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Testosterone AND DHEA

Teng-Fei Yuan, Juan Le, Yan Cui, Rui Peng, Shao-Ting Wang, Yan Li
BACKGROUND: Comprehensive serum sex hormone profiling is essential for monitoring the occurrence and development of many related diseases. However, the current methods for multi-class sex hormone detection were always lack of Standard Reference Material (SRM) certification and suffered from large sample consumption. For improvement, we developed a new liquid chromatography-tandem mass spectrometry (LC-MS/MS) method focused on SRM certification and minimization of serum consumption for simultaneous quantification of seven mainstream serum sex hormones including estrogens (estrone E1, estradiol E2 and estriol E3), androgens (testosterone T, androstenedione AD, dehydroepiandrosterone DHEA) and progestogens (progesterone P)...
September 6, 2018: Journal of Pharmaceutical and Biomedical Analysis
Sabine Naessén, Gunnar Söderqvist, Kjell Carlström
Hyper androgen state frequently can be diagnosed in bulimic women. Eating disorder not otherwise specified (EDNOS) recognized as a less severe form of bulimia nervosa (BN). The objective of the study was to determine whether androgen levels and androgen origin differs in bulimic women compared to control subjects. Forty-six women with bulimia nervosa (BN), 31 with eating disorder not otherwise specified, purging type (EDNOS P) and 56 matched healthy controls were studied with respect to serum testosterone (T), 5alpha-dihydrotestosterone (DHT), sex hormone-binding globulin (SHBG), deyhydroepiahndrosterone sulfate (DHEAS) and luteinizing hormone (LH) and to ovarian morphology...
August 30, 2018: Journal of Steroid Biochemistry and Molecular Biology
Chao-Yan Yue, Lou-Kai-Yi Lu, Meng Li, Qian-Lan Zhang, Chun-Mei Ying
OBJECTIVE: We intended to establish the threshold for anti-Mullerian hormone (AMH) in the diagnosis of polycystic ovary syndrome (PCOS) in China. METHODS: A total of 771 women (653 with PCOS and 118 healthy controls) were enrolled. The serum AMH, follicle-stimulating hormone (FSH), luteinizing hormone (LH), FSH/LH, prolactin, estradiol, testosterone (T), dehydroepiandrosterone sulfate (DHEA-S), sex hormone-binding globulin (SHBG), 17α-OH progesterone (17α-OHP), fasting insulin (INS), fasting glucose, free androgen index (FAI%) and homeostasis model assessment for insulin resistance (HOMA-IR) index were analyzed, and the diagnostic utility of AMH, LH/FSH, T and INS was established using receiver operator characteristic (ROC) curves...
2018: PloS One
Veera Vihma, Sini Heinonen, Jussi Naukkarinen, Jaakko Kaprio, Aila Rissanen, Ursula Turpeinen, Esa Hämäläinen, Antti Hakkarainen, Jesper Lundbom, Nina Lundbom, Tomi S Mikkola, Matti J Tikkanen, Kirsi H Pietiläinen
OBJECTIVE: Obesity may alter serum steroid concentrations and metabolism. We investigated this in healthy young women with increased body fat and their leaner co-twin sisters. DESIGN: Age and genetic background both strongly influence serum steroid levels and body composition. This is a cross-sectional study of 13 female monozygotic twin pairs (age, 23-36 years), ten of which were discordant for body mass index (median difference in body weight between the co-twins, 19 kg)...
August 25, 2018: Steroids
Jodi A Quas, Amy Castro, Crystal I Bryce, Douglas A Granger
In contrast to a large body of work concerning the effects of physiological stress reactivity on children's socioemotional functioning, far less attention has been devoted to understanding the effects of such reactivity on cognitive, including mnemonic, functioning. How well children learn and remember information under stress has implications for a range of educational, clinical, and legal outcomes. We evaluated 8-14 year olds' (N = 94, 50 female) memory for negative, neutral, and positive images. Youth had seen the images a week previously as a part of a laboratory stress task...
September 2018: Developmental Psychology
Juilee Rege, Adina Turcu, Josephine Z Kasa-Vubu, Antonio M Lerario, Gabriela C Auchus, Richard J Auchus, Joshua M Smith, Perrin C White, William E Rainey
Context: Adrenarche refers to the rise of dehydroepiandrosterone sulfate (DHEA-S) associated with the development of a functional adrenal zona reticularis. Clinical features of adrenarche include onset of body odor, axillary and pubic hair, which reflect increased androgen action. An early rise in adrenal androgens or premature adrenarche (PremA) is a risk factor for adverse metabolic profiles in adolescence and adulthood. The bioactive androgens associated with adrenarche and PremA remain poorly understood...
August 17, 2018: Journal of Clinical Endocrinology and Metabolism
Wendy Ying, Di Zhao, Pamela Ouyang, Vinita Subramanya, Dhananjay Vaidya, Chiadi E Ndumele, Kavita Sharma, Sanjiv J Shah, Susan R Heckbert, Joao A Lima, Christopher R deFilippi, Matthew J Budoff, Wendy S Post, Erin D Michos
Context: Sex hormones (SH) are thought to influence sex differences in cardiovascular disease (CVD). N-Terminal pro-B-type Natriuretic Peptide (NT-proBNP), a predictor of CVD, is higher in women than men, which may relate to SH. Objective: To evaluate whether SH [Total testosterone (T), bioavailable T, free T, estradiol, dehydroepiandrosterone (DHEA), SH binding globulin (SHBG)] are associated with cross-sectional and longitudinal NT-proBNP levels. Design: Cohort study (MESA)...
August 20, 2018: Journal of Clinical Endocrinology and Metabolism
Naeimeh Tayebi, Zahra Yazdanpanahi, Shahrzad Yektatalab, Saeedeh Pourahmad, Marzieh Akbarzadeh
OBJECTIVE: The present research aimed to study the relationship between body mass index and menstrual disorders at different ages of menarche and sex hormones. METHODS: In this cross-sectional study, 2000 girls aged between 9 and 18 in all levels were selected through cluster sampling in Shiraz. Data were collected using demographic characteristics, menstrual disorders, body mass index and hormones' measure questionnaires. To analyze the data, we used SPSS 16 and Chi-square test...
November 23, 2017: Journal of the National Medical Association
Eleni Pitsouni, Themos Grigoriadis, Athanasios Douskos, Margarita Kyriakidou, Matthew E Falagas, Stavros Athanasiou
Genitourinary syndrome of menopause (GSM) increases the probability of female sexual dysfunction (FSD). The aim of the current study is to systematically assess data regarding sexual function and use of vaginal therapies, alternative to vaginal estrogens (VE), in menopausal women with GSM. PubMed, Scopus and Cochrane Library were searched (May-September 2017) using combination keywords: "dyspareunia and vaginal therapy", "sexual function and vaginal therapy", "orgasm and vaginal therapy", "vaginal atrophy" and "genitourinary syndrome of menopause"...
August 6, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Jyoti Aggarwal, Rajesh Satyapal Taneja, Pulin Kumar Gupta, Mohsin Wali, Anubhuti Chitkara, Afroz Jamal
Background: In human immunodeficiency virus (HIV)-infected men, hypogonadism is the most common endocrinological disorder, and most cases of hypogonadism are secondary. The aim of this study was to find out the hormonal abnormalities in HIV-infected males and it's correlation with CD4 cell counts. Materials and Methods: One hundred HIV-infected male patients were evaluated in the Department of Medicine, Postgraduate Institute of Medical Education and Research and Dr...
May 2018: Indian Journal of Endocrinology and Metabolism
T N Enina, V A Kuznetsov, A M Soldatova, T I Petelina, D V Krinochkin, S M Dyachkov, A Y Rychkov, T Y Gorbunova
AIM: To study the relationship between levels of sex hormones and effectiveness of cardiac resynchronisation therapy (CRT) in men with chronic heart failure (CHF). MATERIALS AND METHODS: The best response to CRT (mean time, 38 [19,0;53,7] months) was identifed by a maximum decrease in left ventricular end-systolic volume (LVESV) in 58 men (mean age, 54.8±9.6) with CHF (61% IHD). Based on testosterone (TES) level, patients were divided into group 1 (n=28; 48%) - TES < median value (13...
2018: Kardiologiia
Melanie LaVoie, Vasilis Constantinides, Noel Robin, Angelos Kyriacou
A 26-year-old woman with a history of polycystic ovarian syndrome presented with secondary amenorrhea, worsening hirsutism, acne, deepening of voice and unexplained 10-20 kg weight gain. Her Ferriman-Gallway hirsutism score was 12 with cystic facial acne and increased masculine phenotype. Urine Beta-Human Chorionic Gonadotropins (bHCG) was negative. She had elevated serum testosterone of 551 ng/dL, androstenedione at 7.46 ng/mL and dehydroepiandrosterone sulfate (DHEAS) at 4243 µg/L. Overnight dexamethasone suppression test showed mildly unsuppressed cortisol (2...
July 30, 2018: BMJ Case Reports
Mehri Javid, Bahman Nickavar, Hossein Vahidi, Mohammad Ali Faramarzi
Microbial transformations are capable of producing steroid substances difficult to synthesize by chemical methods. Strains belonging to the genus Aspergillus are effective facilitators of microbial biotransformations due to their enzymatic diversity. In this study, the biotransformation of progesterone by the fungus Aspergillus sojae (A. sojae) PTCC 5196 was examined. Analysis of the bioconversion process revealed that progesterone was converted to testololactone through a three-step pathway (17β-acetyl side chain cleavage, 17β-hydroxyl oxidation, and oxygenative lactonization of 17-ketone), indicating the presence of Baeyer-Villiger monooxygenase (BVMO) activity in the fungal strain...
July 25, 2018: Steroids
Emaduldin Seyam, Enas Hefzy
The aim of the current work was to investigate the value of the long term effects of combined use of simvastatin and metformin treatment for a year versus the effects of their individual treatment on the clinical, biochemical abnormalities, and ovulation dysfunction in young single women with polycystic ovary syndrome (PCOS). It was a randomized, double-blind controlled study. Where two hundreds (n = 200) single young women with PCOS were randomized into seventy (n = 70) women using simvastatin 20 mg daily combined with metformin 500 mg three times daily considered as group A (study group), and another 2 sixty five (n = 65) women groups using simvastatin and metformin individually as a single treatment use, and considered as groups (B & C), respectively...
July 25, 2018: Gynecological Endocrinology
Stefan Poschner, Alexandra Maier-Salamon, Martin Zehl, Judith Wackerlig, Daniel Dobusch, Anastasia Meshcheryakova, Diana Mechtcheriakova, Theresia Thalhammer, Bettina Pachmann, Walter Jäger
The role of resveratrol (RES) in preventing breast cancer is controversial, as low concentrations may stimulate the proliferation of estrogen-receptor alpha positive (ERα+) breast cancer cells. As metabolism is the key factor in altering cellular estrogens, thereby influencing breast tumor growth, we investigated the effects of RES on the formation of estrogen metabolites, namely 4-androstene-3,17-dione (AD), dehydroepiandrosterone (DHEA), dehydroepiandrosterone-3- O -sulfate (DHEA-S), estrone (E1), estrone-3-sulfate (E1-S), 17β-estradiol (E2), 17β-estradiol-3- O -(β-D-glucuronide) (E2-G), 17β-estradiol-3- O -sulfate (E2-S), 16α-hydroxy-17β-estradiol (estriol, E3), and testosterone (T) in ERα- MDA-MB-231 and ERα+ MCF-7 cells...
2018: Frontiers in Pharmacology
Marjolein E A Barendse, Julian G Simmons, Michelle L Byrne, George Patton, Lisa Mundy, Craig A Olsson, Marc L Seal, Nicholas B Allen, Sarah Whittle
OBJECTIVE: The transition from childhood to adolescence is a vulnerable period for the development of anxiety symptoms. There is some evidence that hormonal changes occurring during adrenarche, an early pubertal phase, might play a role in this increased vulnerability. Little is known about underlying brain mechanisms. Given the role of the amygdala-based fear circuit in anxiety, the current study aimed to investigate whether children's adrenarcheal hormone levels were associated with functional connectivity of the amygdala while processing fearful facial expressions, and how this in turn related to anxiety symptoms...
November 2018: Psychoneuroendocrinology
R Wang, D Tiosano, A Sánchez-Guijo, M F Hartmann, S A Wudy
Growth and development of an embryo or fetus during human pregnancy mainly depend on intact hormone biosynthesis and metabolism in maternal amniotic fluid (AF). We investigated the hormonal milieu in AF and developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of 14 sulfated and 6 unconjugated steroids in AF. 65 A F samples (male: female = 35: 30) of mid-gestation ranging from 16th week of gestation to 25th week of gestation were analyzed. Reference data of 20 steroid levels in AF of healthy women were provided...
July 18, 2018: Journal of Steroid Biochemistry and Molecular Biology
Trevor M Penning
Dehydroepiandrosterone (DHEA)-SO4 of adrenal origin is the major C19 steroid in the serum. It is a precursor of intratumoral androgen biosynthesis in patients with advanced prostate cancer following chemical or surgical castration. DHEA is a product of the P450c17 (17α-hydroxylase-17,20-lyase) enzyme. Despite inhibition of P450c17 with new agents, e.g., Abiraterone acetate, Orterenol, and Galeterone, the level of enzyme inhibition rarely exceeds 90% leaving behind a significant depot for androgen biosynthesis within the tumor...
2018: Vitamins and Hormones
Barbara J Clark, Russell A Prough, Carolyn M Klinge
Dehydroepiandrosterone (3β-hydroxy-5-androsten-17-one, DHEA) and its sulfated metabolite DHEA-S are the most abundant steroids in circulation and decline with age. Rodent studies have shown that DHEA has a wide variety of effects on liver, kidney, adipose, reproductive tissues, and central nervous system/neuronal function. The mechanisms by which DHEA and DHEA-S impart their physiological effects may be direct actions on plasma membrane receptors, including a DHEA-specific, G-protein-coupled receptor in endothelial cells; various neuroreceptors, e...
2018: Vitamins and Hormones
Bindu N Chimote, Natchandra M Chimote
Steroid hormones form an integral part of normal development in mammalian organisms. Cholesterol is the parent compound from which all steroid hormones are synthesized. The product pregnenolone formed from cholesterol serves as precursor for mineralocorticoids, glucocorticoids, as well as dehydroepiandrosterone (DHEA) and its derived sexual hormones. DHEA assumes the prohormone status of a predominant endogenous precursor and a metabolic intermediate in ovarian follicular steroidogenesis. DHEA supplementation has been used to enhance ovarian reserve...
2018: Vitamins and Hormones
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