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Testosterone AND DHEA

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https://www.readbyqxmd.com/read/29765575/association-of-serum-testosterone-and-dehydroepiandrosterone-sulfate-with-rheumatoid-arthritis-a-case-control-study
#1
Mahin Lashkari, Akram Noori, Sonia Oveisi, Mohammadreza Kheirkhah
Background: It is supposed that hypoandrogenism may be involved in the pathogenesis of rheumatoid arthritis (RA). Testosterone and dehydroepiandrosterone sulfate (DHEAs) levels decrease in body fluids of patients with RA. Objective: The aim of this study was to determine the association of serum testosterone and DHEAs with RA. Methods: This case-control study was conducted on 59 patients with RA and 61 healthy gender- and age-matched controls at Qazvin University of Medical Sciences, Qazvin, Iran, in 2014...
March 2018: Electronic Physician
https://www.readbyqxmd.com/read/29753148/sex-related-differences-in-the-associations-between-maternal-dioxin-like-compounds-and-reproductive-and-steroid-hormones-in-cord-blood-the-hokkaido-study
#2
Chihiro Miyashita, Atsuko Araki, Takahiko Mitsui, Sachiko Itoh, Houman Goudarzi, Seiko Sasaki, Jumboku Kajiwara, Tsuguhide Hori, Kazutoshi Cho, Kimihiko Moriya, Nobuo Shinohara, Katsuya Nonomura, Reiko Kishi
BACKGROUND: Prenatal exposure to dioxin-like compounds (DLCs) irreversibly affects fetal reproductive and steroid hormone synthesis. OBJECTIVE: This study aimed to assess the relationships between maternal DLCs and cord blood reproductive and steroid hormones. METHODS: Participants in this study were pregnant women who enrolled in the Sapporo Cohort of the Hokkaido Study between 2002 and 2005. We quantified 29 DLCs during the 2nd and 3rd trimesters in maternal blood...
May 9, 2018: Environment International
https://www.readbyqxmd.com/read/29743556/no-evidence-for-the-immunocompetence-handicap-hypothesis-in-male-humans
#3
Judyta Nowak, Bogusław Pawłowski, Barbara Borkowska, Daria Augustyniak, Zuzanna Drulis-Kawa
The observations that testosterone might be immunosuppressive, form the basis for the immunocompetence handicap hypothesis (ICHH). According to ICHH only high-quality individuals can maintain high levels of testosterone and afford the physiological cost of hormone-derived immunosuppression. The animal and human studies that attempted to support the ICHH by precisely defined impairment of immunity associated with high testosterone levels are inconclusive. Furthermore, human studies have used only selected immune functions and varying testosterone fractions...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29739821/c-type-natriuretic-peptide-a-link-between-hyperandrogenism-and-anovulation-in-a-mouse-model-of-polycystic-ovary-syndrome
#4
Adelina M Reis, Kinulpe Honorato-Sampaio
The polycystic ovary (PCO) syndrome (PCOS) is the most common cause of anovulatory infertility in women and is associated with several clinical disorders. Despite the great amount of research in the area, mechanisms involved in the genesis of this syndrome remain poorly understood. In a recent issue of Clinical Science (vol. 132, issue 7, 759-776), Wang and colleagues, highlight the important role of overactivated C-type natriuretic peptide (CNP) and natriuretic peptide receptor 2 (CNP/NPR2) system in preventing oocyte maturation and ovulation in PCOS mice model induced by androgen...
May 16, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29725371/analyses-of-risk-factors-for-polycystic-ovary-syndrome-complicated-with-non-alcoholic-fatty-liver-disease
#5
Jianhai Zhang, Jian Hu, Chunxia Zhang, Yanni Jiao, Xiang Kong, Wei Wang
The risk factors related to polycystic ovary syndrome (PCOS) patients complicated with non-alcoholic fatty liver disease (NAFLD) were investigated. A total of 188 PCOS patients treated in Shengli Oilfield Central Hospital (Dongying, China) from February 2014 to February 2015 were retrospectively analyzed as PCOS group, and PCOS group was further divided into NAFLD group and non-NAFLD (N-NAFLD) group according to the liver B ultrasound. In the same time-period, 65 healthy people were selected as normal control group...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29725246/dehydroepiandrosterone-supplementation-combined-with-weight-loading-whole-body-vibration-training-wwbv-affects-exercise-performance-and-muscle-glycogen-storage-in-middle-aged-c57bl-6-mice
#6
Yi-Ming Chen, Hao-Chieh Lee, Mu-Tsung Chen, Chi-Chang Huang, Wen-Chyuan Chen
Background : Adequate nutritional intake and an optimal training program are important elements of any strategy to preserve or increase muscle mass and strength during aging. Purpose : In the current study, we investigate the effects of Dehydroepiandrosterone (DHEA), one of the most abundant circulating steroids in humans and a precursor hormone, supplementation combined with a weight-loading whole-body vibration (WWBV) on exercise performance, physical fatigue-related biochemical responses and testosterone content in middle-aged 9 months old C57BL/6 mice...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29723293/elevated-androstenedione-in-young-adult-but-not-early-adolescent-prenatally-androgenized-female-rats
#7
Ami B Shah, Isaac Nivar, Diana L Speelman
BACKGROUND: Elevated testosterone (T) is routinely reported as a marker of hyperandrogenemia in rodent models for polycystic ovary syndrome (PCOS). In women with PCOS, elevated serum androstenedione (A4) is associated with more severe phenotypes, including a positive correlation with serum T, DHEAS, free androgen index (FAI), LH, and LH/FSH ratio. Furthermore, A4, along with calculated free T and FAI, was identified as one of the best predictors of PCOS in adult women of all ages (18 to > 50 y)...
2018: PloS One
https://www.readbyqxmd.com/read/29713278/dehydroepiandrosterone-antagonizes-pain-stress-induced-suppression-of-testosterone-production-in-male-rats
#8
Qiqi Zhu, Fei Ge, Xiaoheng Li, Hou-Sheng Deng, Miao Xu, Tiao Bu, Jingyang Li, Yiyan Wang, Yuanyuan Shan, Ren-Shan Ge, Ming Yao
Background: Leydig cells secrete the steroid hormone, testosterone, which is essential for male fertility and reproductive health. Stress increases the secretion of glucocorticoid [corticosterone, (CORT) in rats] that decreases circulating testosterone levels in part through a direct action on its receptors in Leydig cells. Intratesticular CORT level is dependent on oxidative inactivation of CORT by 11β-hydroxysteroid dehydrogenase 1 (HSD11B1) in rat Leydig cells. Pain may cause the stress, thus affecting testosterone production in Leydig cells...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29674995/serum-steroid-ratio-profiles-in-prostate-cancer-a-new-diagnostic-tool-toward-a-personalized-medicine-approach
#9
Adriana Albini, Antonino Bruno, Barbara Bassani, Gioacchino D'Ambrosio, Giuseppe Pelosi, Paolo Consonni, Laura Castellani, Matteo Conti, Simone Cristoni, Douglas M Noonan
Background: Serum steroids are crucial molecules altered in prostate cancer (PCa). Mass spectrometry (MS) is currently the elected technology for the analysis of steroids in diverse biological samples. Steroids have complex biological pathways and stoichiometry and it is important to evaluate their quantitative ratio. MS applications to patient hormone profiling could lead to a diagnostic approach. Methods: Here, we employed the Surface Activated Chemical Ionization-Electrospray-NIST (SANIST) developed in our laboratories, to obtain quantitative serum steroid ratio relationship profiles with a machine learning Bayesian model to discriminate patients with PCa...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29671064/the-relationship-between-the-central-serous-chorioretinopathy-choroidal-thickness-and-serum-hormone-levels
#10
Emine Çiloğlu, Fikret Unal, Nese Cetin Dogan
PURPOSE: The purpose of this study were to compare the levels of serum cortisol, aldosterone, testosterone, dehydroepiandrosterone (DHEA), and renin hormone between patients with central serous chorioretinopathy (CSC) and a control group, and to investigate whether there was a difference regarding serum hormone levels in patients with acute/chronic CSC. METHODS: This prospective study included 30 CSC eyes, 30 fellow eyes, and 32 normal eyes of 32 healthy volunteers who were age and sex matched...
April 18, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29600589/associations-of-peritoneal-glucose-load-with-male-sexual-dysfunction-and-depression-in-peritoneal-dialysis-patients
#11
Kamal Hassan, Yotam Elimeleh, Mona Shehadeh, Fadi Hassan, Irina Rubinchik
This cross-sectional study examined possible associations of peritoneal glucose load with male sexual dysfunction and depression in peritoneal dialysis patients. Compared to patients with peritoneal glucose load ≤3 g/kg per day, those with load >3 g/kg per day had higher Beck Depression Inventory scores, (18.9 ± 5.4 vs. 11.4 ± 5.8, P = 0.002) and lower International Index of Erectile Function scores, serum total testosterone and DHEA [(15.4 ± 6.4 vs. 45.1 ± 20.7, P < 0...
March 30, 2018: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29599864/urinary-steroid-profile-in-ironman-triathletes
#12
Marta Marcos-Serrano, Guillermo Olcina, Carmen Crespo, Darrell Brooks, Rafael Timon
The aim of this study was to determine variations in the urinary steroid profile of triathletes following an Ironman event. A total of 10 male participants (age = 36.0 ± 1.27 years; body height = 179.29 ± 10.77 cm; body mass = 74.50 ± 1.04 kg) completed an Ironman Championship. Urine samples were collected before, immediately after, and 24 hours following the race. Gas chromatography-mass spectrometry (GC/MS) was used to detect and quantify catabolic and anabolic hormones: Androsterone, Dehydroepiandrosteone (DHEA), Androstenedione and Testosterone (T), Betaestradiol, Estrone, Progesterone, Cortisol (C), Cortisone, Tetrahydrocortisol (THE) and Tetrahydrocortisone (THF)...
March 2018: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29584875/urine-and-serum-sex-steroid-profile-in-testosterone-treated-transgender-and-hypogonadal-and-healthy-control-men
#13
Sasha Savkovic, Sarina Lim, Veena Jayadev, Ann Conway, Leo Turner, Douglas Curtis, Catrin Goebel, David J Handelsman
Background: The impact of testosterone (T) treatment on anti-doping detection tests in transgender (F2M) men is unknown. We investigated urine and serum sex steroid and LH profiles in T-treated transgender (F2M) to determine whether and, if so, how they differed from hypogonadal and healthy control men. Method: Healthy transgender (n=23) and hypogonadal (n=24) men treated with 1000mg injectable T undecanoate aged 18-50 years provided trough urine and blood samples and an additional earlier post-injection sample (n=21)...
March 22, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29571766/dehydroepiandrosterone-reduces-accumulation-of-lipid-droplets-in-primary-chicken-hepatocytes-by-biotransformation-mediated-via-the-camp-pka-erk1-2-signaling-pathway
#14
Longlong Li, Chongyang Ge, Dian Wang, Lei Yu, Jinlong Zhao, Haitian Ma
Dehydroepiandrosterone (DHEA) is commonly used as a nutritional supplement to control fat deposition, but the mechanism of this action is poorly understood. In this study, we demonstrated that DHEA increased phosphorylation of AMP-activated protein kinase (p-AMPK). Elevated p-AMPK levels resulted in reduced expression of sterol regulatory element binding protein-1c, acetyl CoA carboxylase, fatty acid synthase and enhanced expression of peroxisome proliferators-activated receptor α and carnitine palmitoyl transferase-I, ultimately leading to the reduction of lipid droplet accumulation in primary chicken hepatocytes...
March 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29559788/the-relationship-between-hydration-status-male-sexual-dysfunction-and-depression-in-hemodialysis-patients
#15
Kamal Hassan, Yotam Elimeleh, Mona Shehadeh, Hassan Fadi, Irina Rubinchik
Background: Disturbances in sexual function are common among dialysis patients. Normal erections require a complex balance of physiological, psychological, emotional, hormonal, neurological and vascular factors. This study examined a possible association of overhydration (OH) with male sexual dysfunction and depression in hemodialysis (HD) patients. Patients and methods: This cross-sectional study assessed hydration status by whole-body bioimpedance spectroscopy in patients on maintenance HD for more than 12 months...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29552281/dehydroepiandrosterone-induced-activation-of-mtorc1-and-inhibition-of-autophagy-contribute-to-skeletal-muscle-insulin-resistance-in-a-mouse-model-of-polycystic-ovary-syndrome
#16
Xi Song, Qiyang Shen, Liting Fan, Qiuxiao Yu, Xiao Jia, Yu Sun, Wenpei Bai, Jihong Kang
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age and also an important metabolic disorder associated with insulin resistance (IR). Hyperandrogenism is a key feature of PCOS. However, whether hyperandrogenism can cause IR in PCOS remains largely unknown. The mammalian target of rapamycin complex 1 (mTORC1) and its regulated autophagy are closely associated with IR. In the present study, we investigated the role of mTORC1-autophagy pathway in skeletal muscle IR in a dehydroepiandrosterone (DHEA)-induced PCOS mouse model...
February 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29551255/sex-steroids-sex-hormone-binding-globulin-and-levels-of-n-terminal-pro-brain-natriuretic-peptide-in-postmenopausal-women
#17
Marija Glisic, Lyda Z Rojas, Eralda Asllanaj, Kris G Vargas, Maryam Kavousi, M Arfan Ikram, Bart C J M Fauser, Joop S E Laven, Taulant Muka, Oscar H Franco
BACKGROUND: Amino-terminal pro-B-type natriuretic peptide (NT-proBNP) has a well-documented prognostic value for cardiovascular disease and sex-hormones are suggested to modulate NT-proBNP levels. OBJECTIVE: To examine whether endogenous sex-hormones and sex hormone-binding globulin (SHBG) are associated with NT-proBNP levels in postmenopausal women free of clinical cardiovascular diseases. METHODS: Total estradiol (E2 ), total testosterone (TT), androstenedione (AD), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), sex hormone-binding globulin (SHBG) and NT-proBNP were assessed in 4112 postmenopausal women free of cardiovascular diseases from the prospective population-based Rotterdam Study...
March 6, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29522931/salivary-cortisol-and-cortisone-responses-to-short-term-psychological-stress-challenge-in-late-adolescent-and-young-women-with-different-hyperandrogenic-states
#18
Marco Mezzullo, Flaminia Fanelli, Guido Di Dalmazi, Alessia Fazzini, Daniela Ibarra-Gasparini, Marianna Mastroroberto, Jenny Guidi, Antonio Maria Morselli-Labate, Renato Pasquali, Uberto Pagotto, Alessandra Gambineri
Hyperandrogenic disorders have been associated with psychological distress, reduced quality of life, anxiety and depression. The hypothalamic-pituitary-adrenal (HPA) axis plays a pivotal role in the adaptive response to stressor events. Salivary cortisol (SalF) and cortisone (SalE) testing have been proven to be useful in the evaluation of HPA-axis activity. This study investigated whether SalF and SalE responses to two putative stressor levels differed between the hyperandrogenic states in late adolescent and young women, thus measuring the HPA-axis adaptive response to acute stress events...
May 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29520734/the-effect-of-12-month-dehydroepiandrosterone-supplementation-on-the-menstrual-pattern-ovarian-reserve-markers-and-safety-profile-in-women-with-premature-ovarian-insufficiency
#19
Queenie Ho Yan Wong, Tracy Wing Yee Yeung, Sofie Shuk Fei Yung, Jennifer Ka Yee Ko, Hang Wun Raymond Li, Ernest Hung Yu Ng
PURPOSE: To evaluate the effect of 12-month DHEA supplementation on menstrual pattern and ovarian reserve markers in women with premature ovarian insufficiency (POI) METHODS: This is a prospective observational study. Women with POI were given DHEA supplements (25 mg three times daily) for 12 months. Sonographic assessment for ovarian volume and antral follicle count (AFC) and serum measurement for anti-Mullerian hormone (AMH), follicle stimulating hormone (FSH), estradiol, testosterone, liver function, and hemoglobin level were performed at baseline and monthly for 13 months after the supplementation...
March 9, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29517680/an-ovarian-leydig-cell-tumor-of-ultrasound-negative-in-a-postmenopausal-woman-with-hirsutism-and-hyperandrogenism-a-case-report
#20
Min Chen, Weibin Zhou, Zhe Zhang, Yuting Zou, Chengjiang Li
RATIONALE: The incidence of severe hyperandrogenism associated with masculinity in women is very low. While rare and difficult to diagnose, androgen secreting tumors should be suspected in women with hyperandrogenism and hirsutism, especially in the postmenopausal population. Herein we present one case of ovarian Leydig cell tumor (LCT) with markedly elevated serum testosterone levels and frank hirsutism. PATIENT CONCERNS: A 60-year-old woman, presented with increased hair growth and androgenic alopecia and the hormonal laboratory examination showed that she had elevated serum testosterone level and normal dehydroepiandrosterone sulfate (DHEAS), androstenedione, 17- hydroxyprogesterone, cortisol and thyroid stimulating hormone (TSH)...
March 2018: Medicine (Baltimore)
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