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Testosterone AND DHEA

Emma J Gibson, Martin P Bucknall, Blanka Golebiowski, Fiona Stapleton
Sex steroids impact regulation of the ocular surface tissues and thus influence dry eye. Most tissues in the human body synthesise and metabolise active sex steroids at levels required by the tissue. This is likely to also be the case for humans in ocular surface tissues. This study investigated the presence and quantities of selected sex steroids, in addition to sex steroid precursors and metabolites, in human tears. Detection of sex steroids in tears is challenging due to trace level analyte concentrations and low volumes of available tears...
November 15, 2018: Experimental Eye Research
Jerilee M K Azhary, Miyuki Harada, Nozomi Takahashi, Emi Nose, Chisato Kunitomi, Hiroshi Koike, Tetsuya Hirata, Yasushi Hirota, Kaori Koga, Osamu Wada-Hiraike, Tomoyuki Fujii, Yutaka Osuga
Polycystic ovary syndrome (PCOS) is associated with hyperandrogenism and growth arrest of antral follicles. Previously, we found that endoplasmic reticulum (ER) stress is activated in granulosa cells of antral follicles in PCOS, evidenced by activation of unfolded protein response (UPR) genes. Based on this observation, we hypothesized that ER stress is activated by androgens in granulosa cells of antral follicles, and that activated ER stress promotes apoptosis via induction of the UPR transcription factor C/EBP homologous protein (CHOP) and subsequent activation of death receptor (DR) 5...
November 12, 2018: Endocrinology
Jasmien Roosenboom, Karlijne Indencleef, Myoung Keun Lee, Hanne Hoskens, Julie D White, Dongjing Liu, Jacqueline T Hecht, George L Wehby, Lina M Moreno, Carolyn Hodges-Simeon, Eleanor Feingold, Mary L Marazita, Stephen Richmond, Mark D Shriver, Peter Claes, John R Shaffer, Seth M Weinberg
Many factors influence human facial morphology, including genetics, age, nutrition, biomechanical forces, and endocrine factors. Moreover, facial features clearly differ between males and females, and these differences are driven primarily by the influence of sex hormones during growth and development. Specific genetic variants are known to influence circulating sex hormone levels in humans, which we hypothesize, in turn, affect facial features. In this study, we investigated the effects of testosterone-related genetic variants on facial morphology...
2018: Frontiers in Genetics
Toral P Parikh, Brian R Stolze, Yesim Ozarda Ilcol, Jacqueline Jonklaas, Kerry Welsh, Likhona Siphe Masika, Micah J Hill, Alan H DeCherney, Steven John Soldin
OBJECTIVE: Accurate measurement of steroid hormones remains challenging. Mass spectrometry affords a reliable means for quantitating steroid profiles accurately. Our objective was to establish and define 1. the extent of diurnal fluctuations in steroid concentrations that potentially necessitate strict adherence to time of sample acquisition and 2. time dependent steroid reference intervals. DESIGN: Nine steroid markers were examined in couplets in males and females...
October 1, 2018: Endocrine Connections
Timothy S McHale, Peter B Gray, Ka-Chun Chan, David T Zava, Wai-Chi Chee
OBJECTIVES: Little is known about salivary steroid hormone responses to dyadic competition among prepubescent boys. The current study explored pre-match and post-match testosterone, dehydroepiandrosterone (DHEA), androstenedione, and cortisol among 22 ethnically Chinese, Hong Kongese table tennis athletes, aged 8-11 years, during dyadic competition against peers. These data provide novel comparative insight into boys' hormone responses when participating in similar forms of competition to that of adults...
November 2, 2018: American Journal of Human Biology: the Official Journal of the Human Biology Council
Yung Lee, Jerry T Dang, Noah Switzer, James Yu, Chunhong Tian, Daniel W Birch, Shahzeer Karmali
This systematic review and meta-analysis aims to establish the effects of bariatric surgery on male sex hormones, sperm parameters, and sexual function. We searched MEDLINE, EMBASE, Web of Science, and Scopus from database inception through June 2018. Articles were eligible for inclusion if they examined the effect of bariatric surgery on male sex hormones and sperm parameters in patients with obesity. Primary outcomes of interest were sex hormones and sperm quality. Secondary outcome was sexual function (International Index of Erectile Function (IIEF) score)...
October 31, 2018: Obesity Surgery
Ying Zhang, Sheng Cao, Shao-Dun Wen, Zeng-Cai-Dan Re, Yong-Ping Li, Li Tong
OBJECTIVE: To observe the effect of manual acupuncture intervention on the reproductive endocrine and p-Akt protein expression in polycystic ovary syndrome with insulin resistance (PCOS-IR) rats, so as to reveal its mechanism in relieving PCOS-IR. METHODS: Female Wistar rats were randomly divided into control, model, medication (Metformin) and acupuncture groups ( n =8 in each). The PCOS-IR model was established by subcutaneous injection of Dehydroepiandrosterone (DHEA, 6 mg/100 g), once daily for 20 days...
October 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
Soraya Puglisi, Paola Perotti, Mattia Barbot, Paolo Cosio, Carla Scaroni, Antonio Stigliano, Pina Lardo, Valentina Morelli, Elisa Polledri, Iacopo Chiodini, Giuseppe Reimondo, Anna Pia, Massimo Terzolo
OBJECTIVE: Metyrapone has been approved for the treatment of patients with Cushing's syndrome (CS), but only few retrospective clinical studies are available. The aim of our study was the prospective assessment of metyrapone as pre-operative treatment. DESIGN AND METHODS: Before adrenalectomy, 7 patients with ACTH-independent CS due to adrenal adenoma were prospectively treated with metyrapone for 3 months in 3 tertiary academic centers, with endocrine work-up and clinical evaluation at screening and at predefined evaluation time points (Day 14, 31, 48, 65, 82)...
September 1, 2018: Endocrine Connections
Agnieszka Podfigurna, Angelika Stellmach, Anna Szeliga, Adam Czyzyk, Blazej Meczekalski
Premature ovarian insufficiency (POI) is hypogonadism associated with amenorrhea, increased levels of gonadotropins, and hypoestrogenism. Deficiency of estrogens may contribute to higher risk of cardiovascular diseases and death. POI patients present several risk factors for the development of cardiovascular diseases (CVD): endothelial dysfunction, abnormal lipid profile, insulin resistance, and insulin action disturbances. Therefore, patients present a higher risk of developing metabolic syndrome. MATERIALS AND METHODS: Follicle stimulating hormone (FSH), luteinizing hormone (LH), 17β-estradiol (E2), prolactin (PRL), testosterone (T), dehydroepiandrosterone sulfate (DHEA-S), thyroid stimulating hormone (TSH), thyroxine (fT4), fasting serum glucose and insulin concentrations, homeostatic model for insulin resistance (HOMA-IR), and lipid profiles were assessed in 56 women (mean age: 30...
October 21, 2018: Journal of Clinical Medicine
Kok-Min Seow, Ching-Heng Ting, Seng-Wong Huang, Low-Tone Ho, Chi-Chang Juan
OBJECTIVE: Hyperandrogenism is the hallmark of polycystic ovary syndrome (PCOS). The use of dehydroepiandrosterone (DHEA)-treated rats is thought to be a suitable animal model to study PCOS. In the present study, we assessed the severity of reproductive and metabolic abnormalities in DHEA-treated rats. MATERIAL AND METHODS: Immature female Sprague-Dawley rats were divided into control and DHEA-treated groups. Reproductive parameters including estrus cycle and sex hormones were measured after sexual maturity...
October 2018: Taiwanese Journal of Obstetrics & Gynecology
Dan-Ni Zhou, Sai-Jiao Li, Jin-Li Ding, Tai-Lang Yin, Jing Yang, Hong Ye
The polycystic ovary syndrome (PCOS) model was established in rats and correlation between the expression of macrophage migration inhibitory factor (MIF) and cytokinesis with the MAPK signalling pathway in the rat ovary was measured. The PCOS model in rats was established by dehydroepiandrosterone (DHEA). Thirty sexually immature female Sprague-Dawley rats were randomly and equally assigned to three groups: control group, PCOS group, and PCOS with high-fat diet (HFD) group. Serum hormones were assayed by radioimmunoassay (RIA)...
October 2018: Current medical science
Lei Dou, Yahong Zheng, Lu Li, Xiaowei Gui, Yajuan Chen, Meng Yu, Yi Guo
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most prevalent cause of anovulatory infertility and hyperandrogenism. Evidence favors insulin resistance and compensatory hyperinsulinemia as the predominant, perhaps primary, defects in PCOS. The use of insulin-sensitizing drugs has been shown to improve both the reproductive and the metabolic aspects of PCOS. Cinnamon has been found to have insulin sensitizing effect and improve menstrual cyclicity in women with PCOS. The aim of this study was to determine the effect and mechanism of cinnamon on PCOS using a dehydroepiandrosterone (DHEA) induced PCOS mouse model...
October 19, 2018: Reproductive Biology and Endocrinology: RB&E
Amanda Bienenfeld, Sarah Azarchi, Kristen Lo Sicco, Shari Marchbein, Jerry Shapiro, Arielle R Nagler
Androgens are produced throughout the body in steroid-producing organs, such as the adrenal glands and ovaries, as well as in other tissues, like the skin. Several androgens are found normally in women, including dehydroepiandrosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S), testosterone, dihydrotestosterone (DHT), and androstenedione. These androgens are essential in the development of several common cutaneous conditions in women, including acne, hirsutism, and female pattern hair loss (FPHL) - androgen mediated cutaneous disorders (AMCDs)...
October 9, 2018: Journal of the American Academy of Dermatology
Tze Pin Ng, Yanxia Lu, Robin Wai Mun Choo, Crystal Tze Ying Tan, Ma Shwe Z Nyunt, Qi Gao, Esther Wing Hei Mok, Anis Larbi
Sarcopenia, a core feature of the physical frailty syndrome, is characterized by multisystem physiological dysregulation. No study has explored qualitatively the hierarchical network of relationships among different dysregulated pathways involved in the pathogenesis of sarcopenia. We used 40 blood biomarkers belonging to community-dwelling prefrail and frail older persons to derive measures of multiple physiological pathways, and structural equation modeling to generate path network models of the multisystem physiological dysregulations associated with muscle mass and function (MMF)...
October 9, 2018: Aging Cell
Nicholas S Roetker, Richard F MacLehose, Ron C Hoogeveen, Christie M Ballantyne, Saonli Basu, Mary Cushman, Aaron R Folsom
Exogenous hormone treatments in women (oral contraceptives and hormone replacement therapy [HRT]) are established risk factors for venous thromboembolism (VTE), but less is known about associations between plasma levels of endogenous hormones and VTE risk. We examined the association of baseline dehydroepiandrosterone sulphate (DHEAS), testosterone and sex hormone-binding globulin (SHBG) with risk of future VTE in men and post-menopausal women in the Atherosclerosis Risk in Communities Study. Testosterone, DHEAS and SHBG were measured in plasma samples collected in 1996 to 1998...
November 2018: Thrombosis and Haemostasis
Clarissa Daniela Voegel, Pearl La Marca-Ghaemmaghami, Ulrike Ehlert, Markus R Baumgartner, Thomas Kraemer, Tina Maria Binz
The retrospective analysis of endogenous steroid hormones in nails can be used to elucidate endocrine diseases and thus help with their diagnosis and treatment. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) based method was developed for the simultaneous identification and quantification of 12 steroid hormones (aldosterone, cortisone, cortisol, corticosterone, 11-deoxycortisol, androstenedione, 11-deoxycorticosterone, testosterone, dehydroepiandrosterone (DHEA), 17α-hydroxyprogesterone (17-OHP), dihydrotestosterone (DHT) and progesterone) in human fingernails...
October 5, 2018: Steroids
Katiuska Satué, María Marcilla, Pietro Medica, Adriana Ferlazzo, Esterina Fazio
Androgens modulate maternal ovarian activity, embryo implantation and correct placental development. The objective of this study was to establish reference values for testosterone (T), androstenedione (A4 ) and dehydroepiandrosterone (DHEA) concentrations in pregnant mares. A total of 30 healthy Spanish Purebred mares with an age range of 9.33 ± 3.31 years, were studied during the 11 months of gestation. T, A4 and DHEA concentrations were determined using EIA validated specifically for equines. T increased in the 2nd and 3rd month (P < 0...
January 1, 2019: Theriogenology
Sarah E Voelker, Lisa M Lorenz, Jonathan J Litzau
New designer steroids are continually being encountered in dietary supplements that claim to increase muscle mass, but quantitative analysis of such ingredients is challenging due to the availability, quality, or cost of commercial reference materials. Although standard reference material typically becomes available for these emerging compounds, laboratories often face the challenge of finding properly certified materials from accredited suppliers, due to traceability requirements. Several of these designer steroids have been isolated and identified using multiple structural elucidation tools...
September 20, 2018: Drug Testing and Analysis
Julian Koenig, Veronica Thaler, Peter Parzer, Franz Resch, Michael Kaess
OBJECTIVES: Internet gaming disorder (IGD) is associated with altered physiological reactivity to psychosocial stress. Findings from a previous study on alterations of basal hypothalamic-pituitary-adrenal (HPA) axis functioning, indexed by differences in hair hormone levels (i.e., cortisol) in IGD patients compared to matched controls, were limited by a small sample size. METHODS: Following the protocol of the previous study, male patients with IGD (n = 31) and controls (n = 31) matched for age, educational status and smoking were recruited...
September 20, 2018: World Journal of Biological Psychiatry
Mina Amiri, Razieh Bidhendi Yarandi, Fatemeh Nahidi, Maryam Tohidi, Fahimeh Ramezani Tehrani
BACKGROUND AND OBJECTIVE: While has been well demonstrated that clinical characteristics of polycystic ovary syndrome (PCOS) are associated with an impaired quality of life (QoL) in patients, it is unclear that whether the biochemical aspects of PCOS can influence their QoL. We aimed to investigate the relationship between clinical and biochemical characteristics, and various domains of QoL in patients with PCOS. DESIGN: A cross-sectional study. PATIENTS AND MEASUREMENTS: We assessed the association between clinical and biochemical characteristics and QoL domains (psychosocial-emotional, fertility, sexual function, and obesity-menstrual) in a total of 211 women with PCOS using a specific health related quality of life questionnaire for PCOS patients...
September 19, 2018: Clinical Endocrinology
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