study was to compare health-related quality of life (HRQoL) between men with prediabetes (PD) and a control group as well as to investigate the relationship between HRQoL and anabolic hormones. The analysis was carried out in 176 middle-aged (40-59 years) and elderly (60 80 years) men with PD, and 184 control peers. PD was defined according the American Diabetes Association and HRQoL was assessed by the SF-36 questionnaire. Total testosterone (TT), calculated free testosterone, dehydroepiandrosterone sulfate (DHEAS), and insulin-like growth factor 1 (IGF-1) were measured...
June 1, 2018: American Journal of Men's Health
Nguyen Thi Phuong Oanh, Teruhiko Kido, Seijiro Honma, Yuko Oyama, Le Thai Anh, Hoang Duc Phuc, Nguyen Hoang Viet, Ho Dung Manh, Rie Okamoto, Hideaki Nakagawa, Shoji F Nakayama, Dang Duc Nhu, Dao Van Tung, Vo Van Chi, Nguyen Hung Minh, Ngo Van Toan
Dioxins have been suspected to be potential substances causing endocrine disruptions in humans. We are conducting the research in one of three dioxin exposure areas (hotspots) in Vietnam. We previously reported that the salivary dehydroepiandrosterone (DHEA) level decreased in 3-year-old Vietnamese children and that it was significantly inversely correlated with polychlorinated dibenzodioxin/dibenzofuran levels in their mother's breast milk. In this study, we investigated the influence of exposure to dioxin on steroid hormone biosynthesis in the same children when they reached 5 years of age, focusing on androgens...
June 1, 2018: Science of the Total Environment
Marjaana Viljanto, Pamela Hincks, Lynn Hillyer, Adam Cawley, Craig Suann, Glenys Noble, Christopher J Walker, Mark C Parkin, Andrew T Kicman, James Scarth
The use of testosterone and its pro-drugs, such as dehydroepiandrosterone (DHEA), is currently regulated in horseracing by the application of international testosterone thresholds. However, additional steroidomic approaches, such as steroid ratios, to distinguish overall adrenal stimulation from drug administrations and an equine biological passport for longitudinal steroid profiling of individual animals could be advantageous in equine doping testing. Thus, DHEA concentrations and related ratios (testosterone [T] to DHEA and DHEA to epitestosterone [E]) were assessed in the reference population by quantitative analysis of 200 post-race gelding urine samples using liquid chromatography-tandem mass spectrometry...
May 24, 2018: Drug Testing and Analysis
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