keyword
https://read.qxmd.com/read/38531145/dhea-and-response-to-antidepressant-treatment-a-mendelian-randomization-analysis
#1
JOURNAL ARTICLE
L H Souza-Teodoro, N M Davies, H R Warren, L H S G Andrade, L A Carvalho
Treatment response is hard to predict and detailed mechanisms unknown. Lower levels of the dehydroepiandrosterone sulphate (DHEA(S)) - a precursor to testosterone and estrogen - have been associated to depression and to response to antidepressant treatment. Previous studies however may have been ridden by confounding and reverse causation. The aim of this study is to evaluate whether higher levels of DHEA(S) are causally linked to response to antidepressants using mendelian randomization (MR). We performed a Two-sample MR analysis using data the largest publicly available GWAS of DHEA(S) levels (n = 14,846) using eight common genetic variants associated to DHEA(S) (seven single nucleotide polymorphisms and one variant rs2497306) and the largest GWAS of antidepressant response (n = 5218) using various MR methods (IVW, MR Egger, Weighted mean, weighted mode, MR-PRESSO) and single SNP analysis...
February 28, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38501614/clinical-and-endocrine-alterations-in-women-with-polycystic-ovary-syndrome
#2
JOURNAL ARTICLE
M Kotori, L Ferizi-Shabani, A Koçinaj, V Ferizi, J Kotori
Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder that affects women of reproductive age. Aim - to determine the association between body mass index, hirsutism, acne, and hormonal status with Polycystic ovary syndrome. This cross-sectional study included 55 women with PCOS, between the ages of 18 and 39 who attended the Obstetrics and Gynecology Clinic at the University Clinical Center of Kosovo (UCCK). Body mass index (BMI) was calculated and luteinizing hormone (LH), follicle stimulating hormone (FSH), LH/FSH ratio, testosterone and dehydroepiandrosterone sulfate (DHEA-S) values were determined...
January 2024: Georgian Medical News
https://read.qxmd.com/read/38497394/prevalence-of-endocrine-disorders-in-304-premenopausal-women-referred-with-oligomenorrhoea
#3
JOURNAL ARTICLE
Hamiyet Yilmaz, Mustafa Demirpence, Umit Belet, Ibrahim Ozkiliç, Ayfer Colak, Savas Ceylan, Muammer Sarıkaya, Erdem Yasar
INTRODUCTION: We aimed to evaluate 304 premenopausal women admitted to our clinic for oligomenorrhoea, and to screen for Cushing's syndrome (CS) in this population. MATERIAL AND METHODS: The study included 304 premenopausal women referred to our clinic for oligomenorrhoea. Anthropometric measurements and Ferriman-Gallwey score were evaluated, and thyroid hormone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), total testosterone, prolactin, dehydroepiandrosterone sulphate (DHEA-S), and 17-hydroxyprogesterone (17-OHP) levels were measured in all patients...
2024: Endokrynologia Polska
https://read.qxmd.com/read/38487035/exploring-the-unusual-a-testosterone-secreting-ovarian-tumor
#4
Harpreet Kaur, Neha Singh, Sushma Bharti, Gurwinder Kaur
Ovarian steroid cell tumors are rare, representing less than 0.1% of all ovarian neoplasms. Among the myriad causes of hirsutism, ovarian tumors account for 1% of the reported cases. We present the case of a 49-year-old parous postmenopausal woman who sought medical attention for hirsutism for 2 years. This case illustrates the unusual and interesting connection between rare ovarian pathology and the clinical manifestation of hirsutism in a postmenopausal patient. Her ultrasonography and MRI showed a right adnexal mass of solid-cystic consistency with thin septations...
2024: Autopsy & Case Reports
https://read.qxmd.com/read/38460071/determination-of-cortisol-cut-off-limits-and-steroid-dynamics-in-the-acth-stimulation-test-a-comparative-analysis-using-roche-elecsys-cortisol-ii-immunoassay-and-lc-ms-ms
#5
JOURNAL ARTICLE
Sema Okutan, Nanna Thurmann Jørgensen, Lars Engers Pedersen, Stina Willemoes Borresen, Linda Hilsted, Lennart Friis Hansen, Ulla Feldt-Rasmussen, Marianne Klose
PURPOSE: Measurement of cortisol concentrations is method dependent. The study aimed to establish assay-specific cut-off limits for cortisol after adrenocorticotropic hormone (ACTH) stimulation, comparing Roche Elecsys Cortisol II immunoassay to liquid chromatography-mass spectrometry (LC-MS/MS), and to assess the impact of patient characteristics, estrogen containing oral contraceptives as well as relation to other adrenocortical steroid hormone dynamics. METHODS: One hundred healthy participants underwent a 250 μg ACTH-test, with plasma samples analyzed using ElecsysCortI, ElecsysCortII, and LC-MS/MS...
March 9, 2024: Endocrine
https://read.qxmd.com/read/38401329/sex-and-pubertal-variation-in-reward-related-behavior-and-neural-activation-in-early-adolescents
#6
JOURNAL ARTICLE
M E A Barendse, J R Swartz, S L Taylor, J R Fine, E A Shirtcliff, L Yoon, S J McMillan, L M Tully, A E Guyer
This study aimed to characterize the role of sex and pubertal markers in reward motivation behavior and neural processing in early adolescence. We used baseline and two-year follow-up data from the Adolescent Brain and Cognitive DevelopmentSM study (15844 observations; 52% from boys; age 9-13). Pubertal development was measured with parent-reported Pubertal Development Scale, and DHEA, testosterone, and estradiol levels. Reward motivation behavior and neural processing at anticipation and feedback stages were assessed with the Monetary Incentive Delay task...
February 14, 2024: Developmental Cognitive Neuroscience
https://read.qxmd.com/read/38398368/the-role-of-sodium-glucose-cotransporter-2-inhibitors-in-the-treatment-of-polycystic-ovary-syndrome-a-review
#7
REVIEW
Rachel Porth, Karina Oelerich, Mala S Sivanandy
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-age women impacting their reproductive, mental, and metabolic health. Insulin resistance is a major driver of the pathophysiology of PCOS. There are several challenges with the management of this complex disorder including insufficient treatment options. Over the past 88 years, multiple hormonal and non-hormonal medications have been tried to treat the various components of this syndrome and there is no FDA (Food and Drug Administration)-approved medication specifically for PCOS yet...
February 13, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38397936/placental-mrna-expression-of-neurokinin-b-is-increased-in-pcos-pregnancies-with-female-offspring
#8
JOURNAL ARTICLE
Georgios K Markantes, Evangelia Panagodimou, Vasiliki Koika, Irene Mamali, Apostolos Kaponis, George Adonakis, Neoklis A Georgopoulos
Current research suggests that polycystic ovary syndrome (PCOS) might originate in utero and implicates the placenta in its pathogenesis. Kisspeptin (KISS1) and neurokinin B (NKB) are produced by the placenta in high amounts, and they have been implicated in several pregnancy complications associated with placental dysfunction. However, their placental expression has not been studied in PCOS. We isolated mRNA after delivery from the placentae of 31 PCOS and 37 control women with term, uncomplicated, singleton pregnancies...
February 1, 2024: Biomedicines
https://read.qxmd.com/read/38397159/genetic-aspects-of-problematic-and-risky-internet-use-in-young-men-analysis-of-ankk1-drd2-and-ntrk3-gene-polymorphism
#9
JOURNAL ARTICLE
Aleksandra Rył, Natalia Tomska, Anna Jakubowska, Alicja Ogrodniczak, Joanna Palma, Iwona Rotter
BACKGROUND: Internet addiction disorder (IAD) is characterized by an excess of uncontrolled preoccupations, urges, or behaviors related to computer use and Internet access that culminate in negative outcomes or individual distress. PIU includes excessive online activities (such as video gaming, social media use, streaming, pornography viewing, and shopping). The aim of this study was to analyze the association of gene polymorphisms that may influence the severity of risky behaviors in young men with the frequency of Internet use...
January 27, 2024: Genes
https://read.qxmd.com/read/38369034/the-effect-of-androgens-on-the-risk-of-endometriosis-sub-phenotypes-and-ovarian-neoplasms-a-mendelian-randomization-study
#10
JOURNAL ARTICLE
Marija Gjorgoska, Tea Lanisnik Rizner
Endometriosis is a complex gynecological pathology with a broad spectrum of symptoms, affecting around 10% of reproductive-aged women. Ovarian cancer (OC) is a heterogeneous disease for which we lack effective diagnostic and therapeutic strategies. The etiology and pathogenesis of both diseases remain ambiguous. Androgens in endometriosis could have a distinct role beyond serving as estrogen sources, whereas in the case of serous OC could be important in the formation of precursor lesions which ultimately lead to tumor formation...
February 16, 2024: Journal of Steroid Biochemistry and Molecular Biology
https://read.qxmd.com/read/38368857/hashimoto-s-thyroiditis-negatively-influences-icsi-outcome-in-euthyroid-women-on-t4-substitution-therapy-a-retrospective-study
#11
JOURNAL ARTICLE
Tünde Herman, Péter Török, Antonio Simone Laganà, Vito Chiantera, Renato Venezia, Attila Jakab
OBJECTIVE: To analyze the impact of thyroid autoimmunity (TAI) on reproductive outcome parameters of ICSI cycles as compared to TAI negative ICSI cycles. DESIGN: In this single IVF center retrospective study 86 infertile women with elevated TPOAb or TGAb levels, but euthyroid after thyroxine replacement (study group), were compared to 69 female patients with no thyroid abnormalities (controls). Following ICSI treatment fertilization rate (FR), clinical pregnancy rate (CPR), miscarriage rate (MR) and live birth rate (LBR) were analyzed...
February 17, 2024: Gynecologic and Obstetric Investigation
https://read.qxmd.com/read/38360397/is-it-useful-to-measure-dheas-levels-in-pcos
#12
JOURNAL ARTICLE
Hélène Boucher, Geoffroy Robin, Louise Ribière, Claire Martin, Stéphanie Espiard, Sophie Catteau Jonard
INTRODUCTION: A high prevalence of increased DHEAS (dehydroepiandrosterone sulfate) levels (about a third of cases)has been reported in women with polycystic ovary syndrome (PCOS). This excess of adrenal androgens remains a mystery in this ovarian pathology. It is well known that DHEAS production correlates negatively with age, and study populations of women with PCOS are generally young. To avoid this bias, a study was carried out on a large population of women with PCOS and control women, using normal DHEAS values for each age group, to better assess prevalence and better understand the link between PCOS and DHEAS...
February 13, 2024: Annales D'endocrinologie
https://read.qxmd.com/read/38359577/brain-network-connectivity-during-peer-evaluation-in-adolescent-females-associations-with-age-pubertal-hormones-timing-and-status
#13
JOURNAL ARTICLE
Andrea Pelletier-Baldelli, Margaret A Sheridan, Marc D Rudolph, Tory Eisenlohr-Moul, Sophia Martin, Ellora M Srabani, Matteo Giletta, Paul D Hastings, Matthew K Nock, George M Slavich, Karen D Rudolph, Mitchell J Prinstein, Adam Bryant Miller
Despite copious data linking brain function with changes to social behavior and mental health, little is known about how puberty relates to brain functioning. We investigated the specificity of brain network connectivity associations with pubertal indices and age to inform neurodevelopmental models of adolescence. We examined how brain network connectivity during a peer evaluation fMRI task related to pubertal hormones (dehydroepiandrosterone and testosterone), pubertal timing and status, and age. Participants were 99 adolescents assigned female at birth aged 9-15 (M = 12...
February 10, 2024: Developmental Cognitive Neuroscience
https://read.qxmd.com/read/38356086/simultaneous-quantification-of-endogenous-biomarkers-and-detection-of-testosterone-esters-in-human-serum-using-gas-chromatography-high-resolution-mass-spectrometry
#14
JOURNAL ARTICLE
Dayamín Martínez Brito, Patrizia Leogrande, Daniel Jardines, Xavier de la Torre, Francesco Botrè
RATIONALE: High-resolution mass spectrometry (HRMS) has been demonstrated to be an alternative platform for quantitative analyses, identifying unknown compounds and gathering information for the elucidation of chemical structures. This work describes a method to detect 13 esters of testosterone (T) and 5 biomarkers in 0.1 mL of human serum using gas chromatography (GC) coupled to HRMS. METHODS: Analytes were extracted from serum after deproteinization and liquid-liquid extraction...
March 30, 2024: Rapid Communications in Mass Spectrometry: RCM
https://read.qxmd.com/read/38345304/higher-testosterone-is-associated-with-higher-hdl-cholesterol-and-lower-triglyceride-concentrations-in-older-women-an-observational-study
#15
JOURNAL ARTICLE
S R Davis, Z N Azene, A M Tonkin, R L Woods, J J McNeil, R M Islam
OBJECTIVE: This study aimed to determine whether concentrations of testosterone and its main precursor after menopause, dehydroepiandrosterone (DHEA), are associated with lipoproteins and other lipids in community-dwelling older women. METHODS: The Sex Hormones in Older Women (SHOW) study was an observational study of 6358 Australian women, aged at least 70 years, with no prior major adverse cardiovascular event who had sex hormones measured by liquid chromatography-tandem mass spectrometry...
February 12, 2024: Climacteric: the Journal of the International Menopause Society
https://read.qxmd.com/read/38341016/the-european-biological-variation-study-eubivas-biological-variation-data-for-testosterone-follicle-stimulating-hormone-prolactin-luteinizing-hormone-and-dehydroepiandrosterone-sulfate-in-men
#16
JOURNAL ARTICLE
Outi Itkonen, Niels Jonker, Aasne K Aarsand, Sverre Sandberg, Jorge Diaz-Garzon, Pilar Fernandez-Calle, Abdurrahman Coskun, William A Bartlett, Massimo Locatelli, Anna Carobene
BACKGROUND: Knowledge of biological variation (BV) of hormones is essential for interpretation of laboratory tests and for diagnostics of endocrinological and reproductive diseases. There is a lack of robust BV data for many hormones in men. METHODS: We used serum samples collected weekly over 10 weeks from the European Biological Variation Study (EuBIVAS) to determine BV of testosterone, follicle-stimulating hormone (FSH), prolactin, luteinizing hormone (LH) and dehydroepiandrosterone sulfate (DHEA-S) in 38 men...
February 9, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/38337175/calcium-complexation-by-steroids-involved-in-the-steroidogenesis
#17
JOURNAL ARTICLE
Gastón E Siless, Gabriela M Cabrera
Steroids that take part in the pathways of human steroidogenesis are involved in many biological mechanisms where they interact with calcium. In the present work the binding selectivities and affinities for calcium of progestagens, mineralocorticoids, androstagens and estrogens were studied by ESI-MS. The adduct profile of each steroid was characterized by high resolution and tandem mass spectrometry. The relative stability of the most important adducts was studied by threshold collision induced dissociation, E1/2...
February 9, 2024: Metallomics: Integrated Biometal Science
https://read.qxmd.com/read/38307453/alterations-in-nefa-trafficking-rather-than-hyperandrogenism-contribute-to-metabolic-health-in-obese-women-with-pcos
#18
JOURNAL ARTICLE
Uche Ezeh, Yd Ida Chen, Marita Pall, Richard P Buyalos, Jessica L Chan, Margareta D Pisarska, Ricardo Azziz
OBJECTIVE: To determine whether alterations in non-esterified free fatty acids (NEFA) dynamics or degree of hyperandrogenism (HA) contribute to the difference in insulin sensitivity between metabolically healthy (MHO-PCOS) and metabolically unhealthy (MUO-PCOS) obese PCOS women. DESIGN: Prospective cross-sectional study. SUBJECTS: One hundred-and-twenty-five obese PCOS women. INTERVENTION: Consecutive obese (BMI≥30 kg/m2) oligo-ovulatory PCOS women (n=125) underwent oGTT and a subgroup of 16 participants underwent modified frequently samples intravenous glucose tolerance test (mFSIVGTT), to determine insulin action and NEFA dynamics...
January 31, 2024: Fertility and Sterility
https://read.qxmd.com/read/38293350/effects-of-berberine-on-glucolipid-metabolism-among-dehydroepiandrosterone-induced-rats-of-polycystic-ovary-syndrome-with-insulin-resistance
#19
JOURNAL ARTICLE
Li Li, Yao Xiao, Jiahe Zhou, Hui Mo, Xiaofang Li, Yuancheng Li, Youfeng Wang, Minglin Zhong
Polycystic ovary syndrome (PCOS) is a set of endocrine disorder syndrome characterized by ovulation disorder. Increased insulin resistance (IR) and compensatory hyperinsulinemia play a vital role in the pathogenesis of PCOS. Therefore, insulin sensitizing agents have been studied in the treatment of PCOS. Berberine (BBR) has been proved to alleviate IR in patients with PCOS, but the mechanism remained unclear. This study was aimed to verify the regulatory mechanism of BBR on PCOS-IR rats. Firstly, we established a female rat PCOS-IR model induced by dehydroepiandrosterone (DHEA) and found that estrus cycle was disrupted in the PCOS-IR group, serum fasting insulin (FINS) level and the homeostasis model assessment of insulin resistance (HOMA-IR) index were significantly higher than normal control group...
January 30, 2024: Heliyon
https://read.qxmd.com/read/38254321/comparative-effects-of-the-antioxidant-glutathione-with-metformin-and-diane-35-on-hormonal-metabolic-and-inflammatory-indicators-in-a-dhea-induced-pcos-rat-model
#20
JOURNAL ARTICLE
Aslı Coşar, Pınar Özcan, Fatma Basak Tanoglu, Olgu Enis Tok, Gülçin Özkara, Hikmet Tunç Timur, Çağlar Çetin, Duygu Neccar
OBJECTIVE: Comparison of hormonal, metabolic and inflammatory markers of glutathione with metformin and Diane-35 in a rat model of PCOS induced by dehydroepiandrosterone. METHODS: Twenty-five female rats were randomized into four groups. Group 1 was administered a subcutaneous dose of 0.2 ml saline/day. Group 2 was given 0.2 ml of 1% carboxymethyl cellulose (CMC)/day orally for 28 days. A PCOS model was established with DHEA in rats. Group 3 was given 4...
December 2024: Gynecological Endocrinology
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