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Testosterone AND DHEA

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https://www.readbyqxmd.com/read/29342266/causes-patterns-and-severity-of-androgen-excess-in-1205-consecutively-recruited-women
#1
Yasir S Elhassan, Jan Idkowiak, Karen Smith, Miriam Asia, Helena Gleeson, Rachel Webster, Wiebke Arlt, Michael W O'Reilly
Context: Androgen excess in women is predominantly due to underlying polycystic ovary syndrome (PCOS). However there is a lack of clarity regarding patterns and severity of androgen excess that should be considered predictive of non-PCOS pathology. Objective: We examined the diagnostic utility of simultaneous measurement of serum dehydroepiandrosterone sulfate (DHEAS), androstenedione (A4) and testosterone (T) to delineate biochemical signatures and cut-offs predictive of non-PCOS disorders in women with androgen excess...
January 12, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29335782/association-of-endogenous-circulating-sex-steroids-and-condition-specific-quality-of-life-domains-in-postmenopausal-women-with-pelvic-floor-disorders
#2
Barbara Bodner-Adler, Klaus Bodner, Oliver Kimberger, Ksenia Halpern, Heinz Koelbl, Wolfgang Umek
OBJECTIVE: To examine the relationship between endogenous sex steroids and various condition-specific quality of life domains in postmenopausal women with pelvic floor disorders. We hypothesized that woman with lowest androgen and estradiol concentrations would report worse scores of quality of life domains. METHODS: Forty-six women with pelvic organ prolapse (POP) and 47 cases with stress urinary incontinence (SUI) answered the validated pelvic floor questionnaire and underwent serum sex steroid measurement...
January 15, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29334627/testosterone-dhea-and-dhea-s-in-patients-with-schizophrenia-a-systematic-review-and-meta-analysis
#3
REVIEW
Błażej Misiak, Dorota Frydecka, Olga Loska, Ahmed A Moustafa, Jerzy Samochowiec, Justyna Kasznia, Bartłomiej Stańczykiewicz
Neuroactive steroids, including testosterone, dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) might play an important role in the pathophysiology of schizophrenia. Therefore, we performed a systematic review and meta-analysis of studies comparing the levels of testosterone, DHEA and DHEA-S in patients with schizophrenia and healthy controls. We searched electronic databases from their inception until Oct 29, 2017. Effect size (ES) estimates were calculated as Hedges' g. Data analysis was performed using random-effects models...
January 9, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29330698/circulating-hormones-and-mammographic-density-in-premenopausal-women
#4
Kimberly A Bertrand, A Heather Eliassen, Susan E Hankinson, Bernard A Rosner, Rulla M Tamimi
Prior research suggests that several endogenous hormones in premenopausal women are associated with breast cancer risk; however, few studies have evaluated associations of endogenous hormones with mammographic density (MD) in premenopausal women. We conducted a cross-sectional study of plasma hormone levels in relation to MD among 634 cancer-free premenopausal women in the Nurses' Health Study II. We measured percent MD from screening mammograms using a computer-assisted method. We assayed estradiol, estrone, and estrone sulfate in blood samples timed in early follicular and mid-luteal phases of the menstrual cycle as well as testosterone, androstenedione, progesterone, dehydroepiandrosterone (DHEA), DHEA sulfate, sex hormone-binding globulin (SHBG), and anti-Müllerian hormone in luteal or untimed samples...
January 12, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29324787/association-of-sex-hormones-with-physical-laboratory-and-imaging-markers-of-anthropometry-in-men-and-women-from-the-general-population
#5
Tom Seyfart, Nele Friedrich, Hanna Kische, Robin Bülow, Henri Wallaschofski, Henry Völzke, Matthias Nauck, Brian G Keevil, Robin Haring
OBJECTIVES: The aim of this study was to evaluate the association of sex hormones with anthropometry in a large population-based cohort, with liquid chromatography-mass spectrometry (LCMS)-based sex hormone measurements and imaging markers. STUDY DESIGN/MAIN OUTCOME MEASURES: Cross-sectional data from 957 men and women from the population-based Study of Health in Pomerania (SHIP) were used. Associations of a comprehensive panel of LCMS-measured sex hormones with anthropometric parameters, laboratory, and imaging markers were analyzed in multivariable regression models for the full sample and stratified by sex...
2018: PloS One
https://www.readbyqxmd.com/read/29323690/premature-adrenarche
#6
Laura Novello, Phyllis W Speiser
Adrenarche is when a child's adrenal cortex starts to secrete adrenal androgen precursors. Dehydroepiandrosterone (DHEA) is the most abundant product of the adrenal cortex, and is a weak androgen agonist thought to be responsible for the clinical signs of pubarche by conversion to more potent androgens, testosterone, and dihydrotestosterone. DHEA's extra-adrenal sulfation product, dehydroepiandrosterone sulfate, is a stable marker for adrenal androgenic activity. Pubarche is the physical manifestation of androgenic hormone production, and includes the development of pubic and axillary hair, adult body odor, and acne...
January 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29322301/effects-of-short-term-dhea-intake-on-hormonal-responses-in-young-recreationally-trained-athletes-modulation-by-gender
#7
Katia Collomp, Corinne Buisson, Nicolas Gravisse, Soraya Belgherbi, Zakaria Labsy, Manh-Cuong Do, Olivier Gagey, Sophie Dufay, Nancy Vibarel-Rebot, Michel Audran
BACKGROUND: Dehydroepiandrosterone (DHEA) figures on the World Anti-Doping Agency list of prohibited substances in sport because it is assumed that athletes expect a significant increase in testosterone through DHEA administration. The literature on the hormonal effects of DHEA intake nevertheless appears to be very scant in healthy young subjects, especially women. PURPOSE: We examined the effects of DHEA on adrenal and gonadal hormones, IGF1 and free T3 in healthy young male and female recreationally trained volunteers...
January 10, 2018: Endocrine
https://www.readbyqxmd.com/read/29315457/evaluation-of-sex-hormones-and-sperm-parameters-in-male-epileptic-patients
#8
L Ocek, H Tarhan, F I Uludağ, A Sarıteke, C Köse, A Colak, F Zorlu, Y Zorlu
OBJECTIVES: The aim of this study was to investigate the effect of carbamazepine (CBZ) and sodium valproate (VPA) monotherapy on sexual functions, sex hormones, and semen analysis and quality in male patients with epilepsy. METHODS: A total of 59 male patients with epilepsy, of which 30 were on VPA monotherapy and 29 were on CBZ monotherapy, were included in the study between January 2015 and March 2016. A control group was established with 30 healthy males. Luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), free testosterone (fT), estradiol (E2), sex hormone-binding globulin (SHBG) levels and bioactive testosterone (BAT)/bioactive estradiol (BAE), and BAT/LH ratio were studied in groups...
January 7, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29305800/suspected-ontogeny-of-a-recently-described-hypo-androgenic-pcos-like-phenotype-with-advancing-age
#9
Norbert Gleicher, Vitaly A Kushnir, Sarah K Darmon, Qi Wang, Lin Zhang, David F Albertini, David H Barad
BACKGROUND: A recent report described a new PCOS-like phenotype in lean older infertile women, and was characterized by high age-specific anti-Müllerian hormone (AMH) but hypo- rather than the expected hyper-androgenism. The hypo-androgenism was, furthermore, characterized of, likely, adrenal origin and autoimmune etiology. PATIENTS AND METHODS: We extracted data on 708 consecutive infertility patients, and separated them into three age-strata, <35, 36-42, and >42 years...
January 6, 2018: Endocrine
https://www.readbyqxmd.com/read/29277706/androgen-excess-is-due-to-elevated-11-oxygenated-androgens-in-treated-children-with-congenital-adrenal-hyperplasia
#10
Clemens Kamrath, Lisa Wettstaedt, Claudia Boettcher, Michaela F Hartmann, Stefan A Wudy
Adrenal androgen excess is the hallmark of classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. Recently, 11-oxygenated C19 steroids, a class of highly active adrenal-derived androgens, have been described in patients with CAH. The aim of our study was to elucidate the significance of 11-oxygenated androgens in children with CAH. We retrospectively analysed 190 daily urinary excretion rates of glucocorticoid-, 17α-hydroxyprogesterone (17OHP)-, and androgen metabolites determined by gas chromatography-mass spectrometry of 99 children aged 3...
December 23, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29258367/evaluation-of-prolonged-use-of-statins-on-the-clinical-and-biochemical-abnormalities-and-ovulation-dysfunction-in-single-young-women-with-polycystic-ovary-syndrome
#11
Emaduldin Seyam, Saad Al Gelany, Ahmed Abd Al Ghaney, Marwa Abd Allah Mohamed, Ayman Moheb Youseff, Emad Moussa Ibrahim, Eissa M Khalifa, Enas Hefzy
OBJECTIVE: The aim of the current work was to investigate the effects of prolonged use of Statins on the clinical and biochemical abnormalities and ovulation dysfunction in young single women with polycystic ovary syndrome (PCOS). PATIENTS AND METHODS: It was a randomized, double-blind, placebo-controlled study. Where 200 single young women with PCOS were randomized into either 100 (n = 100) women using Simvastatin 20 mg daily considered as group A (study group), or 100 (n = 100) women using placebo and considered as group B (control group), for six months treatment period...
December 19, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29207177/regulation-of-steroid-hormones-in-the-placenta-and-serum-of-women-with-preeclampsia
#12
Ye Young Shin, Jea Sic Jeong, Mee-Na Park, Jae-Eon Lee, Sung-Min An, Wan-Seob Cho, Seung Chul Kim, Beum-Soo An, Kyu-Sup Lee
Preeclampsia (PE) is a pregnancy‑specific hypertensive syndrome that results in substantial maternal and fetal morbidity and mortality. The exact cause of PE has not been completely elucidate, although abnormal formation of the placenta has been considered. The placenta connects the developing fetus to the uterine wall, producing a large quantity of steroid hormones to maintain pregnancy. Although steroid hormones, particularly progesterone (P4) and estrogen (E2), in the serum of women with PE have been studied, steroidogenesis in the placenta has not well been established...
November 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29206779/concentration-range-of-serum-sex-steroids-in-normal-postmenopausal-women-and-those-with-diagnosis-of-vulvovaginal-atrophy
#13
Yuyong Ke, Alain Bélanger, Jean-Nicolas Simard, Renaud Gonthier, Céline Martel, Mario Vaillancourt, Fernand Labrie
OBJECTIVE: The aim of the study was to determine the range of serum sex-related steroids in normal postmenopausal women and in women of the same age with a diagnosis of vulvovaginal atrophy (VVA). METHODS: Validated mass spectrometry-based assays coupled to gas or liquid chromatography were used over a 10-year period for steroid measurements. Serum samples were obtained in up to 1,512 women aged 55 to 65 years. RESULTS: Serum estrone sulfate (E1S) and androsterone glucuronide (ADT-G), the main metabolites of estrogens and androgens, respectively, were 16...
December 4, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29201667/the-effects-of-adjuvant-therapies-on-embryo-transfer-success
#14
Rachael Shirlow, Martin Healey, Michelle Volovsky, Vivien MacLachlan, Beverley Vollenhoven
Background: Many adjuvant therapies are employed during IVF treatment in an attempt to improve outcomes. The objective of our study was to evaluate the impact of thirteen adjuvants (Intralipid, steroids, melatonin, coenzyme Q10, Filgrastim, testosterone, DHEA, growth hormone, antibiotics, hCG infusion, aspirin, enoxaparin/heparin and dopamine agonists) on the success of embryo transfers. Methods: This is a retrospective cohort study of all embryo transfers between January 2010 and April 2015 from a multi-site IVF clinic...
October 2017: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/29192811/effects-of-vitamin-d-on-ovary-in-dhea-treated-pcos-rat-model-a-light-and-electron-microscopic-study
#15
Latife Seyran Çelik, Yurdun Kuyucu, Ebru Dündar Yenilmez, Abdullah Tuli, Kenan Dağlıoğlu, Ufuk Özgü Mete
AIM: The aim of this study was to investigate the effects of vitamin D treatment on ovary in experimentally designed polycystic ovary syndrome of female rats using light and electron microscopic techniques. METHODS: Twenty-four female pre-pubertal rats were divided into control, DHEA and DHEA+Vit.D groups. In DHEA group, the PCOS rat model was developed by 6mg/kg/day dehydroepiandrosterone administration as subcutaneously injections. In DHEA+Vit.D group, 6 mg/kg/day DHEA and 120ng/100g/week 1,25(OH)2D3 was performed simultaneously...
December 1, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/29192411/increased-serum-neuregulin-4-levels-in-women-with-polycystic-ovary-syndrome-a-case-control-study
#16
Muzaffer Temur, Mehmet Calan, Murat Akşit, Özgür Yılmaz, Tayfur Çift, Burak Akselim, Burcu Dinçgez Çakmak, Emin Üstünyurt
Neuregulin 4 (NRG4) is an adipokine that is synthesized in many tissues and has been shown to be associated with the development of obesity and metabolic disorders in animals and humans. The aim of this study is to investigate the relationship between serum NRG4 levels and various metabolic parameters in women with PCOS. This cross-sectional study included 40 women with PCOS and 40 age- and BMI-matched controls without PCOS. NRG4, fasting blood glucose (FBG), insulin, hs-CRP, LDL-C, HDL-C, SHBG, DHEA-SO4 and total-testosterone levels were measured in all the participants...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/29175736/brain-structural-connectivity-during-adrenarche-associations-between-hormone-levels-and-white-matter-microstructure
#17
Marjolein E A Barendse, Julian G Simmons, Michelle L Byrne, Marc L Seal, George Patton, Lisa Mundy, Stephen J Wood, Craig A Olsson, Nicholas B Allen, Sarah Whittle
Levels of the adrenal hormones dehydroepiandrosterone (DHEA), its sulfate (DHEAS), and testosterone, have all been linked to behavior and mental health during adrenarche, and preclinical studies suggest that these hormones influence brain development. However, little is known about how variation in these hormones is associated with white matter structure during this period of life. The current study aimed to examine associations between DHEA, DHEAS, and testosterone, and white matter microstructure during adrenarche...
November 16, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29164377/systemic-and-local-effects-of-vaginal-dehydroepiandrosterone-dhea-ncctg-n10c1-alliance
#18
Debra L Barton, Lynne T Shuster, Travis Dockter, Pamela J Atherton, Jacqueline Thielen, Stephen N Birrell, Richa Sood, Patricia Griffin, Shelby A Terstriep, Bassam Mattar, Jacqueline M Lafky, Charles L Loprinzi
BACKGROUND: Dehydroepiandrosterone (DHEA) is helpful for treating vaginal symptoms. This secondary analysis evaluated the impact of vaginal DHEA on hormone concentrations, bone turnover, and vaginal cytology in women with a cancer history. METHODS: Postmenopausal women, diagnosed with breast or gynecologic cancer, were eligible if they reported at least moderate vaginal symptoms. Participants could be on tamoxifen or aromatase inhibitors (AIs). Women were randomized to 3...
November 21, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29155118/patterns-of-neuroendocrine-coupling-in-9-year-old-children-effects-of-sex-body-mass-index-and-life-stress
#19
Sarah R Black, Matthew D Lerner, Elizabeth A Shirtcliff, Daniel N Klein
Previous investigations have explored stress and pubertal hormones in parallel; it has been a recent development, however, to explore the relationships between different hormones during puberty, and how this hormonal cross-talk may be influenced by the environment. The current study investigated neuroendocrine coupling, or the extent to which hormones are correlated within the individual, and also investigated early life stressors that may influence coupling. Participants were 405 adrenarcheal children (mean Tanner stage=1...
November 16, 2017: Biological Psychology
https://www.readbyqxmd.com/read/29144993/evaluate-the-effects-of-antiepileptic-drugs-on-reproductive-endocrine-system-in-newly-diagnosed-female-epileptic-patients-receiving-either-valproate-or-lamotrigine-monotherapy-a-prospective-study
#20
Harpreet Singh Sidhu, R Srinivasa, Akshay Sadhotra
OBJECTIVE: To investigate the development of reproductive endocrine changes in Indian women with epilepsy initiating on either Valproate (VPA) or Lamotrigine (LTG) monotherapy. METHODS: Reproductive hormonal profiles, hirsutism, ovarian morphology by ultrasonography and menstrual cycle data in newly diagnosed women with epilepsy taking VPA (n=34) or LTG (n=32) monotherapy were compared. None of the women were receiving hormonal contraception. Patients gave details of seizure type and frequency, medical and drug history...
October 28, 2017: Epilepsy Research
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